Academic literature on the topic 'Perfusable'

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Journal articles on the topic "Perfusable"

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Forgacs, Gabor. "Perfusable vascular networks." Nature Materials 11, no. 9 (2012): 746–47. http://dx.doi.org/10.1038/nmat3412.

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Tian, Ye, and Liqiu Wang. "Microfiber-Patterned Versatile Perfusable Vascular Networks." Micromachines 14, no. 12 (2023): 2201. http://dx.doi.org/10.3390/mi14122201.

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Rapid construction of versatile perfusable vascular networks in vitro with cylindrical channels still remains challenging. Here, a microfiber-patterned method is developed to precisely fabricate versatile well-controlled perfusable vascular networks with cylindrical channels. This method uses tensile microfibers as an easy-removable template to rapidly generate cylindrical-channel chips with one-dimensional, two-dimensional, three-dimensional and multilayered structures, enabling the independent and precise control over the vascular geometry. These perfusable and cytocompatible chips have grea
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Fong, EL, M. Santoro, MC Farach-Carson, FK Kasper, and AG Mikos. "Tissue engineering perfusable cancer models." Current Opinion in Chemical Engineering 3 (February 2014): 112–17. http://dx.doi.org/10.1016/j.coche.2013.12.008.

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Tran, Reginald, Byungwook Ahn, David R. Myers, et al. "Simplified prototyping of perfusable polystyrene microfluidics." Biomicrofluidics 8, no. 4 (2014): 046501. http://dx.doi.org/10.1063/1.4892035.

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Bogorad, Max I., Jackson DeStefano, Johan Karlsson, Andrew D. Wong, Sharon Gerecht, and Peter C. Searson. "Review: in vitro microvessel models." Lab on a Chip 15, no. 22 (2015): 4242–55. http://dx.doi.org/10.1039/c5lc00832h.

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Liu, Juan, Huaiyuan Zheng, Patrina Poh, Hans-Günther Machens, and Arndt Schilling. "Hydrogels for Engineering of Perfusable Vascular Networks." International Journal of Molecular Sciences 16, no. 7 (2015): 15997–6016. http://dx.doi.org/10.3390/ijms160715997.

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Štumberger, Gabriela, and Boštjan Vihar. "Freeform Perfusable Microfluidics Embedded in Hydrogel Matrices." Materials 11, no. 12 (2018): 2529. http://dx.doi.org/10.3390/ma11122529.

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We report a modification of the freeform reversible embedding of suspended hydrogels (FRESH) 3D printing method for the fabrication of freeform perfusable microfluidics inside a hydrogel matrix. Xanthan gum is deposited into a CaCl2 infused gelatine slurry to form filaments, which are consequently rinsed to produce hollow channels. This provides a simple method for rapid prototyping of microfluidic devices based on biopolymers and potentially a new approach to the construction of vascular grafts for tissue engineering.
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He, Jiankang, Lin Zhu, Yaxiong Liu, Dichen Li, and Zhongmin Jin. "Sequential assembly of 3D perfusable microfluidic hydrogels." Journal of Materials Science: Materials in Medicine 25, no. 11 (2014): 2491–500. http://dx.doi.org/10.1007/s10856-014-5270-9.

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Xu, Peidi, Ruoxiao Xie, Yupeng Liu, Guoan Luo, Mingyu Ding, and Qionglin Liang. "Bioinspired Microfibers with Embedded Perfusable Helical Channels." Advanced Materials 29, no. 34 (2017): 1701664. http://dx.doi.org/10.1002/adma.201701664.

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Skylar-Scott, Mark A., Sebastien G. M. Uzel, Lucy L. Nam, et al. "Biomanufacturing of organ-specific tissues with high cellular density and embedded vascular channels." Science Advances 5, no. 9 (2019): eaaw2459. http://dx.doi.org/10.1126/sciadv.aaw2459.

