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Journal articles on the topic 'PDE2A'

Author: Grafiati

Published: 6 July 2024

Last updated: 31 July 2025

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1

Skryabin, Egor B., Kirstie A. De Jong, Hariharan Subramanian, et al. "CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult Cardiomyocytes Reveals Distinct cAMP Dynamics Regulation by Various PDE2A and PDE3A Isoforms." Cells 12, no. 11 (2023): 1543. http://dx.doi.org/10.3390/cells12111543.

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Cyclic nucleotide phosphodiesterases 2A (PDE2A) and PDE3A play an important role in the regulation of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)-to-cAMP crosstalk. Each of these PDEs has up to three distinct isoforms. However, their specific contributions to cAMP dynamics are difficult to explore because it has been challenging to generate isoform-specific knock-out mice or cells using conventional methods. Here, we studied whether the CRISPR/Cas9 approach for precise genome editing can be used to knock out Pde2a and Pde3a genes and their distinct isoforms

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2

Ivey, F. Douglas, Lili Wang, Didem Demirbas, Christina Allain, and Charles S. Hoffman. "Development of a Fission Yeast-Based High-Throughput Screen to Identify Chemical Regulators of cAMP Phosphodiesterases." Journal of Biomolecular Screening 13, no. 1 (2007): 62–71. http://dx.doi.org/10.1177/1087057107312127.

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Cyclic nucleotide phosphodiesterases (PDEs) comprise a superfamily of enzymes that serve as drug targets in many human diseases. There is a continuing need to identify high-specificity inhibitors that affect individual PDE families or even subtypes within a single family. The authors describe a fission yeast-based high-throughput screen to detect inhibitors of heterologously expressed adenosine 3′,5′-cyclic monophosphate (cAMP) PDEs. The utility of this system is demonstrated by the construction and characterization of strains that express mammalian PDE2A, PDE4A, PDE4B, and PDE8A and respond a

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3

Xu, *Ying. "CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2: A NOVEL TARGET FOR THE TREATMENT OF DEMENTIAS ASSOCIATED WITH ALZHEIMER’ S DISEASE." International Journal of Neuropsychopharmacology 28, Supplement_1 (2025): i290—i291. https://doi.org/10.1093/ijnp/pyae059.514.

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Abstract Background The failure to find effective therapies in the past two decades underscores the challenge and the urgent need for identifying novel targets against Alzheimer's disease (AD). Cyclic nucleotide phosphodiesterase 2 (PDE2) is a "druggable target" which has more advantage than currently developed PDE4 and PDE5 inhibitors due to fewer side effects. Aims & Objectives The overall objective of this proposal is to investigate the role of PDE2 in mediating mitochondrial dysfunction and neurodegeneration, which should provide the rationale for future research toward developing pote

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4

Manns, J. M., K. J. Brennan, S. B. Sheth, and R. W. Colman. "Differential Regulation of Human Platelet Responses by cGMP Inhibited and Stimulated cAMP Phosphodiesterases." Thrombosis and Haemostasis 87, no. 05 (2002): 873–79. http://dx.doi.org/10.1055/s-0037-1613099.

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SummaryPlatelets contain two cAMP phosphodiesterases (PDEs) which regulate intracellular cAMP levels, cGMP-inhibited cAMP PDE (PDE3A) and cGMP-stimulated PDE (PDE2A). Using the PDE3 inhibitor, milrinone and the PDE2 inhibitor, erythro-9-(2-hydroxyl-3-nonyl)adenine (EHNA), we have explored the contribution of each PDE to the regulation of platelet function. Inhibition of PDE2 resulted in higher levels of intracellular cAMP than inhibition of PDE3A suggesting this PDE may be the more important regulator of cAMP in human platelets. However, a concentration-dependent inhibition of agonist-induced

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Carvalho, Thays Maria da Conceição Silva, Silvia Cardarelli, Mauro Giorgi, Andrea Lenzi, Andrea M. Isidori, and Fabio Naro. "Phosphodiesterases Expression during Murine Cardiac Development." International Journal of Molecular Sciences 22, no. 5 (2021): 2593. http://dx.doi.org/10.3390/ijms22052593.

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3′-5′ cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes playing a fundamental role in the control of intracellular levels of cAMP and cGMP. Emerging evidence suggested an important role of phosphodiesterases in heart formation, but little is known about the expression of phosphodiesterases during cardiac development. In the present study, the pattern of expression and enzymatic activity of phosphodiesterases was investigated at different stages of heart formation. C57BL/6 mice were mated and embryos were collected from 14.5 to 18.5 days of development. Data obtained by

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6

Chen, Ling, Suying Cui, Haiyang Yu, et al. "Reduced phosphodiesterase-2 activity in the amygdala results in anxiolytic-like effects on behavior in mice." Journal of Psychopharmacology 33, no. 5 (2019): 568–76. http://dx.doi.org/10.1177/0269881119832753.

