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Journal articles on the topic 'Peptide effects'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

NEVALAINEN, Leena T., Takashi AOYAMA, Mitsuhiko IKURA, et al. "Characterization of novel calmodulin-binding peptides with distinct inhibitory effects on calmodulin-dependent enzymes." Biochemical Journal 321, no. 1 (1997): 107–15. http://dx.doi.org/10.1042/bj3210107.

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We describe the isolation and interaction with calmodulin (CaM) of two 10-amino-acid peptides (termed peptides 1 and 2; AWDTVRISFG and AWPSLQAIRG respectively) derived from a phage random peptide display library. Both peptides are shorter than previously described CaM-binding peptides and lack certain features found in the sequences of CaM-binding domains present in CaM-activated enzymes. However, 1H NMR spectroscopy and fluorimetry indicate that both peptides interact with CaM in the presence of Ca2+. The two peptides differentially inhibited CaM-dependent kinases I and II (CaM kinases I and

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2

Srivastava, Mrinal Ranjan, Farzana Mahdi, Abbas Ali Mahdi, Sharique Ahmad, and Anu Chandra. "BIOLOGICAL EFFECTS OF C-PEPTIDE AND PROINSULIN: WE JIBE TOGETHER." Era's Journal of Medical Research 6, no. 1 (2019): 103–9. http://dx.doi.org/10.24041/ejmr2019.115.

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3

Lorenzón, E. N., G. F. Cespedes, E. F. Vicente, et al. "Effects of Dimerization on the Structure and Biological Activity of Antimicrobial Peptide Ctx-Ha." Antimicrobial Agents and Chemotherapy 56, no. 6 (2012): 3004–10. http://dx.doi.org/10.1128/aac.06262-11.

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ABSTRACTIt is well known that cationic antimicrobial peptides (cAMPs) are potential microbicidal agents for the increasing problem of antimicrobial resistance. However, the physicochemical properties of each peptide need to be optimized for clinical use. To evaluate the effects of dimerization on the structure and biological activity of the antimicrobial peptide Ctx-Ha, we have synthesized the monomeric and three dimeric (Lys-branched) forms of the Ctx-Ha peptide by solid-phase peptide synthesis using a combination of 9-fluorenylmethyloxycarbonyl (Fmoc) andt-butoxycarbonyl (Boc) chemical appro

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4

Wigle, D. A., B. M. Bennett, D. B. Jennings, I. R. Sarda, T. G. Flynn, and S. C. Pang. "Biological effects of rat iso-atrial natriuretic peptide and brain natriuretic peptide are indistinguishable from each other." Canadian Journal of Physiology and Pharmacology 70, no. 11 (1992): 1525–28. http://dx.doi.org/10.1139/y92-218.

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Rat brain natriuretic peptide (rBNP) and iso-atrial natriuretic peptide (iso-rANP) were discovered independently by two research laboratories. They are considered to be members of the B-type natriuretic peptides. Except for the Gln/Leu substitution at position 44, the amino acid sequence of iso-rANP is identical with that of the C-terminal 45 amino acids of rat pro-BNP and with the 5-kDa cardiac peptide from rat atria. To determine whether this amino acid substitution can modify the known biological effects of rBNP and iso-rANP, the present investigation examined the cardiovascular and renal r

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Ano, Yasuhisa, Yuka Yoshino, Kazuyuki Uchida, and Hiroyuki Nakayama. "Preventive Effects of Tryptophan–Methionine Dipeptide on Neural Inflammation and Alzheimer’s Pathology." International Journal of Molecular Sciences 20, no. 13 (2019): 3206. http://dx.doi.org/10.3390/ijms20133206.

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Preventive approaches for age-related memory decline and dementia have become a high priority in the aging society because of the lack of therapeutic approaches. Recent epidemiological studies have reported that fermented dairy products can help prevent dementia. Previously, we identified tryptophan–tyrosine (WY) and tryptophan–methionine (WM) peptides as the suppressants of activation of the primary microglia and showed that WY peptide consumption suppresses inflammation in the brains of Alzheimer’s disease model mice. However, the effects of the WM peptide on inflammation in the brain and Al

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Nongonierma, Alice B., and Richard J. FitzGerald. "Utilisation of the isobole methodology to study dietary peptide–drug and peptide–peptide interactive effects on dipeptidyl peptidase IV (DPP-IV) inhibition." Food & Function 6, no. 1 (2015): 312–19. http://dx.doi.org/10.1039/c4fo00883a.

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7

Chauhan, Sweeny, Sean O’Callaghan, Audrey Wall, et al. "Using Peptidomics and Machine Learning to Assess Effects of Drying Processes on the Peptide Profile within a Functional Ingredient." Processes 9, no. 3 (2021): 425. http://dx.doi.org/10.3390/pr9030425.

