Relevant bibliographies by topics / PDIA6

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'PDIA6'

Author: Grafiati
Published: 10 March 2023
Last updated: 31 July 2025

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Journal articles on the topic "PDIA6"

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Passam, Freda H., Angelina Lay, Alexander Dupuy, et al. "Protein Disulphide Isomerase 6 (PDIA6) Attenuates Platelet Endoplasmic Reticulum Stress and Secretion in a Mouse Model." Blood 138, Supplement 1 (2021): 3138. http://dx.doi.org/10.1182/blood-2021-152307.

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Abstract Background: Platelet hyperreactivity involves increased secretion of their granule content which promotes platelet aggregation and thrombosis. Platelet hyperreactivity is observed in conditions such as diabetes mellitus and is associated with decreased cardioprotective effect from antiplatelet agents in this patient group. Diabetes is associated with increased endoplasmic reticulum (ER) stress from hyperglycemia and hyperlipidemia. Protein disulphide isomerase 6 (PDIA6) is an endoplasmic reticulum protein which folds nascent proteins by reduction and oxidation of their disulphide bond
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Cheng, He-Peng, Qian Liu, Yang Li, Xiao-Dong Li, and Chao-Yang Zhu. "The Inhibitory Effect of PDIA6 Downregulation on Bladder Cancer Cell Proliferation and Invasion." Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 25, no. 4 (2017): 587–93. http://dx.doi.org/10.3727/096504016x14761811155298.

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Protein disulfide isomerases A6 (PDIA6) belongs to the PDI family. Recently, PDIA6 was found to have a close association with various cancers. However, there has been little investigation into the biological functions of PDIA6 in bladder cancer (BC). In this study, we explored the expression pattern and functional significance of PDIA6 in BC. We found that PDIA6 was overexpressed in BC tissues and cell lines. The in vitro study showed that PDIA6 downregulation significantly inhibited BC proliferation and invasion. In addition, the in vivo experiment demonstrated that PDIA6 downregulation decre
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Kim, Tae-Wan, Hyang-Hwa Ryu, Song-Yuan Li, et al. "PDIA6 regulation of ADAM17 shedding activity and EGFR-mediated migration and invasion of glioblastoma cells." Journal of Neurosurgery 126, no. 6 (2016): 1829–38. http://dx.doi.org/10.3171/2016.5.jns152831.

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OBJECTIVEIn patients with glioblastoma, local invasion of tumor cells causes recurrence and shortens survival. The goal of this study was to determine whether protein disulfide isomerase (PDI) A6 regulates migration and invasion of glioblastoma cells and the associated factors.METHODSU87MG cells were treated with either PDIA6 or ADAM17 small interfering RNA (siRNA) fragments or with both types of siRNA fragments, and expression was confirmed by reverse transcription–polymerase chain reaction and Western blot. Migration and invasion were assessed using a wound-healing assay, a Matrigel assay, a
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Shen, Chien-Heng, Shui-Yi Tung, Wen-Shih Huang, et al. "Comparative Proteomic Identification of Protein Disulphide Isomerase A6 Associated with Tert-Butylhydroperoxide-Induced Liver Injury in Rat Hepatocytes." Cellular Physiology and Biochemistry 45, no. 5 (2018): 1915–26. http://dx.doi.org/10.1159/000487968.

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Background/Aims: Oxidants are important human toxicants. They have been implicated in the occurrence and development of liver diseases. Increased intracellular tert-butylhydroperoxide (t-BHP) may be critical for oxidant toxicity, and is commonly used for evaluating mechanisms involving oxidative stress, but the method remains controversial. Methods: Primary cultures of hepatocytes as well as human Hep G2 and mouse FL83B liver cells were obtained. Cell viability was measured by annexin V–FITC/propidium iodide and DAPI staining to determine the effects of t-BHP treatment on acute liver injury. A
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Ramos, F. S., L. T. R. Serino, C. M. S. Carvalho, et al. "PDIA3 and PDIA6 gene expression as an aggressiveness marker in primary ductal breast cancer." Genetics and Molecular Research 14, no. 2 (2015): 6960–67. http://dx.doi.org/10.4238/2015.june.26.4.

