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Journal articles on the topic 'Peptidic synthesis'

Author: Grafiati
Published: 4 June 2021
Last updated: 10 March 2023

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1

Collar, Aarón Gutiérrez, and Tanja Gulder. "Peptidic catalysts for macrocycle synthesis." Science 366, no. 6472 (December 19, 2019): 1454. http://dx.doi.org/10.1126/science.aaz9325.

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2

Chronopoulou, Laura, Silvia Lorenzoni, Giancarlo Masci, Mariella Dentini, Anna Rita Togna, Giuseppina Togna, Federico Bordi, and Cleofe Palocci. "Lipase-supported synthesis of peptidic hydrogels." Soft Matter 6, no. 11 (2010): 2525. http://dx.doi.org/10.1039/c001658f.

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3

Surís-Valls and Voets. "Peptidic Antifreeze Materials: Prospects and Challenges." International Journal of Molecular Sciences 20, no. 20 (October 17, 2019): 5149. http://dx.doi.org/10.3390/ijms20205149.

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Necessitated by the subzero temperatures and seasonal exposure to ice, various organisms have developed a remarkably effective means to survive the harsh climate of their natural habitats. Their ice-binding (glyco)proteins keep the nucleation and growth of ice crystals in check by recognizing and binding to specific ice crystal faces, which arrests further ice growth and inhibits ice recrystallization (IRI). Inspired by the success of this adaptive strategy, various approaches have been proposed over the past decades to engineer materials that harness these cryoprotective features. In this review we discuss the prospects and challenges associated with these advances focusing in particular on peptidic antifreeze materials both identical and akin to natural ice-binding proteins (IBPs). We address the latest advances in their design, synthesis, characterization and application in preservation of biologics and foods. Particular attention is devoted to insights in structure-activity relations culminating in the synthesis of de novo peptide analogues. These are sequences that resemble but are not identical to naturally occurring IBPs. We also draw attention to impactful developments in solid-phase peptide synthesis and ‘greener’ synthesis routes, which may aid to overcome one of the major bottlenecks in the translation of this technology: unavailability of large quantities of low-cost antifreeze materials with excellent IRI activity at (sub)micromolar concentrations.
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4

Dood, Dharmpal S., Alan P. Kozikowski, Bernadette Cusack, and Elliott Richelson. "Synthesis of partially non-peptidic neurotensin mimetics." Bioorganic & Medicinal Chemistry Letters 4, no. 10 (May 1994): 1241–46. http://dx.doi.org/10.1016/s0960-894x(01)80338-3.

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5

Bird, Michael J., Anthony P. Silvestri, and Philip E. Dawson. "Expedient on-resin synthesis of peptidic benzimidazoles." Bioorganic & Medicinal Chemistry Letters 28, no. 16 (September 2018): 2679–81. http://dx.doi.org/10.1016/j.bmcl.2018.04.062.

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6

Baell, Jonathan B., Peter J. Duggan, and Y. Phei Lok. "ω-Conotoxins and Approaches to Their Non-Peptide Mimetics." Australian Journal of Chemistry 57, no. 3 (2004): 179. http://dx.doi.org/10.1071/ch03242.

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ω-Conotoxins are an interesting class of naturally occurring peptides that induce dramatic effects on the central nervous system (CNS). They have been shown to interfere with the normal function of neuronal calcium channels and can act as non-addictive analgesics. The usual problems associated with the delivery of peptidic therapeutics have led to efforts to produce non-peptidic mimetics of ω-conotoxins. Identification of the key amino-acid residues responsible for the physiological effects of the ω-conotoxins MVIIA and GVIA has allowed the design and synthesis of compounds that bind to neuronal calcium channels at low micromolar concentrations. These mimics bear the side chains of three amino acids that project from central scaffolds in similar ways to critical side chains of the conotoxins they simulate. Several useful leads have been identified, some of which show selectivity for N-type calcium channels.
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7

Albin, John S., and Bradley L. Pentelute. "Efficient Flow Synthesis of Human Antimicrobial Peptides." Australian Journal of Chemistry 73, no. 4 (2020): 380. http://dx.doi.org/10.1071/ch20043.