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Background: Phosphodiesterase-2 (PDE2) is a cyclic nucleotide phosphodiesterase and is highly expressed in the amygdala, which suggests its important role in anxiety-like behavior. Aims: The present study examined whether reduced PDE2A expression in the central nucleus of the amygdala (CeA) produces anxiolytic-like effects in mice. Methods: PDE2A knockdown in amygdaloid (AR5) cells or the CeA was established using a lentiviral vector-based siRNA system. The anxiety-like behaviors were detected by the elevated plus maze (EPM) and hole-board tests in mice. The related proteins involved in cAMP/c

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Chen, Lin, Jinchi Zhou, Zifeng Zhao, et al. "Low Expression of Phosphodiesterase 2 (PDE2A) Promotes the Progression by Regulating Mitochondrial Morphology and ATP Content and Predicts Poor Prognosis in Hepatocellular Carcinoma." Cells 12, no. 1 (2022): 68. http://dx.doi.org/10.3390/cells12010068.

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Phosphodiesterase 2 (PDE2A) modulates the levels of cAMP/cGMP and was recently found to be involved in mitochondria function regulation, closely related to multiple types of tumor progression. This study aimed to estimate the prognostic significance and biological effects of PDE2A on hepatocellular carcinoma (HCC). We comprehensively analyzed the PDE2A mRNA expression in HCC based on The Cancer Genome Atlas (TCGA) database and investigated the effects of PDE2A on the proliferation and metastatic capacity of HCC cells. PDE2A was downregulated in 25 cancer types, including HCC. Lower PDE2A expre

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8

Barbagallo, Federica, Valentina Rotilio, Maria Rita Assenza, et al. "PDE2A Is Indispensable for Mouse Liver Development and Hematopoiesis." International Journal of Molecular Sciences 21, no. 8 (2020): 2902. http://dx.doi.org/10.3390/ijms21082902.

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Phosphodiesterase 2A (PDE2A) is a cAMP-cGMP hydrolyzing enzyme essential for mouse development and the PDE2A knockout model (PDE2A−/−) is embryonic lethal. Notably, livers of PDE2A−/− embryos at embryonic day 14.5 (E14.5) have extremely reduced size. Morphological, cellular and molecular analyses revealed loss of integrity in the PDE2A−/− liver niche that compromises the hematopoietic function and maturation. Hematopoietic cells isolated from PDE2A−/− livers are instead able to differentiate in in vitro assays, suggesting the absence of blood cell-autonomous defects. Apoptosis was revealed in

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9

Matthiesen, Karina, and Jacob Nielsen. "Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity." Biochemical Journal 423, no. 3 (2009): 401–9. http://dx.doi.org/10.1042/bj20090982.

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To date eleven human PDE (3′,5′-cyclic nucleotide phosphodiesterase) families have been identified. Of these, five families contain non-catalytic tandem GAF (cGMP-specific and -stimulated phosphodiesterases, Anabaenaadenylate cyclases and Escherichia coliFhlA) domains, GAFa and GAFb, in the N-terminal part of the enzyme. For PDE2A, PDE5A and PDE6 the GAF domains have been shown to bind cGMP with high affinity. For PDE2A and PDE5A this ligand binding has been shown to stimulate the catalytic activity of the enzyme. PDE10A and PDE11A are the two most recently described PDEs and it has been sugge

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10

Ritawidya, Ludwig, Briel, Brust, and Scheunemann. "Synthesis and In Vitro Evaluation of 8-Pyridinyl-Substituted Benzo[e]imidazo[2,1-c][1,2,4]triazines as Phosphodiesterase 2A Inhibitors." Molecules 24, no. 15 (2019): 2791. http://dx.doi.org/10.3390/molecules24152791.

