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Relevant bibliographies by topics / PDMS microfluidics

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Academic literature on the topic 'PDMS microfluidics'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 February 2022

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Journal articles on the topic "PDMS microfluidics"

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You, Jae Bem, Byungjin Lee, Yunho Choi, Chang-Soo Lee, Matthias Peter, Sung Gap Im, and Sung Sik Lee. "Nanoadhesive layer to prevent protein absorption in a poly(dimethylsiloxane) microfluidic device." BioTechniques 69, no. 1 (July 2020): 46–51. http://dx.doi.org/10.2144/btn-2020-0025.

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Poly(dimethylsiloxane) (PDMS) is widely used as a microfluidics platform material; however, it absorbs various molecules, perturbing specific chemical concentrations in microfluidic channels. We present a simple solution to prevent adsorption into a PDMS microfluidic device. We used a vapor-phase-deposited nanoadhesive layer to seal PDMS microfluidic channels. Absorption of fluorescent molecules into PDMS was efficiently prevented in the nanolayer-treated PDMS device. Importantly, when cultured in a nanolayer-treated PDMS device, yeast cells exhibited the expected concentration-dependent response to a mating pheromone, including mating-specific morphological and gene expression changes, while yeast cultured in an untreated PDMS device did not properly respond to the pheromone. Our method greatly expands microfluidic applications that require precise control of molecule concentrations.

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Hashemzadeh, Hadi, Abdollah Allahverdi, Mosslim Sedghi, Zahra Vaezi, Tahereh Tohidi Moghadam, Mario Rothbauer, Michael Bernhard Fischer, Peter Ertl, and Hossein Naderi-Manesh. "PDMS Nano-Modified Scaffolds for Improvement of Stem Cells Proliferation and Differentiation in Microfluidic Platform." Nanomaterials 10, no. 4 (April 2, 2020): 668. http://dx.doi.org/10.3390/nano10040668.

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Microfluidics cell-based assays require strong cell-substrate adhesion for cell viability, proliferation, and differentiation. The intrinsic properties of PDMS, a commonly used polymer in microfluidics systems, regarding cell-substrate interactions have limited its application for microfluidics cell-based assays. Various attempts by previous researchers, such as chemical modification, plasma-treatment, and protein-coating of PDMS revealed some improvements. These strategies are often reversible, time-consuming, short-lived with either cell aggregates formation, not cost-effective as well as not user- and eco-friendly too. To address these challenges, cell-surface interaction has been tuned by the modification of PDMS doped with different biocompatible nanomaterials. Gold nanowires (AuNWs), superparamagnetic iron oxide nanoparticles (SPIONs), graphene oxide sheets (GO), and graphene quantum dot (GQD) have already been coupled to PDMS as an alternative biomaterial enabling easy and straightforward integration during microfluidic fabrication. The synthesized nanoparticles were characterized by corresponding methods. Physical cues of the nanostructured substrates such as Young’s modulus, surface roughness, and nanotopology have been carried out using atomic force microscopy (AFM). Initial biocompatibility assessment of the nanocomposites using human amniotic mesenchymal stem cells (hAMSCs) showed comparable cell viabilities among all nanostructured PDMS composites. Finally, osteogenic stem cell differentiation demonstrated an improved differentiation rate inside microfluidic devices. The results revealed that the presence of nanomaterials affected a 5- to 10-fold increase in surface roughness. In addition, the results showed enhancement of cell proliferation from 30% (pristine PDMS) to 85% (nano-modified scaffolds containing AuNWs and SPIONs), calcification from 60% (pristine PDMS) to 95% (PDMS/AuNWs), and cell surface marker expression from 40% in PDMS to 77% in SPION- and AuNWs-PDMS scaffolds at 14 day. Our results suggest that nanostructured composites have a very high potential for stem cell studies and future therapies.

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Chen, Pin-Chuan, Chung-Ying Lee, and Lynh Duong. "Microfabrication of Nonplanar Polymeric Microfluidics." Micromachines 9, no. 10 (September 25, 2018): 491. http://dx.doi.org/10.3390/mi9100491.

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For four decades, microfluidics technology has been used in exciting, state-of-the-art applications. This paper reports on a novel fabrication approach in which micromachining is used to create nonplanar, three-dimensional microfluidic chips for experiments. Several parameters of micromachining were examined to enhance the smoothness and definition of surface contours in the nonplanar poly(methyl methacrylate) (PMMA) mold inserts. A nonplanar PMMA/PMMA chip and a nonplanar polydimethylsiloxane (PDMS)/PMMA chip were fabricated to demonstrate the efficacy of the proposed approach. In the first case, a S-shape microchannel was fabricated on the nonplanar PMMA substrate and sealed with another nonplanar PMMA via solvent bonding. In the second case, a PDMS membrane was casted from two nonplanar PMMA substrates and bonded on hemispherical PMMA substrate via solvent bonding for use as a microlens array (MLAs). These examples demonstrate the effectiveness of micromachining in the fabrication of nonplanar microfluidic chips directly on a polymeric substrate, as well as in the manufacture of nonplanar mold inserts for use in creating PDMS/PMMA microfluidic chips. This technique facilitates the creation of nonplanar microfluidic chips for applications requiring a three-dimensional space for in vitro characterization.

