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Journal articles on the topic 'Peptides du soi'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Laouar, Y., and C. Viret. "Développement intrathymique des lymphocytes T : le rôle des peptides du soi dans le processus de sélection positive." médecine/sciences 15, no. 12 (1999): 1401. http://dx.doi.org/10.4267/10608/1283.

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2

Feng, Jue-Ping, Ru Zhu, Fagang Jiang, et al. "Correction: Melittin-encapsulating peptide hydrogels for enhanced delivery of impermeable anticancer peptides." Biomaterials Science 8, no. 21 (2020): 6100. http://dx.doi.org/10.1039/d0bm90081h.

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Correction for ‘Melittin-encapsulating peptide hydrogels for enhanced delivery of impermeable anticancer peptides’ by Jue-Ping Feng et al., Biomater. Sci., 2020, 8, 4559–4569, DOI: 10.1039/C9BM02080B.

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Jia, X., J. C. Brown, Y. N. Kwok, R. A. Pederson, and C. H. S. McIntosh. "Gastric inhibitory polypeptide and glucagon-like peptide-1(7–36) amide exert similar effects on somatostatin secretion but opposite effects on gastrin secretion from the rat stomach." Canadian Journal of Physiology and Pharmacology 72, no. 10 (1994): 1215–19. http://dx.doi.org/10.1139/y94-172.

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Previous studies on the isolated perfused stomach have shown that gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1(7–36) amide (GLP-1(7–36) amide) stimulate release of somatostatin (somatostatin-like immunoreactivity, SLI). GIP produced a paradoxical increase in gastrin secretion, whereas GLP-1(7–36) was inhibitory. In the current study, the actions of synthetic (sp) and native (np) porcine and synthetic human (sh) GIP, G LP-1(7–36), and GLP-1(7–37) on SLI and gastrin secretion were compared using a gradient perfusion of peptide. All peptides increased SLI secretion at a thresh

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4

Brinkworth, Craig S., Tara L. Pukala, John H. Bowie, and Michael J. Tyler. "Host Defence Peptides from the Skin Glands of Australian Amphibians. Caerulein Neuropeptides and Antimicrobial, Anticancer, and nNOS Inhibiting Citropins from the Glandular Frog Litoria subglandulosa." Australian Journal of Chemistry 57, no. 7 (2004): 693. http://dx.doi.org/10.1071/ch03325.

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The host defence peptides from the skin secretions of the Australian Glandular Frog (Litoria subglandulosa) are similar to those of the closely related species Litoria citropa. Both species produce several potent caerulein neuropeptides and antimicrobial- and anticancer-active citropin peptides. The major neuropeptides from Litoria subglandulosa are caerulein 1.1 [pGlu Gln Asp Tyr(SO3) Thr Gly Trp Met Asp Phe–NH2], caerulein 1.2 [pGlu Gln Asp Tyr(SO3) Thr Gly Trp Phe Asp Phe–NH2], and caerulein 2.1 [pGlu Gln Asp Tyr(SO3) Thr Gly Ala His Met Phe–NH2], all of which are smooth muscle active. The

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Ghei, Monica, David F. Stroncek, and Maurizio Provenzano. "Analysis of Memory T Lymphocytes Activity Following Stimulation with HLA-A24, A1 and Cw4 Restricted 9- and 10-mer Cytomegalovirus pp65 Overlapping Peptides." Blood 104, no. 11 (2004): 2876. http://dx.doi.org/10.1182/blood.v104.11.2876.2876.

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Abstract In healthy subjects, primary infection with Cytomegalovirus (CMV) is usually mild or asymptomatic and is effectively controlled by the cell-mediated immune response. However, in immune compromised individuals, such as those with AIDS or after bone marrow transplantation, CMV reactivation is associated with significant morbidity until the individual’s immune system is completely reconstituted. One means of preventing post-transplant CMV infection is adoptive immunotherapy using CMV-specific cytotoxic T cells (CTLs) from the transplant donor. Several 9- and 10-mer HLA class I restricted

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Andresen, Louise C., Anna-Karin Björsne, Samuel Bodé, Leif Klemedtsson, Pascal Boeckx, and Tobias Rütting. "Simultaneous quantification of depolymerization and mineralization rates by a novel <sup>15</sup>N tracing model." SOIL 2, no. 3 (2016): 433–42. http://dx.doi.org/10.5194/soil-2-433-2016.