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Phosphodiesterase 2A (PDE2A) is highly expressed in distinct areas of the brain, which are known to be related to neuropsychiatric diseases. The development of suitable PDE2A tracers for Positron Emission Tomography (PET) would permit the in vivo imaging of the PDE2A and evaluation of disease-mediated alterations of its expression. A series of novel fluorinated PDE2A inhibitors on the basis of a Benzoimidazotriazine (BIT) scaffold was prepared leading to a prospective inhibitor for further development of a PDE2A PET imaging agent. BIT derivatives (BIT1–9) were obtained by a seven-step synthesi

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Rentsendorj, Otgonchimeg, Mahendra Damarla, Neil R. Aggarwal, et al. "Knockdown of lung phosphodiesterase 2A attenuates alveolar inflammation and protein leak in a two-hit mouse model of acute lung injury." American Journal of Physiology-Lung Cellular and Molecular Physiology 301, no. 2 (2011): L161—L170. http://dx.doi.org/10.1152/ajplung.00073.2011.

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Phosphodiesterase 2A (PDE2A) is stimulated by cGMP to hydrolyze cAMP, a potent endothelial barrier-protective molecule. We previously found that lung PDE2A contributed to a mouse model of ventilator-induced lung injury (VILI). The purpose of the present study was to determine the contribution of PDE2A in a two-hit mouse model of 1-day intratracheal (IT) LPS followed by 4 h of 20 ml/kg tidal volume ventilation. Compared with IT water controls, LPS alone (3.75 μg/g body wt) increased lung PDE2A mRNA and protein expression by 6 h with a persistent increase in protein through day 4 before decreasi

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12

Jiang, Lei, and Shenghu Yan. "Prokaryotic Expression, Purification and Activity Detection of Phosphodiesterase 2A Protein." Journal of Biology and Life Science 11, no. 2 (2020): 1. http://dx.doi.org/10.5296/jbls.v11i2.16650.

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Depression is associated with changes in cyclic guanosine monophosphate (cGMP) levels. Depression can be improved by increasing the cGMP concentration through the cGMP/PKG pathway with PDE2A inhibitors. This study is aimed to improve the expression of a highly active PDE2A protein with an Escherichia coli vector ST6 for the screening of PDE2A inhibitors. PDE2A gene was obtained through polymerase chain reaction. A recombinant plasmid of ST6-PDE2A was built by seamless cloning and then introduced into E. coli BL21 (DE3). The cultivation conditions were optimized to increase target protein expre

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13

Kubacka, Monika, Szczepan Mogilski, Marek Bednarski, et al. "Antiplatelet Effects of Selected Xanthine-Based Adenosine A2A and A2B Receptor Antagonists Determined in Rat Blood." International Journal of Molecular Sciences 24, no. 17 (2023): 13378. http://dx.doi.org/10.3390/ijms241713378.

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The platelet aggregation inhibitory activity of selected xanthine-based adenosine A2A and A2B receptor antagonists was investigated, and attempts were made to explain the observed effects. The selective A2B receptor antagonist PSB-603 and the A2A receptor antagonist TB-42 inhibited platelet aggregation induced by collagen or ADP. In addition to adenosine receptor blockade, the compounds were found to act as moderately potent non-selective inhibitors of phosphodiesterases (PDEs). TB-42 showed the highest inhibitory activity against PDE3A along with moderate activity against PDE2A and PDE5A. The

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Wenzel, Barbara, Stefan R. Fritzsche, Magali Toussaint, et al. "Radiosynthesis and Preclinical Evaluation of an 18F-Labeled Triazolopyridopyrazine-Based Inhibitor for Neuroimaging of the Phosphodiesterase 2A (PDE2A)." Pharmaceuticals 15, no. 10 (2022): 1272. http://dx.doi.org/10.3390/ph15101272.

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The cyclic nucleotide phosphodiesterase 2A is an intracellular enzyme which hydrolyzes the secondary messengers cAMP and cGMP and therefore plays an important role in signaling cascades. A high expression in distinct brain areas as well as in cancer cells makes PDE2A an interesting therapeutic and diagnostic target for neurodegenerative and neuropsychiatric diseases as well as for cancer. Aiming at specific imaging of this enzyme in the brain with positron emission tomography (PET), a new triazolopyridopyrazine-based derivative (11) was identified as a potent PDE2A inhibitor (IC50, PDE2A = 1.9

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Kallenborn-Gerhardt, Wiebke, Ruirui Lu, Aaron Bothe, et al. "Phosphodiesterase 2A Localized in the Spinal Cord Contributes to Inflammatory Pain Processing." Anesthesiology 121, no. 2 (2014): 372–82. http://dx.doi.org/10.1097/aln.0000000000000270.

