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1

Urban, Jennifer M., Janson Ho, Gavin Piester, Riqiang Fu та Bradley L. Nilsson. "Rippled β-Sheet Formation by an Amyloid-β Fragment Indicates Expanded Scope of Sequence Space for Enantiomeric β-Sheet Peptide Coassembly". Molecules 24, № 10 (2019): 1983. http://dx.doi.org/10.3390/molecules24101983.

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In 1953, Pauling and Corey predicted that enantiomeric β-sheet peptides would coassemble into so-called “rippled” β-sheets, in which the β-sheets would consist of alternating l- and d-peptides. To date, this phenomenon has been investigated primarily with amphipathic peptide sequences composed of alternating hydrophilic and hydrophobic amino acid residues. Here, we show that enantiomers of a fragment of the amyloid-β (Aβ) peptide that does not follow this sequence pattern, amyloid-β (16–22), readily coassembles into rippled β-sheets. Equimolar mixtures of enantiomeric amyloid-β (16–22) peptide
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2

Santamaría, Carlos, Silda Larios, Steve Quirós, et al. "Bactericidal and Antiendotoxic Properties of Short Cationic Peptides Derived from a Snake Venom Lys49 Phospholipase A2." Antimicrobial Agents and Chemotherapy 49, no. 4 (2005): 1340–45. http://dx.doi.org/10.1128/aac.49.4.1340-1345.2005.

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ABSTRACT The activities of short synthetic, nonhemolytic peptides derived from the C-terminal region of myotoxin II, a catalytically inactive phospholipase A2 homologue present in the venom of the snake Bothrops asper, have been shown to reproduce the bactericidal activity of the parent protein. They combine cationic and hydrophobic-aromatic amino acids, thus functionally resembling the antimicrobial peptides of innate defenses. This study evaluated the antimicrobial and antiendotoxic properties of a 13-mer derivative peptide of the C-terminal sequence from positions 115 to 129 of myotoxin II,
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3

Novelli, Federica, Serena De Santis, Stefano Morosetti, Mattia Titubante, Giancarlo Masci, and Anita Scipioni. "Peptides with regularly alternating enantiomeric sequence: From ion channel models to bioinspired nanotechnological applications." Peptide Science 110, no. 5 (2018): e24043. http://dx.doi.org/10.1002/pep2.24043.

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4

Strömstedt, Adam A., Mukesh Pasupuleti, Artur Schmidtchen, and Martin Malmsten. "Evaluation of Strategies for Improving Proteolytic Resistance of Antimicrobial Peptides by Using Variants of EFK17, an Internal Segment of LL-37." Antimicrobial Agents and Chemotherapy 53, no. 2 (2008): 593–602. http://dx.doi.org/10.1128/aac.00477-08.

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ABSTRACT Methods for increasing the proteolytic stability of EFK17 (EFKRIVQRIKDFLRNLV), a new peptide sequence with antimicrobial properties derived from LL-37, were evaluated. EFK17 was modified by four d-enantiomer or tryptophan (W) substitutions at known protease cleavage sites as well as by terminal amidation and acetylation. The peptide variants were studied in terms of proteolytic resistance, antibacterial potency, and cytotoxicity but also in terms their adsorption at model lipid membranes, liposomal leakage generation, and secondary-structure behavior. The W substitutions resulted in a
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5

Agostini, Luigi, and Stefano Morosetti. "In silico Design of Glyco-D,L-Peptide Antiviral Molecules." Journal of Computational Biophysics and Chemistry 21, no. 03 (2022): 349–60. http://dx.doi.org/10.1142/s2737416522500132.

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Background: Most licensed antiviral drugs are nucleoside analogs. A recent research focuses on blocking a virus from entering the cells in the viral cell adsorption/entry stage. In this entry mechanism, the glycans present on the viral surface play a fundamental role. Homochiral L-peptides acting this fusion mechanism have shown some inhibition of viral infection. Peptides with regularly alternating enantiomeric sequence (L,D-peptides) can assume structures that are not accessible to the corresponding homochiral molecules. Furthermore, L,D-peptides are less sensitive to enzymatic digestion. Ai
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6

De Santis, Pasquale, Stefano Morosetti, and Anita Scipioni. "Peptides with Regular Enantiomeric Sequences: A Wide Class of Modular Self-Assembling Architectures." Journal of Nanoscience and Nanotechnology 7, no. 7 (2007): 2230–38. http://dx.doi.org/10.1166/jnn.2007.644.