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Abstract. The depolymerization of soil organic matter, such as proteins and (oligo-)peptides, into monomers (e.g. amino acids) is currently considered to be the rate-limiting step for nitrogen (N) availability in terrestrial ecosystems. The mineralization of free amino acids (FAAs), liberated by the depolymerization of peptides, is an important fraction of the total mineralization of organic N. Hence, the accurate assessment of peptide depolymerization and FAA mineralization rates is important in order to gain a better process-based understanding of the soil N cycle. In this paper, we present

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Price, Paul A., Houston R. Tanner, Brett A. Dillon, Mohammed Shabab, Graham C. Walker, and Joel S. Griffitts. "Rhizobial peptidase HrrP cleaves host-encoded signaling peptides and mediates symbiotic compatibility." Proceedings of the National Academy of Sciences 112, no. 49 (2015): 15244–49. http://dx.doi.org/10.1073/pnas.1417797112.

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Legume–rhizobium pairs are often observed that produce symbiotic root nodules but fail to fix nitrogen. Using the Sinorhizobium meliloti and Medicago truncatula symbiotic system, we previously described several naturally occurring accessory plasmids capable of disrupting the late stages of nodule development while enhancing bacterial proliferation within the nodule. We report here that host range restriction peptidase (hrrP), a gene found on one of these plasmids, is capable of conferring both these properties. hrrP encodes an M16A family metallopeptidase whose catalytic activity is required f

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Jørgensen, Nicolai Grønne, Shamaila Munir Ahmad, Niels Abildgaard, et al. "Peptide vaccination against multiple myeloma using peptides derived from anti-apoptotic proteins: a phase I trial." Stem Cell Investigation 3 (December 23, 2016): 95. http://dx.doi.org/10.21037/sci.2016.11.09.

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9

Wang, Shu Jing, Jia Liu, Fei Wang, et al. "Tumstatin 7 Peptide Affect Biological Activity of B16 Melanoma Cell." Advanced Materials Research 641-642 (January 2013): 915–18. http://dx.doi.org/10.4028/www.scientific.net/amr.641-642.915.

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To study the effect of biological activity of Tumstatin 7 peptide on the cell proliferation and apoptosis of B16 melanoma. Tumstatin 7 peptide was synthesized and its purity is 98.4532% by high-performance liquid chromatography. The effect of 7 peptide on B16 melanoma was observed by MTT, cell growth curve, the observation of the transmission electron microscope (TEM). 7 peptide can significantly inhibit B16 melanoma cell proliferation, showing dose- and time-dependent .Its IC50 was 72.53 μg/ml.The morphology of B16 melanoma cell was obviously changed by TEM, such as karyopyknosis and apoptoti

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10

Vincent, Martin J., Angela J. Sanchez, Bobbie R. Erickson, et al. "Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Proteolytic Processing by Subtilase SKI-1." Journal of Virology 77, no. 16 (2003): 8640–49. http://dx.doi.org/10.1128/jvi.77.16.8640-8649.2003.

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ABSTRACT Crimean-Congo hemorrhagic fever (CCHF) virus is a tick-borne member of the genus Nairovirus, family Bunyaviridae. The mature virus glycoproteins, Gn and Gc (previously referred to as G2 and G1), are generated by proteolytic cleavage from precursor proteins. The amino termini of Gn and Gc are immediately preceded by tetrapeptides RRLL and RKPL, respectively, leading to the hypothesis that SKI-1 or related proteases may be involved (A. J. Sanchez, M. J. Vincent, and S. T. Nichol, J. Virol. 76:7263-7275, 2002). In vitro peptide cleavage data show that an RRLL peptide representing the Gn

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TORRES, Allan M., Xiuhong WANG, Jamie I. FLETCHER, et al. "Solution structure of a defensin-like peptide from platypus venom." Biochemical Journal 341, no. 3 (1999): 785–94. http://dx.doi.org/10.1042/bj3410785.

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Three defensin-like peptides (DLPs) were isolated from platypus venom and sequenced. One of these peptides, DLP-1, was synthesized chemically and its three-dimensional structure was determined using NMR spectroscopy. The main structural elements of this 42-residue peptide were an anti-parallel β-sheet comprising residues 15-18 and 37-40 and a small 310 helix spanning residues 10-12. The overall three-dimensional fold is similar to that of β-defensin-12, and similar to the sodium-channel neurotoxin ShI (Stichodactyla helianthusneurotoxin I). However, the side chains known to be functionally imp

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Mendoza, S. A., J. A. Schneider, A. Lopez-Rivas, J. W. Sinnett-Smith, and E. Rozengurt. "Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. II. Changes in Na+ and Ca2+ fluxes, Na+/K+ pump activity, and intracellular pH." Journal of Cell Biology 102, no. 6 (1986): 2223–33. http://dx.doi.org/10.1083/jcb.102.6.2223.

