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Relevant bibliographies by topics / Pediatric pharmacology / Dissertations / Theses

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Dissertations / Theses on the topic 'Pediatric pharmacology'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 August 2024

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1

Sun, Pei-Chen Angela. "Paediatric pharmacovigilance : utility of routinely acquired healthcare data." Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=225729.

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2

Belon, Howard Porter 1957. "TEACHERS' KNOWLEDGE AND ATTITUDES TOWARD CHILDREN'S MEDICATIONS." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/276341.

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3

Tang, Lisa Eng. "Age-associated hepatic drug transporter expression and its implications for pediatric pharmacotherapy." View the abstract Download the full-text PDF version, 2007. http://etd.utmem.edu/ABSTRACTS/2007-027-Tang-Index.html.

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Thesis (Ph.D. )--University of Tennessee Health Science Center, 2007.<br>Title from title page screen (viewed on June 19, 2008). Research advisor: Bernd Meibohm, Ph.D. Document formatted into pages (xiv, 100 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 96-100).

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4

Soderstrom, David. "Fuzzy logic modeling and intelligent sliding mode control techniques for the individualization of theophylline therapy to pediatric patients." Thesis, Georgia Institute of Technology, 1992. http://hdl.handle.net/1853/19097.

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5

Rohan, Jennifer M. "The Relationship of 6-Mercaptopurine Medication Adherence to Clinical Outcomes in Pediatric Cancer." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1416570460.

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6

Easton-Carter, Kylie 1973. "The consequences of drug related problems in paediatrics." Monash University, Dept. of Pharmacy Practice, 2001. http://arrow.monash.edu.au/hdl/1959.1/8988.

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7

Mack, Elizabeth H. "Propofol as a bridge to extubation in the pediatric intensive care unit." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1243354898.

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8

Lilley, Christine Megan. "Psychological predictors of children's pain and parents' medication practices following pediatric day surgery." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ56577.pdf.

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9

Kunac, Desirée L., and n/a. "Adverse drug events and medication errors in a paediatric inpatient population." University of Otago. Dunedin School of Medicine, 2005. http://adt.otago.ac.nz./public/adt-NZDU20060707.161220.

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Background. Medication-related patient injuries (adverse drug events, ADEs) are an important problem in all hospitalised populations; however, the potential for injury is reported to be greater in children than adults. Many ADEs are due to error and therefore could be prevented. Data regarding the risk factors (or predictors) for these events in paediatric inpatients is limited. It was hypothesised that "identification of risk factors for ADEs and medication errors in the paediatric inpatient setting will inform likely prevention strategies". Aims. To determine the frequency, nature and risk

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10

Allen, Paul H. "Pharmacological Management of Acute Dental Pain in Children; Attitudes and Beliefs of Caregivers." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1242045989.

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11

Añez, Valdez Arletta. "Resistencia a las drogas antimaláricas en Bolivia." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/587143.

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La cloroquina (CQ) sigue siendo el medicamento de primera línea en todo el mundo para el tratamiento de la malaria por Plasmodium vivax. La dosis recomendada por la OMS es de 25 mg/kg/peso, independientemente de la edad del paciente. Por otro lado, la farmacocinética y la farmacodinámica de los medicamentos; diferente en los niños en relación que los adultos, puede influir en la concentración del fármaco en la sangre y convertirse en factor de riesgo para el fracaso terapéutico y /o resistencia a CQ. Objetivo: Evaluar la eficacia terapéutica de la cloroquina en infecciones por Plasmodium viva

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12

Pagerols, Teixidó Mireia. "Bases genètiques del trastorn per dèficit d'atenció amb hiperactivitat i de la resposta farmacològica al metilfenidat." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/665201.

