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Dissertations / Theses on the topic 'Peptide in solution NMR study'

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Published: 4 June 2021

Last updated: 5 February 2022

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1

Smith, K. I. "The two-dimensional nuclear magnetic resonance spectroscopy analysis of peptides in solution." Thesis, University of Manchester, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377720.

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2

Nowak, Cheryl L. "Design, synthesis, and evaluation of bicyclic peptides as ammonium ionophores." Link to electronic thesis, 2003. http://www.wpi.edu/Pubs/ETD/Available/etd-0428103-180827/.

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Thesis (M.S.)--Worcester Polytechnic Institute.<br>Keywords: solution 13C-NMR study; olid phase peptide synthesis; bicyclic peptides; ammonium ionophores; valinomycin; ion selective electrode. Includes bibliographical references (p. 63-65).

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3

Driscoll, P. C. "'1H NMR studies of plastocyanin in solution." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382519.

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4

Bieganski, Robert Marius. "NMR study of peptide derivatives in cryoprotective media and dimethyl sulfoxide." Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/43294.

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5

Rhodes, Laura Anne. "An NMR study of the solution conformations of some metal complexes." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394735.

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6

Zhong, Muning. "An NMR study of the conformation and solution behavior of sinefungin." Scholarly Commons, 1995. https://scholarlycommons.pacific.edu/uop_etds/2293.

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Sinefungin is an antibiotic and a close structural analog of S-adenosylmethionine, a co-factor for a vast number of enzymes. Sinefungin is one of a class of natural products containing both nucleoside and amino acid moieties. Sinefungin is a conformationally complex molecule. Because the sinefungin molecule consists of a planar adenine ring capable of both syn and anti orientation with respect to a conformationally mobile ribose ring and a flexible amino acid side chain, it has a wide range of conformational features that may be related to its bioactivity. Both lD and 2D F1NMR methods were use

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7

Qian, Jin. "The dynamics of peptide-16 in DMPC bilayer membranes, an NMR relaxation study." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ27464.pdf.

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8

Amero, Carlos D. "Protein Function Study by NMR Spectroscopy." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1205431343.

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9

Zou, Yan. "Study of Lone Pair-Arene Interactions in Solution." Miami University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=miami1186024674.

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10

Agostinho, de Oliveira Joao Carlos. "Study of peptide interactions in solution through the use of local correlation methods." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://hdl.handle.net/11858/00-1735-0000-0023-994D-1.

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11

Pei, Hongxia. "Bead Modeling of Transport Properties of Macromolecules in Free Solution and in a Gel." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/chemistry_diss/49.

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On the bead modeling methodology, or BMM, a macromolecule is modeled as a rigid, non-overlapping bead array with arbitrary radii. The BMM approach was pioneered by Kirkwood and coworkers (Kirkwood, J.G., Macromolecules, E.P. Auer (Ed.), Gordon and Breach, New York, 1967; Kirkwood, J.G., Riseman, J., J. Chem. Phys., 1948, 16, 565) and applied to such transport properties as diffusion, sedimentation, and viscosity. With the availability of computers, a number of investigators extended the work to account for the detailed shape of biomolecules in the 1970s. A principle objective of my research

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12

Macqueen, Robin Michael. "A ²H-NMR study of lipid chain disorder in a model membrane : effect of integral peptide length." Thesis, University of British Columbia, 1986. http://hdl.handle.net/2429/26003.

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Polypeptides of the form: Lys₂-Gly-Leu[sub n]-Lys₂-Ala-amide with n=16, 20 or 24, and of the form: Ac-Leu₁₀-Lys₂-Ala-amide, were mixed with perdeuterated potassium palmitate at peptide/lipid ratios of approximately 1:200 and 1:100. Potassium phosphate buffer (50mM) was added such that the water:lipid molar ratio was 7.75:1. ²H-NMR measurements were made on the samples at 49°C and 65°C. The effect of all peptides was to cause an increase in lipid chain order which varied linearly with concentration. This increase was manifested by an increase in average order parameter for the entire lipid

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13

Bell, Mary-Jane C. (Mary-Jane Constance) Carleton University Dissertation Chemistry. "A multinuclear NMR study on the interactions between metal ions and nucleic acid derivatives in solution." Ottawa, 1985.