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Bioactive peptides are known to have many health benefits beyond nutrition; yet the peptide profile of high protein ingredients has been largely overlooked when considering the effects of different processing techniques. Therefore, to investigate whether drying conditions could affect the peptide profile and bioactivity within a functional ingredient, we examined the effects of spray (SD) and freeze (FD) drying on rice natural peptide network (NPN), a characterised functional ingredient sourced from the Oryza sativa proteome, which has previously been shown to effectively modulate circulating

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8

Hayes, Maria. "Bioactive Peptides in Preventative Healthcare: An Overview of Bioactivities and Suggested Methods to Assess Potential Applications." Current Pharmaceutical Design 27, no. 11 (2021): 1332–41. http://dx.doi.org/10.2174/1381612827666210125155048.

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Food derived bioactive peptides can be generated from various protein sources and usually consist of between 2-30 amino acids with bulky, side-chain aromatic amino acids preferred in the ultimate and penultimate positions at the C-terminal end of the amino acid chain. They are reported to impart a myriad of preventative health beneficial effects to the consumer once ingested and these include heart health benefits through inhibition of enzymes including renin (EC 3.4.23.15) and angiotensin- I-converting enzyme (ACE-1; EC 3.4.15.1) within the renin angiotensin aldosterone system (RAAS) anti-inf

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9

Burkitt, William I., Anastassios E. Giannakopulos, Foteini Sideridou, Sajid Bashir, and Peter J. Derrick. "Discrimination Effects in MALDI-MS of Mixtures of Peptides—Analysis of the Proteome." Australian Journal of Chemistry 56, no. 5 (2003): 369. http://dx.doi.org/10.1071/ch02155.

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Peptide ion suppression in matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) can hinder the detection of site-specific post-translational protein modifications. Within a peptide mixture, the presence or absence of a particular peptide can affect the ion intensities of other peptides in the mixture. These effects have been studied using equimolar solutions of target peptides and observation of the increase or decrease in ion intensity of the peptides upon the removal or addition of individual peptides. Gas-phase basicities and hydrophobicity measures have been used to rat

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10

Li, Mingjie, Eric Sanchez, Jennifer Li, et al. "TRAF6-Dominant Negative Peptides Show Potent Inhibitory Effects On Multiple Myeloma, Osteoclast Formation and Bone Resorption." Blood 114, no. 22 (2009): 611. http://dx.doi.org/10.1182/blood.v114.22.611.611.

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Abstract Abstract 611 Tumor necrosis factor receptor-associated factor 6 (TRAF6) has been implicated in regulating NF-κB and JNK signal transduction pathway resulting in inhibition of tumor cell proliferation and osteoclast formation. The unique biological function of TRAF6 is largely determined within its TRAF-C domain which does not interact with peptide motifs that are recognized by other TRAFs including 1, 2, 3 or 5. We have recently reported inhibition of cell proliferation and increased apoptosis of multiple myeloma (MM) cells through regulation of the NF-κB and JNK pathways through sile

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11

VILLA, Giorgio LA, Massimo MANNELLI, Chiara LAZZERI, et al. "Different effects of atrial and C-type natriuretic peptide on the urinary excretion of endothelin-1 in man." Clinical Science 95, no. 5 (1998): 595–602. http://dx.doi.org/10.1042/cs0950595.

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1.Following the observation that brain natriuretic peptide enhances the urinary excretion rate of endothelin-1, the relationship between natriuretic peptides and urinary endothelin-1 was further investigated. Six healthy volunteers received, on three different occasions, increasing doses of atrial or C-type natriuretic peptide (0, 2 and 4 ;pmol·min-1·kg-1 for 1 ;h each), or placebo. 2.Atrial natriuretic peptide caused significant increases in the urinary excretion of cGMP, sodium and endothelin-1, without affecting plasma endothelin-1, renal plasma flow, glomerular filtration rate and urine fl

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12

Drazen, J. M., S. A. Shore, and N. P. Gerard. "Substance P-induced effects in guinea pig lungs: effects of thiorphan and captopril." Journal of Applied Physiology 66, no. 3 (1989): 1364–72. http://dx.doi.org/10.1152/jappl.1989.66.3.1364.

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The effects of the neutral metalloendopeptidase inhibitor, thiorphan, and the angiotensin-converting enzyme inhibitor, captopril, on the changes in airway opening pressure (PaO), pulmonary arterial pressure (Ppa), and weight induced by intravascular administration of substance P were examined in isolated perfused and ventilated guinea pig lungs. Administration of 1 nmol substance P without enzyme inhibitors resulted in a significant (P less than 0.01) increase in the peak PaO during ventilation from 12.4 +/- 0.5 to 22.4 +/- 2.2 cmH2O; there were small statistically insignificant increases in P

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13

Forte, Madonna, Schiavon, et al. "Cardiovascular Pleiotropic Effects of Natriuretic Peptides." International Journal of Molecular Sciences 20, no. 16 (2019): 3874. http://dx.doi.org/10.3390/ijms20163874.