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The amphibian tetradecapeptide, bombesin, and structurally related peptides caused a marked increase in ouabain-sensitive 86Rb+ uptake (a measure of Na+/K+ pump activity) in quiescent Swiss 3T3 cells. This effect occurred within seconds after the addition of the peptide and appeared to be mediated by an increase in Na+ entry into the cells. The effect of bombesin on Na+ entry and Na+/K+ pump activity was concentration dependent with half-maximal stimulation occurring at 0.3-0.4 nM. The structurally related peptides litorin, gastrin-releasing peptide, and neuromedin B also stimulated ouabain-se

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13

McIntosh, C. H., X. Jia, and Y. N. Kowk. "Characterization of the opioid receptor type mediating inhibition of rat gastric somatostatin secretion." American Journal of Physiology-Gastrointestinal and Liver Physiology 259, no. 6 (1990): G922—G927. http://dx.doi.org/10.1152/ajpgi.1990.259.6.g922.

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The opioid peptides are potent inhibitors of gastric somatostatin-like immunoreactivity (SLI) secretion from the isolated perfused rat stomach. In addition, inhibition of SLI secretion induced by vagal stimulation is partially blocked by naloxone, indicating that endogenously released opioid peptides probably play a physiological role in the regulation of SLI release. The opioid peptides exert their effects by interacting with a number of different receptor types. In the present study, the effect of the selective delta-opioid receptor agonists [D-Pen2.5]enkephalin and [D-Pen2,L-Pen5]enkephalin

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14

Larson, Richard S., David C. Brown, Chunyan Ye та Brian Hjelle. "Peptide Antagonists That Inhibit Sin Nombre Virus and Hantaan Virus Entry through the β3-Integrin Receptor". Journal of Virology 79, № 12 (2005): 7319–26. http://dx.doi.org/10.1128/jvi.79.12.7319-7326.2005.

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ABSTRACT Specific therapy is not available for the treatment of hantavirus cardiopulmonary syndrome caused by Sin Nombre virus (SNV). The entry of pathogenic hantaviruses into susceptible human cells is dependent upon expression of the αvβ3 integrin, and transfection of human β3 integrin is sufficient to confer infectibility onto CHO (Chinese hamster ovary) cells. Furthermore, pretreatment of susceptible cells with anti-β3 antibodies such as c7E3 or its Fab fragment ReoPro prevents hantavirus entry. By using repeated selection of a cyclic nonamer peptide phage display library on purified αvβ3,

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15

Karmańska, Aleksandra, and Bolesław Karwowski. "Lunazine - biologically active peptide from soybean." Farmacja Polska 76, no. 9 (2020): 493–99. http://dx.doi.org/10.32383/farmpol/128611.

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16

Tagmyer, Tara L., Jodi K. Craigo, Sheila J. Cook, Deborah L. Even, Charles J. Issel, and Ronald C. Montelaro. "Envelope Determinants of Equine Infectious Anemia Virus Vaccine Protection and the Effects of Sequence Variation on Immune Recognition." Journal of Virology 82, no. 8 (2008): 4052–63. http://dx.doi.org/10.1128/jvi.02028-07.

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ABSTRACT A highly effective attenuated equine infectious anemia virus (EIAV) vaccine (EIAVD9) capable of protecting 100% of horses from disease induced by a homologous Env challenge strain (EIAVPV) was recently tested in ponies to determine the level of protection against divergent Env challenge strains (J. K. Craigo, B. S. Zhang, S. Barnes, T. L. Tagmyer, S. J. Cook, C. J. Issel, and R. C. Montelaro, Proc. Natl. Acad. Sci. USA 104:15105-15110, 2007). An inverse correlation between challenge strain Env variation and vaccine protection from disease was observed. Given the striking differences i

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Xin, Hong, and Jim E. Cutler. "Vaccine and Monoclonal Antibody That Enhance Mouse Resistance to Candidiasis." Clinical and Vaccine Immunology 18, no. 10 (2011): 1656–67. http://dx.doi.org/10.1128/cvi.05215-11.

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ABSTRACTPreviously we showed that antibodies specific for the glycan β-1,2-mannotriose [β-(Man)3] on the cell surface ofCandida albicansprotect mice against disseminated candidiasis (H. Xin, S. Dziadek, D. R. Bundle, and J. E. Cutler, Proc. Natl. Acad. Sci. U. S. A. 105:13526–13531, 2008). Furthermore, six 14-mer peptides that are within the N-terminal portion ofC. albicanswall proteins were conjugated to the glycan in an attempt to create immunogenic glycopeptide conjugates. By a dendritic cell (DC)-based immunization approach, all were immunogenic and three of the six conjugates induced a hi

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18

Zachary, I., J. W. Sinnett-Smith, and E. Rozengurt. "Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. I. Activation of protein kinase C and inhibition of epidermal growth factor binding." Journal of Cell Biology 102, no. 6 (1986): 2211–22. http://dx.doi.org/10.1083/jcb.102.6.2211.

