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Journal articles on the topic 'Peptides – Effets du fer'

Author: Grafiati

Published: 3 September 2022

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1

Arregui, Carlos, Purnima Pathre, Jack Lilien та Janne Balsamo. "The Nonreceptor Tyrosine Kinase Fer Mediates Cross-Talk between N-Cadherin and β1-Integrins". Journal of Cell Biology 149, № 6 (2000): 1263–74. http://dx.doi.org/10.1083/jcb.149.6.1263.

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Cadherins and integrins must function in a coordinated manner to effectively mediate the cellular interactions essential for development. We hypothesized that exchange of proteins associated with their cytoplasmic domains may play a role in coordinating function. To test this idea, we used Trojan peptides to introduce into cells and tissues peptide sequences designed to compete for the interaction of specific effectors with the cytoplasmic domain of N-cadherin, and assayed their effect on cadherin- and integrin-mediated adhesion and neurite outgrowth. We show that a peptide mimicking the juxta

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2

Ribeill, Georges. "Gestion et organisation du travail dans les compagnies de chemins de fer, des origines a 1860." Annales. Histoire, Sciences Sociales 42, no. 5 (1987): 999–1029. http://dx.doi.org/10.3406/ahess.1987.283434.

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L'importance de l'avènement des chemins de fer dans l'économie française est bien connue : son rôle décisif pour promouvoir ou susciter de multiples innovations depuis les questions de mobilisation financière jusqu'à celles de la politique de l'Etat en matière de service public, depuis ses effets sur les industries amont (du rail au combustible) ou les marchés aval des productions agricoles et industrielles, jusqu'à des effets structurants de géographie humaine, ont été plus ou moins fouillés. En particulier, depuis longtemps, de nombreux travaux ont été consacrés aux débats et tournants succe

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3

Ahrén, Bo. "Regulatory peptides in the thyroid gland — a review on their localization and function." Acta Endocrinologica 124, no. 3 (1991): 225–32. http://dx.doi.org/10.1530/acta.0.1240225.

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Abstract. It has been demonstrated that nerve fibres storing immunoreactivity of vasoactive intestinal polypeptide, peptide histidine iso-leucine, neuropeptide Y, substance P, calcitonin gene-related peptide, galanin, and cholecystokinin exists in the thyroid, though the content of these neuropeptides is lower in the thyroid than in other organs, like in the gut. Furthermore, the parafollicular C-cells have been shown to harbour several different peptides: calcitonin, somatostatin, calcitonin gene-related peptide, gastrin-releasing peptide, katacalcin and helodermin. In addition, other regulat

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Casciaro, Bruno, Floriana Cappiello, Maria Rosa Loffredo, Francesca Ghirga, and Maria Luisa Mangoni. "The Potential of Frog Skin Peptides for Anti-Infective Therapies: The Case of Esculentin-1a(1-21)NH2." Current Medicinal Chemistry 27, no. 9 (2020): 1405–19. http://dx.doi.org/10.2174/0929867326666190722095408.

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Antimicrobial Peptides (AMPs) are the key effectors of the innate immunity and represent promising molecules for the development of new antibacterial drugs. However, to achieve this goal, some problems need to be overcome: (i) the cytotoxic effects at high concentrations; (ii) the poor biostability and (iii) the difficulty in reaching the target site. Frog skin is one of the richest natural storehouses of AMPs, and over the years, many peptides have been isolated from it, characterized and classified into several families encompassing temporins, brevinins, nigrocins and esculentins. In this re

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Zhao, Chunzhao, Omar Zayed, Zheping Yu, et al. "Leucine-rich repeat extensin proteins regulate plant salt tolerance in Arabidopsis." Proceedings of the National Academy of Sciences 115, no. 51 (2018): 13123–28. http://dx.doi.org/10.1073/pnas.1816991115.

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The perception and relay of cell-wall signals are critical for plants to regulate growth and stress responses, but the underlying mechanisms are poorly understood. We found that the cell-wall leucine-rich repeat extensins (LRX) 3/4/5 are critical for plant salt tolerance in Arabidopsis. The LRXs physically associate with the RAPID ALKALINIZATION FACTOR (RALF) peptides RALF22/23, which in turn interact with the plasma membrane-localized receptor-like protein kinase FERONIA (FER). The lrx345 triple mutant as well as fer mutant plants display retarded growth and salt hypersensitivity, which are m

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Mendez, Rufa, and Jung Kwon. "Pacific Dulse Protein: A Promising Source of Bioactive Peptides." Current Developments in Nutrition 5, Supplement_2 (2021): 597. http://dx.doi.org/10.1093/cdn/nzab044_028.

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Abstract Objectives Pacific dulse (Devaleraea mollis) is a protein-rich seaweed in the Pacific Northwest and increasingly being cultivated as food resource. Our previous work showed that dietary supplementation of dulse exerted beneficial metabolic effects to the high-fat fed mouse model. This study aims to evaluate the potential of the seaweed protein from dulse as a precursor for bioactive peptide (BAP) generation. Methods The potential of Pacific dulse protein as BAP precursor was assessed using in vitro and in silico approaches. Hydrolysates were prepared from the hydrated freeze-dried pro

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Fairlie, David P., Giovanni Abbenante, and Darren R. March. "Macrocyclic Peptidomimetics Forcing Peptides into Bioactive Conformations." Current Medicinal Chemistry 2, no. 2 (1995): 654–86. http://dx.doi.org/10.2174/0929867302666220218001506.