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Chen, Pin Chuan, and Zhi Ping Wang. "A Rapid and Low Cost Manufacturing for Polymeric Microfluidic Devices." Advanced Materials Research 579 (October 2012): 348–56. http://dx.doi.org/10.4028/www.scientific.net/amr.579.348.

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A rapid manufacturing process was demonstrated to fabricate a microfluidic device to amplify specific DNA fragments in less than 8 hours. Microfluidics was derived from microelectromechanical system (MEMS) with lithography technique on the substrates of silicon and glass, which made the microfluidic product have a higher fabrication cost and laborious fabrication steps. This rapid approach only requires three steps for a PDMS microfluidic device: metal mold insert manufacturing, PDMS casting, and glass bonding. Each step did not require complicated equipments or procedures, and make this approach very attractive in rapid prototyping and experimental optimization with microfluidic devices. In this work, a brass mold insert was manufactured by a micromilling machine, followed by the standard PDMS casting and glass bonding to fabricate a microfluidic device. Polymerase chain reaction (PCR) to amplify specific DNA fragments, a typical microfluidic example, was successfully realized on this PDMS microfluidic device. This rapid and low cost (compared to conventional lithography) fabrication approach can provide researchers a lower entry to polymeric lab-on-a-chip either on PDMS or thermoplastic substrate for various applications.

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Lunelli, Lorenzo, Federica Barbaresco, Giorgio Scordo, Cristina Potrich, Lia Vanzetti, Simone Luigi Marasso, Matteo Cocuzza, Candido Fabrizio Pirri, and Cecilia Pederzolli. "PDMS-Based Microdevices for the Capture of MicroRNA Biomarkers." Applied Sciences 10, no. 11 (June 2, 2020): 3867. http://dx.doi.org/10.3390/app10113867.

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The isolation and analysis of circulating biomarkers, the main concern of liquid biopsy, could greatly benefit from microfluidics. Microfluidics has indeed the huge potentiality to bring liquid biopsy into the clinical practice. Here, two polydimethylsiloxane (PDMS)-based microdevices are presented as valid tools for capturing microRNAs biomarkers from clinically-relevant samples. After an extensive study of functionalized polydimethylsiloxane (PDMS) properties in adsorbing/eluting microRNAs, the best conditions were transferred to the microdevices, which were thoroughly characterized. The channels morphology and chemical composition were measured, and parameters for the automation of measures were setup. The best working conditions were then used with microdevices, which were proven to capture microRNAs on all channel surfaces. Finally, microfluidic devices were successfully validated via real-time PCR for the detection of a pool of microRNAs related to non-small cell lung cancer, selected as proof-of-principle. The microfluidic approach described here will allow a step forward towards the realization of an efficient microdevice, possibly automated and integrated into a microfluidic lab-on-a-chip with high analytical potentialities.

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Baczyński, Szymon, Piotr Sobotka, Kasper Marchlewicz, Artur Dybko, and Katarzyna Rutkowska. "Low-cost, widespread and reproducible mold fabrication technique for PDMS-based microfluidic photonic systems." Photonics Letters of Poland 12, no. 1 (March 31, 2020): 22. http://dx.doi.org/10.4302/plp.v12i1.981.

