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Journal articles on the topic 'Pentamethoxyflavone'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Sookkhee, Siriwoot, Choompone Sakonwasun, Pitchaya Mungkornasawakul, Phadungkiat Khamnoi, Nitwara Wikan, and Wutigri Nimlamool. "Synergistic Effects of Some Methoxyflavones Extracted from Rhizome of Kaempferia parviflora Combined with Gentamicin against Carbapenem-Resistant Strains of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii." Plants 11, no. 22 (2022): 3128. http://dx.doi.org/10.3390/plants11223128.

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The present study aimed to investigate the antibacterial activity of ethanolic Kaempferia parviflora extracts and the combined effects of the plant’s specific compounds with gentamicin against clinical strains of carbapenem-resistant Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii. The minimal inhibitory concentrations (MIC) of gentamicin and Kaempferia parviflora extracts against the tested bacterial strains were determined by using broth microdilution. The combined effects of Kaempferia parviflora extract and gentamicin were investigated by using a checkerboard ass

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2

Nakata, Asami, Yuka Koike, Hirofumi Matsui, Tsutomu Shimada, Masaki Aburada, and Jinwei Yang. "Potent SIRT1 Enzyme-stimulating and Anti-glycation Activities of Polymethoxyflavonoids from Kaempferia parviflora." Natural Product Communications 9, no. 9 (2014): 1934578X1400900. http://dx.doi.org/10.1177/1934578x1400900918.

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The SIRT1 enzyme-stimulating and anti-glycation activities of Kaempferia parviflora extract and its main polymethoxyflavonoids were evaluated in vitro. K. parviflora extract elevated SIRT1 catalytic activity by eight- and 17-fold at 20 μg/mL and 100 μg/mL, respectively, compared with vehicle only. Two major polymethoxyflavonoids, 3,5,7,3′,4′-pentamethoxyflavone (4) and 5,7,4′-trimethoxyflavone (5), were isolated from this extract and are four- and fivefold more potent than resveratrol, hitherto the strongest known natural SIRT1 activator. In addition, the anti-glycation activity of K. parviflo

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3

Ortega, Joseph T., María Luisa Serrano, Alírica I. Suárez, Jani Baptista, Flor H. Pujol, and Héctor R. Rangel. "Methoxyflavones from Marcetia taxifolia as HIV-1 Reverse Transcriptase Inhibitors." Natural Product Communications 12, no. 11 (2017): 1934578X1701201. http://dx.doi.org/10.1177/1934578x1701201104.

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Methoxyflavones are flavonoid widely distributed in plants and has been reported as potent antitumor agents and some of them have shown activity against HIV-1. In this work, two methoxyflavones isolated from Marcetia taxifolia were evaluated in vitro and in silico as HIV-1 inhibitors. Pentamethoxyflavone (5,3’-dihydroxy-3,6,7,8,4’-pentamethoxyflavone) (PMF) and Hexamethoxyflavone (5-Hydroxy-3,6,7,8,3’,4’-hexamethoxyflavone) (HMF) showed activity against HIV-1. The EC50 for HMF was 0.05 μM and 0.04 μM for PMF. The methoxyflavones also inhibited HIV-1 reverse transcriptase (RT), with an IC50 of

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4

Dachriyanus, Rizal Fahmi, Melvyn V. Sargent, Brian W. Skelton, and Allan H. White. "5-Hydroxy-3,3′,4′,5′,7-pentamethoxyflavone (combretol)." Acta Crystallographica Section E Structure Reports Online 60, no. 1 (2003): o86—o88. http://dx.doi.org/10.1107/s1600536803027880.

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5

Ahmad, Viqar Uddin, and Nargis Ismail. "5-Hydroxy-3,6,7,2′,5′-pentamethoxyflavone from Inula grantioides." Phytochemistry 30, no. 3 (1991): 1040–41. http://dx.doi.org/10.1016/0031-9422(91)85309-n.

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6

Zhang, Yuqin, Guohong Yan, Chengtao Sun, Huang Li, Yanhui Fu, and Wei Xu. "Apoptosis Effects of Dihydrokaempferol Isolated from Bauhinia championii on Synoviocytes." Evidence-Based Complementary and Alternative Medicine 2018 (December 2, 2018): 1–10. http://dx.doi.org/10.1155/2018/9806160.

