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Dissertations / Theses on the topic 'Peptide Secretion'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Parr, John Henry. "The secretion of the connecting peptide of proinsulin (C-peptide) in thyroid disease." Thesis, University of Liverpool, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329437.

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2

Taskinen, P. (Panu). "Mapping the cellular mechanisms regulating atrial natriuretic peptide secretion." Doctoral thesis, Oulun yliopisto, 1999. http://urn.fi/urn:isbn:9514252721.

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Abstract Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are cardiac hormones, which are involved in the regulation of blood pressure and fluid homeostasis. The major determinant for ANP and BNP release are atrial and ventricular wall stretch, but also some vasoactive factors such as endothelin-1 (ET-1) can enhance cardiac hormone secretion. The mechanical stretch rapidly activates multiple signal transduction pathways in cardiac cells, but the cellular mechanisms mediating stretch-induced ANP secretion are still unknown. The aim of the present study was to examine the ce

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3

ANINI, YOUNES. "Peptide yy et peptides derives du proglucagon : liberation et effet sur la secretion pancreatique exocrine." Paris 6, 1999. http://www.theses.fr/1999PA066014.

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Le peptide yy (pyy) et les peptides derives du proglucagon (pdpg) sont liberes dans la circulation sanguine par les cellules endocrines de type l de l'ileon distal et du colon, apres l'ingestion d'un repas. Chez le rat, l'etude comparee de la liberation du pyy apres administration intraduodenale, intraileale ou intracolique d'un repas mixte (21 kj) ou de nutriments, a montre que le pyy etait libere plus rapidement et de facon plus importante apres l'administration intraduodenale, par un mecanisme indirect, prenant naissance dans l'intestin proximal, nerveux, nicotinique, impliquant la liberati

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4

Ng, Ming Tak. "Effects of prominsulin C-peptide and other islet peptides on beta-cell function and insulin secretion." Thesis, University of Ulster, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.554231.

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Hyperglycaemia is a significant pathophysiological feature of diabetes mellitus. It has been considered to be a cause as well as a consequence of impaired pancreatic p-cell function and insulin action. The detrimental effects of a hyperglycaemic environment encourage the non-enzymatic glycation of regulatory and functional proteins. This thesis investigated the effects of pro insulin C-peptide and other important islet peptides such as insulin, somatostatin, islet amyloid polypeptide (IAPP) as well as the gut hormone gastric inhibitory polypeptide (GIP) in both native and glycated forms on ins

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5

Del, Linz S. J. L. "Scanning ion conductance microscopy : modelling and approaches to studying peptide secretion." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1331878/.

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Scanning ion conductance microscopy (SICM) offers a number of benefits for both imaging and recording from biological samples. However, several fundamental issues concerning this technique, including the image resolution, remain to be clearly understood. In this thesis a model of SICM has been developed to address these issues. This model is quite general and can accommodate arbitrary geometries for both the probe and the sample surface. Model simulations using simple geometries are in good agreement with known analytical solutions and experimental data. The simulations have therefore been ext

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6

Higgins, Paul B. "Intestinal peptides and ethnic differences in insulin secretion." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2006. http://www.mhsl.uab.edu/dt/2006p/higgins.pdf.

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7

Chahal, Sabreen. "Structural characterization of the MATα prepro-peptide secretion leader in Pichia pastoris". Scholarly Commons, 2016. https://scholarlycommons.pacific.edu/uop_etds/166.

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The methylotrophic yeast, Pichia pastoris, is the most successful and favored microbial eukaryotic expression system for the production of recombinant proteins for biopharmaceutical or industrial purposes. P. pastoris has the ability to produce foreign proteins at high levels extracellularly, and since it secretes few endogenous proteins, this ability eliminates the need for expensive purification costs. It also combines the ease of genetic manipulation with rapid growth to high cell densities and provides complex posttranslational modifications. The most commonly utilized secretion signal lea

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8

Meloche, Robert Mark. "The study of humoral inhibition of gastric acid secretion." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24862.