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Abstract Background: Phosphodiesterase 2A (PDE2A) is an evolutionarily conserved enzyme that catalyzes the degradation of the cyclic nucleotides, cyclic adenosine monophosphate, and/or cyclic guanosine monophosphate. Recent studies reported the expression of PDE2A in the dorsal horn of the spinal cord, pointing to a potential contribution to the processing of pain. However, the functions of PDE2A in spinal pain processing in vivo remained elusive. Methods: Immunohistochemistry, laser microdissection, and quantitative real-time reverse transcription polymerase chain reaction experiments were pe

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Maurin, Thomas, Francesca Melancia, Marielle Jarjat, et al. "Involvement of Phosphodiesterase 2A Activity in the Pathophysiology of Fragile X Syndrome." Cerebral Cortex 29, no. 8 (2018): 3241–52. http://dx.doi.org/10.1093/cercor/bhy192.

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Abstract The fragile X mental retardation protein (FMRP) is an RNA-binding protein involved in translational regulation of mRNAs that play key roles in synaptic morphology and plasticity. The functional absence of FMRP causes the fragile X syndrome (FXS), the most common form of inherited intellectual disability and the most common monogenic cause of autism. No effective treatment is available for FXS. We recently identified the Phosphodiesterase 2A (Pde2a) mRNA as a prominent target of FMRP. PDE2A enzymatic activity is increased in the brain of Fmr1-KO mice, a recognized model of FXS, leading

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Rassi-Cruz, Marcela, Andrea G. Maria, Fabio R. Faucz, et al. "Phosphodiesterase 2A and 3B variants are associated with primary aldosteronism." Endocrine-Related Cancer 28, no. 1 (2021): 1–13. http://dx.doi.org/10.1530/erc-20-0384.

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Abstract Familial primary aldosteronism (PA) is rare and mostly diagnosed in early-onset hypertension (HT). However, ‘sporadic’ bilateral adrenal hyperplasia (BAH) is the most frequent cause of PA and remains without genetic etiology in most cases. Our aim was to investigate new genetic defects associated with BAH and PA. We performed whole-exome sequencing (paired blood and adrenal tissue) in six patients with PA caused by BAH that underwent unilateral adrenalectomy. Additionally, we conducted functional studies in adrenal hyperplastic tissue and transfected cells to confirm the pathogenicity

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Xu, Ying, Jianchun Pan, Ling Chen, et al. "Phosphodiesterase-2 inhibitor reverses corticosterone-induced neurotoxicity and related behavioural changes via cGMP/PKG dependent pathway." International Journal of Neuropsychopharmacology 16, no. 4 (2013): 835–47. http://dx.doi.org/10.1017/s146114571200065x.

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Abstract Phosphodiesterase 2 (PDE2) is an enzyme responsible for hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) to restrict intracellular signalling of these second messenger molecules. This study investigated how PDE2 inhibitor Bay 60-7550 affects the dysregulated glucocorticoid signalling in neuronal cells and regulates depressive behaviours after chronic stress in mice. We found that exposure of hippocampal neurons to corticosterone resulted in time- and concentration-dependent increases in PDE2 expression. These intriguing findings were confir

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Nakashima, Kosuke, and Hideki Matsui. "A Novel Inhibition Modality for Phosphodiesterase 2A." SLAS DISCOVERY: Advancing the Science of Drug Discovery 25, no. 5 (2020): 498–505. http://dx.doi.org/10.1177/2472555220913241.

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Phosphodiesterase type 2A (PDE2A) has received considerable interest as a molecular target for treating central nervous system diseases that affect memory, learning, and cognition. In this paper, the authors present the discovery of small molecules that have a novel modality of PDE2A inhibition. PDE2A possesses GAF-A and GAF-B domains and is a dual-substrate enzyme capable of hydrolyzing both cGMP and cAMP, and activation occurs through cGMP binding to the GAF-B domain. Thus, positive feedback of the catalytic activity to hydrolyze cyclic nucleotides occurs in the presence of appropriate conce

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Li, Dan, Kun Liu, Harvey Davis, et al. "Abnormal Cyclic Nucleotide Signaling at the Outer Mitochondrial Membrane In Sympathetic Neurons During the Early Stages of Hypertension." Hypertension 79, no. 7 (2022): 1374–84. http://dx.doi.org/10.1161/hypertensionaha.121.18882.

