Log in

Relevant bibliographies by topics / Peptide effects / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Peptide effects.

Dissertations / Theses on the topic 'Peptide effects'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Peptide effects.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Ringstad, Lovisa. "Interaction Between Antimicrobial Peptides and Phospholipid Membranes Effects of Peptide Length and Composition /." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-101989.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Singh, Shalini. "Amphiphilic Peptide Interactions with Complex Biological Membranes : Effect of peptide properties on antimicrobial and anti-inflammatory effects." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282781.

Full text

Abstract:

With increasing problem of resistance development in bacteria against conventional antibiotics, as well as problems associated with diseases either triggered or enhanced by infection, there is an urgent need to identify new types of effective therapeutics for the treatment of infectious diseases and its consequences. Antimicrobial and anti-inflammatory peptides have attracted considerable interest as potential new antibiotics in this context. While antimicrobial function of such peptides is being increasingly understood demonstrated to be due to bacterial membrane disruption, the mechanisms of

APA, Harvard, Vancouver, ISO, and other styles

3

Kerstetter, Dale R. "McLafferty rearrangement of peptides and substituent effects on peptide fragmentation: Theoretical and experimental investigation." Thesis, Wichita State University, 2009. http://hdl.handle.net/10057/2541.

Full text

Abstract:

The research presented here details two studies that utilized theoretical analysis and experimentation to further the understading of peptide fragmentation. The first study was the McLafferty rearrangement, which involves transfer of a У-position hydrogen atom to a carbonyl oxygen atom through a cyclic intermediate, followed by the elimination of an alkene. The second study examined substituent effects on benzene ring terminated peptides.<br>Thesis (M.S.)--Wichita State University, College of Liberal Arts and Sciences, Dept. of Chemistry

APA, Harvard, Vancouver, ISO, and other styles

4

Matthews, Thomas. "The effects of environment on peptide stability." Thesis, Birkbeck (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406349.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Ng, Ming Tak. "Effects of prominsulin C-peptide and other islet peptides on beta-cell function and insulin secretion." Thesis, University of Ulster, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.554231.

Full text

Abstract:

Hyperglycaemia is a significant pathophysiological feature of diabetes mellitus. It has been considered to be a cause as well as a consequence of impaired pancreatic p-cell function and insulin action. The detrimental effects of a hyperglycaemic environment encourage the non-enzymatic glycation of regulatory and functional proteins. This thesis investigated the effects of pro insulin C-peptide and other important islet peptides such as insulin, somatostatin, islet amyloid polypeptide (IAPP) as well as the gut hormone gastric inhibitory polypeptide (GIP) in both native and glycated forms on ins

APA, Harvard, Vancouver, ISO, and other styles

6

Nsereko, Victor Leonard Joseph. "Peptidase inhibitors as additives for ensilage : effects on silage characteristics with reference to peptide nitrogen." Thesis, University of Aberdeen, 1996. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU079015.

Full text

Abstract:

Novel approaches to manipulating proteolysis in ensiled perennial ryegrass (PRG) were investigated. The effects of the following on nitrogen (N) distribution in silage were investigated: E- 64, a specific cysteine-peptidase inhibitor (CPI); pepstatin A a specific aspartic-peptidase inhibitor; cystamine dihyrochloride (CYS) and N-ethylmaleimide, general CPIs, and formic acid (FA). Treatment with FA or CPIs reduced total soluble N, as a result of reduced proteolysis, and FA and CYS treatments increased peptide N concentrations (determined using fluroescamine or ninhydrin assays, and by amino aci

APA, Harvard, Vancouver, ISO, and other styles

7

Milton, R. H. "The effects of beta-amyloid peptide on microglial function." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/19221/.

Full text

Abstract:

The role of microglia in Alzheimer’s Disease (AD) pathogenesis is widely acknowledged, and the beta-amyloid (Aβ) peptide which accumulates in AD brain is known to activate a range of microglial functions. In the present thesis, the acute induction of some of these processes is examined using live cell imaging techniques. Aβ causes activation of microglial NADPH oxidase, a membrane-localised enzyme system which produces reactive oxygen species (ROS) thereby engendering oxidative stress. The transfer of electrons across the membrane by this enzyme system to produce ROS generates a potential diff

APA, Harvard, Vancouver, ISO, and other styles

8

Strömstedt, Adam A. "Antimicrobial Peptide Interactions with Phospholipid Membranes : Effects of Peptide and Lipid Composition on Membrane Adsorption and Disruption." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-100966.

