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Relevant bibliographies by topics / Penicillin biosynthesis

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Academic literature on the topic 'Penicillin biosynthesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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Journal articles on the topic "Penicillin biosynthesis"

1

Baldwin, Jack E., Edward P. Abraham, Geoffrey L. Burge, and Hong-Hoi Ting. "Penicillin biosynthesis: direct biosynthetic formation of penicillin V and penicillin G." Journal of the Chemical Society, Chemical Communications, no. 24 (1985): 1808. http://dx.doi.org/10.1039/c39850001808.

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Spröte, Petra, Axel A. Brakhage, and Michael J. Hynes. "Contribution of Peroxisomes to Penicillin Biosynthesis in Aspergillus nidulans." Eukaryotic Cell 8, no. 3 (2009): 421–23. http://dx.doi.org/10.1128/ec.00374-08.

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ABSTRACT Peroxisomal localization of the third enzyme of the penicillin biosynthesis pathway of Aspergillus nidulans, acyl-coenzyme A:IPN acyltransferase (IAT), is mediated by its atypical peroxisomal targeting signal 1 (PTS1). However, mislocalization of IAT by deletion of either its PTS1 or of genes encoding proteins involved in peroxisome formation or transport does not completely abolish penicillin biosynthesis. This is in contrast to the effects of IAT mislocalization in Penicillium chrysogenum.

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Nijland, Jeroen G., Bjorg Ebbendorf, Marta Woszczynska, Rémon Boer, Roel A. L. Bovenberg, and Arnold J. M. Driessen. "Nonlinear Biosynthetic Gene Cluster Dose Effect on Penicillin Production by Penicillium chrysogenum." Applied and Environmental Microbiology 76, no. 21 (2010): 7109–15. http://dx.doi.org/10.1128/aem.01702-10.

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ABSTRACT Industrial penicillin production levels by the filamentous fungus Penicillium chrysogenum increased dramatically by classical strain improvement. High-yielding strains contain multiple copies of the penicillin biosynthetic gene cluster that encodes three key enzymes of the β-lactam biosynthetic pathway. We have analyzed the gene cluster dose effect on penicillin production using the high-yielding P. chrysogenum strain DS17690 that was cured from its native clusters. The amount of penicillin V produced increased with the penicillin biosynthetic gene cluster number but was saturated at

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4

KURZĄTKOWSKI, WIESŁAW, MONIKA STANISZEWSKA, MAŁGORZATA BONDARYK, and ANITA GĘBSKA-KUCZEROWSKA. "Compartmentalization in Penicillin G Biosynthesis by Penicillium chrysogenum PQ-96." Polish Journal of Microbiology 63, no. 4 (2014): 399–408. http://dx.doi.org/10.33073/pjm-2014-054.

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The arrangement of organelles in the sub-apical productive non-growing vacuolated hyphal cells of the high- and the low-penicillin-pro- ducing strains Penicillium chrysogenum was compared using transmission electron microscopy. In the productive cells of the high-yielding strain the endoplasmic reticulum and the polyribosomes with associated peroxisomes are frequently arranged at the periphery of the cytoplasm and around the vacuoles. At the high activity of penicillin G biosynthesis the immuno-label of the cytosolic isopenicillin N synthase is concentrated at the polyribosomes arranged in the

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5

Hajdu, Janos. "PENICILLIN AND CEPHALOSPORIN BIOSYNTHESIS." Biochemical Society Transactions 27, no. 1 (1999): A4. http://dx.doi.org/10.1042/bst027a004.

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6

Hoff, Birgit, Jens Kamerewerd, Claudia Sigl, et al. "Two Components of a velvet-Like Complex Control Hyphal Morphogenesis, Conidiophore Development, and Penicillin Biosynthesis in Penicillium chrysogenum." Eukaryotic Cell 9, no. 8 (2010): 1236–50. http://dx.doi.org/10.1128/ec.00077-10.

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ABSTRACT Penicillium chrysogenum is the industrial producer of the antibiotic penicillin, whose biosynthetic regulation is barely understood. Here, we provide a functional analysis of two major homologues of the velvet complex in P. chrysogenum, which we have named P. chrysogenum velA (PcvelA) and PclaeA. Data from array analysis using a ΔPcvelA deletion strain indicate a significant role of PcVelA on the expression of biosynthesis and developmental genes, including PclaeA. Northern hybridization and high-performance liquid chromatography quantifications of penicillin titers clearly show that

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7

Martín, Jorge, Carlos García-Estrada, Ángel Rumbero, et al. "Characterization of an Autoinducer of Penicillin Biosynthesis in Penicillium chrysogenum." Applied and Environmental Microbiology 77, no. 16 (2011): 5688–96. http://dx.doi.org/10.1128/aem.00059-11.