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Addition of bombesin to quiescent cultures of Swiss 3T3 cells caused a rapid increase in the phosphorylation of an Mr 80,000 cellular protein (designated 80k). The effect was both concentration and time dependent; enhancement in 80k phosphorylation could be detected as early as 10 s after the addition of peptide. Recently, a rapid increase in the phosphorylation of an 80k cellular protein after treatment with phorbol esters or diacylglycerol has been shown to reflect the activation of protein kinase C in intact fibroblasts (Rozengurt, E., A. Rodriguez-Pena, and K. A. Smith, 1983, Proc. Natl. A

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19

Goetinck, P. F., N. S. Stirpe, P. A. Tsonis, and D. Carlone. "The tandemly repeated sequences of cartilage link protein contain the sites for interaction with hyaluronic acid." Journal of Cell Biology 105, no. 5 (1987): 2403–8. http://dx.doi.org/10.1083/jcb.105.5.2403.

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The ternary complex involving link protein (LP), proteoglycan monomer, and hyaluronic acid (HA) is an important component of the extracellular matrix of cartilage. LP contains tandemly repeated sequences that were tested for their ability to interact with HA. A solid-phase assay was developed in which LP could specifically bind to immobilized HA. Detection of LP was by means of an antiserum directed against a peptide from the NH2-terminal half of LP. LP binding to HA could be inhibited with mAb 8A4 (Caterson, B., J. R. Baker, J. E. Christner, Y. Lee, and M. Lentz. 1985. J. Biol. Chem. 260:1134

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Igari, Atsuko, Takanori Moriki, Terumichi Nakagawa, Yusuke Yamaguchi, and Mitsuru Murata. "Functional Analysis of a Peptide Sequence (Thr323 - Cys337) In ADAMTS13 Disintegrin-Like Domain Revealed Two Discontinuous Sequences Involved In the Interaction with VWF." Blood 116, no. 21 (2010): 2200. http://dx.doi.org/10.1182/blood.v116.21.2200.2200.

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Abstract Abstract 2200 ADAMTS13 specifically cleaves multimeric von Willebrand factor (VWF) into smaller molecules to reduce its high reactivity with platelets. The disintegrin-like (D) domain, adjacent to the catalytic domain of ADAMTS13, plays an important role in the process of VWF cleavage. In this study, we aimed to elucidate critical peptide sequences in D-domain involved in the interaction with VWF. A series of partially overlapping peptide sequences, approximately 20 amino acids in length, covering the D-domain, were synthesized and the inhibitory effects on the catalytic activity of p

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Reichelt, Karl L., Paul D. Edminson, and Kim G. Toft. "Urinary peptides in schizophrenia and depression." Stress Medicine 1, no. 3 (1985): 169–81. http://dx.doi.org/10.1002/smi.2460010307.

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22

Sarfati, Patrice D., Gary M. Green, Paul Brazeau, and Jean Morisset. "Presence of somatostatin-like immunoreactivity in rat pancreatic juice: a physiological phenomenon." Canadian Journal of Physiology and Pharmacology 64, no. 5 (1986): 539–44. http://dx.doi.org/10.1139/y86-089.

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These studies were performed to assess the effects of various exocrine pancreatic stimuli on somatostatin-like immunoreactivity (SLI) secretion in pure rat pancreatic juice. Ingestion of a meal and subcutaneous injections of caeruiein (CA), secretin (SE), and their combination (CA + SE) were compared. Basal fasting SLI output over 5½ h averaged 13.7 ng/30 min; the response to feeding resulted in decreased SLI outputs from 9.7 to 1.7 ng/30 min, a reduction of 81%. SLI secretion following CA, SE, and CA + SE was similar to that obtained following feeding but the reductions of 29, 32, and 39% wer

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ABDURRAHMAN, SYED, REDA KABLI, and ABDULLAH EL-TAHIR. "Synthesis of Some Peptides." Journal of King Abdulaziz University-Science 1, no. 1 (1989): 161–67. http://dx.doi.org/10.4197/sci.1-1.13.

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Ruiz Álvarez, J. I., J. M. Teijeiro, A. R. Charmandarian, J. P. Haumüller, and P. E. Marini. "142 DESIGN OF ANTIBODIES SPECIFIC FOR PEPTIDES PRESENT EXCLUSIVELY IN DIFFERENT MEMBERS OF THE PREGNANCY ASSOCIATED GLYCOPROTEINS FAMILY." Reproduction, Fertility and Development 22, no. 1 (2010): 230. http://dx.doi.org/10.1071/rdv22n1ab142.