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Part I Inhibition of Gastric Acid Secretion Fat in the small bowel is a powerful inhibitor of gastric acid secretion. The gastric inhibitory agent(s) liberated from intestinal mucosa by the presence of fat has been named enterogastrone. Gastric inhibitory polypeptide (GIP), has been considered a candidate for enterogastrone. GIP is released into the circulation by infusion of fat into the proximal small bowel and inhibits gastric acid secretion under select experimental conditions. It has been proposed that the release of somatostatin, a potent inhibitor of acid secretion, may mediate the gas

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9

Yu, Julie C.-M. "Endothelin peptide secretion and receptor expression in human cultured vascular smooth muscle cells." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242935.

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10

Newton, Julia L. "Changes in gastrointestinal secretion in relation to advancing age and Helicobacter pylori infection." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244553.

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11

Kao, Jonathan. "Atrial natriuretic peptide in aging rats : evidence for altered processing, secretion and receptor binding." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/28993.

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The recently discovered atrial natriuretic peptide (ANP) has potent diuretic, natriuretic and hypotensive effects, and is believed to be involved in the maintenance of sodium homeostasis in both normal and pathological conditions. The mammalian aging process is associated with a host of abnormalities that include, among others, a compromised ability to regulate sodium homeostasis. There are reports that demonstrate a positive correlation between plasma ANP levels and age in man; accordingly, the aim of this study was to examine whether age-related sodium imbalance is associated with disturbanc

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12

Salehi, Marzieh. "The Role of Glucagon-like Peptide 1 in Insulin Secretion after Gastric Bypass Surgery." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1282921101.

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13

Bruneau, Benoit Gaëtan. "Natriuretic peptide secretion and gene expression in isolated rat atria following mechanical or neuroendocrine stimulation." Thesis, University of Ottawa (Canada), 1996. http://hdl.handle.net/10393/10154.

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The natriuretic, diuretic, and vasorelaxant hormones atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) are synthesized and secreted mainly from the mammalian atria of the heart, and are crucial for the maintenance of cardiovascular homeostasis. Direct stimulation of isolated adult rat atrial tissue by stretch, endothelin-1, and phenylephrine was conducted to attempt to define the mechanisms invoked in controlling the secretion and gene expression of ANF and BNP in adult atrial cardiocytes. These stimuli represent models for mechanical, autocrine/paracine, and neuroendocrine s

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14

SOULI, ABDELAZIZ. "Mecanismes d'action du peptide yy sur la secretion de l'eau dans l'intestin grele du rat." Paris 7, 1997. http://www.theses.fr/1997PA077076.

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Le peptide yy (pyy) est une hormone de 36 acides amines, synthetisee et liberee principalement par les cellules endocrines de type l de l'intestin distal. Ce peptide est structuralement proche du neuropeptide y (npy), tres abondant dans les neurones centraux et peripheriques, et a un moindre degre du polypeptide pancreatique (pp). Ces peptides inhibent la secretion d'eau et d'electrolytes dans l'intestin, mais les donnees de la litterature relatives au mecanisme de cet effet sont confuses. Le but de ce travail etait l'etude du mecanisme d'action du pyy sur la secretion d'eau dans l'intestin gr

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15

Taylor, Carolyn Valerie Livsey. "The endogenous cleavage sites, secretion, and activity of catestatin, a novel catecholamine release-inhibitory peptide /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2001. http://wwwlib.umi.com/cr/ucsd/fullcit?p3025946.

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16

RIBARD, DIDIER. "Effet inhibiteur de l'octapeptide c-terminal de l'oxyntomoduline sur la secretion acide gastrique stimulee par la pentagastrine chez l'homme." Montpellier 1, 1989. http://www.theses.fr/1989MON11040.

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17

Port, Gary C. "Exploring the Listeria monocytogenes secretome : identification and functional characterization of novel virulence factors and secretion systems /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/4981.

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18

Rocca, Antonio Stevereves. "Direct and indirect effects of fatty acids on secretion of the antidiabetic hormone, glucagon-like peptide-1." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0020/NQ53857.pdf.

