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Journal articles on the topic 'Pei shen zhi du'

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Published: 4 June 2021
Last updated: 15 February 2022

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1

Wang, Yahan, Chunxiang Liu, Hui Wang, Yin Jiang, Pengwen Wang, and Hongcai Shang. "Systematic Review of Basic Research on Alzheimer’s Disease with Shen Zhi Ling Oral Liquid." Evidence-Based Complementary and Alternative Medicine 2019 (April 21, 2019): 1–10. http://dx.doi.org/10.1155/2019/8216714.

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Objective. The present report systematically reviewed the basic research of Shen Zhi Ling oral liquid (Tiao Xin preparation) treatment on Alzheimer’s disease (AD). Methods. CNKI, Wanfang, and VIP were searched, and the literature was selected according to inclusion and exclusion criteria. Data were extracted, and descriptive analysis was used. Results. Twenty-four articles were included, all of which were published as “Tiao Xin preparation.” There were seven types of AD models involved. The mechanism of action of Shen Zhi Ling oral liquid in the treatment of AD primarily included suppression of Aβ deposition and tau hyperphosphorylation, regulation of multiple neurotransmitters, improvement in energy metabolism, and promotion of the expression of autophagy-related and learning-memory-associated proteins. Conclusions. AD is a complex disease caused by multiple factors. Shen Zhi Ling oral liquid exhibited multiple and multitarget effects and great potential for treating AD. The continuous development of molecular biology and related disciplines will further elucidate the mechanism of Shen Zhi Ling oral liquid intervention in AD.
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Jiang, Wenwen, Xiaoyan Liu, Mei Su, Hengchang Zang, Yingzi Zeng, and Lei Nie. "Chromatographic fingerprint based on serially coupled columns combined with multiple-component quantitation with a single reference standard for quality evaluation of Shen–Zhi–Ling oral liquid." Analytical Methods 11, no. 3 (2019): 367–74. http://dx.doi.org/10.1039/c8ay01744a.

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Yong, Zhi, Huo Xin-hui, and Li Pan. "Efficacy observation of Zhi Shen Tiao Sui acupuncture method for depression after ischemic stroke." Journal of Acupuncture and Tuina Science 19, no. 3 (June 2021): 180–86. http://dx.doi.org/10.1007/s11726-021-1244-x.

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Pan, Weidong, Qiudong Wang, Shin Kwak, Yu Song, Baofeng Qin, Mingzhe Wang, and Yoshiharu Yamamoto. "Shen-Zhi-Ling Oral Liquid Improves Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/913687.

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We evaluated the effects of the traditional Chinese medicine (TCM) Shen-Zhi-Ling oral liquid (SZL) on the behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimer’s disease (AD). Among 98 patients with AD and BPSD enrolled (mean age, 57.2 ± 8.9 years old), 91 (M = 55,F = 36; mean age, 57.2 ± 9.7 years old) completed the study. Patients took either SZL (n=45) or placebo granules (n=46) in a double-blind manner for 20 weeks while maintaining other anticognitive medications unchanged. Changes in BPSD between week 0, week 10, week 20, and week 25 were assessed using the behavioral pathology in Alzheimer’s disease (BEHAVE-AD) rating scale and the neuropsychiatric inventory (NPI), detrended fluctuation analysis (DFA) represented by diurnal activity (DA), evening activity (EA), and nocturnal activity (NA) according to actigraphic recordings. SZL but not placebo oral liquid delayed the development of BPSD significantly according to the changes in some of the clinical scores and the EA and NA parameters of DFA at week 20 compared with week 0. No side effects were observed in laboratory tests. The results indicate that SZL might delay the development of BPSD in AD patients and thus is a potentially suitable drug for long-term use.
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Ying, Luo. "Cultural Values In The Novel "The Legend Of Condor Heroes" (Shen Diao Xia Lü) From Jin Yong." IJLECR - INTERNATIONAL JOURNAL OF LANGUAGE EDUCATION AND CULTURE REVIEW 2, no. 1 (June 6, 2016): 52–63. http://dx.doi.org/10.21009/ijlecr.021.16.

