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Journal articles on the topic 'Perfusable'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Forgacs, Gabor. "Perfusable vascular networks." Nature Materials 11, no. 9 (2012): 746–47. http://dx.doi.org/10.1038/nmat3412.

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2

Tian, Ye, and Liqiu Wang. "Microfiber-Patterned Versatile Perfusable Vascular Networks." Micromachines 14, no. 12 (2023): 2201. http://dx.doi.org/10.3390/mi14122201.

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Rapid construction of versatile perfusable vascular networks in vitro with cylindrical channels still remains challenging. Here, a microfiber-patterned method is developed to precisely fabricate versatile well-controlled perfusable vascular networks with cylindrical channels. This method uses tensile microfibers as an easy-removable template to rapidly generate cylindrical-channel chips with one-dimensional, two-dimensional, three-dimensional and multilayered structures, enabling the independent and precise control over the vascular geometry. These perfusable and cytocompatible chips have grea
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3

Fong, EL, M. Santoro, MC Farach-Carson, FK Kasper, and AG Mikos. "Tissue engineering perfusable cancer models." Current Opinion in Chemical Engineering 3 (February 2014): 112–17. http://dx.doi.org/10.1016/j.coche.2013.12.008.

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4

Tran, Reginald, Byungwook Ahn, David R. Myers, et al. "Simplified prototyping of perfusable polystyrene microfluidics." Biomicrofluidics 8, no. 4 (2014): 046501. http://dx.doi.org/10.1063/1.4892035.

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5

Bogorad, Max I., Jackson DeStefano, Johan Karlsson, Andrew D. Wong, Sharon Gerecht, and Peter C. Searson. "Review: in vitro microvessel models." Lab on a Chip 15, no. 22 (2015): 4242–55. http://dx.doi.org/10.1039/c5lc00832h.

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6

Liu, Juan, Huaiyuan Zheng, Patrina Poh, Hans-Günther Machens, and Arndt Schilling. "Hydrogels for Engineering of Perfusable Vascular Networks." International Journal of Molecular Sciences 16, no. 7 (2015): 15997–6016. http://dx.doi.org/10.3390/ijms160715997.

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7

Štumberger, Gabriela, and Boštjan Vihar. "Freeform Perfusable Microfluidics Embedded in Hydrogel Matrices." Materials 11, no. 12 (2018): 2529. http://dx.doi.org/10.3390/ma11122529.

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We report a modification of the freeform reversible embedding of suspended hydrogels (FRESH) 3D printing method for the fabrication of freeform perfusable microfluidics inside a hydrogel matrix. Xanthan gum is deposited into a CaCl2 infused gelatine slurry to form filaments, which are consequently rinsed to produce hollow channels. This provides a simple method for rapid prototyping of microfluidic devices based on biopolymers and potentially a new approach to the construction of vascular grafts for tissue engineering.
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8

He, Jiankang, Lin Zhu, Yaxiong Liu, Dichen Li, and Zhongmin Jin. "Sequential assembly of 3D perfusable microfluidic hydrogels." Journal of Materials Science: Materials in Medicine 25, no. 11 (2014): 2491–500. http://dx.doi.org/10.1007/s10856-014-5270-9.

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9

Xu, Peidi, Ruoxiao Xie, Yupeng Liu, Guoan Luo, Mingyu Ding, and Qionglin Liang. "Bioinspired Microfibers with Embedded Perfusable Helical Channels." Advanced Materials 29, no. 34 (2017): 1701664. http://dx.doi.org/10.1002/adma.201701664.

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10

Skylar-Scott, Mark A., Sebastien G. M. Uzel, Lucy L. Nam, et al. "Biomanufacturing of organ-specific tissues with high cellular density and embedded vascular channels." Science Advances 5, no. 9 (2019): eaaw2459. http://dx.doi.org/10.1126/sciadv.aaw2459.