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El trastorn per dèficit d’atenció amb hiperactivitat (TDAH) és un trastorn del neurodesenvolupament caracteritzat per símptomes d’inatenció i/o hiperactivitat/impulsivitat. Nombrosos estudis suggereixen un important component genètic en l’etiologia del TDAH, amb una heretabilitat estimada del 70-80%. Tanmateix, la majoria de variants genètiques identificades només expliquen una petita proporció de la variabilitat fenotípica observada i la seva associació, en general, no ha estat replicada consistentment. A més, s’han descrit diversos factors ambientals que tendeixen a incrementar el risc de pr

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13

Reynolds-Wilcox, Wendy Lee. "The impact of child life non-pharmacologic pain interventions on pediatric patient's pain perception in the emergency department." CSUSB ScholarWorks, 2004. https://scholarworks.lib.csusb.edu/etd-project/2645.

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The purpose of this current study is to examine the impact of non-pharmacologic pain interventions administered by trained Child Life professionals in an emergency department on pain perception in children. Results showed no significant decrease in children's pain report during the medical procedure compared to before the medical procedure. However, pain after the medical procedure is significantly less than pain during the medical procedure.

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14

Orr, Serena. "The Pharmacologic Prophylaxis of Pediatric Migraine: A Systematic Review, Survey and Design of a Randomized Controlled Trial." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35109.

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Objectives: 1) To describe the state of the evidence for interventions in pediatric migraine, 2) to survey experts regarding non-inferiority margins in migraine research and 3) to design a clinical trial in this area of research. Methods: A systematic review was carried out to identify randomized, placebo-controlled trials of pharmaceutical and nutraceutical interventions used to prevent migraine in children and adolescents, using Cochrane methods. Secondly, neurologists with expertise in Headache Medicine were invited to participate in a survey regarding their opinions on non-inferiority m

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15

Provenza, Bernal Nora. "Caracterización y estudio de estabilidad de fórmulas magistrales líquidas de administración oral." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/283660.

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La falta de disponibilidad de presentaciones comerciales adecuadas para la posología pediátrica todavía supone un gran problema, especialmente relevante en medicamentos con margen terapéutico estrecho, ya que puede derivar en infra o sobredosificaciones; o en niños que sufren enfermedades crónicas, condenados a tomar medicamentos mal adaptados y sufrir las consecuencias que ello supone; o en las ocasiones en las que se presentan casos de intolerancias o alergias hacia determinados excipientes. Todo ello obliga a realizar un gran número de fórmulas magistrales. Evidentemente, para solventa

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16

Mollel, Happiness. "Development and assessment of azithromycin paediatric suppository formulations." Thesis, Rhodes University, 2006. http://eprints.ru.ac.za/1345/.

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17

McWilliam, Stephen. "Novel approaches to aminoglycoside-induced nephrotoxicity in children." Thesis, University of Liverpool, 2015. http://livrepository.liverpool.ac.uk/2049479/.

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Background: Aminoglycoside antibiotics are commonly used in paediatric clinical practice, especially for the treatment of neonatal sepsis and pulmonary exacerbations in cystic fibrosis (CF). However, megalin-mediated endocytosis of the aminoglycosides by renal proximal tubule epithelial cells leads to toxicity, and may result in acute kidney injury and chronic kidney disease. Current approaches to identify and prevent toxicity are limited. Several novel biomarkers have shown utility in preclinical studies for the identification of aminoglycoside-induced nephrotoxicity, but clinical data and an

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18

Gregson, Rachael Kathleen. "Characterisation of manual chest physiotherapy and respiratory response in mechanically ventilated children." Thesis, University of Southampton, 2008. https://eprints.soton.ac.uk/67620/.

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Chest physiotherapy is integral to the management of mechanically ventilated children and previous research has confirmed that chest wall vibrations are the manual techniques used most frequently by physiotherapists in this population. Chest wall vibrations involve the application of a compressive force to the chest during expiration, with the aim of removing accumulated secretions and improving lung aeration. However, these techniques are largely unquantified and may vary greatly between practitioners and clinical units, with any significance of such variability remaining unknown. In order to

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19

Vassalos, Tony. "End organ effects of paediatric cardiopulmonary bypass." Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/2385/.