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Atrial natriuretic peptide (ANP) is a cardiac hormone belonging to the family of natriuretic peptides (NPs). ANP exerts diuretic, natriuretic, and vasodilatory effects that contribute to maintain water–salt balance and regulate blood pressure. Besides these systemic properties, ANP displays important pleiotropic effects in the heart and in the vascular system that are independent of blood pressure regulation. These functions occur through autocrine and paracrine mechanisms. Previous works examining the cardiac phenotype of loss-of-function mouse models of ANP signaling showed that both mice wi

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14

Ichimura, Keiichi, Hiroyuki Mineda, and Atsuro Seki. "Vascular Effects of Neuropeptides on Nasal Mucosa." Annals of Otology, Rhinology & Laryngology 97, no. 3 (1988): 289–93. http://dx.doi.org/10.1177/000348948809700316.

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We used dog nasal blood vessels and an in vitro muscle tension-detecting technique to examine the vascular effects of several neuropeptides: Vasoactive intestinal polypeptide, substance P, neurotensin, somatostatin, and neuropeptide Y (NPY). Electrically induced vasoconstriction was inhibited by every peptide except neurotensin, which enhanced this response. Every preparation treated with somatostatin, and one tissue treated with NPY, showed an enhanced noradrenaline-induced contraction. Only NPY caused a tissue contraction. Preparations precontracted by methoxamine were relaxed by every pepti

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15

Akagi, Keiko, Taku Nagao та Tetsuro Urushidani. "Responsiveness of β-escin-permeabilized rabbit gastric gland model: effects of functional peptide fragments". American Journal of Physiology-Gastrointestinal and Liver Physiology 277, № 3 (1999): G736—G744. http://dx.doi.org/10.1152/ajpgi.1999.277.3.g736.

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We established a β-escin-permeabilized gland model with the use of rabbit isolated gastric glands. The glands retained an ability to secrete acid, monitored by [14C]aminopyrine accumulation, in response to cAMP, forskolin, and histamine. These responses were all inhibited by cAMP-dependent protein kinase inhibitory peptide. Myosin light-chain kinase inhibitory peptide also suppressed aminopyrine accumulation, whereas the inhibitory peptide of protein kinase C or that of calmodulin kinase II was without effect. Guanosine-5′- O-(3-thiotriphosphate) (GTPγS) abolished cAMP-stimulated acid secretio

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16

Armas, Federica, Adriana Di Stasi, Mario Mardirossian, Antonello A. Romani, Monica Benincasa, and Marco Scocchi. "Effects of Lipidation on a Proline-Rich Antibacterial Peptide." International Journal of Molecular Sciences 22, no. 15 (2021): 7959. http://dx.doi.org/10.3390/ijms22157959.

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The emergence of multidrug-resistant bacteria is a worldwide health problem. Antimicrobial peptides have been recognized as potential alternatives to conventional antibiotics, but still require optimization. The proline-rich antimicrobial peptide Bac7(1-16) is active against only a limited number of Gram-negative bacteria. It kills bacteria by inhibiting protein synthesis after its internalization, which is mainly supported by the bacterial transporter SbmA. In this study, we tested two different lipidated forms of Bac7(1-16) with the aim of extending its activity against those bacterial speci

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17

Li, Yue, Zhenghua Tang, Paras N. Prasad, Marc R. Knecht, and Mark T. Swihart. "Peptide-mediated synthesis of gold nanoparticles: effects of peptide sequence and nature of binding on physicochemical properties." Nanoscale 6, no. 6 (2014): 3165–72. http://dx.doi.org/10.1039/c3nr06201e.

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18

Gargosky, S. E., J. C. Wallace, F. M. Upton, and F. J. Ballard. "C-terminal bombesin sequence requirements for binding and effects on protein synthesis in Swiss 3T3 cells." Biochemical Journal 247, no. 2 (1987): 427–32. http://dx.doi.org/10.1042/bj2470427.

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1. Synthetic peptides corresponding to the five, seven, nine and eleven C-terminal amino acids of the tetradecapeptide bombesin as well as bombesin itself and gastrin-releasing peptide have been evaluated in Swiss 3T3 cells in order to define the minimal peptide length needed for biological responsiveness. 2. Gastrin-releasing peptide, bombesin, the undecapeptide and nonapeptide had nearly equipotent abilities to compete for binding of labelled gastrin-releasing peptide to the cell receptors and showed half-maximal competition at 5-10 nM. The heptapeptide and pentapeptide were ineffective. 3.

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19

Fernandes, Eduardo F. A., Linda M. Haugaard-Kedström, and Kristian Strømgaard. "The Effects of Lipidation on a TAT-Containing Peptide-Based Inhibitor of PSD-95." Australian Journal of Chemistry 73, no. 4 (2020): 307. http://dx.doi.org/10.1071/ch19392.

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Stability and cell permeability are critical parameters in the development of peptide therapeutics. Conjugation to fatty acids and cell-penetrating peptides, such as TAT (YGRKKRRQRRR), are established strategies to increase peptide stability and permeation, respectively. Here, we prepared lipidated analogues of a potent TAT-containing dimeric peptide-based inhibitor of the intracellular scaffolding protein PSD-95, an emerging drug target in ischaemic stroke. Lipidation increased peptide stability in vitro and in vivo. Combining both lipidation and conjugation to TAT improved brain/plasma ratio

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20

Shabab, Mohammed, Markus F. F. Arnold, Jon Penterman, et al. "Disulfide cross-linking influences symbiotic activities of nodule peptide NCR247." Proceedings of the National Academy of Sciences 113, no. 36 (2016): 10157–62. http://dx.doi.org/10.1073/pnas.1610724113.

