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Dissertations / Theses on the topic 'Pediatric malaria'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Nyberg, Tove, and Madeleine Nilsson. "Experiences in the care of malaria infected children in a pediatric inpatient ward in Tanzania." Thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-192595.

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Background: The number of children under the age of five who dies of malaria per thousand births is sixteen in Tanzania. Even though improvements have been made there are still many challenges in the care of malaria infected children. Aim: The aim of this study was to investigate the experiences that nurses and relatives to malaria infected children have regarding the pediatric malaria care at Kilimanjaro Christian Medical Centre, Tanzania. Method: Semi structured interviews were conducted among three nurses and three relatives to malaria infected children within a pediatric ward at Kilimanjar

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2

Johansson, Emily White. "Beyond “test and treat” : Malaria diagnosis for improved pediatric fever management in sub-Saharan Africa." Doctoral thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-273678.

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This thesis examined malaria test use, adherence and integration into clinical practice for improved pediatric fever management in sub-Saharan African countries and explored Access, Facility Readiness and Clinical Practice bottlenecks to achieve this program goal. Study I examined diagnostic testing rates and its determinants for pediatric fevers across 13 countries in 2009-2012 including Access bottlenecks. Study II evaluated the effect of testing on treatment decisions at the population level in 12 countries in 2010-2012 and explored reasons for varying country results across Access, Facilit

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3

Morris, Carrie Ann. "Population pharmacokinetics of artesunate and dihydroartemisinin in children and pregnant women with malaria." Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/1367.

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Artemisinin derivatives are key to the current global treatment approach for malaria. However, much remains unknown regarding the pharmacokinetics of these agents, particularly in children and pregnant women, two groups highly vulnerable to development of severe malaria infection. In this thesis, nonlinear mixed effects modeling is used to characterize the pharmacokinetics of the artemisinin derivative artesunate and its active metabolite, dihydoartemisinin (DHA), in children and in pregnant women. Chapter 1 of this thesis contains a general review of the clinical pharmacokinetic findings for

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4

Añez, Valdez Arletta. "Resistencia a las drogas antimaláricas en Bolivia." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/587143.

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La cloroquina (CQ) sigue siendo el medicamento de primera línea en todo el mundo para el tratamiento de la malaria por Plasmodium vivax. La dosis recomendada por la OMS es de 25 mg/kg/peso, independientemente de la edad del paciente. Por otro lado, la farmacocinética y la farmacodinámica de los medicamentos; diferente en los niños en relación que los adultos, puede influir en la concentración del fármaco en la sangre y convertirse en factor de riesgo para el fracaso terapéutico y /o resistencia a CQ. Objetivo: Evaluar la eficacia terapéutica de la cloroquina en infecciones por Plasmodium viva

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Carrasco, Colom Jaume. "Influència de la resposta immunitària innata en la malaltia pneumocòccica invasiva greu: polimorfismes genètics en la via de senyalització Toll-IL1R i expressió de la L-selectina en leucòcits." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/456370.

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INTRODUCCIÓ: La malaltia pneumocòccica invasiva (MPI) pot tenir una elevada morbimortalitat, condicionada pel pneumococ i per factors de l’hoste com els receptors Toll-like (TLRs) i la seva via de senyalització intracel·lular comuna Toll-IL1R (TIR). El desenvolupament d’una MPI greu (MPIG) podria estar condicionat per polimorfismes genètics (SNPs) en regions crítiques de la via de senyalització comuna TIR. Aquests SNPs podrien influenciar també l’evolució i el pronòstic de la MPI. La determinació de la pèrdua d’expressió de la L-selectina (CD62L) “in vivo” en la superfície dels granulòcits

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6

Ventura, Marcielle Teixeira. "Emulsões pediátricas de artesunato associado com cloridrato de mefloquina no tratamento da malária: desenvolvimento e estudo de estabilidade." Niterói, 2017. https://app.uff.br/riuff/handle/1/3350.

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Submitted by Biblioteca da Faculdade de Farmácia (bff@ndc.uff.br) on 2017-04-17T18:14:43Z No. of bitstreams: 1 Ventura, Marcielle Teixeira [Dissertação, 2014].pdf: 1365184 bytes, checksum: 3d4c74cf63404132c709dcde62ba0960 (MD5)<br>Made available in DSpace on 2017-04-17T18:14:43Z (GMT). No. of bitstreams: 1 Ventura, Marcielle Teixeira [Dissertação, 2014].pdf: 1365184 bytes, checksum: 3d4c74cf63404132c709dcde62ba0960 (MD5)<br>A Malária é uma doença tropical muito importante em saúde pública devido às altas taxas de morbidade e mortalidade no mundo. Essa doença ocorre principalmente nas regi

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7

Nweneka, Chidi Victor. "Chloroquine as a therapeutic option for mild post malaria anaemia." Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/2622/.