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Organisms from all kingdoms of life have evolved a vast array of peptidic natural products to defend against microbes. These are known collectively as antimicrobial peptides (AMPs) or host defence peptides, reflecting their abilities not only to directly kill microbes, but also to modulate host immune responses. Despite decades of investigation, AMPs have yet to live up to their promise as lead therapeutics, a reality that reflects, in part, our incomplete understanding of these diverse agents in their various physiological contexts. Towards improving our understanding of AMP biology and the ways in which this can be best leveraged for therapeutic development, we are interested in large-scale comparisons of the antimicrobial and immunological activities of human AMPs, an undertaking that requires an efficient workflow for AMP synthesis and subsequent characterization. We describe here the application of flow chemistry and reverse-phase flash chromatography to the generation of 43AMPs, approaches that, when combined, significantly expedite synthesis and purification, potentially facilitating more systematic approaches to downstream testing and engineering.
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8

Keen, Stephen P., Cameron J. Cowden, Brian C. Bishop, Karel M. J. Brands, Antony J. Davies, Ulf H. Dolling, David R. Lieberman, and Gavin W. Stewart. "Practical Asymmetric Synthesis of a Non-Peptidic αvβ3Antagonist." Journal of Organic Chemistry 70, no. 5 (March 2005): 1771–79. http://dx.doi.org/10.1021/jo048082n.

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9

Ciapetti, Paola, André Mann, Angèle Schoenfelder, Maurizio Taddei, Elisabeth Trifilieff, Isabelle Canet, and Jean Louis Canet. "Design and synthesis of chiral peptidic nucleic acids." Letters in Peptide Science 4, no. 4-6 (December 1997): 341–49. http://dx.doi.org/10.1007/bf02442898.

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10

Peddie, Victoria, Raymond J. Butcher, Ward T. Robinson, Matthew C. J. Wilce, Daouda A. K. Traore, and Andrew D. Abell. "Synthesis and Conformation of Fluorinated β-Peptidic Compounds." Chemistry - A European Journal 18, no. 21 (April 19, 2012): 6655–62. http://dx.doi.org/10.1002/chem.201200313.

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11

Yuan, Dan, Xuewen Du, Junfeng Shi, Ning Zhou, Abdulgader Ahmed Baoum, Khalid Omar Al Footy, Khadija Omar Badahdah, and Bing Xu. "Synthesis and evaluation of the biostability and cell compatibility of novel conjugates of nucleobase, peptidic epitope, and saccharide." Beilstein Journal of Organic Chemistry 11 (August 3, 2015): 1352–59. http://dx.doi.org/10.3762/bjoc.11.145.

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This article reports the synthesis of a new class of conjugates containing a nucleobase, a peptidic epitope, and a saccharide and the evalution of their gelation, biostability, and cell compatibility. We demonstrate a facile synthetic process, based on solid-phase peptide synthesis of nucleopeptides, to connect a saccharide with the nucleopeptides for producing the target conjugates. All the conjugates themselves (1–8) display excellent solubility in water without forming hydrogels. However, a mixture of 5 and 8 self-assembles to form nanofibers and results in a supramolecular hydrogel. The proteolytic stabilities of the conjugates depend on the functional peptidic epitopes. We found that TTPV is proteolytic resistant and LGFNI is susceptible to proteolysis. In addition, all the conjugates are compatible to the mammalian cells tested.
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12

Lesma, Giordano, Ivan Bassanini, Roberta Bortolozzi, Chiara Colletto, Ruoli Bai, Ernest Hamel, Fiorella Meneghetti, et al. "Complementary isonitrile-based multicomponent reactions for the synthesis of diversified cytotoxic hemiasterlin analogues." Organic & Biomolecular Chemistry 13, no. 48 (2015): 11633–44. http://dx.doi.org/10.1039/c5ob01882j.

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13

Liu, Dake, Garret M. Rubin, Dipesh Dhakal, Manyun Chen, and Yousong Ding. "Biocatalytic synthesis of peptidic natural products and related analogues." iScience 24, no. 5 (May 2021): 102512. http://dx.doi.org/10.1016/j.isci.2021.102512.

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14

Wu, Yong-Qian, Sergei Belyakov, Chi Choi, David Limburg, Thomas, Mark Vaal, Ling Wei, et al. "Synthesis and Biological Evaluation of Non-Peptidic Cyclophilin Ligands." Journal of Medicinal Chemistry 46, no. 7 (March 2003): 1112–15. http://dx.doi.org/10.1021/jm020409u.