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Interactions of rhizobia with legumes establish the chronic intracellular infection that underlies symbiosis. Within nodules of inverted repeat-lacking clade (IRLC) legumes, rhizobia differentiate into nitrogen-fixing bacteroids. This terminal differentiation is driven by host nodule-specific cysteine-rich (NCR) peptides that orchestrate the adaptation of free-living bacteria into intracellular residents. Medicago truncatula encodes a family of >700 NCR peptides that have conserved cysteine motifs. NCR247 is a cationic peptide with four cysteines that can form two intramolecular disulfide b

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21

Cozza, Eduardo N., Mark F. Foecking, Maria del Carmen Vila, and Celso E. Gomez-Sanchez. "Adrenal receptors for natriuretic peptides and inhibition of aldosterone secretion in calf zona glomerulosa cells in culture." Acta Endocrinologica 129, no. 1 (1993): 59–64. http://dx.doi.org/10.1530/acta.0.1290059.

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Atrial and brain natriuretic peptides specifically bind to primary cultures of calf adrenal glomerulosa cells. Binding of both natriuretic peptides to the same receptor has been proved by: a Dixon plot showing competitive effects for the binding of 125I-labeled brain natriuretic peptide in the presence of increasing concentrations of unlabeled atrial natriuretic peptide; a Scatchard plot showing a lower dissociation constant (Kd) for atrial natriuretic peptide than for brain natriuretic peptide binding, but the maximum binding (Bmax) values were the same; autoradiography of sodium dodecyl sulf

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22

Nordström, Randi, Lina Nyström, Humaira Ilyas, et al. "Microgels as carriers of antimicrobial peptides – Effects of peptide PEGylation." Colloids and Surfaces A: Physicochemical and Engineering Aspects 565 (March 2019): 8–15. http://dx.doi.org/10.1016/j.colsurfa.2018.12.049.

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23

MAGEE, COLM C., HARUHITO AZUMA, ANDREAS KNOFLACH, et al. "In Vitro and in Vivo Immunomodulatory Effects of RDP1258, a Novel Synthetic Peptide." Journal of the American Society of Nephrology 10, no. 9 (1999): 1997–2005. http://dx.doi.org/10.1681/asn.v1091997.

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Abstract. Peptides derived from certain regions of human class I MHC molecules are known to have immunomodulatory effects. In particular, amino acid residues 75-84 of the HLA-B7 and HLA-B2702 molecules have demonstrated allele nonspecific immunosuppression in several animal transplant models. There is evidence that these effects are mediated by binding to intracellular heat shock proteins, including heme oxygenase-1. A new derivative of these peptides, RDP1258, was developed using a novel computer-assisted rational design technique. In vitro, RDP1258 peptide inhibited rat heme oxygenase activi

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Solarte, Víctor A., Jaiver E. Rosas, Zuly J. Rivera, Martha L. Arango-Rodríguez, Javier E. García, and Jean-Paul Vernot. "A Tetrameric Peptide Derived from Bovine Lactoferricin Exhibits Specific Cytotoxic Effects against Oral Squamous-Cell Carcinoma Cell Lines." BioMed Research International 2015 (2015): 1–13. http://dx.doi.org/10.1155/2015/630179.

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Several short linear peptides derived from cyclic bovine lactoferricin were synthesized and tested for their cytotoxic effect against the oral cavity squamous-cell carcinoma (OSCC) cell lines CAL27 and SCC15. As a control, an immortalized and nontumorigenic cell line, Het-1A, was used. Linear peptides based on the RRWQWR core sequence showed a moderate cytotoxic effect and specificity towards tumorigenic cells. A tetrameric peptide, LfcinB(20–25)4, containing the RRWQWR motif, exhibited greater cytotoxic activity (>90%) in both OSCC cell lines compared to the linear lactoferricin peptide or

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25

Richards, Jennifer P., Alan H. Stephenson, Mary L. Ellsworth, and Randy S. Sprague. "Synergistic effects of C-peptide and insulin on low O2-induced ATP release from human erythrocytes." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 305, no. 11 (2013): R1331—R1336. http://dx.doi.org/10.1152/ajpregu.00341.2013.

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Erythrocytes participate in the matching of oxygen (O2) delivery with local need in skeletal muscle via the release of O2and the vasodilator, ATP. It was reported that a concentration of insulin found in humans with insulin resistance inhibits low O2-induced ATP release. However, in vivo, insulin is coreleased with connecting peptide (C-peptide) at equimolar concentrations, but because of the shorter insulin half-life, the peptides circulate at ratios of C-peptide to insulin ranging from 1:1 to 6:1. Here, we investigate the hypothesis that C-peptide and insulin work synergistically to maintain

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Alcaide-Hidalgo, Juan María, Miguel Romero, Juan Duarte, and Eduardo López-Huertas. "Antihypertensive Effects of Virgin Olive Oil (Unfiltered) Low Molecular Weight Peptides with ACE Inhibitory Activity in Spontaneously Hypertensive Rats." Nutrients 12, no. 1 (2020): 271. http://dx.doi.org/10.3390/nu12010271.

