Journal articles: 'Perinatal asphyxia'

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Lansac, Jacques. "Perinatal asphyxia." European Journal of Obstetrics & Gynecology and Reproductive Biology 52, no. 1 (November 1993): 77. http://dx.doi.org/10.1016/0028-2243(93)90230-a.

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Brouwer, O. F. "Perinatal asphyxia." Journal of the Neurological Sciences 120, no. 1 (December 1993): 121. http://dx.doi.org/10.1016/0022-510x(93)90037-y.

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Leviton, Alan. "Perinatal asphyxia." Pediatric Neurology 3, no. 2 (March 1987): 123. http://dx.doi.org/10.1016/0887-8994(87)90043-9.

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Jain, Dr Dharmendra, Dr Akash Kumar Pandey, Dr B. K. Das, and Dr Rajniti Prasad. "Cardiac Function in Perinatal Asphyxia." Scholars Journal of Applied Medical Sciences 4, no. 7 (July 2016): 2718–28. http://dx.doi.org/10.21276/sjams.2016.4.7.87.

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Gold, J. R. "Perinatal asphyxia syndrome." Equine Veterinary Education 29, no. 3 (December 1, 2015): 158–64. http://dx.doi.org/10.1111/eve.12467.

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Herrera, María Inés, Matilde Otero-Losada, Lucas Daniel Udovin, Carlos Kusnier, Rodolfo Kölliker-Frers, Wanderley de Souza, and Francisco Capani. "Could Perinatal Asphyxia Induce a Synaptopathy? New Highlights from an Experimental Model." Neural Plasticity 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/3436943.

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Birth asphyxia also termed perinatal asphyxia is an obstetric complication that strongly affects brain structure and function. Central nervous system is highly susceptible to oxidative damage caused by perinatal asphyxia while activation and maturity of the proper pathways are relevant to avoiding abnormal neural development. Perinatal asphyxia is associated with high morbimortality in term and preterm neonates. Although several studies have demonstrated a variety of biochemical and molecular pathways involved in perinatal asphyxia physiopathology, little is known about the synaptic alterations induced by perinatal asphyxia. Nearly 25% of the newborns who survive perinatal asphyxia develop neurological disorders such as cerebral palsy and certain neurodevelopmental and learning disabilities where synaptic connectivity disturbances may be involved. Accordingly, here we review and discuss the association of possible synaptic dysfunction with perinatal asphyxia on the basis of updated evidence from an experimental model.

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Thompson, Debbie Gearner. "Consequences of Perinatal Asphyxia." AACN Advanced Critical Care 5, no. 3 (August 1, 1994): 242–45. http://dx.doi.org/10.4037/15597768-1994-3003.

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Perinatal asphyxia occurs in 3–9 of every 1,000 births. The risk for perinatal asphyxia is present in every pregnancy. When asphyxia is diagnosed in a newborn, the effects on the infant are potentially life-threatening. Management of the asphyxia focuses on initial stabilization and support based on identified organ system dysfunction as well as support for the infant’s family. Long-term outcome for the asphyxiated infant is related to the degree, duration, and resolution of organ system dysfunction

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., Siddharth, Preeti Lata Rai, and P. L. Prasad. "Urinary uric acid or urinary creatinine ratio as a non-invasive marker for perinatal asphyxia." International Journal of Contemporary Pediatrics 7, no. 6 (May 22, 2020): 1378. http://dx.doi.org/10.18203/2349-3291.ijcp20202151.