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Vieujean, S., S. Hu, E. Bequet, et al. "P013 Potential Role of Epithelial Protein Disulphide Isomerases in Crohn’s Disease Fibrosis." Journal of Crohn's and Colitis 15, Supplement_1 (2021): S134—S135. http://dx.doi.org/10.1093/ecco-jcc/jjab076.142.

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Abstract Background Intestinal fibrosis is a common complication of Crohn’s disease (CD) characterized by an accumulation of fibroblasts differentiating into activated myofibroblasts secreting excessive extracellular matrix. In in-vitro experiments, this myofibroblastic differentiation is elicited by a whole series of factors among which transforming growth factor-β1 (TGF-β1) seems to play a key role. The potential role of the intestinal epithelium in this fibrotic process remains poorly defined. Methods We performed a pilot proteomic study comparing the proteome of surface epithelium isolated
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Tufo, G., A. W. E. Jones, Z. Wang, et al. "The protein disulfide isomerases PDIA4 and PDIA6 mediate resistance to cisplatin-induced cell death in lung adenocarcinoma." Cell Death & Differentiation 21, no. 5 (2014): 685–95. http://dx.doi.org/10.1038/cdd.2013.193.

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Zhou, Ping, Lakshmanan K. Iyer, Hani Hassoun, James E. Hoffman, Heather Landau, and Raymond L. Comenzo. "Cyclin D1 Overexpression In Clonal Plasma Cells In Systemic AL Amyloidosis Is Associated with Differential Expression of Protein Quality Control Genes and Bias In Clonal Germline IgVL donor Gene Use." Blood 116, no. 21 (2010): 4043. http://dx.doi.org/10.1182/blood.v116.21.4043.4043.

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Abstract Abstract 4043 Cyclin D1 (CCND1) overexpression in AL plasma cells (PC) is associated with patient characteristics such as production of free immunoglobulin (Ig) light chains (FLC) without an intact M-protein (that is, without partner Ig heavy chains), increased cardiac biomarkers and shorter survival (Amyloid 2010;17(S1):61a; Blood 2008;111:4700; Haematologica 2009;94:380). The molecular ramifications of CCND1 overexpression within AL PC clones have not been described. To study these associations, we used CD138+ AL PC from 69 untreated AL patients at diagnosis for (1) gene expression
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Özenver, Nadire, and Thomas Efferth. "Identification of Prognostic and Predictive Biomarkers and Druggable Targets among 205 Antioxidant Genes in 21 Different Tumor Types via Data-Mining." Pharmaceutics 15, no. 2 (2023): 427. http://dx.doi.org/10.3390/pharmaceutics15020427.

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(1) Background: Oxidative stress is crucial in carcinogenesis and the response of tumors to treatment. Antioxidant genes are important determinants of resistance to chemotherapy and radiotherapy. We hypothesized that genes involved in the oxidative stress response may be valuable as prognostic biomarkers for the survival of cancer patients and as druggable targets. (2) Methods: We mined the KM Plotter and TCGA Timer2.0 Cistrome databases and investigated 205 antioxidant genes in 21 different tumor types within the context of this investigation. (3) Results: Of 4347 calculations with Kaplan–Mei
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Gorasia, Dhana G., Nadine L. Dudek, Helena Safavi-Hemami, et al. "A prominent role of PDIA6 in processing of misfolded proinsulin." Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1864, no. 6 (2016): 715–23. http://dx.doi.org/10.1016/j.bbapap.2016.03.002.

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Dissertations / Theses on the topic "PDIA6"

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Tufo, Grégory. "Recherche de nouveaux biomarqueurs de la résistance au cisplatine dans le cancer du poumon : rôle anti-apoptotique des PDIA4 et PDIA6." Versailles-St Quentin en Yvelines, 2012. http://www.theses.fr/2012VERS0017.