Full text

Abstract:

The interactions between antimicrobial peptides and phospholipid membranes were investigated, in terms of lipid headgroup variations and the role of cholesterol, as well as peptide composition and structure. Also strategies for increasing proteolytic stability were evaluated. The interactions were studied on model membranes in the form of liposomes and supported bilayers, through a combination of ellipsometry, fluorescence spectroscopy, circular dichroism, dynamic light scattering, electrophoresis, electron cryomicroscopy, and bacterial/cell culture experiments. The findings showed that membra

APA, Harvard, Vancouver, ISO, and other styles

9

Chilumuri, Amrutha. "The effects of catalase and kisspeptin overexpression on amyloid peptide toxicity." Thesis, University of Westminster, 2014. https://westminsterresearch.westminster.ac.uk/item/8yq40/the-effects-of-catalase-and-kisspeptin-overexpression-on-amyloid-peptide-toxicity.

Full text

Abstract:

Amyloid β (Aβ) is the major component of the senile plaques in Alzheimer’s disease (AD). The mechanism underlying cell death in AD includes oxidative stress, apoptosis, impaired mitochondrial function and receptor mediated effects. Compounds that specifically bind to Aβ are neuroprotective. Catalase is an antioxidant enzyme that specifically binds Aβ. Kisspeptin (KP) is a product of the KiSS-1 gene and contains an Aβ binding domain, which also interacts with Aβ. The localization of catalase, KP and Aβ in the AD brain plus the effects of catalase and KiSS-1 overexpression in neuronal cells were

APA, Harvard, Vancouver, ISO, and other styles

10

Demick, Kristen Ann. "Engineering Proteins via Peptide Backbone Mutagenesis: The Effects of Thioamide Linkages on the Folding and Stability of Short Peptides." Thesis, Boston College, 2009. http://hdl.handle.net/2345/724.

Full text

Abstract:

Thesis advisor: Jianmin Gao<br>The development of proteins/peptides as therapeutic agents has emerged as a promising area for drug design. Due to increased antibiotic resistance, search for novel antibiotics has become a primary area of interest within the pharmaceutical industry. Antimicrobial peptides have been a significantly desirable model due to their innate cytolytic effects and favorable interaction with the membranes of bacterial cells within the host. Thioxylated analogues of biologically active peptides have shown increased enzymatic stability and increased selectivity and potency.

APA, Harvard, Vancouver, ISO, and other styles

11

Sinclair, Elaine M. "GLP-1 effects on pancreatic b-cell lines." Thesis, University of Aberdeen, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252142.

Full text

Abstract:

The aims of this thesis were to establish a suitable model system for the study of glucose and nutrient regulation of insulin secretion and biosynthesis. This would serve as a basis for investigating the GLP-1 effects on pancreatic b-cell biology. This thesis shows that two b-cell model systems, namely MIN6 and INS-1 cells, respond to increasing concentrations of glucose, by increasing insulin secretion and cell proliferation in a physiological manner. The MIN6 cell line also responds to other cellular nutrients, L-arginine and L-leucine in a manner similar to primary islet cells. The MIN6 cel

APA, Harvard, Vancouver, ISO, and other styles

12

Wong, Lisa Catherine. "Immunomodulatory effects of synthetic peptide IDR-1018 in human keratinocytes." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/43902.

Full text

Abstract:

The diverse immunomodulatory properties of naturally occurring host defence peptides have gained prominence over the past decade. There is large interest in creating small synthetic peptides with similar or enhanced immunomodulatory activities. The epithelia are vital components of the human innate immune system, offering protection against potential pathogens by acting as a physical barrier and actively participating in the immune response. The aim of this study was to examine the direct effects of synthetic host defence peptides on the immune response in keratinocytes, the primary cell type

APA, Harvard, Vancouver, ISO, and other styles

13

Barker, Ellen. "Investigating the effects of Zeta Inhibitory Peptide on AMPAR trafficking." Thesis, University of Bristol, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.628992.