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Background: The relative importance of malaria anaemia as a cause of childhood morbidity and mortality varies between and within regions. However, malaria anaemia remains an important cause of childhood morbidity and mortality. It has been estimated that globally, severe malaria anaemia occurs 1.42 to 5.66 million times per annum and kills an estimated 190,000 to 974,000 under-5 children. Studies from different countries endemic for malaria have emphasised the importance of anaemia in malaria-associated morbidity and mortality. Most of these studies have conclusively shown that severe malaria

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8

Launes, Montaña Cristian. "Grip A (H1N1) PDM09: Malaltia moderada i greu en el pacient pediàtric. Utilitat de la càrrega viral com a biomarcador de gravetat." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/91062.

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INTRODUCCIÓ L’abril de 2009 s’identifica un nou virus de la grip, l’A (H1N1) pdm09, en humans. El juny del mateix any, l’Organització Mundial de la Salut declara l’estat de pandèmia a nivell mundial. La malaltia pel nou virus va afectar centenars de nens al nostre medi durant la temporada 2009-2010. OBJECTIUS - Descriure l'espectre de malaltia per grip A (H1N1) pdm09 moderat i greu (aquells casos que requeriren ingrés en un hospital pediàtric de tercer nivell) en la població pediàtrica en el nostre medi. - Descriure la malaltia per grip A (H1N1) pdm09 en pacients pediàtrics en tract

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9

Bautista, Rodríguez Carles. "Relació entre la malaltia pneumocòccica invasiva i el dèficit genètic de MBL (mannose-binding lectin)." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/471529.

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INTRODUCCIÓ. La susceptibilitat a la malaltia pneumocòccica invasiva (MPI) es correlaciona amb l’edat i els nens són el grup amb major inicidéncia de malaltia. El paper del sistema immunològic innat, concretament la MBL (mannose-binding lectin) i la seva relació amb la MPI no està ben definit. OBJECTIUS. Els objectius d’aquesta tesi doctoral son determinar la prevalença de genotips responsables de nivells baixos de MBL sèrica en pacients amb MPI segons els grup d’edat i el potencial invasiu associat al serotip de pneumococ. MATERIAL I MÈTODE. Es realitzen dos estudis. El primer és un

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10

Lionetti, Maria Elena. "Epoca di introduzione del glutine e rischio di malattia celiaca: trial clinico multicentrico, prospettico, randomizzato in lattanti ad alto rischio di malattia. Risultati preliminari." Thesis, Università degli Studi di Catania, 2011. http://hdl.handle.net/10761/242.

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Background: Negli ultimi anni, numerosi studi epidemiologici hanno suggerito che l'epoca d'introduzione del glutine nella dieta cosi' come la modalita' di allattamento, possono giocare un ruolo importante nello sviluppo della malattia celiaca (MC). Tuttavia, questi studi caso-controllo mancano di consistenza, probabilmente a causa del disegno retrospettivo. Scopo dello studio: Valutare il ruolo a) dellÃ Ã Â¢ epoca d'introduzione del glutine sull'incidenza della MC in una larga coorte di lattanti ad alto rischio di malattia (parenti di primo grado di celiaci); b) di altri fattori ambientali,

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11

Selva, Jové Laura. "Real-time PCR per a la vigilància epidemiològica de la malaltia pneumocòccica invasiva (MPI) en pacients pediàtrics." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/92298.

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Streptococcus pneumoniae (S. pneumoniae) és un colonitzador habitual del tracte respiratori superior dels humans. Es tracta d’un patogen comú de l’espècie humana que presenta una elevada taxa de morbiditat i mortalitat arreu del món. El bacteri pot causar otitis mitjana, sinusitis o infeccions de tracte respiratori superior, (per contigüitat) però també pot causar malaltia invasiva, quan habita en un territori habitualment estèril, produint pneumònia, bacterièmia, septicèmies i meningitis, entre d’altres. La malaltia pneumocòccica és un important problema de salut pública i és la principal

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12

CASCIANO, FABIO. "Aspetti immunologici di pazienti pediatrici con immunodeficienze primitive." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2010. http://hdl.handle.net/2108/1278.

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La sindrome di DiGeorge (DGS) è causata da una delezione in emizigosi del locus 22q11.2 responsabile di difetti embriogenetici che determinano l’alterazione del timo e delle ghiandole paratiroidee, difetti cardiaci e anomalie facciali caratteristiche. In molti pazienti affetti da questa sindrome, il difetto immunitario è principalmente del compartimento T, sebbene siano state riportate anche anomalie quali disgammaglobulinemia, deficit di IgA e di cellule B della memoria. Sulla base dei dati immunologici, i pazienti DGS sono classificati in DGS completi (cDGS) e DGS parziali (pDGS): i cDGS cor

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13

SELENOU, NGOMSI NGANKAM MATHURIN. "Le syndrome de kawasaki ou syndrome adeno-cutaneo-muqueux : a propos de 114 enfants hospitalises en pediatrie de 1983 a 1989." Angers, 1990. http://www.theses.fr/1990ANGE1034.