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Engineering organ-specific tissues for therapeutic applications is a grand challenge, requiring the fabrication and maintenance of densely cellular constructs composed of ~108 cells/ml. Organ building blocks (OBBs) composed of patient-specific–induced pluripotent stem cell–derived organoids offer a pathway to achieving tissues with the requisite cellular density, microarchitecture, and function. However, to date, scant attention has been devoted to their assembly into 3D tissue constructs. Here, we report a biomanufacturing method for assembling hundreds of thousands of these OBBs into living
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Dissertations / Theses on the topic "Perfusable"

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Whisler, Jordan Ari. "Engineered, functional, human microvasculature in a perfusable fluidic device." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/113761.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2017.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 141-154).<br>Engineered, human tissue models will enable us to study disease more accurately, and develop treatments more economically, than ever before. Functional tissue grown in the laboratory will also provide a much-needed source for the clinical replacement of diseased or damaged tissues. A major hindrance to the development of these technologies has been the inability to vascularize tissue-engineered con
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Whisler, Jordan Ari. "Engineered, perfusable, human microvascular networks on a microfluidic chip." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/85772.

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Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2013.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 61-64).<br>In this thesis, we developed a reliable platform for engineering perfusable, microvascular networks on-demand using state of the art microfluidics technology. We have demonstrated the utility of this platform for studying cancer metastasis and as a test bed for drug discovery and analysis. In parallel, this platform enabled us to study, in a highly controlled environment, the physiologic processes of a
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Sphabmixay, Pierre. "Engineering micro-perfusable scaffolds for MesoPhysiological Systems using projection Micro-StereoLithography." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/129115.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2020<br>Cataloged from student-submitted PDF of thesis.<br>Includes bibliographical references (pages 140-155).<br>MicroPhysiological Systems (MPS) are in vitro models that capture the complexity of human organs at miniature scale by recreating the native microenvironment of resident cells. These systems offer promising alternatives to in vivo animal models for the development of new drugs, disease modeling and biological research. The organs in the human body are continuously perfused via a dense netw
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Salameh, Sacha. "A perfusable vascularized full thickness skin model for topical and systemic applications." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS466.

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De nombreux progrès ont déjà été réalisés pour développer des modèles de peau in vitro plus complexes et s’approchant de plus en plus du tissu in vivo. Cependant, la vascularisation reste l’un des défis à relever pour l’évolution des peaux reconstruites. Notre étude s'est concentrée sur le développement d'un équivalent de peau complète vascularisée et perfusée avec un réseau vasculaire plus complexe que les modèles déjà existants. Ainsi, nous avons combiné trois techniques : le moulage de la matrice, l’auto-assemblage des cellules endothéliales et la microfluidique. Ainsi, nous avons créé un é
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Entz, Michael William II. "Effects of Perfusate Solution Composition on the Relationship between Cardiac Conduction Velocity and Gap Junction Coupling." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/81823.

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Reproducibility of results in biomedical research is an area of concern that should be paramount for all researchers. Importantly, this issue has been examined for experiments concerning cardiac electrophysiology. Specifically, multiple labs have found differences in results when comparing cardiac conduction velocity (CV) between healthy mice and mice that were heterozygous null for the gap junction (GJ) forming protein, Connexin 43. While the results of the comparison study showed differing extracellular ionic concentrations of the perfusates, specifically sodium, potassium, and calcium ([Na+
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Webster, Kelly Eileen. "Quantifying Renal Swelling during Machine Perfusion using Digital Image Correlation." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/78244.

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While machine perfusion of explanted kidneys is theoretically superior to standard cold storage, it may damage potential transplants unless machine-associated swelling is controlled. This thesis presents the effects of perfusate tonicity on renal swelling during hypothermic machine perfusion. Phosphate buffered solution (PBS) and PBS supplemented with 5% w/v mannitol were used as isotonic (289 mOsm/kg) and hypertonic (568 mOsm/kg) perfusates, respectively. Porcine kidney pairs were procured then flushed and machine perfused; the right and left kidneys were assigned opposite perfusates. An e
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Street, Darrin. "Skeletal muscle interstitium and blood pH at rest and during exercise in humans." Thesis, Queensland University of Technology, 2003. https://eprints.qut.edu.au/15850/1/Darrin_Street_Thesis.pdf.

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The aims of this thesis were to: 1) develop a new method for the determination of interstitial pH at rest and during exercise in vivo, 2) systematically explore the effects of different ingestion regimes of 300 mg.kg-1 sodium citrate on blood and urine pH at rest, and 3) to combine the new interstitial pH technique with the findings of the second investigation in an attempt to provide a greater understanding of H+ movement between the extracellular compartments. The purpose of the first study was to develop a method for the continuous measurement of interstitial pH in vastus lateralis was s
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Street, Darrin. "Skeletal Muscle Interstitium and Blood pH at Rest and During Exercise in Humans." Queensland University of Technology, 2003. http://eprints.qut.edu.au/15850/.