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Abstract: Cyclic peptides that are potent regulators of biological processes are rapidly emerging as important mechanistic probes and drug leads. Nature clearly uses macrocycles to. constrain peptides into conformations that can selectively bind proteins or. small molecules. Therapeutic effects of such macrocycles, often containing additional conformational constraints that fine tune structure (e.g. D-amino acids, N-methyl substituents, aromatic rings, to name a few), have so far been mainly discovered by accident. However it is now becoming possible to rationally design synthetic macrocycles

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8

Zheng, Zihao, Aisha M. Mergaert, Irene M. Ong, Miriam A. Shelef, and Michael A. Newton. "MixTwice: large-scale hypothesis testing for peptide arrays by variance mixing." Bioinformatics 37, no. 17 (2021): 2637–43. http://dx.doi.org/10.1093/bioinformatics/btab162.

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Abstract Summary Peptide microarrays have emerged as a powerful technology in immunoproteomics as they provide a tool to measure the abundance of different antibodies in patient serum samples. The high dimensionality and small sample size of many experiments challenge conventional statistical approaches, including those aiming to control the false discovery rate (FDR). Motivated by limitations in reproducibility and power of current methods, we advance an empirical Bayesian tool that computes local FDR statistics and local false sign rate statistics when provided with data on estimated effects

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9

Yang, Xiao-Yue, Di-Ying Zhong, Guo-Liang Wang, Run-Guang Zhang, and You-Lin Zhang. "Effect of Walnut Meal Peptides on Hyperlipidemia and Hepatic Lipid Metabolism in Rats Fed a High-Fat Diet." Nutrients 13, no. 5 (2021): 1410. http://dx.doi.org/10.3390/nu13051410.

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As a natural active substance that can effectively improve blood lipid balance in the body, hypolipidemic active peptides have attracted the attention of scholars. In this study, the effect of walnut meal peptides (WMP) on lipid metabolism was investigated in rats fed a high-fat diet (HFD). The experimental results show that feeding walnut meal peptides counteracted the high-fat diet-induced increase in body, liver and epididymal fat weight, and reduce the serum concentrations of total cholesterol, triglycerides, and LDL-cholesterol and hepatic cholesterol and triglyceride content. Walnut meal

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10

Moosavi, A. R. Heravi, and M. Danesh Mesgaran. "Ruminal peptide-N concentrations in Iranian Balochi lambs fed diets containing lucerne hay or silage." Proceedings of the British Society of Animal Science 2001 (2001): 145. http://dx.doi.org/10.1017/s1752756200005275.

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Peptides are intermediates in the conversion of ingested protein to ammonia in the rumen and their accumulation depends upon the nature of diet (Mesgaran & Parker, 1995). Transient accumulation of peptides occurs after feeding and then their concentrations declines. In addition, it suggests that the production of peptides in the rumen was not altered by the protein supplements when diets provided similar effective rumen degradable protein (ERDP)(Mesgaran & Moosavi, 1999). The objective of the present experiment was to investigate the effect of diets, with similar ERDP, containing lucer

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Vojtek, B., J. Mojzisova, L. Kulichova, P. Smrco, and M. Drazovska. "Effects of dietary nucleotides and cationic peptides on vaccination response in cats." Veterinární Medicína 66, No. 1 (2021): 17–23. http://dx.doi.org/10.17221/35/2020-vetmed.

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Modulation of the immune system through nutrition is the aim of many studies. As the induction of a rapid onset of immunity in cats is often critical, the objective of this study was to evaluate the effects of orally administered dietary nucleotides and cationic peptides, on the vaccination response in cats. The cats were allocated to two groups: Group A (n = 8) was fed a diet with dietary nucleotides and cationic peptides for ninety-two days, and Group C (n = 8) was fed a diet without the nucleotides and cationic peptides. The cats were vaccinated against feline herpesvirus 1 (FHV-1), feline

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Liang, Ningjian, Robert L. Beverly, Brian P. Scottoline, and David C. Dallas. "Peptides Derived from In Vitro and In Vivo Digestion of Human Milk Are Immunomodulatory in THP-1 Human Macrophages." Journal of Nutrition 152, no. 1 (2021): 331–42. http://dx.doi.org/10.1093/jn/nxab350.

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ABSTRACT Background Milk proteins contain many encrypted bioactive peptides. Whether these bioactive peptides are released in the infant intestine and exert immunomodulatory activity remains unknown. Objective This study examined in vitro immunomodulatory activities of peptides from in vitro– and in vivo–digested human milk. Methods Peptides were extracted from in vitro–digested human milk and pooled intestinal samples from 8 infants fed human milk. Peptides extracted from in vitro–digested samples were fractionated. The in vitro effects of these peptides and fractions on the secretion of TNF-

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Moosavi, A. R. Heravi, and M. Danesh Mesgaran. "Ruminal peptide and soluble protein N concentrations in Iranian Baloochi lambs fed diets containing lucerne hay or silage." Proceedings of the British Society of Animal Science 2002 (2002): 146. http://dx.doi.org/10.1017/s1752756200008024.