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In this letter the possibility of low-cost fabrication of molds for PDMS-based photonic microstructures is considered. For this purpose, three different commercially available techniques, namely UV-curing of the capillary film, 3D SLA printing and micromilling, have been analyzed. Obtained results have been compared in terms of prototyping time, quality, repeatability, and re-use of the mold for PDMS-based microstructures fabrication. Prospective use for photonic systems, especially optofluidic ones infiltrated with liquid crystalline materials, have been commented. Full Text: PDF References:K. Sangamesh, C.T. Laurencin, M. Deng, Natural and Synthetic Biomedical Polymers (Elsevier, Amsterdam 2004). [DirectLink]A. Mata et. al, "Characterization of Polydimethylsiloxane (PDMS) Properties for Biomedical Micro/Nanosystems", Biomed. Microdev. 7(4), 281 (2005). [CrossRef]I. Rodríguez-Ruiz et al., "Photonic Lab-on-a-Chip: Integration of Optical Spectroscopy in Microfluidic Systems", Anal. Chem. 88(13), 6630 (2016). [CrossRef]SYLGARD™ 184 Silicone Elastomer, Technical Data Sheet [DirectLink]N.E. Stankova et al., "Optical properties of polydimethylsiloxane (PDMS) during nanosecond laser processing", Appl. Surface Science 374, 96 (2016) [CrossRef]J.C. McDonald et al., "Fabrication of microfluidic systems in poly(dimethylsiloxane)", Electrophoresis 21(1), 27 (2000). [CrossRef]T. Fujii, "PDMS-based microfluidic devices for biomedical applications", Microelectronic Eng. 61, 907 (2002). [CrossRef]F. Schneider et al., "Process and material properties of polydimethylsiloxane (PDMS) for Optical MEMS", Sensors Actuat. A: Physical 151(2), 95 (2009). [CrossRef]T.K. Shih et al., "Fabrication of PDMS (polydimethylsiloxane) microlens and diffuser using replica molding", Microelectronic Eng. 83(11-12), 2499 (2006). [CrossRef]K. Rutkowska et al. "Electrical tuning of the LC:PDMS channels", PLP, 9, 48-50 (2017). [CrossRef]D. Kalinowska et al., "Studies on effectiveness of PTT on 3D tumor model under microfluidic conditions using aptamer-modified nanoshells", Biosensors Bioelectr. 126, 214 (2019).[CrossRef]N. Bhattacharjee et al., "The upcoming 3D-printing revolution in microfluidics", Lab on a Chip 16(10), 1720 (2016). [CrossRef]I.R.G. Ogilvie et al., "Reduction of surface roughness for optical quality microfluidic devices in PMMA and COC", J. Micromech. Microeng. 20(6), 065016 (2010). [CrossRef]D. Gomez et al., "Femtosecond laser ablation for microfluidics", Opt. Eng. 44(5), 051105 (2005). [CrossRef]Y. Hwang, R.N. Candler, "Non-planar PDMS microfluidic channels and actuators: a review", Lab on a Chip 17(23), 3948 (2017). [CrossRef]

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Raj M, Kiran, and Suman Chakraborty. "PDMS microfluidics: A mini review." Journal of Applied Polymer Science 137, no. 27 (January 17, 2020): 48958. http://dx.doi.org/10.1002/app.48958.

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Yuan, Yapeng, Yaxiaer Yalikun, Nobutoshi Ota, and Yo Tanaka. "Property Investigation of Replaceable PDMS Membrane as an Actuator in Microfluidic Device." Actuators 7, no. 4 (September 28, 2018): 68. http://dx.doi.org/10.3390/act7040068.

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This paper investigates the basic deflection properties of polydimethylsiloxane (PDMS) membrane as an actuator component in a microfluidic device. Polydimethylsiloxane membrane is a widely used structure in various applications in microfluidics. Most of the applications using PDMS membrane as actuators are pumps, valves, microlenses, and cell stimulators. In these applications, PDMS membranes are deflected to function by applied pressure. However, based on our literature survey, correlations between thickness, applied air pressure, and the deflection properties of replaceable PDMS membrane have not been theoretically and experimentally investigated yet. In this paper, we first conducted a simulation to analyze the relationship between deflection of the replaceable PDMS membrane and applied pressure. Then we verified the deflection of the PDMS membrane in different experimental conditions. Finally, we demonstrated that the PDMS membrane functioned as a valve actuator in a cell-capturing device as one application. We expect this study would work as an important reference for research investigations that use PDMS membrane as an actuator.

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Torino, Stefania, Brunella Corrado, Mario Iodice, and Giuseppe Coppola. "PDMS-Based Microfluidic Devices for Cell Culture." Inventions 3, no. 3 (September 6, 2018): 65. http://dx.doi.org/10.3390/inventions3030065.

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Microfluidic technology has affirmed itself as a powerful tool in medical and biological research by offering the possibility of managing biological samples in tiny channels and chambers. Among the different applications, the use of microfluidics for cell cultures has attracted much interest from scientists worldwide. Traditional cell culture methods need high quantities of samples and reagents that are strongly reduced in miniaturized systems. In addition, the microenvironment is better controlled by scaling down. In this paper, we provide an overview of the aspects related to the design of a novel microfluidic culture chamber, the fabrication approach based on polydimethylsiloxane (PDMS) soft-lithography, and the most critical issues in shrinking the size of the system.

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Davic, Andrew, and Michael Cascio. "Development of a Microfluidic Platform for Trace Lipid Analysis." Metabolites 11, no. 3 (February 24, 2021): 130. http://dx.doi.org/10.3390/metabo11030130.