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Bauhinia championii (Benth.) Benth. is a traditional medicinal plant used in China to treat rheumatoid arthritis (RA), especially in She ethnic minority group. This study focused on the active constituents from the rattan of B. championii (Benth.) Benth., which possess potential apoptosis effects. A conventional phytochemical separation method for the isolation of compounds from the ethyl acetate extract of B. championii was developed. The procedure involved extraction, liquid–liquid partitioning with ethyl acetate, and subsequent compound purification, respectively. Additionally, cell viabili

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Budzianowski, Jaromir, and Eckhard Wollenweber. "Rare Flavones from the Glandular Leaf Exudate of the Oxlip, Primula Elatior L." Natural Product Communications 2, no. 3 (2007): 1934578X0700200. http://dx.doi.org/10.1177/1934578x0700200308.

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5,6,2′,3′,6′-Pentamethoxyflavone (1), together with 3′,5′-dihydroxy-4′-methoxyflavone (2), 2′-methoxyflavone, 3′-methoxyflavone, 3′,4′-dimethoxyflavone, 2′,5′-methoxyflavone, 3′-hydroxy-4′,5′-dimethoxyflavone, 3′,4′,5′-trimethoxyflavone, and 3′-hydroxy-4′,5′-methylenedioxyflavone were found in the leaf exudate of the oxlip, Primula elatior (Primulaceae). The structures of flavones 1 and 2 were substantiated by 2D NMR spectroscopy.

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8

Menelaou, Marios A., Hidelisa P. Henandez, Francisco A. Macías, et al. "Constituents of Calamintha ashei: Effects on Florida Sandhill Species." Natural Product Communications 5, no. 5 (2010): 1934578X1000500. http://dx.doi.org/10.1177/1934578x1000500505.

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Chemical constituents of the perennial shrub Calamintha ashei have been characterized as part of our investigation of the allelopathic properties of this plant. Besides the known monoterpenes, (+)-evodone, (-)-calaminthone and (+)-desacetylcalaminthone, fresh aerial parts of C. ashei provided six new menthofurans, two new germacrane sesquiterpenes, and the six, known flavonoids: 5-desmethoxynobiletin, 5-hydroxy-6,7,8,4′-tetramethoxyflavone, 5,4′-dihydroxy-6,7,8,3′-tetra-methoxyflavone, thymonin, 5,4′-dihydroxy-6,7-dimethoxyflavone and 6-hydroxy-7,3′-dimethoxyluteolin. The structures of the new

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9

Abboud, K. A., S. H. Simonsen, T. J. Mabry, and N. Fang. "Structure of a non-planar flavonol, 5,7,2'-trihydroxy-3,6,8,4',5'-pentamethoxyflavone." Acta Crystallographica Section C Crystal Structure Communications 45, no. 11 (1989): 1788–92. http://dx.doi.org/10.1107/s0108270189003355.

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10

García-Argáez, Aída N., Nadia M. González-Lugo, Hortensia Parra-Delgado, and Mariano Martínez-Vázquez. "Casimiroin, zapoterin, zapotin and 5,6,2′,3′,4′-pentamethoxyflavone from Casimiroa pubescens." Biochemical Systematics and Ecology 33, no. 4 (2005): 441–43. http://dx.doi.org/10.1016/j.bse.2004.11.004.

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11

Johann, Susana, Artur Smânia-Jr, Moacir G. Pizzolatti, Jan Schripsema, Raimundo Braz-Filho, and Alexsandro Branco. "Complete ¹H and 13C NMR assignments and anti fungal activity of two 8-hydroxy flavonoids in mixture." Anais da Academia Brasileira de Ciências 79, no. 2 (2007): 215–22. http://dx.doi.org/10.1590/s0001-37652007000200004.

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A mixture of the two new flavonols 8-hydroxy-3, 4', 5, 6, 7-pentamethoxyflavone (1) and 8-hydroxy-3, 3', 4', 5, 6, 7-hexamethoxyflavone (2) was isolated from a commercial sample of Citrus aurantifolia. An array of one- (¹HNMR, {¹H}-13C NMR, and APT-13C NMR) and two-dimensional NMR techniques (COSY, NOESY, HMQC and HMBC) was used to achieve the structural elucidation and the complete ¹H and 13C chemical shift assignments of these natural compounds. In addition, the antifungal activity of these compounds against phytopathogenic and human pathogenic fungi was investigated.

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12

Choi, Cheol-Hee, Kyung-Hoon Sun, Chun-San An, et al. "Reversal of P-glycoprotein-mediated multidrug resistance by 5,6,7,3′,4′-pentamethoxyflavone (Sinensetin)." Biochemical and Biophysical Research Communications 295, no. 4 (2002): 832–40. http://dx.doi.org/10.1016/s0006-291x(02)00755-6.

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13

Indriatmoko, Dimas Danang, Maulani Maulani, and Tarso Rudiana. "Calcium Decay Ability of Extracts Chromolaena odorata L. Leaves (Asteraceae) on Kidney Stones." JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA 9, no. 1 (2022): 24–31. http://dx.doi.org/10.20473/jfiki.v9i12022.24-31.

