Academic literature on the topic 'Per Arnt Sim (PAS)'

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Journal articles on the topic "Per Arnt Sim (PAS)"

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Yang, Jinsong, Lei Zhang, Paul J. A. Erbel, et al. "Functions of the Per/ARNT/Sim Domains of the Hypoxia-inducible Factor." Journal of Biological Chemistry 280, no. 43 (2005): 36047–54. http://dx.doi.org/10.1074/jbc.m501755200.

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The heterodimeric transcription factor hypoxia-inducible factor (HIF) plays an important role in the progression of a number of processes in which O2 availability is compromised and, as such, has become an increasingly attractive therapeutic target. Although tremendous progress has been made in recent years in unraveling the mechanisms underlying O2-dependent regulation of HIF through its O2-dependent degradation domain and C-terminal transactivation domain, our understanding of the contributions of other structural elements, particularly the Per/ARNT/Sim (PAS)-A and PAS-B domains, to the acti
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Hirose, K., M. Morita, M. Ema, et al. "cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt)." Molecular and Cellular Biology 16, no. 4 (1996): 1706–13. http://dx.doi.org/10.1128/mcb.16.4.1706.

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We isolated mouse cDNA clones (Arnt2) that are highly similar to but distinct from the aryl hydrocarbon receptor (AhR) nuclear translocator (Arnt). The composite cDNA covered a 2,443-bp sequence consisting of a putative 2,136-bp open reading frame encoding a polypeptide of 712 amino acids. The predicted Arnt2 polypeptide carries a characteristic basic helix-loop-helix (bHLH)/PAS motif in its N-terminal region with close similarity (81% identity) to that of mouse Arnt and has an overall sequence identity of 57% with Arnt. Biochemical properties and interaction of Arnt2 with other bHLH/PAS prote
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Reisz-Porszasz, S., M. R. Probst, B. N. Fukunaga, and O. Hankinson. "Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT)." Molecular and Cellular Biology 14, no. 9 (1994): 6075–86. http://dx.doi.org/10.1128/mcb.14.9.6075-6086.1994.

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The activated aryl hydrocarbon receptor (AHR) and the AHR nuclear translocator (ARNT) bind DNA as a heterodimer. Both proteins represent a novel class of basic helix-loop-helix (bHLH)-containing transcription factors in that (i) activation of AHR requires the binding of ligand (e.g., 2,3,7,8-tetrachlorodibenzo-p-dioxin [TCDD]), (ii) the xenobiotic responsive element (XRE) recognized by the AHR/ARNT heterodimer differs from the recognition sequence for nearly all other bHLH proteins, and (iii) both proteins contain a PAS homology region, which in the Drosophila PER and SIM proteins functions as
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Reisz-Porszasz, S., M. R. Probst, B. N. Fukunaga, and O. Hankinson. "Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT)." Molecular and Cellular Biology 14, no. 9 (1994): 6075–86. http://dx.doi.org/10.1128/mcb.14.9.6075.

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The activated aryl hydrocarbon receptor (AHR) and the AHR nuclear translocator (ARNT) bind DNA as a heterodimer. Both proteins represent a novel class of basic helix-loop-helix (bHLH)-containing transcription factors in that (i) activation of AHR requires the binding of ligand (e.g., 2,3,7,8-tetrachlorodibenzo-p-dioxin [TCDD]), (ii) the xenobiotic responsive element (XRE) recognized by the AHR/ARNT heterodimer differs from the recognition sequence for nearly all other bHLH proteins, and (iii) both proteins contain a PAS homology region, which in the Drosophila PER and SIM proteins functions as
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Wang, Feng, Shengli Shi, Ruixue Zhang, and Oliver Hankinson. "Identifying target genes of the aryl hydrocarbon receptor nuclear translocator (Arnt) using DNA microarray analysis." Biological Chemistry 387, no. 9 (2006): 1215–18. http://dx.doi.org/10.1515/bc.2006.150.