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14

Goto, Natalie Kazumi. "The development and application of methods for the study of multi-domain protein structure by solution NMR." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ58917.pdf.

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15

Wu, Yanqiu. "Development of methods to evaluate the utility of detergents for membrane protein study by solution NMR spectroscopy." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27307.

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Structure determination of membrane proteins by solution nuclear magnetic resonance spectroscopy requires that they can be incorporated into detergent micelles in order to ensure that they are maintained in a folded, water-soluble state. However, some detergents appear to disrupt structurally important interactions between transmembrane (TM) helices, while others produce micelle-protein complexes that may be too large for solution NMR. As a result there are a limited number of detergents suitable for solution NMR studies, making the search for better solution conditions one of the remaining ch

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16

Pudelko, Maciej. "Antigens derived from the mucin MUC1 : Solution and solid-phase synthesis of saccharides, peptides and glycopeptides." Doctoral thesis, Umeå : Department of Chemistry, Umeå Univ, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1630.

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17

Sarkar, Riddhiman. "Long lived states in high field NMR spectroscopy for the study of very slow dynamic processes in solution state /." [S.l.] : [s.n.], 2009. http://library.epfl.ch/theses/?nr=4508.

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18

Probert, Fay. "A solution state NMR study of the structure and ligand binding properties of the human C-type lectin DC-SIGNR." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/56380/.

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The protein DC-SIGNR (Dendritic-cell specific ICAM3 grabbing non-integrin related) is a C-type (calcium-dependent) lectin, which binds highly-branched mannose oligosaccharides. DC-SIGNR interacts with a range of deadly diseases via surface glycans on pathogenic glycoproteins, and the ability of DC-SIGNR to increase the rate of infection of viruses including human immunodeficiency virus (HIV) and hepatitis C virus (HCV) makes the study of DC-SIGNR/oligosaccharide interactions very attractive. The research described in this thesis sought to gain insight into the calcium and ligand binding proper

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19

Lindström, Fredrick. "Biological membrane interfaces involved in diseases : a biophysical study." Doctoral thesis, Umeå universitet, Kemi, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-806.

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Interactions between peptides and biological lipid membranes play a crucial role in many cellular processes such as in the mechanism behind Alzheimer’s disease where amyloid-beta peptide (Abeta)is thought to be a key component. The initial step of binding between a surface active peptide and its target membrane or membrane receptor can involve a non specific electrostatic association where positively charged amino acid residues and a negatively charged membrane surface interact. Here, the use of high resolution MAS NMR provides a highly sensitive and non perturbing way of studying the electros

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20

Murphy, K. J. "An NMR and molecular modelling study on the solution conformation of Heparan Sulphate : new insights into the relationship between structure and function." Thesis, University of Huddersfield, 2007. http://eprints.hud.ac.uk/id/eprint/189/.

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A deeper insight into the structural biology of HS is key to understanding its nearuniversal functional role as a co-receptor for growth factors and morphogens. Due to the extreme difficulty in preparing homogeneous HS oligosaccharides for structural and functional studies, traditionally, oligosaccharides derived from the related molecule heparin are used as HS structural models. In this study a number of authentic HS derived hexasaccharides, in addition to heparin derived hexasaccharides, have been purified in sufficient quantity to permit a detailed NMR and molecular modelling based analysis

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21

Agostinho, de Oliveira Joao Carlos [Verfasser], Ricardo [Akademischer Betreuer] Mata, and PETER [Akademischer Betreuer] BOTSCHWINA. "Study of peptide interactions in solution through the use of local correlation methods / Joao Carlos Agostinho de Oliveira. Gutachter: Ricardo Mata ; Peter Botschwina. Betreuer: Ricardo Mata." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://d-nb.info/1063154464/34.

