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Journal articles on the topic 'Penicillium'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Lalchhandama, Kholhring. "History of penicillin." WikiJournal of Medicine 8, no. 1 (2021): 3. http://dx.doi.org/10.15347/wjm/2021.003.

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The history of penicillin was shaped by the contributions of numerous scientists. The ultimate result was the discovery of the mould Penicillium's antibacterial activity and the subsequent development of penicillins, the most widely used antibiotics. Following an accidental discovery of the mould, later identified as Penicillium rubens, as the source of the antibacterial principle (1928) and the production of a pure compound (1942), penicillin became the first naturally derived antibiotic. There is anecdotal evidence of ancient societies using moulds to treat infections and of awareness that v

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2

Frisvad, J. C., O. Filtenborg, and D. T. Wicklow. "Terverticillate penicillia isolated from underground seed caches and cheek pouches of banner-tailed kangaroo rats (Dipodomys spectabilis)." Canadian Journal of Botany 65, no. 4 (1987): 765–73. http://dx.doi.org/10.1139/b87-102.

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Terverticillate penicillia were important colonists of the underground seed caches and the external cheek pouches of the banner-tailed kangaroo rat (Dipodomys spectabilis) from the North American desert. Two taxa representing the dominant Penicillium populations are described as new varieties of well-known ubiquitous species. Penicillium chrysogenum var. dipodomyis var.nov. produces the antibiotic penicillin but does not produce mycotoxins (PR-toxin and roquefortine C) known from P. chrysogenum. The new variety is further distinguished by having rough-walled stipes. Penicillium aurantiogriseum

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3

Frisvad, J. C. "A critical review of producers of small lactone mycotoxins: patulin, penicillic acid and moniliformin." World Mycotoxin Journal 11, no. 1 (2018): 73–100. http://dx.doi.org/10.3920/wmj2017.2294.

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A very large number of filamentous fungi has been reported to produce the small lactone mycotoxins patulin, penicillic acid and moniliformin. Among the 167 reported fungal producers of patulin, only production by 29 species could be confirmed. Patulin is produced by 3 Aspergillus species, 3 Paecilomyces species, 22 Penicillium species from 7 sections of Penicillium, and one Xylaria species. Among 101 reported producers of penicillic acid, 48 species could produce this mycotoxin. Penicillic acid is produced by 23 species in section Aspergillus subgenus Circumdati section Circumdati, by Malbranc

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4

Laich, Federico, Francisco Fierro, and Juan F. Martín. "Production of Penicillin by Fungi Growing on Food Products: Identification of a Complete Penicillin Gene Cluster in Penicillium griseofulvum and a Truncated Cluster in Penicillium verrucosum." Applied and Environmental Microbiology 68, no. 3 (2002): 1211–19. http://dx.doi.org/10.1128/aem.68.3.1211-1219.2002.

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ABSTRACT Mycobiota growing on food is often beneficial for the ripening and development of the specific flavor characteristics of the product, but it can also be harmful due to the production of undesirable compounds such as mycotoxins or antibiotics. Some of the fungi most frequently isolated from fermented and cured meat products such as Penicillium chrysogenum and Penicillium nalgiovense are known penicillin producers; the latter has been shown to be able to produce penicillin when growing on the surface of meat products and secrete it to the medium. The presence of penicillin in food must

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5

Bamigboye, O. O. "Screening of Some Fungi Associated with Maize Cob Degradation for Cellulase Activity." Greener Journal of Agricultural Sciences 3, no. 6 (2013): 492–96. https://doi.org/10.15580/GJAS.2013.6.011613389.

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Fungi involved in the biodegradation of maize- cob were isolated and screened for cellulase activity using glucose and carboxylmethyl cellulose as carbon sources.  The effect of the carbon sources on cellulase production was determined.  Eleven fungi species were isolated which include <em>Rhizopus oryzae, Aspergillus flavus,. Mucor racemosus, Aspergillus niger, Penicillium atrovenetum, Penicillium expansum, Botryotrichum piluliferum, Penicillium chrysogenum</em> and <em>Penicillium restictum</em>. Effect of carbon source on cellulase production was also repo

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Bamigboye, O. O. "Screening of Some Fungi Associated with Maize Cob Degradation for Cellulase Activity." Greener Journal of Biological Sciences 3, no. 6 (2013): 208–12. https://doi.org/10.15580/gjbs.2013.6.011613389.