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It is generally agreed that peptides accumulate in the rumen fluid after feeding. It has been also suggested that the production of peptides in the rumen was not altered by the protein supplements when diets provided similar effective rumen degradable protein (Mesgaran & Moosavi, 1999). The objective of the present experiment was to investigate the effect of diets containing lucerne hay or silage treated by urea and formaldehyde on the ruminal peptide and soluble protein N concentrations in Iranian Baloochi lambs.

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Kellner, Michael, Ines Diehl, Kristina Knaudt, Cornelius Schüle, Holger Jahn, and Klaus Wiedemann. "C-type natriuretic peptide exerts stimulatory effects on the corticotropin-releasing hormone-induced secretion of hormones in normal man." European Journal of Endocrinology 136, no. 4 (1997): 388–93. http://dx.doi.org/10.1530/eje.0.1360388.

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Abstract C-type natriuretic peptide and atrial natriuretic peptide have been reported to bind to distinct receptors and to exert opposing effects on different systems. Although it is known that atrial natriuretic peptide inhibits the corticotropin-releasing hormone-stimulated hormone release in man, the corresponding action of C-type natriuretic peptide has so far not been characterized. We investigated the effects of 30-min infusions of 150 and 300 μg C-type natriuretic peptide on adrenocorticotropin, cortisol, and prolactin release stimulated by 100 μg corticotropin-releasing hormone and on

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15

Wallace, R. J., C. J. Newbold, and N. McKain. "Influence of ionophores and energy inhibitors on peptide metabolism by rumen bacteria." Journal of Agricultural Science 115, no. 2 (1990): 285–90. http://dx.doi.org/10.1017/s0021859600075250.

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SUMMARYIonophores and inhibitors of bacterial energy metabolism were added to mixed rumen bacteria prepared from sheep receiving grass hay plus concentrate diets, and their influence on the rate of metabolism of alanine (Ala) peptides was determined. Dicyclohexylcarbodiimide (DCCD) had no influence on the rate of breakdown of Ala2, Ala3, Ala4or Ala5, indicating that the metabolism of these peptides did not require ATP. The protonophores tetrachlorosalicylanilide (TCS) and carbonyl cyanidem-chlorophenyl-hydrazone (CCCP) inhibited peptide breakdown to a minor extent (< 15%), whereas the ionop

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Liu, Chen, Lianping Shen, Yu Xiao, et al. "Pollen PCP-B peptides unlock a stigma peptide–receptor kinase gating mechanism for pollination." Science 372, no. 6538 (2021): 171–75. http://dx.doi.org/10.1126/science.abc6107.

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Sexual reproduction in angiosperms relies on precise communications between the pollen and pistil. The molecular mechanisms underlying these communications remain elusive. We established that in Arabidopsis, a stigmatic gatekeeper, the ANJEA–FERONIA (ANJ–FER) receptor kinase complex, perceives the RAPID ALKALINIZATION FACTOR peptides RALF23 and RALF33 to induce reactive oxygen species (ROS) production in the stigma papillae, whereas pollination reduces stigmatic ROS, allowing pollen hydration. Upon pollination, the POLLEN COAT PROTEIN B-class peptides (PCP-Bs) compete with RALF23/33 for bindin

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Danesh Mesgaran, M., and A. R. H. Moosavi. "Effects of diets formulated to contain similar amounts of ERDP with different protein sources on ruminal peptide-N concentrations in Iranian Baloochi lambs." Proceedings of the British Society of Animal Science 1999 (1999): 110. http://dx.doi.org/10.1017/s1752756200002659.

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Peptides are intermediates in the conversion of ingested protein to ammonia in the rumen and their accumulation depends upon the nature of dietary protein (Mesgaran & Parker, 1995). In addition, It has been demonstrated that the hydrolysis rate of peptides was influenced by peptide structure and that proline containing peptides were hydrolysed more slowly by rumen fluid (Mesgaran & Parker, 1996). The objective of the present experiment was to investigate the effect of altering the sources of protein, in diets with similar effective rumen degradable protein (ERDP), on the ruminal peptid

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18

Merger, Michèle. "Les chemins de fer italiens : leur construction et leurs effets amont (1860-1915)." Histoire, économie et société 11, no. 1 (1992): 109–29. http://dx.doi.org/10.3406/hes.1992.1626.

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19

Le Bollan, Christophe. "L’arrivée du chemin de fer à Brest ou les effets d’une logique stratégique." Revue d’histoire des chemins de fer, no. 38 (May 31, 2008): 72–86. http://dx.doi.org/10.4000/rhcf.420.

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20

Lebenthal, Emanuel. "Gastrointestinal Maturation and Motility Patterns as Indicators for Feeding the Premature Infant." Pediatrics 95, no. 2 (1995): 209. http://dx.doi.org/10.1542/peds.95.2.209.