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22

Jacso, Tomas. "A structural and functional study of the second periplasmic loop P2 of MalF in the maltose transporter of Escherichia coli." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16229.

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ABC (ATP-binding-cassette)-Transporter katalysieren den ATP-abhängigen Transport diverser niedermolekularer Substanzen durch die biologische Zellmembran. Ihr Vorkommen erstreckt sich auf alle drei Domänen des Lebens. Der Maltose Transporter von E.coli gehört zu dieser Superfamilie der ABC-Transporter. Die Kristallstrukturen des Transporters MalFGK2 wurden kürzlich gelöst für dessen inaktiven Zustand als auch für dessen katalytischen Zwischenzustand. Um den Transportmechanismus besser verstehen zu können, müssen die Kristallstrukturen des Transporters und seiner Komponenten unter physiolo

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23

Moakes, Greg. "Study of Lithium Solvation Environments in Water-saturated Nitrobenzene." Diss., Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/14105.

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It was found that there exist three major water environments when water is dissolved in nitrobenzene. 2H NMR has proved that these solvatomers exist irrespective of whether lithium salt is added to the system. 7Li NMR experiments suggested that the first solvatomer is majority nitrobenzene, the second a mixed solvation shell consisting of nitrobenzene and water and the third solvatomer is a large water aggregated at the glass surface. The mixed solvation state is short lived and is promoted by addition of water of by supersaturating the system upon cooling. This is a high energy state and deca

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24

Mangavel, Cécile. "Peptides amphiphiles hélicogènes : comportement en solution aqueuse et interaction avec des membranes modèles." Orléans, 1996. http://www.theses.fr/1996ORLE2043.

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Les interactions entre peptides amphiphiles helicogenes et membranes jouent un role fondamental dans de nombreux mecanismes biologiques. D'une grande diversite de sequences primaires, ces peptides possedent la propriete commune d'adopter une structure secondaire d'helice alpha en presence de membranes. Il semble donc que ce soit cette structure secondaire qui gouverne reellement l'interaction membranaire. Au cours de ce travail, nous nous sommes interesses a des peptides modeles dont les sequences primaires alternent residus hydrophiles et hydrophobes afin de favoriser la formation d'helices a

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25

Xu, Yaochun. "Fluorinated Peptidomimetics : Synthesis, Conformational Studies and Evaluation as Amyloid Proteins Aggregation Modulators." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS585/document.

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La maladie d'Alzheimer représente un défi mondial pour la société. Il n'y a pas à ce jour de traitement efficace pour traiter ou ralentir les symptômes de la maladie d'Alzheimer. Cette maladie est caractérisée par une perte de synapses, une augmentation du nombre de plaques extracellulaires d'Abêta et une augmentation de Tau hyperphosphorylée agrégée intracellulaire (neurodégénérescence fibrillaire). Il est communément admis que la maladie d'Alzheimer est principalement liée à l’oligomérisation et à la fibrillation de peptides amyloïdes bêta, et que les oligomères Abêta solubles et les fibres

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26

Gouvion, Catherine. "Etude de la conformation des oligogalacturonides par résonance magnétique nucléaire et modélisation nucléaire." Grenoble 1, 1993. http://www.theses.fr/1993GRE10025.