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7

Cavaco, Marco, Javier Valle, Ruben da Silva, et al. "DPepH3, an Improved Peptide Shuttle for Receptor-independent Transport Across the Blood-Brain Barrier." Current Pharmaceutical Design 26, no. 13 (2020): 1495–506. http://dx.doi.org/10.2174/1381612826666200213094556.

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Background: The use of peptides as drug carriers across the blood-brain barrier (BBB) has increased significantly during the last decades. PepH3, a seven residue sequence (AGILKRW) derived from the α-helical domain of the dengue virus type-2 capsid protein, translocates across the BBB with very low toxicity. Somehow predictably from its size and sequence, PepH3 is degraded in serum relatively fast. Among strategies to increase peptide half-life (t1/2), the use of the enantiomer (wholly made of D-amino acid residues) can be quite successful if the peptide interacts with a target in non-stereosp
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8

Matsuo, Naoki, Natsuko Goda, Takeshi Tenno, and Hidekazu Hiroaki. "Cryoprotective activities of FK20, a human genome-derived intrinsically disordered peptide against cryosensitive enzymes without a stereospecific molecular interaction." PeerJ Physical Chemistry 3 (December 14, 2021): e20. http://dx.doi.org/10.7717/peerj-pchem.20.

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Background Intrinsically disordered proteins (IDPs) have been shown to exhibit cryoprotective activity toward other cellular enzymes without any obvious conserved sequence motifs. This study investigated relationships between the physical properties of several human genome-derived IDPs and their cryoprotective activities. Methods Cryoprotective activity of three human-genome derived IDPs and their truncated peptides toward lactate dehydrogenase (LDH) and glutathione S-transferase (GST) was examined. After the shortest cryoprotective peptide was defined (named FK20), cryoprotective activity of
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9

DÍAZ-ACHIRICA, Pilar, Josep UBACH, Almudena GUINEA, David ANDREU, and Luis RIVAS. "The plasma membrane of Leishmania donovani promastigotes is the main target for CA(1–8)M(1–18), a synthetic cecropin A–melittin hybrid peptide." Biochemical Journal 330, no. 1 (1998): 453–60. http://dx.doi.org/10.1042/bj3300453.

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Reports on the lethal activity of animal antibiotic peptides have largely focused on bacterial rather than eukaryotic targets. In these, involvement of internal organelles as well as mechanisms different from those of prokaryotic cells have been described. CA(1-8)M(1-18) is a synthetic cecropin A-melittin hybrid peptide with leishmanicidal activity. Using Leishmania donovani promastigotes as a model system we have studied the mechanism of action of CA(1-8)M(1-18), its two parental peptides and two analogues. At micromolar concentration CA(1-8)M(1-18) induces a fast permeability to H+/OH-, coll
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10

Czerwenka, Christoph, and Wolfgang Lindner. "Enantiomer discrimination of peptides by tandem mass spectrometry: influence of the peptide sequence on chiral recognition." Rapid Communications in Mass Spectrometry 18, no. 22 (2004): 2713–18. http://dx.doi.org/10.1002/rcm.1671.

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11

Andreeff, Michael, Marina Konopleva, Julie C. Watt, et al. "A Novel Peptide Containing a Nine Amino Acid Sequence from Nur77 Induces Bcl-2-Dependent Apoptosis in AML." Blood 108, no. 11 (2006): 2607. http://dx.doi.org/10.1182/blood.v108.11.2607.2607.