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The purpose of this research is to understand deeply about cultural values in the novel "The legend of Condor Heroes" from Jin Yong. This research uses qualitative method with structural semiotic approach. The results of this research showed the theme from this novel was about love, plot were progressive and dramatic, setting was in Dynasty of Zhong, and the point of view used third person. There were also found cultural values from semiotic aspects from Icon, indeks, and symbol they were independent, zhi (wise), control of emotion, Li (morality), Lian (pure heart), Ren (affection), Zhong (loyal), simplicity, Xiao (obedient), interflow with nature, accomplishing character, Yi (responsibility), praying, and obey rules of Budha.
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Sage, Richard J. "„ŠIRDIES SUNAIKINIMAS“: NE-SUVOKIMO IDEALAS LIEZI TEKSTE." Problemos, Suppl (January 20, 2017): 75. http://dx.doi.org/10.15388/problemos.2016.suppl.10356.

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Senovės kinų tekste Liezi列子 teigiama, jog žmogus turi modifikuoti savo suvokimo gebėjimus, kad suvienytų visą savo shen 神 („sielą“) ir taptų zhi ren 至人 („tobulu žmogumi“), galinčiu užmegzti ryšį su pirmapradėmis kosminėmis jėgomis ir įgyti ypatingų galių ir savybių. Mintis, kad tinkamas suvokimo suderinimas veda į šį būvį, yra giliai įsišaknijusi Liezi požiūryje į kosminės ir visuomeninės tvarkos evoliuciją. Čia aprašomas laipsniškas suvokimo proceso modifikavimas, leidžiantis jį sugretinti su pirmame skyriuje išdėstyta kosmogonija. Taigi, straipsnio tikslas yra išanalizuoti šiuos procesus, paaiškinti, kaip jie susiję tarpusavyje, ir ištirti, ką reiškia tapti „tobulu žmogumi“. Galiausiai paaiškėja, kad tik visiška suvokimo, įskaitant pagrindinio veikiančiojo – xin 心 („širdies”), užmarštis leidžia „tobulam žmogui“ tapti vieniu su pirmapradėmis jėgomis ir įgyti jų galią.
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7

Ying, Luo. "Cultural Values In The Novel “The Legend Of Condor Heroes” (Shen Diao Xia Lü) From Jin Yong." IJLECR - INTERNATIONAL JOURNAL OF LANGUAGE EDUCATION AND CULTURE REVIEW 2, no. 1 (June 6, 2016): 52–63. http://dx.doi.org/10.21009/ijlecr.021.06.

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The purpose of this research is to understand deeply about cultural values in the novel “The legend of Condor Heroes” from Jin Yong. This research uses qualitative method with structural semiotic approach. The results of this research showed the theme from this novel was about love, plot were progressive and dramatic, setting was in Dynasty of Zhong, and the point of view used third person. There were also found cultural values from semiotic aspects from Icon, indeks, and symbol they were independent, zhi (wise), control of emotion, Li (morality), Lian (pure heart), Ren (affection), Zhong (loyal), simplicity, Xiao (obedient), interflow with nature, accomplishing character, Yi (responsibility), praying, and obey rules of Budha.
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8

Hung, I.-Ling, Yu-Chiang Hung, Lin-Yi Wang, Sheng-Feng Hsu, Hsuan-Ju Chen, Ying-Jung Tseng, Chun-En Kuo, Wen-Long Hu, and Tsai-Chung Li. "Chinese Herbal Products for Ischemic Stroke." American Journal of Chinese Medicine 43, no. 07 (January 2015): 1365–79. http://dx.doi.org/10.1142/s0192415x15500779.

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Traditional Chinese herbal products (CHPs) have been described in ancient medicine systems as treatments for various stroke-associated ailments. This study is aimed to investigate the prescription patterns and combinations of CHPs for ischemic stroke in Taiwan. Prescriptions of CHPs for ischemic stroke were obtained from the National Health Insurance Research Database (NHIRD) of Taiwan. Every prescription with a leading diagnosis of ischemic stroke made during 2000–2010 was analyzed. Descriptive statistics were applied to the pattern of co-prescriptions. Multiple logistic regression models were used to assess demographic and risk factors that are correlated with CHP use. The dataset of inpatient claims data contained information on 15,896 subjects who experienced ischemic stroke from 2000 to 2010. There was an average of 5.82 CHPs in a single prescription for subjects with ischemic stroke. Bu-yang-huan-wu-tang (BYHWT) (40.32%) was by far the most frequently prescribed formula CHP for ischemic stroke, and the most commonly used combination of two-formula-CHP was BYHWT with Shu-jin-huo-xue-tang (SJHXT) (4.40%). Dan Shen (16.50%) was the most commonly used single CHP for ischemic stroke, and the most commonly used combination of two single CHPs was Shi Chang Pua with Yuan Zhi (4.79%). We found that BYHWT and Dan Shen were the most frequently prescribed formula and single CHP for ischemic stroke, respectively. These results provide information about individualized therapy and may contribute to further pharmacologic experiments and clinical trials.
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Pan, Weidong, Shin Kwak, Yun Liu, Yan Sun, Zhenglong Fang, Baofeng Qin, and Yoshiharu Yamamoto. "Traditional Chinese Medicine Improves Activities of Daily Living in Parkinson's Disease." Parkinson's Disease 2011 (2011): 1–7. http://dx.doi.org/10.4061/2011/789506.