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The Koenig et al study1 showed different effects of two-thirds concentration feeding compared with one-third concentration in relation to shorter mean time of onset and longer duration of fed response. The different motility response can be related to availability of regulatory mechanisms. Similar studies of individual food component,26 eg, glucose, triglyceride, and casein hydrolysate, disrupted fasting activity but had differing effects on the duration of fed activity and the increase of contractile activity. Glucose followed by peptides then lipids caused the greatest increase in contractio

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Yamada, Chihiro. "Involvement of Ghrelin Dynamics in Stress-Induced Eating Disorder: Effects of Sex and Aging." International Journal of Molecular Sciences 22, no. 21 (2021): 11695. http://dx.doi.org/10.3390/ijms222111695.

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Stress, a factor that affects appetite in our daily lives, enhances or suppresses appetite and changes palatability. However, so far, the mechanisms underlying the link between stress and eating have not been fully elucidated. Among the peripherally produced appetite-related peptides, ghrelin is the only orexigenic peptide, and abnormalities in the dynamics and reactivity of this peptide are involved in appetite abnormalities in various diseases and psychological states. This review presents an overview of the research results of studies evaluating the effects of various stresses on appetite.

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Bouzid, Rachid, Monique T. A. de Beijer, Robbie J. Luijten, et al. "Empirical Evaluation of the Use of Computational HLA Binding as an Early Filter to the Mass Spectrometry-Based Epitope Discovery Workflow." Cancers 13, no. 10 (2021): 2307. http://dx.doi.org/10.3390/cancers13102307.

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Immunopeptidomics is used to identify novel epitopes for (therapeutic) vaccination strategies in cancer and infectious disease. Various false discovery rates (FDRs) are applied in the field when converting liquid chromatography-tandem mass spectrometry (LC-MS/MS) spectra to peptides. Subsequently, large efforts have recently been made to rescue peptides of lower confidence. However, it remains unclear what the overall relation is between the FDR threshold and the percentage of obtained HLA-binders. We here directly evaluated the effect of varying FDR thresholds on the resulting immunopeptidome

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Abdelhedi, Ola, Hana Khemakhem, Rim Nasri, et al. "Assessment of Cholesterol, Glycemia Control and Short- and Long-Term Antihypertensive Effects of Smooth Hound Viscera Peptides in High-Salt and Fructose Diet-Fed Wistar Rats." Marine Drugs 17, no. 4 (2019): 194. http://dx.doi.org/10.3390/md17040194.

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In this study, the antihypertensive activity of Purafect®-smooth hound viscera protein hydrolysate (VPH) and its peptide fraction with molecular weight (MW) below 1 kDa (VPH-I) was investigated. In addition, the lipase inhibitory activity, as well the anticoagulant potential, in vitro, were assessed. The antihypertensive effects of VPH and VPH-I were studied during 24 h (short-term effect) and 30 days (long-term effect) using high-salt (18% NaCl) and -fructose (10%) diet (HSFD)-induced hypertension. Data showed that, 4 h post-administration of VPH and VPH-I (200 mg/kg BW), the systolic blood p

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Pantako, Odile T., Lise Lemieux та Jean Amiot. "The effects of α-lactabumin and whey protein concentrate on dry matter recovery, TCA soluble protein levels, and peptide distribution in the rat gastrointestinal tract". Canadian Journal of Physiology and Pharmacology 79, № 4 (2001): 320–28. http://dx.doi.org/10.1139/y00-126.

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The effects of two dietary proteins on dry matter recovery, trichloroacetic acid (TCA) soluble protein concentration, and peptide distribution in gastrointestinal contents were investigated in rats trained to consume, in a single 2-hour daily meal, diets containing α-lactalbumin (α-LA) or whey protein concentrate (WPC) for two weeks. Compared with the WPC diet, the α-LA diet emptied faster from the stomach. Dry matter recovery was higher in the stomach contents of rats fed the WPC diet than in those given the α-LA diet, but dry matter content in the small intestine was comparable. TCA soluble

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Santos, André L. S., Filipe P. Matteoli, Leandro S. Sangenito, Marta H. Branquinha, Bruno A. Cotrim, and Gabriel O. Resende. "Asymmetric peptidomimetics containing L-tartaric acid core inhibit the aspartyl peptidase activity and growth of Leishmania amazonensis promastigotes." Acta Parasitologica 63, no. 1 (2018): 114–24. http://dx.doi.org/10.1515/ap-2018-0013.

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AbstractAspartyl-type peptidases are promising chemotherapeutic targets in protozoan parasites. In the present work, we identified an aspartyl peptidase activity from the soluble extract ofLeishmania amazonensispromastigotes, which cleaved the fluorogenic peptide 7-methoxycoumarin-4-acetyl-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(DNP)-D-Arg-amide (cathepsin D substrate) under acidic pH conditions at 37°C, showing aKMof 0.58 μM andVmaxof 129.87 fluorescence arbitrary units/s mg protein. The leishmanial aspartyl peptidase activity was blocked by pepstatin A (IC50= 6.8 μM) and diazo-acetyl-norleuc

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Pasco, Sylvie, Laurent Ramont, François-Xavier Maquart, and Jean-Claude Monboisse. "Effets biologiques de peptides des collagènes I et IV." Journal de la Société de Biologie 197, no. 1 (2003): 31–39. http://dx.doi.org/10.1051/jbio/2003197010031.