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Engineering organ-specific tissues for therapeutic applications is a grand challenge, requiring the fabrication and maintenance of densely cellular constructs composed of ~108 cells/ml. Organ building blocks (OBBs) composed of patient-specific–induced pluripotent stem cell–derived organoids offer a pathway to achieving tissues with the requisite cellular density, microarchitecture, and function. However, to date, scant attention has been devoted to their assembly into 3D tissue constructs. Here, we report a biomanufacturing method for assembling hundreds of thousands of these OBBs into living
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11

Zhang, Yahui, Yin Yu, Adil Akkouch, Amer Dababneh, Farzaneh Dolati, and Ibrahim T. Ozbolat. "In vitro study of directly bioprinted perfusable vasculature conduits." Biomaterials Science 3, no. 1 (2015): 134–43. http://dx.doi.org/10.1039/c4bm00234b.

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12

Lei, Dong, Yang Yang, Zenghe Liu, et al. "3D printing of biomimetic vasculature for tissue regeneration." Materials Horizons 6, no. 6 (2019): 1197–206. http://dx.doi.org/10.1039/c9mh00174c.

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13

Liu, Yupeng, Peidi Xu, Zhe Liang, et al. "Hydrogel microfibers with perfusable folded channels for tissue constructs with folded morphology." RSC Advances 8, no. 42 (2018): 23475–80. http://dx.doi.org/10.1039/c8ra04192j.

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14

Piccone, Ashley. "Creating perfusable channels in tissue with embedded printing." Scilight 2022, no. 3 (2022): 031108. http://dx.doi.org/10.1063/10.0009389.

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15

Menon, Nishanth Venugopal, Hui Min Tay, Soon Nan Wee, King Ho Holden Li, and Han Wei Hou. "Micro-engineered perfusable 3D vasculatures for cardiovascular diseases." Lab on a Chip 17, no. 17 (2017): 2960–68. http://dx.doi.org/10.1039/c7lc00607a.

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16

Liu, Zhou, Yuyan Zhang, Tiyun Yang, et al. "Soft ionic devices by perfusable all-hydrogel microfluidics." Journal of Materials Chemistry C 8, no. 7 (2020): 2320–25. http://dx.doi.org/10.1039/c9tc05639d.

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17

Gui, Liqiong, and Laura E. Niklason. "Vascular tissue engineering: building perfusable vasculature for implantation." Current Opinion in Chemical Engineering 3 (February 2014): 68–74. http://dx.doi.org/10.1016/j.coche.2013.11.004.

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18

Campbell, Rachel, Karina A. Hernandez, Tatiana Boyko, et al. "Fabrication of perfusable microvessels within tissue engineered constructs." Journal of the American College of Surgeons 217, no. 3 (2013): S143—S144. http://dx.doi.org/10.1016/j.jamcollsurg.2013.07.337.

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19

Han, Li-Hsin. "Fabricating a new heart: One step closer to reality." Science Translational Medicine 11, no. 490 (2019): eaax4870. http://dx.doi.org/10.1126/scitranslmed.aax4870.

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20

Xiao, Yun, Boyang Zhang, Haijiao Liu, et al. "Microfabricated perfusable cardiac biowire: a platform that mimics native cardiac bundle." Lab Chip 14, no. 5 (2014): 869–82. http://dx.doi.org/10.1039/c3lc51123e.

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21

Ortega, Ilida, Lindsey Dew, Adam G. Kelly, Chuh K. Chong, Sheila MacNeil, and Frederik Claeyssens. "Fabrication of biodegradable synthetic perfusable vascular networks via a combination of electrospinning and robocasting." Biomaterials Science 3, no. 4 (2015): 592–96. http://dx.doi.org/10.1039/c4bm00418c.

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22

Tao, Tingting, Yaqing Wang, Wenwen Chen, et al. "Engineering human islet organoids from iPSCs using an organ-on-chip platform." Lab on a Chip 19, no. 6 (2019): 948–58. http://dx.doi.org/10.1039/c8lc01298a.

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23

Liu, Yupeng, Peidi Xu, Zhe Liang, et al. "Correction: Hydrogel microfibers with perfusable folded channels for tissue constructs with folded morphology." RSC Advances 9, no. 19 (2019): 10625. http://dx.doi.org/10.1039/c9ra90025j.