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Background: Disruption of cyclic nucleotide signaling in sympathetic postganglionic neurons contributes to impaired intracellular calcium handling (Ca 2+ ) and the development of dysautonomia during the early stages of hypertension, although how this occurs is poorly understood. Emerging evidence supports the uncoupling of signalosomes in distinct cellular compartments involving cyclic nucleotide–sensitive PDEs (phosphodiesterases), which may underpin the autonomic phenotype in stellate neurons. Methods: Using a combination of single-cell RNA sequencing together with Forster resonance energy t

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Ritawidya, Wenzel, Teodoro, et al. "Radiosynthesis and Biological Investigation of a Novel Fluorine-18 Labeled Benzoimidazotriazine- Based Radioligand for the Imaging of Phosphodiesterase 2A with Positron Emission Tomography." Molecules 24, no. 22 (2019): 4149. http://dx.doi.org/10.3390/molecules24224149.

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A specific radioligand for the imaging of cyclic nucleotide phosphodiesterase 2A (PDE2A) via positron emission tomography (PET) would be helpful for research on the physiology and disease-related changes in the expression of this enzyme in the brain. In this report, the radiosynthesis of a novel PDE2A radioligand and the subsequent biological evaluation were described. Our prospective compound 1-(2-chloro-5-methoxy phenyl)-8-(2-fluoropyridin-4-yl)-3- methylbenzo[e]imidazo[5,1-c][1,2,4]triazine, benzoimidazotriazine (BIT1) (IC50 PDE2A = 3.33 nM; 16-fold selectivity over PDE10A) was fluorine-18

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Gong, Wei, Lei Yang, Yuanyuan Wang, et al. "Analysis of Survival-Related lncRNA Landscape Identifies A Role for LINC01537 in Energy Metabolism and Lung Cancer Progression." International Journal of Molecular Sciences 20, no. 15 (2019): 3713. http://dx.doi.org/10.3390/ijms20153713.

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Many long non-coding RNAs (lncRNAs) have emerged as good biomarkers and potential therapeutic targets for various cancers. We aimed to get a detailed understanding of the lncRNA landscape that is associated with lung cancer survival. A comparative analysis between our RNA sequencing (RNA-seq) data and TCGA datasets was conducted to reveal lncRNAs with significant correlations with lung cancer survival and then the association of the most promising lncRNA was validated in a cohort of 243 lung cancer patients. Comparing RNA-seq data with TCGA ones, 84 dysregulated lncRNAs were identified in lung

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Keefer, Christopher E., and George Chang. "The use of matched molecular series networks for cross target structure activity relationship translation and potency prediction." MedChemComm 8, no. 11 (2017): 2067–78. http://dx.doi.org/10.1039/c7md00465f.

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Ding, Hao, Xiao-Xing Xiong, Guan-Lan Fan, et al. "The New Biomarker for Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (CESC) Based on Public Database Mining." BioMed Research International 2020 (April 13, 2020): 1–9. http://dx.doi.org/10.1155/2020/5478574.

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To reconstruct the ceRNA biological network of cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) and to select an appropriate mRNA as a biomarker that could be used for CESC early diagnosis and prognosis evaluation. We downloaded CESC data from the TCGA public database, and statistical analysis was conducted with the R software to find out differential expressed genes encoding for lncRNAs, miRNAs, and mRNAs. The differentially expressed mRNAs (DEmRNAs) screened in the ceRNA network were analyzed for survival to find the mRNAs with significantly linked to the survival prog

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Lu, Jia Yang, and Marion B. Sewer. "p54nrb/NONO Regulates Cyclic AMP-Dependent Glucocorticoid Production by Modulating Phosphodiesterase mRNA Splicing and Degradation." Molecular and Cellular Biology 35, no. 7 (2015): 1223–37. http://dx.doi.org/10.1128/mcb.00993-14.

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Glucocorticoid production in the adrenal cortex is activated in response to an increase in cyclic AMP (cAMP) signaling. The nuclear protein p54nrb/NONO belongs to theDrosophilabehavior/human splicing (DBHS) family and has been implicated in several nuclear processes, including transcription, splicing, and RNA export. We previously identified p54nrb/NONO as a component of a protein complex that regulates the transcription of CYP17A1, a gene required for glucocorticoid production. Based on the multiple mechanisms by which p54nrb/NONO has been shown to control gene expression and the ability of t

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Tanaka, Saori, Rina Tanaka, Saeko Harada, et al. "A PKG inhibitor increases Ca2+-regulated exocytosis in guinea pig antral mucous cells: cAMP accumulation via PDE2A inhibition." American Journal of Physiology-Gastrointestinal and Liver Physiology 304, no. 9 (2013): G773—G780. http://dx.doi.org/10.1152/ajpgi.00281.2012.