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The aims of this thesis were to: 1) develop a new method for the determination of interstitial pH at rest and during exercise in vivo, 2) systematically explore the effects of different ingestion regimes of 300 mg.kg-1 sodium citrate on blood and urine pH at rest, and 3) to combine the new interstitial pH technique with the findings of the second investigation in an attempt to provide a greater understanding of H+ movement between the extracellular compartments. The purpose of the first study was to develop a method for the continuous measurement of interstitial pH in vastus lateralis was suc
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Bhowmik, Swati. "Development of analytical methods for the gas chromatographic determination of 1,2-epoxy-3-butene, 1,2:3,4-diepoxybutane, 3-butene-1,2-diol, 3,4-epoxybutane-1,2-diol and crotonaldehyde from perfusate samples of 1,3-butadiene exposed isolated mouse and rat livers." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=967431743.

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Weinreb, Ross H. "Fabrication of a tissue- engineered perfusable skin flap." Thesis, 2016. https://hdl.handle.net/2144/16753.

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To date, the reconstructive approach addressing chronic non-healing wounds, deep tissue damage, and severe wound defects relies upon avascular dermal grafts and autologous flap techniques. Such flaps are limited by donor site availability and morbidity, while current dermal grafts rely upon host cellular invasion for neovascularization and incorporation. These products fail to include an inherent vascular network and the supporting cells necessary to ensure adequate incorporation and graft survival beyond the most optimal wound beds. Herein, we fabricate a pre-vascularized full-thickness cellu
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Book chapters on the topic "Perfusable"

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Maharjan, Sushila, Jacqueline Jialu He, Li Lv, Di Wang, and Yu Shrike Zhang. "Microfluidic Coaxial Bioprinting of Hollow, Standalone, and Perfusable Vascular Conduits." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1708-3_6.

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Lapin, Brice, Sarah Myram, Manh-Louis Nguyen, Giacomo Gropplero, Sylvie Coscoy, and Stéphanie Descroix. "Construction of a Multitubular Perfusable Kidney-on-Chip for the Study of Renal Diseases." In Methods in Molecular Biology. Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-3179-9_7.

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Tobe, Yusuke, Katsuhisa Sakaguchi, Jun Homma, et al. "Reconstruction of a Vascular Bed with Perfusable Blood Vessels Using a Decellularized Porcine Small Intestine for Clinical Application." In IFMBE Proceedings. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-66169-4_35.

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Pigot, Henry, Kristian Soltesz, and Stig Steen. "Ex Vivo Working Porcine Heart Model." In Methods in Molecular Biology. Springer US, 2024. http://dx.doi.org/10.1007/978-1-0716-3846-0_7.

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AbstractEx vivo working porcine heart models allow for the study of a heart’s function and physiology outside the living organism. These models are particularly useful due to the anatomical and physiological similarities between porcine and human hearts, providing an experimental platform to investigate cardiac disease or assess donor heart viability for transplantation. This chapter presents an in-depth discussion of the model’s components, including the perfusate, preload, and afterload. We explore the challenges of emulating cardiac afterload and present a historical perspective on afterloa
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Gronow, Gemot, and Herbert Kossmann. "Perfusate Oxygenation and Renal Function in the Isolated Rat Kidney." In Advances in Experimental Medicine and Biology. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-3291-6_68.

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Miyajima, Masakazu, Kazuaki Shimoji, Misuya Watanabe, Madoka Nakajima, Ikuko Ogino, and Hajime Arai. "Role of Artificial Cerebrospinal Fluid as Perfusate in Neuroendoscopic Surgery: A Basic Investigation." In Acta Neurochirurgica Supplementum. Springer Vienna, 2011. http://dx.doi.org/10.1007/978-3-7091-0923-6_21.

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Ogihara, Tohru, Therese Dupin, Haruyuki Nakane, et al. "Metabolism of Bradykinin in Isolated Perfused Rat Kidney Measurement of Kininase Activity in Perfusate and Urine." In Kinins IV. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5143-6_50.

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Funahara, Yoshinori, Michiko Miki, Mari Hirata, Koji Ogawa, and Hiromichi Kitaguchi. "Increase in Factor VIII Clotting Activity in the Perfusate of Isolated Dog Hind Leg and Heart by Components of Kallikrein-Kinin System." In Kinins IV. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4757-0154-8_10.