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Accurate diagnosis of non-pregnancy and prompt re-enlistment of cattle into an appropriate breeding protocol are essential components of successful reproductive programs. The search for biochemical markers of early pregnancy has led to the characterization of the pregnancy-associated glycoproteins (PAG), a large family expressed exclusively in the placenta. In cattle, the PAG family is composed of at least 22 translated genes, with different spatiotemporal expression (Telugu B. et al. 2009 BMC Genomics 10, 185). The PAG may be detected in placenta and some members have been detected in serum b

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Kemball-Cook, G., S. J. Edwards, K. Sewerin, L. O. Anderson, and T. W. Barrowcliffe. "Factor VIII Procoagulant Protein Interacts with Phospholipid Vesicles Via its 80 kDa Light Chain." Thrombosis and Haemostasis 60, no. 03 (1988): 442–46. http://dx.doi.org/10.1055/s-0038-1646987.

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SummaryIn a previous report, we detailed the fractionation of polyclonal human anti-Factor VIII :C into a component directed exclusively against the phospholipid-binding site on Factor VIII (PL-site antibody) and another directed at other sites (non-PL-site antibody). The location on the F.VIII molecule of its PL-binding site has now been studied by two different methods using this fractionated 125I-labelled anti-F.VIII: C Fab’.The first method was modified from that of Weinstein et al. (Proc Natl Acad Sci USA 1981; 78: 5137-41), involving electrophoresis of F.VIII peptide-125I-Fab‘ A/F.VIII i

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Montgomery, Lynnette R., and Charles H. Hubscher. "Altered vasopressin and natriuretic peptide levels in a rat model of spinal cord injury: implications for the development of polyuria." American Journal of Physiology-Renal Physiology 314, no. 1 (2018): F58—F66. http://dx.doi.org/10.1152/ajprenal.00229.2017.

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Urinary dysfunction is a common complaint following spinal cord injury (SCI) and is a leading issue for individuals with SCI that impacts their quality of life. One urinary complication that has received little attention is SCI-induced polyuria, even though individuals with SCI will significantly restrict their fluid intake to decrease urine production, leading to sequelae of medical complications. Understanding the mechanisms instigating the development of polyuria will allow us to target interventions that may alleviate polyuria symptoms, leading to significant improvements in the quality of

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Nagler, Adi, Shelly Kalaora, Deborah Gitta Rosenberg, et al. "672 Identification of microbial-derived HLA-bound peptides in melanoma." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A710. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0672.

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BackgroundThe query for tumor shared and neo-antigens as a therapeutic approach has been the focus of cancer immunology for the past two decades. Notably, these peptide sequences can bind to HLA molecules and present on the cell surface, subsequently to be recognized by T-cell receptors (TCRs), activating the immune system and so facilitating in tumor rejection.1–3 The search for new origins of targetable types of HLA peptides is consistently growing, and new studies show peptides that are derived from non-canonical open reading frames (ORFs), altered translation, proteasome splicing, viral pr

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He, P., A. Radunz, K. P. Bader, and G. H. Schmid. "Influence of CO2 and SO2 on Growth and Structure of Photosystem II of the Chinese Tung-Oil Tree Aleurites montana." Zeitschrift für Naturforschung C 51, no. 7-8 (1996): 441–53. http://dx.doi.org/10.1515/znc-1996-7-801.

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Three months old plants of the Chinese tung-oil tree Aleurites montana were cultivated for 4 months in air containing an increased amount of 700 ppm CO2. During the exposure to 700 ppm CO2 the plants exhibited a considerably stronger growth (30-40% ) in comparison to the control plants (grown in normal air). In these CO2-plants during the entire analyzing period the amount of soluble proteins, of soluble sugars and the chlorophyll content were lower than in control plants. The protein content, referred to leaf area, increased during this time in both plant types by approx. 50% but with a diffe

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Chen, Wenwei, Yao Hong, Zhenbao Jia, and Guangrong Huang. "Purification and Identification of Antioxidant Peptides from Hydrolysates of Large Yellow Croaker (Pseudosciaena crocea) Scales." Transactions of the ASABE 63, no. 2 (2020): 289–94. http://dx.doi.org/10.13031/trans.13693.

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HighlightsThree antioxidant peptides were efficiently obtained from large yellow croaker scales.The molecular weights of the three peptides were 879.4, 952.5, and 1070.4 Da, respectively.The large yellow croaker scales’ hydrolysates are a good source of natural antioxidants.Abstract. The scales of large yellow croaker () are typically discarded as waste during processing. In this study, three peptides with high antioxidant properties were purified from the scales via ultrafiltration and column chromatography. Through matrix-assisted laser desorption ionization/time-of-flight mass spectrometry,

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Sedlik, C., G. Dadaglio, M. F. Saron, et al. "In Vivo Induction of a High-Avidity, High-Frequency Cytotoxic T-Lymphocyte Response Is Associated with Antiviral Protective Immunity." Journal of Virology 74, no. 13 (2000): 5769–75. http://dx.doi.org/10.1128/jvi.74.13.5769-5775.2000.

