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Relevant bibliographies by topics / Peptide amiloide-β

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Academic literature on the topic 'Peptide amiloide-β'

Author: Grafiati

Published: 9 March 2023

Last updated: 10 March 2023

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Journal articles on the topic "Peptide amiloide-β"

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Bognanni, Noemi, Francesco Bellia, Maurizio Viale, Nadia Bertola, and Graziella Vecchio. "Exploring Charged Polymeric Cyclodextrins for Biomedical Applications." Molecules 26, no. 6 (2021): 1724. http://dx.doi.org/10.3390/molecules26061724.

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Over the years, cyclodextrin uses have been widely reviewed and their proprieties provide a very attractive approach in different biomedical applications. Cyclodextrins, due to their characteristics, are used to transport drugs and have also been studied as molecular chaperones with potential application in protein misfolding diseases. In this study, we designed cyclodextrin polymers containing different contents of β- or γ-cyclodextrin, and a different number of guanidinium positive charges. This allowed exploration of the influence of the charge in delivering a drug and the effect in the pro

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Zhytniakivska, Olga, Uliana Tarabara, Atanas Kurutos, Kateryna Vus, Valeriya Trusova, and Galyna Gorbenko. "Molecular Docking of Monomethine Cyanine Dyes to Lysozyme Amyloid Fibrils." 3, no. 3 (September 2, 2022): 142–48. http://dx.doi.org/10.26565/2312-4334-2022-3-18.

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Protein aggregation into highly ordered supramolecular aggregates is the hallmark of many degenerative diseases including the neurological disorders (Parkinson’s, Alzheimer’s, and Huntington’s diseases), type II diabetes, systemic amyloidosis, spongiform encephalopathies, etc. One of the simplest and effective methods for the identification and characterization of amyloid fibrils in vitro and the visualization of amyloid inclusions in vivo is based on the use of probes sensitive to the beta-pleated motifs. In the attempt to design new amyloid-sensing dyes or to optimization the existing molecu

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Romero Ramos, Nestor, Óscar Romero-Ramos, and Arnoldo José González Suárez. "Actividad física y funciones cognitivas en personas mayores: revisión sistemática de los últimos 5 años (Physical activity and cognitive functions in older people: a systematic review of the last 5 years)." Retos, no. 39 (August 2, 2020). http://dx.doi.org/10.47197/retos.v0i39.79960.

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 La actividad física (AF) afecta de manera positiva en la salud de las personas a cualquier edad, de acuerdo con los resultados de diferentes estudios en cuanto a la salud cognitiva de las personas mayores, los beneficios son más evidentes. Por esa razón, se ha realizado una revisión sistemática de la literatura científica que aborda los efectos de la AF en las funciones cognitivas (FC) de las personas mayores. Se consultaron cuatro bases de datos: Scopus, Web of Science, ScienceDirect, y Pub Med, y el buscador Scholar Google. Tras aplicar los criterios de selección, quedaron 31 artículo

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Martínez-Díaz, Jorge Antonio, María Elena Hernández-Aguilar, Fausto Rojas-Durán, et al. "Expression of proteins linked to Alzheimer’s disease in C6 rat glioma cells under the action of lipopolysaccharide (LPS), nimesulide, resveratrol and citalopram." Turkish Journal of Biochemistry, August 28, 2020. http://dx.doi.org/10.1515/tjb-2020-0091.

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AbstractObjectivesAlzheimer’s disease is complex and involves several proteins. Most affected are Tau protein and amyloid precursor protein (APP) which, when cleaved by the enzymes β-secretase (BACE1) and γ-secretase (Nicastrin), yield the amyloid peptide. Although these processes take place mainly in neurons, it is not exclusive of them, as glia cells also contribute to these processes. The objective of this study was to evaluate the effect of nimesulide, resveratrol and citalopram on C6 (glioma) cells when exposed to Lipopolysaccharide (LPS).MethodsExpression levels of the proteins APP, BACE

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Dissertations / Theses on the topic "Peptide amiloide-β"

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VILARDO, ELISA. "Il microRNA-101 regola la proteina precursore del peptide β-amiloide". Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2010. http://hdl.handle.net/2108/1175.