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Background: Perinatal asphyxia is amongst the common problem of neonates and there exists a significant contribution to the neonatal morbidity and mortality. It is observed as a common and a vital cause of the preventable cerebral injury. The prediction of the perinatal asphyxial outcome is very important but dreadful. There is a limited role for APGAR score to predict the immediate outcome, like HIE and the long-term neurological sequelae observational error may happen in APGAR. But the biochemical parameters can truly be relied upon. This study was done to assess urinary uric acid/urinary creatinine ratio (UA/Cr) as a non-invasive marker for perinatal asphyxia and co-relate its absolute value to the degree of the perinatal asphyxia.Methods: In this prospective case control study conducted in the Pediatrics Department of Shri Ram Murti Smarak Institute of Medical Sciences between Nov 2017 to May 2019, 42 asphyxiated and 42 non-asphyxiated newborns were included. Detailed history and assessment were for all the enrolled newborns. Spot urine samples were sent for the uric acid and creatinine estimation. Results were documented, and statistical analysis was performed.Results: Urinary uric acid to creatinine ratio used as additional non-invasive, early and easy biochemical marker of the birth asphyxia that biochemically supports severity grading and clinical diagnosis of the asphyxia by APGAR score.Conclusions: The ratio of the urinary uric acid and creatinine enables rapid and early recognition of asphyxial injury and also the evaluation of its severity and potential for short-term morbidity or death.

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Gebreheat, Gdiom, Tesfay Tsegay, Dessalegn Kiros, Hirut Teame, Natnael Etsay, Guesh Welu, and Desta Abraha. "Prevalence and Associated Factors of Perinatal Asphyxia among Neonates in General Hospitals of Tigray, Ethiopia, 2018." BioMed Research International 2018 (November 1, 2018): 1–7. http://dx.doi.org/10.1155/2018/5351010.

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Perinatal asphyxia is one of the most important causes of morbidity and mortality in neonates. Perinatal asphyxia occurs in association with maternal, fetal, and maternofetal factors. However, the magnitude and associated factors of perinatal asphyxia are not well studied in Tigray, Ethiopia. Therefore, our study is conducted to determine the prevalence and factors associated with perinatal asphyxia among neonates in general hospitals of Tigray. An observational hospital-based cross-sectional study was conducted in randomly selected general hospitals. A semistructured questionnaire was used to collect data from 421 randomly selected neonates with their mothers and medical records. The data was entered into epidata version 3.5 and exported to Statistical Package for Social Sciences (SPSS) version 20 for analysis. Finally, the presence of an association between a dependent variable and an independent variables has been declared at P-value ≤0.05, or adjusted odds ratio (AOR), 95% confidence interval (CI). Accordingly, the result of this study showed that the prevalence of perinatal asphyxia among the selected general hospitals was 22.1%. Neonates born with cesarean section are seven times more likely to have perinatal asphyxia than those who are born spontaneously through the vagina (AOR, 6.97; CI (2.87-16.93)). In addition, neonates who are born meconium stained are 8.55 times more likely to have perinatal asphyxia than those who had not stained with meconium (AOR, 8.55; CI (4.20-17.39)). Neonates who are weighed less than 2.5 kg are 12.75 times more likely to have perinatal asphyxia than those who are weighed 2.5-4 kg (AOR, 12.75; CI (4.05-40.08)). Prolonged duration of labour was also associated statistically with perinatal asphyxia (AOR, 3.33, CI (1.32-8.38)). In conclusion, the magnitude of perinatal asphyxia in general hospitals of Tigray remains high. Low birth weight, meconium-stained amniotic fluid, cesarean section, and prolonged maternal labour have been associated with perinatal asphyxia.

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Leone, C. R., and N. O. E. Barbosa. "Magnesium and Perinatal Asphyxia." NeoReviews 8, no. 9 (August 31, 2007): e387-e393. http://dx.doi.org/10.1542/neo.8-9-e387.

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Donn, Steven M. "Phenobarbital and perinatal asphyxia." Journal of Pediatrics 133, no. 5 (November 1998): 714. http://dx.doi.org/10.1016/s0022-3476(98)70123-4.

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Williams, Chris E., Carina Mallard, William Tan, and Peter D. Gluckman. "Pathophysiology of Perinatal Asphyxia." Clinics in Perinatology 20, no. 2 (June 1993): 305–25. http://dx.doi.org/10.1016/s0095-5108(18)30395-6.

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Hill, Alan, and Joseph J. Volpe. "Perinatal Asphyxia: Clinical Aspects." Clinics in Perinatology 16, no. 2 (June 1989): 435–57. http://dx.doi.org/10.1016/s0095-5108(18)30640-7.