Full text

Abstract:

In recent years, several studies have suggested a role for PKMs, an atypical isoform of PKC, in memory consolidation and long-term potentiation (LTP). Some evidence in support of this theory has come to light, in the form of electrophysiological and behavioural studies, using inhibition, knockdown, perfusion of the molecule itself and overexpression. Exogenously applying the PKM~ to systems leads to potentiation. Conversely, application of Zeta Inhibitory Peptide (ZIP), a peptide sequence purported to inhibit PKMs, consistently reverses LTP and in most cases, erases memories. To date, however,

APA, Harvard, Vancouver, ISO, and other styles

14

Nakao, Kazumasa. "The effects of C-type natriuretic peptide on craniofacial skeletogenesis." Kyoto University, 2013. http://hdl.handle.net/2433/174773.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Hansell, D. J. "Action of ACTH peptides on the adrenal gland." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233492.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Haws, C. "Studies on pro-opiomelanocortin peptide-containing neuronal pathways in the rat brain." Thesis, University of Leeds, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378896.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Harris, Mark R. "Effects of cationic antimicrobial peptides on Candida and Saccharomyces species." Thesis, St Andrews, 2010. http://hdl.handle.net/10023/881.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

吳勝前 and Shengqian Wu. "Study of atrial natriuretic peptide and endothelin in streptozotocin-diabetic rats and in the aging rats." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31237885.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Zhu, Donghui. "Effects of oxidative stress and Alzheimer's amyloid-beta peptide on astrocytes." Diss., Columbia, Mo. : University of Missouri-Columbia, 2006. http://hdl.handle.net/10355/5900.

Full text

Abstract:

Thesis (Ph. D.)--University of Missouri-Columbia, 2006.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file viewed on (March 3, 2007) Vita. Includes bibliographical references.

APA, Harvard, Vancouver, ISO, and other styles

20

Samnegård, Björn. "Renal effects of C-peptide in experimental type-1 diabetes mellitus /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-502-X/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Källner, Göran. "Release and effects of calcitonin gene-related peptide in myocardial ischaemia /." Oslo ; Stockholm : Scandinavian Univ. Press, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980911kall.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Fu, Chunjiang. "Peptide requirement of ruminal microbes and its effects on animal performance /." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9999283.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Janssen, Wilbert Martien Theodoor. "Atrial natriuretic factor integrated effects on blood pressure, natriuresis, and renal medullary blood flow in man /." [S.l. : [Groningen] : s.n.] ; [University Library Groningen] [Host], 1994. http://irs.ub.rug.nl/ppn/123950805.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Breci, Linda Anne. "The effects of conformation and N-alkylation on gas phase peptide fragmentation." Diss., The University of Arizona, 2001. http://hdl.handle.net/10150/289755.

Full text

Abstract:

Investigations described in this dissertation found that cleavage at Xxx-Pro bonds depends upon the identity of the Xxx residue, and this finding is immediately applicable to improved peptide sequencing algorithms because enhanced cleavage was evident for Pro-containing peptides when Xxx is His, Asp, Val, Ile, or Leu, and reduced cleavage was evident when Xxx is Gly or Pro. A greater understanding of the mechanism of cleavage at Pro residues was gained in these studies. A non-Pro N-alkylated residue in a peptide directs cleavage C-terminal to the N-alkylated residue; this is dependent upon the

APA, Harvard, Vancouver, ISO, and other styles

25

Ojo, Bunmi. "Effects of the NCAM-derived peptide, FGL, in the aged rat hippocampus." Thesis, Open University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539423.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Baker, Keren Julie. "Effects of peptide toxins on the Ca'2'+-ATPase of sarcoplasmic reticulum." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296260.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Hasler, Loretta. "Blood levels and renal effects of atrial natriuretic peptide in normal man /." [S.l : s.n.], 1985. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Giblett, Joel Peter. "Cardioprotective effects of Glucagon-like Peptide 1 (GLP-1) and their mechanisms." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/263201.