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Une etude conformationnelle de quelques oligogalacturonides, de dp2 a 4, obtenus par hydrolyse enzymatique et chromatographie, a ete entreprise par resonance magnetique nucleaire et modelisation moleculaire. Les parametres rmn mesures en solution (constantes de couplage carbone-proton et effets overhauser nucleaires) peuvent etre convertis en parametres geometriques caracteristiques d'une conformation virtuelle moyenne. Par ailleurs des calculs s'appuyant sur le programme de chimie quantique pcilo ont ete effectues pour une serie de composes analogues. Les resultats de ces deux approches (expe

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27

Lachgar, Abdessadek. "Etude cristallographique et spectroscopique de quelques phases nouvelles du systeme k : :(2)o-sb::(2)o::(5)-p::(2)o::(5)." Nantes, 1987. http://www.theses.fr/1987NANT2015.

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Identification de cinq phases nouvelles. Determination de la structure pour chacune d'entre elles par diffraction rx sur monocristal. Les edifices covalents sont construits a partir d'octaedres sbo::(6) partageant des sommets ou des aretes, et de tetraedre po::(4) lies aux octaedres par deux, trois ou leurs quatre sommets. Caracterisation par absorption ir, diffusion raman et spectrometre rmn du **(31)p

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28

Foucat, Loïc. "Etude par rmn de la dynamique rotationnelle du malononitrile." Paris 6, 1987. http://www.theses.fr/1987PA066377.

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Etude de cette molecule de type rotateur asymetrique en solution dans ch::(2)cl::(2), tetrahydrofurane et diglyne. A l'aide de la theorie de la "relaxation couplee" determination des valeurs des trois constantes de diffusion du solute et des densites spectrales relatives aux mecanismes de relaxation dipole-dipole, intra-et intermoleculaire. Etude de l'influence du taux de deuteriation du solvant sur la relaxation du solute dans le cas de ch::(2)cl::(2). Ecart des densites spectrales par rapport aux previsions theoriques. Test de la validite de plusieurs modeles hydrodynamiques: celui de knauss

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29

VIGOUROUX, CECILE. "Microdynamique des solutions : influence des espèces paramagnétiques sur la relaxation en RMN." Université Joseph Fourier (Grenoble), 1998. http://www.theses.fr/1998GRE10068.

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Ce travail concerne l'etude de differents systemes modeles en solution, representant les interactions inter- ou intramoleculaires. L'agent de perturbation est une espece paramagnetique. Nous utilisons le tempol (radical nitroxyde neutre), l'anion nitrosodisulfonate (radical nitroxyde charge) ou des cations lanthanide trivalents. La methode consiste a mesurer des taux de relaxation spin-reseau et des coefficients de diffusion translationnelle par resonance magnetique nucleaire, puis a elaborer un modele theorique ou les valeurs calculees sont les plus proches possibles des valeurs experimentale

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30

Zahidi, Assou. "Etudes structurales et dynamiques de complexes macrocycliques par rmn heteronucleaire." Université Louis Pasteur (Strasbourg) (1971-2008), 1986. http://www.theses.fr/1986STR13171.

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Etude de la complexation de cations et d'anions par des ligands synthetiques a l'aide de la rmn heteronucleaire (**(6)li, **(7)li, **(13)c, **(14)n, **(15)n, **(19)f, **(31)p, **(35)cl et **(109)ag) et de mesures d'effet overhauser homo- et heteronuclaires

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31

Moreira, Ana Sofia Pereira. "Study of modifications induced by thermal and oxidative treatment in oligo and polysaccharides of coffee by mass spectrometry." Doctoral thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/17074.

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Doutoramento em Bioquímica<br>Os polissacarídeos são os componentes maioritários dos grãos de café verde e torrado e da bebida de café. Os mais abundantes são as galactomananas, seguindo-se as arabinogalactanas. Durante o processo de torra, as galactomananas e arabinogalactanas sofrem modificações estruturais, as quais estão longe de estar completamente elucidadas devido à sua diversidade e à complexidade estrutural dos compostos formados. Durante o processo de torra, as galactomananas e arabinogalactanas reagem com proteínas, ácidos clorogénicos e sacarose, originando compostos castanh

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32

Kumar, G. Senthil. "Solution NMR Studies Of Peptide Toxins From Cone Snails And Scorpion." Thesis, 2008. http://hdl.handle.net/2005/862.

