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Journal articles on the topic 'Peptide polymere'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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1

Sawada, Toshiki, Hiroki Fukuta, and Takeshi Serizawa. "Preparation of Biocomposite Soft Nanoparticles Composed of Poly(Propylene Oxide) and the Polymer-Binding Peptides." Processes 8, no. 7 (2020): 859. http://dx.doi.org/10.3390/pr8070859.

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The molecular recognition capability of naturally occurring biomolecules is generally expressed against biomolecules in the biological milieu. Recently, it was demonstrated that the specific interactions of biomolecules such as short peptides were applicable to artificial materials. We have developed peptides with specific affinities for synthetic polymers toward functional biocomposite polymeric materials. In this study, we demonstrated the preparation of biocomposite nanoparticles composed of poly(propylene oxide) (PPO) and PPO-binding peptides. A simple injection of a concentrated PPO solut

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Drury, Jeanie L., Tanyarut Boontheekul, and David J. Mooney. "Cellular Cross-linking of Peptide Modified Hydrogels." Journal of Biomechanical Engineering 127, no. 2 (2004): 220–28. http://dx.doi.org/10.1115/1.1865194.

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Peptide modification of hydrogel-forming materials is being widely explored as a means to regulate the phenotype of cells immobilized within the gels. Alternatively, we hypothesized that the adhesive interactions between cells and peptides coupled to the gel-forming materials would also enhance the overall mechanical properties of the gels. To test this hypothesis, alginate polymers were modified with RGDSP-containing peptides and the resultant polymer was used to encapsulate C2C12 myoblasts. The mechanical properties of these gels were then assessed as a function of both peptide and cell dens

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Silva-Flannery, Luciana M., Monica Cabrera-Mora, Megan Dickherber, and Alberto Moreno. "Polymeric Linear Peptide Chimeric Vaccine-Induced Antimalaria Immunity Is Associated with Enhanced In Vitro Antigen Loading." Infection and Immunity 77, no. 5 (2009): 1798–806. http://dx.doi.org/10.1128/iai.00470-08.

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ABSTRACT Immunization of mice with Plasmodium berghei or Plasmodium yoelii synthetic linear peptide chimeras (LPCs) based on the circumsporozoite protein protects against experimental challenge with viable sporozoites. The immunogenicity of LPCs is significantly enhanced by spontaneous polymerization. To better understand the antigenic properties of polymeric antimalarial peptides, we studied the immune responses elicited in mice immunized with a polymer or a monomer of a linear peptide construct specific for P. yoelii and compared the responses of antigen-presenting cells following incubation

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Munjulury, Venkata Sai Dheeraj, and Robertina Calico. "Assessment of Modern Excipients in Controlled Delivery of Proteins and Peptides." Journal of Drug Delivery and Therapeutics 10, no. 6-s (2020): 134–38. http://dx.doi.org/10.22270/jddt.v10i6-s.4631.

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Polymeric micelles are highly proficient of modulating the function, distribution of drugs in the body, and can overcome biological barriers hence provoked as novel nanomedicine via various formulations. Current review emphasis on application of several polymers, biomaterials, lipids for the preparation of polymeric micelles formed by several molecular interactions between the block co-polymers and encapsulated molecules. Micellar carriers will be selected on basis of the type of polymer/payload interaction, which includes biological interface focused on the internal chemistry and fabrication

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Koschek, Katharina, Vedat Durmaz, Oxana Krylova, et al. "Peptide–polymer ligands for a tandem WW-domain, an adaptive multivalent protein–protein interaction: lessons on the thermodynamic fitness of flexible ligands." Beilstein Journal of Organic Chemistry 11 (May 18, 2015): 837–47. http://dx.doi.org/10.3762/bjoc.11.93.

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Three polymers, poly(N-(2-hydroxypropyl)methacrylamide) (pHPMA), hyperbranched polyglycerol (hPG), and dextran were investigated as carriers for multivalent ligands targeting the adaptive tandem WW-domain of formin-binding protein (FBP21). Polymer carriers were conjugated with 3–9 copies of the proline-rich decapeptide GPPPRGPPPR-NH2 (P1). Binding of the obtained peptide–polymer conjugates to the tandem WW-domain was investigated employing isothermal titration calorimetry (ITC) to determine the binding affinity, the enthalpic and entropic contributions to free binding energy, and the stoichiom

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Kolel-Veetil, Manoj K., LCDR Luis Estrella, Christopher R. So, and Kenan P. Fears. "Extremely tough cyclic peptide nanopolymers." MRS Advances 4, no. 46-47 (2019): 2527–32. http://dx.doi.org/10.1557/adv.2019.363.