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Hollander, David I., Linda Wright, David A. Nagey, John N. Wright, Marcos J. Pupkin, and Thomas Koch. "Indicators of perinatal asphyxia." American Journal of Obstetrics and Gynecology 157, no. 4 (October 1987): 839–43. http://dx.doi.org/10.1016/s0002-9378(87)80068-6.

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Ellis, Matthew, and Dharma Manandhar. "Progress in perinatal asphyxia." Seminars in Neonatology 4, no. 3 (August 1999): 183–91. http://dx.doi.org/10.1016/s1084-2756(99)90060-x.

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HOLLANDER, D., L. WRIGHT, D. NAGERY, J. WRIGHT, M. PUPKIN, and AND T. KOCH. "Indicators of Perinatal Asphyxia." Survey of Anesthesiology XXXII, no. 4 (August 1988): 247. http://dx.doi.org/10.1097/00132586-198808000-00037.

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Menkes, John H. "Definition of perinatal asphyxia." Journal of Pediatrics 114, no. 1 (January 1989): 168. http://dx.doi.org/10.1016/s0022-3476(89)80632-8.

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Thoresen, Marianne. "Cooling after perinatal asphyxia." Seminars in Fetal and Neonatal Medicine 20, no. 2 (April 2015): 65. http://dx.doi.org/10.1016/j.siny.2015.01.003.

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., Sambedna, Amit Kumar, and Rita Chakore. "Outcomes and analysis of fetomaternal elements and delivery strategies with neonatal respiratory distress." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 10, no. 5 (April 23, 2021): 2001. http://dx.doi.org/10.18203/2320-1770.ijrcog20211527.

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Background: Perinatal asphyxia is one of the most important causes of morbidity and mortality in neonates. Perinatal asphyxia occurs in association with different maternal and fetal determinants. However, the relation of associated factors with perinatal asphyxia is not well studied. The aim of this study was to determine the association of maternofetal factors and mode of delivery with perinatal asphyxia in a tertiary care centre.Methods: This was a retrospective comparative study conducted in department of OBG in tertiary care health centre. A total 200 newborns were selected for study out of which100 newborns were with asphyxia at birth as study group and 100 non asphyxiated newborns were taken as control group. Maternal factor like age, parity, gestational age and fetal factor like weight at birth and mode of delivery were studied to established association on perinatal asphyxia.Results: Maternal factor like age, parity, gestational age had not significant relationship with perinatal asphyxia. Maximum number of babies delivered in both control and the study group were in the range of 2.6 to 3kg.In this study birth weight did not have significant relationship with perinatal asphyxia. Proportions of LSCS was comparatively higher in the study group though. The delivery mode did not have any statistically significant influence on the newborns affliction with birth asphyxia (p>0.05).Conclusions: Findings of this study highlight the need for the better obstetrical care and awareness of the possible presence of the risk factors of PNA (perinatal asphyxia) among mothers and fetus, so that the incidence and complications of PNA could be prevented or at least appropriately managed. It can reduce the high incidence of morbidity and mortality due to birth asphyxia.

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Ogundele, Tolulope, Saheed Babajide A. Oseni, Joshua A. Owa, and Olorunfemi Ogundele. "Lactate Dehydrogenase, Aspartate Aminotransferase, and Alanine Aminotransferase Cord Serum Levels as Early Markers of Hypoxic–Ischemic Encephalopathy in Babies with Severe Perinatal Asphyxia." Journal of Pediatric Neurology 17, no. 03 (January 28, 2018): 105–10. http://dx.doi.org/10.1055/s-0037-1621725.