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14

McQuilkin, Patricia A. "Characterization of Severe Malaria in Liberian Children 5 Years Old and Younger." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/896.

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Malaria continues to be a challenging problem in the developing world, and the burden of this life threatening disease continues to be borne by young children living in Sub Saharan Africa. One of the biggest challenges to the prevention and control of this problem lies in accurately diagnosing malaria, and distinguishing it from the many other febrile illnesses which present in children in this age group. Liberia is a West African country with a high burden of malaria. Very little is known about the presentation of severe malaria in children aged 5 years old and younger in Liberia. We undertoo

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McQuilkin, Patricia A. "Characterization of Severe Malaria in Liberian Children 5 Years Old and Younger." eScholarship@UMMS, 2005. http://escholarship.umassmed.edu/gsbs_diss/896.

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Malaria continues to be a challenging problem in the developing world, and the burden of this life threatening disease continues to be borne by young children living in Sub Saharan Africa. One of the biggest challenges to the prevention and control of this problem lies in accurately diagnosing malaria, and distinguishing it from the many other febrile illnesses which present in children in this age group. Liberia is a West African country with a high burden of malaria. Very little is known about the presentation of severe malaria in children aged 5 years old and younger in Liberia. We undertoo

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16

VARNIER, GIULIA CAMILLA. "Sviluppo e validazione di nuove misure di valutazione dello stato di malattia nella dermatomiosite giovanile." Doctoral thesis, Università degli studi di Genova, 2019. http://hdl.handle.net/11567/945542.

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17

TIBALDI, JESSICA. "SVILUPPO E INIZIALE VALIDAZIONE DI UNO SCORE COMPOSITO DI ATTIVITA’ DI MALATTIA PER L’ARTRITE IDIOPATICA GIOVANILE SISTEMICA." Doctoral thesis, Università degli studi di Genova, 2021. http://hdl.handle.net/11567/1046758.

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Objective. To develop a composite disease activity score for systemic juvenile idiopathic arthritis (sJIA) and to provide preliminary evidence of its validity. Methods. The systemic Juvenile Arthritis Disease Activity Score (sJADAS) was constructed by adding to the four items of the original JADAS a fifth item aimed to quantify the activity of systemic features. Validation analyses were conducted on patients with definite or probable/possible sJIA enrolled at first visit or at the time of a flare, who had active systemic manifestations, which should include fever. Patients were reassessed 2 w

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18

Cuzzubbo, Daniela. "Malattia Veno-Occlusiva epatica come complicanza del trattamento del Tumore di Wilms: l'esperienza di due centri pediatrici italiani." Doctoral thesis, Università di Catania, 2012. http://hdl.handle.net/10761/1202.

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ABSTRACT La malattia Veno-Occlusiva epatica (VOD, Veno-Occlusive Disease) è una ben nota complicanza del Trapianto di Cellule Staminali Emopoietiche (TCSE). Si manifesta di solito entro le prime 3-4 settimane dal trapianto e ha una incidenza, nei pazienti pediatrici, di circa il 10-20% La VOD è stata però riportata anche in pazienti affetti da tumore solido, in particolare rabdomiosarcoma e Tumore di Wilms, sottoposti a trattamento chemioterapico a base di actinomicina D . L incidenza di VOD nei pazienti affetti da tumore di Wilms varia dal 1.2% al 8% e sembra essere associata alla presenza d

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19

PUGNETTI, LETIZIA. "IDENTIFICAZIONE DI MARCATORI MOLECOLARI DI MALATTIA E DI RISPOSTA ALLA TERAPIA IN PAZIENTI PEDIATRICI AFFETTI DA MALATTIE INFIAMMATORIE CRONICHE INTESTINALI." Doctoral thesis, Università degli Studi di Trieste, 2021. http://hdl.handle.net/11368/2997559.

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Le malattie infiammatorie croniche intestinali (MICI) sono malattie caratterizzate da una condizione cronica immuno-mediata del tratto gastrointestinale che includono il morbo di Crohn e la rettocolite ulcerosa. Le MICI che colpiscono pazienti pediatrici sono di particolare interesse poiché la loro incidenza è in aumento e, anche se vengono utilizzate strategie farmacologiche diverse, il trattamento ottimale è lungi dall'essere raggiunto. Nella prima parte del progetto di tesi è stato studiato il ruolo dell'lncRNA GAS5, mettendo in evidenza il suo possibile coinvolgimento nel processo di pato

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20

Mencarelli, Francesca <1976&gt. "Studio della funzione cardiaca e della massa ventricolare sinistra mediante ecocardiografia convenzionale e tissue doppler imaging in una popolazione pediatrica con malattia renale cronica in terapia conservativa e sostitutiva." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4617/1/mencarelli_francesca_tesi.pdf.