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In antral mucous cells, acetylcholine (ACh, 1 μM) activates Ca2+-regulated exocytosis, consisting of an initial peak that declines rapidly (initial transient phase) followed by a second slower decline (late phase) lasting during ACh stimulation. The addition of 8-bromo-cGMP (8-BrcGMP) enhanced the initial phase, which was inhibited by the protein kinase G (PKG) inhibitor guanosine 3′,5′-cyclic monophosphorothoiate, β-phenyl-1, N2-etheno-8-bromo, Rp-isomer, sodium salt (Rp-8-BrPETcGMPS, 100 nM). However, Rp-8-BrPETcGMPS produced a delayed, but transient, increase in the exocytotic frequency dur

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Russwurm, Corina, Georg Zoidl, Doris Koesling, and Michael Russwurm. "Dual Acylation of PDE2A Splice Variant 3." Journal of Biological Chemistry 284, no. 38 (2009): 25782–90. http://dx.doi.org/10.1074/jbc.m109.017194.

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Wang, Jianjie, Susan Bingaman, and Virginia H. Huxley. "Intrinsic sex-specific differences in microvascular endothelial cell phosphodiesterases." American Journal of Physiology-Heart and Circulatory Physiology 298, no. 4 (2010): H1146—H1154. http://dx.doi.org/10.1152/ajpheart.00252.2009.

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The importance of gonadal hormones in the regulation of vascular function has been documented. An alternate and essential contribution of the sex chromosomes to sex differences in vascular function is poorly understood. We reported previously sex differences in microvessel permeability ( Ps) responses to adenosine that were mediated by the cAMP signaling pathway (Wang J, PhD thesis, 2005; Wang J and Huxley V, Proceedings of the VIII World Congress of Microcirculation, 2007 ; Wang J and Huxley VH, Am J Physiol Heart Circ Physiol 291: H3094–H3105, 2006). The two cyclic nucleotides, cAMP and cGMP

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Schmidt, Eric P., Mahendra Damarla, Otgonchimeg Rentsendorj, et al. "Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice." American Journal of Physiology-Lung Cellular and Molecular Physiology 295, no. 6 (2008): L1056—L1065. http://dx.doi.org/10.1152/ajplung.90329.2008.

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High tidal volume (HVT) ventilation causes pulmonary endothelial barrier dysfunction. HVT ventilation also increases lung nitric oxide (NO) and cGMP. NO contributes to HVT lung injury, but the role of cGMP is unknown. In the current study, ventilation of isolated C57BL/6 mouse lungs increased perfusate cGMP as a function of VT. Ventilation with 20 ml/kg VT for 80 min increased the filtration coefficient ( Kf), an index of vascular permeability. The increased cGMP and Kf caused by HVT were attenuated by nitric oxide synthase (NOS) inhibition and in lungs from endothelial NOS knockout mice. Inhi

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Wang, Junnan, Mingyi Wu, Xiaowen Lin, Yun Li та Zhijian Fu. "Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF-κB/p65 Signaling in Chronic Radiculitis Rats". Pain Research and Management 2018 (13 грудня 2018): 1–8. http://dx.doi.org/10.1155/2018/5192814.

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Background. Oxygen/ozone therapy is a minimally invasive technique for the treatment of radiculitis from lumbar disc herniation. This study aimed at investigating whether intrathecal administration of low-concentration oxygen/ozone could attenuate chronic radiculitis and mechanical allodynia after noncompressive lumbar disc herniation and at elucidating the underlying mechanisms. Methods. First, we transplanted autologous nucleus pulposus into dorsal root ganglions to establish chronic radiculitis in rats. Then, filtered oxygen or oxygen/ozone (10, 20, or 30 μg/mL) was intrathecally injected o

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Durand, Julien, Antoine Lampron, Tania L. Mazzuco, Audrey Chapman та Isabelle Bourdeau. "Characterization of Differential Gene Expression in Adrenocortical Tumors Harboring β-Catenin (CTNNB1) Mutations". Journal of Clinical Endocrinology & Metabolism 96, № 7 (2011): E1206—E1211. http://dx.doi.org/10.1210/jc.2010-2143.

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Abstract Background: Mutations of β-catenin gene (CTNNB1) are frequent in adrenocortical adenomas (AA) and adrenocortical carcinomas (ACC). However, the target genes of β-catenin have not yet been identified in adrenocortical tumors. Objective: Our objective was to identify genes deregulated in adrenocortical tumors harboring CTNNB1 genetic alterations and nuclear accumulation of β-catenin. Methods: Microarray analysis identified a dataset of genes that were differently expressed between AA with CTNNB1 mutations and wild-type (WT) tumors. Within this dataset, the expression profiles of five ge

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Juilfs, D. M., W. K. Sonnenburg, S. Seraji, et al. "IDENTIFICATION OF A NEW PDE2A ISOFORM AND EXPRESSION OF PDE2 IN A SUBSET OF OLFACTORY NEURONS & GASTROINTESTINAL CELLS." Biochemical Society Transactions 24, no. 4 (1996): 624S. http://dx.doi.org/10.1042/bst024624s.