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ABSTRACTFilamentous fungi produce an impressive variety of secondary metabolites; many of them have important biological activities. The biosynthesis of these secondary metabolites is frequently induced by plant-derived external elicitors and appears to also be regulated by internal inducers, which may work in a way similar to that of bacterial autoinducers. The biosynthesis of penicillin inPenicillium chrysogenumis an excellent model for studying the molecular mechanisms of control of gene expression due to a good knowledge of the biochemistry and molecular genetics of β-lactam antibiotics an

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8

García-Estrada, Carlos, Ricardo V. Ullán, Tania Velasco-Conde, et al. "Post-translational enzyme modification by the phosphopantetheinyl transferase is required for lysine and penicillin biosynthesis but not for roquefortine or fatty acid formation in Penicillium chrysogenum." Biochemical Journal 415, no. 2 (2008): 317–24. http://dx.doi.org/10.1042/bj20080369.

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NRPSs (non-ribosomal peptide synthetases) and PKSs (polyketide synthases) require post-translational phosphopantetheinylation to become active. This reaction is catalysed by a PPTase (4′-phosphopantetheinyl transferase). The ppt gene of Penicillium chrysogenum, encoding a protein that shares 50% similarity with the stand-alone large PPTases, has been cloned. This gene is present as a single copy in the genome of the wild-type and high-penicillin-producing strains (containing multiple copies of the penicillin gene cluster). Amplification of the ppt gene produced increases in isopenicillin N and

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9

van de Kamp, Mart, Theo A. Schuurs, Arnold Vos, Ted R. van der Lende, Wil N. Konings, and Arnold J. M. Driessen. "Sulfur Regulation of the Sulfate Transporter GenessutA and sutB in Penicillium chrysogenum." Applied and Environmental Microbiology 66, no. 10 (2000): 4536–38. http://dx.doi.org/10.1128/aem.66.10.4536-4538.2000.

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ABSTRACT Penicillium chrysogenum uses sulfate as a source of sulfur for the biosynthesis of penicillin. Sulfate uptake and the mRNA levels of the sulfate transporter-encoding sutB andsutA genes are all reduced by high sulfate concentrations and are elevated by sulfate starvation. In a high-penicillin-yielding strain, sutB is effectively transcribed even in the presence of excess sulfate. This deregulation may facilitate the efficient incorporation of sulfur into cysteine and penicillin.

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10

Lu, Ying, Robert L. Mach, Karin Affenzeller та Christian P. Kubicek. "Regulation of α-aminoadipate reductase from Penicillium chrysogenum in relation to the flux from α-aminoadipate into penicillin biosynthesis". Canadian Journal of Microbiology 38, № 8 (1992): 758–63. http://dx.doi.org/10.1139/m92-123.

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The activity and regulation of α-aminoadipate reductase in three Penicillium chrysogenum strains (Q176, D6/1014/A, and P2), producing different amounts of penicillin, were studied. The enzyme exhibited decreasing affinity for α-aminoadipate with increasing capacity of the respective strain to produce penicillin. The enzyme from all three strains was inhibited by L-lysine, and the enzyme from the lowest producer, Q176, was least sensitive. Between pH 7.5 and 6.5, inhibition of α-aminoadipate reductase by L-lysine was pH dependent, being more pronounced at lower pH. The highest producer strain,

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Dissertations / Theses on the topic "Penicillin biosynthesis"

1

Smith, David John. "A genetic study of penicillin biosynthesis in Penicillium chrysogenum." Thesis, University of Bristol, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292440.

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Long, Alexandra. "Structural studies on penicillin biosynthesis." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393574.

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Porter, Michael James. "Mechanistic investigations into penicillin biosynthesis." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308806.

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4

Rowe, Christine Janet. "Genetic engineering of penicillin biosynthesis." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307008.

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Sutherland, John David. "Genetic engineering of penicillin biosynthesis." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253132.

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Martyres, Dominic H. "Bicyclic penicillin mimics." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365770.

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Shorrock, Celia Patricia. "Studies on penicillin and cephalosporin biosynthesis." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298666.

