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Dissertations / Theses on the topic 'Peptide binding'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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1

Zhang, Zhiwen. "Towards peptide-binding peptides." Access restricted to users with UT Austin EID, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3037037.

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2

Onkar, Sayali S. "Cholesterol Binding Activity of ApoAI Mimetic Peptide L4F." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1363726316.

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3

Barouch, Dan H. "Peptide binding and presentation by HLA-A2." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294263.

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4

Dunn, James Albert. "Single Molecule Characterization of Peptide/Hematite Binding." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1494014864020062.

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5

Widenbring, Ronja. "Microgel Interactions with Peptides and Proteins : Consequence of Peptide and Microgel Properties." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-242893.

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Microgels are lightly cross-linked hydrogel particles in the sub-micrometer to micrometer size range with a capacity to drastically change their volume in response to changes in the external environment. Microgels have an ability to bind and store substances such as biomacromolecular drugs, notably proteins and peptides, and release them upon stimuli, making them potential candidates as drug delivery vehicles and functional biomaterials. This thesis aims at clarifying important factors affecting peptide-microgel interactions. These interactions were studied by micromanipulator-assisted light a

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6

Umurtak, H. B. "Studies on DNA-binding peptides]." Thesis, University of Southampton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235192.

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7

Mansouri, Ahmad. "Computational modeling of osteopontin peptide binding to hydroxyapatite." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104546.

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Osteopontin (OPN), a secreted, noncollagenous, acidic, and mineral-binding phosphoprotein, is composed of 314 amino acids (in humans), mostly composed of glutamate, aspartate and serine. It is prominently associated with biominerals and has a regulatory effect on hydroxyapatite (HAP) crystal growth, the mineral phase of bones and teeth. Recent studies have revealed that OPN contains an acidic, serine- and aspartate-rich motif (ASARM), which potently inhibits mineralization of osteoblast cultures in a phosphate-dependent manner. ASARM peptides accumulate in hypophosphatemia patients whose disti

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8

Wareham, Richard Stuart. "Studies towards bicyclic macrocycles with peptide binding potential." Thesis, University of Southampton, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261113.

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9

Schouten, James Alexander. "Probing selective G-quadruplex binding using peptide motifs." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620018.

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10

Tran, Phuong My. "Anthrapyrazole cysteinyl peptides as inhibitors of AP-1 transcription factor binding." Thesis, De Montfort University, 1998. http://hdl.handle.net/2086/10703.

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Synthesis of peptides anchored to DNA by intercalating chromophores can incorporate the design principle of the naturally occurring peptide based antibiotics. This work is concerned with the synthesis of DNA anchored cysteinyl peptides designed to be potentially nucleotide sequence specific with possible affinity for the AP-l transcription site. Previous work has shown that anthraquinones and anthrapyrazoles (APZs) substituted with cationic side groups are excellent DNA intercalating agents. In this work a series of APZ analogues has been synthesised which are coupled onto the amino terminus o

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11

Martineau, Eric. "Modeling Peptide-binding Interactions and Polymer-binding Interactions and their Role in Mass Spectrometry." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/24197.

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As a first project, collision-induced dissociation experiments were carried out using electrospray ionisation mass spectrometry on gas phase complexes involving different poly(methylmetacrylate) oligomers with three amino acids: glycine, leucine, and phenylalanine. After acquiring breakdown diagrams, RRKM modeling was used to fit the experimental data in order to obtain the 0 K activation energy and the entropy of activation. These thermodynamic data were then used to understand the competing dissociation channels observed (except for gas phase complexes involving glycine that had only one dis

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12

Guelev, Vladimir Metodiev. "Peptide-based polyintercalators as sequence-specific DNA binding agents /." Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3008346.

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13

McIlroy, Brian Keith. "Protein kinase C phosphorylation dependent MARCKS peptide binding to calmodulin and acrylodan MARCKS peptide fluorescence /." The Ohio State University, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487687485808943.