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15

Sato, Koji, Noriyasu Hada, and Tadahiro Takeda. "Synthesis of new peptidic glycoclusters derived from β-alanine." Tetrahedron Letters 44, no. 52 (December 2003): 9331–35. http://dx.doi.org/10.1016/j.tetlet.2003.10.073.

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16

Halim, Dany, Karine Caron, and Jeffrey W. Keillor. "Synthesis and evaluation of peptidic maleimides as transglutaminase inhibitors." Bioorganic & Medicinal Chemistry Letters 17, no. 2 (January 2007): 305–8. http://dx.doi.org/10.1016/j.bmcl.2006.10.061.

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17

Farèse, Audrey, Nadia Patino, Roger Condom, Sandrine Dalleu, and Roger Guedj. "Liquid phase synthesis of a peptidic nucleic acid dimer." Tetrahedron Letters 37, no. 9 (February 1996): 1413–16. http://dx.doi.org/10.1016/0040-4039(96)00037-8.

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18

Choppin, Sabine, Marie Barbarotto, Michel Obringer, and Françoise Colobert. "Synthesis of an Advanced Fragment of (+)-Trienomycinol." Synthesis 48, no. 19 (August 18, 2016): 3263–71. http://dx.doi.org/10.1055/s-0035-1562735.

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The synthesis of the fully functionalized eastern fragment of trienomycins A–F, ansamycin antibiotics is described. A key step involves a peptidic coupling between a sulfonyl aniline and an enantiopure carboxylic acid obtained by a completely diastereoselective reduction of a β-ketosulfoxide to generate the stereogenic carbinol. Studies on the coupling with the western part were also performed, giving access to an advanced fragment of trienomycinol.
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19

Kumar, Sonu, Rituparna Acharya, Urmi Chatterji, and Priyadarsi De. "Controlled synthesis of β-sheet polymers based on side-chain amyloidogenic short peptide segments via RAFT polymerization." Polym. Chem. 5, no. 20 (2014): 6039–50. http://dx.doi.org/10.1039/c4py00620h.

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A strategy was developed for the controlled synthesis of side-chain peptide containing pH-responsive polymers with an antiparallel β-sheet motif, which was independent of solvent polarity, PEGylation of homopolymers, the block length of PEG or peptidic segments in the block copolymer and temperature.
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20

Gille, Franziska, and Andreas Kirschning. "Studies on the synthesis of peptides containing dehydrovaline and dehydroisoleucine based on copper-mediated enamide formation." Beilstein Journal of Organic Chemistry 12 (March 22, 2016): 564–70. http://dx.doi.org/10.3762/bjoc.12.55.

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The preparation of peptide fragments containing dehydrovaline and dehydroisoleucine moieties present in the antibiotic myxovalargin is reported. Peptide formation is based on a copper-mediated C–N cross-coupling protocol between an acyl amide and a peptidic vinyl iodide. The presence of a neighboring arginine in the vinyl iodide posed a challenge with respect to the choice of the protecting group and the reaction conditions. It was found that ornithine – a suitable precursor – is better suited than arginine for achieving good yields for the C–N cross-coupling reaction. The optimized conditions were utilized for the synthesis of peptides 32, 33, 39 and 40 containing a neighboring ornithine as well as for the tripeptide 44 containing dehydroisoleucine with the correct stereochemistry.
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21

Gavrilyuk, Julia I., Ghotas Evindar, Jin Yu Chen, and Robert A. Batey. "Peptide-Heterocycle Hybrid Molecules: Solid-Phase-Supported Synthesis of SubstitutedN-Terminal 5-Aminotetrazole Peptides via Electrocyclization of Peptidic Imidoylazides." Journal of Combinatorial Chemistry 9, no. 4 (July 2007): 644–51. http://dx.doi.org/10.1021/cc060119p.

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22

Ding, Yili, Chamakura Vara Prasad, Kenneth Smith, Eugene Chang, Jian Hong, and Nanhua Yao. "Synthesis of Tipranavir Analogues as Non-Peptidic HIV Protease Inhibitors." Letters in Organic Chemistry 6, no. 2 (March 1, 2009): 130–33. http://dx.doi.org/10.2174/157017809787582807.