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Abstract Nur77 (also known as TR3 and NGFI-B) is a nuclear orphan receptor that in response to various stimuli can translocate from the nucleus to the mitochondria, bind Bcl-2, and induce a conformational change in Bcl-2 that exposes its BH3 domain. This conformational change of Bcl-2 transforms this protein into a pro-apoptotic molecule that can induce cytochrome c release and apoptosis (Cell 116:527, 2004). Interestingly, in acute myeloid leukemia (AML) cell lines and blasts, Nur77 is absent. We have recently generated a nine amino acid peptide from the Nur77 protein (TR3) that is capable of
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12

Alvarez-Bravo, J., S. Kurata, and S. Natori. "Novel synthetic antimicrobial peptides effective against methicillin-resistant Staphylococcus aureus." Biochemical Journal 302, no. 2 (1994): 535–38. http://dx.doi.org/10.1042/bj3020535.

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Previously, we identified a core undecapeptide of sapecin B having antimicrobial activity. Based on the structure of this peptide, we systematically synthesized peptides consisting of terminal basic motifs and internal oligo-leucine sequences and examined their antimicrobial activities. Of these peptides, RLKLLLLLRLK-NH2 and KLKLLLLLKLK-NH2 were found to have potent microbicidal activity against Staphylococcus aureus, Escherichia coli, methicillin-resistant S. aureus and Candida albicans in liquid medium. We also synthesized the D-enantiomer of KLKLLLLLKLK-NH2. This enantiomer was resistant to
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13

CLOOS, Paul A. C., and Christian FLEDELIUS. "Collagen fragments in urine derived from bone resorption are highly racemized and isomerized: a biological clock of protein aging with clinical potential." Biochemical Journal 345, no. 3 (2000): 473–80. http://dx.doi.org/10.1042/bj3450473.

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Fragments of the α1 C-terminal telopeptide of type I collagen containing the sequence AHDGGR1209-1214 (CTx) can be measured in urine as an index of bone resorption. We report here that these molecules undergo racemization and isomerization of Asp1211in vitro and in vivo, generating a mixture of four isomers: the native peptide form (αL), an isomerized form containing a β-Asp bond (βL), a racemized form containing a D-Asp residue (αD) and an isomerized/racemized form (βD). To study these reactions at this specific site in collagen, we have employed four immunoassays, each specific for one of th
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14

Minkiewicz, Iwaniak, and Darewicz. "BIOPEP-UWM Database of Bioactive Peptides: Current Opportunities." International Journal of Molecular Sciences 20, no. 23 (2019): 5978. http://dx.doi.org/10.3390/ijms20235978.

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The BIOPEP-UWM™ database of bioactive peptides (formerly BIOPEP) has recently become a popular tool in the research on bioactive peptides, especially on these derived from foods and being constituents of diets that prevent development of chronic diseases. The database is continuously updated and modified. The addition of new peptides and the introduction of new information about the existing ones (e.g., chemical codes and references to other databases) is in progress. New opportunities include the possibility of annotating peptides containing D-enantiomers of amino acids, batch processing opti
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15

Wakabayashi, Hiroyuki, Hiroshi Matsumoto, Koichi Hashimoto, Susumu Teraguchi, Mitsunori Takase, and Hirotoshi Hayasawa. "N-Acylated and d Enantiomer Derivatives of a Nonamer Core Peptide of Lactoferricin B Showing Improved Antimicrobial Activity." Antimicrobial Agents and Chemotherapy 43, no. 5 (1999): 1267–69. http://dx.doi.org/10.1128/aac.43.5.1267.

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ABSTRACT N-acylated or d enantiomer peptide derivatives based on the sequence RRWQWRMKK in lactoferricin B demonstrated antimicrobial activities greater than those of lactoferricin B against bacteria and fungi. The most potent peptide, conjugated with an 11-carbon-chain acyl group, showed two to eight times lower MIC than lactoferricin B.
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16

Chong, Pele, Charles Sia, Brian Tripet, Olive James, and Michel Klein. "Comparative immunological properties of enantiomeric peptides." Letters in Peptide Science 3, no. 2 (1996): 99–106. http://dx.doi.org/10.1007/bf00126739.

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17

Kukhar, Valery, Vladimir Solodenko, Vadim Soloshonok, and Tamara Kasheva. "Synthesis of Enantiomeric Aminophosphonic Acids and Peptides." Phosphorus, Sulfur, and Silicon and the Related Elements 109, no. 1-4 (1996): 529–32. http://dx.doi.org/10.1080/10426509608545207.