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14

Jin, Yining. "Water dynamics at the MHCI-peptide binding interface studied by Hydrogen-deuterium exchange and structural studies of Apo A-I mimetic peptide-lipid binding." University of Toledo Health Science Campus / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=mco1404706445.

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15

Lim, Shan Nadia. "Comparative binding studies of PAM-2 peptides to the PABC domain, a highly specific peptide binding domain linked to ubiquitin and mRNA metabolism." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82279.

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The (Poly(A) Binding Protein C-terminal) PABC domain is found in the human ubiquitin E3 protein ligase, HYD, an orthologue of the Drosophila hyperplastic disc (HYD) tumor suppressor protein. The PABC domain is also found in the poly(A)-binding proteins (PABP), which are ubiquitous RNA binding proteins found in all eukaryotes. PABPs are implicated in stabilizing mRNA, recruiting translation factors, and regulating protein synthesis. Although HYD was shown previously to bind Paip1 (PABP interacting protein 1) in vitro, the function of the PABC domain in ubiquitin ligases remains unknown.

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16

Singh, Shalini. "Amphiphilic Peptide Interactions with Complex Biological Membranes : Effect of peptide properties on antimicrobial and anti-inflammatory effects." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282781.

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With increasing problem of resistance development in bacteria against conventional antibiotics, as well as problems associated with diseases either triggered or enhanced by infection, there is an urgent need to identify new types of effective therapeutics for the treatment of infectious diseases and its consequences. Antimicrobial and anti-inflammatory peptides have attracted considerable interest as potential new antibiotics in this context. While antimicrobial function of such peptides is being increasingly understood demonstrated to be due to bacterial membrane disruption, the mechanisms of

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17

Ijaz, Taeeba. "Anthraquinone-peptide conjugates as inhibitors of DNA transcription factor binding." Thesis, De Montfort University, 1998. http://hdl.handle.net/2086/10720.

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Inhibitors of Activator Protein-1 (AP-1)~ a collective term referring to dimeric transcription factors involved in mediating long term responses to signals that regulate growth control and development~ were designed and synthesised in this study. Truncated peptide sequences of 5-7 residues containing the highly conserved tri-amino acid sequence KCR found in the DNA binding domains of the AP-1 family of proteins were attached to mono-substituted anthraquinones through various amino acid type linkers. It was envisaged that these intercalator-linked peptides would have the advantage of high DNA b

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18

Utterström, Johanna. "One Bead One Compound Screening for Cyclic Peptide Binding Partners." Thesis, Linköpings universitet, Molekylär fysik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-152282.

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In recent years a significant research focus has been on the development of biomimicking three-dimensional substrates for cell culturing. Hydrogels mimicking the extracellular matrix is a well-suited scaffold for this purpose and there are many different ways these can be cross-linked to retain their shape. The group of Molecular Materials at IFM, Linköping University, is focusing on the development of physical hydrogels hybridized through peptide-peptide interactions but all peptides used for this today are created using rational design and on top of this very large, making them time-consumi

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19

Henriksson, Mikael. "Molecular aspects of proinsulin C-peptide interactions /." Stockholm : Department of medical biochemistry and biophysics, Karolinska institutet, 2006. http://diss.kib.ki.se/2006/91-7140-754-5/.

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20

Myers, Cheryl Eleanor. "CUSTOM DESIGNED MHC BINDING PEPTIDES FOR CANCER IMMUNOTHERAPY." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/194162.

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Cancer immunotherapy seeks to boost the host’s immune system to respond to tumor antigens. The adaptive immune system comprises of two arms, one that elicits a cellular immune response and one that elicits a humoral immune response. Cytotoxic T lymphocytes (CTL) recognize short antigenic peptides presented to them in the context of class I major histocompatibility complex (MHC) molecules and are capable of killing tumor cells. CTL are educated to discriminate between foreign and self-antigen. Tumors frequently express self-antigen which usually makes them poorly immunogenic. Because tumors are

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21

Lamikanra, Abigail Abibola. "Characterisation of mutations in class II MHC non-peptide binding domains." Thesis, Birkbeck (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267278.