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The low molecular weight peptide composition of virgin olive oil (VOO) is mostly unknown. We hypothesised that unfiltered VOO could possess low molecular weight peptides with antihypertensive activity. We produced unfiltered VOO and obtained a water-soluble peptide extract from it. The peptides were separated by size-exclusion using fast protein liquid chromatography, and the low molecular weight fraction was analysed by nanoscale liquid chromatography-Orbitrap coupled with tandem mass spectrometry and de novo sequencing. We selected 23 peptide sequences containing between 6 and 9 amino acids

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RUISSEN, Anita L. A., Jasper GROENINK, Eva J. HELMERHORST, et al. "Effects of histatin 5 and derived peptides on Candida albicans." Biochemical Journal 356, no. 2 (2001): 361–68. http://dx.doi.org/10.1042/bj3560361.

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Three anti-microbial peptides were compared with respect to their killing activity against Candida albicans and their ability to disturb its cellular and internal membranes. Histatin 5 is an anti-fungal peptide occurring naturally in human saliva, while dhvar4 and dhvar5 are variants of its active domain, with increased anti-microbial activity. dhvar4has increased amphipathicity compared with histatin 5, whereas dhvar5has amphipathicity comparable with that of histatin 5. All three peptides caused depolarization of the cytoplasmic and/or mitochondrial membrane, indicating membranolytic activit

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Hou, Shuyu, Zhigang Liu, Anne W. Young, Sheron L. Mark, Neville R. Kallenbach, and Dacheng Ren. "Effects of Trp- and Arg-Containing Antimicrobial-Peptide Structure on Inhibition of Escherichia coli Planktonic Growth and Biofilm Formation." Applied and Environmental Microbiology 76, no. 6 (2010): 1967–74. http://dx.doi.org/10.1128/aem.02321-09.

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ABSTRACT Biofilms are sessile microbial communities that cause serious chronic infections with high morbidity and mortality. In order to develop more effective approaches for biofilm control, a series of linear cationic antimicrobial peptides (AMPs) with various arginine (Arg or R) and tryptophan (Trp or W) repeats [(RW) n -NH2, where n = 2, 3, or 4] were rigorously compared to correlate their structures with antimicrobial activities affecting the planktonic growth and biofilm formation of Escherichia coli. The chain length of AMPs appears to be important for inhibition of bacterial planktonic

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29

Mohri, Hiroshi, та Takao Ohkubo. "Effects of Hybrid Peptide Analogs to Receptor Recognition Domains on α- and γ-Chains of Human Fibrinogen on Fibrinogen Binding to Platelets". Thrombosis and Haemostasis 69, № 05 (1993): 490–95. http://dx.doi.org/10.1055/s-0038-1651639.

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SummaryWe synthesized a series of hybrid peptides that correspond to the γ-chain dodecapeptide (400-411), variable numbers of glycine residues, and the RGDS peptide [Y-HHLGGAK-QAGDV(G) n RGDS] to investigate the relationship of these receptor recognition domains of fibrinogen to platelet membrane glycoprotein IIb/IIIa. The tetrapeptide RGDS, the GRGDSPA peptide and the dodecapeptide inhibited binding of fibrinogen to GPIIb/IIIa by 50% (IC50) at concentrations of 17 ± 1.6 μM, 15 ± 2.1 μM, and 87 ± 6.8 μM, respectively. The inhibitory effect of hybrid peptides increased as the number of glycine

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Strandberg, Erik, Deniz Tiltak, Marco Ieronimo, Nathalie Kanithasen, Parvesh Wadhwani та Anne S. Ulrich. "Influence of C-terminal amidation on the antimicrobial and hemolytic activities of cationic α-helical peptides". Pure and Applied Chemistry 79, № 4 (2007): 717–28. http://dx.doi.org/10.1351/pac200779040717.

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The effect of C-terminal amidation on the antimicrobial and hemolytic activities of antimicrobial peptides was studied using three cationic peptides which form amphiphilic α-helices when bound to membranes. The natural antimicrobial peptide PGLa, the designer-made antibiotic MSI-103, and the cell-penetrating "model amphipathic peptide" (MAP) are all amidated in their original forms, and their biological activities were compared with the same sequences carrying a free C-terminus. It was found that, in general, a free COOH-terminus reduces both the antimicrobial activity and the hemolytic side e

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Obasse, Idira, Mark Taylor, Nigel J. Fullwood, and David Allsop. "Development of proteolytically stable N-methylated peptide inhibitors of aggregation of the amylin peptide implicated in type 2 diabetes." Interface Focus 7, no. 6 (2017): 20160127. http://dx.doi.org/10.1098/rsfs.2016.0127.