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Background: Kidney stones are one of the causes of chronic and acute kidney failure symptoms. The flavonoid compounds in Chromolaena odorata leave extract are thought to dissolve calcium in kidney stones. Objective: This study aims to determine the activity of Chromolaena odorata leaves extract as a laxative for calcium kidney stones and to characterize the active extract with a liquid chromatograph mass spectrometry. Methods: The leaves of Chromolaena odorata were extracted by ultrasonication method using 3 solvents in stages, namely n-hexane, ethyl acetate, and methanol. The powder for kidne

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14

Petreanu, Marcel, Emili Kamila Ferreira, Ana Paula M. Sagaz, et al. "Uncommon Trimethoxylated Flavonol Obtained fromRubus rosaefoliusLeaves and Its Antiproliferative Activity." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/341216.

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This study shows the evaluation the antiproliferative effect of the extract, fractions, and uncommon compounds isolated fromR. rosaefoliusleaves. The compounds were identified by conventional spectroscopic methods such as NMR-H1and C13and identified as 5,7-dihydroxy-6,8,4′-trimethoxyflavonol (1), 5-hydroxy-3,6,7,8,4′-pentamethoxyflavone (2), and tormentic acid (3). Both hexane and dichloromethane fractions showed selectivity for multidrug-resistant ovary cancer cell line (NCI-ADR/RES) with total growth inhibition values of 11.1 and 12.6 μg/ml, respectively. Compound1also showed selective activ

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15

Jansakul, Chaweewan, Kuldej Tachanaparuksa, Michael J. Mulvany, and Youwapa Sukpondma. "Relaxant mechanisms of 3, 5, 7, 3′, 4′-pentamethoxyflavone on isolated human cavernosum." European Journal of Pharmacology 691, no. 1-3 (2012): 235–44. http://dx.doi.org/10.1016/j.ejphar.2012.07.019.

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16

Choi, Cheol-Hee, Joon-Ho Kim, and Sang-Hyun Kim. "Reversal of P-glycoprotein-mediated MDR by 5,7,3′,4′,5′-pentamethoxyflavone and SAR." Biochemical and Biophysical Research Communications 320, no. 3 (2004): 672–79. http://dx.doi.org/10.1016/j.bbrc.2004.06.020.

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17

Seo, Sang-Hwan, Young-Choon Lee, and Hyung-In Moon. "Acetyl-cholinesterase Inhibitory Activity of Methoxyflavones Isolated from Kaempferia parviflora." Natural Product Communications 12, no. 1 (2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200107.

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MeOH extracts of Kaempferia parviflora Wall. ex. Baker, family Zingiberaceae, were consecutively partitioned with CHCl3, EtOAc, and n-BuOH. The CHCl3 fractions were diluted in distilled water with n-hexane–CH2Cl2 and three methoxyflavones were isolated from the CH2Cl2 extract. Based on spectral analysis and comparison of the spectral data with literature values, the compounds were identified as 3,5,7,3′,4′-pentamethoxyflavone (KP1), 5,7-dimethoxyflavone (KP2), and 5,7,4′-trimethoxyflavone (KP3). In relation to their possible effectiveness against Alzheimer's disease, these compounds were teste

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18

Reham, M. Samra, F. Soliman Amal, A. Zaki Ahmed, A. Hassan Madiha, and M. Zaghloul Ahmed. "Antiviral Components from Cleome droserifolia and Lotus creticus." Indian Journal of Science and Technology 13, no. 28 (2020): 2866–75. https://doi.org/10.17485/IJST/v13i28.980.

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Abstract <strong>Objectives:</strong> Searching for new antiviral compounds is important due to continuous appearance of new viral strains that resist the commonly used drugs and due to toxic side effects of some of these drugs. This current study was designed to investigate some herbs to discover new natural antiviral agents. <strong>Methods:</strong> Eight herbal extracts were screened for antiviral activities against Hepatitis A, Herpes Simplex-1 and Coxsackie viruses. Bio guided fractionation of the active extracts using different solvents and further investigation of the bi

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19

Feng, Sen-Ling, Zhong-Wen Yuan, Xiao-Jun Yao, et al. "Tangeretin, a citrus pentamethoxyflavone, antagonizes ABCB1-mediated multidrug resistance by inhibiting its transport function." Pharmacological Research 110 (August 2016): 193–204. http://dx.doi.org/10.1016/j.phrs.2016.04.003.