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The inherent trace quantity of primary fatty acid amides found in biological systems presents challenges for analytical analysis and quantitation, requiring a highly sensitive detection system. The use of microfluidics provides a green sample preparation and analysis technique through small-volume fluidic flow through micron-sized channels embedded in a polydimethylsiloxane (PDMS) device. Microfluidics provides the potential of having a micro total analysis system where chromatographic separation, fluorescent tagging reactions, and detection are accomplished with no added sample handling. This study describes the development and the optimization of a microfluidic-laser induced fluorescence (LIF) analysis and detection system that can be used for the detection of ultra-trace levels of fluorescently tagged primary fatty acid amines. A PDMS microfluidic device was designed and fabricated to incorporate droplet-based flow. Droplet microfluidics have enabled on-chip fluorescent tagging reactions to be performed quickly and efficiently, with no additional sample handling. An optimized LIF optical detection system provided fluorescently tagged primary fatty acid amine detection at sub-fmol levels (436 amol). The use of this LIF detection provides unparalleled sensitivity, with detection limits several orders of magnitude lower than currently employed LC-MS techniques, and might be easily adapted for use as a complementary quantification platform for parallel MS-based omics studies.

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Dissertations / Theses on the topic "PDMS microfluidics"

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Gong, Xiuqing. "PDMS based microfluidic chips and their application in material synthesis /." View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?NSNT%202009%20GONG.

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Lamperti, Emanuele. "PDMS based microfluidics membrane contactors for CO2 removal applications." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/15261/.

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This work proposes a gas-liquid contactor study in microfluidics field, using dense membrane working with a concentration gradient; a microfluidic gas-liquid contactor was developed for CO2 removal and the general idea is to transport CO2 through a polymer dense membrane, followed by its capture by a liquid solvent with chemical absorption. Like recent studies demonstrate, this kind of devices could solve problems related to extracorporeal lung oxygenation (Garofalo, C. Quintavalle, G. Romano, C.M. Croce, 2013) for critical surgical support and critical care medicine, it can work like a real lung because can mimic the architecture of the human vasculature better than the existing technologies. Applications in this fields are related for example to the separation of Xenon from CO2 in anaesthesia. Xe is a very expensive element perfect for anaesthesia, is hemodynamically stable, low soluble in liquid and produces high regional blood flow reducing the risk of hypoxia (Malankowska et al., 2018). The major advantage of using microfluidics devices is that they could be reach a high surface to volume ratio and thanks to miniaturization can be tested reducing the time as well as the production of waste, thus increasing the number of experimental tests can be achieved. In the present thesis in particular one alveolar design channel based of literature results (Malankowska et al., 2018) was realized with soft lithography and tested in different experimental conditions. In particular, for the present geometry the transport of CO2 through the membrane was monitored, calculating the overall mass transfer coefficient and the molar flow of the gas through the membrane in different operating conditions. In additions, the production of other two microfluidics device with different channels configurations was attempted by using a 3-D printing technique that allows the generations of complex structures with high surface to volume ratio.

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Thorslund, Sara. "Microfluidics in Surface Modified PDMS : Towards Miniaturized Diagnostic Tools." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7270.

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JOTHIMUTHU, PREETHA. "Photodefinable Polydimethylsiloxane (PDMS) Thin Films." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1212181335.

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Cartin, Charles. "DESIGN, FABRICATION, AND TESTING OF A PDMS MICROPUMP WITH MOVING MEMBRANES." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2742.

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This paper will discuss the design, fabrication, and testing of a Poly(dimethylsiloxane) (PDMS) microfluidic pump. PDMS is commonly described as a soft polymer with very appealing chemical and physical properties such as optical transparency, low permeability to water, elasticity, low electrical conductivity, and flexible surface chemistry. PDMS microfluidic device fabrication is done easily with the use of soft lithography and rapid prototyping. PDMS microfluidic devices make it easier to integrate components and interface devices with particular users, than using typically harder materials such as glass and silicon. Fabrication and design of single and multilayer PDMS microfluidic devices is much easier and straightforward than traditional methods. A novel design of a PDMS micropump with multiple vibrating membranes has been developed for application in drug delivery and molecule sorting. The PDMS micropump consists of three nozzle/diffuser elements with vibrating membranes, which are used to create pressure difference in the pump chamber. Preliminary analysis of the fluidic characteristics of the micropump was analyzed with ANSYS to investigate the transient responses of fluid velocity, pressure distributions, and flow rate during the operating cycle of the micropump. The design simulation results showed that the movement of the wall membranes combined with rectification behavior of three nozzle/diffuser elements can minimize back flow and improve net flow in one direction. To prove that the theoretical design is valid, the fabrication and testing process of the micropump has been carried out and completed. This paper will discuss in depth the design, fabrication, and testing of the PDMS micropump.