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ABSTRACTWe present a new class of bioinspired nanomaterials that are stabilized by a combination of covalent and hydrogen bonds. Prior work by others has shown that cyclic peptides can self-assemble to form supramolecular assemblies through backbone-backbone hydrogen bonding. To improve upon this molecular architecture, we develop a synthesis route to polymerize cyclic peptides and form a linear polymer chain that can transition between a rigid nanorod and an unfolded conformation. For a cyclic peptide polymer containing amine-terminated side chains on each ring, we demonstrate self-assembly c

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Keen, Imelda, Lynette Lambert, Traian V. Chirila, Stefan M. Paterson, and Andrew K. Whittaker. "Degradable Hydrogels for Tissue Engineering – Part I: Synthesis by RAFT Polymerization and Characterization of PHEMA Containing Enzymatically Degradable Crosslinks." Journal of Biomimetics, Biomaterials and Tissue Engineering 6 (September 2010): 67–85. http://dx.doi.org/10.4028/www.scientific.net/jbbte.6.67.

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A nonapeptide, which is sensitive to enzymatic digestion by collagenase, was modified by the covalent attachment of an acrylamido group at the terminal positions. The functionalized peptide was used as a crosslinking agent during polymerization of 2-hydroxyethyl methacrylate (HEMA). Reversible addition-fragmentation chain transfer (RAFT) method was used to obtain a polymer (PHEMA) with an average theoretical molecular weight of 4000 Da, containing enzymatically labile peptide crosslinks. The functionalized peptide was analyzed in detail by 1H and 13C nuclear magnetic resonance (NMR) spectromet

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8

Iijima, Kazutoshi, Hiroumi Nagahama, Akari Takada, Toshiki Sawada, Takeshi Serizawa, and Mineo Hashizume. "Surface functionalization of polymer substrates with hydroxyapatite using polymer-binding peptides." Journal of Materials Chemistry B 4, no. 21 (2016): 3651–59. http://dx.doi.org/10.1039/c6tb00624h.

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Polymer substrates were modified with hydroxyapatite (HAp) using two bi-functional peptides consists of polymer-binding peptide and triasparate for HAp mineralization in simulated body fluids and HAp-binding peptide for immobilization HAp nanoparticles.

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9

Zhang, Xiaorong, Giorgio Caserta, Aysu Yarman, et al. "“Out of Pocket” Protein Binding—A Dilemma of Epitope Imprinted Polymers Revealed for Human Hemoglobin." Chemosensors 9, no. 6 (2021): 128. http://dx.doi.org/10.3390/chemosensors9060128.

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The epitope imprinting approach applies exposed peptides as templates to synthesize Molecularly Imprinted Polymers (MIPs) for the recognition of the parent protein. While generally the template protein binding to such MIPs is considered to occur via the epitope-shaped cavities, unspecific interactions of the analyte with non-imprinted polymer as well as the detection method used may add to the complexity and interpretation of the target rebinding. To get new insights on the effects governing the rebinding of analytes, we electrosynthesized two epitope-imprinted polymers using the N-terminal pe

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Pulido, David, Rocío Rebollido-Rios, Javier Valle, David Andreu, Ester Boix, and Marc Torrent. "Structural similarities in the CPC clip motif explain peptide-binding promiscuity between glycosaminoglycans and lipopolysaccharides." Journal of The Royal Society Interface 14, no. 136 (2017): 20170423. http://dx.doi.org/10.1098/rsif.2017.0423.

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Lipopolysaccharides (LPSs) and glycosaminoglycans (GAGs) are polymeric structures containing negatively charged disaccharide units that bind to specialized proteins and peptides in the human body and control fundamental processes such as inflammation and coagulation. Surprisingly, some proteins can bind both LPSs and GAGs with high affinity, suggesting that a cross-communication between these two pathways can occur. Here, we explore whether GAGs and LPSs can share common binding sites in proteins and what are the structural determinants of this binding. We found that the LPS-binding peptide YI

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Woerly, S., G. Laroche, R. Marchand, J. Pato, V. Subr, and K. Ulbrich. "Intracerebral Implantation of Hydrogel-Coupled Adhesion Peptides: Tissue Reaction." Journal of Neural Transplantation and Plasticity 5, no. 4 (1995): 245–55. http://dx.doi.org/10.1155/np.1994.245.

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Arg-Gly-Asp peptides (RGD) were synthesized and chemically coupled to the bulk of N-(2-hydroxypropyl) methacrylamide-based polymer hydrogels. Fourier Transform Infrared Spectroscopy (FFIR) and amino acid analysis confirmed the peptide coupling to the polymer. Activated and control (unmodified) polymer matrices were stereotaxically implanted in the striata of rat brains, and two months later the brains were processed for immunohistochemistry using antibodies for glial acidic fibrillary protein (GFAP), laminin and neurofilaments. RGD-containing polymer matrices promoted stronger adhesion to the

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Kim, Pyung-Hwan, and Sung Wan Kim. "Polymer-Based Delivery of Glucagon-Like Peptide-1 for the Treatment of Diabetes." ISRN ENDOCRINOLOGY 2012 (May 30, 2012): 1–14. http://dx.doi.org/10.5402/2012/340632.