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20

Swamy, G. Y. S. K., K. Ravikumar, B. Sridhar, I. Mahender, and K. V. N. S. Srinivas. "Chains of edge-fused hydrogen-bondedR33(22) rings in 5,3′-dihydroxy-3,6,7,4′,5′-pentamethoxyflavone." Acta Crystallographica Section C Crystal Structure Communications 62, no. 8 (2006): o495—o497. http://dx.doi.org/10.1107/s0108270106023675.

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21

Okuno, Yoshiharu, and Mitsuo Miyazawa. "Biotransformation of Nobiletin byAspergillusnigerand the Antimutagenic Activity of a Metabolite, 4‘-Hydroxy-5,6,7,8,3‘-pentamethoxyflavone." Journal of Natural Products 67, no. 11 (2004): 1876–78. http://dx.doi.org/10.1021/np034007g.

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22

Dewi, Kristin Shinta, Euis Julaeha, Kindi Farabi, and Unang Supratman. "Flavonoids from Limau Peel (Citrus amblycarpa (Hassk.) Ochse) and Their Antioxidant Activity." Molekul 17, no. 2 (2022): 193. http://dx.doi.org/10.20884/1.jm.2022.17.2.5430.

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Citrus amblycarpa (Hassk.) Ochse is an endemic Indonesian plant from West Java. This study aims to determine the chemical structure of the flavonoid compounds of C. amblycarpa peel ethanol extract and their antioxidant activity. Three flavonoid compounds, namely 5-hydroxy-3',4',6,7,8-pentamethoxyflavone (1), 8-hydroxy-3,3',4',5,6,7-hexamethoxyflavone (2), and 3',4',5,6,7,8-hexamethoxyflavone (3), were isolated for the first time from the ethanol extract of C. amblycarpa peel. Their chemical structure was determined by spectroscopic methods (MS, IR, 1H-NMR, 13C-NMR, and DEPT) and compared with

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23

Jakhar, Rekha, Souren Paul, Young Rong Park, Jaehong Han, and Sun Chul Kang. "3,5,7,3′,4′-Pentamethoxyflavone, a quercetin derivative protects DNA from oxidative challenges: Potential mechanism of action." Journal of Photochemistry and Photobiology B: Biology 131 (February 2014): 96–103. http://dx.doi.org/10.1016/j.jphotobiol.2014.01.003.

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24

Nguyen, Phi Hung. "METHOXYFLAVONES FROM ORTHOSIPHON STAMINEUS BENTH. AND THEIR PTP1B INHIBITORY ACTIVITIES." Vietnam Journal of Science and Technology 56, no. 4A (2018): 146. http://dx.doi.org/10.15625/2525-2518/56/4a/12877.

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Phytochemical analysis of the methanol extract of the aerial parts of Orthosiphon stamineus Benth. led to the isolation of four flavone compounds including 5-hydroxy-3,7,3′,4′-tetramethoxyflavone (1), 3,5,7,3′,4′-pentamethoxyflavone (2), 3,3′-dihydroxy-5,7,4′-trimethoxyflavone (3), and 3,5,3′-trihydroxy-7,4ʹ-dimethoxyflavone (4). Their chemical structures were determined from the spectroscopic evidences, including 1D-NMR and MS, respectively. The inhibitory effects of the isolates (1‒4) against protein tyrosine phosphatase 1B (PTP1B) enzyme were investigated in vitro using ursolic acid as posi

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Oleynits, Elena Yu, Viktor I. Deineka, Ivan S. Pronin, and Lyudmila A. Deineka. "SEPARATION OF POLYMETOXYLATED FLAVONE FROM CITRUS FRUIT FLAVEDO EXTRACTS UNDER “MONOMERIC” REVERSE PHASE HPLC CONDITIONS." ChemChemTech 67, no. 12 (2024): 25–32. https://doi.org/10.6060/ivkkt.20246712.7057.

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For the first time, the regularities of retention of six polymethoxylated flavones from orange peel were determined under reversed-phase chromatography on “monomeric” C18 stationary phases. These flavonoids have received recent attention as compounds with unique biological activities, including (supposedly) effects on the development of intractable Alzheimer's and Parkinson's diseases. Sinensetin (3′,4′,5,6,7-pentamethoxyflavone), 3′,4′,3,5,6,7-hexamethoxyflavone, nobiletin (3′,4′,5,6,7,8-hexamethoxyflavone), 4′,5,6,7-tetramethoxyflavone, 3′,4′,3,5,6,7,8-heptamethoxyflavone and tangeretin (4′,

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26

Santos, M. R. A., R. A. Lima, A. G. Silva, C. A. D. Teixeira, I. P. V. Alpirez, and V. A. Facundo. "Composição química e atividade inseticida do extrato acetônico de Piper alatabaccum Trel & Yuncker (Piperaceae) sobre Hypothenemus hampei Ferrari." Revista Brasileira de Plantas Medicinais 15, no. 3 (2013): 332–36. http://dx.doi.org/10.1590/s1516-05722013000300004.