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Martin, Christine M. A., Vadivel Parthsarathy, Varun Pathak, Victor A. Gault, Peter R. Flatt, and Nigel Irwin. "Characterisation of the biological activity of xenin-25 degradation fragment peptides." Journal of Endocrinology 221, no. 2 (2014): 193–200. http://dx.doi.org/10.1530/joe-13-0617.

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Xenin-25, a peptide co-secreted with the incretin hormone glucose-dependent insulinotropic polypeptide (GIP), possesses promising therapeutic actions for obesity-diabetes. However, native xenin-25 is rapidly degraded by serum enzymes to yield the truncated metabolites: xenin 9–25, xenin 11–25, xenin 14–25 and xenin 18–25. This study has examined the biological activities of these fragment peptides. In vitro studies using BRIN-BD11 cells demonstrated that native xenin-25 and xenin 18–25 possessed significant (P<0.05 to P<0.001) insulin-releasing actions at 5.6 and 16.7 mM glucose, respect

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Wei, Xiaoyuan, Tsungcheng Tsai, Joshua Knapp, et al. "ZnO Modulates Swine Gut Microbiota and Improves Growth Performance of Nursery Pigs When Combined with Peptide Cocktail." Microorganisms 8, no. 2 (2020): 146. http://dx.doi.org/10.3390/microorganisms8020146.

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Zinc has been very efficacious in reducing post-weaning diarrhea, whereas animal-derived peptides are suggested to improve the growth performance of weaned piglets. However, the combined effect of zinc and peptides on swine production and swine gut microbiota is still largely unknown. In this study, we followed 288 nursery pigs from the age of d30 to d60 to evaluate the growth performance and gut microbiota of weanling pigs subjected to different levels of a fish-porcine-microbial peptide cocktail (0.05%, 0.25%, and 0.5%) with or without the pharmaceutical level of zinc oxide (ZnO) (2500 ppm)

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Yang, Wenzhu, YiZhao Shen, Ranithri Abeynayakea, Tao Ran, and Lingyun Chen. "PSIX-12 Screening of peptides for their impact of protease, protease dose and peptide dose on in vitro rumen dry matter digestibility." Journal of Animal Science 97, Supplement_3 (2019): 398–99. http://dx.doi.org/10.1093/jas/skz258.794.

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Abstract The objective of this study was to screening peptides for the effects on in vitro rumen dry matter (DM) digestibility (DMD) of feeds in batch culture. Three brewers spent grain (BSG) samples from different batches were obtained from a local brewery. Peptides were developed with BSG protein varying protease (alcalase, everlase, flavourzyme) and protease dosages (protease:BSG protein; 1:100, 5:100, 10:100, 15:100) under optimum pH and temperature conditions. In total, 36 peptides were produced and screened. A series of batch cultures were conducted and substrates were barley silage and

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Lu, Hongyan, Li Fang, Xiyan Wang, et al. "Structure-Activity Relationship of Pine Nut-Derived Peptides and Their Protective Effect on Nerve-Cell Mitochondria." Foods 11, no. 10 (2022): 1428. http://dx.doi.org/10.3390/foods11101428.

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This study aimed to investigate the structure-activity relationship of the pine nut antioxidant peptide WYPGK and its derivative peptides, and to evaluate the protective effect of the latter on oxidative damage to mitochondrial structure and function in PC12 cells. Molecular docking revealed the derivative peptides WYFGK and WYSGK to have higher affinity to the active region of sirtuin 3 (SIRT3) (−6.08 kcal/mol and −5.87 kcal/mol, respectively), hence indicating that they are promising SIRT3 inducers and antioxidant factors. The derivative peptide WYSGK presented the highest ORAC value (5457.7

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Reid, Scott W., Steve McAdam, Kathrine J. Smith, et al. "Antagonist HIV-1 Gag Peptides Induce Structural Changes in HLA B8." Journal of Experimental Medicine 184, no. 6 (1996): 2279–86. http://dx.doi.org/10.1084/jem.184.6.2279.

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In the cellular immune response, recognition by CTL-TCRs of viral antigens presented as peptides by HLA class I molecules, triggers destruction of the virally infected cell (Townsend, A.R.M., J. Rothbard, F.M. Gotch, G. Bahadur, D. Wraith, and A.J. McMichael. 1986. Cell. 44:959–968). Altered peptide ligands (APLs) which antagonise CTL recognition of infected cells have been reported (Jameson, S.C., F.R. Carbone, and M.J. Bevan. 1993. J. Exp. Med. 177:1541–1550). In one example, lysis of antigen presenting cells by CTLs in response to recognition of an HLA B8–restricted HIV-1 P17 (aa 24–31) epi

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Zabielski, Romuald, Claude Dardillat, Isabelle Le Huërou-Luron, Christine Bernard, Jean Alain Chayvialle, and Paul Guilloteau. "Periodic fluctuations of gut regulatory peptides in phase with the duodenal migrating myoelectric complex in preruminant calves: effect of different sources of dietary protein." British Journal of Nutrition 79, no. 3 (1998): 287–96. http://dx.doi.org/10.1079/bjn19980046.