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Fryknäs, Mårten, Linda Rickardson, Malin Wickström, et al. "Phenotype-Based Screening of Mechanistically Annotated Compounds in Combination with Gene Expression and Pathway Analysis Identifies Candidate Drug Targets in a Human Squamous Carcinoma Cell Model." Journal of Biomolecular Screening 11, no. 5 (2006): 457–68. http://dx.doi.org/10.1177/1087057106288048.

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The squamous cell carcinoma HeLa cell line and an epithelial cell line hTERT-RPE with a nonmalignant phenotype were interrogated for HeLa cell selectivity in response to 1267 annotated compounds representing 56 pharmacological classes. Selective cytotoxic activity was observed for 14 of these compounds dominated by cyclic adenosine monophosphate (cAMP) selective phosphodiesterase (PDE) inhibitors, which tended to span a representation of the chemical descriptor space of the library. The PDE inhibitors induced delayed cell death with features compatible with classical apoptosis. The PDE inhibit

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Montoya-Durango, Diego, Mary Nancy Walter, Walter Rodriguez, et al. "Dysregulated Cyclic Nucleotide Metabolism in Alcohol-Associated Steatohepatitis: Implications for Novel Targeted Therapies." Biology 12, no. 10 (2023): 1321. http://dx.doi.org/10.3390/biology12101321.

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Background: Cyclic nucleotides are second messengers, which play significant roles in numerous biological processes. Previous work has shown that cAMP and cGMP signaling regulates various pathways in liver cells, including Kupffer cells, hepatocytes, hepatic stellate cells, and cellular components of hepatic sinusoids. Importantly, it has been shown that cAMP levels and enzymes involved in cAMP homeostasis are affected by alcohol. Although the role of cyclic nucleotide signaling is strongly implicated in several pathological pathways in liver diseases, studies describing the changes in genes r

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Petersen, Tonny Studsgaard, Martin Stahlhut, and Claus Yding Andersen. "Phosphodiesterases in the rat ovary: effect of cAMP in primordial follicles." REPRODUCTION 150, no. 1 (2015): 11–20. http://dx.doi.org/10.1530/rep-14-0436.

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Phosphodiesterases (PDEs) are important regulators of the intracellular cAMP concentration, which is a central second messenger that affects a multitude of intracellular functions. In the ovaries, cAMP exerts diverse functions, including regulation of ovulation and it has been suggested that augmented cAMP levels stimulate primordial follicle growth. The present study examined the gene expression, enzyme activity and immunolocalization of the different cAMP hydrolysing PDEs families in the rat ovary. Further, the effect of PDE4 inhibition on primordial follicle activation in cultured neonatal

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Ma, Y. S., Y. H. Xie, D. Ma, J. J. Zhang, and H. J. Liu. "Shear stress-induced MMP1 and PDE2A expressions in coronary atherosclerosis." Bratislava Medical Journal 122, no. 04 (2021): 287–92. http://dx.doi.org/10.4149/bll_2021_048.

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Doummar, Diane, Christel Dentel, Romane Lyautey, et al. "Biallelic PDE2A variants: a new cause of syndromic paroxysmal dyskinesia." European Journal of Human Genetics 28, no. 10 (2020): 1403–13. http://dx.doi.org/10.1038/s41431-020-0641-9.

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Adderley, Shaquria P., Eileen A. Dufaux, Meera Sridharan, et al. "Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans." American Journal of Physiology-Heart and Circulatory Physiology 296, no. 5 (2009): H1617—H1624. http://dx.doi.org/10.1152/ajpheart.01226.2008.

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Activation of the G protein Gs results in increases in cAMP, a necessary step in the pathway for ATP release from rabbit and human erythrocytes. In all cells, the level of cAMP is the product of its synthesis by adenylyl cyclase and its hydrolysis by phosphodiesterases (PDEs). Both iloprost (Ilo), a PGI2 analog, and isoproterenol (Iso), a β-agonist, stimulate receptor-mediated increases in cAMP in rabbit and human erythrocytes. However, the specific PDEs associated with each of these signaling pathways in the erythrocyte have not been fully characterized. Previously, we reported that PDE3B is

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Trabanco, Andrés A., Peter Buijnsters, and Frederik J. R. Rombouts. "Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present)." Expert Opinion on Therapeutic Patents 26, no. 8 (2016): 933–46. http://dx.doi.org/10.1080/13543776.2016.1203902.