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Environ 80% des cancers du poumon sont des carcinomes du poumon non à petites cellules (NSCLC). Les NSCLC posent un enjeu médical majeur en raison de leur forte incidence et du taux de mortalité qu’ils induisent. Ils sont généralement traités avec le cisplatine (CDDP), l'un des agents anticancéreux les plus largement utilisés aujourd'hui. Cependant, après plusieurs mois, des cellules cancéreuses résistantes à l'apoptose induite par le CDDP apparaissent et compromettent le succès de la chimiothérapie. Le CDDP est un composé pro-apoptotique qui se lie l'ADN nucléaire pour former des liaisons int
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Eletto, Daniela. "Study of bio-molecar interaction: a) Mapping of the interaction between STAT1 and flavonoids; b) Role of PDIA6-BiP complex in the regulation of the unfolded protein response." Doctoral thesis, Universita degli studi di Salerno, 2012. http://hdl.handle.net/10556/1309.

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2010 - 2011<br>Mapping of the interaction between STAT1 and flavonoids Abstract An experimental approach is described, in the first part of this Ph.D. work, for determining protein-small molecule non-covalent ligand binding sites and protein conformational changes induced by ligand binding. The methodology utilizes a combination of multiple technical approaches: limited proteolysis, MALDI TOF MS, circular dichroism and Surface Plasmon Resonance (SPR) to determine the binding sites in signal transducer and activator of transcription 1, STAT1 (87kDa)-flavonoid (Epigallocatechin-3-gallate, Myri
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Bastos, Sara. "Structural studies of protein Disulfide Isomerases: PDIA1 and PDILT." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114530.

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AbstractProtein disulfide isomerases (PDIs) family members are essential for proper folding of proteins entering the secretory pathway. Studies of these remarkable enzymes have shown that PDIs catalyze the oxidation, reduction and isomeration of disulfide bonds in the endoplasmic reticulum (ER). PDIs are found and conserved in a wide range of species and are ubiquitously expressed.In all eukaryotes, the ER redox potential must be tightly controlled since a large fraction of proteins within the cell require disulfide-bond formation. How PDIA1 maintains a balance between oxidation and reduction
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Chen, Jiaxuan. "The role of Pdia3 in vitamin D signaling in osteoblasts." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/50147.

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1a,25-Dihydroxyvitamin D3 (1a,25(OH)2D3) is a major functional metabolic form of vitamin D. 1a,25(OH)2D3 has drawn increasing attention due to its functions in addition to maintaining calcium phosphate homeostasis. It directly regulates mineralization by osteoblasts, matrix production and remodeling by chondrocytes, and contraction of cardiomyocytes. 1a,25(OH)2D3 and its analogues have shown beneficial effects in treating multiple sclerosis, diabetes and various types of cancer. In order to maximize the pharmaceutical potential of 1a,25(OH)2D3, a better understanding its cell signaling pathway
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Silva, Thaís Larissa Araujo de Oliveira. "Estudo da rota de externalização da dissulfeto isomerase protéica (PDIA1) em células endoteliais." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-09112015-113347/.

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Dissulfeto isomerase protéica (PDIA1 ou PDI) é uma chaperona e ditiol-dissulfeto oxido-redutase residente do reticulo endoplasmático (RE). PDI é essencial à regulação da proteostase por ter função no enovelamento oxidativo de proteínas e na via de degradação associada ao RE (ERAD). Além disso, PDI interage fisicamente e regula a atividade de NADPH oxidases, e fora da célula é um regulador redox essencial à atividade de proteínas extracelulares. Este pool epi/pericelular da PDI (pecPDI) regula função de proteínas de membrana/secretadas, como integrinas, glicoproteínas gp120 do virus HIV e outra
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Pyburn, Jaeden, and Matthew Keasey. "Development of PDIA3 and VDR Knockout Human Osteosarcoma SaOs-2 Cells Using CRISPR-Cas9." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/59.

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Intro: Hypovitaminosis D (vitamin D deficiency) has been observed in ageing patients with brain calcification and loss of the vitamin D receptor leads to abnormal calcification of the basal ganglia and thalamus. We have found that vitamin D can reverse calcification of human osteosarcoma SaOs-2 cells in vitro, in apparent contrast to its known effects of increasing bone strength in patients with Rickets and Osteomalacia. Vitamin-D functions through binding to two Vitamin-D responsive proteins; the vitamin D receptor (VDR) and Protein Disulfide isomerase A3 (PDIA3). The aim of this project was
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Linden, Liana de Salles van der. "Avaliação da proteína disulfeto isomerase A1 (PDIA1) como marcador para a qualidade seminal em garanhões." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/182414.