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18

Cavini, Italo A., Claudia E. Munte, Markus Beck Erlach та ін. "Inhibition of amyloid Aβ aggregation by high pressures or specificd-enantiomeric peptides". Chemical Communications 54, № 26 (2018): 3294–97. http://dx.doi.org/10.1039/c8cc01458b.

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19

Pospíšek, Jan, and Karel Bláha. "Peptides containing a neopentylglycine residue." Collection of Czechoslovak Chemical Communications 52, no. 2 (1987): 514–21. http://dx.doi.org/10.1135/cccc19870514.

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Neopentylglycine (III, 2-amino-4,4-dimethylpentanoic acid) was synthesized in both enantiomeric forms. Using the conventional methods of peptide synthesis, L-prolyl-L-neopentylglycylglycine amide (VII), the diastereoisomeric cyclodipeptides cyclo(L-neopentylglycyl-L-prolyl) (IXa) and cyclo(D-neopentylglycyl-L-prolyl) (IXb) and also N-acetyl-L-neopentylglycine methylamide (X) were prepared as models for further studies on physical properties and conformation of peptides.
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20

Grelich-Mucha, Manuela, Ana M. Garcia, Vladimir Torbeev, Katarzyna Ożga, Łukasz Berlicki, and Joanna Olesiak-Bańska. "Autofluorescence of Amyloids Determined by Enantiomeric Composition of Peptides." Journal of Physical Chemistry B 125, no. 21 (2021): 5502–10. http://dx.doi.org/10.1021/acs.jpcb.1c00808.

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21

Wan, Hong, and Lars G. Blomberg. "Enantiomeric separation of small chiral peptides by capillary electrophoresis." Journal of Chromatography A 792, no. 1-2 (1997): 393–400. http://dx.doi.org/10.1016/s0021-9673(97)00976-x.

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22

Yamagata, Natsuko, Xiaoyi Chen, Jie Zhou, Jie Li, Xuewen Du, and Bing Xu. "Enzymatic self-assembly of an immunoreceptor tyrosine-based inhibitory motif (ITIM)." Organic & Biomolecular Chemistry 15, no. 27 (2017): 5689–92. http://dx.doi.org/10.1039/c7ob01074e.

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An immunoreceptor tyrosine-based inhibitory motif (ITIM), LYYYYL, as well as its enantiomeric or retro-inverso peptide, self-assembles in water upon enzymatic dephosphorylation, thus illustrating a new approach to design bioinspired soft materials from an important pool of functional peptides.
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23

Bartnik, Dirk, Susanne Aileen Funke, Luminita-Cornelia Andrei-Selmer, Michael Bacher, Richard Dodel та Dieter Willbold. "Differently Selected d-Enantiomeric Peptides Act on Different Aβ Species". Rejuvenation Research 13, № 2-3 (2010): 202–5. http://dx.doi.org/10.1089/rej.2009.0924.

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24

Tao, W. Andy, and R. Graham Cooks. "Parallel Reactions for Enantiomeric Quantification of Peptides by Mass Spectrometry." Angewandte Chemie 113, no. 4 (2001): 779–82. http://dx.doi.org/10.1002/1521-3757(20010216)113:4<779::aid-ange7790>3.0.co;2-d.

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25

Tao, W. Andy, and R. Graham Cooks. "Parallel Reactions for Enantiomeric Quantification of Peptides by Mass Spectrometry." Angewandte Chemie International Edition 40, no. 4 (2001): 757–60. http://dx.doi.org/10.1002/1521-3773(20010216)40:4<757::aid-anie7570>3.0.co;2-h.

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26

Deigin, Vladislav, Natalia Linkova, Julia Vinogradova, et al. "The First Reciprocal Activities of Chiral Peptide Pharmaceuticals: Thymogen and Thymodepressin, as Examples." International Journal of Molecular Sciences 25, no. 9 (2024): 5042. http://dx.doi.org/10.3390/ijms25095042.