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Fungi involved in the biodegradation of maize- cob were isolated and screened for cellulase activity using glucose and carboxylmethyl cellulose as carbon sources. The effect of the carbon sources on cellulase production was determined.  Eleven fungi species were isolated which include <em>Rhizopus oryzae, Aspergillus flavus, Mucor racemosus, Aspergillus niger, Penicillium atrovenetum, Penicillium expansum, Botryotrichum piluliferum, Penicillium chrysogenum</em> and<em> Penicillium restictum</em>. Effect of carbon source on cellulase production was also reported. The highest

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7

Hardianto, Dudi, Suyanto ., Erwahyuni Endang Prabandari, Lira Windriawati, Edy Marwanta, and Tarwadi . "PENICILLIN PRODUCTION BY MUTANT OF Penicillium chrysogenum." Jurnal Bioteknologi & Biosains Indonesia (JBBI) 2, no. 1 (2016): 15. http://dx.doi.org/10.29122/jbbi.v2i1.530.

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Penisilin adalah antibiotika yang pertama kali ditemukan dan digunakan untuk pengobatan infeksi bakteri. Sejak ditemukan penisilin sebagai antibiotika oleh Alexander Fleming pada tahun 1928, banyak usaha dilakukan untuk meningkatkan produktivitas Penicillium chrysogenum. Pemuliaan galur untuk meningkatkan produksi penisilin dapat menggunakan mutasi acak secara fisika dan kimia. Pada penelitian ini, radiasi sinar ultraviolet digunakan untuk mendapatkan mutan P. chrysogenum. Produksi penisilin ditentukan menggunakan HPLC dan produktivitas mutan dibandingkan dengan induk P. chrysogenum. Mutan M12

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8

Zafrin, Mehnaz, Shamim Shamsi, and Md Abdullah Al Noman. "Morpho-molecular charactrization of endophytic fungi associated with aquilaria malaccensis lam." Bangladesh Journal of Plant Taxonomy 31, no. 1 (2024): 141–54. http://dx.doi.org/10.3329/bjpt.v31i1.74394.

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A total of 26 fungal isolates were identified from Aquilaria malaccensis Lam. (Agarwood). Among them Aspergillus flavus Link type-1, Aspergillus flavus Link type-2, Aspergillus niger Tiegh. type. 1, Aspergillus niger Tiegh. type. 2, Aspergillus sp. 1, Aspergillus sp. 2, Alternaria alternata (Fr.) keissl., Curvularia lunata (Wakker) Boedijn, Penicillum digitatum (Pers.) Sacc., Penicillium commune Thom, Penicillum italicum Wehmer, Penicillium sp. 1, Penicillium sp. 2, Penicillium sp. 3, Penicillium sp. 4, Eupenicillium sp. 1, Eupenicillium sp. 2, Sphaeropsis sp. Sacc. and Harknessia sp. Cooke. w

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9

Houbraken, Jos, Carlos A. López-Quintero, Jens C. Frisvad, et al. "Penicillium araracuarense sp. nov., Penicillium elleniae sp. nov., Penicillium penarojense sp. nov., Penicillium vanderhammenii sp. nov. and Penicillium wotroi sp. nov., isolated from leaf litter." International Journal of Systematic and Evolutionary Microbiology 61, no. 6 (2011): 1462–75. http://dx.doi.org/10.1099/ijs.0.025098-0.

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Several species of the genus Penicillium were isolated during a survey of the mycobiota of leaf litter and soil in Colombian Amazon forest. Five species, Penicillium penarojense sp. nov. (type strain CBS 113178T = IBT 23262T), Penicillium wotroi sp. nov. (type strain CBS 118171T = IBT 23253T), Penicillium araracuarense sp. nov. (type strain CBS 113149T = IBT 23247T), Penicillium elleniae sp. nov. (type strain CBS 118135T = IBT 23229T) and Penicillium vanderhammenii sp. nov. (type strain CBS 126216T = IBT 23203T) are described here as novel species. Their taxonomic novelty was determined using

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10

Andersen, S. J., and J. C. Frisvad. "Penicillin production by Penicillium nalgiovense." Letters in Applied Microbiology 19, no. 6 (1994): 486–88. http://dx.doi.org/10.1111/j.1472-765x.1994.tb00988.x.

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11

Pitt, J. I. "Phylogeny in the genus Penicillium: a morphologist's perspective." Canadian Journal of Botany 73, S1 (1995): 768–77. http://dx.doi.org/10.1139/b95-321.

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Great advances have taken place in our understanding of the taxonomy of Penicillium and its teleomorphs in the past 15 years. Physiological and biochemical techniques, applied in conjunction with morphology, have enabled the taxonomy of this difficult genus to approach consensus. Such information, plus existing molecular data, have been used here to construct a hypothetical phylogeny. The proposed phylogeny is based on a number of postulates, including the following: (i) evolution has proceeded from holomorph to strict anamorph; (ii) an intermediate stage exists, the sclerotigenic anamorph; (i

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12

Frisvad, Jens C., Thomas O. Larsen, Petur W. Dalsgaard, et al. "Four psychrotolerant species with high chemical diversity consistently producing cycloaspeptide A, Penicillium jamesonlandense sp. nov., Penicillium ribium sp. nov., Penicillium soppii and Penicillium lanosum." International Journal of Systematic and Evolutionary Microbiology 56, no. 6 (2006): 1427–37. http://dx.doi.org/10.1099/ijs.0.64160-0.