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O período de puberdade, em equinos, define-se pela aparição de espermatozóides maduros no ejaculado de animais jovens, bem como a maturação das funções endócrinas. Os espermatozóides precisam passar por um processo de maturação no epidídimo. Para se obter marcadores moleculares que permitam estabelecer a fertilidade de um garanhão, é necessário um melhor conhecimento das proteínas presentes em espermatozóides imaturos e maduros, uma das quais é a PDI (proteína dissulfeto-isomerase). A PDI foi descrita também como importante marcador de fertilidade no plasma seminal e espermatozóides de diversa
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Bougnoux, Anne-Claire. "Identification et caractérisation de biomarqueurs associés à la progression tumorale du mélanome malin cutané : implication de TRAP1 et PDIA4." Thesis, Montpellier 1, 2014. http://www.theses.fr/2014MON1T014.

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Bien que le mélanome malin cutané (MMC) ne représente que 10% des cancers cutanés, il en est la forme la plus agressive et est responsable de 90% des décès dus aux cancers de la peau. Son incidence ne cesse d'augmenter ces dernières années et atteint 10.8 cas pour 100 000 habitants chez les hommes et 11 chez les femmes. La survie médiane des patients atteint de mélanome à un stade avancé est de 6.2 mois et seulement 1 patient sur 4 est encore en vie à 1an. Le diagnostic du mélanome est uniquement histopathologique et seul l'examen de la biopsie permet de le poser définitivement. De la même faç
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Doroudi, Maryam. "Essential roles of Pdia3/PLAA receptor complex and CaMKII IN 1α,25(OH)₂D₃ and Wnt5a calcium-dependent signaling pathways in osteoblasts and chondrocytes". Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/53427.

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The vitamin D metabolite 1,25-dihydroxyvitamin D3 [1α,25(OH)2D3] plays an important role in the regulation of musculoskeletal growth and differentiation. 1α,25(OH)2D3 mediates its effects on cells, including chondrocytes and osteoblasts, through the classical nuclear 1α,25(OH)2D3 receptor. Additionally, recent evidence indicates that several cellular responses to 1α,25(OH)2D3 are mediated via a rapid, calcium-dependent membrane-mediated pathway. These actions of 1α,25(OH)2D3 can be blocked by antibodies to protein-disulfide isomerase family A, member 3 (Pdia3), indicating that it is part of th
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Goncalves, Renata. "Interactions entre la signalisation estrogénique et la vitamine D dans les cellules testiculaires." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMC411/document.

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La 1α,25(OH)2 vitamine D3 (1,25-D3) est synthétisée à partir du cholestérol par l'exposition solaire de la peau. Les effets de cette hormone sont médiées par le récepteur de la vitamine D (VDR) dans le noyau et à la membrane plasmique, et avec le récepteur PDIA3 ils médient des effets génomiques et non-génomique. La vitamine D joue un rôle important dans la reproduction, puisque la réduction de la fertilité a été observée chez les rats déficients en vitamine D. L'estradiol (E2) est synthétisé à partir de la testostérone par l'enzyme aromatase (CYP19). L’E2 a des effets génomiques et non génomi
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Books on the topic "PDIA6"

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Katalog pameran buku-buku Aceh, tanggal 27 Agustus s/d 3 September 1988 di PDIA-Banda Aceh. Panitia Pusat Pekan Kebudayaan Aceh-3, Sub Seksi Pameran Buku-Buku Aceh, 1988.

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Andrews, Matt. How Do Governments Build Capabilities to Do Great Things? Edited by Carol Lancaster and Nicolas van de Walle. Oxford University Press, 2016. http://dx.doi.org/10.1093/oxfordhb/9780199845156.013.34.