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Major constituents of the venom of various animals are peptidogenic in nature. Marine snails belonging to the species Conus are venomous predators that use small, structurally constrained peptides present in their venom for prey capture and defense. It is known that ~500 Conus species are present in nature and the venom of each of these Conus species is a complex mixture of nearly 100 peptides accounting for > 50,000 peptides with little overlap among the different species. The peptides isolated from the venom of Conus species are commonly known as conotoxins or conopeptides. Some of the commo

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33

Chou, Ning. "NMR studies of the solution conformation and dynamics of the tyrocidine peptide antibiotics." 1985. http://catalog.hathitrust.org/api/volumes/oclc/12267239.html.

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34

Lo, Chi-Jen, and 駱啟仁. "Unfolding Study of b Amyloid Peptide by NMR Spectroscopy." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/16150406575180065334.

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碩士<br>國立陽明大學<br>生物化學研究所<br>92<br>Alzheimer’s disease (AD) is a neurodegenerative disease which leads to progressive dementia and neuronal death. Currently, the pathogenesis of this disease is still not yet clear. The main histopathological hallmarks of AD are the senile plaques within the cerebral cortex and the neurofibrillary tangles within the nerve cells. The primary component of senile plaques is □-amyloid peptide (A□□, which is derived from proteolysis of a much larger membrane-spanning protein known as □-amyloid precursor protein (APP). A□ has two major isoforms, A□40 and A□42, containi

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35

Chen, Cheng-Yu. "Studies on Redesign and Solution Structure Determination of Nonribosomal Peptide Synthetases and Redox Regulation of Phosphatases." Diss., 2013. http://hdl.handle.net/10161/7166.

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<p>We present a computational structure-based redesign of the phenylalanine adenylation domain of the non-ribosomal peptide synthetase (NRPS) enzyme gramicidin S synthetase A (GrsA-PheA) for a set of non-cognate substrates for which the wild-type enzyme has little or virtually no specificity. Experimental validation of a set of top-ranked computationally-predicted enzyme mutants shows significant improvement in the specificity for the target substrates. We further present enhancements to the methodology for computational enzyme redesign that are experimentally shown to result in significant ad

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36

Wang, Chih-Ching, and 王誌慶. "Structural study of genetically mutated ��-amyloid peptide by NMR spectroscopy." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/04033426693949592687.

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碩士<br>國立陽明大學<br>生物化學研究所<br>93<br>Alzheimer’s disease (AD) is a neurodegenerative disease which leads to progressive dementia and neuronal death. Currently, the pathogenesis of this disease is still not yet clear. The main histopathological hallmarks of AD are the senile plaques within the cerebral cortex and the neurofibrillary tangles within the nerve cells. The primary component of senile plaques is ��-amyloid peptide (A��w, which is derived from proteolysis of a much larger membrane-spanning protein known as ��-amyloid precursor protein (APP). A�� is a soluble peptide which can be detected

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37

Pin, Pan Chia, and 潘家檳. "Solution structure determination of somatostatin analog and synthetic a-helical peptide using 2D NMR and molecular modelling." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/45961391219905423270.

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38

Chang, Rong-Fong, and 張榮逢. "Study of the effect of bicelle on beta-amyloid peptide structure by NMR spectroscopy." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/51688079657476748572.

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碩士<br>國立陽明大學<br>生命科學系暨基因體科學研究所<br>101<br>Alzheimer’s disease (AD) is a neurodegenerative disease that leads to progressive dementia and neuronal death. The main histopathological hallmarks of AD are senile plaques within the cerebral cortex and neurofibrillary tangles within the neuron cells. The primary component of senile plaque is beta-amyloid peptide (A-beta). A-beta consists of 39-42 residues. It is derived from proteolysis of a membrane-spanning protein known as beta-amyloid precursor protein (APP). AD is thought to be associated with aggregation of A-beta. Several studies suggested that

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39

Li, Xiang. "Study of pure-silica Zeolite Nucleation and Growth from Solution." Thesis, 2011. http://hdl.handle.net/1969.1/ETD-TAMU-2011-08-9825.