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Despite the scientific, technological and surgical improvements of the past 50 years organ dysfunction following elective paediatric cardiac surgery utilising cardiopulmonary bypass continues to account for increased complications, often leading to a protracted course in hospital with a longer stay in intensive care and the potential for irreversible organ damage long term. Furthermore, paediatric cardiac surgeons are routinely undertaking more complex operations with a shift from palliation to early correction. This has resulted in younger children being subjected to longer periods on the byp

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20

Goss, Kevin Colin William. "Dynamic surfactant metabolism in preterm infants." Thesis, University of Southampton, 2012. https://eprints.soton.ac.uk/361465/.

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Exogenous surfactant therapy has dramatically improved survival in extremely preterm infants, however the turnover of exogenous and synthesis of endogenous surfactant components are still poorly understood in this group. Additionally there is evidence for this patient group that improving nutrition improves long-term outcomes in respiratory function, growth and neurodevelopment. Phosphatidylcholine (PC) is the dominant phospholipid in both surfactant and in plasma and can be synthesised from choline by one of two pathways: the CDPcholine pathway, which is present in all nucleated cells, or by

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21

Lefort, Daniella. "Formes galénique et spécialités administrées chez l'enfant." Paris 5, 1991. http://www.theses.fr/1991PA05P034.

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22

Psychouli, Pavlina. "Modified constraint-induced movement therapy in children with congenital hemiplegic cerebral palsy." Thesis, University of Southampton, 2008. https://eprints.soton.ac.uk/71895/.

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One new treatment strategy for children with hemiplegic cerebral palsy (CP) is constraint-induced movement therapy (CIMT). CIMT combines restraint of the less affected upper extremity and intensive exercise with the affected limb. CIMT has been shown to be effective in adults following stroke but it is not clear whether or not CIMT can readily be incorporated into clinical practice either with adults or children. An intervention that may be more practical involves the restraint element of CIMT without additional exercise (Forced use therapy-FUT). FUT has been only sparsely investigated, especi

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23

Vieillefosse, Laurence. "Préparations magistrales pédiatriques : standardisation des dosages." Paris 5, 1997. http://www.theses.fr/1997PA05P182.

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24

Balajadia, Jr Arturo Dillomes, and Jr Arturo Dillomes Balajadia. "Effects of Fresh Frozen Plasma on Post-Op Bleeding in Infants Undergoing Cardiac Surgery with Cardiopulmonary Bypass." Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/620837.

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Severe congenital heart disease (CHD) is diagnosed in the United States 147.4 times per 100,000 live births, excluding still births and abortions^1. With the advancement of diagnostic methods, prenatal care, and screening modalities, the total CHD birth prevalence has increased substantially^2. In turn, this increases the number of cardiac surgery cases. With the advancement of technology and cardiac surgery, smaller and younger patients are undergoing more complex cardiac procedures that involve cardiopulmonary bypass (CPB). Neonates and infants undergoing CPB are susceptible to adverse effec

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25

Mercadé, Frutos Débora. "Nova preparació pediàtrica per al tractament de la tuberculosi." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/664643.

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La tuberculosi és una infecció bacteriana causada per un micobacteri anomenat Mycobacterium tuberculosis. Actualment és la primera causa mundial de mortalitat causada per un agent infecciós fins i tot per sobre de la Síndrome d’Immunodeficiència Adquirida (SIDA). Segons l’informe anual sobre tuberculosi realitzat per l‘Organització Mundial de la Salut (OMS), a l’any 2016 10,4 milions de persones van emmalaltir de tuberculosi, 1,3 milions van morir per aquesta malaltia dels quals 130.000 foren nens. El tractament d’elecció per a la tuberculosi infantil és la combinació de rifampicina, isonia

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26

Olagunju, Adeniyi. "Pharmacogenetics of antiretroviral drugs used for prevention of mother-to-child transmission of HIV during pregnancy and lactation." Thesis, University of Liverpool, 2015. http://livrepository.liverpool.ac.uk/2035139/.