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We evaluated the effects of a traditional Chinese medicine (TCM), named Zeng-xiao An-shen Zhi-chan 2 (ZAZ2), on patients with Parkinson's disease (PD). Among 115 patients with idiopathic PD enrolled (mean age, 64.7 ± 10.2 years old), 110 patients (M = 65, F = 45; mean age, 64.9 ± 10.7 years old) completed the study. Patients took either ZAZ2 () or placebo granule () in a blind manner for 13 weeks while maintaining other anti-Parkinson medications unchanged. All participants wore a motion logger, and we analyzed the power-law temporal autocorrelation of the motion logger records taken on 3 occasions (before, one week, and 13 weeks after the drug administration). Drug efficacy was evaluated with the conventional Unified Parkinson Disease Rating Scale (UPDRS), as well as the power-law exponentα, which corresponds to the level of physical activity of the patients. ZAZ2 but not placebo granule improved the awake-sleep rhythm, the UPDRS Part II, Part II + III, and Part IV scores, and theαvalues. The results indicate that ZAZ2 improved activities of daily living (ADL) of parkinsonism and, thus, is a potentially suitable drug for long-term use.
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이은영. "A Study on the Influence of Lie-Guo-Zhi-Zhuan(列國志傳) and Feng-Shen-Yan-Yi (封神演義)." Journal of the research of chinese novels ll, no. 26 (September 2007): 213–31. http://dx.doi.org/10.17004/jrcn.2007..26.013.

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이재홍. "A Study on the Influence of Lie-Guo-Zhi-Zhuan(列國志傳) and Feng-Shen-Yan-Yi (封神演義)." Journal of the research of chinese novels ll, no. 26 (September 2007): 233–70. http://dx.doi.org/10.17004/jrcn.2007..26.014.

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12

Chen, Chao, Yuan Hu, Xian-zhe Dong, Xiao-jiang Zhou, Li-hua Mu, and Ping Liu. "Proteomic Analysis of the Antidepressant Effects of Shen–Zhi–Ling in Depressed Patients: Identification of Proteins Associated with Platelet Activation and Lipid Metabolism." Cellular and Molecular Neurobiology 38, no. 5 (March 21, 2018): 1123–35. http://dx.doi.org/10.1007/s10571-018-0582-9.

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Huang, Chung-Yu, Yueh-Ting Tsai, Jung-Nien Lai, and Feng-Lin Hsu. "Prescription Pattern of Chinese Herbal Products for Diabetes Mellitus in Taiwan: A Population-Based Study." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/201329.

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Background.Traditional Chinese medicine (TCM), when given as a therapy for symptom relief, has gained widespread popularity among diabetic patients. The aim of this study is to analyze the utilization of TCM among type 2 diabetic patients in Taiwan.Methods.The use of TCM for type 2 diabetic patients were evaluated using a randomly sampled cohort of 1,000,000 beneficiaries recruited from the National Health Insurance Research Database.Results.Overall, 77.9%(n=31,289)of type 2 diabetic patients utilized TCM and 13.9%(n=4,351)of them used TCM for the treatment of type 2 diabetes. Among the top ten most frequently prescribed herbal formulae, four remedies,Zhi-Bo-Di-Huang-Wan, Qi-Ju-Di-Huang-Wan, Ji-Sheng-Shen-Qi-WanandBa-Wei-Di-Huang-Wanare derivative formulae ofLiu-Wei-Di-Huang-Wan.In other words,Liu-Wei-Di-Huang-Wanand its derivatives were found to be the most common herbal formulae prescribed by TCM doctors for the treatment of diabetes in Taiwan.Conclusion.Although some evidence does support the use TCM to treat diabetes, the results from the current study may have been confounded by placebo effect, which emphasize the need for well conducted, double-blind, randomized, placebo-controlled studies in order to further evaluate the efficacy ofLiu-Wei-Di-Huang-Wanon patients with type 2 diabetes.
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Yeung, Wing-Fai, Ka-Fai Chung, Maggie Man-Ki Poon, Fiona Yan-Yee Ho, Shi-Ping Zhang, Zhang-Jin Zhang, Eric Tat-Chi Ziea, and Vivian Wong Taam. "Prescription of Chinese Herbal Medicine and Selection of Acupoints in Pattern-Based Traditional Chinese Medicine Treatment for Insomnia: A Systematic Review." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–16. http://dx.doi.org/10.1155/2012/902578.