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ABSTRACT Many approaches are currently being developed to deliver exogenous antigen into the major histocompatibility complex class I-restricted antigen pathway, leading to in vivo priming of CD8+ cytotoxic T cells. One attractive possibility consists of targeting the antigen to phagocytic or macropinocytic antigen-presenting cells. In this study, we demonstrate that strong CD8+ class I-restricted cytotoxic responses are induced upon intraperitoneal immunization of mice with different peptides, characterized as CD8+ T-cell epitopes, bound to 1-μm synthetic latex microspheres and injected in th

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Wong, Philip Ching Yat, Jun Guo, and Aidong Zhang. "The renal and cardiovascular effects of natriuretic peptides." Advances in Physiology Education 41, no. 2 (2017): 179–85. http://dx.doi.org/10.1152/advan.00177.2016.

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The landmark report by de Bold et al. in 1981 signified the heart as one of the endocrine organs involved in fluid and salt balance (de Bold AJ, Borenstein HB, Veress AT, Sonnenberg H. Life Sci 28: 89–94, 1981). Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are secreted from cardiomyocytes in response to cardiac stretch as in the case of heart failure, whereas C-type natriuretic peptide (CNP) is secreted from endothelial and renal cells in response to cytokines and endothelium-dependent agonists, such as acetylcholine. Binding ANP or BNP to natriuretic peptide receptor A

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Badea, Ana, François Eudes, Andre Laroche, et al. "Antimicrobial peptides expressed in wheat reduce susceptibility to Fusarium head blight and powdery mildew." Canadian Journal of Plant Science 93, no. 2 (2013): 199–208. http://dx.doi.org/10.4141/cjps2012-125.

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Badea, A., Eudes, F., Laroche, A., Graf, R., Doshi, K., Amundsen, E., Nilsson, D. and Puchalski, B. 2013. Antimicrobial peptides expressed in wheat reduce susceptibility to Fusarium head blight and powdery mildew. Can. J. Plant Sci. 93: 199–208. Antimicrobial peptides (AMPs) have a broad spectrum of action against bacteria, fungi and viruses, which makes them attractive for building plant defense against a diversity of pathogens. Peptides MsrA2 and 10R were cloned in three genetic constructs for tissue-specific expressions in wheat, using either Lem1, GstA1WIR1a, or Ltp6 and LTP6 signal peptid

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Diamond, Scott L. "Systems Biology to Predict Platelet Function." Blood 116, no. 21 (2010): SCI—38—SCI—38. http://dx.doi.org/10.1182/blood.v116.21.sci-38.sci-38.

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Abstract Abstract SCI-38 Systems Biology seeks to provide patient-specific prediction of dynamic cellular response to multiple stimuli, critical information toward predicting risk, disease progression, or response to therapy. We deployed two distinct approaches, bottom-up and top-down analyses, to gain insight into platelet signaling. The bottom-up approach required a definition of reaction network and kinetic equations (topology), kinetic parameters, and initial concentrations in order to simulate platelet signaling. We developed a computational platelet model – assembled from 24 peer-reviewe

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Kasper, Laura, Abbas Zein Al-Din, Jürgen Bruns, Rudolf Volkmer, and Klaus Petermann. "Fix-Wavelength Multi-Analyte Detection with Serial SOI Ring Resonators." Engineering Proceedings 6, no. 1 (2021): 22. http://dx.doi.org/10.3390/i3s2021dresden-10108.

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We present a method for the read-out of five serially arranged SOI ring resonator-based biosensors at a speed of 3 Hz/sensor and a fixed wavelength of 1550 nm. The system uses the high thermo-optical coefficient of silicon by applying AC voltages to periodically heat up electrodes adjacent to each sensor. A time-division multiplex scheme allows the allocation of the measured optical output from the mutual spectrum to each specific resonator. We demonstrate our system by immobilizing two different antibodies (biotin and a hexa-His-peptide) at the surface of selected resonators and successfully

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Nemeth, Elizabeta. "Development of Hepcidin Agonists and Antagonists." Blood 114, no. 22 (2009): SCI—27—SCI—27. http://dx.doi.org/10.1182/blood.v114.22.sci-27.sci-27.

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Abstract Abstract SCI-27 Hepcidin binding to its receptor, the iron exporter ferroportin, leads to degradation of the ligand-receptor complex and decreased flow of iron into plasma from duodenum, macrophages and hepatocytes. Dysregulated production of hepcidin or its aberrant interaction with ferroportin causes a number of iron disorders. Hepcidin deficiency, either relative or absolute, underlies excessive iron loading in hereditary hemochromatosis, beta-thalassemia and hepatitis C. A rare type of hereditary hemochromatosis is also caused by ferroportin resistance to hepcidin. On the other si

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Park, J., T. Chiba, K. Yokotani, J. DelValle, and T. Yamada. "Somatostatin receptors on canine fundic D-cells: evidence for autocrine regulation of gastric somatostatin." American Journal of Physiology-Gastrointestinal and Liver Physiology 257, no. 2 (1989): G235—G241. http://dx.doi.org/10.1152/ajpgi.1989.257.2.g235.

