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Dissertations / Theses on the topic 'Peptides – Analysis'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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1

Grail, Barry Mark. "Molecular recognition of peptides." Thesis, Bangor University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248898.

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2

Siu, Shiu-on, and 蕭紹安. "Biological mass spectrometry of peptides and glycopeptides." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40203372.

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3

Foster, Michael Scott. "Design, synthesis, kinetic analysis, molecular modeling, and pharmacological evaluation of novel inhibitors of peptide amidation." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/31816.

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Thesis (Ph.D)--Chemistry and Biochemistry, Georgia Institute of Technology, 2009.<br>Committee Chair: Dr. Sheldon W. May; Committee Member: Dr. James C. Powers; Committee Member: Dr. Nicholas Hud; Committee Member: Dr. Niren Murthy; Committee Member: Dr. Stanley H. Pollock. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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4

Xu, Minjie, and 许敏洁. "Dissociation and characterization of cationic radical peptides." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/197123.

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Gas phase fragmentations of cationic radical peptides provide important fundamental information that forms the basis for peptide sequencing by using mass spectrometry. Presenting results from low-energy collision-induced dissociation (CID) experiments and theoretical density functional theory (DFT) calculations in conjunction with Rice–Ramsperger–Kassel–Marcus modeling, this thesis describes some of the chemical properties, including the locations of the charge and radical sites that determine the gas-phase chemistry of peptide radical cations. The first Section (3.1) documents the dissocia

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5

Coffey, Jonathan A. "Mass spectrometric analysis of selected proteins and peptides." Thesis, University of Warwick, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246785.

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6

Lam, Ngor-wai, and 林我威. "Generation and characterization of cationic and anionic radical peptides." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B37097672.

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7

Karlsson, Katarina Flemmer. "Synthesis, conformational analysis, and biological evaluation of peptides from E. coli P pilus proteins." Lund : Organic Chemistry 2, Lund Institute of Technology, Lund University, 1997. http://catalog.hathitrust.org/api/volumes/oclc/39777038.html.

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8

Orback, Beatrice. "ELISA analysis of peptides and proteins in stabilized plasma." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-154064.

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9

Pinto, Devanand Michael. "Trace analysis of peptides and proteins by capillary electrophoresis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ34822.pdf.

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10

Zhang, Ruowen. "Isolation and analysis of antimicrobial peptides from frog skins." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534592.

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11

Pitkeathly, Maureen C. "The synthesis and conformational analysis of mitochondrial targeting peptides." Thesis, University of Edinburgh, 1991. http://hdl.handle.net/1842/12781.

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The thesis discusses protein targeting within cells, and in particular targeting to the mitochondrion. The synthesis and conformational analysis by CD and NMR of a mitochondrial targeting presequence peptide, and a non-functional deletion peptide are described. The intramitochondrial sorting of proteins is also discussed and investigated. Ch. 1 reviews the currently available knowledge of the mechanisms and factors involved in protein targeting. Ch. 2 describes the synthesis and purification of the 25 residue peptide corresponding to the mitochondrial targeting presequence of subunit IV of yea

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12

Bradford, Adrian Morley. "The characterisation and fragmentation of peptides by mass spectrometry /." Title page, contents and abstract only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09phb799.pdf.

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13

Song, Tao, and 宋涛. "Gas-phase formation, isomerization and dissociation of peptide radicalcations: energetics, dynamics, and mechanisms." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B47869550.

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Understanding the dissociation of odd-electron peptide radical cations is of great importance for the analytical applications of biological mass spectrometry because their diverse array of fragmentation pathways provides structural information to supplement that from even-electron protonated peptides—allowing peptide sequencing and, ultimately, protein identification. Nevertheless, the mechanisms of peptide radical formation and dissociation remain largely unexplored. In the studies reported in this Thesis, peptide radical cations (M?+) were generated through one-electron transfer (ET) in c

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14

Ng, Chun-ming Dominic, and 伍俊明. "Formation, isomerization and dissociation of radical cationicpeptides." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47145663.

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A fundamental understanding of the isomerization and fragmentation of peptide ions forms the scientific basis underlying peptide sequencing in the gas phase—an important emerging analytical technique routinely used in proteomics applications. Gas phase dissociation of odd-electron radical peptide cations (M?+) provides an alternative and complementary analytical method for identifying peptide sequences; this fragmentation behavior is distinct from that of even-electron protonated peptides ([M+H]+). Despite recent experimental and theoretical advances in studies of radical cationic peptides, t

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15

Xiang, Jie. "Functional genomic study and bioinformatic analysis on natural bioactive peptides." Thesis, Queen's University Belfast, 2017. https://pure.qub.ac.uk/portal/en/theses/functional-genomic-study-and-bioinformatic-analysis-on-natural-bioactive-peptides(4c3d14a3-7484-463b-8c82-cdc9abc5052e).html.