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Traditional Chinese medicine (TCM) treatments are often prescribed based on individuals' pattern diagnoses. A systematic review of Chinese and English literatures on TCM pattern differentiation, treatment principle, and pattern-based treatment for insomnia has therefore been conducted. A total of 227 studies, 17916 subjects, and 87 TCM patterns were analyzed. There was a limited consistency in pattern-based TCM treatment of insomnia across practitioners. Except for Gui Pi Tang, An Shen Ding Zhi Wan, and Wen Dan Tang which were used more commonly fordeficiency of both the heart and spleen,internal disturbance of phlegm-heat, andqi deficiency of the heart and gallbladder, respectively, the selection of herbal formula for other patterns and pattern-based prescription of individual herbs and acupoints were not consistent. Suanzaoren (Semen Z. spinosae), Fuling (Poria), Yejiaoteng (Caulis P. multiflori), Gancao (Radix Glycyrrhizae), Baishao (Radix P. alba), Shenmen (HT7), Yintang (EX-HN3), Sanyinjiao (SP6), Baihui (GV20), Anmian (EX-HN22), and Sishencong (EX-HN1) were commonly used, but nonspecifically for many patterns. Treatment principles underlying herb and acupoint selection were seldom reported. Although many studies were reviewed, the study quality and diagnostic process were inadequate. More high quality studies are needed to examine the additional benefits of pattern differentiation and pattern-based TCM treatment.
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Takano, Fumihide, Yasuyuki Ohta, Tomoaki Tanaka, Kenroh Sasaki, Kyoko Kobayashi, Tomoya Takahashi, Nobuo Yahagi, Fumihiko Yoshizaki, Shinji Fushiya, and Tomihisa Ohta. "Oral Administration of Ren-Shen-Yang-Rong-Tang ‘Ninjin’yoeito’ Protects against Hematotoxicity and Induces Immature Erythroid Progenitor Cells in 5-Fluorouracil-Induced Anemia." Evidence-Based Complementary and Alternative Medicine 6, no. 2 (2009): 247–56. http://dx.doi.org/10.1093/ecam/nem080.

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The purpose of this study was to investigate the efficacy of four different Japanese and Chinese herbal prescriptions, Ren-Shen-Yang-Rong-Tang (Ninjin’yoeito, NYT), Chai-Hu-Gui-Zhi-Gan-Jiang-Tang (Saikokeishikankyoto, SKKT), Si-Jun-Zi-Tang (Shikunshito, SKT) and Si-Wu-Tang (Shimotsuto, SMT), which are traditionally used for anemia and fatigue, against hematotoxicity in mice treated with 5-fluorouracil (5-FU). NYT 1–100 mg kg–1day–1injected orally for 7 consecutive days before and after 5-FU injection significantly suppressed reductions in red blood cell, white blood cell and platelet counts in peripheral blood, and accelerated their recovery. Administration of SKKT also produced a slight but significant improvement in 5-FU-induced erythrocytopenia, whereas SMT and SKT could not prevent anemia. Oral injection of NYT also inhibited 5-FU-induced decreases in peripheral reticulocyte and bone marrow cell counts on day 10, and markedly hastened their recovery on day 20, in a dose-dependent manner. Erythroid progenitor colonies, such as colony forming units-erythroid and burst forming units-erythroid, formed by marrow cells from mice treated with 5-FU were significantly increased by oral administration of NYT. These findings suggest that NYT has the potential to protect against hematotoxicity, and also has hematopoietic activity, through stimulation of immature erythroid progenitor cell differentiation.
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Xing, Sanli, Dingzhu Shen, Chuan Chen, Beiling Wu, and Huiying Chi. "Effect of the herbal formulation Shen-Zhi-Ling on an APP/PS1 mouse model of Alzheimer's disease by modulating the biliverdin reductase/heme oxygenase 1 system." Experimental and Therapeutic Medicine 14, no. 3 (July 9, 2017): 1961–66. http://dx.doi.org/10.3892/etm.2017.4732.