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Nella patogenesi della malattia di Alzheimer, il livello di espressione della proteina precursore del peptide β-amiloide (APP) riveste un ruolo determinante. E’ stato evidenziato che mutazioni che incrementano la sintesi proteica di APP, inclusa la duplicazione genica del locus di APP in alcune famiglie e nella trisomia del cromosoma 21, che contiene il gene APP, sono sufficienti per indurre lo sviluppo della patologia in forma precoce. Per questo motivo, la regolazione del gene APP è stata oggetto di intensi studi riguardanti sia la caratterizzazione del promotore, che le regioni 5’ e 3’ non

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RIZZA, FABIO. "Structural modelling of biological macromolecules: the cases of neurofibromin, bifurcating Electron Transferring Flavoprotein and Amyloid-β (1-16) peptide". Doctoral thesis, Università degli Studi di Milano-Bicocca, 2021. http://hdl.handle.net/10281/310480.

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In questa tesi sono stati affrontati tre progetti indipendenti, accomunati dall’uso della modellistica molecolare e in particolare della dinamica molecolare. Nel primo progetto è stato studiato il dominio Sec14-PH della neurofibromina (NF1). I domini sec14 sono stati scoperti in numerose proteine dai procarioti all’uomo come scambiatori di lipidi tra membrane, per mezzo di una tasca la cui apertura è legata al movimento di una specifica alpha-elica (elica lid). La struttura cristallina del dominio Sec14 di NF1 (sia del wild type sia di mutanti associati all’insorgenza della patologia neurofib

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Klementieva, Oxana. "Influence of Cu(II) and Glycodendrimers on Amyloid-beta-Peptide Aggregation." Doctoral thesis, Universitat Internacional de Catalunya, 2012. http://hdl.handle.net/10803/78910.

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La malaltia d’Alzheimer es caracteritza per l’acumulació de plaques extracel.lulars amiloides, formades pels anomenats pèptids amiloides (Aβ40). L’homeòstasi del coure (Cu) es veu afectada en l’etiologia de la malaltia d’Alzheimer, encara que el seu rol és un fet controvertit. Per a l’estudi de la influència del Cu(II) en l’agregació del pèptid amiloide, la morfologia i l’estructura secundària dels agregats amiloides formats en presència de Cu(II) s’han utilitzat AFM, TEM, SEM, SAXS, FTIR i espectrometria de fluorescència. A més, els efectes tòxics d’aquests agregats s’han estudiat en cèl.lul

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Bosch, Morató Mònica 1986. "The Role of intracellular amyloid β-peptide in the pathophysiology of GNE myopathy and Alzheimer's disease". Doctoral thesis, Universitat Pompeu Fabra, 2015. http://hdl.handle.net/10803/650351.

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The Amyloid β-peptide (Aβ) is accumulated in several diseases including GNE myopathy and Alzheimer’s disease (AD). GNE myopathy is a skeletal muscle disorder caused by biallelic mutations in the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) gene, which codifies for a key enzyme in sialic acid biosynthesis. The mutated GNE gene encodes a hypofunctional enzyme causing a decrease in cellular sialic acid. We have found that hyposialylation favors Aβ endocytosis in skeletal muscle cells, which is dependent on clathrin and heparan sulfate proteoglycan. Furthermore, we have obs

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Ramos, Fernández Eva 1984. "The Physiopathological role of nitric oxide in the brain : from translational regulation of the GluN2B subunit to post-translational modifications of albumin in Alzheimer's disease." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/129925.

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Nitric oxide (NO) is a molecule that has pleiotropic effects in brain and vascular system. Physiologically, NO induces the translation of the GluN2B subunit of N-methyl Daspartate receptor (NMDARc) by derepressing it 5’untranslated region (5’UTR) effect. This pathway is due to the activation of the heme regulated eIF2α (HRI) kinase and prevents an excess of GluN2B levels, especially at the extrasynaptic areas, where it can trigger excitotoxicity. Pathologically, NO in a pro-oxidant environment such as in Alzheimer’s Disease (AD) reacts with superoxide anion producing peroxynitrite, which