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Background: Cardiovascular disease (CVD) is a common cause of morbidity and mortality in childhood chronic kidney disease (CKD). Left ventricular hypertrophy (LVH) is known to be one of the earliest events in CVD development. Left ventricular diastolic function (DF) is thought to be also impaired in children with CKD. Tissue Doppler imaging (TDI) provide an accurate measure of DF and is less load dependent than conventional ECHO. Aim: To evaluate the LV mass and the DF in a population of children with CKD. Methods: 37 patients, median age: 10.4 (3.3-19.8); underlying renal disease: hypo/dys

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Mencarelli, Francesca <1976&gt. "Studio della funzione cardiaca e della massa ventricolare sinistra mediante ecocardiografia convenzionale e tissue doppler imaging in una popolazione pediatrica con malattia renale cronica in terapia conservativa e sostitutiva." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4617/.

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Background: Cardiovascular disease (CVD) is a common cause of morbidity and mortality in childhood chronic kidney disease (CKD). Left ventricular hypertrophy (LVH) is known to be one of the earliest events in CVD development. Left ventricular diastolic function (DF) is thought to be also impaired in children with CKD. Tissue Doppler imaging (TDI) provide an accurate measure of DF and is less load dependent than conventional ECHO. Aim: To evaluate the LV mass and the DF in a population of children with CKD. Methods: 37 patients, median age: 10.4 (3.3-19.8); underlying renal disease: hypo/dys

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RINALDI, MARIANGELA. "Sviluppo di un tool automatico per l’individuazione con risonanza magnetica del livello di attività di malattia nei pazienti affetti da artrite idiopatica giovanile in remissione clinica." Doctoral thesis, Università degli studi di Genova, 2021. http://hdl.handle.net/11567/1046912.

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INTRODUZIONE Il principale obiettivo del trattamento dei pazienti affetti da Artrite Idiopatica Giovanile (AIG) è quello di indurre la remissione clinica della malattia, fondamentale per prevenire la progressione del danno articolare e la conseguente disabilità funzionale. Lo stato di remissione clinica viene valutato dal medico sulla base dell’esame obiettivo (sinovite) del paziente e degli indici di infiammazione (VES o PCR). È noto, tuttavia, che l’esame clinico possa non essere sufficientemente sensibile per l’identificazione della presenza di sinovite sub clinica ossia non evidenziabil

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Nguyen, Thi Van Anh. "Monitoring of azathioprine therapy in pediatric population : relationship between pharmacokinetics pharmacodynamics in inflammatory bowel disease (IBD) and autoimmune hepatitis (AIH)." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10120.

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La présente étude a pour objectif de mettre en évidence l‘intérêt du suivi thérapeutique pharmacologique (STP) des métabolites thiopuriques en vue de l‘optimisation du traitement par l‘azathioprine chez les enfants atteints de maladie inflammatoire de l‘intestin et d‘hépatite autoimmune. Les travaux réalisés nous ont permis de montrer, en utilisant une analyse multi-niveaux, une corrélation significative entre la dose d‘azathioprine et les concentrations en 6-TGN et Me6-MPN ainsi qu‘avec le ratio Me6-MPN/6-TGN confortant l‘utilisation des métabolites pour ajuster la posologie d‘azathioprine ch

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Ilunga-Ilunga, Félicien. "Le paludisme grave de l'enfant: profil des ménages, aspects épidémio-cliniques, et analyse de coûts de prise en charge dans les hôpitaux de Kinshasa, République Démocratique du Congo." Doctoral thesis, Universite Libre de Bruxelles, 2015. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209063.

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Le paludisme grave de l’enfant est une maladie potentiellement mortelle dans de nombreuses zones tropicales et subtropicales. Sa prise en charge nécessite des moyens coûteux et pèse lourdement sur l’économie des ménages. En République Démocratique du Congo, les ménages sont obligés de débourser directement les frais de prise en charge, faute de la quasi-inexistence de la sécurité sociale. En dépit de la conférence d’Abidjan 2001, demandant aux chefs d’Etats africains de consacrer 15% des budgets nationaux à la santé, le budget alloué à la santé en RDC reste faible. La charge financière s’est t

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Gairí, Burgués Maria Alba. "Valoración de la madurez para la toma de decisiones sanitarias en menores afectos de enfermedad aguda y crónica en un contexto hospitalario." Doctoral thesis, Universitat de Lleida, 2020. http://hdl.handle.net/10803/669669.

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INTRODUCCIÓ: La participació de el menor en la presa de decisions és un aspecte clau en el nou marc ètic i legal de desenvolupament de la medicina actual. Aquesta participació s'ha de fer de manera progressiva i d'acord amb la maduresa de el menor. Per això, la valoració rigorosa de la mateixa s'erigeix com a punt clau per la presa de decisions sanitàries principalment en els menors amb malaltia crònica. Des de la llei 41/2002 d’autonomia del pacient del 14 de noviembre, s’ estableix que des dels 12 als 16 anys l'opinió en les decisions sobre la seva salut ha de ser escoltada abans que el seu

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Tchivandja, Quirino. "Cause delle morti materne per malattia ipertensiva della gravidanza nell'Ospedale generale materno infantile del Kilamba Kiaxi." Doctoral thesis, Università degli studi di Trieste, 2009. http://hdl.handle.net/10077/3217.