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Penicillium jamesonlandense is a novel species from Greenland that grows exceptionally slowly at 25 °C and has an optimum temperature for growth of 17–18 °C. The novel species is more psychrotolerant than any other Penicillium species described to date. Isolates of this novel species produce a range of secondary metabolites with a high chemical diversity, represented by kojic acid, penicillic acid, griseofulvin, pseurotin, chrysogine, tryptoquivalins and cycloaspeptide. Penicillium ribium, another novel psychrotolerant species from the Rocky Mountains, Wyoming, USA, produces asperfuran, kojic

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13

Lewis, Jesse A., and Nadja Anderson. "Penicillium Antibiotic Effect." American Biology Teacher 80, no. 7 (2018): 530–35. http://dx.doi.org/10.1525/abt.2018.80.7.530.

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In this lesson students will use the Penicillium chrysogenum fungus, which naturally produces the antibiotic penicillin, to investigate the effect of naturally produced antibiotics on bacteria in laboratory cultures. Students co-culture P. chrysogenum with three species of bacteria to observe differences between penicillin-resistant and penicillin-sensitive bacteria. They will normalize fungal spore suspension and bacterial culture concentrations before inoculating co-cultures. After bacteria have been exposed to the antibiotic, students will quantify culture density to determine antibiotic ef

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14

Felšöciová, Soňa, and Miroslava Kačániová. "Mycotoxin-producing Penicillium spp. and other fungi isolated from grapes for wine production in Small Carpathians wine region." Potravinarstvo Slovak Journal of Food Sciences 13, no. 1 (2019): 194–99. http://dx.doi.org/10.5219/1044.

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The diversity of mycobiota associated with grapevine in Vrbove, Slovakia at the harvest time in 2018 was evaluated. Fourteen samples of grapes were analyzed by plating methods and by plating methods with surface disinfection. The identification of fungi was performed using the morphological and microscopical characteristics. From the 1001 strains detected and identified from exogenous mycobiota, the most frequent genera were Alternaria, Rhizopus and Sordaria. Their relative density was low, except Alternaria. The most frequently encountered moulds and with the highest relative density from end

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15

Komai, Shin-ichirou, Tomoo Hosoe, Takeshi Itabashi, et al. "New penicillide derivatives isolated from Penicillium simplicissimum." Journal of Natural Medicines 60, no. 3 (2006): 185–90. http://dx.doi.org/10.1007/s11418-005-0028-9.

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16

Debbarma, R., T. Prameeladevi, A. Tyagi, and D. Kamil. "Polyphasic taxonomic characterization of nine Penicillium species from soil of different parts of India." Journal of Environmental Biology 42, no. 5 (2021): 1307–13. http://dx.doi.org/10.22438/jeb/42/5/mrn-1590.

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Aim: Morpho-molecular analyses for taxonomic characterization of nine predominant Penicillium species present in the soil of different parts of India. Methodology: Fifteen Penicillium isolates were isolated from the soil samples collected from the experimental field of ICAR-Indian Agricultural Research Institute (IARI), New Delhi. Another twenty-six isolates were procured from Indian Type Culture Collection (ITCC), Division of Plant Pathology, ICAR-IARI, New Delhi which were isolated from the soil of different parts of India. Total 41 isolates were characterized following distinct macroscopic

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17

Laich, Federico, Francisco Fierro, Rosa Elena Cardoza, and Juan F. Martin. "Organization of the Gene Cluster for Biosynthesis of Penicillin in Penicillium nalgiovense and Antibiotic Production in Cured Dry Sausages." Applied and Environmental Microbiology 65, no. 3 (1999): 1236–40. http://dx.doi.org/10.1128/aem.65.3.1236-1240.1999.

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ABSTRACT Several fungal isolates obtained from two cured meat products from Spain were identified as Penicillium nalgiovense by their morphological features and by DNA fingerprinting. All P. nalgiovense isolates showed antibiotic activity in agar diffusion assays, and their penicillin production in liquid complex medium ranged from 6 to 38 μg · ml−1. We constructed a restriction map of the penicillin gene cluster of P. nalgiovense and found that the organization of the penicillin biosynthetic genes (pcbAB, pcbC, andpenDE) is the same as in Penicillium chrysogenum and Aspergillus nidulans. Thep

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18

NÚÑEZ, FÉLIX, CARMEN D. WESTPHAL, ELENA BERMÚDEZ, and MIGUEL A. ASENSIO. "Production of Secondary Metabolites by Some Terverticillate Penicillia on Carbohydrate-Rich and Meat Substrates." Journal of Food Protection 70, no. 12 (2007): 2829–36. http://dx.doi.org/10.4315/0362-028x-70.12.2829.