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22

Pollock, Graeme Stuart. "Protein and peptide interactions with Immunoglobulin Heavy Chain Binding Protein (BiP)." Thesis, University of Kent, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240361.

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23

Zhong, Xun. "Design of ferrocene-peptide dimers for DNA binding and electrochemical sensing." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/5242/.

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GCN4 is a yeast transcriptional factor, which binds sequence selectively to DNA as a homodimer. Two domains are required to achieve this, an N-terminal basic domain, which interacts with the target site directly, and the C-terminal leucine zipper responsible for dimerisation. The latter can be replaced by chemically linking together two basic domains, to retain similar DNA binding. This work investigates using a ferrocene complex as the dimerization unit due to its flexibility and its characteristic electrochemical redox properties. A strategy was proposed which took advantage of coupling to t

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24

Kunkel, Jacquelyn Anne. "An examination of peptide-tether binding to gold and glass surfaces." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/54507.

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Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2009.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 14).<br>For many biological applications, it is beneficial to know that a peptide will bind to a surface. In this thesis, a tether, bead, peptide complex is constructed using the gold binding peptide (GBP) of sequence (CGGVSGSSPDS). Several assays and assay modifications are developed and tested to attempt to attach the GBP first to a gold slide and then to gold nanoparticles. Four peptides: FO₂, K1, K2, K3, known to bi

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25

Cassidy, Sorcha. "The peptide binding specificity of the inhibitory and activating KIR2D receptors." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/27222.

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Human natural killer (NK) cells play an invaluable role in the first line of innate immune defence against viral infection and cancer. They are the main sub-group of lymphocytes with predominant expression of polymorphic KIR (Killer-immunoglobulin-like-receptors), which allows them to engage with their MHC Class I ligands. Past immunogenetic analysis has shown that possession of KIR2DL3 may confer an advantage in eliminating acute Hepatitis C virus (HCV) infection. This contrasts with those possessing KIR2DL2 who were found not to spontaneously resolve infection. Previous work has shown that d

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26

Kunys, Andrew Richard. "Binding Specificity of SH2 Domains Revealed by a Combinatorial Peptide Library." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1374185732.

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27

Tang, Wen. "Bioactive Surface-Targeting Modular Peptide-Dendrons: Synthesis, Binding Affinity and Applicaiton." University of Akron / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=akron1406049913.

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28

Albati, Amal Abdulah. "PURIFICATION OF RECOMBINANT δ NP63 α AND CHARACTERIZATION OF PEPTIDE BINDING". Wright State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1447223071.

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29

Byerly, Douglas W. "Structure and dynamics of ligand binding to E. coli peptide deformylase /." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486463321624387.

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30

Patra, Sukanya. "Effect of a Holliday junction binding peptide, wrwycr, in human cells." Diss., [La Jolla, Calif.] : [San Diego] : University of California, San Diego ; San Diego State University, 2010. http://wwwlib.umi.com/cr/ucsd/fullcit?p3389701.

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Thesis (Ph. D.)--University of California, San Diego and San Diego State University, 2010.<br>Title from first page of PDF file (viewed February 17, 2010). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 151-166).

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31

Ghannad, Mona. "Design and Synthesis of Collagen-binding Anti-microbial Proteins." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19981.

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The Herpes simplex virus (HSV) is a virus that commonly infects the skin, and mucous membrane of the mouth, genitalia, and the eye. HSV-1 is the strain that is most commonly associated with corneal infections, and it is the most frequent cause of corneal blindness in North America [1]. Currently no cure is available, and many limitations are characterized by the currently available synthetic antiviral drugs, which suggest the need for other potential drug alternatives and delivery strategies. Anti-microbial peptides are naturally occurring peptides that are potent killers of a broad range of m

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32

Miller, Philip Saxon. "The role of the N-terminal domains of the CGRP receptor in binding peptide agonists and non-peptide antagonists." Thesis, University of Leeds, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534435.