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AbstractPerinatal asphyxia is a major cause of morbidity and mortality among newborn babies. Severe perinatal asphyxia can be associated with multiple organ dysfunctions resulting in the release of a variety of intracellular enzymes. A major concern is how to identify newborns in need of prompt and aggressive management to minimize the risk of early severe neurological sequelae such as hypoxic–ischemic encephalopathy. The present study was performed to determine the relationship between cord serum levels of lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase, and severity of perinatal asphyxia among Nigerian newborn babies. This was a prospective, comparative case–control study at the Obafemi Awolowo University Teaching Hospital, Ile-Ife. Cord blood was collected at delivery for serum levels of lactate dehydrogenase, aspartate aminotransferase, and alanine aminotransferase. Each baby was evaluated for the severity of perinatal asphyxia at 1 minute of life using Apgar scores. Apgar score less than 7 at 1 minute was regarded as perinatal asphyxia. The Apgar scores were related to cord serum levels of the enzymes. The data were analyzed using Statistical Package for the Social Sciences for Windows, version 17.0. One hundred and forty babies, comprising 70 babies with and 70 babies without perinatal asphyxia were studied. Thirty-six (51.4%) of the neonates had severe perinatal asphyxia with Apgar score of 3 and below; 15 (41.7%) of the 36 had hypoxic–ischemic encephalopathy. The mean of values of each of the three enzymes was statistically significantly higher in babies with perinatal asphyxia compared with controls (p < 0.001 for each enzyme) and in babies with hypoxic–ischemic encephalopathy than in babies with severe perinatal asphyxia but without hypoxic–ischemic encephalopathy (p < 0.001). A very high proportion of babies with severe perinatal asphyxia developed hypoxic–ischemic encephalopathy. Based on the cord serum enzyme levels, almost all the babies who had hypoxic–ischemic encephalopathy would have been identified at delivery. Routine estimation of the cord serum levels of these enzymes among babies with severe perinatal may be used to identify babies who may develop acute serious neurological complications for anticipatory management.

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Ao, Deng, Shuai Guo, Chunfeng Yun, and Xiaoying Zheng. "Socio-demographic factors impact disabilities caused by perinatal asphyxia among Chinese children." PLOS ONE 16, no. 3 (March 5, 2021): e0248154. http://dx.doi.org/10.1371/journal.pone.0248154.

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BackgroundDisabilities caused by perinatal asphyxia will burden child health and well-being. To date, our understanding about the situation and risk factors of perinatal asphyxia-induced disabilities among Chinese children is still limited.ObjectivesTo evaluate the prevalence and socio-demographic risk factors of disabilities caused by perinatal asphyxia among Chinese children in 2006 and compare disability trajectories across different socio-demographic status.MethodsCross-sectional data came from the 2006 China National Survey on Disability which includes a total of 616,940 children aged 0–17 years old was employed in the investigation. Perinatal asphyxia-induced disabilities were identified by following the guidance in consensus manuals. Population-weighted numbers and prevalence rates were investigated, and multivariable logistic regression was performed to evaluate associations between disabilities and socio-demographic factors. Adjusted predictions at representative values were computed to compare the disability trajectories relative to significant socio-demographic variables.ResultsThe prevalence rate of disabilities caused by perinatal asphyxia was 7.70 per 10,000 children (95% CI: 7.01–8.39). Male (OR 1.81, 95% CI: 1.47–2.23) and low family income (OR: 1.73, 95% CI: 1.21–2.49) have higher and the increase of per additional year of age (OR: 0.89, 95% CI: 0.88–0.91) has lower probability of being disabilities caused by perinatal asphyxia. Further disability trajectories showed that differences in probability between gender and family income group were more evident before age 7 and weakened with increasing age.ConclusionsOur results showed that both demographic and socioeconomic characteristics are risk factors for disabilities caused by perinatal asphyxia. Of these, gender and family income have much higher impact than other factors on the prevalence rate of disabilities caused by perinatal asphyxia at infants and young children. Multiple society sectors should increase their effort to bring about fundamental social change to prevent disabilities caused by perinatal asphyxia, especially concerning younger children and their families.

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., Sambedna, Amit Kumar, and Rita Chakore. "Study of relationship between umbilical cord blood hemoglobin percentage and perinatal asphyxia." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 10 (September 25, 2020): 4114. http://dx.doi.org/10.18203/2320-1770.ijrcog20204297.