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Redington, Cecile D. "AN ANALYSIS OF ELIMINATING ELECTROOSMOTIC FLOW IN A MICROFLUIDIC PDMS CHIP." DigitalCommons@CalPoly, 2013. https://digitalcommons.calpoly.edu/theses/1079.

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The goal of this project is to eliminate electroosmotic flow (EOF) in a microfluidic chip. EOF is a naturally occurring phenomenon at the fluid-surface interface in microfluidic chips when an electric field is applied across the fluid. When isoelectric focusing (IEF) is carried out to separate proteins based on their surface charge, the analytes must remain in the separation chamber, and not migrate to adjacent features in the microfluidic chip, which happens with EOF. For this project, a microfluidic chip was designed and commissioned to be photolithographically transferred onto a Si wafer. A PDMS component was then casted on the Si wafer and plasma bonded to a glass substrate. This chip was initially designed to carry out continuous IEF, and the focus of the project was shifted to the analysis of eliminating EOF in a microfluidic chamber. Per previous research test methods, methylcellulose will be used to analyze the phenomenon of electroosmotic flow in the chamber. A COMSOL model is used a theoretical basis of comparison when analyzing the flow velocities of the treated versus untreated microfluidic chips. The purpose of this project is to use the research performed in on this chip as a precursor to future analyses of continuous IEF on microfluidic chips in the Cal Poly Microfluidics group.

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Bell, Laurence Livingstone. "Optically interrogated biosensors in microfluidics." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610215.

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NARASIMHAN, JAGANNATHAN. "POLYMER EMBOSSING TOOLS FOR RAPID PROTOTYPING OF PLASTIC MICROFLUIDIC DEVICES." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1061298554.

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Samel, Björn. "Novel Microfluidic Devices Based on a Thermally Responsive PDMS Composite." Doctoral thesis, KTH, Mikrosystemteknik, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4470.

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The field of micro total analysis systems (μTAS) aims at developments toward miniaturized and fully integrated lab-on-a-chip systems for applications, such as drug screening, drug delivery, cellular assays, protein analysis, genomic analysis and handheld point-of-care diagnostics. Such systems offer to dramatically reduce liquid sample and reagent quantities, increase sensitivity as well as speed of analysis and facilitate portable systems via the integration of components such as pumps, valves, mixers, separation units, reactors and detectors. Precise microfluidic control for such systems has long been considered one of the most difficult technical barriers due to integration of on-chip fluidic handling components and complicated off-chip liquid control as well as fluidic interconnections. Actuation principles and materials with the advantages of low cost, easy fabrication, easy integration, high reliability, and compact size are required to promote the development of such systems. Within this thesis, liquid displacement in microfluidic applications, by means of expandable microspheres, is presented as an innovative approach addressing some of the previously mentioned issues. Furthermore, these expandable microspheres are embedded into a PDMS matrix, which composes a novel thermally responsive silicone elastomer composite actuator for liquid handling. Due to the merits of PDMS and expandable microspheres, the composite actuator's main characteristic to expand irreversibly upon generated heat makes it possible to locally alter its surface topography. The composite actuator concept, along with a novel adhesive PDMS bonding technique, is used to design and fabricate liquid handling components such as pumps and valves, which operate at work-ranges from nanoliters to microliters. The integration of several such microfluidic components promotes the development of disposable lab-on-a-chip platforms for precise sample volume control addressing, e.g. active dosing, transportation, merging and mixing of nanoliter liquid volumes. Moreover, microfluidic pumps based on the composite actuator have been incorporated with sharp and hollow microneedles to realize a microneedle-based transdermal patch which exhibits on-board liquid storage and active dispensing functionality. Such a system represents a first step toward painless, minimally invasive and transdermal administration of macromolecular drugs such as insulin or vaccines. The presented on-chip liquid handling concept does not require external actuators for pumping and valving, uses low-cost materials and wafer-level processes only, is highly integrable and potentially enables controlled and cost-effective transdermal microfluidic applications, as well as large-scale integrated fluidic networks for point-of care diagnostics, disposable biochips or lab-on-a-chip applications. This thesis discusses several design concepts for a large variety of microfluidic components, which are promoted by the use of the novel composite actuator. Results on the successful fabrication and evaluation of prototype devices are reported herein along with comprehensive process parameters on a novel full-wafer adhesive bonding technique for the fabrication of PDMS based microfluidic devices.
QC 20100817

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Graham, Brennan P. "Application of Argon Plasma Technology to Hydrophobic and Hydrophilic Microdroplet Generation in PDMS Microfluidic Devices." DigitalCommons@CalPoly, 2017. https://digitalcommons.calpoly.edu/theses/1728.

