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1

Haddad, Joseph, and Elie Saliba, eds. Perinatal Asphyxia. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77896-4.

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2

Lacoius-Petruccelli, Alberto. Perinatal Asphyxia. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-1807-1.

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3

Perinatal asphyxia. New York: Plenum Medical Book Co., 1986.

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4

Ruth, Vineta. Perinatal asphyxia: Biochemical parameters as indices of asphyxia at birth and predictors of brain damage, and a trial of preventing damage by phenobarbital. Helsinki: University of Helsinki, 1988.

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5

L, Wright Linda, Merenstein Gerald B, Hirtz Deborah, National Institute of Child Health and Human Development (U.S.), National Institute of Neurological Disorders and Stroke (U.S.), American Academy of Pediatrics, and American College of Obstetricians and Gynecologists., eds. Report of the Workshop on Acute Perinatal Asphyxia in Term Infants: August 30-31, 1993, Rockville, Maryland. [Washington, D.C.?]: The Institute, 1996.

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6

Workshop on Acute Perinatal Asphyxia in Term Infants (1993 Rockville, Md.). Report of the Workshop on Acute Perinatal Asphyxia in Term Infants: August 30-31, 1993, Rockville, Maryland. [Washington, D.C.?]: The Institute, 1996.

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7

Symposium on Perinatal Asphyxia (1988 Toronto, Ont.). Perinatal asphyxia: Its role in developmental deficits in children : papers and discussion based on a symposium held October 26, 1988, in Toronto, Ontario, Canada, jointly with the 42nd Annual Meeting of the American Academy for Cerebral Palsy and Developmental Medicine and sponsored by the Canadian Medical Protective Association. Ottawa, Ontario: Canadian Medical Protective Association, 1988.

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8

Lacoius-Petruccelli, Alberto. Perinatal Asphyxia. Vantage Press, 2006.

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9

J, Haddad, Saliba E. 1950-, and Arbeille Ph, eds. Perinatal asphyxia. Berlin: Springer-Verlag, 1993.

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10

Haddad, Joseph, and Elie Saliba. Perinatal Asphyxia. Springer, 2011.

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11

Sabaratnam, Arulkumaran, and Jenkins H. M. L, eds. Perinatal asphyxia. London: Sangam, 2000.

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12

Arulkumaran, S. Perinatal Asphyxia. Orient Longman Limited, 2000.

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13

Perinatal Asphyxia. Springer, 2011.

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14

Perinatal asphyxia. Philadelphia: Saunders, 1993.

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15

(Editor), Sabaratnam Arulkumaran, and H.M.L. Jenkins (Editor), eds. Perinatal Asphyxia (Obstetrics & Gynecology in Perspective). Sangam Books Ltd, 2000.

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16

Acute Perinatal Asphyxia in Term Infants: Report of the Workshop. Diane Pub., 1996.

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17

Hanrahan, John Donncha. The use of magnetic resonance spectroscopy in infants following perinatal hypoxic-ischaemic injury. 1997.

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18

F, Kubli, and International Federation of Gynecology and Obstetrics. Committee on Perinatal Mortality and Morbidity., eds. Perinatal events and brain damage in surviving children. Berlin: Springer-Verlag, 1988.

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19

Goeral, Katharina, Ali Fatemi, and Michael V. Johnston. Neonatal Brain Injuries. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0072.

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Neonatal brain injuries (NBIs) are important causes of motor and neurocognitive disabilities in children worldwide. This chapter discusses the most common types of NBIs in developed countries, namely neonatal encephalopathy associated with birth asphyxia in term infants, perinatal arterial ischemic stroke, perinatal white matter injury, and germinal matrix hemorrhage and neonatal hydrocephalus. Epidemiologic studies suggest that prenatal stressors, including intrauterine inflammation, maternal drug/toxin exposure, and placental pathologies are key players in the etiology of NBIs, whereas genetic contributors are yet to be identified. Hypothermia has become a standard neuroprotective strategy in neonatal encephalopathy, and novel therapeutics are currently being evaluated.
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20

Chang, Eugene. Neuroprotection for Premature Birth and Neonatal Brain Injury. Edited by David L. Reich, Stephan Mayer, and Suzan Uysal. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190280253.003.0014.

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Preterm birth is associated with increased risk of perinatal brain injury. Although there has been little headway made in reducing preterm birth rates, survival of infants born prematurely has improved greatly. Because of this, the neurodevelopmental consequences related to prematurity have become significant issues, especially in those infants born at less than 32 weeks gestation. Hypoxic-ischemic encephalopathy commonly leads to neonatal brain injury both before and after delivery. While perinatal birth asphyxia accounts for a proportion of neonatal brain injury in neonates younger than 37 weeks, preterm birth is the more significant risk factor. This chapter explores the neurodevelopmental consequences associated with preterm birth, the pathophysiology of perinatal brain injury, and the imaging modalities used to assess the newborn brain. Finally, various neuroprotective interventions in clinical use and in development will be described.
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21

Felling, Ryan J. Targets for Neuroprotection in Ischemic Stroke. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0111.

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Cerebral ischemia or hypoxia-ischemia initiate a cascade of biochemical events including impaired reuptake of glutamate into perisynaptic glia causing glutamate flooding, calcium fluxing through NMDA glutamate channels, activation of neuronal nitric oxide synthetase, and impaired mitochondrial ATP production. In animal models it is possible to block these steps and protect the brain but the temporal window of protection after the insult lasts only a few hours. Recombinant TPA is clinically protective if given within 3 hours of stroke, but other agents have not been shown to protect brain tissue after stroke. However, total body cooling has also been shown to protect the brain of term infants if initiated within 6 hours of perinatal asphyxia, and a similar level of cooling may provide protection for the brain in adults who have been resuscitated after cardiac arrest.
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