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The incretin hormones, glucagon-like peptide-1 (GLP-1) and its receptor agonist (exendin-4), are well known for glucose homeostasis, insulinotropic effect, and effects on weight loss and food intake. However, due to the rapid degradation of GLP-1 by dipeptidylpeptidase-IV (DPP-IV) enzyme and renal elimination of exendin-4, their clinical applications have been restricted. Although exendin-4 has longer half-life than GLP-1, it still requires frequent injections to maintain efficacy for the treatment of diabetes. In recent decades, various polymeric delivery systems have been developed for the d

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Locock, Katherine E. S. "Bioinspired Polymers: Antimicrobial Polymethacrylates." Australian Journal of Chemistry 69, no. 7 (2016): 717. http://dx.doi.org/10.1071/ch16047.

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Naturally occurring antimicrobial peptides have been honed by evolution over millions of years to give highly safe and efficacious antimicrobials that form part of many organisms’ immune systems. By studying these peptides to identify key aspects of structure and composition, suitable synthetic polymer mimics can be designed that hold potential as anti-infective agents. This review focusses on an important aspect of peptide mimicry, that of replicating the chemical functionality provided by key amino acids present in antimicrobial peptides. These include polymethacrylate mimics of arginine-ric

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Cantor, Stefania, Lina Vargas, Oscar Rojas A., Cristhian Yarce, Constain Salamanca, and Jose Oñate-Garzón. "Evaluation of the Antimicrobial Activity of Cationic Peptides Loaded in Surface-Modified Nanoliposomes against Foodborne Bacteria." International Journal of Molecular Sciences 20, no. 3 (2019): 680. http://dx.doi.org/10.3390/ijms20030680.

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Bacteria are a common group of foodborne pathogens presenting public health issues with a large economic burden for the food industry. Our work focused on a solution to this problem by evaluating antibiotic activity against two bacteria (Listeria monocytogenes and Escherichia coli) of relevance in the field of foodstuffs. We used two approaches: (i) structural modification of the antimicrobial peptides and (ii) nano-vehiculisation of the modified peptides into polymer-coated liposomes. To achieve this, two antimicrobial peptides, herein named ‘peptide +2′ and ‘peptide +5′ were synthesised usin

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15

Chapman, Robert, Katrina A. Jolliffe, and Sébastien Perrier. "Synthesis of Self-assembling Cyclic Peptide-polymer Conjugates using Click Chemistry." Australian Journal of Chemistry 63, no. 8 (2010): 1169. http://dx.doi.org/10.1071/ch10128.

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Self-assembling cyclic peptide-polymer conjugates were prepared by ‘clicking’ polymers (prepared by RAFT polymerization) to an azide functionalized d-alt-l cyclic octapeptide via the Huisgen 1,3-dipolar cycloaddition reaction. Due to the high graft density, the efficiency of the click chemistry conjugation reaction was found to be highly dependent on the size of the polymer. At relatively low molecular weights, as many as four polymer chains could be grafted to each 8 residue cyclic peptide ring. Evidence for the self assembly of the conjugates into peptide-polymer nanotubes was observed by TE

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Zhao, Lili, Wanli Jin, Jazmina Gonzalez Cruz, et al. "Development of Polyelectrolyte Complexes for the Delivery of Peptide-Based Subunit Vaccines against Group A Streptococcus." Nanomaterials 10, no. 5 (2020): 823. http://dx.doi.org/10.3390/nano10050823.

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Peptide subunit vaccines hold great potential compared to traditional vaccines. However, peptides alone are poorly immunogenic. Therefore, it is of great importance that a vaccine delivery platform and/or adjuvant that enhances the immunogenicity of peptide antigens is developed. Here, we report the development of two different systems for the delivery of lipopeptide subunit vaccine (LCP-1) against group A streptococcus: polymer-coated liposomes and polyelectrolyte complexes (PECs). First, LCP-1-loaded and alginate/trimethyl chitosan (TMC)-coated liposomes (Lip-1) and LCP-1/alginate/TMC PECs (

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17

Böhmová, Eliška, Robert Pola, Michal Pechar, et al. "Polymer Cancerostatics Containing Cell-Penetrating Peptides: Internalization Efficacy Depends on Peptide Type and Spacer Length." Pharmaceutics 12, no. 1 (2020): 59. http://dx.doi.org/10.3390/pharmaceutics12010059.