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Somatostatin is known to have inhibitory effects on the release and action of a wide variety of gut peptides. Previous studies in vivo have suggested a potential inhibitory role for somatostatin even on its own secretion. To determine whether this autoregulatory effect is the result of a direct action of the peptide on the cell that is responsible for its secretion, we examined the effect of a non-immunoreactive but biologically active analogue of somatostatin ([Leu8-D-Trp22-Tyr25]S28) on release of somatostatin-like immunoreactivity (SLI) from isolated canine fundic D-cells. We identified som

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Järemo, Petter, Alenka Jejcic, Vesna Jelic, et al. "Erythrocyte Amyloid Beta Peptide Isoform Distributions in Alzheimer and Mild Cognitive Impairment." Current Alzheimer Research 16, no. 11 (2019): 1050–54. http://dx.doi.org/10.2174/1567205016666191010104355.

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Introduction: We recently showed that Amyloid Beta (Aβ)40 accumulates in erythrocytes and possibly causes cell damage as evidenced by an increased number of assumed injured low-density (kg/L) erythrocytes. Furthermore, we have suggested a separation technique to isolate and concentrate such damaged red blood cells for subsequent analysis. Objectives: We isolated high- and low-density erythrocytes and investigated the accumulation patterns of the Aβ peptides (Aβ40, Aβ42, and Aβ43) in Alzheimer (AD), mild cognitive impairment (MCI), and Subjective Cognitive Impairment (SCI). Methods: Whole blood

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Griffin, John H., and Laurent O. Mosnier. "Activated Protein C Cellular Pathways Regulating Thrombosis." Blood 118, no. 21 (2011): SCI—44—SCI—44. http://dx.doi.org/10.1182/blood.v118.21.sci-44.sci-44.

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Abstract SCI-44 Plasma protein C is known for its mild deficiency linked to venous thrombosis risk and severe deficiency linked to neonatal purpura fulminans. Activated protein C (APC) exerts both anticoagulant activity via proteolytic inactivation of factors Va and VIIIa and cellular cytoprotective actions via direct initiation of cell signaling. Based on studies of engineered APC mutants and the use of genetically modified mice, APC’s cell signaling actions are thought to drive murine APC’s mortality reduction in sepsis models, neuroprotective actions in brain injury models, and nephroprotec

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TORRES, Allan M., Greg M. DE PLATER, Magnus DOVERSKOG, et al. "Defensin-like peptide-2 from platypus venom: member of a class of peptides with a distinct structural fold." Biochemical Journal 348, no. 3 (2000): 649–56. http://dx.doi.org/10.1042/bj3480649.

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The venom of the male Australian duck-billed platypus contains a family of four polypeptides of appox. 5 kDa, which are referred to as defensin-like peptides (DLPs). They are unique in that their amino acid sequences have no significant similarities to those of any known peptides; however, the tertiary structure of one of them, DLP-1, has recently been shown to be similar to β-defensin-12 and to the sodium neurotoxin peptide ShI (Stichodactyla helianthus neurotoxin I). Although DLPs are the major peptides in the platypus venom, little is known about their biological roles. In this study, we de

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Greiner, Jochen, Yoko Ono, Susanne Hofmann, et al. "The Mutated Region of Cytoplasmatic Nucleophosmine 1 (NPM1) Elicits Both CD4+ and CD8+ T Cell Responses." Blood 118, no. 21 (2011): 2569. http://dx.doi.org/10.1182/blood.v118.21.2569.2569.

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Abstract Abstract 2569 Introduction In AML, mutations in the nucleophosmin (NPM1) gene are one of the most frequent molecular alterations and predominantly occur in AML with normal cytogenetics. Patients with NPM1 mutation without FLT3-ITD mutation show a favourable prognosis of their disease. The functional role of mutated NPM1 for the improved clinical outcome is under evaluation. Immune responses might be involved in the clinical outcome of the disease. In this work, we demonstrate both CD4+ and CD8+ T cell responses against the mutated region of NPM1. Methods The entire amino acid sequence

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Cohn, M. "TCR-pMHC interactions: Two peptide repertoires-one signal." Scandinavian Journal of Immunology 88, no. 4 (2018): e12700. http://dx.doi.org/10.1111/sji.12700.

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Rajabinejad, Hossein, Marina Zoccola, Alessia Patrucco, Alessio Montarsolo, Giorgio Rovero, and Claudio Tonin. "Physicochemical properties of keratin extracted from wool by various methods." Textile Research Journal 88, no. 21 (2017): 2415–24. http://dx.doi.org/10.1177/0040517517723028.