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Peptides show high promise in the targeting and intracellular delivery of next-generation biotherapeutics. The main limitation is peptides’ susceptibility to proteolysis in biological systems. Numerous strategies have been developed to overcome this challenge by chemically enhancing the resistance to proteolysis. In nature, amino acids, except glycine, are found in L- and D-enantiomers. The change from one form to the other will change the primary structure of polypeptides and proteins and may affect their function and biological activity. Given the inherent chiral nature of biological systems
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27

Kolkwitz, Pauline Elisabeth, Jeannine Mohrlüder, and Dieter Willbold. "Inhibition of Polyglutamine Misfolding with D-Enantiomeric Peptides Identified by Mirror Image Phage Display Selection." Biomolecules 12, no. 2 (2022): 157. http://dx.doi.org/10.3390/biom12020157.

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Nine heritable diseases are known that are caused by unphysiologically elongated polyglutamine tracts in human proteins leading to misfolding, aggregation and neurodegeneration. Current therapeutic strategies include efforts to inhibit the expression of the respective gene coding for the polyglutamine-containing proteins. There are, however, concerns that this may interfere with the physiological function of the respective protein. We aim to stabilize the protein’s native conformation by D-enantiomeric peptide ligands to prevent misfolding and aggregation, shift the equilibrium between aggrega
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28

Simaan, Marwan, and Ilan Marek. "Diastereo- and enantioselective preparation of cyclopropanol derivatives." Beilstein Journal of Organic Chemistry 15 (March 21, 2019): 752–60. http://dx.doi.org/10.3762/bjoc.15.71.

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The diastereoselective carbocupration reaction of alkoxy-functionalized cyclopropene derivatives, followed by a subsequent trapping of the resulting cyclopropylmetal species with an electrophilic source of oxygen (oxenoid) afforded various tetrasubstituted cyclopropanol derivatives in high diastereo- and enantiomeric ratios. Similarly, the enantioselective copper-catalyzed carbomagnesiation/oxidation (or amination) sequence on achiral nonfunctionalized cyclopropenes provided the desired cyclopropanol (and cyclopropylamine) derivatives in excellent diastereo- and enantiomeric excesses.
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29

Parveen, Sabiha, J. A. Cowan, Zhen Yu, and Farukh Arjmand. "Enantiomeric copper based anticancer agents promoting sequence-selective cleavage of G-quadruplex telomeric DNA and non-random cleavage of plasmid DNA." Metallomics 12, no. 6 (2020): 988–99. http://dx.doi.org/10.1039/d0mt00084a.

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30

Chen, Ming, Shuanglong Wang, and Xihan Yu. "Cryptand-imidazolium supported total synthesis of the lasso peptide BI-32169 and its d-enantiomer." Chemical Communications 55, no. 23 (2019): 3323–26. http://dx.doi.org/10.1039/c8cc10301a.

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The first total synthesis of natural lasso peptide is reported, in which cryptand-imidazolium complex support manipulates the peptide chain to achieve a lasso peptide configuration of BI-32169. Moreover, the synthesis of d-enantiomeric lasso peptide via this new method opens up new horizons in the study of lasso peptides.
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31

Vieira, Lucas C. C., Bianca T. Matsuo, Lorena S. R. Martelli, Mayara Gall, Marcio W. Paixão та Arlene G. Corrêa. "Asymmetric synthesis of new γ-butenolides via organocatalyzed epoxidation of chalcones". Organic & Biomolecular Chemistry 15, № 29 (2017): 6098–103. http://dx.doi.org/10.1039/c7ob00165g.

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32

Gandhapudi, Siva K., Karuna Sundarapandiyan, Martin Ward, et al. "Abstract B24: Development of targeted T-cell cancer immunotherapies based on a novel enantiomeric cationic lipid that promotes antigen cross-presentation and upregulation of type I interferons." Cancer Immunology Research 10, no. 12_Supplement (2022): B24. http://dx.doi.org/10.1158/2326-6074.tumimm22-b24.