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Zeolites are microporous crystalline materials, which are widely used in catalysis, adsorption, and ion-exchange processes. However, in most cases, the synthesis of novel zeolites as functional materials still relies on trial-and-error methods, which are time consuming and expensive. Therefore, the motivation for this thesis work is to understand the zeolite synthesis mechanismand further develop knowledge for manipulating zeolite properties and ultimately the rational design of porous materials. This work focused on formation of silicalite-1 (pure-silica ZSM-5) from basic aqueous solutions co

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40

Peng, Yi-Wei, and 彭佾威. "The conformation study of fragment peptide in Protein Tyrosine Kinase by NMR, CD & Homology Modeling." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/574t47.

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碩士<br>朝陽科技大學<br>應用化學系碩士班<br>93<br>Tyrosine phosphorylation is one of the key covalent modifications that occurs in multicellular organisms as a result of intercellular communication during embryogenesis and maintenance of adult tissues. The enzymes that carry out this modification are the protein tyrosine kinases (PTKs), which catalyze the transfer of the γ phosphate of ATP to tyrosine residues on protein substrate. Phosphorylation of tyrosine residues modulates enzymatic activity and creates binding sites for the recruitment of downstream signaling proteins. Since PTKs are critical components

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41

Tseng, Ya-Lin, and 曾雅琳. "How C-terminal residue alters the helix folding of an amphipathic antimicrobial peptide: CD and NMR study." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/4wmyjv.

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碩士<br>淡江大學<br>化學學系碩士班<br>102<br>One of the most interesting questions in biophysics is how protein sequences determine their unique three-dimensional structure. Previous studies reported that the residues at C-terminal can have effects on the protein folding behaviors. Since a large protein is highly complex, for simplicity, in this study we use MP-B (14 amino acids) and its analogues in 30% TFE-d3 aqueous solution as a model system. By using circular dichroism (CD) and NMR methods, we can get insight into how the C-terminal segment may influence the folding behavior of proteins. Spectra of CD

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42

Cascão, João Bruno Canelas. "Application of NMR RDC’s, relaxation and self-diffusion for the study of dynamic processes of small molecules in solution." Master's thesis, 2014. http://hdl.handle.net/10362/13878.

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Spin-lattice Relaxation, self-Diffusion coefficients and Residual Dipolar Couplings (RDC’s) are the basis of well established Nuclear Magnetic Resonance techniques for the physicochemical study of small molecules (typically organic compounds and natural products with MW < 1000 Da), as they proved to be a powerful and complementary source of information about structural dynamic processes in solution. The work developed in this thesis consists in the application of the earlier-mentioned NMR techniques to explore, analyze and systematize patterns of the molecular dynamic behavior of selected smal

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43

Chang, Han-Chen, та 張翰珍. "Expression and purification 13C- and 15N-labeled β-amyloid peptide and β-amyloid precursor protein 672-731(APP 672-731) for NMR structural analysis and study". Thesis, 2006. http://ndltd.ncl.edu.tw/handle/24635368587136075858.

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碩士<br>國立中正大學<br>分子生物研究所<br>94<br>Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the progressive deposition of the aggregated amyloid β-peptide (Aβ) on the cell surfaces and in the walls of cerebral blood vessels. Aβ is a 39-43 amino acid polypeptide derived from proteolytic cleavages of the β-amyloid precursor protein (APP) by β- and γ-secretase. There are three groups of mutation sites in APP found in AD patients. These mutation sites locate near the ?, β- and γ-secretase cutting sites. It is believed that mutations near the β- and γ-secretase cutting sites induce a

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