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Governments can play great roles, resolving festering problems and opening new pathways for progress. Examples are numerous and raise an important question: How do governments build the capabilities required to do great things? This chapter identifies ten cases of such governments to answer four dimensions of this question: how do governments to ramp up their capability? Who leads these interventions ?, When do they occur, and why? How changes implemented to ensure they yield sustainable results? The chapter suggests two sets of answers to these concerns, combining rival theories that explain
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Book chapters on the topic "PDIA6"

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Lam, Shing Tat Theodore, and Chinten James Lim. "Cancer Biology of the Endoplasmic Reticulum Lectin Chaperones Calreticulin, Calnexin and PDIA3/ERp57." In Cellular Biology of the Endoplasmic Reticulum. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-67696-4_9.

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Petrevska Nechkoska, Renata, Arber Hajrizaj, Olga Arsic, et al. "PDIA in the Balkans: The Western Balkans Alumni Association (WBAA) as Positive Deviance." In Contributions to Management Science. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-11065-8_9.

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Ogden, Timothy. "RCTs in Development Economics, Their Critics and Their Evolution." In Randomized Control Trials in the Field of Development. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198865360.003.0006.

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The use of Randomized Control Trials (RCTs) in development economics has attracted a consistent drumbeat of criticism, but relatively little response from so-called randomistas (other than a steadily increasing number of practitioners and papers). This chapter systematizes the critiques and discusses the difficulty in responding directly to them. Following this the chapter applies prominent RCT critic Lant Pritchett’s PDIA framework to illustrate how the RCT movement has been responsive to the critiques if not to the critics through a steady evolution of practice. Finally, the chapter assesses
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Clark, David. "A Culture Transformed? Post-PDIA Progress in Palliative and End-of-Life Care." In Transforming the Culture of Dying. Oxford University Press, 2013. http://dx.doi.org/10.1093/acprof:oso/9780199311613.003.0009.

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Nemere, I., N. Garbi, and GJ Hammerling. "Intestinal Cell Phosphate Uptake and the Targeted Knockout of the 1,25D3-MARRS Receptor/PDIA3/Erp57." In The Endocrine Society's 92nd Annual Meeting, June 19–22, 2010 - San Diego. Endocrine Society, 2010. http://dx.doi.org/10.1210/endo-meetings.2010.part1.p4.p1-154.

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Conference papers on the topic "PDIA6"

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Chamberlain, N., B. Korwin-Mihavics, E. Nakada, et al. "Lung Epithelial PDIA3 Plays a Critical Role in Influenza infection." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a1216.

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Robinson, Reeder M., Leticia Reyes, Ravyn Duncan, and Nathan Dolloff. "Abstract 3863: Specifically targeting PDIA1 with indene inhibitors leads to bortezomib-potentiation in multiple myeloma." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-3863.

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Robinson, Reeder M., Leticia Reyes, Ravyn Duncan, and Nathan Dolloff. "Abstract 3863: Specifically targeting PDIA1 with indene inhibitors leads to bortezomib-potentiation in multiple myeloma." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-3863.

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Kumar, A., E. Elko, S. Bruno, et al. "Ablation or Inhibition of Protein Disulfide Isomerase A3 (PDIA3) in Club Cells Attenuates Osteopontin (SPP1) Production and Lung Fibrosis." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4241.

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Miyoshi, Yuji, Seiki Takagi, Shu amiki, and Ken-ichi Kitayama. "Multi period PM OLM with Dynamic Counter Propagating Effects Compensation for 5 bit All optical Analog to digital Conversion." In Optical Fiber Communication Conference. OSA, 2009. http://dx.doi.org/10.1364/ofc.2009.pdpa6.

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Shi, J. W., F. M. Kuo та M. Z. Chou. "A Linear Cascade Near-Ballistic Uni-Traveling-Carrier Photodiodes with Extremely High Saturation-Current Bandwidth Product (6825mA-GHz, 75mA/91GHz) under a 50Ω Load". У Optical Fiber Communication Conference. OSA, 2010. http://dx.doi.org/10.1364/ofc.2010.pdpa6.

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Yu, Jianjun, Ze Dong, Xin Xiao, et al. "Generation, Transmission and Coherent Detection of 11.2 Tb/s (112×100Gb/s) Single Source Optical OFDM Superchannel." In Optical Fiber Communication Conference. OSA, 2011. http://dx.doi.org/10.1364/ofc.2011.pdpa6.