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Farmer, Reagan, Steven D. Burbano, Neema S. Patel, Angelo Sarmiento, Abigail J. Smith, and Michy P. Kelly. "Phosphodiesterases PDE2A and PDE10A both change mRNA expression in the human brain with age, but only PDE2A changes in a region-specific manner with psychiatric disease." Cellular Signalling 70 (June 2020): 109592. http://dx.doi.org/10.1016/j.cellsig.2020.109592.

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Fernández-Fernández, Diego, Holger Rosenbrock, and Katja S. Kroker. "Inhibition of PDE2A, but not PDE9A, modulates presynaptic short-term plasticity measured by paired-pulse facilitation in the CA1 region of the hippocampus." Synapse 69, no. 10 (2015): 484–96. http://dx.doi.org/10.1002/syn.21840.

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Zlobin, Alexander S., Natalia A. Volkova, Natalia A. Zinovieva, et al. "Loci Associated with Negative Heterosis for Viability and Meat Productivity in Interspecific Sheep Hybrids." Animals 13, no. 1 (2023): 184. http://dx.doi.org/10.3390/ani13010184.

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Negative heterosis can occur on different economically important traits, but the exact biological mechanisms of this phenomenon are still unknown. The present study focuses on determining the genetic factors associated with negative heterosis in interspecific hybrids between domestic sheep (Ovis aries) and argali (Ovis ammon). One locus (rs417431015) associated with viability and two loci (rs413302370, rs402808951) associated with meat productivity were identified. One gene (ARAP2) was prioritized for viability and three for meat productivity (PDE2A, ARAP1, and PCDH15). The loci associated wit

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Naganawa, M., R. N. Waterhouse, N. Nabulsi, et al. "First-in-Human Assessment of the Novel PDE2A PET Radiotracer 18F-PF-05270430." Journal of Nuclear Medicine 57, no. 9 (2016): 1388–95. http://dx.doi.org/10.2967/jnumed.115.166850.

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Haidar, Zahraa, Nadine Jalkh, Sandra Corbani, et al. "A Homozygous Splicing Mutation in PDE2A in a Family With Atypical Rett Syndrome." Movement Disorders 35, no. 5 (2020): 896–99. http://dx.doi.org/10.1002/mds.28023.

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Wunder, Frank, Mark Jean Gnoth, Andreas Geerts, and Daniel Barufe. "A Novel PDE2A Reporter Cell Line: Characterization of the Cellular Activity of PDE Inhibitors." Molecular Pharmaceutics 6, no. 1 (2008): 326–36. http://dx.doi.org/10.1021/mp800127n.

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Salpietro, Vincenzo, Belen Perez-Dueñas, Kosuke Nakashima, et al. "A homozygous loss-of-function mutation in PDE2A associated to early-onset hereditary chorea." Movement Disorders 33, no. 3 (2018): 482–88. http://dx.doi.org/10.1002/mds.27286.

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Claire, Nicolas, Shittl Julia, Pertuiset Claire, et al. "0310 Assay development and high-throughput screening to identify PDE2A activators to treat heart failure." Archives of Cardiovascular Diseases Supplements 6 (April 2014): 43. http://dx.doi.org/10.1016/s1878-6480(14)71379-5.

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Zhang, Zhao-Xiong, Qiang Han, and Shu-Ye Liu. "Clinical significance of PDE2A in prognosis and immune infiltration in gastrointestinal cancer based on bioinformatics analysis." World Chinese Journal of Digestology 29, no. 18 (2021): 1055–63. http://dx.doi.org/10.11569/wcjd.v29.i18.1055.

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Li, San-Zhong, Kai-Xi Ren, Jing Zhao та ін. "miR-139/PDE2A-Notch1 feedback circuit represses stemness of gliomas by inhibiting Wnt/β-catenin signaling". International Journal of Biological Sciences 17, № 13 (2021): 3508–21. http://dx.doi.org/10.7150/ijbs.62858.

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Sadhu, Krishna, Kelly Hensley, Vince A. Florio, and Sharon L. Wolda. "Differential Expression of the Cyclic GMP-stimulated Phosphodiesterase PDE2A in Human Venous and Capillary Endothelial Cells." Journal of Histochemistry & Cytochemistry 47, no. 7 (1999): 895–905. http://dx.doi.org/10.1177/002215549904700707.

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