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33

McCarthy, Kelly A. "Exploiting Dynamic Covalent Binding for Strain-Specific Bacterial Recognition:." Thesis, Boston College, 2018. http://hdl.handle.net/2345/bc-ir:108513.

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Thesis advisor: Eranthie Weerapana<br>Antibiotic resistance of bacterial pathogens poses an increasing threat to the wellbeing of our society and urgently calls for new strategies for infection diagnosis and antibiotic discovery. The overuse and misuse of broad-spectrum antibiotics has contributed to the antibiotic resistance crisis. Additionally, treatment of infections with broad-spectrum antibiotics can cause disruption to the host gut microbiome. The development of narrow-spectrum antibiotics would be ideal to avoid unnecessary cultivation of antibiotic resistance and damage to the human m

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34

Shidrawi, Ray Georges. "Molecular immune aspects of coeliac disease : organ culture and peptide binding studies." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243337.

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35

Mattock, Heidi. "Biochemical and functional analysis of a PCNA-binding peptide from p21 WAF1." Thesis, University of Dundee, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.706134.

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36

Wheeler, Lucas. "The Evolution of Metal and Peptide Binding in the S100 Protein Family." Thesis, University of Oregon, 2018. http://hdl.handle.net/1794/23178.

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Proteins perform an incredible array of functions facilitated by a diverse set of biochemical properties. Changing these properties is an essential molecular mechanism of evolutionary change, with major questions in protein evolution surrounding this topic. How do new functional biochemical features evolve? How do proteins change following gene duplication events? I used the S100 protein family as a model to probe these aspects of protein evolution. The S100s are signaling proteins that play a diverse range of biological roles binding Calcium ions, transition metal ions, and other prote

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37

Kharenko, Olesya A. "METAL-BINDING PROPERTIES OF SYNTHETIC METALLOPROTEINS." Bowling Green State University / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1126290895.

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38

Krabacher, Rachel M. "Identifying Unique Material Binding Peptides Using a High Throughput Method." University of Dayton / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1467888412.

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39

Mann, Rosalind Jane. "Selective peptide binding determinants on the N-terminal domain of parathyroid hormone receptors." Thesis, University of Leeds, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485164.

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The focus of this PhD work was to elucidate the mechanisms by which PTH2R mediates its ligand binding selectivity. The approach taken was to create a chimeric PTH creceptor with the aim of removing the selectivity filter from the PTH2R so that it would bind PTHrP(1-36). As residue 23 from PTHrP (shown to be responsible for its binding selectivity) has been cross linked to the extreme N-terminal region of the PTH1R, residues 1-41 from this receptor were introduced into the PTH2R. As both receptors bind PTH(1-34), it was expected that this chimeric receptor would also bind the ligand normally bu

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40

Kotamraj, Phanidhara R. "Binding induced enzyme activated methotrexate-α-peptide prodrugs for integrin targeted drug delivery". Scholarly Commons, 2009. https://scholarlycommons.pacific.edu/uop_etds/2619.

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Improving the therapeutic efficacy and quality of life of patients by reducing the side effects caused by non-specificity of cytotoxic drugs has been a challenge in cancer treatment. A hypothesis was developed where integrin binding induced conformational change in a drug conjugated to hairpin peptide with an integrin binding ligand can lead to preferential accumulation of drug and reduced collateral damage by decreased premature prodrug activation. A model drug, MTX and a tripeptide ligand, RGD, known to specifically bind tumor overexpressing α v β 3 integrin receptors, were selected to test

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41

Uslan, Volkan. "Support vector machine-based fuzzy systems for quantitative prediction of peptide binding affinity." Thesis, De Montfort University, 2015. http://hdl.handle.net/2086/11170.