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19

Källner, Göran. "Release and effects of calcitonin gene-related peptide in myocardial ischaemia /." Oslo ; Stockholm : Scandinavian Univ. Press, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980911kall.

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20

Tharaux, Pierre-Louis. "Etude de la secretion du brain natriuretic peptide et du peptide auriculaire natriuretique dans le modele du retrecissement mitral chez l'homme et revue generale de la litterature." Paris 5, 1998. http://www.theses.fr/1998PA05N129.

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21

Esfandyari, Tuba. "The role of calcitonin gene-related peptide (CGRP) in colonic inflammation and secretion in the rat distal colon." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ48000.pdf.

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22

MOORE, COURTNEY MARIE. "EFFECT OF A HETEROBIVALENT GLUCAGON LIKE PEPTIDE-1 LINKED TO CHOLECYSTOKININ ON INSULIN SECRETION IN PANCREATIC β-CELLS". Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/613295.

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A goal of diabetes therapeutics is to deliver agents that target insulin secreting pancreaticβ-cells with high specificity while leaving other cells unaffected.Linking two ligands for two different receptors promotes binding to cells expressing the complementary receptors, thereby increasing the specificity for the target cells. Both Glucagon LikePeptide 1 (GLP-1) and Cholecystokinin (CCK) receptors are expressed on the surface of pancreatic β-cells. A ligand composed of GLP-1 linked to CCK-6 was produced and evaluated for its effect on β-cell insulin secretion. A combination of unlinked monom

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23

Kim, Daniel. "Characterization of the MATα pre-/pro- peptide by mutagenesis as a means to optimize secretion in pichia pistoris". Scholarly Commons, 2009. https://scholarlycommons.pacific.edu/uop_etds/738.

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The unicellular yeast, Pichia pastoris has currently emerged as one of the most popular host systems for heterologous proteins due to its relatively cheap cost, easy genetic manipulability, ability to perform post-translational modifications on proteins, and respiratory growth capabilities which allow it to be cultured in very high concentrations. Over 700 foreign proteins have been recombinantly expressed using P. pastoris. Although P. pastoris appears to be an ideal host system, its main drawback is its inability to efficiently export some heterologous proteins into the extracellular medium.

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24

GALINDO, ESTELLE. "La chromastatine : peptide cryptique de la chromogranine a, regulateur autocrine de la secretion des catecholamines par les cellules chromaffines." Strasbourg 1, 1992. http://www.theses.fr/1992STR13019.

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La chromogranine a est la proteine majeure des granules de secretion des cellules chromaffines. La stimulation des cellules chromaffines par l'acetylcholine conduit, par un mecanisme d'exocytose, a sa co-liberation massive avec les catecholamines dans la circulation sanguine. De recents travaux suggerent que cette proteine ubiquitaire dans le systeme endocrine et neuroendocrine, est le precurseur de nombreux peptides biologiquement actifs. L'un d'entre-eux est genere par une coupure proteolytique dependante du calcul resultant de l'action d'enzymes de type serine proteases. Un analogue synthet

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25

Eto, Bruno. "Action du peptide yy et de ses analogues sur la secretion electrogenique de chlorure, chez l'animal nourri et a jeun." Paris 7, 1996. http://www.theses.fr/1996PA077200.

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L'objectif de ce travail etait de caracteriser les relations entre la structure et la fonction antisecretoire du peptide yy (pyy) et de determiner les aspects de son action physiologique. L'action du pyy et de ses analogues sur le jejunum de rat ou de lapin isole a ete mesure a l'aide des chambres d'ussing, par l'intensite du courant de court-circuit (icc), dependant de la bumetanide (bum) et representant la secretion electrogenique de chlorure. Les resultats sont les suivants: 1) l'utilisation de la bum reduit le coefficient de variation des valeurs de icc. 2) le pyy a diminue l'icc, avec une

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26

SOUALMIA, HAYET. "Etude in vitro des mecanismes de la secretion du peptide auriculaire natriuretique (anp) induite par l'angiotensine ii chez le rat." Paris 6, 1997. http://www.theses.fr/1997PA066558.