Full text

Abstract:

Background: Glucagon-like Peptide 1 (GLP-1) is a human incretin hormone that has been demonstrated to protect against non-lethal ischaemia reperfusion injury in the left ventricle in humans. It has been suggested from some animal research that this protection may be mediated through the pathway of ischaemic conditioning, of which the opening of the mKATP channel is a key step. Furthermore, it is uncertain whether the protection applies to the right ventricle. Finally, there is limited human evidence of a protective effect against lethal ischaemia reperfusion injury. Methods: Two studies use no

APA, Harvard, Vancouver, ISO, and other styles

29

Capan, Colt Dylan. "Effects of SOCS1 and SOCS3 Peptide Mimetics on MacrophagePhagocytosis of Malignant Cells." Wright State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=wright1501263743238988.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Pathak, Nupur Madhur. "Effects of novel peptide therapeutics and epigallocatechin on diabetes and cognitive dysfunction." Thesis, Ulster University, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.706477.

Full text

Abstract:

The prevalence of type 2 diabetes (T2DM) has increased alarmingly in the past two decades. In addition, there is now a strong link between cognitive impairment and T2DM. This not only highlights the pharmacologic shortcomings of current therapies, but also demonstrates the imperative need to develop novel therapeutics that can address T2DM associated complications including cognitive and hippocampal dysfunctions. In this regard, proglucagon derived hormones, especially GLP-1 mimetics, have received much attention in the recent past. Therefore, this thesis has evaluated the actions of novel pro

APA, Harvard, Vancouver, ISO, and other styles

31

Wang, Yong [Verfasser]. "Cardiovascular effects of C-type natriuretic peptide (CNP) overexpression in transgenic animals / Yong Wang." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2008. http://d-nb.info/1022870246/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Mughal, Romana Saher. "In vitro effects of insulin and proinsulin C-peptide on human saphenous vein function." Thesis, University of Leeds, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539686.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Frankot, Michelle. "The Effects of a High-Energy Diet, Fasting, and Peptide Signaling on Ingestive Behavior." Thesis, California State University, Long Beach, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10839575.

Full text

Abstract:

<p> Alternate day fasting (ADF) leads to weight loss in humans and rats. To examine the effects of ADF on diet preference, rats were assigned to alternate day or free food access and presented with chow and high-energy (HE) food. Satiety peptides CCK and exendin-4 were administered to determine if they altered the relationship between fasting and preference. Fasting decreased HE preference compared to controls. For males, this was driven by an increase in size and number of chow meals. For females, this was driven by an increase in chow meal number. ADF appeared to increase orosensory stimulat

APA, Harvard, Vancouver, ISO, and other styles

34

Madkhali, Tahirah M. "The Effects of SOCS1 and SOCS3 Peptide Mimetics on Macrophage Phagocytosis of Malignant Cells." Wright State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wright1557480896176185.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Pereira, Marie. "Skeletal effects and signalling mechanisms of glucagon-like peptide-1 receptor agonists in bone." Thesis, Royal Veterinary College (University of London), 2017. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.731289.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Filewod, Niall Christopher Jack. "Immunomodulatory effects of LL-37 in the epithelia." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/927.

Full text

Abstract:

The cationic host defence peptide LL-37 is an immunomodulatory agent that plays an important role in epithelial innate immunity. Previously, concentrations of LL-37 thought to represent levels present during inflammation have been shown to elicit the production of cytokines and chemokines by epithelial cells. To investigate the potential of lower concentrations of LL-37 to alter epithelial cell responses, normal primary keratinocytes and bronchial epithelial cells were treated with pro-inflammatory stimuli in the presence or absence of 1 – 3 μg/ml LL-37. Low, physiologically relevant concentra

APA, Harvard, Vancouver, ISO, and other styles

37

Smillie, Sarah-Jane. "Pathophysiological effects of calcitonin gene-related peptide in a model of cardiovascular dysfunction and remodelling." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/pathophysiological-effects-of-calcitonin-generelated-peptide-in-a-model-of-cardiovascular-dysfunction-and-remodelling(49609c8c-f884-45fa-819b-19abc26fbb8d).html.