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24

Shimizu, Azusa, Wei Huang Goh, Shun Itai, Michinao Hashimoto, Shigenori Miura, and Hiroaki Onoe. "ECM-based microchannel for culturing in vitro vascular tissues with simultaneous perfusion and stretch." Lab on a Chip 20, no. 11 (2020): 1917–27. http://dx.doi.org/10.1039/d0lc00254b.

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25

Hong, Soyoung, Yejin Song, Jaesoon Choi, and Changmo Hwang. "Bonding of Flexible Membranes for Perfusable Vascularized Networks Patch." Tissue Engineering and Regenerative Medicine 19, no. 2 (2021): 363–75. http://dx.doi.org/10.1007/s13770-021-00409-1.

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Abstract BACKGROUND: In vitro generation of three-dimensional vessel network is crucial to investigate and possibly improve vascularization after implantation in vivo. This work has the purpose of engineering complex tissue regeneration of a vascular network including multiple cell-type, an extracellular matrix, and perfusability for clinical application. METHODS: The two electrospun membranes bonded with the vascular network shape are cultured with endothelial cells and medium flow through the engineered vascular network. The flexible membranes are bonded by amine-epoxy reaction and examined
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26

Chiu, L. L. Y., M. Montgomery, Y. Liang, H. Liu, and M. Radisic. "Perfusable branching microvessel bed for vascularization of engineered tissues." Proceedings of the National Academy of Sciences 109, no. 50 (2012): E3414—E3423. http://dx.doi.org/10.1073/pnas.1210580109.

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27

Mansbridge, J., B. Maguire, and N. Bursacs. "PERFUSABLE SCAFFOLD FOR THE FORMATION OF VASCULARIZED SOLID ORGANS." ASAIO Journal 47, no. 2 (2001): 134. http://dx.doi.org/10.1097/00002480-200103000-00133.

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28

Mori, Nobuhito, Yuya Morimoto, and Shoji Takeuchi. "Perfusable and stretchable 3D culture system for skin-equivalent." Biofabrication 11, no. 1 (2018): 011001. http://dx.doi.org/10.1088/1758-5090/aaed12.

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29

Knaapen, P. "The perfusable tissue index: a marker of myocardial viability." Journal of Nuclear Cardiology 10, no. 6 (2003): 684–91. http://dx.doi.org/10.1016/s1071-3581(03)00656-1.

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30

Mori, Nobuhito, Yuya Morimoto, and Shoji Takeuchi. "Skin integrated with perfusable vascular channels on a chip." Biomaterials 116 (February 2017): 48–56. http://dx.doi.org/10.1016/j.biomaterials.2016.11.031.

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31

Hooper, Rachel Campbell, Adam Jacoby, Ope A. Asanbe, Hector L. Osoria, Tarek Elshazly, and Jason A. Spector. "Fabrication of Durable, Perfusable Microvessels within Tissue-Engineered Constructs." Journal of the American College of Surgeons 219, no. 3 (2014): S154. http://dx.doi.org/10.1016/j.jamcollsurg.2014.07.371.

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32

Jung, Olive, Yen-Ting Tung, Esther Sim, et al. "Development of human-derived, three-dimensional respiratory epithelial tissue constructs with perfusable microvasculature on a high-throughput microfluidics screening platform." Biofabrication 14, no. 2 (2022): 025012. http://dx.doi.org/10.1088/1758-5090/ac32a5.

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Abstract The COVID-19 pandemic has highlighted the need for human respiratory tract-based assay platforms for efficient discovery and development of antivirals and disease-modulating therapeutics. Physiologically relevant tissue models of the lower respiratory tract (LRT), including the respiratory bronchioles and the alveolar sacs, are of high interest because they are the primary site of severe SARS-CoV-2 infection and are most affected during the terminal stage of COVID-19. Current epithelial lung models used to study respiratory viral infections include lung epithelial cells at the air–liq
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33

Figueiredo, Lara, Catherine Le Visage, Pierre Weiss, and Jing Yang. "Quantifying Oxygen Levels in 3D Bioprinted Cell-Laden Thick Constructs with Perfusable Microchannel Networks." Polymers 12, no. 6 (2020): 1260. http://dx.doi.org/10.3390/polym12061260.