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Cell-penetrating peptides (CPPs) are commonly used substances enhancing the cellular uptake of various cargoes that do not easily cross the cellular membrane. CPPs can be either covalently bound directly to the cargo or they can be attached to a transporting system such as a polymer carrier together with the cargo. In this work, several CPP–polymer conjugates based on copolymers of N-(2-hydroxypropyl)methacrylamide (pHPMA) with HIV-1 Tat peptide (TAT), a minimal sequence of penetratin (PEN), IRS-tag (RYIRS), and PTD4 peptide, and the two short hydrophobic peptides VPMLK and PFVYLI were prepare

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18

Boivin, Marie Claude, P. Chevallier, Stéphane Turgeon, Jean Lagueux, and Gaetan Laroche. "Micropatterning Polymer Materials to Improve Endothelialization." Advanced Materials Research 409 (November 2011): 777–82. http://dx.doi.org/10.4028/www.scientific.net/amr.409.777.

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Several studies have shown that 65 % of expanded poly (tetrafluoroethylene) (ePTFE) vascular prostheses had to be explanted within 10 years of implantation in humans. The reasons for these explantations relied on thrombosis formation and poor hemocompatibility of synthetic polymers. It has been shown that surface modification of ePTFE arterial prostheses could enable their endothelialization therefore improving their biocompatibility and hemocompatibility. Indeed, endothelial cells naturally cover the biological blood vessel wall and consequently, an endothelial layer constitutes the best achi

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Chersi, Alberto, Francesca di Modugno, and Giuliana Falasca. "Specifities of Rabbit Antisera to Multiple Antigen (MAP) Peptides." Zeitschrift für Naturforschung C 50, no. 9-10 (1995): 735–38. http://dx.doi.org/10.1515/znc-1995-9-1023.

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Abstract Two multiple antigen peptides consisting of 6 and 7 amino acid residues, respectively, plus a 12-residue fragment, used as a control, all linked to a polylysine core, were used as immunogens in rabbits in order to obtain an immune response. Rabbit antisera against such polymers were then tested in ELISA against a panel of antigens in order to analyze the specificites of the resulting antibodies. The responses were different for all three immunogens, being partially or totally directed, for two of the three compounds, including the 12-residue control MAP peptide, against the polylysyl

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Camacho, Paula, Hafiz Busari, Kelly B. Seims, Peter Schwarzenberg, Hannah L. Dailey, and Lesley W. Chow. "3D printing with peptide–polymer conjugates for single-step fabrication of spatially functionalized scaffolds." Biomaterials Science 7, no. 10 (2019): 4237–47. http://dx.doi.org/10.1039/c9bm00887j.

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21

Guo, Ruo-Chen, Xue-Hao Zhang, Lei Ji, et al. "Recent progress of therapeutic peptide based nanomaterials: from synthesis and self-assembly to cancer treatment." Biomaterials Science 8, no. 22 (2020): 6175–89. http://dx.doi.org/10.1039/d0bm01358g.

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22

Sun, Fusheng, Xiaoxue Xie, Yufan Zhang, et al. "Effects of Cold Jet Atmospheric Pressure Plasma on the Structural Characteristics and Immunoreactivity of Celiac-Toxic Peptides and Wheat Storage Proteins." International Journal of Molecular Sciences 21, no. 3 (2020): 1012. http://dx.doi.org/10.3390/ijms21031012.

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The present research reported the effects of structural properties and immunoreactivity of celiac-toxic peptides and wheat storage proteins modified by cold jet atmospheric pressure (CJAP) plasma. It could generate numerous high-energy excited atoms, photons, electrons, and reactive oxygen and nitrogen species, including O3, H2O2, •OH, NO2− and NO3− etc., to modify two model peptides and wheat storage proteins. The Orbitrap HR-LC-MS/MS was utilized to identify and quantify CJAP plasma-modified model peptide products. Backbone cleavage of QQPFP and PQPQLPY at specific proline and glutamine resi

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Algayer, Bethany, Ann O’Brien, Aaron Momose, et al. "Novel pH Selective, Highly Lytic Peptides Based on a Chimeric Influenza Hemagglutinin Peptide/Cell Penetrating Peptide Motif." Molecules 24, no. 11 (2019): 2079. http://dx.doi.org/10.3390/molecules24112079.

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Delivery of macromolecular cargos such as siRNA to the cytosol after endocytosis remains a critical challenge. Numerous approaches including viruses, lipid nanoparticles, polymeric constructs, and various peptide-based approaches have yet to yield a general solution to this delivery issue. In this manuscript, we describe our efforts to design novel endosomolytic peptides that could be used to facilitate the release of cargos from a late endosomal compartment. These amphiphilic peptides, based on a chimeric influenza hemagglutinin peptide/cell-penetrating peptide (CPP) template, utilize a pH-tr

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Camacho, Paula, Matthew Fainor, Kelly B. Seims, John W. Tolbert, and Lesley W. Chow. "Fabricating spatially functionalized 3D-printed scaffolds for osteochondral tissue engineering." Journal of Biological Methods 8, no. 1 (2021): e146. http://dx.doi.org/10.14440/jbm.2021.353.