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23

Lorthioir, J. C. Truffert, D. Sy, B. Barbier, D. Lelievre, and A. Brack. "Computer Design, Synthesis and Hydrolytic Activity of Peptidic Artificial Ribonucleases." Protein & Peptide Letters 3, no. 3 (June 1996): 153–60. http://dx.doi.org/10.2174/092986650303220614163113.

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An RNA cleaving catalyst combined to an antisense DNA may represent a new approach for gene targeted . therapy . As cleaving agents, we used basic polypeptides under the -sheet or a.-helix conformations. Molecular modeling studies were used in an attempt to design a second generation of artificial ribonucleases, taking into account the three-dimensional arrangement of functional groups in the peptide/RNA complexes. Such computer aid in rational design processes appears as an original and promising approach .
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24

Castex, Cédric, Christophe Lalanne, Patrick Mouchet, Marc Lemaire, and Roger Lahana. "Regioselective synthesis of peptidic derivatives and glycolamidic esters of Methotrexate." Tetrahedron 61, no. 4 (January 2005): 803–12. http://dx.doi.org/10.1016/j.tet.2004.11.049.

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25

Amarasinghe, Kande K. D., Artem G. Evidokimov, Kevin Xu, Cynthia M. Clark, Matthew B. Maier, Anil Srivastava, Anny-Odile Colson, et al. "Design and synthesis of potent, non-peptidic inhibitors of HPTPβ." Bioorganic & Medicinal Chemistry Letters 16, no. 16 (August 2006): 4252–56. http://dx.doi.org/10.1016/j.bmcl.2006.05.074.

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26

Weiss, Stefan, Max Keller, Günther Bernhardt, Armin Buschauer, and Burkhard König. "Modular synthesis of non-peptidic bivalent NPY Y1 receptor antagonists." Bioorganic & Medicinal Chemistry 16, no. 22 (November 2008): 9858–66. http://dx.doi.org/10.1016/j.bmc.2008.09.033.

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27

Monaco, Alessandra, Olivier Michelin, John Prior, Curzio Rüegg, Leonardo Scapozza, and Yann Seimbille. "Synthesis of a non-peptidic PET tracer designed forα5β1integrin receptor." Journal of Labelled Compounds and Radiopharmaceuticals 57, no. 5 (March 14, 2014): 365–70. http://dx.doi.org/10.1002/jlcr.3190.

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28

Verlinden, Steven, Steven Ballet, and Guido Verniest. "Synthesis of Heterocycle-Bridged Peptidic Macrocycles through 1,3-Diyne Transformations." European Journal of Organic Chemistry 2016, no. 35 (November 21, 2016): 5807–12. http://dx.doi.org/10.1002/ejoc.201601215.

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29

Pardin, Christophe, Steve M. F. G. Gillet, and Jeffrey W. Keillor. "Synthesis and evaluation of peptidic irreversible inhibitors of tissue transglutaminase." Bioorganic & Medicinal Chemistry 14, no. 24 (December 2006): 8379–85. http://dx.doi.org/10.1016/j.bmc.2006.09.011.

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30

Szymanski, Wiktor, Magdalena Zwolinska, Szymon Klossowski, Izabela Młynarczuk-Biały, Łukasz Biały, Tadeusz Issat, Jacek Malejczyk, and Ryszard Ostaszewski. "Synthesis of novel, peptidic kinase inhibitors with cytostatic/cytotoxic activity." Bioorganic & Medicinal Chemistry 22, no. 5 (March 2014): 1773–81. http://dx.doi.org/10.1016/j.bmc.2014.01.005.

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31

Bąchor, Remigiusz, Alicja Kluczyk, Piotr Stefanowicz, and Zbigniew Szewczuk. "Synthesis and mass spectrometry analysis of quaternary cryptando-peptidic conjugates." Journal of Peptide Science 21, no. 12 (October 25, 2015): 879–86. http://dx.doi.org/10.1002/psc.2830.

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32

Kemper, Benedict, Yana R. Hristova, Sebastian Tacke, Linda Stegemann, Laura S. van Bezouwen, Marc C. A. Stuart, Jürgen Klingauf, Cristian A. Strassert, and Pol Besenius. "Facile synthesis of a peptidic Au(i)-metalloamphiphile and its self-assembly into luminescent micelles in water." Chemical Communications 51, no. 25 (2015): 5253–56. http://dx.doi.org/10.1039/c4cc03868a.