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O presente trabalho teve como objetivo investigar a composição química e avaliar a atividade inseticida do extrato acetônico das raízes de Piper alatabaccum sobre Hypothenemus hampei. As raízes foram coletadas no campus da Universidade Federal de Rondônia, em Porto Velho-RO. Diluições de 100,0, 50,0, 25,0, 5,0 e 0,5 mg mL-1 foram utilizadas para exposição na superfície contaminada e aplicação tópica. No teste de repelência, utilizou-se as diluições de 25,0 e 100,0 mg mL-1. As avaliações ocorreram durante 48 horas após a exposição ao extrato. O extrato foi eficiente na mortalidade em aplicação

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27

Li, Zhenqing, Xin Chen, Lulu Qiu, Yu Wang, and Zhiqin Zhou. "Nano Porous Carbon Derived from Citrus Pomace for the Separation and Purification of PMFs in Citrus Processing Wastes." Nanomaterials 10, no. 10 (2020): 1914. http://dx.doi.org/10.3390/nano10101914.

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The by-product of citrus juice processing is a huge source of bioactive compounds, especially polymethoxyflavones (PMFs) and fibers. In this study, a method for the separation and purification of PMFs from citrus pomace was established based on citrus nanoporous carbon (CNPC) enrichment. Different biomass porous carbons were synthesized, their adsorption/desorption characteristics were evaluated, and the CNPCs from the peel of Citrus tangerina Tanaka were found to be best for the enrichment of PMFs from the crude extracts of citrus pomace. Using this method, six PMF compounds including low-abu

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28

Sawadogo, Wamtinga, Claudia Cerella, Ali Al-Mourabit, et al. "Cytotoxic, Antiproliferative and Pro-Apoptotic Effects of 5-Hydroxyl-6,7,3′,4′,5′-Pentamethoxyflavone Isolated from Lantana ukambensis." Nutrients 7, no. 12 (2015): 10388–97. http://dx.doi.org/10.3390/nu7125537.

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29

Hou, Xiangyu, Xupeng Bai, Xiaoli Gou, et al. "3′,4′,5′,5,7-Pentamethoxyflavone Sensitizes Cisplatin-Resistant A549 Cells to Cisplatin by Inhibition of Nrf2 Pathway." Molecules and Cells 38, no. 5 (2015): 396–401. http://dx.doi.org/10.14348/molcells.2015.2183.

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30

Yoon, Hoon Seok, Hee-Chul Ko, Sang Suk Kim, et al. "Tangeretin Triggers Melanogenesis through the Activation of Melanogenic Signaling Proteins and Sustained Extracellular Signal-Regulated Kinase in B16/F10 Murine Melanoma Cells." Natural Product Communications 10, no. 3 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000304.

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In order to test the effectiveness of tangeretin at ameliorating melanoma and melanoma-associated depigmentation, western blotting was used to assess the melanin content of treated melanoma cells. Tangeretin, a 4′,5,6,7,8-pentamethoxyflavone, was found to trigger intracellular melanin production in a concentration-dependent manner in B16/F10 murine melanoma cells. Melanin content increased 1.74-fold in response to treatment with 25 μM of tangeretin, compared to that in non-treated cells. Examination of melanogenic protein expression showed that tyrosinase, tyrosinase-related protein (TRP)-1, a

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31

Xu, Shuqing, Shuzhen Yang, Yanting Yang, et al. "Transcription factor CsWRKY76 potentially involved in accumulation of scoparone and pentamethoxyflavone in citrus fruit stimulated by salicylic acid." Postharvest Biology and Technology 228 (October 2025): 113672. https://doi.org/10.1016/j.postharvbio.2025.113672.

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Li, Zhenqing, Ziyan Zhao, and Zhiqin Zhou. "Simultaneous Separation and Purification of Five Polymethoxylated Flavones from “Dahongpao” Tangerine (Citrus tangerina Tanaka) Using Macroporous Adsorptive Resins Combined with Prep-HPLC." Molecules 23, no. 10 (2018): 2660. http://dx.doi.org/10.3390/molecules23102660.