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Three-dimensional (3D) printing of biodegradable polymers has rapidly become a popular approach to create scaffolds for tissue engineering. This technique enables fabrication of complex architectures and layer-by-layer spatial control of multiple components with high resolution. The resulting scaffolds can also present distinct chemical groups or bioactive cues on the surface to guide cell behavior. However, surface functionalization often includes one or more post-fabrication processing steps, which typically produce biomaterials with homogeneously distributed chemistries that fail to mimic t

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Nishimura, Shin-nosuke, Nobuyuki Higashi, and Tomoyuki Koga. "Synthesis of peptide–vinyl polymer multiblock hybrids by nitroxide-mediated polymerization: breaking the limitations of monomer compatibility." Polymer Chemistry 10, no. 1 (2019): 71–76. http://dx.doi.org/10.1039/c8py01330f.

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Nitroxide-mediated polymerization of a wide variety of vinyl monomers using a novel TIPNO-based cyclic peptide successfully provided multiblock architectures composed of sequential peptides and vinyl polymers in one step.

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Yuca, Esra, Sheng-Xue Xie, Linyong Song, et al. "Reconfigurable Dual Peptide Tethered Polymer System Offers a Synergistic Solution for Next Generation Dental Adhesives." International Journal of Molecular Sciences 22, no. 12 (2021): 6552. http://dx.doi.org/10.3390/ijms22126552.

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Resin-based composite materials have been widely used in restorative dental materials due to their aesthetic, mechanical, and physical properties. However, they still encounter clinical shortcomings mainly due to recurrent decay that develops at the composite-tooth interface. The low-viscosity adhesive that bonds the composite to the tooth is intended to seal this interface, but the adhesive seal is inherently defective and readily damaged by acids, enzymes, and oral fluids. Bacteria infiltrate the resulting gaps at the composite-tooth interface and bacterial by-products demineralize the tooth

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Cesari, Andrea, Alessandra Recchimurzo, Angela Fabiano, et al. "Improvement of Peptide Affinity and Stability by Complexing to Cyclodextrin-Grafted Ammonium Chitosan." Polymers 12, no. 2 (2020): 474. http://dx.doi.org/10.3390/polym12020474.

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Cyclodextrin-grafted polymers are attractive biomaterials that could bring together the host–guest complexing capability of pristine cyclodextrin and the pharmaceutical features of the polymeric backbone. The present paper is aimed at characterizing the potential application of ammonium–chitosan grafted with 2-methyl-β-cyclodextrin (N+-rCh-MCD) as the functional macromolecular complexing agent for the oral administration of the neuropeptide dalargin (DAL). Specific NMR characterization procedures, along with UV and fluorescence techniques, as well as biological in vitro assessments have been p

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Ahmed, Marya. "Peptides, polypeptides and peptide–polymer hybrids as nucleic acid carriers." Biomaterials Science 5, no. 11 (2017): 2188–211. http://dx.doi.org/10.1039/c7bm00584a.

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Oriana, Sean, Ye Cai, Jeffrey W. Bode, and Yoko Yamakoshi. "Synthesis of tri-functionalized MMP2 FRET probes using a chemo-selective and late-stage modification of unprotected peptides." Organic & Biomolecular Chemistry 15, no. 8 (2017): 1792–800. http://dx.doi.org/10.1039/c7ob00150a.

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A polymeric FRET probe for the detection of MMP2 was prepared using a new N-hydroxylamine derivative of lysine, which was successfully incorporated into the natural peptide sequence by solid phase peptide synthesis, allowing dual orthogonal ligations of the fully unprotected peptides.

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Kamaruzzaman, Nor Fadhilah, Li Peng Tan, Ruhil Hayati Hamdan, et al. "Antimicrobial Polymers: The Potential Replacement of Existing Antibiotics?" International Journal of Molecular Sciences 20, no. 11 (2019): 2747. http://dx.doi.org/10.3390/ijms20112747.

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Antimicrobial resistance is now considered a major global challenge; compromising medical advancements and our ability to treat infectious disease. Increased antimicrobial resistance has resulted in increased morbidity and mortality due to infectious diseases worldwide. The lack of discovery of novel compounds from natural products or new classes of antimicrobials, encouraged us to recycle discontinued antimicrobials that were previously removed from routine use due to their toxicity, e.g., colistin. Since the discovery of new classes of compounds is extremely expensive and has very little suc

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Paik, Bradford A., Marco A. Blanco, Xinqiao Jia, Christopher J. Roberts, and Kristi L. Kiick. "Aggregation of poly(acrylic acid)-containing elastin-mimetic copolymers." Soft Matter 11, no. 9 (2015): 1839–50. http://dx.doi.org/10.1039/c4sm02525c.