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Miyoshi, Yuji, Seiki Takagi, Shu Namiki, and Ken-ichi Kitayama. "Multi-period PM-NOLM with Dynamic Counter-Propagating Effects Compensation for 5-bit All-optical Analog-to-digital Conversion." In National Fiber Optic Engineers Conference. OSA, 2009. http://dx.doi.org/10.1364/nfoec.2009.pdpa6.

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Shi, J. W., F. M. Kuo та M. Z. Chou. "A Linear Cascade Near-Ballistic Uni-Traveling-Carrier Photodiodes with Extremely High Saturation-Current Bandwidth Product (6825mA-GHz, 75mA/91GHz) under a 50Ω Load". У National Fiber Optic Engineers Conference. OSA, 2010. http://dx.doi.org/10.1364/nfoec.2010.pdpa6.

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Yu, Jianjun, Ze Dong, Xin Xiao, et al. "Generation, Transmission and Coherent Detection of 11.2 Tb/s (112×100Gb/s) Single Source Optical OFDM Superchannel." In National Fiber Optic Engineers Conference. OSA, 2011. http://dx.doi.org/10.1364/nfoec.2011.pdpa6.

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Reports on the topic "PDIA6"

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McNaught, Tim. A Problem-Driven Approach to Education Reform: The Story of Sobral in Brazil. Research on Improving Systems of Education (RISE), 2022. http://dx.doi.org/10.35489/bsg-rise-ri_2022/039.

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For more than two decades, the Brazilian municipality of Sobral has focused intensively on improving the quality of its public education system; the resulting success has been remarkable. In 2005, the Brazilian federal government started calculating a Basic Education Development Index (IDEB in Portuguese), which measures the quality of education in schools across the country. In the inaugural results in 2005, 1,365 municipalities had a better score for primary education than Sobral. By 2017, Sobral made national news by ranking number one in the entire country for both primary and lower second
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Richards, Robin. Can PDIA be Used at a Strategic Level in Multi-Donor Trust Funds and Across Various Phases of Downstream Projects? Institute of Development Studies, 2022. http://dx.doi.org/10.19088/k4d.2022.112.

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This rapid review investigated whether PDIA can be used successfully in Multi-Donor Trust Funds (MDTF) at a strategic level and also across various phases of downstream projects (Verheijen, 2017 and World Bank 2018). The review also identified best practices across the whole programme iteration cycle. The review found that PDIA can be successfully used in MDTF’s and across the various phases of downstream projects. There were few examples illustrating the use the PDIA approach in Multi-Donor Trust Fund interventions. The body of published research on the use of PDIA was relatively small. Howev
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Barjum, Daniel. PDIA for Systems Change: Tackling the Learning Crisis in Indonesia. Research on Improving Systems of Education (RISE), 2022. http://dx.doi.org/10.35489/bsg-rise-ri_2022/046.

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Indonesia is facing a learning crisis. While schooling has increased dramatically in the last 30 years, the quality of education has remained mediocre (Rosser et al., 2022). Teacher capability is an often cited weakness of the system, along with policies and system governance. Approaches focused primarily on adding resources to education have not yielded expected outcomes of increased quality. “It is a tragedy that in the second decade of the twenty-first century, some children in Indonesia are not completing primary school and are turned out into the workforce as functional illiterates.” (Sur
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Samji, Salimah, and Mansi Kapoor. Funda Wande through the Lens of PDIA: Showcasing a Flexible and Iterative Learning Approach to Improving Educational Outcomes. Research on Improving Systems of Education (RISE), 2022. http://dx.doi.org/10.35489/bsg-rise-ri_2022/036.

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Funda Wande has adopted a ‘learning by doing’ strategy that is similar to the Problem Driven Iterative Adaptation (PDIA) approach to solving complex problems. PDIA is a high-impact process of innovation that helps organisations develop the capability to solve complex problems while they are solving such problems. It is a step-by-step framework that helps break down problems into their root causes, identify entry points, search for possible solutions, take action, reflect upon what is learned, adapt, and then act again. Its dynamic process and tight feedback loops enable teams to find and fit s
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