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Abstract Application of Argon Plasma Technology to Hydrophobic and Hydrophilic Microdroplet Generation in PDMS Microfluidic Devices Brennan Graham Microfluidics has gained popularity over the last decade due to the ability to replace many large, expensive laboratory processes with small handheld chips with a higher throughput due to the small channel dimensions [1]. Droplet microfluidics is the field of fluid manipulation that takes advantage of two immiscible fluids to create droplets from the geometry of the microchannels. This project includes the design of a microfluidic device that applies the results of an argon plasma surface treatment to polydimethylsiloxane (PDMS) to successfully produce both hydrophobic and hydrophilic surfaces to create oil in water (O/W) and water in oil (W/O) microdroplets. If an argon plasma surface treatment renders the surface of PDMS hydrophilic, then O/W microdroplets can be created and integrated into a larger microdroplet emulsion device. The major aims of this project include: (1) validating previously established Cal Poly lab protocols to produce W/O droplets in hydrophobic PDMS microdroplet generators (2) creating hydrophilic PDMS microdroplet generators (3) making oil in water droplets in hydrophilic PDMS microdroplet generators (4) designing a multilayer microfluidic device to transfer W/O droplets to a second hydrophilic PDMS microdroplet generator v W/O droplets were successfully created and transferred to a second hydrophilic PDMS device. The hydrophilic PDMS device also produced O/W droplets in separate testing from the multilayered microfluidic PDMS device. The ultimate purpose of this project is to create a multilayer microdroplet generator that produces water in oil in water (W/O/W) microdroplet emulsions through a stacked device design that can be used in diagnostic microdroplet applications. Thesis Supervisor: Dave Clague Title: Professor of Biomedical Engineering

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Books on the topic "PDMS microfluidics"

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Wei, Li. Dual function magnetic PDMS microsphere-based microfluidic valve and mixer. 2005.

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Book chapters on the topic "PDMS microfluidics"

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Ananthasuresh, G. K., Nandan Maheswari, A. Narayana Reddy, and Deepak Sahu. "Fabrication of Spring Steel and PDMS Grippers for the Micromanipulation of Biological Cells." In Microfluidics and Microfabrication, 333–54. Boston, MA: Springer US, 2009. http://dx.doi.org/10.1007/978-1-4419-1543-6_9.

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Farahi, Farnoosh, and Ian White. "Integration of Capillary Ring Resonator Biosensor with PDMS Microfluidics for Label-Free Biosensing." In IFMBE Proceedings, 305–8. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-14998-6_78.

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Yoo, Jong Chul, C. J. Kang, D. Jeon, and Yong Sang Kim. "Thermopneumatic-Actuated Polydimethylsiloxane (PDMS) Microfluidic System." In Materials Science Forum, 870–73. Stafa: Trans Tech Publications Ltd., 2006. http://dx.doi.org/10.4028/0-87849-995-4.870.

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Jenkins, Gareth. "Rapid Prototyping of PDMS Devices Using SU-8 Lithography." In Microfluidic Diagnostics, 153–68. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-134-9_11.

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Qiu, Wenjun, Chaoqun Wu, and Zhigang Wu. "Surface Modification of PDMS in Microfluidic Devices." In Concise Encyclopedia of High Performance Silicones, 141–50. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118938478.ch10.

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Kim, Ho, Kyung Won Ro, Kwanseop Lim, Nokyoung Park, Mina Kim, and Jong Hoon Hahn. "Adhesive and Dead Volume Free Interfacing between PDMS Microfluidic Channels." In Micro Total Analysis Systems 2002, 401–3. Dordrecht: Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-010-0295-0_134.

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Tan, His Yin, Weng Keong Loke, and Nam-Trung Nguyen. "Integration of PDMS and PMMA for Batch Fabrication of Microfluidic Devices." In IFMBE Proceedings, 1177–80. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-14515-5_298.

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Lewpiriyawong, Nuttawut, and Chun Yang. "Dielectrophoretic Characterization and Continuous Separation of Cells in a PDMS Microfluidic Device with Sidewall Conducting PDMS Composite Electrodes." In Micro and Nano Flow Systems for Bioanalysis, 171–85. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-4376-6_11.

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Dzebic, Medina, Olzhas Kurikov, Oleksander Dobroliubov, and Omar C. A. Nava. "Design and Fabrication of a PDMS Microfluidic Device for Titration of Biological Solutions." In IFMBE Proceedings, 147–52. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4166-2_23.

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Petrucci, G., N. Lovecchio, M. Nardecchia, C. Parrillo, F. Costantini, A. Nascetti, G. de Cesare, and D. Caputo. "Enhancement in PDMS-Based Microfluidic Network for On-Chip Thermal Treatment of Biomolecules." In Lecture Notes in Electrical Engineering, 99–106. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-66802-4_14.