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Four preruminant calves with implanted electrodes in the duodenum and a catheter in the external jugular vein were used for investigation of plasma gut regulatory peptide profiles during different phases of migrating myoelectric complex (MMC) in the small intestine. The effects of different dietary proteins on the rhythmic activity of gut peptides and gastrointestinal motility were compared. In particular, the effects of skimmed-milk protein (retaining physiological patterns of abomasal clotting, and abomaso-intestinal digesta flow)v.fish protein (devoid of clotting activity and modifying the

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Shi, Wanxia, Pengchen He, Xian-Chun Zeng, Weiwei Wu, and Xiaoming Chen. "Inhibitory Effect of an Acidic Peptide on the Activity of an Antimicrobial Peptide from the Scorpion Mesobuthus martensii Karsch." Molecules 23, no. 12 (2018): 3314. http://dx.doi.org/10.3390/molecules23123314.

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Highly acidic peptides with no disulfide bridges are widely present in the scorpion venoms; however, none of them has been functionally characterized so far. Here, we cloned the full-length cDNA of a short-chain highly acidic peptide (referred to as HAP-1) from a cDNA library made from the venom glands of the Chinese scorpion Mesobuthus martensii Karsch. HAP-1 contains 19 amino acid residues with a predicted IP value of 4.25. Acidic amino residues account for 33.3% of the total residues in the molecule of HAP-1. HAP-1 shows 76–98% identities to some scorpion venom peptides that have not yet be

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Gil-Lozano, Manuel, Diego Pérez-Tilve, Mayte Alvarez-Crespo, et al. "GLP-1(7-36)-amide and Exendin-4 Stimulate the HPA Axis in Rodents and Humans." Endocrinology 151, no. 6 (2010): 2629–40. http://dx.doi.org/10.1210/en.2009-0915.

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Glucagon-like peptide-1 (GLP-1) is a potent insulinotropic peptide expressed in the gut and brain, which is secreted in response to food intake. The levels of GLP-1 within the brain have been related to the activity of the hypothalamic-pituitary-adrenal (HPA) axis, and hence, this peptide might mediate some responses to stress. Nevertheless, there is little information regarding the effects of circulating GLP-1 on the neuroendocrine control of HPA activity. Here, we have studied the response of corticoadrenal steroids to the peripheral administration of GLP-1 (7-36)-amide and related peptides

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Lupi, Laura, Brenda Bracco, Paola Sassi, et al. "Hydration Dynamics of Model Peptides with Different Hydrophobic Character." Life 12, no. 4 (2022): 572. http://dx.doi.org/10.3390/life12040572.

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The multi-scale dynamics of aqueous solutions of the hydrophilic peptide N-acetyl-glycine-methylamide (NAGMA) have been investigated through extended frequency-range depolarized light scattering (EDLS), which enables the broad-band detection of collective polarizability anisotropy fluctuations. The results have been compared to those obtained for N-acetyl-leucinemethylamide (NALMA), an amphiphilic peptide which shares with NAGMA the same polar backbone, but also contains an apolar group. Our study indicates that the two model peptides induce similar effects on the fast translational dynamics o

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Finn, Patricia D., David Rodriguez, Jill Kohler, et al. "Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice." American Journal of Physiology-Gastrointestinal and Liver Physiology 316, no. 3 (2019): G412—G424. http://dx.doi.org/10.1152/ajpgi.00300.2018.

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Takeda G protein-coupled receptor 5 (TGR5) agonists induce systemic release of glucagon-like peptides (GLPs) from intestinal L cells, a potentially therapeutic action against metabolic diseases such as nonalcoholic steatohepatitis (NASH), nonalcoholic fatty liver disease (NAFLD), and Type 2 diabetes. Historically, TGR5 agonist use has been hindered by side effects, including inhibition of gallbladder emptying. Here, we characterize RDX8940, a novel, orally administered TGR5 agonist designed to have minimal systemic effects and investigate its activity in mice fed a Western diet, a model of NAF

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Kogut, Michael H., Kenneth J. Genovese, Haiqi He, Christina L. Swaggerty, and Yiwei Jiang. "Modulation of Chicken Intestinal Immune Gene Expression by Small Cationic Peptides as Feed Additives during the First Week Posthatch." Clinical and Vaccine Immunology 20, no. 9 (2013): 1440–48. http://dx.doi.org/10.1128/cvi.00322-13.

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ABSTRACTWe have been investigating modulation strategies tailored around the selective stimulation of the host's immune system as an alternative to direct targeting of microbial pathogens by antibiotics. One such approach is the use of a group of small cationic peptides (BT) produced by a Gram-positive soil bacterium,Brevibacillus texasporus. These peptides have immune modulatory properties that enhance both leukocyte functional efficiency and leukocyte proinflammatory cytokine and chemokine mRNA transcription activitiesin vitro. In addition, when provided as a feed additive for just 4 days po

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Berkovich, A., M. C. O'Keefe, P. Hensley, and L. Caporale. "Effect of N-methylation on the modulation by synthetic peptides of the activity of the complement-factor-B-derived serine proteinase CVFBb." Biochemical Journal 270, no. 2 (1990): 531–37. http://dx.doi.org/10.1042/bj2700531.