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Polymer–peptide conjugates were produced via the copper-catalyzed azide–alkyne cycloaddition of poly(tert-butyl acrylate) (PtBA) and elastin-like peptides. The aggregation of the conjugates was evaluated experimentally and computationally.

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Tan, Stephanie, Gaelen Moore, and Justin Nodwell. "Put a Bow on It: Knotted Antibiotics Take Center Stage." Antibiotics 8, no. 3 (2019): 117. http://dx.doi.org/10.3390/antibiotics8030117.

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Ribosomally-synthesized and post-translationally modified peptides (RiPPs) are a large class of natural products produced across all domains of life. The lasso peptides, a subclass of RiPPs with a lasso-like structure, are structurally and functionally unique compared to other known peptide antibiotics in that the linear peptide is literally “tied in a knot” during its post-translational maturation. This underexplored class of peptides brings chemical diversity and unique modes of action to the antibiotic space. To date, eight different lasso peptides have been shown to target three known mole

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Chistov, A. A., A. V. Talanova, M. V. Melnikova, S. S. Kuznetsova, and E. F. Kolesanova. "An Improved Procedure for the Preparation of Thrombin Low Molecular Weight Substrates - Peptide p-Nitroanilides." Biomedical Chemistry: Research and Methods 1, no. 4 (2018): e00057. http://dx.doi.org/10.18097/bmcrm00057.

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Low molecular weight chromogenic thrombin peptide substrates, p-nitroanilides of short peptides protected at their N-terminal amino group, were prepared by solid-phase peptide synthesis on polystyrene-divinylbenzene polymer with trityl groups with preliminary attached p-phenylene diamine moiety. After the cleavage from the resin peptide p-aminoanilides were mildly oxidized to p-nitroanilides with the mixture of potassium sulfate and persulfate. Adsorption onto polymer support Bio-Beads SM-2 with further elution by acetonitrile allowed easy separating peptide p-nitroanilides from the oxidizer a

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Chen, Jing, Fangyingkai Wang, Qiuming Liu, and Jianzhong Du. "Antibacterial polymeric nanostructures for biomedical applications." Chem. Commun. 50, no. 93 (2014): 14482–93. http://dx.doi.org/10.1039/c4cc03001j.

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A topical review on recent advances in the research and applications of antimicrobial polymeric nanostructures, such as silver-decorated polymeric nanostructures, and polymeric micelles and vesicles based on antimicrobial polymers and antimicrobial peptides.

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Climacosa, Fresthel Monica M., Ruby Anne N. King, Bobbie Marie M. Santos, and Salvador Eugenio C. Caoili. "Development and Characterization of Polymeric Peptides for Antibody Tagging of Bacterial Targets." Protein & Peptide Letters 27, no. 10 (2020): 962–70. http://dx.doi.org/10.2174/0929866527666200427212940.

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Background: Microbe-Binding Peptides (MBPs) are currently being investigated to address the problem of antimicrobial resistance. Strategies enhancing their antimicrobial activity have been developed, including peptide dimerization. Here, we present an alternative approach based on peptide polymerization, yielding hapten-labelled polymeric MBPs that mediate tagging of bacteria with anti-hapten antibodies, for enhanced immune recognition by host phagocytes. Methods: C-terminally amidated analogs of the bacterial-binding peptide IIGGR were synthesized, with or without addition of cysteine residue

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Siau, Jia Wei, Samuel Nonis, Sharon Chee, et al. "Directed co-evolution of interacting protein–peptide pairs by compartmentalized two-hybrid replication (C2HR)." Nucleic Acids Research 48, no. 22 (2020): e128-e128. http://dx.doi.org/10.1093/nar/gkaa933.

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Abstract Directed evolution methodologies benefit from read-outs quantitatively linking genotype to phenotype. We therefore devised a method that couples protein–peptide interactions to the dynamic read-out provided by an engineered DNA polymerase. Fusion of a processivity clamp protein to a thermostable nucleic acid polymerase enables polymerase activity and DNA amplification in otherwise prohibitive high-salt buffers. Here, we recapitulate this phenotype by indirectly coupling the Sso7d processivity clamp to Taq DNA polymerase via respective fusion to a high affinity and thermostable interac

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Martins, Joana N., João Carlos Lima, and Nuno Basílio. "Selective Recognition of Amino Acids and Peptides by Small Supramolecular Receptors." Molecules 26, no. 1 (2020): 106. http://dx.doi.org/10.3390/molecules26010106.