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We report a short synthetic route for the preparation of a peptidic Au(i)-metalloamphiphile which, in buffered environments of physiological ionic strength, self-assembles into luminescent micellar nanostructures of 14 nm in diameter.
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33

Inguimbert, N., P. Coric, H. Dhotel, E. Bonnard, C. Llorens-Cortes, N. Mota, M. C. Fournié-Zaluski, and B. P. Roques. "Synthesis and in vitro activities of new non-peptidic APA Inhibitors." Journal of Peptide Research 65, no. 2 (December 5, 2008): 175–88. http://dx.doi.org/10.1111/j.1399-3011.2004.00211.x.

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34

Martin, Fionna M., R. Paul Beckett, Claire L. Bellamy, Paul F. Courtney, Stephen J. Davies, Alan H. Drummond, Rory Dodd, et al. "The synthesis and biological evaluation of non-peptidic matrix metalloproteinase inhibitors." Bioorganic & Medicinal Chemistry Letters 9, no. 19 (October 1999): 2887–92. http://dx.doi.org/10.1016/s0960-894x(99)00494-1.

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35

Arnusch, Christopher J., and Roland J. Pieters. "Synthesis of a novel 14-membered highly constrained cyclic peptidic scaffold." Tetrahedron Letters 45, no. 21 (May 2004): 4153–56. http://dx.doi.org/10.1016/j.tetlet.2004.03.131.

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36

Jaskiewicz, E., M. Czerwinski, D. Syper, and E. Lisowska. "Anti-M monoclonal antibodies cross-reacting with variant Mg antigen: an example of modulation of antigenic properties of peptide by its glycosylation." Blood 84, no. 7 (October 1, 1994): 2340–45. http://dx.doi.org/10.1182/blood.v84.7.2340.2340.

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Abstract Some monoclonal antibodies (MoAbs) directed against blood group M- related epitope of glycophorin A (GPA) were found to agglutinate rare variant erythrocytes carrying GPA of Mg type. In contradistinction to normal GPA-M or -N, the N-terminal portion of GPA-Mg is not glycosylated. Therefore, the multipin peptide synthesis was used for testing the specificity of the cross-reacting MoAbs. Among several anti- M and anti-N MoAbs tested, only three anti-M (E3, E6, 425/2B) agglutinated Mg erythrocytes and showed binding to the synthetic octapeptides corresponding to N-terminal sequences of GPA-M (SSTTGVAM), GPA-N (LSTTEVAM), and GPA-Mg (LSTNEVAM). Testing multiple peptide analogs (window and replacement analysis) showed that these MoAbs were specific for peptidic epitope in which Met8 and Val6 were the most essential amino acid residues. The amino acid replacements Ser<-->Leu1 or Gly<-->Glu5 (M v N) and Thr<-->Asn4 (M and N v Mg) had no or negligible effect on the reaction of synthetic peptides with the MoAbs. However, when Ser2, Thr3, and Thr4 carry O-linked sialooligosaccharides (normal GPA-M or -N), the MoAbs recognize Gly5- and sialic acid- dependent blood group M-related epitope. An interesting finding concerning anti-M/Mg MoAbs described here is the fact that glycosylation of amino acid residues adjacent to the most important part of peptidic epitope not only differentially modulates the proper exposure of peptidic epitope, but also alters the requirement for some amino acid residues present within the epitope. Pathologic conditions, including hematologic disorders, are often accompanied by alterations in protein glycosylation, resulting not only from differences in the structure of antigen polypeptide chain, but also from changes in specificity or expression of enzymes involved in glycosylation. Our present findings draw attention to possibility of the bidirectional modulation of protein antigenicity by glycosylation and may be helpful in interpretation of some results obtained with MoAb used for diagnostic or other purposes.
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37

Jaskiewicz, E., M. Czerwinski, D. Syper, and E. Lisowska. "Anti-M monoclonal antibodies cross-reacting with variant Mg antigen: an example of modulation of antigenic properties of peptide by its glycosylation." Blood 84, no. 7 (October 1, 1994): 2340–45. http://dx.doi.org/10.1182/blood.v84.7.2340.bloodjournal8472340.