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An extraordinary diverse components of animal toxins have emerged along with the long-term evolution of animals, which have unique functions that protect them to survive in the wild. Specifically, the granular glands of amphibians contain multiple chemical compounds, among which, peptides are one of the major types of the constituents. This thesis is divided into six chapters. Chapter 1, as general introduction, describes the detailed background on peptide-based therapeutic agents, the promising therapeutic application of animal toxins, and a brief review on anuran skins and their secretions.

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16

Hayteas, David Lawrence. "HPLC analysis of myoglobin tryptic peptides from selected species of cetaceans." PDXScholar, 1990. https://pdxscholar.library.pdx.edu/open_access_etds/4086.

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Due to the large gaps in the fossil record, the evolutionary history of the mammalian order Cetacea is incomplete and controversial. Increasingly researchers are utilizing molecular and biochemical procedures to supplement cetacean paleontology. One of these methods is the comparison of amino acid sequences of myoglobin among species of this order. since this method is time-consuming and expensive, an alternative procedure is desirable.

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17

Kobayashi, Yuka. "Structural and Functional Analysis of Iron Ion-Coordinating Cyclic Peptides." Kyoto University, 2018. http://hdl.handle.net/2433/232327.

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18

Yan, Fu. "Detailed analysis of sequence requirements within 2A translational recoding peptides." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2654.

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2A sequences are short 20 ~30 amino acid peptides initially characterised from foot and mouth disease virus (FMDV), but also encoded in a range of Picornaviruses and other viruses as well as non-LTR retrotransposons in a broad range of organisms. They direct a translational recoding event in which ribosomes that have reached the final codon of the 2A sequence pause and terminate translation in the absence of a stop codon and then restart translation. The effect is to separate a single ORF into 2 polypeptides, between the final 2 amino acids (glycine and proline) of 2A, ‘skipping’ a peptide bon

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19

Vezenkov, Lubomir. "Synthesis, biological and structural analysis of organized biomimetic systems." Thesis, Montpellier 1, 2011. http://www.theses.fr/2011MON13502/document.

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Le passage des médicaments a travers la membrane cellulaire représente souvent une limitation majeur dans un grand nombre de thérapies (anti-cancéreuse, anti-virale par exemple). Des peptides vecteurs connus comme les CPPs (cell penetrating peptides) ont été utilises avec succès pour introduire a l’intérieur des cellules diverses molécules (protéines, peptides, siRNA, quantum dots) et présentent un fort potentiel dans l'adressage de médicaments. Parmi les différents CPPs décrits dans la littérature la plupart sont des peptides basiques ou amphiphiles.Nous nous sommes intéressés a l'utilisation

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20

Zheng, Huiru. "New algorithms for the analysis of mass spectral profiles from amphibian data." Thesis, University of Ulster, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272069.

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21

Mauk, Andrew W. "Determination of the structure of the magainin II transmembrane channel." Diss., Georgia Institute of Technology, 1999. http://hdl.handle.net/1853/11708.

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22

Crosby, Steven Robert. "Development and application of monoclonal antibodies to ACTH related peptides." Thesis, University of Manchester, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328332.

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23

Eriste, Elo. "Purification, structure and function of bioactive peptides /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-853-X/.

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24

Raghoonanan, Venisha. "Molecular characterization and in vitro functional analysis of putative immunoprotective molecules in the soft tick, Ornithodoros savignyi." Diss., University of Pretoria, 2010. http://hdl.handle.net/2263/29182.

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Since ticks are classified as hematophagous ectoparasites, the primary feeding event involves a bloodmeal on a vertebrate host. Such activities facilitate the ingestion of microorganisms which may be detrimental to the survival of a tick. It is observed, however, that ticks are able to survive such invasion by microorganisms and in several cases, facilitate the transmission of pathogens, while themselves remaining unaffected. This phenomenon is attributed to the innate immune system of ticks. The focus of this project is on stimulus-induced immunoreactive peptides known as antimicrobial peptid

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25

Ossipova, Elena. "Methods for mass spectrometric proteome analysis /." Uppsala : Dept. of Chemistry, Swedish University of Agricultural Sciences, 2008. http://epsilon.slu.se/200809.pdf.

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26

Gu, Binghe. "Development of Polymer Monoliths for the Analysis of Peptides and Proteins." BYU ScholarsArchive, 2006. https://scholarsarchive.byu.edu/etd/1296.