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To this day, the recognition and high affinity binding of biomolecules in water by synthetic receptors remains challenging, while the necessity for systems for their sensing, transport and modulation persists. This problematic is prevalent for the recognition of peptides, which not only have key roles in many biochemical pathways, as well as having pharmacological and biotechnological applications, but also frequently serve as models for the study of proteins. Taking inspiration in nature and on the interactions that occur between several receptors and peptide sequences, many researchers have

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Cárdenas, Constanza, Fanny Guzmán, Marisela Carmona, et al. "Synthetic Peptides as a Promising Alternative to Control Viral Infections in Atlantic Salmon." Pathogens 9, no. 8 (2020): 600. http://dx.doi.org/10.3390/pathogens9080600.

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Viral infections in salmonids represent an ongoing challenge for the aquaculture industry. Two RNA viruses, the infectious pancreatic necrosis virus (IPNV) and the infectious salmon anemia virus (ISAV), have become a latent risk without healing therapies available for either. In this context, antiviral peptides emerge as effective and relatively safe therapeutic molecules. Based on in silico analysis of VP2 protein from IPNV and the RNA-dependent RNA polymerase from ISAV, a set of peptides was designed and were chemically synthesized to block selected key events in their corresponding infectiv

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Buchanan, Claire, Christopher J. Garvey, Patrick Perlmutter та Adam Mechler. "Co-assembly of helical β3-peptides: a self-assembled analogue of a statistical copolymer". Pure and Applied Chemistry 89, № 12 (2017): 1809–16. http://dx.doi.org/10.1515/pac-2017-0709.

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AbstractUnnatural peptide self-assembly offers the means to design hierarchical nanostructures of controlled geometries, chemical function and physical properties. N-acyl β3 peptides, where all residues are unnatural amino acids, are able to form helical fibrous structures by a head-to-tail assembly of helical monomers, extending the helix via a three point supramolecular hydrogen bonding motif. These helical nanorods were shown to be stable under a wide range of physical conditions, offering a self-assembled analogue of polymeric fibres. Hitherto the self-assembly has only been demonstrated b

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Gudivada, Vijaya Narasimha, Chen-Ji Huang, Yueh-Hsia Luo, and Guo-Chung Dong. "A Cyclic BMP-2 Peptide Upregulates BMP-2 Protein-Induced Cell Signaling in Myogenic Cells." Polymers 13, no. 15 (2021): 2549. http://dx.doi.org/10.3390/polym13152549.

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In the current study, we designed four cyclic peptide analogues by incorporating two cysteine residues in a BMP-2 linear knuckle epitope in such a way that the active region of the peptide could be either inside or outside the cyclic ring. Bone morphogenetic protein receptor BMPRII was immobilized on the chip surface, and the interaction of the linear and cyclic peptide analogues was studied using surface plasmon resonance (SPR). From the affinity data, the peptides with an active region inside the cyclic ring had a higher binding affinity in comparison to the other peptides. To confirm that o

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Kakwere, Hamilton, Candy K. Y. Chun, Katrina A. Jolliffe, Richard J. Payne, and Sébastien Perrier. "Polymer–peptide chimeras for the multivalent display of immunogenic peptides." Chemical Communications 46, no. 13 (2010): 2188. http://dx.doi.org/10.1039/b924112d.

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Ubukata, Yuu. "Kinetics of polymeric substrate (dextrin or peptone) removal by activated sludge: hydrolysis of polymers to monomers is the rate-determining step." Water Science and Technology 36, no. 12 (1997): 159–67. http://dx.doi.org/10.2166/wst.1997.0443.

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Most of the organic compounds in primary effluent are polymers such as proteins and polysaccharides. However the bacteria present in activated sludge (AS) can only directly take up monomers such as amino acids and glucose which are produced from polymers by hydrolysis. Therefore, it is assumed that the hydrolysis of polymers to monomers by the bacteria is the rate-determining step in polymer removal. In this study, AS was acclimated to dextrin or peptone, and polymers (dextrin or peptone) and monomers (glucose or a mixture of free amino acids) were used as substrates for kinetic tests. The rem

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Cheng, Bei, and Peisheng Xu. "Redox-Sensitive Nanocomplex for Targeted Delivery of Melittin." Toxins 12, no. 9 (2020): 582. http://dx.doi.org/10.3390/toxins12090582.

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Although peptide therapeutics have been explored for decades, the successful delivery of potent peptides in vitro and in vivo remains challenging due to the poor stability, low cell permeability, and off-target effects. We developed a redox sensitive polymer-based nanocomplex which can efficiently and stably deliver the peptide drug melittin for cancer therapy. The nanocomplex selectively targets cancer cells through lactobionic acid mediated endocytosis and releases melittin intracellularly upon the trigger of elevated redox potential. In vivo study proved that the targeted nanocomplex shows

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Yeh, J. H., T. Takagi, and S. Sasaki. "Isolation of Two Bovine Amelogenin Peptides and Their Amino Acid Sequences." Advances in Dental Research 1, no. 2 (1987): 276–81. http://dx.doi.org/10.1177/08959374870010021701.