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Cevik, Abdulkadir. "Discussion on “Correction of soil parameters in calculation of embankment settlement using a BP network back-analysis model” By Zhi-liang Wang, Yong-chi Li, R.F. Shen [Engineering Geology 91 (2007) 168–177]." Engineering Geology 100, no. 3-4 (September 2008): 146–47. http://dx.doi.org/10.1016/j.enggeo.2008.03.005.

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Tseng, Chu-Yao, Ching-Wen Huang, Hsin-Chia Huang, and Wei-Chen Tseng. "Utilization Pattern of Traditional Chinese Medicine among Fracture Patients: A Taiwan Hospital-Based Cross-Sectional Study." Evidence-Based Complementary and Alternative Medicine 2018 (September 30, 2018): 1–9. http://dx.doi.org/10.1155/2018/1706517.

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Traditional Chinese medicine (TCM) divides fracture treatment into three stages. Many TCM herbs and formulas have been used to treat fractures for thousands of years. However, research regarding the Chinese herbal products (CHPs) that should be used at different periods of treatment is still lacking. This study aims to identify the CHPs that should be used at different periods of treatment as well as confirm the TCM theory of fracture periods medicine. We used prescriptions of TCM outpatients with fracture diagnoses analyzed using the Chang Gung Research Database (CGRD) from 2000 to 2015. According to the number of days between the date of the fracture and the clinic visit date, all patients were assigned to one of three groups. Patients with a date gap of 0-13 days were assigned to the early period group; those with a date gap of 14-82 days were assigned to the middle period group; and those with a date gap of 83-182 days were assigned to the late period group. We observed the average number of herbal formulas prescribed by the TCM doctor at each visit was 2.78, and the average number of single herbs prescribed was 6.47. The top three prescriptions in the early fracture period were Zheng-gu-zi-jin-dang, Shu-jing-huo-xue-tang, and Wu-ling-san. In the middle fracture period, the top three formulas were Zheng-gu-zi-jin-dang, Shu-jing-huo-xue-tang, and Zhi-bai-di-huang-wan. In the late fracture period, the top three formulas were Shu-jing-huo-xue-tang, Gui-lu-er-xian-jiao, and Du-huo-ji-sheng-tang. The main single herbs used in the early fracture period were Yan-hu-suo, Gu-sui-bu, and Dan-shen. From the middle to the late period, the most prescribed single herbs were Xu-duan, Gu-sui-bu, and Yan-hu-suo. We concluded that the results showed that the CGRD utilization pattern roughly meets the TCM theory at different fracture periods.
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LIU, Junxiang, and Guanhui WANG. "儒家思想與健康概念." International Journal of Chinese & Comparative Philosophy of Medicine 8, no. 2 (January 1, 2010): 73–85. http://dx.doi.org/10.24112/ijccpm.81493.