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Most terverticillate penicillia isolated from dry-cured meat products are toxigenic, but their ability to produce hazardous metabolites on meat-based substrates is not well known. The production of extrolites by selected terverticillate penicillia isolated from dry-cured ham has been studied on carbohydrate-rich media (malt extract agar, Czapek yeast autolysate agar, rice extract agar, and rice), meat extract triolein salt agar, and ham slices. Chloroform extracts from the selected strains grown on malt extract agar were toxic for the brine shrimp (Artemia salina) larvae and VERO cells at a co

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19

Petersson, Stina, and Johan Schnürer. "Pichia anomalaas a biocontrol agent ofPenicillium roquefortiin high-moisture wheat, rye, barley, and oats stored under airtight conditions." Canadian Journal of Microbiology 44, no. 5 (1998): 471–76. http://dx.doi.org/10.1139/w98-018.

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Pichia anomala inhibits growth of Penicillium roqueforti in high-moisture winter wheat, barley, and oats in cases where a malfunctioning airtight feed-storage system allows air to leak in. To imitate air leakage to such a storage system, grain was inoculated, packed in glass tubes with a restricted air supply, and incubated at 25°C. Yeast and mold colony-forming units (CFU) were counted on selective media after 14 days. Pichia anomala reached a density of about 5 x 107CFU/g on all tested cereals except in spring wheat (cv. Dragon), where a density of 109CFU/g was reached. In winter wheat (cv.

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20

CAMPANIELLO, DANIELA, MARIA ROSARIA CORBO, and MILENA SINIGAGLIA. "Antifungal Activity of Eugenol against Penicillium, Aspergillus, and Fusarium Species." Journal of Food Protection 73, no. 6 (2010): 1124–28. http://dx.doi.org/10.4315/0362-028x-73.6.1124.

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The antifungal activity of eugenol in a model system against aspergilli (Aspergillus niger, Aspergillus terreus, and Emericella nidulans), penicilli (Penicillium expansum, Penicillium glabrum, and Penicillium italicum), and fusaria (Fusarium oxysporum and Fusarium avenaceum) was investigated. Minimum detection time (time to attain a colony diameter of 1 cm) and the kinetic parameters were evaluated. The effectiveness of the active compound seemed to be strain or genus dependent; 100 mg/liter represented a critical value for P. expansum, P. glabrum, P. italicum, A. niger, and E. nidulans becaus

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Koetsier, Martijn J., Peter A. Jekel, Marco A. van den Berg, Roel A. L. Bovenberg, and Dick B. Janssen. "Characterization of a phenylacetate–CoA ligase from Penicillium chrysogenum." Biochemical Journal 417, no. 2 (2008): 467–76. http://dx.doi.org/10.1042/bj20081257.

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Enzymatic activation of PAA (phenylacetic acid) to phenylacetyl-CoA is an important step in the biosynthesis of the β-lactam antibiotic penicillin G by the fungus Penicillium chrysogenum. CoA esters of PAA and POA (phenoxyacetic acid) act as acyl donors in the exchange of the aminoadipyl side chain of isopenicillin N to produce penicillin G or penicillin V. The phl gene, encoding a PCL (phenylacetate–CoA ligase), was cloned in Escherichia coli as a maltose-binding protein fusion and the biochemical properties of the enzyme were characterized. The recombinant fusion protein converted PAA into p

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22

COOPER, CHESTER R., and NEIL G. HAYCOCKS. "Penicillium marneffei: An Insurgent Species Among the Penicillia1." Journal of Eukaryotic Microbiology 47, no. 1 (2000): 24–28. http://dx.doi.org/10.1111/j.1550-7408.2000.tb00006.x.

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FINOLI, CARLO, ANGELA VECCHIO, ANTONIETTA GALLI, and IVAN DRAGONI. "Roquefortine C Occurrence in Blue Cheese." Journal of Food Protection 64, no. 2 (2001): 246–51. http://dx.doi.org/10.4315/0362-028x-64.2.246.