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In this study, a preparative separation method was established to simultaneously isolate the polymethoxylated flavones (PMFs) from the peel of “Dahongpao” tangerine using macroporous adsorptive resins (MARs) combined with prep-HPLC. The total PMFs were enriched using MARs to remove most sugars, water-soluble pigments, and flavanones, and the eluents obtained were analyzed by ultra-performance liquid chromatography (UPLC) to determine the PMF composition. The separation and purification of PMFs were carried out by using a mass spectrometry-guided prep-HPLC with a gradient elution of acetonitril

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Klinngam, Wannita, Phetploy Rungkamoltip, Ratjika Wongwanakul, et al. "Skin Rejuvenation Efficacy and Safety Evaluation of Kaempferia parviflora Standardized Extract (BG100) in Human 3D Skin Models and Clinical Trial." Biomolecules 14, no. 7 (2024): 776. http://dx.doi.org/10.3390/biom14070776.

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Polymethoxyflavones from Kaempferia parviflora rhizomes have been shown to effectively combat aging in skin cells and tissues by inhibiting senescence, reducing oxidative stress, and enhancing skin structure and function. This study assessed the anti-aging effects and safety of standardized K. parviflora extract (BG100), enriched with polymethoxyflavones including 5,7-dimethoxyflavone, 5,7,4’-trimethoxyflavone, 3,5,7,3’,4’-pentamethoxyflavone, 3,5,7-trimethoxyflavone, and 3,5,7,4ʹ-tetramethoxyflavone. We evaluated BG100’s impact on skin rejuvenation and antioxidant properties using photoaged h

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Mayangsari, Yunika, Natsumi Sugimachi, Wenxi Xu, et al. "3,5,7,3′,4′-Pentamethoxyflavone Enhances the Barrier Function through Transcriptional Regulation of the Tight Junction in Human Intestinal Caco-2 Cells." Journal of Agricultural and Food Chemistry 69, no. 35 (2021): 10174–83. http://dx.doi.org/10.1021/acs.jafc.1c04295.

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35

Cai, Hong, Karen Brown, William P. Steward, and Andreas J. Gescher. "Determination of 3′,4′,5′,5,7-pentamethoxyflavone in the plasma and intestinal mucosa of mice by HPLC with UV detection." Biomedical Chromatography 23, no. 4 (2009): 335–39. http://dx.doi.org/10.1002/bmc.1120.

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36

Timotius, Kris Herawan, Ika Rahayu, and Agustina Dwi Retno Nurcahyanti. "Pimpinella pruatjan Molk: LC-MS/MS-QTFT Analysis of Bioactive Compounds from Decoction and Ethanol Extract of Aerial Parts." Journal of Pharmacy and Bioallied Sciences 15, no. 3 (2023): 158–63. http://dx.doi.org/10.4103/jpbs.jpbs_183_22.

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ABSTRACT Pimpinella pruatjan Molk is native to Java and well known as aphrodisiac in traditional medicine. A water-boiled extract of the plant has been used in the treatment of erectile dysfunction (ED). No study has been found on the phytochemical constituents and identification of corresponding biological activities in water and polar extract. This study is aimed to identify phytoconstituents of a decoction and ethanol extract from the aerial parts of P. pruatjan Molk. Liquid chromatography-tandem mass spectroscopy (LC-MS/MS) was used to analyze and predict the bioactive compounds in both ex

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Phan, Minh Giang, Thi Viet Huong Do, and Quoc Binh Nguyen. "Methylated Flavonols from Amomum koenigii J.F.Gmel. and Their Antimicrobial and Antioxidant Activities." Biochemistry Research International 2020 (February 18, 2020): 1–6. http://dx.doi.org/10.1155/2020/4812312.

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Methylated flavonols form a special group with modulating biological activities in comparison with kaempferol and quercetin. The present study isolated ten compounds including two kaempferol methyl ethers: 5-hydroxy-3,7,4′-trimethoxyflavone (1), 3-hydroxy-5,7,4′-trimethoxyflavone (6); four quercetin methyl ethers: retusin (5-hydroxy-3,7,3′,4′-tetramethoxyflavone) (4), 3,5-dihydroxy-7,3′,4′-trimethoxyflavone (5), 3,4′-dihydroxy-5,7,3′-trimethoxyflavone (7), and 3,5,7,3′,4′-pentamethoxyflavone (9); β-sitosterol (2); 5-hydroxy-1-(4′-hydroxyphenyl)eicosan-3-one (3); p-hydroquinone (8); and vanilli

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Temviriyanukul, Piya, Anchana Chansawhang, Jirarat Karinchai, et al. "Kaempferia parviflora Extracts Protect Neural Stem Cells from Amyloid Peptide-Mediated Inflammation in Co-Culture Model with Microglia." Nutrients 15, no. 5 (2023): 1098. http://dx.doi.org/10.3390/nu15051098.