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Abstract The enantiomeric cationic lipid R-DOTAP nanoparticle platform (Versamune®) was reported (Gandhapudi et. al. 2019, J. Immunol.) to promote cross presentation of multi-epitope human papilloma virus (HPV) antigens and upregulation of Type I interferons, leading to induction of high levels of antigen-specific cytolytic polyfuctional CD8+ T-cells in vivo and complete regression of TC-1 tumors in preclinical models. In two ongoing Phase 2 human clinical trials (ASCO 2022), the early data in a group of the first 60 patients receiving PDS0101 (Versamune® plus HPV16 peptide mix) and who had pr
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33

IWASAKI, Takashi, Jun ISHIBASHI, Masanori KUBO, DeMar TAYLOR, and Minoru YAMAKAWA. "Multiple Functions of Short Synthetic Enantiomeric Peptides Based on Beetle Defensins." Bioscience, Biotechnology, and Biochemistry 73, no. 3 (2009): 683–87. http://dx.doi.org/10.1271/bbb.80735.

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34

Funke, Susanne, Christina Dammers, Marcus Pickhardt, Dieter Willbold, and Eckhard Mandelkow. "Tau-specific D-enantiomeric peptides for therapeutic applications in Alzheimer’s disease." Neurobiology of Aging 39 (March 2016): S13. http://dx.doi.org/10.1016/j.neurobiolaging.2016.01.066.

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35

Barone, G., G. Castronuovo, V. Elia, and C. Giancola. "Chiral recognition of enantiomeric peptides in water at 25° by calorimetry." Journal of Thermal Analysis 30, no. 6 (1985): 1367–74. http://dx.doi.org/10.1007/bf01914308.

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36

Gottlieb, Philip A., Mohammed M. Maneshi, Frederick Sachs та Susan Z. Hua. "Enantiomeric Aβ Peptides Inhibit the Fluid Shear Stress Response of PIEZO1". Biophysical Journal 116, № 3 (2019): 460a. http://dx.doi.org/10.1016/j.bpj.2018.11.2483.

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37

Saha, Indranil, Bhaswati Chatterjee, Narayanaswamy Shamala, and Padmanabhan Balaram. "Crystal structures of peptide enantiomers and racemates: Probing conformational diversity in heterochiral Pro-Pro sequences." Biopolymers 90, no. 4 (2008): 537–43. http://dx.doi.org/10.1002/bip.20982.

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38

Chen, Yuxin, Adriana I. Vasil, Linda Rehaume, et al. "Comparison of Biophysical and Biologic Properties of alpha-Helical Enantiomeric Antimicrobial Peptides." Chemical Biology Drug Design 67, no. 2 (2006): 162–73. http://dx.doi.org/10.1111/j.1747-0285.2006.00349.x.

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39

Swanekamp, Ria J., John T. M. DiMaio, Charles J. Bowerman та Bradley L. Nilsson. "Coassembly of Enantiomeric Amphipathic Peptides into Amyloid-Inspired Rippled β-Sheet Fibrils". Journal of the American Chemical Society 134, № 12 (2012): 5556–59. http://dx.doi.org/10.1021/ja301642c.

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40

Gottlieb, Philip A., Mohammad M. Maneshi, Radhakrishnan Gnanasambandam, Susan Z. Hua, and Frederick Sachs. "Enantiomeric Forms of Abeta Peptides Inhibit the Shear Stress Response of PIEZO1." Biophysical Journal 112, no. 3 (2017): 533a. http://dx.doi.org/10.1016/j.bpj.2016.11.2884.

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41

Marelli, Udaya Kiran, Jacqueline Bezençon, Eduard Puig, Beat Ernst, and Horst Kessler. "Enantiomeric Cyclic Peptides with Different Caco-2 Permeability Suggest Carrier-Mediated Transport." Chemistry - A European Journal 21, no. 22 (2015): 8023–27. http://dx.doi.org/10.1002/chem.201501270.

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42

Altendorf, Tim, Ian Gering, Beatrix Santiago-Schübel, et al. "Stabilization of Monomeric Tau Protein by All D-Enantiomeric Peptide Ligands as Therapeutic Strategy for Alzheimer’s Disease and Other Tauopathies." International Journal of Molecular Sciences 24, no. 3 (2023): 2161. http://dx.doi.org/10.3390/ijms24032161.