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Several strains of Penicillium are used for the production of mold-ripened cheeses, and some of them are able to produce mycotoxins. The aims of the research were the determination of roquefortine C and PR toxin in domestic and imported blue cheeses, the identification of the penicillia used as starter, and the investigation of their capacity for producing toxins in culture media. Roquefortine C was always found in the cheeses at levels ranging from 0.05 to 1.47 mg/kg, whereas the PR toxin was never found. The identification of the fungal strains present in the domestic cheeses included Penici

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24

Renno, Didier V., Gunter Saunders, Alan T. Bull, and Geoffrey Holt. "Transcript analysis of penicillin genes from Penicillium chrysogenum." Current Genetics 21, no. 1 (1992): 49–54. http://dx.doi.org/10.1007/bf00318654.

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25

de Jonge, Lodewijk P., Nicolaas A. A. Buijs, Angela ten Pierick, et al. "Scale-down of penicillin production in Penicillium chrysogenum." Biotechnology Journal 6, no. 8 (2011): 944–58. http://dx.doi.org/10.1002/biot.201000409.

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Mansouri, Aouatef, Majida Hafidi, Hamid Mazouz, Rachid Zouhair, Miloud El Karbane, and Hassan Hajjaj. "Mycoflora and Patulin-producing strains of cereals in North-Western Morocco." South Asian Journal of Experimental Biology 4, no. 5 (2015): 276–82. http://dx.doi.org/10.38150/sajeb.4(5).p276-282.

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Cereals are considered a food that is exposed to fungal contamination and mycotoxin production. The present study was conducted to evaluate and identify the patulin-producing fungal flora contaminating the wheat and bar-ley grain in the field, the storage silo, and products of transformation (flour, semolina). Sampling was carried out in the region of Meknes (Morocco) dur-ing the growing season of 2012. The study of macroscopic and microscopic characters enabled to isolate and identify over 140 isolates belonging mainly to the genuses Aspergillus, Penicillium, Fusarium, Cladosporium, Alternari

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27

Peng, Ling, Liangwei Li, Xiaochuan Liu, et al. "Chromosome-Level Comprehensive Genome of Mangrove Sediment-Derived Fungus Penicillium variabile HXQ-H-1." Journal of Fungi 6, no. 1 (2019): 7. http://dx.doi.org/10.3390/jof6010007.

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Penicillium is an ascomycetous genus widely distributed in the natural environment and is one of the dominant fungi involved in the decomposition of mangroves, which can produce a variety of antitumor compounds and bioactive substances. However, in mangrove ecosystems there is no complete genome in this genus. In this study, we isolated a fungus strain named Penicillium variabile HXQ-H-1 from coast mangrove (Fujian Province, China). We generated a chromosome-level genome with total size of 33.32 Mb, scaffold N50 of 5.23 Mb and contig N50 of 96.74 kb. Additionally, we anchored about 95.91% asse

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BATTILANI, PAOLA, AMEDEO PIETRI, PAOLA GIORNI, et al. "Penicillium Populations in Dry-Cured Ham Manufacturing Plants." Journal of Food Protection 70, no. 4 (2007): 975–80. http://dx.doi.org/10.4315/0362-028x-70.4.975.

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Seven ham manufacturing plants were sampled for 1 year to assess the mycoflora present in the air and on hams, with special attention given to potential mycotoxin producers. Temperature and relative humidity were recorded in the ripening rooms. Maturing rooms held hams from 2 to 3 through 6 to 7 ripening months, and aging rooms held hams for the following 6 to 7 months, until the 14-month ripening point, when they were ready for the market. Mean temperatures and relative humidities registered during the study were 14.9°C and 62.4%, respectively, in maturing rooms and 16.3°C and 57.6% in aging

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van de Kamp, Mart, Theo A. Schuurs, Arnold Vos, Ted R. van der Lende, Wil N. Konings, and Arnold J. M. Driessen. "Sulfur Regulation of the Sulfate Transporter GenessutA and sutB in Penicillium chrysogenum." Applied and Environmental Microbiology 66, no. 10 (2000): 4536–38. http://dx.doi.org/10.1128/aem.66.10.4536-4538.2000.

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ABSTRACT Penicillium chrysogenum uses sulfate as a source of sulfur for the biosynthesis of penicillin. Sulfate uptake and the mRNA levels of the sulfate transporter-encoding sutB andsutA genes are all reduced by high sulfate concentrations and are elevated by sulfate starvation. In a high-penicillin-yielding strain, sutB is effectively transcribed even in the presence of excess sulfate. This deregulation may facilitate the efficient incorporation of sulfur into cysteine and penicillin.

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Myazin, Vladimir A., Maria V. Korneykova, Alexandra A. Chaporgina, Nadezhda V. Fokina, and Galina K. Vasilyeva. "The Effectiveness of Biostimulation, Bioaugmentation and Sorption-Biological Treatment of Soil Contaminated with Petroleum Products in the Russian Subarctic." Microorganisms 9, no. 8 (2021): 1722. http://dx.doi.org/10.3390/microorganisms9081722.