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Lange, R., J. Erhard, U. Rauen, A. Hellinger, H. de Groot, and F. W. Eigler. "Injury to hepatocytes and non-parenchymal cells during the preservation of human livers with UW or HTK solution: a determination of hepatocellular enzymes in the effluent perfusate for preoperative evaluation of the transplant quality." In Transplant International. Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-662-00818-8_113.

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Tomov, Martin L., Alex D. Cetnar, Andrea S. Theus, et al. "3D Bioprinted Perfusable Tissue Constructs." In Emerging Technologies in Biophysical Sciences: A World Scientific Reference. WORLD SCIENTIFIC, 2022. http://dx.doi.org/10.1142/9789811226090_0009.

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Conference papers on the topic "Perfusable"

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Croce, Júlia Nonato, Juliana Cristina Barreiro, Jose D. Vollet-Filho, Loraine C. Goenaga Mafud, and Cristina Kurachi. "Investigating Photosensitizing Properties of Methylene Blue on Perfusate Solutions Decontamination for Organ Preservation." In 2024 SBFoton International Optics and Photonics Conference (SBFoton IOPC). IEEE, 2024. https://doi.org/10.1109/sbfotoniopc62248.2024.10813527.

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Mori, Nobuhito, Yuya Morimoto, and Shoji Takeuchi. "Skin-equivalent integrated with perfusable channels on curved surface." In 2015 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2015. http://dx.doi.org/10.1109/memsys.2015.7050961.

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Suzuki, Ryosuke, Yuya Morimoto, Ai Shima, and Shoji Takeuchi. "Stretchable and Perfusable Microfluidic Device for Cell Barrier Model." In 2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2020. http://dx.doi.org/10.1109/mems46641.2020.9056239.

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Cook, Colin A., Yang Liu, Jianming Lu, Nanhai Chen, Yuman Fong, and Yu-Chong Tai. "Gas perfusable microfabricated membranes for high-density cell culture." In 2017 IEEE 30th International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2017. http://dx.doi.org/10.1109/memsys.2017.7863445.

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Sawayama, Jun, Fumisato Ozawa, and Shoji Takeuchi. "Continuous Glucose Monitoring of 3D Tissue Using a Perfusable Device." In 2019 IEEE 32nd International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2019. http://dx.doi.org/10.1109/memsys.2019.8870795.

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Osaki, Tatsuya, Takahiro Kakegawa, Naoto Mochizuki, and Junji Fukuda. "Fabrication of perfusable vasculatures by using micromolding and electrochemical cell transfer." In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2013. http://dx.doi.org/10.1109/embc.2013.6611082.

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Ishii, Yasuaki, Yuya Morimoto, Ai Shima, and Shoji Takeuchi. "Formation of Micro-Size Perfusable Channels in mm-Thick Muscle Tissue." In 2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2020. http://dx.doi.org/10.1109/mems46641.2020.9056142.

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Wang, Junfeng, Byungjun Lee, Tsung-Li Liu, et al. "1414 Engineering a perfusable vascularized tumor immune microenvironment using microphysiological system." In SITC 39th Annual Meeting (SITC 2024) Abstracts. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/jitc-2024-sitc2024.1414.

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Bircsak, K. M., V. van Duinen, S. J. Trietsch, et al. "Abstract 2051: Perfusable 3D angiogenesis in a high-throughput microfluidic culture platform." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-2051.

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Cui, Juan, Huaping Wang, Qing Shi, et al. "Microrobotic assembly of shape-controllable microstructures to perfusable 3D cell-laden microtissues." In 2017 IEEE 7th Annual International Conference on CYBER Technology in Automation, Control, and Intelligent Systems (CYBER). IEEE, 2017. http://dx.doi.org/10.1109/cyber.2017.8446611.

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Reports on the topic "Perfusable"

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Martinez, Melissa. Visual Patching and Imaging Chambers. ConductScience, 2022. http://dx.doi.org/10.55157/cs20220507.

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Specimens obtained from brain slicing experiments, cell research, and skin studies are sensitive to temperature variations, humidity, and air quality. Proper temperature control is crucial to prevent cell distortion and necrosis, ensuring accurate observations and data collection. A visual patching and imaging chamber is introduced as a vital tool for maintaining optimal specimen temperature in behavioral, neuroimaging, and electrophysiological studies. The chamber features an aluminum heat exchanger plate with precise temperature control, gas inlet, and perfusate tubes. It's used in rodent re
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