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Islet amyloid polypeptide, also known as amylin, is the main component of the amyloid deposits present in approximately 90% of people with type 2 diabetes mellitus (T2DM). In this disease, amylin aggregates into multimeric β-pleated sheet structures which cause damage to pancreatic islet β-cells. Inhibitors of early-stage amylin aggregation could therefore provide a disease-modifying treatment for T2DM. In this study, overlapping peptides were designed to target the ‘binding’ region (RLANFLVHSS, residues 11–20) of human amylin, and their effects on amyloid fibril formation were determined by t

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Nossner, E., J. E. Goldberg, C. Naftzger, S. C. Lyu, C. Clayberger, and A. M. Krensky. "HLA-derived peptides which inhibit T cell function bind to members of the heat-shock protein 70 family." Journal of Experimental Medicine 183, no. 2 (1996): 339–48. http://dx.doi.org/10.1084/jem.183.2.339.

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Synthetic peptides corresponding to sequences of HLA class I molecules have inhibitory effects on T cell function. The peptides investigated in this study have sequences corresponding to the relatively conserved region of the alpha 1 helix of HLA class I molecules that overlaps the "public epitope" Bw4/Bw6. These HLA-derived peptides exhibit inhibitory effects on T lymphocytes and have beneficial effects on the survival of allogenic organ transplants in mice and rats. Peptides corresponding to the Bw4a epitope appear most potent as they inhibit the differentiation of T cell precursors into mat

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Kannan, Arvind, Navam Hettiarachchy, and Satya Narayan. "Colon and Breast Anti-cancer Effects of Peptide Hydrolysates Derived from Rice Bran." Open Bioactive Compounds Journal 2, no. 1 (2009): 17–20. http://dx.doi.org/10.2174/1874847300902010017.

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Rice bran is an economical, under-utilized co-product of rough rice milling. The objective of this study was to produce rice-bran peptides and investigate for anti-cancer activity. Protein hydrolysates were prepared by treating heat stabilized defatted rice-bran with food grade Alcalase enzyme, followed by treatment with simulated gastric and intestinal juices to obtain resistant peptides. Resistant peptides were fractionated into >50, 10-50, 5-10, and <5 kDa sizes, freeze dried, and evaluated for inhibitory and cytotoxicity activities on human colon (HCT-116) and breast (HTB-26) cancer

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Wong, Philip Ching Yat, Jun Guo, and Aidong Zhang. "The renal and cardiovascular effects of natriuretic peptides." Advances in Physiology Education 41, no. 2 (2017): 179–85. http://dx.doi.org/10.1152/advan.00177.2016.

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The landmark report by de Bold et al. in 1981 signified the heart as one of the endocrine organs involved in fluid and salt balance (de Bold AJ, Borenstein HB, Veress AT, Sonnenberg H. Life Sci 28: 89–94, 1981). Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are secreted from cardiomyocytes in response to cardiac stretch as in the case of heart failure, whereas C-type natriuretic peptide (CNP) is secreted from endothelial and renal cells in response to cytokines and endothelium-dependent agonists, such as acetylcholine. Binding ANP or BNP to natriuretic peptide receptor A

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Kojima, Suzuka, Hitomi Nakamura, Sungho Lee, Fukue Nagata, and Katsuya Kato. "Hydroxyapatite Formation on Self-Assembling Peptides with Differing Secondary Structures and Their Selective Adsorption for Proteins." International Journal of Molecular Sciences 20, no. 18 (2019): 4650. http://dx.doi.org/10.3390/ijms20184650.

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Self-assembling peptides have been employed as biotemplates for biomineralization, as the morphologies and sizes of the inorganic materials can be easily controlled. We synthesized two types of highly ordered self-assembling peptides with different secondary structures and investigated the effects of secondary structures on hydroxyapatite (HAp) biomineralization of peptide templates. All as-synthesized HAp-peptides have a selective protein adsorption capacity for basic protein (e.g., cytochrome c and lysozyme). Moreover, the selectivity was improved as peptide amounts increased. In particular,

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Rigel, D. F. "Effects of neuropeptides on heart rate in dogs: comparison of VIP, PHI, NPY, CGRP, and NT." American Journal of Physiology-Heart and Circulatory Physiology 255, no. 2 (1988): H311—H317. http://dx.doi.org/10.1152/ajpheart.1988.255.2.h311.

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This study was designed to evaluate the potential chronotropic actions of several cardiac neuropeptides in pentobarbital-anesthetized dogs. After bilateral vagotomy and stellectomy and muscarinic receptor blockade, I injected vasoactive intestinal polypeptide, peptide histidine isoleucine, neuropeptide Y, neurotensin, and calcitonin gene-related peptide into the intact sinus node artery. Neurotensin, calcitonin gene-related peptide, and neuropeptide Y exhibited no physiologically significant changes in heart rate. However, the structural homologues vasoactive intestinal polypeptide and peptide

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Henning, R. "Vasoactive intestinal peptide: cardiovascular effects." Cardiovascular Research 49, no. 1 (2001): 27–37. http://dx.doi.org/10.1016/s0008-6363(00)00229-7.