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The effectiveness of different bioremediation methods (biostimulation, bioaugmentation, the sorption-biological method) for the restoration of soil contaminated with petroleum products in the Russian Subarctic has been studied. The object of the study includes soil contaminated for 20 years with petroleum products. By laboratory experiment, we established five types of microfungi that most intensively decompose petroleum hydrocarbons: Penicillium canescens st. 1, Penicillium simplicissimum st. 1, Penicillum commune, Penicillium ochrochloron, and Penicillium restrictum. One day after the start

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Wiharyani, Risma, Dudi Hardianto, Hermin Pancasakti Kusumaningrum, and Anto Budiharjo. "Kloning Gen pcbC dari Penicillium chrysogenum ke dalam Plasmid pPICZA untuk Pengembangan Produksi Penisilin G." Bioma : Berkala Ilmiah Biologi 16, no. 1 (2014): 33. http://dx.doi.org/10.14710/bioma.16.1.33-38.

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Availability of drugs in Indonesia is still limited by the high prices of drugs due to on the imported raw materials that reaches 95%. Developing antibiotic raw materials can be achieved by increasing of penicillin G production, which is the raw material for the formation of semisynthetic penicillin derivatives through the production of 6-aminopenisillanic acid (6-APA). One of the important enzyme in the penicillin G biosynthesis is Isopenisilin N Synthase (IPNS) that encodes by pcbC gene on Penicillium chrysogenum. This study aimed to obtain a recombinant of pcbC gene fragments that is insert

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32

Šmidák, Roman, Martina Kralovičová, Beatrica Ševčíková, et al. "Sequence analysis and gene amplification study of the penicillin biosynthesis gene cluster from different strains of Penicillium chrysogenum." Biologia 65, no. 1 (2010): 1–6. http://dx.doi.org/10.2478/s11756-009-0216-2.

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AbstractIndustrial strains of Penicillium chrysogenum possess many genomic changes leading to higher levels of penicillin. In this work several production and wild-type strains of Penicillium chrysogenum were used in comparative nucleotide sequence analysis of the biosynthesis cluster. The alignments confirmed sequence conservation not only in promoter regions of the biosynthesis genes but also throughout the entire 44.7-kbp genomic fragment comprising the whole biosynthesis cluster with 15.5-kbp and 13.1-kbp flanking regions. As another titre-enhancing mechanism we subsequently examined gene

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Kurzątkowski, Wieslaw, and Anita Gębska-Kuczerowska. "Pexophagy in Penicillin G Secretion by Penicillium chrysogenum PQ-96." Polish Journal of Microbiology 65, no. 3 (2016): 365–68. http://dx.doi.org/10.5604/17331331.1215616.

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Penicillin G oversecretion by Penicillium chrysogenum PQ-96 is associated with a strictly adjusted cellular organization of the mature and senescent mycelial cells. Abundant vacuolar phagy and extended cellular vacuolization combined with vacuolar budding resulting in the formation of vacuolar vesicles that fuse with the cell membrane are the most important characteristic features of those cells. We suggest as follows: if the peroxisomes are integrated into vacuoles, the penicillin G formed in peroxisomes might be transferred to vacuoles and later secreted out of the cells by an exocytosis pro

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Martín, Juan F. "Insight into the Genome of Diverse Penicillium chrysogenum Strains: Specific Genes, Cluster Duplications and DNA Fragment Translocations." International Journal of Molecular Sciences 21, no. 11 (2020): 3936. http://dx.doi.org/10.3390/ijms21113936.

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Background: There are eighteen species within the Penicillium genus section chrysogena, including the original penicillin producers Penicillium notatum (Fleming strain) and Penicillium chrysogenum NRRL 1951. Other wild type isolates of the Penicillium genus are relevant for the production of useful proteins and primary or secondary metabolites. The aim of this article is to characterize strain specific genes and those genes which are involved in secondary metabolite biosynthesis, particularly the mutations that have been introduced during the β-lactams strain improvement programs. Results: The

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Aljeldah, Mohammed, Hosam El-Sayyad, Nasreldin Elhadi, and Ali Rabaan. "Effect of Gamma-Rays on the Growth and Penicillin Production of Penicillium chrysogenum." Journal of Pure and Applied Microbiology 13, no. 2 (2019): 779–88. http://dx.doi.org/10.22207/jpam.13.2.13.

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Lu, Ying, Robert L. Mach, Karin Affenzeller та Christian P. Kubicek. "Regulation of α-aminoadipate reductase from Penicillium chrysogenum in relation to the flux from α-aminoadipate into penicillin biosynthesis". Canadian Journal of Microbiology 38, № 8 (1992): 758–63. http://dx.doi.org/10.1139/m92-123.