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2007/2008<br>Foi um estudo retrospectivo, descritivo que baseou-se na análise de 494 mortes maternasdas grávidas ocorridas nas diferentes Províncias de Angola, no período de cinco anos(2001-2005), com o diagnóstico de doença hipertensiva gravídica, baseado nos dadosestatísticos recolhidos na Direcção Nacional de Saúde Publica, Departamento da Saúde Reprodutiva do Ministério da Saúde e de 228 falecidas no mesmo período na MaternidadeLucrécia Paim em Luanda, comparada com outras patologias.Durante o período em estudo, Luanda foi a província onde ocorreram mais óbitos 335(67,8%) muitos deles ocor

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Mazzucato, Monica. "Criticità e prospettive nella programmazione dei servizi e degli interventi a favore delle persone con malattia rara." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425529.

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Rare disorders are a numerous group of pathologies, characterized by extreme heterogeneity and at the same time sharing some common characteristics, involving nearly all the ages and all the etiologies. Furthermore, rare disorders often represent chronic conditions; as regards natural history, they are characterized by adverse outcomes, in terms of disability and quality of life and in many cases lead to a long terminal illness phase. Rare disorders don't represent a defined nosological group; an exact list of these disorders shared by the majority doesn't exist, as it strictly depends on the

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Mazzotti, Elisa. "Nuove acquisizioni sulla storia naturale della cardiomiopatia aritmogena del ventricolo destro attraverso lo studio di soggetti in età pediatrica portatori di mutazioni nei geni-malattia." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3426451.

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BACKGROUND: Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a heart muscle disease characterized by myocardial atrophy and fibrofatty replacement, mainly involving he right ventricle (RV). However also the left ventricle (LV) can be involved in a significant number of cases. The pathologic substrate constitutes the anatomic basis both for re-entry phenomena, that can lead to onset of ventricular arrhythmias, and for morphological alterations of the RV. The clinical manifestations of disease usually appear between 10 and 20 years of age. ARVC/D has been proved to have a g

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LOGANES, CLAUDIA. "Microbiota e difetto immune nella patogenesi della malattia di Crohn: sviluppo di modelli per lo studio di possibili approcci correttivi non immuno-soppressivi." Doctoral thesis, Università degli Studi di Trieste, 2017. http://hdl.handle.net/11368/2908136.

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La malattia di Crohn(MC)è una malattia infiammatoria cronica dell’intestino che può colpire qualsiasi tratto del tubo digerente. Nonostante siano stati effettuati numerosi studi, la patogenesi della MC non è ancora chiara e non si dispone di trattamenti in grado di guarire stabilmente la malattia. Il sistema immunitario innato sembra giocare un ruolo fondamentale nella patogenesi: è stato osservato infatti un coinvolgimento di alcuni geni dell’immunità innata ed uno squilibrato rapporto tra sistema immune mucosale e microbiota intestinale. Dati clinici e genetici portano a pensare che alla bas

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TESSER, ALESSANDRA. "PROFILO FUNZIONALE DI PAZIENTI CON LUPUS ERITEMATOSO SISTEMICO E CORRELAZIONE CON I MECCANISMI COINVOLTI IN DIVERSE FORME MONOGENICHE DELLA MALATTIA." Doctoral thesis, Università degli Studi di Trieste, 2018. http://hdl.handle.net/11368/2922621.

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Il lupus eritematoso sistemico (LES) rappresenta una complessa patologia multisistemica, all’interno del cui universo si possono spesso individuare eventi patogenetici diversi ma riconducibili a quadri clinici sovrapponibili. Una possibile caratteristica comune può considerarsi l’utilizzo improprio della risposta immunitaria agli acidi nucleici. Per comprendere il ruolo di questo tipo di risposta, ci siamo concentrati sullo studio delle Interferonopatie di tipo I, un gruppo di malattie monogeniche di recente definizione, causate da alterazioni nel meccanismo di riconoscimento e metabolismo deg

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Ghisleni, D. "EFFETTO DELLA DIETA PRIVA DI GLUTINE SU ADIPOSITA', PROFILO LIPIDICO E METABOLISMO GLUCIDICO IN BAMBINI AFFETTI DA MALATTIA CELIACA: STUDIO MULTICENTRICO CONDOTTO IN ITALIA E IN ISRAELE." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/217717.