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Background: Perinatal asphyxia may be caused by perinatal anemia. The pathophysiology and neurodevelopment effects are theoretically different from other causes of fetal asphyxia. Severe asphyxia can occur in infants around the time of birth by various reasons. The aim of this study to find the relationship between cord blood hemoglobin and perinatal asphyxia.Methods: This was a retrospective comparative study in department of OBG In tertiary care health centre. Umbilical cord blood samples were collected from 100 newborns with asphyxia at birth as study group and 100 newborns with non asphyxia as control group. Hemoglobin was measured colorimetrically.Results: This study finds that maximum number of patients in both the control and study group had hemoglobin in the range of 16.3-17.3 gm/dl. The difference was not statistically significant. P value>0.05.Conclusions: Hematological changes observed early after delivery can determine the duration of hypoxemia (acute versus chronic) Perinatal anemia causing moderate to severe perinatal asphyxia is associated with a higher risk for neonatal mortality. All survivors with perinatal anemia, however, showed no abnormalities in neurodevelopment in contrast to children who were born asphyxiated due to various another causes. The underlying pathophysiological mechanism for the favorable NDO in the perinatal anemia group needs further elucidation.

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Gebregziabher, Gebrehiwot Teklehaimanot, Fikaden Berhe Hadgu, and Haftom Temesgen Abebe. "Prevalence and Associated Factors of Perinatal Asphyxia in Neonates Admitted to Ayder Comprehensive Specialized Hospital, Northern Ethiopia: A Cross-Sectional Study." International Journal of Pediatrics 2020 (February 14, 2020): 1–8. http://dx.doi.org/10.1155/2020/4367248.

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Background. Perinatal asphyxia is defined as the inability of the newborn to initiate and sustain enough respiration after delivery and is characterized by a marked impairment of gas exchange. It is one of the most common causes of neonatal mortality and morbidity. There are very few studies on perinatal asphyxia in Tigray, and so this study is aimed at assessing the prevalence and associated factors of perinatal asphyxia in Ayder Comprehensive Specialized Hospital NICU, Tigray, Ethiopia. Methods. An institution-based cross-sectional study design was conducted among neonates admitted to Ayder Comprehensive Specialized Hospital from January 1, 2016, to December 30, 2017. Medical records of 267 neonates admitted to the neonatal intensive care unit were selected by a systematic sampling method, and relevant information was collected using a checklist. The data was analyzed using SPSS version 20. Descriptive statistics were computed to determine the prevalence of birth asphyxia and sociodemographic and obstetrics data. Binary logistic regression was used to test associations between the associated factors and perinatal asphyxia. First bivariate analysis was performed to assess the association without controlling the effect of other independent variables. Variables with P value < 0.25 were fitted to the multivariable binary logistic regression model. Finally, variables with P value < 0.05 were expressed as associated factors of perinatal asphyxia. Results. Of the 267 neonates, 48 neonates had perinatal asphyxia, giving a prevalence of 18%. Prolonged labor (AOR=5.19, 95% CI: 1.73-15.63, P=0.003), presence of meconium (AOR=4.17, 95% CI: 1.34-12.98, P=0.014), and preeclampsia (AOR=7.94, 95% CI: 2.22-28.37, P=0.001) were important determinant factors for birth asphyxia. The case fatality rate of perinatal asphyxia was 37.5%. Conclusion and Recommendations. Prevalence and mortality of asphyxia were high. Prolonged labor, presence of meconium, and preeclampsia were determinant factors for birth asphyxia. Early detection and intervention of high-risk mothers should be carried out by health care providers, and mothers should be monitored with partograph during labor.

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Jamie, Arif Hussen, and Mohammed Z. Abdosh. "Prevalence and Risk Factors of Perinatal Asphyxia in a Tertiary Care Level Hospital, Harari Regional State, Ethiopia." Journal of Nepal Paediatric Society 39, no. 2 (December 31, 2019): 103–8. http://dx.doi.org/10.3126/jnps.v39i2.26408.