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The survival and function of thick tissue engineered implanted constructs depends on pre-existing, embedded, functional, vascular-like structures that are able to integrate with the host vasculature. Bioprinting was employed to build perfusable vascular-like networks within thick constructs. However, the improvement of oxygen transportation facilitated by these vascular-like networks was directly quantified. Using an optical fiber oxygen sensor, we measured the oxygen content at different positions within 3D bioprinted constructs with and without perfusable microchannel networks. Perfusion was
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34

Deng, Pengwei, Mengqian Zhao, Xu Zhang, and Jianhua Qin. "A Transwell-Based Vascularized Model to Investigate the Effect of Interstitial Flow on Vasculogenesis." Bioengineering 9, no. 11 (2022): 668. http://dx.doi.org/10.3390/bioengineering9110668.

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Interstitial flow plays a significant role in vascular system development, mainly including angiogenesis and vasculogenesis. However, compared to angiogenesis, the effect of interstitial flow on vasculogenesis is less explored. Current in vitro models for investigating the effect of interstitial flow on vasculogenesis heavily rely on microfluidic chips, which require microfluidic expertise and facilities, and may not be accessible to biological labs. Here, we proposed a facile approach to building perfusable vascular networks through the self-assembly of endothelial cells in a modified transwe
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35

Schepers, Arnout, Cheri Li, Arnav Chhabra, Benjamin Tschudy Seney, and Sangeeta Bhatia. "Engineering a perfusable 3D human liver platform from iPS cells." Lab on a Chip 16, no. 14 (2016): 2644–53. http://dx.doi.org/10.1039/c6lc00598e.

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36

Itai, Shun, Hisatsugu Tajima, and Hiroaki Onoe. "Double-layer perfusable collagen microtube device for heterogeneous cell culture." Biofabrication 11, no. 1 (2018): 015010. http://dx.doi.org/10.1088/1758-5090/aaf09b.

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37

Osaki, Tatsuya, Takahiro Kakegawa, Tatsuto Kageyama, Junko Enomoto, Tadashi Nittami, and Junji Fukuda. "Acceleration of Vascular Sprouting from Fabricated Perfusable Vascular-Like Structures." PLOS ONE 10, no. 4 (2015): e0123735. http://dx.doi.org/10.1371/journal.pone.0123735.

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38

Kim, Sudong, Hyunjae Lee, Minhwan Chung, and Noo Li Jeon. "Engineering of functional, perfusable 3D microvascular networks on a chip." Lab on a Chip 13, no. 8 (2013): 1489. http://dx.doi.org/10.1039/c3lc41320a.

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39

Gershlak, Joshua R., Sarah Hernandez, Gianluca Fontana, et al. "Crossing kingdoms: Using decellularized plants as perfusable tissue engineering scaffolds." Biomaterials 125 (May 2017): 13–22. http://dx.doi.org/10.1016/j.biomaterials.2017.02.011.

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40

Kim, Da-Hyun, Jungho Ahn, Hyun Kyoung Kang, et al. "Development of highly functional bioengineered human liver with perfusable vasculature." Biomaterials 265 (January 2021): 120417. http://dx.doi.org/10.1016/j.biomaterials.2020.120417.

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41

He, Jiankang, Mao Mao, Yaxiong Liu, Jinyou Shao, Zhongmin Jin, and Dichen Li. "Fabrication of Nature-Inspired Microfluidic Network for Perfusable Tissue Constructs." Advanced Healthcare Materials 2, no. 8 (2013): 1108–13. http://dx.doi.org/10.1002/adhm.201200404.

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42

Karp, Sophie, Martin Pollak, and Balaji karthick Subramanian. "Perfusable Human Tubule Chip System to Model Polycystic Kidney Disease." Journal of the American Society of Nephrology 33, no. 11S (2022): 609–10. http://dx.doi.org/10.1681/asn.20223311s1609d.

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43

Gensler, Marius, Christoph Malkmus, Philipp Ockermann, et al. "Perfusable Tissue Bioprinted into a 3D-Printed Tailored Bioreactor System." Bioengineering 11, no. 1 (2024): 68. http://dx.doi.org/10.3390/bioengineering11010068.