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Patgiri, Anupam, Stephen T. Joy, and Paramjit S. Arora. "Nucleation Effects in Peptide Foldamers." Journal of the American Chemical Society 134, no. 28 (2012): 11495–502. http://dx.doi.org/10.1021/ja301953j.

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Smolarczyk, Ryszard, Tomasz Cichoń, Wojciech Kamysz, et al. "Anticancer effects of CAMEL peptide." Laboratory Investigation 90, no. 6 (2010): 940–52. http://dx.doi.org/10.1038/labinvest.2010.58.

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Wei, Wei, Shue Wang, Xue-Jun Zhang, et al. "The Effects of Mung Bean Peptide and Its’ Complexes on the Treatment of Lead Poisoning." Journal of Food Quality 2021 (July 22, 2021): 1–7. http://dx.doi.org/10.1155/2021/2851146.

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Objective. To investigate the effects of mung bean peptide and its’ complexes on promoting lead excretion and neuroprotection of zebrafish. Methods. The lead poisoning models of zebrafish were established by lead acetate solution; the models were treated with high and low concentrations (58.3 and 175 μg/mL) of mung bean peptides, with high, medium, and low concentrations (27.8, 83.3, and 250 μg/mL) of mung bean peptide complexes, separately. The effects of the mung bean peptide complexes on the lead content, axonal fluorescence intensity, and peripheral motor nerve length changes were identifi

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Kellner, Michael, Ines Diehl, Kristina Knaudt, Cornelius Schüle, Holger Jahn, and Klaus Wiedemann. "C-type natriuretic peptide exerts stimulatory effects on the corticotropin-releasing hormone-induced secretion of hormones in normal man." European Journal of Endocrinology 136, no. 4 (1997): 388–93. http://dx.doi.org/10.1530/eje.0.1360388.

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Abstract C-type natriuretic peptide and atrial natriuretic peptide have been reported to bind to distinct receptors and to exert opposing effects on different systems. Although it is known that atrial natriuretic peptide inhibits the corticotropin-releasing hormone-stimulated hormone release in man, the corresponding action of C-type natriuretic peptide has so far not been characterized. We investigated the effects of 30-min infusions of 150 and 300 μg C-type natriuretic peptide on adrenocorticotropin, cortisol, and prolactin release stimulated by 100 μg corticotropin-releasing hormone and on

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Kasetty, Gopinath, Praveen Papareddy, Martina Kalle, et al. "Structure-Activity Studies and Therapeutic Potential of Host Defense Peptides of Human Thrombin." Antimicrobial Agents and Chemotherapy 55, no. 6 (2011): 2880–90. http://dx.doi.org/10.1128/aac.01515-10.

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ABSTRACTPeptides of the C-terminal region of human thrombin are released upon proteolysis and identified in human wounds. In this study, we wanted to investigate minimal determinants, as well as structural features, governing the antimicrobial and immunomodulating activity of this peptide region. Sequential amino acid deletions of the peptide GKYGFYTHVFRLKKWIQKVIDQFGE (GKY25), as well as substitutions at strategic and structurally relevant positions, were followed by analyses of antimicrobial activity against the Gram-negative bacteriaEscherichia coliandPseudomonas aeruginosa, the Gram-positiv

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Björstad, Åse, Huamei Fu, Anna Karlsson, Claes Dahlgren, and Johan Bylund. "Interleukin-8-Derived Peptide Has Antibacterial Activity." Antimicrobial Agents and Chemotherapy 49, no. 9 (2005): 3889–95. http://dx.doi.org/10.1128/aac.49.9.3889-3895.2005.

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ABSTRACT Chemokines are inflammatory mediators with effects on diverse processes associated with the immune response. Some of the proteins belonging to the CXC chemokine subfamily, one of four groups in the family, possess inherent antibacterial activity against a wide range of bacteria. The CXC chemokine interleukin-8 (IL-8) has not been ascribed any direct antibacterial activity, but the fact that several of the amino acids in the carboxy-terminal part of the protein are identical or similar to those in a bactericidal cecropin-like peptide [Hp(2-20)] from Helicobacter pylori suggests that pr

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Abu-Hamdah, Rania, Atoosa Rabiee, Graydon S. Meneilly, Richard P. Shannon, Dana K. Andersen, and Dariush Elahi. "The Extrapancreatic Effects of Glucagon-Like Peptide-1 and Related Peptides." Journal of Clinical Endocrinology & Metabolism 94, no. 6 (2009): 1843–52. http://dx.doi.org/10.1210/jc.2008-1296.

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Fleeman, Renee M., Luis A. Macias, Jennifer S. Brodbelt, and Bryan W. Davies. "Defining principles that influence antimicrobial peptide activity against capsulatedKlebsiella pneumoniae." Proceedings of the National Academy of Sciences 117, no. 44 (2020): 27620–26. http://dx.doi.org/10.1073/pnas.2007036117.