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Abstract The aryl hydrocarbon receptor nuclear translocator (Arnt) is a basic helix-loop-helix (bHLH) protein that also contains a Per-Arnt-Sim (PAS) domain. In addition to forming heterodimers with many other bHLH-PAS proteins, including the aryl hydrocarbon receptor (AhR) and hypoxia-inducible factors 1α, 2α and 3α, Arnt can also form homodimers when expressed from its cDNA in vitro or in vivo. However, target genes of the Arnt/Arnt homodimer remain to be identified. In this study, we have elucidated the profile of genes responsive to the reintroduction of Arnt expression in an Arnt-deficien
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de Souza, João V., Sylvia Reznikov, Ruidi Zhu, and Agnieszka K. Bronowska. "Druggability assessment of mammalian Per–Arnt–Sim [PAS] domains using computational approaches." MedChemComm 10, no. 7 (2019): 1126–37. http://dx.doi.org/10.1039/c9md00148d.

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Moffett, P., M. Reece, and J. Pelletier. "The murine Sim-2 gene product inhibits transcription by active repression and functional interference." Molecular and Cellular Biology 17, no. 9 (1997): 4933–47. http://dx.doi.org/10.1128/mcb.17.9.4933.

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The Drosophila single-minded (Dsim) gene encodes a master regulatory protein involved in cell fate determination during midline development. This protein is a member of a rapidly expanding family of gene products possessing basic helix-loop-helix (bHLH) and hydrophobic PAS (designated a conserved region among PER, ARNT [aryl hydrocarbon receptor nuclear translocator] and SIM) protein association domains. Members of this family function as central transcriptional regulators in cellular differentiation and in the response to environmental stimuli such as xenobiotics and hypoxia. We have previous
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Pongratz, Ingemar, Camilla Antonsson, Murray L. Whitelaw, and Lorenz Poellinger. "Role of the PAS Domain in Regulation of Dimerization and DNA Binding Specificity of the Dioxin Receptor." Molecular and Cellular Biology 18, no. 7 (1998): 4079–88. http://dx.doi.org/10.1128/mcb.18.7.4079.

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ABSTRACT The dioxin receptor is a ligand-regulated transcription factor that mediates signal transduction by dioxin and related environmental pollutants. The receptor belongs to the basic helix-loop-helix (bHLH)–Per-Arnt-Sim (PAS) family of factors, which, in addition to the bHLH motif, contain a PAS region of homology. Upon activation, the dioxin receptor dimerizes with the bHLH-PAS factor Arnt, enabling the receptor to recognize xenobiotic response elements in the vicinity of target genes. We have studied the role of the PAS domain in dimerization and DNA binding specificity of the dioxin re
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Zhao, J. M., H. Lee, R. A. Nome, S. Majid, N. F. Scherer, and W. D. Hoff. "Single-molecule detection of structural changes during Per-Arnt-Sim (PAS) domain activation." Proceedings of the National Academy of Sciences 103, no. 31 (2006): 11561–66. http://dx.doi.org/10.1073/pnas.0601567103.

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MacDonald, P. E., and P. Rorsman. "Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon secretion." Diabetologia 54, no. 4 (2011): 719–21. http://dx.doi.org/10.1007/s00125-011-2072-1.

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Dissertations / Theses on the topic "Per Arnt Sim (PAS)"

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Pierrel, Fabien. "Modification des ARNt par une protéine " Radical SAM " : étude de la protéine MiaB." Université Joseph Fourier (Grenoble), 2004. http://www.theses.fr/2004GRE10106.

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Les ARNt sont des molécules clés de la machinerie traductionnelle puisqu'ils assurent le décodage exact des codons successifs de l'ARN messager (ARNm) au sein du ribosome, permettant ainsi la synthèse de la protéine correspondant à l'ARNm. Les ARNt matures ont une taille comprise entre 73 et 95 nucléotides dont beaucoup sont constitués de nucléosides modifiés (86 différents ont été identifiés). Nous nous sommes intéressés à l'un de ces nucléosides modifiés, la 2-méthylthio-N6-isopentenyladénosine (ms2i6A) présente en position 37 de certains ARNt. La biosynthèse de ms2i6A peut être divisée en 2
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Mazel, Vincent. "Analyse par imagerie chimique de mélanges hybrides : les patines rituelles de la statuaire dogon." Paris 6, 2006. http://www.theses.fr/2006PA066297.