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Bioprinting provides a powerful tool for regenerative medicine, as it allows tissue construction with a patient’s specific geometry. However, tissue culture and maturation, commonly supported by dynamic bioreactors, are needed. We designed a workflow that creates an implant-specific bioreactor system, which is easily producible and customizable and supports cell cultivation and tissue maturation. First, a bioreactor was designed and different tissue geometries were simulated regarding shear stress and nutrient distribution to match cell culture requirements. These tissues were then directly bi
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44

Russell, Teal, Qassim Dirar, Yan Li, Chiwan Chiang, Daniel T. Laskowitz, and Yeoheung Yun. "Cortical spheroid on perfusable microvascular network in a microfluidic device." PLOS ONE 18, no. 10 (2023): e0288025. http://dx.doi.org/10.1371/journal.pone.0288025.

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Human induced pluripotent stem cell (hiPSC)-derived brain spheroids can recapitulate the complex cytoarchitecture of the brain, as well as the genetic/epigenetic footprint of human brain development. However, hiPSC-derived 3D models such as spheroid and organoids does not have a perfusable microvascular network, which plays a vital role in maintaining homeostasis in vivo. With the critical balance of positive and negative angiogenic modulators, 3D microvascular network can be achieved by angiogenesis. This paper reports on a microfluidic-based three-dimensional, cortical spheroid grafted on th
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45

Yu, Yanrong, Renjian Xie, Yueteng He, et al. "Dual-core coaxial bioprinting of double-channel constructs with a potential for perfusion and interaction of cells." Biofabrication 14, no. 3 (2022): 035012. http://dx.doi.org/10.1088/1758-5090/ac6e88.

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Abstract Coaxial bioprinting of hydrogel tubes has tremendous potential in the fabrication of highly complex large-scale vascularized structures, however, constructs with bioinks of simultaneous weak printability and perfusable networks have not been reported. Here, we report a coaxial printing method in which double-channel filaments are three-dimensional (3D) extrusion-bioprinted using a customized dual-core coaxial nozzle. The filament in one channel can perform core/shell role and the other channel can play a role in perfusion. These parallel channels within filaments are separated by an i
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46

Bogorad, Max I., and Peter C. Searson. "Real-time imaging and quantitative analysis of doxorubicin transport in a perfusable microvessel platform." Integrative Biology 8, no. 9 (2016): 976–84. http://dx.doi.org/10.1039/c6ib00082g.

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The kinetics of solute transport across cell monolayers is complex, and often consists of multiple active transport processes in addition to passive diffusion. Here we demonstrate that mechanistic details of transport across biological barriers can be obtained from live cell imaging in a perfusable microvessel model with physiologically relevant geometry.
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47

Huang, Shixing, Dong Lei, Qi Yang, et al. "A perfusable, multifunctional epicardial device improves cardiac function and tissue repair." Nature Medicine 27, no. 3 (2021): 480–90. http://dx.doi.org/10.1038/s41591-021-01279-9.

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48

Davoodi, Elham, Hossein Montazerian, Masoud Zhianmanesh, et al. "Template‐Enabled Biofabrication of Thick 3D Tissues with Patterned Perfusable Macrochannels." Advanced Healthcare Materials 11, no. 7 (2022): 2102123. http://dx.doi.org/10.1002/adhm.202102123.

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49

Bichsel, Colette A., Sean R. R. Hall, Ralph A. Schmid, Olivier T. Guenat, and Thomas Geiser. "Primary Human Lung Pericytes Support and Stabilize In Vitro Perfusable Microvessels." Tissue Engineering Part A 21, no. 15-16 (2015): 2166–76. http://dx.doi.org/10.1089/ten.tea.2014.0545.

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50

Qu, Jin, Rose M. Van Hogezand, Chunfeng Zhao, Benjamin J. Kuo, and Brian T. Carlsen. "Decellularization of a Fasciocutaneous Flap for Use as a Perfusable Scaffold." Annals of Plastic Surgery 75, no. 1 (2015): 112–16. http://dx.doi.org/10.1097/sap.0000000000000157.

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