Full text

Abstract:

Hypertension is the number one killer in the Western world at present and is a major risk factor for the development of cardiovascular disease. However, despite the extensive range of therapies, the mechanisms involved in its onset still remain unclear, therefore there is a need to investigate the mechanisms involved. Calcitonin gene-related peptide (CGRP) is best known as a sensory nerve-derived neuropeptide, a potent microvascular vasodilator and is suggested to be protective in a range of models of hypertension. The aim of this study was to investigate the influence of CGRP on vascular mech

APA, Harvard, Vancouver, ISO, and other styles

38

Kamino, Daphne. "Effects of LTD-blocking Tat-GluR2 Peptide on Contextual Fear Memory Impairments Induced by Cannabinoids." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23172.

Full text

Abstract:

The mechanisms underlying cannabinoid impairment of fear memory is not clear. This study investigated the effects of the synthetic cannabinoid HU210 and the endocannabinoid hydrolysis inhibitor JZL 195 on fear memory following contextual fear conditioning (CFC; an animal model of fear). The long-term depression (LTD)-blocking peptide Tat-GluR2 was utilized to investigate whether the expression of cannabinoid-induced LTD (CB-LTD) is required for the cannabinoid impairment of acquisition and consolidation of contextual fear memory. HU210 reduced freezing throughout the test phase of the acqui

APA, Harvard, Vancouver, ISO, and other styles

39

Emmett, Stevan Richard. "Non-classical effects of acetylcholinesterase and related peptide fragments on neurochemical regulation in the midbrain." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365712.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

King, James A. "Effects of exercise on appetite, food intake and the gastrointestinal hormones Ghrelin and Peptide YY." Thesis, Loughborough University, 2010. https://dspace.lboro.ac.uk/2134/7101.

Full text

Abstract:

Gut hormones are implicated in the regulation of energy balance. The studies in this thesis have examined the effects exercise on gut hormones (acylated ghrelin and peptide YY3-36), appetite and food intake, over extended durations. Sixty-nine young, healthy, predominantly Caucasian males were recruited to six studies. The age, height and body mass of the participants were: 22.4 ± 0.3 y, 1.80 ± 0.1 m, 76.2 ± 1.0 kg (mean ± SEM). In study one, 90 min of resistance exercise did not influence appetite or energy intake over 24 h of assessment, yet stimulated a latent preference for carbohydrate ri

APA, Harvard, Vancouver, ISO, and other styles

41

Mabrouk, Mabrouk Mohamed. "Behavioural effects and neurochemical studies of a novel thyrotrophin-releasing hormone (TRH)-like peptide (FPP)." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339688.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Patel, Shailendra. "Central nervous system actions of the peptide galanin : effects on cholinergic and serotoninergic neural function." Thesis, University of Hertfordshire, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245450.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Chow, Siu Kei. "The associated effects of Alzheimer's amyloid-[beta]-peptide and disrupted calcium homeostasis on reactive astrogliosis." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p1457310.

Full text

Abstract:

Thesis (M.S.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed November 5, 2008). Available via ProQuest Digital Dissertations. Includes bibliographical references (p. 36-47).

APA, Harvard, Vancouver, ISO, and other styles

44

Kisiday, John D. (John David) 1970. "In vitro culture of a chondrocyte-seeded peptide hydrogel and the effects of dynamic compression." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/29614.

Full text

Abstract:

Thesis (Ph. D. in Bioengineering)--Massachusetts Institute of Technology, Biological Engineering Division, 2003.<br>Includes bibliographical references.<br>Emerging medical technologies for effective and lasting repair of articular cartilage include delivery of cells or cell-seeded scaffolds to a defect site to initiate de novo tissue regeneration. Biocompatible scaffolds assist in providing a template for cell distribution and extracellular matrix accumulation in a three-dimensional geometry. In these studies, a self-assembling peptide hydrogel is evaluated as a potential scaffold for cartila

APA, Harvard, Vancouver, ISO, and other styles

45

Allan, Laura Elizabeth. "Investigating the effects of the Alzheimer's disease-associated amyloid β-peptide on intracellular calcium homeostasis". Thesis, University of Cambridge, 2010. https://www.repository.cam.ac.uk/handle/1810/283857.