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Rousseau, Diane. "Les procédés efficaces pour réduire l'anxiété provoquée par la prise de parole en public /." [Québec] : Faculté des sciences de l'éducation, Université Laval, 1998. http://proquest.umi.com/pqdweb?did=734670041&sid=38&Fmt=2&clientId=9268&RQT=309&VName=PQD.

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Rézeau, Joseph. "Médiatisation et médiation pédagogique dans un environnement multimédia : Le cas de l'apprentissage de l'anglais en Histoire de l'Art à l'université." Phd thesis, Université Victor Segalen - Bordeaux II, 2001. http://tel.archives-ouvertes.fr/tel-00007305.

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Cette thèse relate une recherche-action en didactique de l'anglais de spécialité en lien avec les environnements d'apprentissage multimédias. Le versant “recherche” fait appel aux disciplines connexes de la philosophie de l'éducation, de la psychologie de l'apprentissage, de la linguistique appliquée et des sciences cognitives pour forger des outils théoriques. Nous revisitons les modèles ternaires de la situation pédagogique, d'abord pour y redéfinir la place du processus d'enseignement puis pour y introduire les instruments d'enseignement, ce qui nous amène à proposer un modèle nouveau, le c
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Bersten, David Christopher. "Regulation of expression and activity of the bHLH-PAS transcription factor NPAS4." Thesis, 2014. http://hdl.handle.net/2440/96833.

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Development of the Central Nervous System (CNS) relies on complex transcriptional programs to specify distinct neuronal areas/cell types, and guide the formation of neuronal networks. Synaptic activity during post-natal brain development dictates the number and strength of synapses as well as promoting neuronal cell survival through activation of transcriptional programs. The establishment of synapses during this “critical period” of post-natal neuronal development and the local rearrangement, fine tuning and maintenance of synaptic connections into adulthood contributes to synaptic plasticity
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Bergeron, Mario. "Homme-pelle-rideau ou Le reflet du système de micro-informatique dans l'œuvre artistique /." 1996. http://proquest.umi.com/pqdweb?did=738269761&sid=2&Fmt=2&clientId=9268&RQT=309&VName=PQD.

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Winstall, Eric. "Étude des mécanismes de dégradation rapide des ARN messagers modulée par l'élément déstabilisateur riche en AU /." 1997. http://proquest.umi.com/pqdweb?did=736973851&sid=7&Fmt=2&clientId=9268&RQT=309&VName=PQD.

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Books on the topic "Per Arnt Sim (PAS)"

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Svetlana, Khaenko, ed. Metal in art =: Metāls mākslā : Precious metals = Dārgmetāli : Manuel [sic] ode = Oda par metālu : Metal in interior = Metāls interjērā. "Spriditis", 1991.

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Suzor, L. T. Maximes, conseils et instructinos [sic] sur l'état de la guerre, ou, Aide-mémoire pratique de la guerre, à l'usage des militaires de toutes armes et de tous pays: D'après un manuscrit rédigé en 1815 par un général d'alors, et revu en 1855, pour être mis en harmonie avec les connaissances et l'organisation du jour. C. Darveau, 1987.

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Gombert, Florence. Le Maître au Feuillage brodé: Démarches d'artistes et méthodes d'attribution d'œuvres à un peintre anonyme des anciens Pays-Bas du XVe siécle : colloque organisé par le Palais des Beaux-Arts de Lille les 23 et 24 juin 2005 = The Master of the Embroidered Foliage : artists' processes and attribution methods to an anonymus [sic] flemish painter of the XVth century : symposium organised by le Palais des Beaux-Arts de Lille les 23 et 24 juin 2005. Librairie des Musées, 2007.

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Balestero, Gabriela Soares, and Ana Silvia Marcatto Begalli. Estudos de Direito Latino Americano. 11th ed. Editora Amplla, 2022. http://dx.doi.org/10.51859/amplla.edl1037-0.