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EFFECT OF A GLUTEN FREE DIET ON ADIPOSITY, LIPID PROFILE AND GLUCIDIC METABOLISM IN A COHORT OF CELIAC CHILDREN: MULTICENTRIC STUDY COMPARING ITALY AND ISRAEL Introduction. The classic symptoms of failure to thrive and diarrhea nowadays are infrequently seen in celiac disease (CD). Many patients present with normal or elevated body mass index (BMI) at diagnosis. Cardiovascular disease (CVD) have their roots in childhood. The evidences of an association between CD, gluten free diet (GFD) and CVD risk factors in children are limited. Aims and methods. Our aims were to define the trend of BMI z

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Campeggio, Mimma. "Prognostic Role of Minimal Residual Disease before and after Haematopoietic Stem Cell Transplantation in pediatric ALL patients and evaluation of droplet digital PCR applicability in pre-HSCT MRD monitoring." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3425313.

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Acute Lymphoblastic Leukemia (ALL) represents the most frequent cancer in childhood. Currently, more than 80% of children with ALL can be cured through intensive and risk-adapted chemotherapy protocols, but unfortunately, the remaining 20% ultimately relapse. Allogeneic hematopoietic stem cell transplantation (HSCT) is considered beneficial for approximately 10% of patients who are at high risk (HR) at frontline therapy according to the AIEOP-BFM protocol criteria, and for the majority of patients after ALL relapse. However, also after HSCT, relapse remains the leading cause of treatment failu

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Jeziorski, Éric. "Imputabilité des rétrovirus dans les pathologies présumées post infectieuses de l'enfant." Thesis, Montpellier 1, 2011. http://www.theses.fr/2011MON1T029/document.

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Introduction :Les rétrovirus infectieux des vertébrés sont regroupés en 7 genres : les Alpharétrovirus, les Bétarétrovirus, les Gammarétrovirus, les Deltarétrovirus, les Epsilonrétrovirus, les Lentivirus et les Spumavirus. Le Human T-cell Leukemia virus (HTLV), un deltarétrovirus, et l'Human Immunodeficiency Virus (HIV), un lentivirus, infectent l'homme. Des cas sporadiques d'infection par des spumavirus (virus Foamy) ont été décrits chez des personnes vivant en promiscuité avec des animaux infectés. Plusieurs éléments sont en faveur de l'existence de rétrovirus humains encore inconnus :-De no

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VERMA, ANIL KUMAR. "Identification of a New Biomarker for Celiac Disease and Other Gluten-Related Disorders." Doctoral thesis, Università Politecnica delle Marche, 2019. http://hdl.handle.net/11566/263700.

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Introduzione: I disturbi glutine-correlati sono rappresentati da un ampio spettro di disordini causati dal consumo di glutine contenuto nel grano e in altri cereali strettamente correlati, con una prevalenza globale del 5% circa. La malattia celiaca, un esempio di disturbo glutine-correlato, è un disordine immunomediato da cellule T indotto dall’assunzione di glutine in soggetti geneticamente predisposti. La prevalenza globale della malattia celiaca è almeno dell’1%. Ad oggi l’unico trattamento disponibile per la malattia celiaca è l’aderenza ad una dieta rigorosamente priva di glutine per tut

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Ribeiro, Maria-Hélène. "L’ajustement parental de la première année en contexte : le sentiment d’efficacité parentale et le soutien social pour faire face à des évènements ordinaires ou liés à une maladie abdominothoracique rare de l’enfant." Thesis, Université de Lille (2018-2021), 2021. http://www.theses.fr/2021LILUH058.

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Devenir parent est un évènement de vie majeur qui est souvent associé à des sentiments de bonheur mais qui peut aussi engendrer une détresse psychologique. Le contexte dans lequel s’effectue l’ajustement parental est défini par les caractéristiques du parent, de l’enfant et de l’environnement socio-culturel dans lequel le parent vit et qui influe sur son état de santé et son bien-être. Le contexte de la première année est particulièrement marqué par les nombreux défis et ajustements liés au développement et aux besoins spécifiques du jeune enfant. De plus, la naissance d’un enfant atteint d’un

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PILUDU, MARIA BONARIA. "Associazione tra i polimorfismi dei geni NOD2/CARD15, TLR-4, IL23R e GVHD, infezioni e mortalità precoce nel trapianto allogenico di cellule staminali ematopoietiche nella popolazione pediatrica sarda talassemica, ampliamento del progetto con lo studio molecolare di altri geni candidati." Doctoral thesis, Università degli Studi di Cagliari, 2016. http://hdl.handle.net/11584/266633.

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Recently single nucleotide polymorphisms (SNPs) of the genes NOD2-CARD15, IL23-R and TLR-4 have been showed to influence the risk for acute GvHD in patients who underwent to allogeneic hematopoietic stem cells (HSCs) transplantation. To investigate whether these genes play a role in the pathogenesis of GvHD also in the Sardinian population, 8 SNPs four for NOD2, two for TLR4 and two for IL23R in 86 recipients, their coupled donors and in 150 healthy Sardinians individualswere genotyped and the SNPs frequencies compared. The SNP rs2066842 of NOD2 gene was significantly increased in the group

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Martinato, Matteo. "Uno studio prospettico sull'infezione da Clostridium difficile nelle malattie infiammatorie croniche intestinali: fattori di rischio, tossino-tipi, sensibilità agli antibiotici, capacità di adesione e impatto sul successivo decorso della malattia." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423091.