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Although they share the active-site catalytic triad of less-specific enzymes such as trypsin and chymotrypsin, the serine proteinases of the complement and coagulation cascades each cleave a highly restricted set of substrates. Peptides with sequences similar to that at which C3 is cleaved by the alternative-pathway complement proteinase CVFBb were synthesized by solid-phase methodology and examined for their effects on the activity of this enzyme as measured by three different types of assays. It was found that a peptide methylated at the scissile bond was a far more effective inhibitor of th

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Rehfeld, Jens F. "Premises for Cholecystokinin and Gastrin Peptides in Diabetes Therapy." Clinical Medicine Insights: Endocrinology and Diabetes 12 (January 2019): 117955141988360. http://dx.doi.org/10.1177/1179551419883608.

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Gastrin and cholecystokinin (CCK) are classical gastrointestinal peptide hormones. Their biogenesis, structures, and intestinal secretory patterns are well-known with the striking feature that their receptor-bound ‘active sites’ are highly homologous and that this structure is conserved for more than 500 million years during evolution. Consequently, gastrin and CCK are agonists for the same receptor (the CCK2 receptor). But in addition, tyrosyl O-sulphated CCK are also bound to the specific CCK1 receptor. The receptors are widely expressed in the body, including pancreatic islet-cell membranes

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Kovačević, Monika, Mojca Čakić Semenčić, Kristina Radošević, et al. "Conformational Preferences and Antiproliferative Activity of Peptidomimetics Containing Methyl 1′-Aminoferrocene-1-carboxylate and Turn-Forming Homo- and Heterochiral Pro-Ala Motifs." International Journal of Molecular Sciences 22, no. 24 (2021): 13532. http://dx.doi.org/10.3390/ijms222413532.

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The concept of peptidomimetics is based on structural modifications of natural peptides that aim not only to mimic their 3D shape and biological function, but also to reduce their limitations. The peptidomimetic approach is used in medicinal chemistry to develop drug-like compounds that are more active and selective than natural peptides and have fewer side effects. One of the synthetic strategies for obtaining peptidomimetics involves mimicking peptide α-helices, β-sheets or turns. Turns are usually located on the protein surface where they interact with various receptors and are therefore in

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Vakili, Alireza, Mohsen Danesh Mesgaran, Reza Valizadeh, Alireza Heravi Moussavi, Mohammad Reza Nassiry, and Ali Hosseinkhani. "Ruminal peptide and ammonia nitrogen concentrations in steers fed diets with different concentrate to lucerne hay ratios." Proceedings of the British Society of Animal Science 2007 (April 2007): 214. http://dx.doi.org/10.1017/s1752756200021177.

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In ruminants, as much as 50% of the dietary crude protein can be converted to ammonia by ruminal microorganisms. A part of ammonia can be utilized as a bacterial nitrogen source; however, rates of ammonia production often exceed rates of ammonia utilization. Peptides are intermediates in the conversion of ingested protein to ammonia in the rumen and their accumulation depends upon the nature of diet (Mesgaran & Parker, 1995). The objective of the present experiment was to investigate the effect of diets differing in concentrate: lucerne hay ratios on the ruminal pH, ammonia-nitrogen concen

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Sonklin, Chanikan, Natta Laohakunjit, and Orapin Kerdchoechuen. "Assessment of antioxidant properties of membrane ultrafiltration peptides from mungbean meal protein hydrolysates." PeerJ 6 (July 27, 2018): e5337. http://dx.doi.org/10.7717/peerj.5337.

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Background Bioactive peptides can prevent damage associated with oxidative stress in humans when consumed regularly. Recently, peptides have attracted immense interest because of their beneficial functional properties, safety and little or no side effects when used at high concentration. Most antioxidant peptides are small in size, less than 1 kDa, and contains a high proportion of hydrophobic amino acid. Particularly, tyrosine, leucine, alanine, isoleucine, valine, lysine, phenyalanine, cysteine, methionine and histidine in peptide chain exhibited high antioxidant activity. Mungbean meal prot

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Panigrahi, Sunil K., Kana Meece, and Sharon L. Wardlaw. "Effects of Naltrexone on Energy Balance and Hypothalamic Melanocortin Peptides in Male Mice Fed a High-Fat Diet." Journal of the Endocrine Society 3, no. 3 (2019): 590–601. http://dx.doi.org/10.1210/js.2018-00379.

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Abstract The hypothalamic melanocortin system composed of proopiomelanocortin (POMC) and agouti-related protein (AgRP) neurons plays a key role in maintaining energy homeostasis. The POMC-derived peptides, α-MSH and β-EP, have distinct roles in this process. α-MSH inhibits food intake, whereas β-EP, an endogenous opioid, can inhibit POMC neurons and stimulate food intake. A mouse model was used to examine the effects of opioid antagonism with naltrexone (NTX) on Pomc and Agrp gene expression and POMC peptide processing in the hypothalamus in conjunction with changes in energy balance. There we

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Morin, A., B. Charley, A. Petit, and L. Chedid. "Effets protecteurs des muramyl peptides vis-a-vis d'infections virales expérimentales." Médecine et Maladies Infectieuses 15, no. 5 (1985): 298. http://dx.doi.org/10.1016/s0399-077x(85)80126-8.