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LANGUAGE NOTE | Document text in Chinese; abstract also in English.健康是醫學哲學中最基本的概念之一。不少人認為，健康概念如同疾病一樣，受到不同價值觀念的影響，其內涵是多元化的，存在多種健康概念。筆者認為，我們所講的健康主要指人的健康，對健康的理解應當與對人的理解與界定聯繫起來。儘管不同哲學文化、思想觀念對人的界定各有側重，但都有共同的方面，健康概念也是如此。筆者認為， 世界衞生組織[World HealthOrganization (WHO)]的健康概念比較全面地揭示了健康的本質，已成為大多數人追求的健康目標。儒家對健康的理解主要基於人的道德意識和道德價值，強調修身養心、精神健康對維護軀體健康、構建和諧人際關係、社會環境的重要性，這與WHO 的定義有異曲同工之處。考察儒家思想對健康的理解，不僅有助於我們推進個體及人類健康，同時也有助於我們在價值多元化的後現代潮流中，為探尋不同民族文化、歷史傳統等之間的共同點提供思想基礎和實踐的可能性。Health is one of the basic concepts in the philosophy of medicine. Some philosophers hold that just as there are different concepts of diseases, there are different concepts of health, because such concepts are deeply influenced by value judgments. This papershows that health as we often talk about is the health of individual human beings, and that the concept of health should be based on an understanding of the essence of individual human beings. From this viewpoint, there is some common ground among the different concepts of health.The key issue discussed in this paper is what Confucian philosophy can contribute to the understanding and promotion of human health. Confucian philosophy claims that the essence of individual human beings lies in the virtues that distinguish human beings from animals. The main Confucian virtues are “ren,” “yi,” “li,” and “zhi” “Ren” means showing love to others, which is the core virtue and principle of perfecting oneself and having proper relationship with others. It emphasizes that personal mental health, good relationships with others, and a harmonious society are important factors of personal health. This paper argues that this Confucian viewpoint is closely aligned with the World Health Organization’s definition of health, and addresses the following relevant issues.1. In Confucian philosophy, “shen” (usually translated as “body”) has three meanings, referring not only to the physical body, but also to the unity of body and mind, and sometimes also to virtue. “Xin” mainly refers to the mind, but also refers tomoral consciousness.The holistic unity of body and mind urges people to pay attention to everyday life, especially diet, nutrition, and sleep. Mind is not another entity, but is embodied in the body.2. Confucian philosophy emphasizes that “xin” (mind) dominates “body.” It urges us to pay more attention to “xiu shen,” or perfecting ourselves. Emotions deeply influence health. In Confucian philosophy the “seven main emotions” are “love, anger, grief, joy, sadness, fear, and shock.” If these emotions are excessive, then they will cause illness and disease. Virtue can cultivate our character and help us to regulate these emotions correctly. Those who have virtue are always peaceful and long-lived. “Xiu shen” involves trying to be a “junzi,” or one who has moral virtue.3. Confucian philosophy emphasizes “xiu shen” and the individual’s obligation to personal behavior and health. Although the social environment and life conditions influence personal behavior and health, we are also responsible for our bhavior and health. A “junzi” is a kind of man who can persist with his virtue and resist lures. Medical knowledge and technology cannot cure all diseases, so everyone should take preventative measures.However, this does not mean that health is the result of virtue, or that disease is the result of immorality. Virtue is a necessary but not a sufficient condition for health. “It is a misfortune to lose health, but not misconduct.”4. Confucian health emphasizes that “xiu shen” and good interpersonal relationships are important to personal health. The core meaning of “ren” is to love and help others: what you do not want to be done to yourself, do not do to others. This principle helps one to get along well with family members, neighbors, and friends, and to construct ordered, harmonious interpersonal relationships and a favorable social environment. This benefits personal health and the welfare of human beings as a whole.In brief, Confucian philosophy promotes health, and helps people to live a happy life by developing perfect virtue. It is worth sharing with other nations.DOWNLOAD HISTORY | This article has been downloaded 768 times in Digital Commons before migrating into this platform.
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Xu, Rui, Qinghe Zeng, Chenjie Xia, Jiali Chen, Pinger Wang, Shan Zhao, Wenhua Yuan, et al. "Fractions of Shen-Sui-Tong-Zhi Formula Enhance Osteogenesis Via Activation of β-Catenin Signaling in Growth Plate Chondrocytes." Frontiers in Pharmacology 12 (September 24, 2021). http://dx.doi.org/10.3389/fphar.2021.711004.

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Background: Shen-sui-tong-zhi formula (SSTZF) has been used to treat osteoporosis for decades and shows excellent clinical efficacy. This article aims to explore the optimal anti-osteoporotic ingredient and its precise mechanisms in mice models.Methods: In this study, we first screened the optimal anti-osteoporosis fraction of SSTZF extract in vivo, and then further explored the mechanism of its effects both in vivo and in vitro. Ten-week-old female C57BL/6J mice were administrated with each fraction of SSTZF. At 10 weeks after ovariectomy (OVX), femurs were collected for tissue analyses, including histology, micro-CT, biomechanical tests, and immunohistochemistry for ALP, FABP4, and β-catenin. Additionally, we also evaluated the mRNA expression level of ALP and FABP4 and the protein expression level of β-catenin after being treated with SSTZF extract in C3H10T1/2 cells. Moreover, we investigated the anti-osteoporosis effect of SSTZF extract on mice with β-catenin conditional knockout in growth plate chondrocytes (β-cateninGli1ER mice) through μCT, histology, and immunohistochemistry analyzes.Results: At 10 weeks after treatment, osteoporosis-like phenotype were significantly ameliorated in SSTZF n-butanol extract (SSTZF-NB) group mice, as indicated by increased trabecular bone area and ALP content, and decreased lipid droplet area and FABP4 content. No such improvements were observed after being treated with other extracts, demonstrating that SSTZF-NB is the optimal anti-osteoporosis fraction. Additionally, the elevated β-catenin was revealed in both OVX mice and C3H10T1/2 cells with SSTZF-NB administered. Furthermore, a significant osteoporosis-like phenotype was observed in β-cateninGli1ER mice as expected. However, SSTZF-NB failed to rescue the deterioration in β-cateninGli1ER mice, no significant re-upregulated ALP and downregulated FABP4 were observed after being treated with SSTZF-NB, demonstrating that SSTZF-NB prevents bone loss mainly via β-catenin signaling.Conclusion: SSTZF-NB enhances osteogenesis mainly via activation of β-catenin signaling in growth plate chondrocytes. SSTZF-NB is the optimal anti-osteoporosis fraction of SSTZF and it can be considered a salutary alternative therapeutic option for osteoporosis.
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Song, Yuchen, Haixia Yuan, Tianyi Chen, Manqi Lu, Shuang Lei, and Xinmin Han. "An Shen Ding Zhi Ling Alleviates Symptoms of Attention Deficit Hyperactivity Disorder via Anti-Inflammatory Effects in Spontaneous Hypertensive Rats." Frontiers in Pharmacology 11 (January 18, 2021). http://dx.doi.org/10.3389/fphar.2020.617581.