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Conference papers on the topic "PDMS microfluidics"

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Sun, Jianren, Christopher Bock, and Quanfang Chen. "Mechanical Properties of PDMS and Influences by Micromachining Processes." In ASME 2008 International Manufacturing Science and Engineering Conference collocated with the 3rd JSME/ASME International Conference on Materials and Processing. ASMEDC, 2008. http://dx.doi.org/10.1115/msec_icmp2008-72296.

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Microfluidics is both a science and a technology that offers great and perhaps even revolutionary capabilities to impact the society in the future. Polydimethylsiloxane (PDMS) has been widely used in fabricating microfluidic systems but few efforts were made in the past on mechanical properties of PDMS. Very importantly there is no report on influences of microfabrication processes which normally involve chemical reaction processes. A comprehensive investigation was made by authors to study fundamental issues regarding chemical emersion and their effects on mechanical properties of PDMS. Results shown in this work can be used to guide future developments of microfluidics in utilizing PDMS especially those devices involve actuation of PDMS membranes.

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Liu, Miao, Jianren Sun, Ying Sun, and Quanfang Chen. "Mechanical Properties of PDMS Membrane and Influences of Commonly Used Chemicals in Microfabrication." In 2008 Second International Conference on Integration and Commercialization of Micro and Nanosystems. ASMEDC, 2008. http://dx.doi.org/10.1115/micronano2008-70343.

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Microfluidics is both a science and a technology that offers great and perhaps even revolutionary capabilities to impact the society in the future. Polydimethylsiloxane (PDMS) has been widely used in fabricating microfluidic systems but few attentions were paid in the past to mechanical properties of PDMS. Very importantly there is no report on influences of microfabrication processes which normally involve chemical reaction processes. A comprehensive investigation was made by authors to study fundamental issues regarding chemical emersion and their effects on mechanical properties of PDMS. Results shown in this work can be used to guide future developments of microfluidics in utilizing PDMS especially those devices involve actuation of PDMS membranes.

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Nordin, Gregory P., Ryan R. Anderson, Weisheng Hu, Stanley J. Ness, Danny C. Richards, Joseph Oxborrow, Timothy Gustafson, Ben Tsai, Brian Mazzeo, and Adam Woolley. "Microcantilever array sensors with integrated PDMS microfluidics." In 2011 IEEE Sensors. IEEE, 2011. http://dx.doi.org/10.1109/icsens.2011.6127019.

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Helmer, Dorothea, Achim Voigt, Bastian E. Rapp, Frederik Kotz, Tobias M. Nargang, Stefan Wagner, Nico Keller, and Kai Sachsenheimer. "Suspended liquid subtractive lithography: printing three dimensional channels directly into uncured PDMS." In Microfluidics, BioMEMS, and Medical Microsystems XVI, edited by Bonnie L. Gray and Holger Becker. SPIE, 2018. http://dx.doi.org/10.1117/12.2290601.

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Almutairi, Zeyad, Carolyn Ren, and David Johnson. "Effects of Hydrophobic Recovery of Plasma Treated PDMS Microchannels on Surface Tension Driven Flow." In ASME 2010 8th International Conference on Nanochannels, Microchannels, and Minichannels collocated with 3rd Joint US-European Fluids Engineering Summer Meeting. ASMEDC, 2010. http://dx.doi.org/10.1115/fedsm-icnmm2010-31243.

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Surface tension driven flow is used in numerous microfluidic applications. It is considered a passive pumping technique which doesn’t require any external energy, aside from the interfacial surface energy between the fluid and walls. Thus, it is preferred in applications where the goal is fluid and sample transport. In many applications PDMS (Polydimethylsiloxane) is the most adapted material for chip manufacturing in microfluidics. PDMS has several aspects that make it favorable for microfluidic applications. Ease of chip fabrication, cost effectiveness, chemical stability, and good optical properties are features offered by PDMS and desirable for microfluidics. On the other hand, PDMS has some shortcomings. One of importance is that PDMS is naturally hydrophobic. For this reason it is hard to achieve surface tension flow in native PDMS for various fluids used in microfluidics. Thus, native PDMS must be treated to get hydrophilic surface properties. The most used method for altering PDMS properties to a hydrophilic state is by plasma treatment. This treatment has several aspects where it enhances the attachment of PDMS to substrates, it alters the surface from a hydrophobic to a hydrophilic state, and it increases the electrokinetic properties of PDMS. As a result, after plasma treatment surface tension pumping can be achieved in PDMS, unlike native PDMS. However, plasma treatment is not permanent due to the diffusion of non-cured PDMS species to the surface of microchannels, as is well documented in the literature. The change of plasma treated PDMS with time will affect both the electrokinetic and surface tension driven flow. To our knowledge, researchers have quantitatively documented the time effect on plasma treated PDMS microchannels (aging of PDMS) for electrokinetic flow, but not for surface tension driven flow. Therefore, a quantitative examination of the time effect on surface tension driven flow for plasma treated PDMS gives valuable information on both regaining the hydrophobic properties in PDMS and changes in the passive flow conditions. In this work a quantitative study on the hydrophobic recovery for oxygen-plasma treated PDMS and its effects on surface tension flow was examined. The study was performed with a quantitative flow visualization technique (micro particle image velocimetry). It was found that the aging of PDMS will strongly affect surface tension flow of water based solutions in PDMS microchannels. This study gives important information on the effectiveness of surface tension driven flow for oxygen plasma treated PDMS microchannels.