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Souza, Ana Cristina Guerra de. "Papel protetor do 2-feniletinil-butilterúrio em modelos de dano cognitivo em camundongos e na apoptose em células humanas." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/4467.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Memory is considered to be a process that has several stages, including acquisition, consolidation and retrieval. Memory impairment occurs when important synapses are modified. Alzheimer s disease (DA) is the most common cause of dementia. DA is characterized by cognitive damage, accumulation of the pathogenic amyloid-β (Aβ) peptide, and cholinergic dysfunction. Moreover, oxidative stress is associated with DA. Therapies used for dementia are still palliative rather than curative. Consequently, new therapies are urgently requi

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Gomes, Guilherme Monteiro. "Modulação do sistema das poliaminas e bloqueio seletivo de correntes de K+ do tipo A reverte o dano cognitivo induzido por peptídeo β-amiloide25-35". Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/4483.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>In Alzheimer s disease (AD), β-amyloid peptide (Aβ) has been linked with synaptic loss and cognitive dysfunction, albeit the precise mechanism remains unknown. An involvement of N-Methyl-D-Aspartate receptors (NMDAR) in AD is proposed, since its inhibition attenuates some aspects of AD s neuropathology. In this regard, polyamines, like spermidine and spermine, positive modulators of NMDARs, have been shown to have both concentration and synthesis increased by Aβ. Using the novel object recognition task we showed that negative mod

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Oliveira, Elodie Morais. "Relatórios de Estágio e Monografia intitulada"A influência da infecção microbiológica no desenvolvimento da Doença de Alzheimer"." Master's thesis, 2019. http://hdl.handle.net/10316/88275.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>A Doença de Alzheimer (DA) é uma doença neurodegenerativa, considerada a principal causa de demência a nível mundial. Afeta essencialmente os idosos e está associada a alterações a nível da memória e da orientação espacial. Descrita pela primeira vez em 1907 pelo médico Aloysius Alzheimer, caracteriza-se pela deposição de peptídeo β-amiloide (Aβ) e proteína tau hiperfosforilada, sob a forma de placas senis e de aglomerados neurofibrilares (NFTs), respetivamente. A deteção destas proteína

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Conference papers on the topic "Peptide amiloide-β"

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Azevedo, José Bruno da Silva, та JOSÉ BRUNO DA SILVA AZEVEDO. "REVISÃO BIBLIOGRÁFICA SOBRE A DOENÇA DO ALZHEIMER: HIPERFOSFORILAÇÃO DA PROTEÍNA TAU E DEPOSIÇÃO DO PEPTÍDEO β-AMILOSE." У I Congresso Nacional de Pesquisas e Estudos Genéticos On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/geneticon/8830.

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Introdução: A doença de Alzheimer é multifatorial ou poligênica e corresponde a cerca de 50 a 75 % de casos de demência nos seres humanos. A proteína TAU é importante na patogenia da demência frontotemporal e para o citoesqueleto neuronal. Essa proteína consegue interagir com a α- e βglobulina para estabilizar os microtúbulos que são essenciais no transporte axonal, na plasticidade sináptica e na manutenção da estrutura neural. Objetivos: Esse trabalho teve como objetivo conhecer as proteínas e os genes promotores no desenvolvimento da doença de alzheimer. Metodologia: Foi realizada uma busca

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Schwartz, Dauana, and Bruna Kuhn De Freitas Silva. "BIOSSENSORES NANOESTRUTURADOS PARA DETECÇÃO DE BIOMARCADORES EM DOENÇAS DE PERFIL NEUROLÓGICO." In II Congresso Brasileiro de Biotecnologia On-line. Revista Multidisciplinar de Educação e Meio Ambiente, 2022. http://dx.doi.org/10.51189/conbiotec/45.

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INTRODUÇÃO: A biocompatibilidade dos biosenssores, tem sido cada vez mais evidenciados em aplicações por meio de nanoestruturas com uma maior afinidade. Biomoléculas de DNA, enzimas, anticorpos e antígenos, são amplamente utilizadas devido a sua alta afinidade e estabilidade, reconhecendo com eficiência diferentes moléculas e organismos. A barreira hematoencefálica desempenha função principal relaciona a inibição da entrada de substâncias em seu interior, visando inibir a entrada de células indesejadas, íons e cloretos. Doenças de acometimento neurológico possuem uma deficiência em relação ao

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