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Attention deficit hyperactivity disorder (ADHD) is a childhood-onset chronic neurobehavioral disorder, with multiple genetic and environmental risk factors. Chronic inflammation may be critical for the progression of ADHD. An Shen Ding Zhi Ling (ASDZL) decoction, a traditional Chinese medicine prescription, is clinically used in ADHD treatment. In this study, we investigated the effects and underlying anti-inflammatory mechanisms of ASDZL in young spontaneously hypertensive rats (SHRs), a widely used model of ADHD. SHRs were divided into the SHR model group (vehicle), atomoxetine group (4.56 mg/kg/day) and ASDZL group (21.25 g/kg/day), and orally administered for four weeks. Wistar Kyoto rats were used as controls (vehicle). We found that ASDZL significantly controlled hyperactivity and impulsivity, and improved spatial memory of SHRs in the open field test and Morris water maze test. ASDZL reduced the pro-inflammatory factors interleukin (IL)-1β, IL-4, IL-6, tumor necrosis factor (TNF)-α and monocyte chemoattractant protein (MCP)-1 and increased anti-inflammatory factor IL-10 in SHRs, and decreased the activation of microglia, astrocytes and mast cells in the prefrontal cortex (PFC) and hippocampus. Furthermore, the results indicated that ASDZL inhibited the neuroinflammatory response by protecting the integrity of the blood-brain barrier and suppressing the mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-κB signaling pathways of SHRs. In conclusion, these findings revealed that ASDZL attenuated ADHD symptoms in SHRs by reducing neuroinflammation.
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Yue, Shengnan, Ting He, Baiyang Li, Yanqin Qu, Hongmei Peng, Jinxin Chen, Ming Lei, Chongli Chen, and Wenbin Wu. "Effectiveness of Yi-Zhi-An-Shen granules on cognition and sleep quality in older adults with amnestic mild cognitive impairment: protocol for a randomized, double-blind, placebo-controlled trial." Trials 20, no. 1 (August 20, 2019). http://dx.doi.org/10.1186/s13063-019-3607-x.

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Wang, Chen-Yu, Tang-Chuan Wang, Wen-Miin Liang, Chien-Hui Hung, Jian-Shiun Chiou, Chao-Jung Chen, Fuu-Jen Tsai, et al. "Effect of Chinese Herbal Medicine Therapy on Overall and Cancer Related Mortality in Patients With Advanced Nasopharyngeal Carcinoma in Taiwan." Frontiers in Pharmacology 11 (January 29, 2021). http://dx.doi.org/10.3389/fphar.2020.607413.