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Com muita satisfação publicamos mais uma edição da coletânea “Estudos de Direito Latino Americano” em seu Volume XI. Trata-se de uma obra que visa reunir pesquisas sobre diversas temáticas jurídicas tanto do Brasil quanto da América Latina. O primeiro capítulo intitulado “Políticas Públicas e Desigualdade Social nas cidades brasileiras: uma resenha crítica” foi fazer uma resenha crítica do artigo intitulado: Globalização e desafios urbanos: políticas públicas e desigualdade social nas cidades brasileiras, publicado na Revista Eure (Santiago), no ano de 2011. O artigo foi realizado através de u
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Book chapters on the topic "Per Arnt Sim (PAS)"

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Watson, Eve. "Afterword." In Clinical Encounters in Sexuality. punctum books, 2017. https://doi.org/10.21983/p3.0167.1.31.

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Clinical Encounters in Sexuality brings together two altogether different disciplines that address the field of human sexual-ity: clinical psychoanalysis and queer theory. This encounter is underpinned by the centrality of sexuality to both disciplines and the crucial nature of psychoanalytic theory to queer the-ory’s theorization of gender and sexuality. Beginning with Sig-mund Freud, psychoanalysis has a long history of turning to other fields such as philosophy, art, literature, linguistics, sci-ence, mathematics, and religion to develop and differentiate its major themes. This collection a
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"PAS Domain (Per-Arnt-Sim)." In Encyclopedia of Genetics, Genomics, Proteomics and Informatics. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_12369.

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Scheuermann, Thomas H., Jinsong Yang, Lei Zhang, Kevin H. Gardner, and Richard K. Bruick. "Hypoxia‐Inducible Factors Per/ARNT/Sim Domains: Structure and Function." In Methods in Enzymology. Elsevier, 2007. http://dx.doi.org/10.1016/s0076-6879(07)35001-5.

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Mayoral Juan Manuel, Vital Damián, Romo Miguel Pedro, Marengo Humberto, and Díaz Barriga Amós Francisco. "Algunos criterios a considerar en el diseño de presas de hardfill." In From Fundamentals to Applications in Geotechnics. IOS Press, 2015. https://doi.org/10.3233/978-1-61499-603-3-2561.

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Las presas de hardfill son construidas con materiales obtenidos del lecho del río, o del producto de la misma excavación, aglutinados artificialmente con un cementante. En los últimos años las presas de hardfill han tenido un auge a nivel mundial en gran parte debido a su bajo costo, sencilla construcción, y buen comportamiento ante carga sostenida y sísmica. Usualmente se diseñan con una sección simétrica trapecial, de esta forma las cargas transmitidas al terreno de cimentación se re
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Kouamé, Atchêlô Christelle. "Poésie orale et urbanité : essai d’analyses poétique et stylistique d’un slam empreint de nouchi." In Les parlers urbains africains au prisme du plurilinguisme : description sociolinguistique. Observatoire européen du plurilinguisme, 2020. http://dx.doi.org/10.3917/oep.kosso.2020.01.0147.

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Parmi les différents genres littéraires, la poésie bénéficie d’une certaine sacralisation. Elle semble complexe et moins accessible. Elle est abordée avec tant de gravité que, très souvent, le public semble s’en détourner à l’avantage des autres genres. Aujourd’hui, les nouvelles formes de poésie orale, à l’instar du slam, contribuent à populariser cet art verbal longtemps confiné dans les carcans intellectuels. N&#2
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Pimenta, Érika Alice Lopes Vieira, João Paulo da Silva Andrade, and Fernando Soares de Almeida. "A FORMAÇÃO DOCENTE COMO ESTRATÉGIA DE MUDANÇA E MELHORIA." In Educação Contemporânea. Alkarvalho, 2024. http://dx.doi.org/10.29327/5400879.1-1.