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Reliable prediction of binding affinity of peptides is one of the most challenging but important complex modelling problems in the post-genome era due to the diversity and functionality of the peptides discovered. Generally, peptide binding prediction models are commonly used to find out whether a binding exists between a certain peptide(s) and a major histocompatibility complex (MHC) molecule(s). Recent research efforts have been focused on quantifying the binding predictions. The objective of this thesis is to develop reliable real-value predictive models through the use of fuzzy systems. A

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42

Pandya, Mital. "Definition of Bovine Leukocyte Antigen Diversity and Peptide Binding Profiles for Epitope Discovery." ScholarWorks @ UVM, 2016. http://scholarworks.uvm.edu/graddis/474.

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The goal of the work presented herein was to further our understanding of Bovine Leukocyte Antigen (BoLA) class I diversity of Holstein cattle and develop tools to measure class I restricted T cell responses to intracellular pathogens such as foot and mouth disease virus (FMDV) following vaccination. BoLA is a highly polymorphic gene region that allows the bovine immune system to differentiate pathogen-infected cells from healthy cells. Immune surveillance by CD8+ T cells plays an important role in clearing viral infections. These CD8+ T cells recognize BoLA class I molecules bearing epitopes

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43

Burke, Troy Anthony. "Investigation of the biological properties of TNF-#alpha# (alpha) derived peptides." Thesis, Queen's University Belfast, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268222.

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44

Davies, Thomas Glanmor. "Protein-ligand interactions for the OppA system." Thesis, University of York, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311012.

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45

Brown, Jennifer Louise. "Investigation of the molecular interactions between an anti-peptide antibody and its ligand." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318221.

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46

Yu, Jing. "An Atomistic Molecular Dynamics Study of the Binding of Peptides onto Gold Surfaces." University of Akron / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=akron1340294273.

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47

Nakath, Gamlath Ralalage Dayan Elshan. "Targeting Melanocortin and Cholecystokinin Receptors via Multivalent Molecules Bearing Peptide Ligands." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/338883.

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Peptide receptor overexpression in diseased cells and tissues, including carcinomas provides an opportunity to develop therapeutics and imaging agents that selectively bind to such cells and tissues. This dissertation presents tools and processes that can be utilized to target melanocortin and cholecystokinin receptors through multivalent binding. In Chapter 2, improved synthesis and purification methods are described for the production of Eu-chelated probes that serve to evaluate the binding efficacy of multivalent molecules through competition binding assays. Specifically, a xylenol orange-b

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48

Zhong, Zhihui. "Proinsulin c-peptide : membrane interactions and intracellular signaling /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-886-6.

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49

Kao, Jonathan. "Atrial natriuretic peptide in aging rats : evidence for altered processing, secretion and receptor binding." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/28993.

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The recently discovered atrial natriuretic peptide (ANP) has potent diuretic, natriuretic and hypotensive effects, and is believed to be involved in the maintenance of sodium homeostasis in both normal and pathological conditions. The mammalian aging process is associated with a host of abnormalities that include, among others, a compromised ability to regulate sodium homeostasis. There are reports that demonstrate a positive correlation between plasma ANP levels and age in man; accordingly, the aim of this study was to examine whether age-related sodium imbalance is associated with disturbanc

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50

Nasr, Elsayed Mohammed Nasr. "The binding and activation of the glucagon-like peptide-1 receptor by exendin-4." Thesis, University of Leeds, 2010. http://etheses.whiterose.ac.uk/1691/.

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Background and purpose Exendin-4 (EX4) has the same physiological properties as glucagon-like peptide-1 (7-36)amide (GLP-1). EX4 has 50% identity with GLP-1, with an extra nine amino acids at its C-terminus. The two peptides mediate their functions through coupling to the glucagon like peptide-1 receptor (GLP-1R) with similar affinity and potency. Unlike N-terminally truncated GLP-1, (GLP-1(15-36)amide), the equivalently truncated EX4(9-39) binds GLP-1R without significant loss of affinity; furthermore, GLP-1(15-36) is a partial agonist while EX4(9-39) is an antagonist. Previous binding analys

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