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Dans ce travail, nous avons etudie le role de l'angiotensine ii (ang ii) sur la secretion d'anp a partir de tranches d'oreillettes droites de rat a l'aide d'un systeme de perfuison a pression et debit constants. Nous avons observe un effet direct de l'ang ii sur la liberation d'anp a travers les recepteurs at1 de l'ang ii. La secretion d'anp spontanee et induite par l'ang ii depend pour l'essentiel d'une voie metabolique regulee puisque la cycloheximide inhibe partiellement cette secretion. D'autre part l'effet de l'ang ii sur la secretion d'anp est regulee par le monoxyde d'azote a partir de

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27

Mooney, Mark Hugh. "Glucagon like peptide 1 and gastric inhibitory polypeptide : effects of N terminal glycation on hormone degradation, insulin secretion and antihyperglycaemic activity." Thesis, University of Ulster, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268580.

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28

Arnett, Eusondia A. "Neutrophil products inhibit LLO secretion and activity, and Listeria monocytogenes intracellular growth." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1374064718.

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29

Ma, Kenneth Ka-yout. "Brain natriuretic peptide gene expression and secretion following stimulation with pro-inflammatory cytokines and conditioned medium from allo-activated mixed lymphocyte reactions." Thesis, University of Ottawa (Canada), 2004. http://hdl.handle.net/10393/29137.

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Atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) are cardiac-derived polypeptide hormones secreted by the heart. ANF and BNP play critical roles in maintaining fluid and electrolyte balance in both health and disease. Mechanisms of increasing ANF and BNP gene expression and secretion by mechanical or by vasoactive agonists have been thoroughly examined. However, recent experiments suggest that pro-inflammatory cytokines may also be important regulators of natriuretic peptide secretion. In this study, neonatal rat ventricular cardiocyte cultures were used to examine the effec

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30

AMADIEU-FARMAKIS, MARTINE. "Etude de la secretion et des effets physiologiques du peptide natriuretique auriculaire (pna) chez le veau au cours de la periode perinatale." Clermont-Ferrand 2, 1990. http://www.theses.fr/1990CLF21280.

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Le peptide natriuretique auriculaire (pna) est present dans la circulation systemique du ftus bovin au 8#e mois de gestation, du veau nouveau-ne et de la vache adulte gestante ou non gestante. Les concentrations basales moyennes du peptide auriculaire chez le ftus catheterise chroniquement in utero sont 3 a 4 fois superieures a celles de la mere (39,55,5 et 9,40,6 pmol/l respectivement; p<0,01) en fin de gestation suggerant que les cardiocytes ftaux synthetisent et liberent le pna. La fin de la gestation chez la vache est marquee par des taux plasmatiques eleves du peptide auriculaire (9,40,6

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31

RIAD, FOUAD. "Regulation endocrinienne de la secretion salivaire des mineraux chez les bovins." Clermont-Ferrand 2, 1986. http://www.theses.fr/1986CLF21026.

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32

Marquet, Fabrice. "Action de la sorbine sur les sécrétions induites par le VIP et la toxine cholérique à différents niveaux de l'intestin chez le rat, in vivo." Lyon 1, 1998. http://www.theses.fr/1998LYO1T222.

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33

Ananthakrishnan, Kameswari, та Kameswari Ananthakrishnan. "Improved β-Cell Targeting and Therapeutics Using Multivalent Glucagon-Like Peptide-1 (GLP-1) Linked to the α2AR Antagonist Yohimbine (YHB): Evaluating the Binding, Selectivity and Signaling". Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/623004.

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Diabetes Mellitus (DM) is a metabolic disorder in which the body fails to achieve glucose homeostasis, due to either insulin resistance or reduced insulin secretion or both. This inadequate glucose control leads to hyperglycemia which, if left unchecked, leads to secondary complications like nephropathy, neuropathy, retinal degeneration and other serious conditions. In non-disease state, normal glucose level in the blood is maintained by pancreatic β-cells, which secrete insulin. However, during diabetes development, there is loss of β-cell mass and function; resulting in decreased insulin sec

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34

Strannermyr, Malin. "Increased expression of proteins in CHO cells by identification of signal peptides for improved secretion of translated proteins." Thesis, Linköpings universitet, Teknisk biologi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-150364.