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Nakazawa, Ryota, and Takaaki Ishigure. "Fabrication for polymer microchannels with circular cross-section using photo-curable PDMS (Conference Presentation)." In Microfluidics, BioMEMS, and Medical Microsystems XVIII, edited by Bonnie L. Gray and Holger Becker. SPIE, 2020. http://dx.doi.org/10.1117/12.2545651.

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Sibbitt, John P., and Mei He. "3D Printing of Microfluidics for Point of Care Diagnosis." In ASME 2017 12th International Manufacturing Science and Engineering Conference collocated with the JSME/ASME 2017 6th International Conference on Materials and Processing. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/msec2017-2778.

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Microfluidic lab-on-a-chip (MLOC) technology is a promising approach for point-of-care (POC) diagnosis; low reagent consumption, high sensitivity and quick analysis time are the most prominent benefits. However, microfabrication of MLOCs utilizes specialized techniques and infrastructure, making conventional fabrication time consuming and difficult. While relatively inexpensive production techniques exist for POC diagnoses, such as replication of polymer-based (e.g., PDMS) microfluidic POC devices on lithographic molds, this approach has limitations including: further hydrophilic surface modifications of PDMS, inability to change lithographic mold Z dimensions, and slow prototyping. In contrast, stereo-lithographical (SLA) printing can integrate all of the necessary fabrication resources in one instrument, allowing highly versatile microfluidic devices to be made at low cost. In this paper, we report two microfabrication approaches of microfluidics utilizing (SLA) 3D printing technology: I) Direct SLA printing of channels and structures of a monolithic microfluidic POC device; II) Indirect fabrication, utilizing SLA 3D printed molds for PDMS based microfluidic device replication. Additionally, we discuss previous work providing a proof of concept of applications in POC diagnosis, using direct 3D printing fabrication (approach I). The robustness and simplicity of these protocols allow integrating 3D design and microfabrication with smartphone-based disease diagnosis as a stand-alone system, offering strong adaptability for establishing diagnostic capacity in resource-limited areas and low-income countries.

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Behrens, Stephan, Florian Schmieder, Christoph Polk, and Patrick Schöps. "PDMS free modular plug and play construction kit for the development of micro-physiological systems." In Microfluidics, BioMEMS, and Medical Microsystems XIX, edited by Bonnie L. Gray and Holger Becker. SPIE, 2021. http://dx.doi.org/10.1117/12.2585203.

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Chen, Chien-Fu, Jikun Liu, Chien-Cheng Chang, and Don L. DeVoe. "High Pressure On-Chip Valves for Thermoplastic Microfluidics." In ASME 2009 International Mechanical Engineering Congress and Exposition. ASMEDC, 2009. http://dx.doi.org/10.1115/imece2009-11760.

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A high-pressure microvalve technology based on the integration of discrete elastomeric elements into rigid thermoplastic chips is described. The low-dead-volume valves employ deformable polydimethylsiloxane (PDMS) plugs actuated using a threaded stainless steel needle, allowing exceptionally high pressure resistance to be achieved. The simple fabrication process is made possible through the use of poly(ethylene glycol) (PEG) as a removable blocking material to avoid contamination of PDMS within the flow channel while yielding a smooth contact surface with the PDMS valve surface. Burst pressure tests reveal that the valves can withstand over 24MPa without leakage.

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Abidin, Ummikalsom, Nurul Ayuni Safra Mat Daud, and Valentin Le Brun. "Replication and leakage test of polydimethylsiloxane (PDMS) microfluidics channel." In THE 10TH INTERNATIONAL MEETING OF ADVANCES IN THERMOFLUIDS (IMAT 2018): Smart City: Advances in Thermofluid Technology in Tropical Urban Development. Author(s), 2019. http://dx.doi.org/10.1063/1.5086611.

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