Full text

Abstract:

I investigated the effects of Aβ<sub>42</sub> on the Ca<sup>2+</sup> signalling capacity of human neuroblastoma SH-SY5Y cells and primary hippocampal cultures. I developed an <i>in vitro</i> model system of dissociated hippocampal neurons and glial cells in order to reflect as closely as possible the mature hippocampus. Extensive characterisation of the culture revealed that functional neuronal networks were established by day <i>in vitro </i>11, as demonstrated by the occurrence of spontaneous oscillations in both membrane potential and intracellular Ca<sup>2+</sup> levels. Neurons exhibited

APA, Harvard, Vancouver, ISO, and other styles

46

Broom, David R. "The effects of exercise on hunger and the hunger-related hormones ghrelin and peptide YY." Thesis, Loughborough University, 2008. https://dspace.lboro.ac.uk/2134/34049.

Full text

Abstract:

Aerobic and resistance exercise have been promoted as a key component of exercise recommendations for weight control because exercise is an effective method of increasing energy expenditure and it may paradoxically, lead to a short-term hunger suppression. This phenomenon has been termed 'exercise induced anorexia' but the mechanisms are unclear so the relationship between exercise and hunger has led to a need for investigators to study the role of gut hormones in mediating exercise-induced hunger changes. The effect of acute exercise bouts on total plasma ghrelin concentrations is controversi

APA, Harvard, Vancouver, ISO, and other styles

47

Fitzgerald, C. P. "Development of bioactive bread enriched with a seaweed peptide fraction with potential heart-health effects." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1430955/.

Full text

Abstract:

Cardiovascular disease (CVD) is currently a global epidemic and is now the leading cause of mortality worldwide. The two major approaches for the prevention of CVD in the developed world are public health based Policies and clinical based Strategies focusing on high-risk individuals. Pharmaceutical companies have developed a range of treatments to tackle the causes of CVD and these include the development of anti-inflammatory, anti-hypertensive and anti-cholesterol drugs. However, unpleasant side-effects often exist with prescription drug-taking. Sourcing of natural food components from foods

APA, Harvard, Vancouver, ISO, and other styles

48

Raddant, Ann Christine. "Regulation of CGRP gene expression and effects on light aversive behavior." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/2000.

Full text

Abstract:

Migraine is a debilitating neurological disorder, which affects over 10% of the general population. In addition to headache, migraine includes a host of associated symptoms, such as nausea and hypersensitivity to light, noise, and touch. While great strides have been made in migraine treatment in recent decades, the basic biological and pathophysiological mechanisms underlying migraine are still not well understood. Pain signals travel via a polysynaptic pathway from the periphery to the cortex, whe

APA, Harvard, Vancouver, ISO, and other styles

49

Kopesky, Paul Wayne. "Self-assembling peptide hydrogels promote in vitro chondrogenesis of bone marrow-derived stromal cells : effects of peptide sequence, cell donor age, and method of growth factor delivery." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/61225.

Full text

Abstract:

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biological Engineering, 2009.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 108-115).<br>The inability of articular cartilage to heal after damage or disease has motivated investigation of novel cartilage tissue engineering technologies. The objective of this thesis was to advance the use of self-assembling peptide hydrogel scaffolds for cartilage repair by encapsulating bone-marrow-stromal cells (BMSCs) and incorporating chondrogenic cues to stimulate differentiation and neotissue production

APA, Harvard, Vancouver, ISO, and other styles

50

Taufiq, Samia. "Establishment of a mouse model of colitis and its use to evaluate the anti-inflammatory effects of two ghrelin peptides." Queensland University of Technology, 2009. http://eprints.qut.edu.au/29261/.

Full text

Abstract:

Ghrelin is a gut-brain peptide hormone that induces appetite, stimulates the release of growth hormone, and has recently been shown to ameliorate inflammation. Recent studies have suggested that ghrelin may play a potential role in inflammation-related diseases such as inflammatory bowel diseases (IBD). A previous study with ghrelin in the TNBS mouse model of colitis demonstrated that ghrelin treatment decreased the clinical severity of colitis and inflammation and prevented the recurrence of disease. Ghrelin may be acting at the immunological and epithelial level as the ghrelin receptor (GHSR

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!