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Several novel polymer monoliths for the analysis of peptides and proteins were synthesized using polyethylene glycol diacrylate (PEGDA) as crosslinker. Photo-initiated copolymerization of polyethylene glycol methyl ether acrylate and PEGDA yielded an inert monolith that could be used for size exclusion liquid chromatography of peptides and proteins. This macroscopically uniform monolith did not shrink or swell in either water or tetrahydrofuran. More importantly, it was found to resist adsorption of both acidic and basic proteins in aqueous buffer without any organic solvent additives. A stron

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27

Sargaeva, Nadezda P. "Deamidation and related problems in structural analysis of peptides and proteins." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12612.

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Thesis (Ph.D.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Electron capture dissociation (ECD) and electron transfer dissociation (ETD) can generate unique fragments and preserve post-translational modifications (PTMs), enabling their detection in biological samples. T

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28

Orwar, Owe. "Laser-based ultra-trace analysis in liquid chromatography determination of neuroactive amino acids and peptides /." Göteborg : Dept. of Analytical and Marine Chemistry, University of Göteborg, 1994. http://catalog.hathitrust.org/api/volumes/oclc/39775021.html.

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29

Atzori, Alessio. "Conformational analysis of peptides and proteins for drug design using molecular simulations." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/conformational-analysis-of-peptides-and-proteins-for-drug-design-using-molecular-simulations(050ba296-a4c4-4a5b-87bf-66d90f7ddc5a).html.

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The intrinsic plasticity of biological systems provides opportunities for rational design of selective and potent ligands. Increasingly, computational methods are being applied to predict biomolecular flexibility. However, the motions involved in these processes can be large and occur on time scales generally difficult to achieve with standard simulation methods. In order to overcome the intrinsic limitations of classical molecular dynamics, this Ph.D. project focuses on the application of advanced sampling computational techniques to capture the plasticity of diverse biological systems. The f

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30

Wallis, Anne Elizabeth. "Identification of Leishmania genes encoding proteins containing tandemly repeating peptides." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/29447.

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In order to identify Leishmania proteins which may be immunologically relevant or may play a role in interactions between Leishmania and its mammalian host, a Leishmania major genomic DNA library was constructed in the vector λgt11 and screened with antibodies raised to Leishmania major promastigote membranes. Two recombinant DNA clones were identified which encoded repetitive sequences (Clone 20 and Clone 39). Clone 20 encoded a repetitive peptide of 14 amino acids and clone 39 encoded an unrelated repetitive peptide of 10 amino acids. Analysis of one of these clones, Clone 20, indicated that

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31

Norberg, Åke. "Isolation and characterization of regulatory peptides and bioactive compounds /." Stockholm : Karolinska institutet, 2004. http://diss.kib.ki.se/2004/91-7349-882-3/.

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32

Li, Yun. "Development of Biocompatible Polymer Monoliths for the Analysis of Proteins and Peptides." Diss., CLICK HERE for online access, 2009. http://contentdm.lib.byu.edu/ETD/image/etd3161.pdf.

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33

Redeby, Theres. "Improved Techniques for Protein Analysis Focusing on Membrane Proteins and Hydrophobic Peptides." Doctoral thesis, Stockholm, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-617.

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34

Hein, Renee Joy. "LC-MS analysis of related peptides and anions in the positive mode." [Ames, Iowa : Iowa State University], 2008.

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35

Smith, K. I. "The two-dimensional nuclear magnetic resonance spectroscopy analysis of peptides in solution." Thesis, University of Manchester, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377720.

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36

Kukwikila, M. N. "Synthesis of nucleoside analogues and peptides for nanoore analysis and controlled bioactivity." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1402763/.

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This research describes the synthesis of nucleoside analogues and peptides, and their application to nanopore technology and cell biology. Nanopore technology is a technique in which analytes are detected by disturbances in ionic current caused as they traverse a pore, at a fixed applied potential. Here potential applications of the technology are explored. A nanopore-based method to detect enzymatic activity was investigated. The technique involved the detection of peptide fragments proteolytically released from a solid-support. The released fragments gave rise to distinct electrical signals

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37

Aiello, G. "NUTRITIONAL PEPTIDOMICS: DISCOVERY, QUANTIFICATION, AND FUNCTIONAL ANALYSIS OF PLANT PROTEIN DERIVED PEPTIDES." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/540245.