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8

Killin, S. J. "Studies on the biosynthesis of penicillin." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379964.

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9

Domayne-Hayman, B. P. "Penicillin biosynthesis : Mechanistic probes containing small rings." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379884.

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Moroney, S. E. "Kinetic studies on the biosynthesis of penicillin." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354849.

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Books on the topic "Penicillin biosynthesis"

1

Gaudet, Veronique Suzanne Blanche. Synthetic and enzymatic studies related to the biosynthesis of penicillic acid and acetoin. typescript, 1989.

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2

Penicillin: Biosynthesis, Applications and Adverse Effects. Nova Novinka, 2012.

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Book chapters on the topic "Penicillin biosynthesis"

1

Brakhage, Axel A., Petra Spröte, Qusai Al-Abdallah, Alexander Gehrke, Hans Plattner, and André Tüncher. "Regulation of Penicillin Biosynthesis in Filamentous Fungi." In Molecular Biotechnolgy of Fungal beta-Lactam Antibiotics and Related Peptide Synthetases. Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/b99257.

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2

Turner, G. "Genetics of Penicillin Biosynthesis in Aspergillus Nidulans." In The Genus Aspergillus. Springer US, 1994. http://dx.doi.org/10.1007/978-1-4899-0981-7_14.

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3

Turner, G., P. E. Browne, and A. A. Brakhage. "Expression of genes for the biosynthesis of penicillin." In Molecular Biology and its Application to Medical Mycology. Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-84625-0_15.

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4

Queener, S. W. "Molecular Biology of Penicillin and Cephalosporin Biosynthesis: Application of Cloned Genes." In Recent Advances in Biotechnology. Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2468-3_10.

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5

Bycroft, B. W., and R. E. Shute. "Chemistry and Biosynthesis of Penicillins and Cephalosporins." In Penicillium and Acremonium. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4899-1986-1_5.

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6

Kubicek, C. P., C. Hönlinger, W. M. Jaklitsch, et al. "Regulation of lysine biosynthesis in the fungus Penicillium chrysogenum." In Amino Acids. Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-011-2262-7_128.

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7

Färber, Paul, and Rolf Geisen. "Analysis of differentially-expressed ochratoxin A biosynthesis genes of Penicillium nordicum." In Molecular Diversity and PCR-detection of Toxigenic Fusarium Species and Ochratoxigenic Fungi. Springer Netherlands, 2004. http://dx.doi.org/10.1007/978-1-4020-2285-2_20.

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8

Geisen, Rolf, Markus Schmidt-Heydt, Dominic Stoll, and Najim Touhami. "Aspects of the Occurrence, Genetics, and Regulation of Biosynthesis of the Three Food Relevant Penicillium Mycotoxins: Ochratoxin A, Citrinin, and Patulin." In Physiology and Genetics. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-71740-1_14.

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9

"Penicillin Biosynthesis." In Physiological Engineering Aspects of Penicillium Chrysogenum. WORLD SCIENTIFIC, 1997. http://dx.doi.org/10.1142/9789812819987_0005.

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10

Martin, Juan F., Thomas D. Ingolia, and Stephen W. Queener. "Molecular Genetics of Penicillin and Cephalosporin Antibiotic Biosynthesis." In Molecular Industrial Mycology. Routledge, 2017. http://dx.doi.org/10.1201/9780203746554-7.

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Conference papers on the topic "Penicillin biosynthesis"

1

Erokhin, D. V., O. D. Mikityuk, L. A. Shcherbakova, and V. G. Dzhavakhiya. "Inhibition of the biosynthesis of polyketide mycotoxins by microbial metabolites." In 2nd International Scientific Conference "Plants and Microbes: the Future of Biotechnology". PLAMIC2020 Organizing committee, 2020. http://dx.doi.org/10.28983/plamic2020.065.

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6-Demethylmevinoliin, a secondary metabolite of Penicillum citrinum, is able to efficiently inhibit the biosynthesis of two polypeptide mycotoxins, aflatoxin B1 and zearalenone, by 92 and 78% of the control, respectively.

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"The Effect of Bifidobacterium Breve and Lactobacillus Salivarius on the Isoepoxydon Dehydrogenase (Idh) Gene Expression Involved in Patulin Biosynthesis Produced by Penicillium Expansum." In 2016 International Conference on Biological and Environmental Science. Universal Researchers, 2016. http://dx.doi.org/10.17758/ur.u0616207.

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