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Some monoclonal antibodies (MoAbs) directed against blood group M- related epitope of glycophorin A (GPA) were found to agglutinate rare variant erythrocytes carrying GPA of Mg type. In contradistinction to normal GPA-M or -N, the N-terminal portion of GPA-Mg is not glycosylated. Therefore, the multipin peptide synthesis was used for testing the specificity of the cross-reacting MoAbs. Among several anti- M and anti-N MoAbs tested, only three anti-M (E3, E6, 425/2B) agglutinated Mg erythrocytes and showed binding to the synthetic octapeptides corresponding to N-terminal sequences of GPA-M (SSTTGVAM), GPA-N (LSTTEVAM), and GPA-Mg (LSTNEVAM). Testing multiple peptide analogs (window and replacement analysis) showed that these MoAbs were specific for peptidic epitope in which Met8 and Val6 were the most essential amino acid residues. The amino acid replacements Ser<-->Leu1 or Gly<-->Glu5 (M v N) and Thr<-->Asn4 (M and N v Mg) had no or negligible effect on the reaction of synthetic peptides with the MoAbs. However, when Ser2, Thr3, and Thr4 carry O-linked sialooligosaccharides (normal GPA-M or -N), the MoAbs recognize Gly5- and sialic acid- dependent blood group M-related epitope. An interesting finding concerning anti-M/Mg MoAbs described here is the fact that glycosylation of amino acid residues adjacent to the most important part of peptidic epitope not only differentially modulates the proper exposure of peptidic epitope, but also alters the requirement for some amino acid residues present within the epitope. Pathologic conditions, including hematologic disorders, are often accompanied by alterations in protein glycosylation, resulting not only from differences in the structure of antigen polypeptide chain, but also from changes in specificity or expression of enzymes involved in glycosylation. Our present findings draw attention to possibility of the bidirectional modulation of protein antigenicity by glycosylation and may be helpful in interpretation of some results obtained with MoAb used for diagnostic or other purposes.
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38

Bergeron, Raymond J., William R. Weimar, Ralf Müller, Curt O. Zimmerman, Bruce H. McCosar, Hua Yao, and Richard E. Smith. "Synthesis of Reagents for the Construction of Hypusine and Deoxyhypusine Peptides and Their Application as Peptidic Antigens." Journal of Medicinal Chemistry 41, no. 20 (September 1998): 3888–900. http://dx.doi.org/10.1021/jm980389p.

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39

Reisberg, Solomon H., Yang Gao, Allison S. Walker, Eric J. N. Helfrich, Jon Clardy, and Phil S. Baran. "Total synthesis reveals atypical atropisomerism in a small-molecule natural product, tryptorubin A." Science 367, no. 6476 (January 2, 2020): 458–63. http://dx.doi.org/10.1126/science.aay9981.

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Molecular shape defines function in both biological and material settings, and chemists have developed an ever-increasing vernacular to describe these shapes. Noncanonical atropisomers—shape-defined molecules that are formally topologically trivial but are interconvertible only by complex, nonphysical multibond torsions—form a unique subset of atropisomers that differ from both canonical atropisomers (e.g., binaphthyls) and topoisomers (i.e., molecules that have identical connectivity but nonidentical molecular graphs). Small molecules, in contrast to biomacromolecules, are not expected to exhibit such ambiguous shapes. Using total synthesis, we found that the peptidic alkaloid tryptorubin A can be one of two noncanonical atropisomers. We then devised a synthetic strategy that drives the atropospecific synthesis of a noncanonical atrop-defined small molecule.
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40

Cironi, Alvarez, Mercedes Alvarez, and Fernando Albericio. "Solid-Phase Chemistry in the Total Synthesis of Non-Peptidic Natural Products." Mini-Reviews in Medicinal Chemistry 6, no. 1 (January 1, 2006): 11–25. http://dx.doi.org/10.2174/138955706775197857.

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41

Mezrai, Abdelmoumen, David Lesur, Anne Wadouachi, Florence Pilard, and Joseph Kajima Mulengi. "The synthesis of a glucoconjugate of the peptidic fragment of cryptophycin-24." Mediterranean Journal of Chemistry 3, no. 4 (July 4, 2014): 935–46. http://dx.doi.org/10.13171/mjc.3.4.2014.04.07.15.