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Alzheimer’s disease and other tauopathies are the world’s leading causes of dementia and memory loss. These diseases are thought to be caused by the misfolding and aggregation of the intracellular tau protein, ultimately leading to neurodegeneration. The tau protein is involved in a multitude of different neurodegenerative diseases. During the onset of tauopathies, tau undergoes structural changes and posttranslational modifications and aggregates into amyloid fibrils that are able to spread with a prion-like behavior. Up to now, there is no therapeutic agent which effectively controls or reve
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43

Krasnov, Victor P., Galina L. Levit, Vera V. Musiyak, Dmitry A. Gruzdev, and Valery N. Charushin. "Fragment-based approach to novel bioactive purine derivatives." Pure and Applied Chemistry 92, no. 8 (2020): 1277–95. http://dx.doi.org/10.1515/pac-2019-1214.

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AbstractUsing purine as a scaffold, the methods for preparation of novel 2-aminopurine and purine derivatives substituted at position C6 by the fragments of natural amino acids, short peptides, and N-heterocycles, including enantiopure ones, have been proposed. The methods for determination of the enantiomeric purity of the obtained chiral compounds have been developed. Conjugates exhibiting high antimycobacterial or anti-herpesvirus activity against both laboratory and multidrug-resistant strains were revealed among the obtained compounds.
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44

Gilbert, AT, and EOP Thompson. "Amino Acid Sequence of the ß-Chain of the Tetrameric Haemoglobin of the Bivalve Mollusc, Anadara trapezia." Australian Journal of Biological Sciences 38, no. 3 (1985): 221. http://dx.doi.org/10.1071/bi9850221.

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The amino acid sequence of the iJ-chain of the principal haemoglobin from A. trapezia has been determined. The sequence was deduced from the sequences of tryptic peptides, which were fractionated using highperformance liquid chromatography and peptide mapping. Additional sequence data, particularly for the large tryptic peptides, was obtained from enzyme digests of both cyanogen bromide fragments and large citraconyitryptic peptides.
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45

Kanduc, Darja. "Peptimmunology: Immunogenic Peptides and Sequence Redundancy." Current Drug Discovery Technologies 2, no. 4 (2005): 239–44. http://dx.doi.org/10.2174/157016305775202946.

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46

Couceiro, José R., Rodrigo Gallardo, Frederik De Smet, et al. "Sequence-dependent Internalization of Aggregating Peptides." Journal of Biological Chemistry 290, no. 1 (2014): 242–58. http://dx.doi.org/10.1074/jbc.m114.586636.

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Meyer, Helmut E., Edeltraut Hoffmann-Posorske, Horst Korte, and Ludwig M. G. Heilmeyer. "Sequence analysis of phosphoserine-containing peptides." FEBS Letters 204, no. 1 (1986): 61–66. http://dx.doi.org/10.1016/0014-5793(86)81388-6.

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Janairo, Jose Isagani B. "Sequence rules for gold-binding peptides." RSC Advances 13, no. 31 (2023): 21146–52. http://dx.doi.org/10.1039/d3ra04269c.

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Classification based on association rules was applied to a dataset of decapeptides and their binding affinities for AuNPs. The sequence rules can accurately differentiate high-binding from low-binding affinity peptides.
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Bacik, I., J. H. Cox, R. Anderson, J. W. Yewdell, and J. R. Bennink. "TAP (transporter associated with antigen processing)-independent presentation of endogenously synthesized peptides is enhanced by endoplasmic reticulum insertion sequences located at the amino- but not carboxyl-terminus of the peptide." Journal of Immunology 152, no. 2 (1994): 381–87. http://dx.doi.org/10.4049/jimmunol.152.2.381.

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Abstract Under most circumstances, cell surface MHC class I molecules display peptides derived from a cytosolic pool of proteins. The efficient presentation of such peptides requires the functioning of two MHC gene products [TAP1 and TAP2 (transporter-associated with Ag processing 1 and 2)] that form a complex that facilitates transmembrane movement of peptides from the cytosol to the endoplasmic reticulum, the site of peptide association with class I molecules. It has been previously shown that peptides can be presented in a TAP-independent manner in association with HLA A2.1 or H-2 Kd if the
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Pérez‐Victoria, Ignacio. "Co‐occurring Congeners Reveal the Position of Enantiomeric Amino Acids in Nonribosomal Peptides." ChemBioChem 22, no. 12 (2021): 2087–92. http://dx.doi.org/10.1002/cbic.202000805.

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