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The extracellular polysaccharide capsule ofKlebsiella pneumoniaeresists penetration by antimicrobials and protects the bacteria from the innate immune system. Host antimicrobial peptides are inactivated by the capsule as it impedes their penetration to the bacterial membrane. While the capsule sequesters most peptides, a few antimicrobial peptides have been identified that retain activity against encapsulatedK. pneumoniae,suggesting that this bacterial defense can be overcome. However, it is unclear what factors allow peptides to avoid capsule inhibition. To address this, we created a peptide

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Khavinson, Vladimir, Anastasiia Ilina, Nina Kraskovskaya, et al. "Neuroprotective Effects of Tripeptides—Epigenetic Regulators in Mouse Model of Alzheimer’s Disease." Pharmaceuticals 14, no. 6 (2021): 515. http://dx.doi.org/10.3390/ph14060515.

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KED and EDR peptides prevent dendritic spines loss in amyloid synaptotoxicity in in vitro model of Alzheimer’s disease (AD). The objective of this paper was to study epigenetic mechanisms of EDR and KED peptides’ neuroprotective effects on neuroplasticity and dendritic spine morphology in an AD mouse model. Daily intraperitoneal administration of the KED peptide in 5xFAD mice from 2 to 4 months of age at a concentration of 400 μg/kg tended to increase neuroplasticity. KED and EDR peptides prevented dendritic spine loss in 5xFAD-M mice. Their action’s possible molecular mechanisms were investig

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Porcher, Christophe, Aurélie Juhem, André Peinnequin, Valérie Sinniger, and Bruno Bonaz. "Expression and effects of metabotropic CRF1 and CRF2 receptors in rat small intestine." American Journal of Physiology-Gastrointestinal and Liver Physiology 288, no. 5 (2005): G1091—G1103. http://dx.doi.org/10.1152/ajpgi.00302.2004.

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Corticotropin-releasing factor (CRF)-like peptides mediate their effects via two receptor subtypes, CRF1 and CRF2; these receptors have functional implication in the motility of the stomach and colon in rats. We evaluated expression and functions of CRF1 and CRF2 receptors in the rat small intestine (i.e., duodenum and ileum). CRF1–2-like immunoreactivity (CRF1–2-LI) was localized in fibers and neurons of the myenteric and submucosal ganglia. CRF1–2-LI was found in nerve fibers of the longitudinal and circular muscle layers, in the mucosa, and in mucosal cells. Quantitative RT-PCR showed a str

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Rodrigues, Elaine G., Andrey S. Dobroff, Carlos P. Taborda, and Luiz R. Travassos. "Antifungal and antitumor models of bioactive protective peptides." Anais da Academia Brasileira de Ciências 81, no. 3 (2009): 503–20. http://dx.doi.org/10.1590/s0001-37652009000300015.

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Peptides are remarkably reactive molecules produced by a great variety of species and able to display a number of functions in uni-and multicellular organisms as mediators, agonists and regulating substances. Some of them exert cytotoxic effects on cells other than those that produced them, and may have a role in controlling subpopulations and protecting certain species or cell types. Presently, we focus on antifungal and antitumor peptides and discuss a few models in which specific sequences and structures exerted direct inhibitory effects or stimulated a protective immune response. The kille

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Michalek, Matthias, Bruno Vincent, Rainer Podschun, Joachim Grötzinger, Burkhard Bechinger, and Sascha Jung. "Hydramacin-1 in Action: Scrutinizing the Barnacle Model." Antimicrobial Agents and Chemotherapy 57, no. 7 (2013): 2955–66. http://dx.doi.org/10.1128/aac.02498-12.

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ABSTRACTHydramacin-1 (HM1) from the metazoanHydraexerts antimicrobial activity against a wide range of bacterial strains. Notably, HM1 induces the aggregation of bacterial cells, accompanied by precipitation. To date, the proposed mechanism of peptide-lipid interaction, termed the barnacle model, has not been described on the molecular level. Here, we show by biochemical and biophysical techniques that the lipid-peptide interactions of HM1 are initiated by electrostatic and hydrophobic effects, in particular, by tryptophan and neighboring polar amino acid residues that cause an interfacial loc

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Al-Khafaji, Ali Jabbar Oleiwi. "The Effects of Extracted Peptide from Skin of Iraqi Frog (Rana ridibunda) on Human Leukemic Lymphocytes." Baghdad Science Journal 16, no. 1 (2019): 0040. http://dx.doi.org/10.21123/bsj.16.1.0040.

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The purified frog skin peptides were tested on leukemic patients lymphocytes, which revealed effects of cytotoxicity. Four frogs (Rana ridibunda) were stimulated by single intra-peritoneal injection of norepinephrine-HCl . Five different peptides;1(18) A, 2(19) L, 3(20) I,4(21) E and 5(22) Y were isolated and quantified. The peptide 3(20)I had 5.87% of hemolysis, while healthy human lymphocytes cytotoxic activity was for 2(19)L with inhibition( -10.4%).All peptides were subjected to polyacrylamide gel electrophoresis. The results revealed peptides 1(18)A, 2(19)L, 3(20)I which appeared as low a

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