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RESUMO Percebemos que a escola brasileira sofreu profundas alterações nos últimos anos. Ela passou de uma organização de certezas para um mundo de incertezas. Estão sendo questionados os fundamentos da instituição escolar: a sua missão, o que ensinar, a quem ensinar, como ensinar, quem é o professor, quem é o aluno. A Formação Continuada dos professores é uma das ações sugeridas pelas políticas educacionais para a melhoria da qualidade educacional. Torna-se cada vez mais claro que, para encontrar seu rumo, a edu?cação brasileira precisa resgatar o professor. Partindo de uma visão estratégica d
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Conference papers on the topic "Per Arnt Sim (PAS)"

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HARIDAS, ASWIN, PAUL D. OKULOV, STEFAN NEUMANN, and HOLGER SPECKMANN. "AN AUTONOMOUS EARLY WARNING SYSTEM CONCEPT FOR REAL-TIME REMOTE MONITORING OF CRITICAL STRUCTURES." In Structural Health Monitoring 2023. Destech Publications, Inc., 2023. http://dx.doi.org/10.12783/shm2023/36921.

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Over the years, Structural Health Monitoring (SHM) and related concepts that focus on monitoring & managing the health of critical structures have gained vast popularity, especially considering the rapid growth and implementation of industry 4.0 approaches in the industrial manufacturing, production and operational environments. However, the implementation of SHM, which is clearly defined by the industry pain-points, have not risen on-par with the expectations of the end users. We believe that this gap could be associated with the following key points, a. the challenges in collecting, hand
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Reports on the topic "Per Arnt Sim (PAS)"

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Lemiere, Catherine, Diane Lougheed, Teresa To, Lucie Blais, and Brian White-Guay. Validation du questionnaire pour le dépistage de l'asthme relié au travail (QDART(L)TM) pour l'amélioration de sa détection précoce. IRSST, 2024. http://dx.doi.org/10.70010/hkig4795.

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L’asthme est une maladie qui touche environ 9 % de la population canadienne. Vingt pour cent des cas d’asthme sont aggravés par l’environnement de travail. On appelle cette condition l’asthme relié au travail (ART). Cependant, les cas d’ART sont souvent sous-diagnostiqués. Le diagnostic d’ART repose fréquemment sur la mise en évidence de l’aggravation des symptômes d’asthme en milieu de travail, cependant un diagnostic objectif d’ART repose sur la mise en évidence de changement de la fonction respiratoire durant les périodes en milieu de travail par rapport à des périodes hors travail. Nous av
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Lundström, Karl, Monica Mion, Maria Ovegård, Malin Karlsson, Flavia Lavinia Gandolfo, and Håkan Wennhage. Storskarv i Sverige : predations- och födosöksstudier. Department of Aquatic Resources, Swedish University of Agricultural Science, 2025. https://doi.org/10.54612/a.2kik7pfeav.

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Efter att tidigare varit utrotad har storskarv (Phalacrocorax carbo) häckat i Sverige sedan mitten av 1900-talet. De flesta storskarvar anländer till Sverige på våren inför häckningssäsongen. Kolonier med häckande storskarvar finns i samtliga län längs kusten men med stora skillnader i antalet häckande par mellan olika geografiska områden. Efter avslutad häckning sprider skarvarna ut sig och flyttar till andra områden. Under hösten lämnar de flesta storskarvarna landet och spenderar en stor del av vinterhalvåret i Europa. Antalet storskarvar som stannar kvar och övervintrar i Sverige varierar
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Berg, Charlotte, Rie Henriksen, Anders Herlin, et al. Hållande av vaktel. SLU:s vetenskapliga råd för djurskydd, 2023. http://dx.doi.org/10.54612/a.3hlcu79vvb.

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Uppdraget har varit att utifrån givna frågeställningar beskriva det kunskapsläge som finns kring hur vaktlar bör hållas och skötas. Med begreppet ”vaktel” avses rent biologiskt inte en enskild art utan ett antal släkten med totalt ca 80 arter av en typ av små hönsfåglar, men det är den japanska vakteln som har domesticerats och idag främst hålls för livsmedelsproduktion. Den japanska vakteln har hållits i fångenskap sedan 1100-talet. Systematisk domesticering och selektion för ägg- respektive köttproduktion har skett mer intensivt sedan omkring förra sekelskiftet, det vill säga i drygt 100 år.
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