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Introduction: Globally birth asphyxia continues to present a major clinical problem. It is one of the common and leading causes of perinatal and neonatal mortality and morbidity especially in developing countries. Methods: A cross-sectional study was conducted among newborns in a tertiary level hospital, Ethiopia from February to July 2019. Systematic random sampling technique was used to select the study subjects. Multivariate logistic regression analysis was used to identify factors associated with the perinatal asphyxia among newborns. Results: Of the newborns, 32% had perinatal asphyxia and factors significantly associated were anaemia during pregnancy (adjusted OR = 2.99, 95% CI: 1.07 – 8.35), chronic hypertension (adjusted OR = 4.89, 95% CI: 1.16 – 20.72) and low birth weight newborns (adjusted OR = 3.31, 95% CI: 1.308 – 8.37). Conclusions: Maternal anaemia during pregnancy, chronic hypertension and low birth weight were significantly associated with perinatal asphyxia. Therefore, early screening and appropriate intervention during pregnancy and intra-partum might reduce perinatal asphyxia among newborns.

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Millichap, J. Gordon. "Brainstem Injury from Perinatal Asphyxia." Pediatric Neurology Briefs 2, no. 2 (February 1, 1988): 14. http://dx.doi.org/10.15844/pedneurbriefs-2-2-11.

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Millichap, J. Gordon. "Melatonin and Experimental Perinatal Asphyxia." Pediatric Neurology Briefs 27, no. 3 (March 1, 2013): 19. http://dx.doi.org/10.15844/pedneurbriefs-27-3-4.

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Millichap, J. Gordon. "Dystonia Due to Perinatal Asphyxia." Pediatric Neurology Briefs 5, no. 3 (March 1, 1991): 24. http://dx.doi.org/10.15844/pedneurbriefs-5-3-11.

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Wagdy, El-SayedA, EbrahimT Hasan, and EassaA Eman. "Interleukin-1β in perinatal asphyxia." Benha Medical Journal 33, no. 2 (2016): 95. http://dx.doi.org/10.4103/1110-208x.201289.

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Doreswamy, Dr Srinivasa Murthy, and Dr Vani Krishnamurthy. "Coagulation Profile in Perinatal Asphyxia." Pediatric Review: International Journal of Pediatric Research 2, no. 4 (December 31, 2015): 37–40. http://dx.doi.org/10.17511/ijpr.2015.i04.01.

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Rabindran, Dr Rabindran, and Dr D. Sharad Gedam. "Therapeutic Hypothermia in Perinatal Asphyxia." Pediatric Review: International Journal of Pediatric Research 3, no. 2 (February 29, 2016): 124–29. http://dx.doi.org/10.17511/ijpr.2016.i02.10.

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Fan, Xiyong, and Frank van Bel. "Pharmacological neuroprotection after perinatal asphyxia." Journal of Maternal-Fetal & Neonatal Medicine 23, sup3 (August 9, 2010): 17–19. http://dx.doi.org/10.3109/14767058.2010.505052.

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Dattilo, Giuseppe, Viviana Tulino, Domenico Tulino, Annalisa Lamari, Gabriella Falanga, Filippo Marte, and Salvatore Patanè. "Perinatal asphyxia and cardiac abnormalities." International Journal of Cardiology 147, no. 2 (March 2011): e39-e40. http://dx.doi.org/10.1016/j.ijcard.2009.01.032.

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Donn, S. M. "Perinatal asphyxia and cardiac abnormalities." Yearbook of Neonatal and Perinatal Medicine 2011 (January 2011): 24–25. http://dx.doi.org/10.1016/j.ynpm.2011.04.018.

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Kumar, Ashok, Satya Venkata Kalyan Ramakrishna, Sriparna Basu, and Gatram Rama Koteshwara Rao. "Oxidative Stress in Perinatal Asphyxia." Pediatric Neurology 38, no. 3 (March 2008): 181–85. http://dx.doi.org/10.1016/j.pediatrneurol.2007.10.008.