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Tavares, Eva, Rosario Maldonado, and Francisco J. Miñano. "Aminoprocalcitonin-mediated suppression of feeding involves the hypothalamic melanocortin system." American Journal of Physiology-Endocrinology and Metabolism 304, no. 12 (2013): E1251—E1262. http://dx.doi.org/10.1152/ajpendo.00590.2012.

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Aminoprocalcitonin (N-PCT), a neuroendocrine peptide encoded by the calcitonin-I (CALC-I) gene, suppresses food intake when administered centrally in rats. However, the neural pathways underlying this effect remain unclear. N-PCT and calcitonin receptors (CT-R) have been identified in hypothalamic regions involved in energy homeostasis, including the arcuate nucleus (ARC). Here, we hypothesized an involvement of the hypothalamic ARC in mediating the anorexic effects of central N-PCT based on its content of peptidergic neurons involved in feeding and its expression of N-PCT and CT-R. Fasting st

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Eken, Ahmet, Vivian Ortiz, and Jack R. Wands. "Ethanol Inhibits Antigen Presentation by Dendritic Cells." Clinical and Vaccine Immunology 18, no. 7 (2011): 1157–66. http://dx.doi.org/10.1128/cvi.05029-11.

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ABSTRACTPrevious studies suggest that altered virus-specific T-cell responses observed during chronic ethanol exposure may be due to abnormal functioning of dendritic cells (DCs). Here we explored the effects of ethanol on exogenous antigen presentation by DCs. BALB/c, C57BL/6, and CBA/caj mice were fed ethanol or an isocaloric control diet for 8 weeks. The splenic DC population was expanded using an Flt3L expression plasmid via tail vein injection. DCs were purified and assessed for antigen presentation and processing and for peptide-major histocompatibility complex class I and II (MHCI and M

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Mercier, A. J., I. Orchard, and V. TeBrugge. "FMRFamide-like immunoreactivity in the crayfish nervous system." Journal of Experimental Biology 156, no. 1 (1991): 519–38. http://dx.doi.org/10.1242/jeb.156.1.519.

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FMRFamide-like immunoreactivity (FLI) was detected in the nervous system of the crayfish Procambarus clarkii using an antiserum that recognizes extended RFamide peptides. Immunocytochemistry revealed FLI in neuronal somata, axons and varicose processes within the central nervous system. In the periphery, plexuses of immunoreactive varicosities were present in the pericardial organs (POs), in thoracic roots and on the hindgut. The hindgut plexus arose from 3–5 axons leaving the sixth abdominal ganglion (A6) via the intestinal nerve. The presence of FLI in these locations was confirmed by radioi

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Hothi, S. K., D. P. Randall, and M. A. Titheradge. "[Leu]enkephalin stimulates carbohydrate metabolism in isolated hepatocytes and kidney tubule fragments by interaction with angiotensin II receptors." Biochemical Journal 257, no. 3 (1989): 705–10. http://dx.doi.org/10.1042/bj2570705.

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The possibility that the effects of [Leu]enkephalin in vitro on hepatic carbohydrate metabolism are mediated by interaction with angiotensin II receptors has been examined. Preincubation of hepatocytes with either the angiotensin II receptor antagonist [Sar1,Ile8]angiotensin II or 10 mM-dithiothreitol abolished the ability of both angiotensin II and [Leu]enkephalin to increase phosphorylase a in hepatocytes prepared from fed rats. Dithiothreitol had no effect on the stimulation of phosphorylase in the presence of glucagon or phenylephrine, although it also inhibited the response to vasopressin

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Williams, Gareth, Helena M. Cardoso, Ying C. Lee, et al. "Hypothalamic regulatory peptides in obese and lean Zucker rats." Clinical Science 80, no. 5 (1991): 419–26. http://dx.doi.org/10.1042/cs0800419.

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1. Hypothalamic concentrations of nine peptides with experimental effects on energy balance were compared in obese (fa/fa) and lean (Fa/?) male Zucker rats. To determine whether any peptide differences between obese and lean rats might be due to the overweight condition per se, separate groups of obese rats were food-restricted to reduce their body weight to lean values. 2. Concentrations of neuromedin B, a bombesin-like peptide, in the central hypothalamus were significantly higher in obese than in lean rats. This difference was not affected in food-restricted obese rats. 3. Hypothalamic leve

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Rivas-Urbina, Andrea, Anna Rull, Joile Aldana-Ramos, et al. "Subcutaneous Administration of Apolipoprotein J-Derived Mimetic Peptide d-[113–122]apoJ Improves LDL and HDL Function and Prevents Atherosclerosis in LDLR-KO Mice." Biomolecules 10, no. 6 (2020): 829. http://dx.doi.org/10.3390/biom10060829.

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Mimetic peptides are potential therapeutic agents for atherosclerosis. d-[113–122]apolipoprotein (apo) J (d-[113–122]apoJ) is a 10-residue peptide that is predicted to form a class G* amphipathic helix 6 from apoJ; it shows anti-inflammatory and anti-atherogenic properties. In the present study, we analyzed the effect of d-[113–122]apoJ in low-density lipoprotein receptor knockout mice(LDLR-KO) on the development of atherosclerosis and lipoprotein function. Fifteen-week-old female LDLR-KO mice fed an atherogenic Western-type diet were treated for eight weeks with d-[113–122]apoJ peptide, a scr

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