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Main purpose of this study was to increase protein expression in Chinese hamster ovary (CHO) cells by improving protein secretion of translated proteins. The goal was to find signal peptides from the screening of signal peptide libraries for improvement of protein secretion using a CHO-cell express selection system. Biopharmaceutical products, proteins such as monoclonal antibodies (mAbs), are most commonly produced using mammalian expression systems such as the expression in CHO cells. The posttranslational modifications of the proteins being expressed in CHO cells are similar to the expressi

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35

McCrudden, Cian Michael. "The identification of peptide precursors of two bradykinin-like peptides from the protective skin secretion of a North American frog, and assessment of their activity from both a physiological and an anti-cancer perspective." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485004.

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To protect themselves from predation, frogs produce and secrete venom that contains bioactive peptides that oft~n mimic those of their mammalian predators. Bradykinin (BK) (RPPGFSPFR) is a nonapeptide that elicits vasodilation, smooth muscle contraction and inflammation in mammals, and it is. present in the protective Ã‚Â·secretions of even the' most primitive frogs. BK is known to be involved in a range of pathological conditions including cancer by proliferation induction and stimulation of angiogenesis. This thesis documents the determination of the therapeutic potential oftwo previously id

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36

Ferment, Olivier. "Retrocontrole du magnesium sur la secretion de l'hormone parathyroidienne et de la calcitonine chez l'homme sain : etude comparee avec le calcium et aspects chronopharmacologiques." Paris 6, 1987. http://www.theses.fr/1987PA066090.

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37

Marenah, Lamin. "Novel peptide discovery : isolation and characterisation of peptides with antidiabetic properties from the skin secretions of amphibians." Thesis, University of Ulster, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274394.

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38

BELIN, VINCENT. "Etude des mecanismes de synchronisation et de recrutement des cellules ocytocinergiques chez la ratte allaitante." Université Louis Pasteur (Strasbourg) (1971-2008), 1986. http://www.theses.fr/1986STR13097.

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L'oxytocine responsable de l'expulsion du lait hors des alveoles de la glande mammaire (ejection de lait) est liberee de la neurohypophyse de facon pulsatile et periodique, les pericaryons sont situes dans les noyaux paraventriculaires et supraoptiques

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39

Dartois, Evelyne. "Inhibition par les glucocorticoides des secretions d'acth et de prostaglandine e::(2) par des cellules hypophysaires : role des lipocortines." Paris 6, 1987. http://www.theses.fr/1987PA066328.

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40

Senthil, Vijayalakshmi. "Structure, activity and relationship studies of peptide and non-peptide analogs with secretin receptor : in search of agonist and/or antagonist." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/207206.

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Class B GPCRs are emerging target in drug research. Currently these receptors serve as drug targets for several drug discovery companies and more than 50 percent of the drugs in the market targets GPCRs. Secretin receptor is found to be expressed in various tissues. Secretin regulates many bodily functions from energy to water homeostasis through both central and peripheral system. Though it holds a history of 100 years, the major drawback is its structural insights. In evidence of its integrated role in physiology as a potential target, the lookout for a novel agonist and / or antagonist for

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41

Moro, Frédéric. "Étude de la régulation de la secrétion et de l'expression de la guanyline et de l'Intestinal Trefoil Factor." Lyon 1, 2000. http://www.theses.fr/2000LYO1T232.

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42

BARAKAT, AMINA. "Mise en evidence de recepteur au peptide alternatif du gene de la calcitonine (pagc) dans les cellules b pancreatiques. Effet du pagc et de l'amyline sur la secretion d'insuline et sur l'expression du gene de l'amyline dans la cellule b." Paris 6, 1993. http://www.theses.fr/1993PA066506.