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The use of antiretroviral therapy (ART) during pregnancy and lactation has significantly reduced the rate of mother-to-child transmission (MTCT) of HIV. However, pregnancy is known to affect the pharmacokinetics of many drugs, including key antiretroviral (ARV) drugs. In addition, ARV use during lactation raises questions about unintended exposure of breastfed infants to maternal drugs through breast milk. For drugs with significant genetic contribution to observed pharmacokinetic variability, we hypothesised that polymorphisms in drug disposition genes may accentuate or attenuate pregnancy-in

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27

Nagy, Sonia. "Le pharmacien face au vide thérapeutique pédiatrique." Paris 5, 1996. http://www.theses.fr/1996PA05P084.

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28

Rona, Véronique. "Prescriptions d'antiémétiques en oncologie pédiatrique." Paris 5, 1998. http://www.theses.fr/1998PA05P150.

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29

Rey, Jean-Baptiste. "Stabilité galénique de formules-types de mélanges ternaires destinés à la nutrition parentérale en pédiatrie/ Jean-Baptiste Rey." Paris 5, 1999. http://www.theses.fr/1999PA05P100.

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30

Valette, Catherine. "Les modalités de prescription des médicaments dans un hôpital pédiatrique." Paris 5, 1993. http://www.theses.fr/1993PA05P074.

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31

Koeniguer, Sylvie. "Mise au point d'une méthode de dosage par CLHP de la daunorubicine, de l'idarubicine et de leurs métabolites, daunorubicinol et idarubicinol, dans les prélévements pédiatriques." Paris 5, 1998. http://www.theses.fr/1998PA05P122.

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32

Moty, Aymeric. "Le chlorure de béthanéchol pour usage pédiatrique en France : place et intérêt." Paris 5, 1998. http://www.theses.fr/1998PA05P219.

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33

Lefort, Anne. "Le conseil pédiatrique à l'officine : bases théoriques et données pratiques." Paris 5, 1991. http://www.theses.fr/1991PA05P032.

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34

Darres, Céline. "Conservation des formes buvables multidoses pédiatriques." Paris 5, 1998. http://www.theses.fr/1998PA05P239.

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35

Senta-Loys, Zoé. "Films orodispersibles de tétrabénazine pour l’administration pédiatrique." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1304/document.

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Lors de cette dernière décennie, le développement de formes pharmaceutiques innovantes permettant d'améliorer l'efficacité, la sécurité et l'acceptabilité des médicaments pédiatriques est en pleine croissance. Les films orodispersibles (ODF) appartiennent à ces nouvelles formes galéniques améliorant la compliance des patients. Ils sont constitués d'une matrice de polymère hydrophile dans laquelle un ou des principe(s) actif(s) (PA) sont dissous ou dispersés. Après dépôt de l'ODF sur la langue ou dans la cavité buccale, la matrice se désagrège libérant le PA pour une action locale ou systémique

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36

Newall, Fiona Helen. "Unfractionated Heparin therapy in paediatrics /." 2009. http://repository.unimelb.edu.au/10187/5735.

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Unfractionated heparin (UFH) therapy is frequently used in tertiary paediatric healthcare facilities despite a lack of paediatric-specific research informing the optimal therapeutic intensity, monitoring recommendations or side-effect-profile in infants and children. As a result, the majority of clinical recommendations regarding UFH management in children have been extrapolated from adult evidence. The process of developmental haemostasis, in association with the variable pathogenesis of thromboembolic disease (TED) in children compared to adults, suggests that extrapolation of adult guidel

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37

Garcia, Bournissen Facundo. "Development of Novel Methodologies for the Evaluation of Fetal and Pediatric Drug Exposure." Thesis, 2011. http://hdl.handle.net/1807/27579.

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Passive exposure of children to drugs is common, but difficult to ascertain as direct studies are in many cases not possible, and currently available indirect measures of drug exposure, such as maternal reports, are likely to be inaccurate. Novel, indirect methods to evaluate drug exposure in the uterus and early life are needed, and may provide risk estimates that can be later correlated with clinical outcomes. In the studies presented here, I have applied novel methods such as measurement of hair drug concentrations and population pharmacokinetics modeling and simulation to evaluate fetal a

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38

Lapeyraque, Anne-Laure. "Nouveaux outils de pharmacodynamie des immunosuppresseurs chez des receveurs pédiatriques de greffe d’organe." Thèse, 2012. http://hdl.handle.net/1866/9977.