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Edwards, A. D. "Therapeutic hypothermia following perinatal asphyxia." Archives of Disease in Childhood - Fetal and Neonatal Edition 91, no. 2 (March 1, 2006): F127—F131. http://dx.doi.org/10.1136/adc.2005.071787.

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Marks, Warren A., Richard W. Leech, and Geoffrey P. Altshuler. "Placental Examination in Perinatal Asphyxia." Journal of Child Neurology 4, no. 2 (April 1989): 124. http://dx.doi.org/10.1177/088307388900400209.

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Tarcan, Aylin, Filiz Ti˙ker, Hakan Güvenir, and Berkan Gürakan. "Hepatic involvement in perinatal asphyxia." Journal of Maternal-Fetal & Neonatal Medicine 20, no. 5 (January 2007): 407–10. http://dx.doi.org/10.1080/14767050701287459.

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Gunn, A. J., C. E. Williams, L. Bennet, C. J. Cook, and P. D. Gluckman. "Perinatal Cerebral Asphyxia: Pharmacological Intervention." Fetal Diagnosis and Therapy 3, no. 1-2 (1988): 98–107. http://dx.doi.org/10.1159/000263339.

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Locci, Emanuela, Giovanni Bazzano, Roberto Demontis, Alberto Chighine, Vassilios Fanos, and Ernesto d’Aloja. "Exploring Perinatal Asphyxia by Metabolomics." Metabolites 10, no. 4 (April 4, 2020): 141. http://dx.doi.org/10.3390/metabo10040141.

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Brain damage related to perinatal asphyxia is the second cause of neuro-disability worldwide. Its incidence was estimated in 2010 as 8.5 cases per 1000 live births worldwide, with no further recent improvement even in more industrialized countries. If so, hypoxic-ischemic encephalopathy is still an issue of global health concern. It is thought that a consistent number of cases may be avoided, and its sequelae may be preventable by a prompt and efficient physical and therapeutic treatment. The lack of early, reliable, and specific biomarkers has up to now hampered a more effective use of hypothermia, which represents the only validated therapy for this condition. The urge to unravel the biological modifications underlying perinatal asphyxia and hypoxic-ischemic encephalopathy needs new diagnostic and therapeutic tools. Metabolomics for its own features is a powerful approach that may help for the identification of specific metabolic profiles related to the pathological mechanism and foreseeable outcome. The metabolomic profiles of animal and human infants exposed to perinatal asphyxia or developing hypoxic-ischemic encephalopathy have so far been investigated by means of 1H nuclear magnetic resonance spectroscopy and mass spectrometry coupled with gas or liquid chromatography, leading to the identification of promising metabolomic signatures. In this work, an extensive review of the relevant literature was performed.

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BEDRICK, ALAN D. "Perinatal Asphyxia and Cerebral Palsy." American Journal of Diseases of Children 143, no. 10 (October 1, 1989): 1139. http://dx.doi.org/10.1001/archpedi.1989.02150220027014.

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Bhatti, Anuj, and Praveen Kumar. "Systemic Effects of Perinatal Asphyxia." Indian Journal of Pediatrics 81, no. 3 (February 12, 2014): 231–33. http://dx.doi.org/10.1007/s12098-013-1328-9.

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Naithani, Manisha, and Ashish Kumar Simalti. "Biochemical Markers in Perinatal Asphyxia." Journal of Nepal Paediatric Society 31, no. 2 (May 6, 2011): 151–56. http://dx.doi.org/10.3126/jnps.v31i2.4155.