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The existence of neuroinflammation and oxidative stress surrounding amyloid beta (Aβ) plaques, a hallmark of Alzheimer’s disease (AD), has been demonstrated and may result in the activation of neuronal death and inhibition of neurogenesis. Therefore, dysregulation of neuroinflammation and oxidative stress is one possible therapeutic target for AD. Kaempferia parviflora Wall. ex Baker (KP), a member of the Zingiberaceae family, possesses health-promoting benefits including anti-oxidative stress and anti-inflammation in vitro and in vivo with a high level of safety; however, the role of KP in su

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Feng, Sen-Ling, Zhong-Wen Yuan, Xiao-Jun Yao, et al. "Corrigendum to “Tangeretin, a citrus pentamethoxyflavone, antagonizes ABCB1-mediated multidrug resistance by inhibiting its transport function” [Pharm. Res. 110 (2016) 193–204]." Pharmacological Research 111 (September 2016): 545. http://dx.doi.org/10.1016/j.phrs.2016.07.014.

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Calderón, José S., Carlos L. Céspedes, Rosaura Rosas, et al. "Acetylcholinesterase and Insect Growth Inhibitory Activities of Gutierrezia microcephala on Fall Army worm Spodoptera frugiperda J. E. Smith." Zeitschrift für Naturforschung C 56, no. 5-6 (2001): 382–94. http://dx.doi.org/10.1515/znc-2001-5-611.

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From the aerial parts of Gutierrezia microcephala (Asteraceae), four oxyflavones were isolated, namely 5,7,2′-trihydroxy-3,6,8,4′,5′-pentamethoxyflavone (1); 5,7,4′-trihydroxy-3,6,8-trimethoxyflavone (2); 5,7,2′,4′-tetrahydroxy-3,6,8,5′-tetramethoxyflavone (3); 5,2′-dihydroxy- 3,6,7,8,4′,5′-hexamethoxyflavone (4), and an ent-clerodane, bacchabolivic acid (5). Compounds 1-5, the synthetic methyl ester (6 ), n-hexane and MeOH extracts were evaluated against the fall armyworm (Spodoptera frugiperda). Gedunin, a known insect growth regulator isolated from Cedrela spp. was used as a positive contro

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Paula, Vanderlúcia F., Luiz C. A. Barbosa, William Errington, Oliver W. Howarth, and Mariluze P. Cruz. "Chemical Constituents from Bombacopsis glabra (Pasq.) A. Robyns: Complete ¹H and 13C NMR Assignments and X Ray Structure of 5-Hydroxy-3,6,7,8,4'-pentamethoxyflavone." Journal of the Brazilian Chemical Society 13, no. 2 (2002): 276–80. http://dx.doi.org/10.1590/s0103-50532002000200022.

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Kikuchi, Hidehiko, Kaori Harata, Sumiko Akiyoshi, et al. "Bifunctional activity of tangeretin (5,6,7,8,4'-pentamethoxyflavone) in suppression of cell growth and gene expression of the superoxide-generating system-related proteins in U937 cells." Fundamental Toxicological Sciences 9, no. 5 (2022): 151–57. http://dx.doi.org/10.2131/fts.9.151.

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Arivazhagan, Lakshmi, та Subramanian Sorimuthu Pillai. "Tangeretin, a citrus pentamethoxyflavone, exerts cytostatic effect via p53/p21 up-regulation and suppresses metastasis in 7,12-dimethylbenz(α)anthracene-induced rat mammary carcinoma". Journal of Nutritional Biochemistry 25, № 11 (2014): 1140–53. http://dx.doi.org/10.1016/j.jnutbio.2014.06.007.

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e Silva, Davi Antas, Vivyanne S. Falcão-Silva, Ana Yara Serrano Gomes, et al. "Triterpenes and phenolic compounds isolated from the aerial parts ofHerissantia tiubaeand evaluation of 5,4′,-dihydroxy-3,6,7,8,3′-pentamethoxyflavone as a modulator of bacterial drug resistance." Pharmaceutical Biology 47, no. 4 (2009): 279–84. http://dx.doi.org/10.1080/13880200802436570.

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Guo, Shanshan, Xian Wu, Jinkai Zheng, Mingyue Song, Ping Dong, and Hang Xiao. "Anti-Inflammatory Property of 5-Demethylnobiletin (5-Hydroxy-6, 7, 8, 3′, 4′-pentamethoxyflavone) and Its Metabolites in Lipopolysaccharide (LPS)-Induced RAW 264.7 Cells." Biology 11, no. 12 (2022): 1820. http://dx.doi.org/10.3390/biology11121820.