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Clostridium difficile is a Gram positive bacterium rarely present in normal human gut flora that under certain conditions of intestinal dysbiosis, in patients treated with broad-spectrum antibiotics, in hospitalized patients, in immunocompromised subjects and elderly, can cause disease of variable severity referred to as Clostridium Difficile Associated Diarrohea (CDAD). Although in the past Clostridium difficile has been indicated as a possible causal factor in the development of inflammatory bowel disease (also known as IBD), nowadays it is more likely to believe that the IBD may be a risk f

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Bacchetta, Justine. "Atteinte osseuse et minérale chez l’enfant insuffisant rénal chronique : from bedside to bench." Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10169.

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La maladie rénale chronique (MRC) induit des anomalies du métabolisme phosphocalcique, avec des conséquences à la fois osseuses, vasculaires et biologiques. La prise en charge optimale de ces désordres représente un challenge quotidien pour le néphrologue pédiatre, à la fois sur le court terme (équilibre biologique) et sur le long terme (prévention des fractures, optimisation de la croissance et limitation de l’apparition des calcifications vasculaires). Peu d’outils sont actuellement disponibles pour évaluer ces atteintes, et de nouveaux outils prometteurs, à la fois biologiques (FGF23) et ra

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Toure, Hapsatou. "Etude des aspects médico-économiques liés au passage à échelle des interventions de prévention de la transmission mère-enfant du VIH (PTME) dans les pays à ressources limitées." Thesis, Bordeaux 2, 2012. http://www.theses.fr/2012BOR21917/document.

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Chaque année 330 000 (dont 300 000 en Afrique) nouvelles infections à VIH surviennent chez les moins de quinze ans – majoritairement par un mécanisme de transmission verticale d’une mère infectée à son enfant. Pourtant, des interventions efficaces pour réduire la transmission mère-enfant (TME) existent mais ne sont pas toujours disponibles en pratique de routine pour les femmes qui en ont besoin. L’agenda international en cours vise une élimination de l’infection pédiatrique de VIH – et le maintien des mères en vie – à l’horizon 2015. A la lumière de la crise économique mondiale, il apparait o

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Battistutta, Sara. "INTERVENTI PER FAVORIRE L'ADESIONE ALLE TERAPIE DELLE MALATTIE CRONICHE INFANTILI- Fibrosi Cistica, Diabete, Malattie Infiammatorie Croniche Intestinali, Celiachia -." Doctoral thesis, Università degli studi di Trieste, 2014. http://hdl.handle.net/10077/9980.

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2012/2013<br>Il Progetto di Dottorato “Interventi per favorire l'adesione alle terapie delle malattie croniche infantili - Fibrosi Cistica, Diabete, Malattie Infiammatorie Croniche Intestinali, Celiachia” prende origine dalla consapevolezza dell’importante impatto della presenza di una malattia cronica, anche e soprattutto in età evolutiva, per il paziente e la sua famiglia. Le patologie croniche incidono infatti sulla qualità di vita dei pazienti e dei familiari, “interrompendone” la quotidianità. Il programma terapeutico può influire sulla qualità di vita percepita, in quanto può causare dol

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Chausset, Aurélie. "Accès aux centres de rhumatologie pédiatrique pour les patients atteints d’arthrite juvénile idiopathique : parcours diagnostique et évaluation des facteurs prédictifs d’un retard de prise en charge." Electronic Thesis or Diss., Lyon 1, 2024. http://www.theses.fr/2024LYO10267.

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L'arthrite juvénile idiopathique (AJI) est la maladie rhumatologique pédiatrique chronique la plus fréquente. L’intérêt d’une prise en charge précoce et d’une orientation rapide vers un centre de rhumatologie pédiatrique (RP) a largement été démontré pour réduire le risque de lésions articulaires et/ou oculaires et améliorer la qualité de vie des enfants. Dans le monde, le délai d'accès (DA) médian au centre de RP varie de 3 à 10 mois, néanmoins il existe une grande variabilité avec des délais extrêmes de plusieurs années pour certains patients. Des travaux antérieurs ont porté sur l’identific

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Lévy, Eva. "Identification de causes génétiques du syndrome d’Evans pédiatrique." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB017/document.

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Le syndrome d'Evans est défini par l'existence concomitante ou séquentielle de cytopénies auto-immunes, le plus souvent, anémie hémolytique et thrombopénie immunologique. Chez l'enfant, il peut être secondaire à une infection, une maladie auto-immune systémique ou un déficit immunitaire primitif. Alternativement, chez une grande partie des patients, l'étiologie n'est pas clairement identifiée. Les patients atteints de syndrome d'Evans présentent parfois d'autres atteintes, telles une auto-immunité d'organe, une lymphoprolifération bénigne ou un déficit immunitaire. L'objectif de ce travail éta

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Mainardi, Chiara. "Detection of an immunological response against TEL/AML1 fusion protein." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3424771.