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Two peptide fractions of bovine amelogenin having a highly aggregative property to form polymers were purified by chromatography, SDS-polyacrylamide gel electrophoresis, and HPLC. Amino acid sequences of purified peptides were determined by automated Edman degradation. One peptide was found to be composed of 63 amino acid residues having a molecular weight of 7105, and the other of 86 residues having that of 9683. The sequence of the smaller peptide was identical to the C-terminal 63 residues of the amelogenin molecule of 170 residues previously reported, but the larger contained eight residue

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Hou, Huiwen, Juan Wang, Jie Wang, et al. "A Review of Bioactive Peptides: Chemical Modification, Structural Characterization and Therapeutic Applications." Journal of Biomedical Nanotechnology 16, no. 12 (2020): 1687–718. http://dx.doi.org/10.1166/jbn.2020.3001.

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In recent years, the development and applications of protein drugs have attracted extensive attention from researchers. However, the shortcomings of protein drugs also limit their further development. Therefore, bioactive peptides isolated or simulated from protein polymers have broad application prospects in food, medicine, biotechnology, and other industries. Such peptides have a molecular weight distribution between 180 and 1000 Da. As a small molecule substance, bioactive peptide is usually degraded by various enzymes in the organism and have a short half-life. At the same time, such subst

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Oz Gleenberg, Iris, Orna Avidan, Yehuda Goldgur, Alon Herschhorn, and Amnon Hizi. "Peptides Derived from the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 as Novel Inhibitors of the Viral Integrase." Journal of Biological Chemistry 280, no. 23 (2005): 21987–96. http://dx.doi.org/10.1074/jbc.m414679200.

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Recent studies have shown that the integrase (IN) of HIV-1 is inhibited in vitro by HIV-1 reverse transcriptase (RT). We further investigated the specific protein sequences of RT that were involved in this inhibition by screening a complete library of RT-derived peptides for their inhibition of IN activities. Two 20-residue peptides, peptide 4286, derived from the RT DNA polymerase domain, and the one designated 4321, from the RT ribonuclease H domain, inhibit the enzymatic activities of IN in vitro. The former peptide inhibits all three IN-associated activities (3′-end processing, strand tran

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Callmann, Cassandra E., Matthew P. Thompson, and Nathan C. Gianneschi. "Poly(peptide): Synthesis, Structure, and Function of Peptide–Polymer Amphiphiles and Protein-like Polymers." Accounts of Chemical Research 53, no. 2 (2020): 400–413. http://dx.doi.org/10.1021/acs.accounts.9b00518.

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Hentschel, Jens, Mattijs G. J. ten Cate, and Hans G. Börner. "Peptide-Guided Organization of Peptide−Polymer Conjugates: Expanding the Approach from Oligo- to Polymers." Macromolecules 40, no. 26 (2007): 9224–32. http://dx.doi.org/10.1021/ma071810z.

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Ergene, Cansu, and Edmund F. Palermo. "Antimicrobial Synthetic Polymers: An Update on Structure-Activity Relationships." Current Pharmaceutical Design 24, no. 8 (2018): 855–65. http://dx.doi.org/10.2174/1381612824666180213140732.

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The rising incidence of antibiotic-resistant infections, combined with a declining number of new antibiotic drug approvals, has generated an alarming therapeutic gap that critically undermines public health. Host Defense Peptides (HDPs), sometimes referred to as “Nature’s Antibiotics”, are short chain, amphiphilic and cationic peptide sequences found in all multicellular organisms as part of their innate immunity. While there is a vast diversity in terms of HDP sequence and secondary structure, they all seem to share physiochemical characteristics that can be appropriated for macromolecular de

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Graham, Kate L., Weiguang Zeng, Yoshikazu Takada, David C. Jackson та Barbara S. Coulson. "Effects on Rotavirus Cell Binding and Infection of Monomeric and Polymeric Peptides Containing α2β1 and αxβ2 Integrin Ligand Sequences". Journal of Virology 78, № 21 (2004): 11786–97. http://dx.doi.org/10.1128/jvi.78.21.11786-11797.2004.

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ABSTRACT Integrin-using rotaviruses bind MA104 cell surface α2β1 integrin via the Asp-Gly-Glu (DGE) sequence in virus spike protein VP4 and interact with αxβ2 integrin during cell entry through outer capsid protein VP7. Infection is inhibited by the α2β1 ligand Asp-Gly-Glu-Ala (DGEA) and the αxβ2 ligand Gly-Pro-Arg-Pro (GPRP), and virus-α2β1 binding is increased by α2β1 activation. In this study, we analyzed the effects of monomers and polymers containing DGEA-, GPRP-, and DGEA-related peptides on rotavirus binding and infection in intestinal (Caco-2) and kidney (MA104) cells and virus binding

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