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Hydroxylated polymethoxyflavones (PMFs) are a unique class of flavonoid compounds mainly found in citrus plants. We investigated the anti-inflammatory effects of one major 5-hydroxy PMF, namely 5-demethylnobiletin (5DN) and its metabolites 5, 3′-didemethylnobiletin (M1), 5, 4′-didemethylnobiletin (M2), and 5, 3′, 4′-tridemethylnobiletin (M3) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. The results showed that M2 and M3 produced stronger inhibitory effects on the production of nitric oxide (NO) than their parent compound at non-cytotoxic concentrations. Western blotting an

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Nea, Fatimata, Michel Boni Bitchi, Manon Genva, et al. "Phytochemical Investigation and Biological Activities of Lantana rhodesiensis." Molecules 26, no. 4 (2021): 846. http://dx.doi.org/10.3390/molecules26040846.

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Lantana rhodesiensis Moldenke is a plant widely used to treat diseases, such as rheumatism, diabetes, and malaria in traditional medicine. To better understand the traditional uses of this plant, a phytochemical study was undertaken, revealing a higher proportion of polyphenols, including flavonoids in L. rhodesiensis leaf extract and moderate proportion in stem and root extracts. The antioxidant activity of the extracts was also determined using three different assays: the radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, the FRAP method (Ferric-reducing antioxidant power) and

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Krongrawa, Wantanwa, Sontaya Limmatvapirat, Supachai Saibua, and Chutima Limmatvapirat. "Optimization of Ultrasound-Assisted Extraction of Yields and Total Methoxyflavone Contents from Kaempferia parviflora Rhizomes." Molecules 27, no. 13 (2022): 4162. http://dx.doi.org/10.3390/molecules27134162.

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The major bioactive components of Kaempferia parviflora (KP) rhizomes, 3,5,7,3′,4′-pentamethoxyflavone (PMF), 5,7-dimethoxyflavone (DMF), and 5,7,4′-trimethoxyflavone (TMF), were chosen as the quantitative and qualitative markers for this plant material. In order to extract bioactive components (total methoxyflavones) from KP rhizomes, ultrasound-assisted extraction (UAE) was proposed as part of this study. Plackett–Burman design (PBD) and Box–Behnken design (BBD) were utilized to optimize the effects of UAE on extraction yields and total methoxyflavone contents in KP rhizomes. First, PBD was

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Uddin, Md Josim, Daniela Russo, Md Mahbubur Rahman, et al. "Anticholinesterase Activity of Eight Medicinal Plant Species: In Vitro and In Silico Studies in the Search for Therapeutic Agents against Alzheimer’s Disease." Evidence-Based Complementary and Alternative Medicine 2021 (June 24, 2021): 1–14. http://dx.doi.org/10.1155/2021/9995614.

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Many Bangladeshi medicinal plants have been used to treat Alzheimer’s disease and other neurodegenerative diseases. In the present study, the anticholinesterase effects of eight selected Bangladeshi medicinal plant species were investigated. Species were selected based on the traditional uses against CNS-related diseases. Extracts were prepared using a gentle cold extraction method. In vitro cholinesterase inhibitory effects were measured by Ellman’s method in 96-well microplates. Blumea lacera (Compositae) and Cyclea barbata (Menispermaceae) were found to have the highest acetylcholinesterase

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Yorsin, Somruedee, Kanyanatt Kanokwiroon, Nisaudah Radenahmad та Chaweewan Jansakul. "Increased vascular eNOS and cystathionine-γ-lyase protein after 6 weeks oral administration of 3, 5, 7, 3′, 4′-pentamethoxyflavone to middle-aged male rats". Naunyn-Schmiedeberg's Archives of Pharmacology 389, № 11 (2016): 1183–94. http://dx.doi.org/10.1007/s00210-016-1280-0.

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Chen, Pei-Yi, Tzu-Ya Chao, Hao-Jen Hsu та ін. "The Lipid-Modulating Effect of Tangeretin on the Inhibition of Angiopoietin-like 3 (ANGPTL3) Gene Expression through Regulation of LXRα Activation in Hepatic Cells". International Journal of Molecular Sciences 22, № 18 (2021): 9853. http://dx.doi.org/10.3390/ijms22189853.

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The excessive accumulation of TG-rich lipoproteins (TGRLs) in plasma is associated with dyslipidemia and atherosclerotic cardiovascular diseases (ASCVDs). Tangeretin is a bioactive pentamethoxyflavone mainly found in citrus peels, and it has been reported to protect against hyperlipidemia, diabetes, and obesity. The aim of this study was to investigate the lipid-modulating effects and the underlying mechanisms of tangeretin action in hepatic cells. Transcriptome and bioinformatics analyses with the Gene Ontology (GO) database showed that tangeretin significantly regulated a set of 13 different

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