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Nasopharyngeal carcinoma (NPC) is a head and neck cancer involving epithelial squamous-cell carcinoma of the nasopharynx that mainly occurs in individuals from East and Southeast Asia. We investigated whether Chinese herbal medicine (CHM) as a complementary therapy offers benefits to these patients. We retrospectively evaluated the Taiwan Cancer Registry (Long Form) database for patients with advanced NPC, using or not using CHM, between 2007–2013. Cox proportional-hazard model and Kaplan‒Meier survival analyses were applied for patient survival. CHM-users showed a lower overall and cancer-related mortality risk than non-users. For advanced NPC patients, the overall mortality risk was 0.799-fold for CHM-users, after controlling for age, gender, and Charlson comorbidity index (CCI) score (Cancer stages 3 + 4: adjusted hazard ratio [aHR]: 0.799, 95% confidence interval [CI]: 0.676–0.943, p = 0.008). CHM-users also showed a lower cancer-related mortality risk than non-users (aHR: 0.71, 95% CI: 0.53–0.96, p = 0.0273). Association rule analysis showed that CHM pairs were Ban-Zhi-Lian (BZL; Scutellaria barbata D.Don) and For single herbs, Bai-Hua-She-She-Cao (Herba Hedyotis Diffusae; Scleromitrion diffusum (Willd.) R.J.Wang (syn. Hedyotis diffusa Willd.) and Mai-Men-Dong (MMD; Ophiopogon japonicus (Thunb.) Ker Gawl.), and Gan-Lu-Yin (GLY) and BHSSC. Network analysis revealed that BHSSC was the core CHM, and BZL, GLY, and Xin-Yi-Qing-Fei-Tang (XYQFT) were important CHMs in cluster 1. In cluster 2, ShengDH, MMD, Xuan-Shen (XS; Scrophularia ningpoensis Hensl.), and Gua-Lou-Gen (GLG; Trichosanthes kirilowii Maxim.) were important CHMs. Thus, as a complementary therapy, CHM, and particularly the 8 CHMs identified, are important for the treatment of advanced NPC patients.
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Araújo-Júnior, Júlio Leite de, Elma Mariana Verçosa de Melo-Silva, Anderson Maikon de Souza-Santos, Tiburtino José de Lima-Neto, Murilo Quintão dos Santos, and Eduardo Dias-Ribeiro. "Tratamento de fratura nasal pediátrica: relato de caso clínico." ARCHIVES OF HEALTH INVESTIGATION 7, no. 12 (March 20, 2019). http://dx.doi.org/10.21270/archi.v7i12.3056.

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Introdução: Os ossos nasais são os mais proeminentes do esqueleto facial, tornando esses os mais frequentes nas fraturas faciais, sendo o terceiro osso mais comumente fraturado do esqueleto humano. Objetivo: Apresentar um relato de caso de fratura nasal em um paciente pediatrico tratado com redução incruenta. Método: Estudo descritivo com um paciente que apresentou diagnóstico clínico/imaginológico de fratura nasal. Conclusão: O tratamento através de redução incluenta mostrou-se adequado em pacientes pediatricos. A ocorrência de traumatismos e lesões associadas a fraturas nasais reforça a importância de uma abordagem multidisciplinar.Descritores: Fraturas Ósseas; Osso Nasal; Traumatismos Faciais.ReferênciasMa L, Shen SH, Hu P, Wu ZQ. The observation of curative effect on closed reduction of nasal bone fracture under ultrasound guidance: report of 38 cases. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017;52(12):933-35.Schoinohoriti O, Igoumenakis D, Rallis G. Fractures of the nasal bones: is external splinting really warranted? J Craniofac Surg. 2017;28(8):e760-e63.Kang CM, Han DG. Correlation between Operation Result and Patient Satisfaction of Nasal Bone Fracture. Arch Craniofac Surg. 2017;18(1):25-9.Kyung H, Choi JI, Song SH, Oh SH, Kang N. Comparison of postoperative outcomes between monitored anesthesia care and general anesthesia in closed reduction of nasal fracture. J Craniofac Surg. 2018;29(2):286-88.Nishioka H, Kondoh S, Yuzuriha S. Convex bone deformity after closed reduction of nasal bone fracture. J Plast Reconstr Aesthet Surg. 2018;71(1):85-9.Lu GN, Humphrey CD, Kriet JD. Correction of Nasal Fractures. Facial Plast Surg Clin North Am. 2017;25(4):537-546.Kim SW, Park B, Lee TG, Kim JY. Olfactory Dysfunction in Nasal Bone Fracture. Arch Craniofac Surg. 2017;18(2):92-6.Davidson J, Nickerson D, Nickerson B. Zygomatic fractures: comparison of methods of internal fixation. Plast Reconstr Surg. 1990;86(1):25-32.Yabe T, Tsuda T, Hirose S, Ozawa T. Comparison of pediatric and adult nasal fractures. J Craniofac Surg. 2012;23(5):1364-6.Murphy RX Jr, Birmingham KL, Okunski WJ, Wasser TE. Influence of restraining devices on patterns of pediatric facial trauma in motor vehicle collisions. Plast Reconstr Surg. 2001;107(1):34-7.
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"Corrigendum: Water Science and Technology70 (10), 1663–1669: Adsorption and removal of triphenylmethane dyes from water by magnetic reduced graphene oxide, Jian-Zhong Sun, Zhi-Hong Liao, Rong-Wei Si, Gakai Peter Kingori, Fu-Xiang Chang, Lu Gao, Yu Shen, Xiang Xiao, Xiang-Yang Wu and Yang-Chun Yong." Water Science and Technology 71, no. 6 (March 1, 2015): 955. http://dx.doi.org/10.2166/wst.2015.063.

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