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Keratin from wool fibers was extracted with different extraction methods, for example oxidation, reduction, sulfitolysis, and superheated water hydrolysis. Different samples of extracted keratin were characterized by molecular weight determination, FT-IR and NIR spectroscopy, amino acid analysis, and thermal behavior. While using oxidation, reduction, and sulfitolysis, only the cleavage of disulfide bonds takes place; keratin hydrolysis leads to the breaking of peptide bonds with the formation of low molecular weight proteins and peptides. In the FT-IR spectra of keratoses, the formation of cy

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Holler, Ernst, Peter Oefner, Karin Landfried, et al. "Intestinal Microbiota: From Inflammatory Bowel Disease to Bone Marrow Transplantation." Blood 120, no. 21 (2012): SCI—50—SCI—50. http://dx.doi.org/10.1182/blood.v120.21.sci-50.sci-50.

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Abstract Abstract SCI-50 A dysregulated interaction of the intestinal microbiome with the patient's innate and adaptive immune response seems to contribute to both inflammatory bowel disease (IBD) and intestinal graft-versus-host disease (GVHD). In IBD, polymorphisms within genes involved in antibacterial defense have been identified as genetic risk factors, such as in NOD2, a gene coding for an intracytoplasmatic receptor for muramyldipeptide, a bacterial cell wall compound, or in ATG16L1, a gene involved in autophagy of bacteria. Disruption of these genes results in dysfunction of Paneth cel

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Myronovskij, S., N. Negrych, T. Negrych, et al. "Isolation and characterization of peptides from blood serum of patients with multiple sclerosis." Studia Biologica 9, no. 2 (2015): 51–58. http://dx.doi.org/10.30970/sbi.0902.426.

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Williams, Lisa M., Zongming Fu, Pratima Dulloor, et al. "Identification of Thrombospondin-1 and L-Selectin as Potential Plasma Biomarkers of Silent Cerebral Infarct In Children with Sickle Cell Disease Using a Proteomic-Based Approach." Blood 116, no. 21 (2010): 259. http://dx.doi.org/10.1182/blood.v116.21.259.259.

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Abstract Abstract 259 Objectives: Silent cerebral infarction (SCI) occurs in approximately 27% of children with sickle cell disease (SCD) by age 6 years, and is associated with decreased neurocognitive function and a 14-fold increased risk of progression to overt stroke. While several clinical parameters, such as increased white blood cell (WBC) and platelet counts and decreased hemoglobin (Hb) or hematocrit, have been reported in the literature to be associated with SCI, to date no validated biomarkers exist to predict SCI in patients with SCD. Furthermore, recent unpublished data from the Si

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Kalhor-Monfared, S., M. R. Jafari, J. T. Patterson, et al. "Correction: Rapid biocompatible macrocyclization of peptides with decafluoro-diphenylsulfone." Chemical Science 8, no. 1 (2017): 807. http://dx.doi.org/10.1039/c6sc90071b.

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D'Souza, Areetha, Mukesh Mahajan та Surajit Bhattacharjya. "Correction: Designed multi-stranded heme binding β-sheet peptides in membrane". Chemical Science 8, № 1 (2017): 808. http://dx.doi.org/10.1039/c6sc90078j.

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Tatman, Philip D., Ethan G. Muhonen, Sean T. Wickers, Albert O. Gee, Eung-Sam Kim, and Deok-Ho Kim. "Correction: Self-assembling peptides for stem cell and tissue engineering." Biomaterials Science 4, no. 4 (2016): 724. http://dx.doi.org/10.1039/c6bm90013e.

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Ansong, Charles, Stephen Miles, and Philip J. Fay. "Factor VIII A2 Domain Residues 497–510 and 584–593 Comprise the R8B12 Epitope." Blood 106, no. 11 (2005): 4028. http://dx.doi.org/10.1182/blood.v106.11.4028.4028.

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Abstract The murine monoclonal antibody R8B12 recognizes the C-terminal region (residues 563–740) of the A2 subunit of factor VIIIa (Fay et al. J. Biol. Chem. 266:20139, 1991), as judged by western blotting. The location of the R8B12 epitope within the A2 subunit is not known. In the present study we used affinity-directed mass spectrometry (Zhao et al. Proc. Natl. Acad. Sci. USA.93:4020, 1996) to map the R8B12 epitope. Purified A2 subunit was subjected to proteolytic digestion with trypsin. The digest was then subjected to immunoprecipitation (IP) using R8B12 IgG, in which peptide(s) are sele

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Song, Qun, Wen-jie Zhao, He-xing Yin, and Hong-zhen Lian. "Facile synthesis of FeIII–tannic acid film-functionalized magnetic silica microspheres for the enrichment of low-abundance peptides and proteins for MALDI-TOF MS analysis." RSC Advances 5, no. 78 (2015): 63896–902. http://dx.doi.org/10.1039/c5ra05872d.

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