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Immunotherapy represents a therapeutic option for subgroups of paediatric patients with leukaemia who, despite the impressing advances of the last decades in the field, still show a poor prognosis because of high risk-disease or relapse. A deeper understanding of how the immune system physiologically recognizes and eradicates tumour cells is mandatory. Peptidic antigens are of great interest in the field of immunotherapy because they could be used as vaccines to boost immunity. TEL/AML1 mutant protein, whose sequence is known, is the result of a balanced t(12;21) translocation which gene

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Schmidt, Kristopher Lee. "The neuropathology of pediatric cerebral malaria." Thesis, 2005. http://hdl.handle.net/2429/16710.

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Cerebral Malaria (CM) results from a Plasmodium falciparum infection and is characterized by severe neurologic dysfunction, coma and death; it is responsible for the deaths of 1-2 million people annually and affects primarily sub-Saharan African children. Several theories have been proposed regarding the pathogenesis of pediatric CM, but a lack of basic information regarding the neuropathological features of this disease in children, and how these features relate to clinical findings and parasitological data, make it difficult to establish the relative role that any pathological mechanis

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Ramaprasad, Abhinay. "Studying Different Clinical Syndromes Of Paediatric Severe Malaria Using Plasma Proteomics." Thesis, 2012. http://hdl.handle.net/10754/248732.

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Background- Severe Plasmodium falciparum malaria remains one of the major causes of childhood morbidity and mortality in Africa. Severe malaria manifests itself as three main clinical syndromes-impaired consciousness (cerebral malaria), respiratory distress and severe malarial anaemia. Cerebral malaria and respiratory distress are major contributors to malaria mortality but their pathophysiology remains unclear. Motivation/Objectives- Most children with severe malaria die within the first 24 hours of admission to a hospital because of their pathophysiological conditions. Thus, along with anti-

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Bélard, Sabine Miriam [Verfasser]. "Efficacy, safety, tolerability and acceptability of two pediatric formulations of artesunate-mefloquine in African children with acute uncomplicated Plasmodium falciparum malaria / vorgelegt von Sabine Miriam Bélard." 2008. http://d-nb.info/987985221/34.

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Bbosa, Richard Serunkuma. "Caregivers' home-based management of fever in Uganda." Thesis, 2009. http://hdl.handle.net/10500/3649.

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Malaria is endemic in Uganda. The study attempted to determine how Ugandan caregivers managed home-based care of fever. Structured interviews were conducted with sixty caregivers of children under five. In 15 (25.0%) out of the 60 interviewed households, at least one child had reportedly died from malaria. Caregivers’ decisions were influenced by health education, family members, community leaders and other caregivers. Most caregivers knew about malaria, but lacked knowledge about its danger signs, and about the services of village drug distributors. Most caregivers initiated treatment for fe

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Cappuccio, Gerarda. "Sequenziamento dell’esoma in pazienti pediatrici con malattia senza diagnosi." Tesi di dottorato, 2020. http://www.fedoa.unina.it/13011/1/Tesi_dottorato_21.12.2019_sera_NBP_GC.pdf.

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Introduzione ed obiettivi. Dall’aprile 2016, la sezione di Pediatria dell’AOU Federico II partecipa al Telethon Undiagnosed Program (TUDP) che ha l’obiettivo di raggiungere una diagnosi molecolare in pazienti pediatrici con malattie genetiche senza diagnosi attraverso il sequenziamento dell’intero esoma (WES). Il programma ha arruolato pazienti senza diagnosi attraverso una rete nazionale di centri pediatrici. I pazienti con malattie genetiche senza diagnosi sono stati sottoposti a valutazione clinica ed i casi selezionati sono stati discussi in riunioni plenarie con altri clinici partecipanti

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PARISI, Pasquale. "Malattie Dismielinizzanti e Demielinizzanti. RMN Spetroscopica in 2 soggetti con Malattia di Pelizaeus-Merzbacher: la riduzione del picco di colina è suggestiva di "forma connatale"." Doctoral thesis, 1998. http://hdl.handle.net/11573/413461.

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PIETROPAOLI, NICOLETTA. "Screening salivare della malattia celiaca in bambini e adolescenti geneticamente predisposti." Doctoral thesis, 2022. http://hdl.handle.net/11573/1639507.

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Introduzione: La celiachia (CD) è un disordine multifattoriale in cui il test genetico è di rilevanza clinica fondamentale. La malattia, infatti, solo raramente si sviluppa in assenza di aplotipi HLA-DQ2 e/o HLA-DQ8. Il quadro clinico della CD è estremamente variabile e, spesso, i pazienti sono asintomatici; pertanto, è di fondamentale importanza un intervento di prevenzione mirato alla diagnosi precoce di malattia nei soggetti a rischio. Obiettivo: Screening salivare mediante determinazione degli anticorpi anti-transglutaminasi IgA (TGA-IgA) con metodica radioimmunologica (RIA) per la dia

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