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NUTRITIONAL PEPTIDOMICS: DISCOVERY, QUANTIFICATION, AND FUNCTIONAL ANALYSIS OF PLANT PROTEIN DERIVED PEPTIDES Sector CHIM/10 - Food chemistry Introduction and aims of thesis The study of bioactive peptides is a central issue in the development of innovative therapies. The increased attention for fresher and ‘greener’ foods and nutraceuticals possessing health-preventing or health-promoting properties makes bioactive peptides suitable candidates for a new era of pharmaceutical products. Analysing and understanding nature and bioactivity of nutritional peptides, typically delivered from p

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38

Hagarman, Andrew Michael Schweitzer-Stenner Reinhard. "Conformations of unfolded and partially folded peptides and proteins probed by optical spectroscopy /." Philadelphia, Pa. : Drexel University, 2010. http://hdl.handle.net/1860/3313.

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39

Ye, Xiadi. "Genetic analysis of natriuretic peptides and blood pressure in the spontaneously hypertensive rat /." [St. Lucia, Qld.], 2000. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16801.pdf.

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40

Haileselassie, Seble Sereke Berhan. "Production of enzyme-modified cheese and bioactive peptides by Lactobacillus and commercial enzymes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ50782.pdf.

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41

Nowak, Cheryl L. "Design, synthesis, and evaluation of bicyclic peptides as ammonium ionophores." Link to electronic thesis, 2003. http://www.wpi.edu/Pubs/ETD/Available/etd-0428103-180827/.

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Thesis (M.S.)--Worcester Polytechnic Institute.<br>Keywords: solution 13C-NMR study; olid phase peptide synthesis; bicyclic peptides; ammonium ionophores; valinomycin; ion selective electrode. Includes bibliographical references (p. 63-65).

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42

Kollappillil, Somakumar Krishnakumar. "Synthesis and analysis of puromycin analogues and amphiphilic peptidyl-RNA conjugates." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10086.

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Une étude récente sur le transfert peptidique pH dépendant effectuée avec divers ARNt aminoacyles a révélé la dépendance au pH du transfert peptidique. L’instabilité hydrolytique rend impossible l’obtention de la valeur expérimentale du pKa de l’eau donné pour le groupement α-amino des esters 3'-aminoacyladenosine. Comme les analogues de la puromycine sont les analogues les plus proches du 3’-terminal des ARNt aminoacyles et qu’ils contiennent une liaison amide stable en position 3’, il est intéressant de déterminer la valeur du pKa du groupement α-amino de différents analogues de la puromycin

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43

Perraudeau, Mohini. "The development and analysis of H2-O deficient mice." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325169.

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44

Mercer, Eric Alexander John. "Expression, characterisation and structural analysis of the putative slow voltage-dependent potassium channel minK." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243623.

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45

Zhang, Le. "Advances in capillary electrophoresis analysis of lipids, proteins, and peptides with laser-induced fluorescence /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/8529.

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46

Pirani, Parisa. "Surface-Engineered Magnetic Nanoparticles for Sample Preparation and Analysis of Proteins and Peptides." ScholarWorks@UNO, 2015. http://scholarworks.uno.edu/td/2012.

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Sample preparation as an essential step in mass spectrometry-based analysis, plays a critical role in proteomics studies. Magnetic nanoparticles (MNPs) have been widely used in protein and peptide sample preparation due to their magnetic properties, biocompatibility, easy synthesis and surface functionalization. MNPs loaded with analyte or analyte modification reagent can be easily separated from the reaction medium by an externally applied magnetic field. The small size of MNPs provides high analyte loading and extraction capacity. Additionally, MNP can be decorated with different functional

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47

Gomes, Carolina Nogueira Carvalho. "Production and analysis of pharmaceutically relevant peptides in Lactuca sativa and Medicago truncatula." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/21655.

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Mestrado em Biotecnologia Alimentar<br>O molecular pharming permite a produção de proteinas terapêuticas recombinantes a larga escala, de forma segura e a baixo custo. No presente trabalho, é proposta a produção heteróloga de quatro péptidos inibidores da ACE em dois emergentes sistemas de expressão vegetal, Lactuca sativa (alface) e Medicago truncatula (luz cortada). A utilização da alface, uma planta comestível, pode proporcionar um meio para a administração oral de péptidos anti-hipertensivos, criando um novo alimento funcional. Por outro lado, a utilização de M. truncatula, uma le

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48

Abello, Nicolas. "Chemical labeling for the analysis of proteins, peptides and metabolites by mass spectrometry." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2009. http://irs.ub.rug.nl/ppn/318.

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49

Cao, Ping. "Mass spectrometric analysis of amino acids, peptides, and proteins in complex biological mixtures /." Digital version accessible at:, 1998. http://wwwlib.umi.com/cr/utexas/main.

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50

Yeung, Man-lung, and 楊文龍. "Proteolytic cleavage of PDZD2 generates a secreted peptide containing two PDZ domains." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31245055.

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