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L'objectif de la presente these etait d'etudier si le pagc (ou cgrp) et l'amyline (ou iapp) regulent la secretion d'insuline et l'expression du gene de l'amyline dans la cellule b. Nous avons mis en evidence des sites de liaison specifiques du pagc dans les membranes d'insulinomes de hamster et les cellules rinm5f. Dans les deux modeles, les recepteurs lient preferentiellement le pagc de poulet et faiblement l'amyline. Dans les membranes d'insulinome de hamster, deux proteines (38 et 18 kda), couplees a une proteine g, liant specifiquement le pagc ont ete identifiees. Le pagc et l'amyline ont

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43

Wu, Yuxin. "Bioactive peptides from Rana (Odorrana) frog secretions." Thesis, Queen's University Belfast, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603569.

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The studies described in this thesis have focused on the bioactive peptides secreted from the skin glands of Rana (Odorrana) frogs, using different techniques to identify the sequences of novel peptides and to subsequently clone their precursors by molecular genetic techniques and finally, to chemically-synthesize these peptides and examine their bioactivities. Chapters I and 2, respectively, give a general introduction to the field of research and describe the scientific techniques employed in the work. The first experimental chapter, Chapter 3, describes two novel non-canonical bradykinin an

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44

Larsson, Olof. "Peptides as cotransmitters in salivary secretion histochemical, biochemical and functional studies of parotid and submandibular glands /." Stockholm : Kongl. Carolinska Medico Chirurgiska Institutet, 1989. http://catalog.hathitrust.org/api/volumes/oclc/19412146.html.

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45

Terry, Adrian Simon. "Studies on the biosynthesis of neuropeptides." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254521.

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46

Shi, Daning. "Functional studies on the peptides from amphibian skin secretions." Thesis, Queen's University Belfast, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711901.

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Therapeutic peptides are continuing to grow in prominence among pharmaceutical manufacturers. Drugs based on peptides offer lower toxicity, show higher specificity, and demonstrate fewer toxicology issues than small molecule drugs. The specificity of peptides has tremendous clinical value and makes them very attractive and potentially lucrative therapeutics. In order to protect themselves from a great variety of potential predators, amphibians have evolved different morphological, physiological and behavioural features. One such defence mechanism is the secretion from granular skin glands. Fro

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47

Wang, Zhili. "Role of regulatory peptides in the control of islet hormone secretion." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294844.

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48

Pan, Hao. "Studies on novel bioactive peptides from the skin secretion of amphibians." Thesis, Queen's University Belfast, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709692.

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Over many decades, naturally-occurring substances have been considered as an integral part of the treatment of human diseases. Skin secretions from amphibians play an important role for sourcing such agents with therapeutic potential. Amongst all types of substances discovered from amphibian skin secretion, peptides represent a large family of bioactive molecules with distinctive biological functions. To date, more than 2000 host defence peptides have been studied and many of them possess antimicrobial, antifungal or anticancer properties. In the present study, bioactive peptides have been iso

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49

Bensmail, Laila. "Contribution à l'étude de la régulation et de la sécrétion chez Myxococcus xanthus : utilisation comme sonde d'un gène codant une endoglucanase." Rouen, 1996. http://www.theses.fr/1996ROUES065.

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Myxococcus xanthus est une bactérie du sol non pathogène à gram-négatif, qui vit au détriment d'autres microorganismes en sécrétant dans le milieu extérieur des enzymes hydrolytiques pour dégrader sa proie. Elle a un cycle de développement multicellulaire unique chez les procaryotes. Ces caractéristiques font de M. Xanthus un modèle d'étude des mécanismes de sécrétion des protéines. L'étude de la localisation des protéines (exocellulaires chez la bactérie hôte) exprimées chez Escherichia coli a permis d'obtenir dans de nombreux cas un certain nombre de renseignements concernant le mode de sécr

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Wilson, Charlotte F. "Inhibitory neurohumoral control of pancreatic exocrine secretion and gallbladder motility." Thesis, University of Sunderland, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297132.

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