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The activity and regulation of α-aminoadipate reductase in three Penicillium chrysogenum strains (Q176, D6/1014/A, and P2), producing different amounts of penicillin, were studied. The enzyme exhibited decreasing affinity for α-aminoadipate with increasing capacity of the respective strain to produce penicillin. The enzyme from all three strains was inhibited by L-lysine, and the enzyme from the lowest producer, Q176, was least sensitive. Between pH 7.5 and 6.5, inhibition of α-aminoadipate reductase by L-lysine was pH dependent, being more pronounced at lower pH. The highest producer strain,

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MISLIVEC, PHILIP B., MARY W. TRUCKSESS, and LEONARD STOLOFF. "Effect of Other Toxigenic Mold Species on Aflatoxin Production by Aspergillus flavus in Sterile Broth Shake Culture." Journal of Food Protection 51, no. 6 (1988): 449–51. http://dx.doi.org/10.4315/0362-028x-51.6.449.

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The effect of Aspergillus ochraceus, A. versicolor, Penicillium citrinum, P. cyclopium and P. urticae on production of aflatoxin by A. flavus when grown together with A. flavus in rotary shake culture was investigated. The two aspergilli had no apparent effect on aflatoxin production, whereas all three Penicillium species substantially lowered aflatoxin production. The toxins that these penicillia produced when growing in pure culture were not found when the penicillia were grown with A. flavus. However, these toxins had no effect on aflatoxin production added to the growth media, nor did the

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CIBELLI, F., C. CICCARONE, C. ALTIERI, A. BEVILACQUA, and M. SINIGAGLIA. "Proteolytic Activity of Molds and Their Metabiotic Association with Salmonella in a Model System." Journal of Food Protection 71, no. 10 (2008): 2129–32. http://dx.doi.org/10.4315/0362-028x-71.10.2129.

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The aim of this study was to investigate the proteolytic ability of some strains of aspergilli, fusaria, and penicillia and the metabiotic effect of Fusarium oxysporum and Penicillium expansum on Salmonella. The proteolytic activity of the target molds was determined on tomato juice agar and tomato juice, whereas the metabiotic effect of F. oxysporum and P. expansum on Salmonella was assessed in a model system consisting of tryptone soy broth with different amounts of tomato juice added. Fusaria, some aspergilli, and one strain of penicillium showed a proteolytic activity on tomato juice agar.

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Scheckhuber, Christian Q., Marten Veenhuis, and Ida J. van der Klei. "Improving penicillin biosynthesis in Penicillium chrysogenum by glyoxalase overproduction." Metabolic Engineering 18 (July 2013): 36–43. http://dx.doi.org/10.1016/j.ymben.2013.04.003.

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Nawfa, Refdinal, Adi Setyo Purnomo, and Herdayanto Sulistyo Putro. "Synthesis of Antibiotic Penicillin-G Enzymatically by Penicillium chrysogenum." Asian Journal of Chemistry 31, no. 10 (2019): 2367–69. http://dx.doi.org/10.14233/ajchem.2019.21766.

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Penicillin-G antibiotic was used as the basic ingredient of making antibiotic type β-lactam such as tetracycline, amoxicillin, ampicillin and other antibiotics. Penicillin-G was splited into 6-amino penicillanic acid as the source of β-lactam. The biosynthetic pathway for the formation of penicillin-G in Penicillium chrysogenum cell through the formation of intermediates was carried out in the form of amino acids such as α-aminoadipate, L-cysteine, L-valine which are formed from glucose (food ingredients).The formation of 6-amino penicillanic acid is an amino acid combination of L-cysteine and

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Demjanová, Soňa, Pavlina Jevinová, Monika Pipová, and Ivana Regecová. "Identification of Penicillium verrucosum, Penicillium commune, and Penicillium crustosum Isolated from Chicken Eggs." Processes 9, no. 1 (2020): 53. http://dx.doi.org/10.3390/pr9010053.

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Penicillium species belong to main causative agents of food spoilage leading to significant economic losses and potential health risk for consumers. These fungi have been isolated from various food matrices, including table eggs. In this study, both conventional Polymerase Chain Reaction (PCR) and Polymerase Chain Reaction-Internal Transcribed Spacer-Restriction Fragment Length Polymorphism (PCR-ITS-RFLP) methods were used for species identification of Penicillium (P.) spp. isolated from the eggshells of moldy chicken eggs. Seven restriction endonucleases (Bsp1286I, XmaI, HaeIII, HinfI, MseI,

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Jodi, S. M., and J. O. Ehinmidu. "ISOLATION AND ANTI FUNGAL SUSCEPTIBILITIES OF PHYTOPATHOGENIC FUNGI FROM INFECTED YAM LEAVES IN ZARIA, NIGERIA." FUDMA JOURNAL OF SCIENCES 5, no. 3 (2021): 413–18. http://dx.doi.org/10.33003/fjs-2021-0503-1124.