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42

Zheng, H., M. B. H. Youdim, L. M. Weiner, and M. Fridkin. "Synthesis and evaluation of peptidic metal chelators for neuroprotection in neurodegenerative diseases." Journal of Peptide Research 66, no. 4 (October 2005): 190–203. http://dx.doi.org/10.1111/j.1399-3011.2005.00289.x.

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43

Scanes, Robert J. H., Oleg Grossmann, André Grossmann, and David R. Spring. "Enantioselective Synthesis of Chromanones via a Peptidic Phosphane Catalyzed Rauhut–Currier Reaction." Organic Letters 17, no. 10 (April 27, 2015): 2462–65. http://dx.doi.org/10.1021/acs.orglett.5b00971.

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44

Righi, Giuliana, Claudia D'Achille, Giovanna Pescatore, and Carlo Bonini. "New stereoselective synthesis of the peptidic aminopeptidase inhibitors bestatin, phebestin and probestin." Tetrahedron Letters 44, no. 37 (September 2003): 6999–7002. http://dx.doi.org/10.1016/s0040-4039(03)01799-4.

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45

Valero, Julián, Michiel Van Gool, Ruth Pérez-Fernández, Pilar Castreño, Jorge Sánchez-Quesada, Pilar Prados, and Javier de Mendoza. "Non-peptidic cell-penetrating agents: synthesis of oligomeric chiral bicyclic guanidinium vectors." Organic & Biomolecular Chemistry 10, no. 28 (2012): 5417. http://dx.doi.org/10.1039/c2ob25467k.

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Sarabia, Francisco, Samy Chammaa, and Miguel García-Castro. "Synthetic Studies on Stevastelins. 2. Synthesis of Lipidic- and Peptidic-Modified Analogues." Journal of Organic Chemistry 70, no. 20 (September 2005): 7858–65. http://dx.doi.org/10.1021/jo050628y.

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Albrecht, Sébastien, Albert Defoin, Emmanuel Salomon, Céline Tarnus, Anders Wetterholm, and Jasper Z. Haeggström. "Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors." Bioorganic & Medicinal Chemistry 14, no. 21 (November 2006): 7241–57. http://dx.doi.org/10.1016/j.bmc.2006.06.050.

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Thérien, Michel, Kathryn Skorey, Robert Zamboni, Chun Sing Li, Cheuk K. Lau, Tammy LeRiche, Vouy Linh Truong, Deena Waddleton, and Chidambaram Ramachandran. "Synthesis of a novel peptidic photoaffinity probe for the PTP-1B enzyme." Bioorganic & Medicinal Chemistry Letters 14, no. 9 (May 2004): 2319–22. http://dx.doi.org/10.1016/j.bmcl.2004.01.101.

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Lenzen, Karst, Matteo Planchestainer, Isabelle Feller, David Roura Padrosa, Francesca Paradisi, and Martin Albrecht. "Minimalistic peptidic scaffolds harbouring an artificial carbene-containing amino acid modulate reductase activity." Chemical Communications 57, no. 72 (2021): 9068–71. http://dx.doi.org/10.1039/d1cc03158a.

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A non-natural histidinium amino acid has been developed and used for solid-phase peptide synthesis to construct a peptide iridium carbene conjugate as artificial mini-peptide for hydrogenation catalysis.
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Hollanders, Karlijn, Bert Maes, and Steven Ballet. "A New Wave of Amide Bond Formations for Peptide Synthesis." Synthesis 51, no. 11 (April 24, 2019): 2261–77. http://dx.doi.org/10.1055/s-0037-1611773.

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The construction of peptidic amide bonds has become a daily laboratory practice by virtue of well-established ‘coupling reagents’. Nonetheless, inherent limitations connected to these classical coupling methods in terms of waste, safety and expense have yet to be conquered. Research efforts have been devoted to synthetic methods able to surpass these limitations. This short review focuses on the advances made in these ‘non-classical’ methods for amide bond formation with a specific application in peptide chemistry. It consists of two main sections: (i) novel carboxylic activation reagents, and (ii) carboxylic acid and amine surrogates.1 Introduction2 Alternative Carboxylic acid Activation Reagents3 Carboxylic Acid and Amine Surrogates4 Conclusion and Perspectives
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