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L’immunosuppression optimale après greffe d’organe solide est une balance délicate et propre à chaque individu entre le risque de rejet et les risques liés à une surexposition au traitement immunosuppresseur. L’évaluation de la fonction résiduelle des lymphocytes T après stimulation par un mitogène (pharmacodynamie effective) devrait permettre de mesurer l’effet direct des médicaments immunosuppresseurs sur leur cible. Nous avons étudié différents paramètres de pharmacodynamie effective chez 34 receveurs pédiatriques de greffe d’organes solides traités par tacrolimus et mycophénolate. Les tes

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39

Carpenter, Zachary Wayne. "Structure Function Analysis of Drug Resistance Driver Mutations in Acute Lymphoblastic Leukemia." Thesis, 2017. https://doi.org/10.7916/D8S46XQD.

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Acute Lymphoblastic Leukemia (ALL) is an aggressive hematologic tumor and is the most common malignancy in children (Horton and Steuber 2014). This disease is characterized by the infiltration of bone marrow by malignant immature lymphoid progenitor cells and is invariably fatal without treatment. Although multi-agent combination chemotherapy is curative in a significant fraction of ALL patients, treatment currently fails in approximately 20% of children and up to 50% of adults with ALL, making relapse and drug resistance the most substantial challenge in the treatment of this disease(Fieldin

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40

Samson, Marie-Ève. "Essai clinique randomisé comparant la méthadone et la morphine pour la prévention du syndrome de sevrage aux opiacés en pédiatrie." Thèse, 2019. http://hdl.handle.net/1866/23623.

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Introduction : La tolérance induite par l’utilisation prolongée des opiacés peut se traduire par un syndrome de sevrage aux opiacés (SDSO). Il n’existe aucun consensus sur la méthode idéale de sevrage des opiacés pour prévenir le SDSO chez la clientèle des soins intensifs pédiatriques (SIP). L’objectif de cette étude était de comparer l’efficacité de deux stratégies de sevrage des opiacés, à savoir la méthadone et la morphine administrées par voie entérale, à prévenir le SDSO. Devis : Essai clinique randomisé à double aveugle chez les enfants sous ventilation mécanique hospitalisés aux SIP.

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41

Menezes, Catarina Mont´Alverne De Sequeira Lemos De. "O papel do farmacêutico clínico na terapêutica farmacológica em pediatria." Master's thesis, 2014. http://hdl.handle.net/10437/5848.

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orientação: Liliana Pires Antunes Castanheira de Carreiro Mendes<br>A intervenção do farmacêutico clínico na população pediátrica implica uma abordagem terapêutica específica, consoante a idade e o fármaco considerado. A pesquisa da dose e regime posológico; a escolha da forma farmacêutica adequada; as possíveis técnicas de administração, bem como a farmacovigilância implícita, são alguns dos cuidados a ter em conta, de modo a garantir a segurança e eficácia do tratamento. Tendo em conta todos estes fatores, a União Europeia tem vindo a reconhecer este grupo como vulnerável e distinto d

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42

Ballard, Ariane. "Efficacité d’un dispositif combinant le froid et la vibration pour la gestion de la douleur d’enfants lors de procédures impliquant des aiguilles dans les services d’urgence : un essai clinique randomisé de non-infériorité." Thesis, 2019. http://hdl.handle.net/1866/24247.

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Les procédures impliquant des aiguilles sont la plus importante source de douleur chez les enfants. Considérant qu’il est impossible d’éliminer complètement la douleur ressentie lors de procédures douloureuses, il est de la responsabilité professionnelle de l’infirmière d’assurer sa gestion à l’aide d’interventions non-pharmacologiques et/ou pharmacologiques. Les interventions actuellement disponibles pour le soulagement de la douleur procédurale des enfants nécessitent beaucoup de temps ou de personnel, ce qui représente des barrières à leur implantation dans les services d’urgence. Par consé

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