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In order to study the disease causing organisms that reduces the quantity and quality of yam produced, which makes them unappealing to consumers, isolation of phytopathogenic fungi from infected yam leaves in the field at Zaria was carried out. The phytopathogenic infected yam leaves were surface sterilized with 70% alcohol, swabbed aseptically with sterile cotton swab stick and then inoculated on sterile Sabourand dextrose agar (SDA) suplimented with 0.1% of penicillin and streptomycin. The inoculated plates were incubated at 300C for 5 days. The growth were isolated in pure culture, and then

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Spröte, Petra, Axel A. Brakhage, and Michael J. Hynes. "Contribution of Peroxisomes to Penicillin Biosynthesis in Aspergillus nidulans." Eukaryotic Cell 8, no. 3 (2009): 421–23. http://dx.doi.org/10.1128/ec.00374-08.

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ABSTRACT Peroxisomal localization of the third enzyme of the penicillin biosynthesis pathway of Aspergillus nidulans, acyl-coenzyme A:IPN acyltransferase (IAT), is mediated by its atypical peroxisomal targeting signal 1 (PTS1). However, mislocalization of IAT by deletion of either its PTS1 or of genes encoding proteins involved in peroxisome formation or transport does not completely abolish penicillin biosynthesis. This is in contrast to the effects of IAT mislocalization in Penicillium chrysogenum.

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Hasanah, Nurul, Nurhayana Sennang, and Benny Rusli. "ASPERGILLUS GLAUCUS GROUP DAN PENICILLIUM SP DI RUANG OPERASI BEDAH SARAF." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 21, no. 2 (2018): 158. http://dx.doi.org/10.24293/ijcpml.v21i2.1100.

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Nosocomial infections occur widely in the world, most of them were in the poor and developing countries, because those infectiondiseases were still the mayor cause of high morbidity and mortality. All microorganisms including fungi may cause nosocomial infection.The fungal as opportunistic pathogens can threat immunocompromised patients such as neurosurgical patients and HIV/AIDS patients.The aim of this study was to identify the fungal species found in the neurosurgery and HIV/AIDS rooms at Dr. Wahidin SudirohusodoHospital Makassar. This study was a cross sectional study. The sample was the a

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Saeednejad, Zanjani L., A. Sabokbar, and A. Bakhtiari. "Recognition and differentiation of various Penicillium species, Penicillium citrinum, Penicillium notatum, Penicillium oxalicum and Penicillium frequentans, using random amplified polymorphic DNA-polymerase chain reaction technique." African Journal of Microbiology Research 6, no. 39 (2012): 6793–98. http://dx.doi.org/10.5897/ajmr12.1115.

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KURZĄTKOWSKI, WIESŁAW, MONIKA STANISZEWSKA, MAŁGORZATA BONDARYK, and ANITA GĘBSKA-KUCZEROWSKA. "Compartmentalization in Penicillin G Biosynthesis by Penicillium chrysogenum PQ-96." Polish Journal of Microbiology 63, no. 4 (2014): 399–408. http://dx.doi.org/10.33073/pjm-2014-054.

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The arrangement of organelles in the sub-apical productive non-growing vacuolated hyphal cells of the high- and the low-penicillin-pro- ducing strains Penicillium chrysogenum was compared using transmission electron microscopy. In the productive cells of the high-yielding strain the endoplasmic reticulum and the polyribosomes with associated peroxisomes are frequently arranged at the periphery of the cytoplasm and around the vacuoles. At the high activity of penicillin G biosynthesis the immuno-label of the cytosolic isopenicillin N synthase is concentrated at the polyribosomes arranged in the

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raman, tuhina, and Thomas Jefferson. "PENICILLIUM LUNG." Critical Care Medicine 33 (December 2005): A181. http://dx.doi.org/10.1097/00003246-200512002-00641.

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Koul, Mytre, and Shashank Singh. "Penicillium spp." Anti-Cancer Drugs 28, no. 1 (2017): 11–30. http://dx.doi.org/10.1097/cad.0000000000000423.

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&NA;. "Penicillium marneffei." AIDS 6, no. 2 (1992): 240–42. http://dx.doi.org/10.1097/00002030-199202000-00021.

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Yoshida, Kazuko, Takesuke Hiraoka, Masayuki Ando, Katsuhisa Uchida, and Vahid Mohsenin. "Penicillium decumbens." Chest 101, no. 4 (1992): 1152–53. http://dx.doi.org/10.1378/chest.101.4.1152.

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