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Early assessment of the severity of an acute cerebral lesion secondary to hypoxia-ischemia or other pathologic conditions may provide a very useful basis for preventive or therapeutic decisions in pediatric patients. In the present review, we discuss the diagnostic and prognostic value of a series of biochemical parameters, with special reference to the diagnosis of neonatal HIE. Currently many specific biochemical markers of brain injury are being investigated to assess regional brain damage after perinatal asphyxia in neonates of which serum protein S-100β, brain-specific creatine kinase, neuron-specific enolase, IL6 and urinary uric acid levels appear promising in identifying patients with a risk of developing hypoxic-ischemic encephalopathy. Whether detection of elevated serum concentrations of these proteins reflects long-term neurodevelopmental impairment remains to be investigated. Key words: S-100; Brain specific creatine kinase; neuron specific enolase; IL6; urinary uric acid; hypoxic ischaemic cerebral injury. DOI: 10.3126/jnps.v31i2.4155 J Nep Paedtr Soc 2010;31(2):151-156

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Brown, J. K., R. J. Purvis, J. O. Forfar, and F. Cockburn. "Neurological Aspects of Perinatal Asphyxia." Developmental Medicine & Child Neurology 16, no. 5 (November 12, 2008): 567–80. http://dx.doi.org/10.1111/j.1469-8749.1974.tb04176.x.

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de Haan, Harmen H., and Tom H. M. Hasaart. "Neuronal death after perinatal asphyxia." European Journal of Obstetrics & Gynecology and Reproductive Biology 61, no. 2 (August 1995): 123–27. http://dx.doi.org/10.1016/0301-2115(95)02127-s.

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Nishijima, Takaharu, Yukako Kawasaki, Kazuyuki Ueno, Satomi Inomata, and Taketoshi Yoshida. "Renal impairment following perinatal asphyxia." Pediatrics & Neonatology 62, no. 4 (July 2021): 451–52. http://dx.doi.org/10.1016/j.pedneo.2021.01.010.

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Chikkanna, Somashekhar, Saravanan P., Nagaraj M. V., and Kavya S. "Evaluation of the immediate outcomes of perinatally asphyxiated newborns in a tertiary care hospital in rural Bangalore: a retrospective study." International Journal of Contemporary Pediatrics 7, no. 11 (October 21, 2020): 2133. http://dx.doi.org/10.18203/2349-3291.ijcp20204445.

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Background: Perinatal asphyxia is a condition resulting from deprivation of oxygen to a neonate that lasts long enough to cause damage to the brain. Perinatal asphyxia is one of the major causes of early neonatal mortality in India. The goal was to evaluate outcomes of asphyxiated babies. Methods: One hundred consecutive neonates with birth asphyxia (Apgar 0-3 at 5-minute of age) were studied. Data from medical records of all babies with perinatal asphyxia admitted were retrieved and documented for the study.Results: Majority of the neonates are inborn (57%). Male to female ratio was 1.5:1. Spontaneous vaginal delivery constitute 32% and lower segment caesarean section (LSCS) 36%. Mortality was highest in hypoxic ischemic encephalopathy (HIE) stage 3 with 11%. Mean duration of hospitalization is directly related to Sarnat and Sarnat staging of HIE. 22% babies were having neurological sequelae and discharged on anti-convulsant. 21% mortality, majority were outborn.Conclusions: Despite advances in the management of neonates, perinatal asphyxia is still the leading cause of morbidity and mortality. Perinatal asphyxia is still prevalent despite medical advances. Babies with HIE stage III had poor outcome. Appropriate strategies required to minimize the neuro-developmental sequelae.

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Ganta, Suvarna Jyothi, and Sunanda R. Kulkarni. "Study of cord blood nucleated RBC’s as a marker for fetal asphyxia." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 2 (January 31, 2017): 658. http://dx.doi.org/10.18203/2320-1770.ijrcog20170402.

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Background: Perinatal asphyxia is a serious problem globally and is a common cause of neonatal mortality and long term morbidity. Various Parameters are being used as predictors for birth asphyxia but the correlation between clinical presentation and the biochemical results has been unsatisfactory. NRBC count of the cord blood is reported in literature as a possible marker of perinatal asphyxia. In-utero hypoxic episode may induce a haemopoetic response of exaggerated erythropoiesis leading to the presence of nucleated RBC's in fetal circulation. The aim of this study was to investigate whether NRBC count of the cord blood can be a useful parameter to determine perinatal asphyxia.Methods: This prospective case control study was conducted in Chinmaya Mission hospital, Bangalore, India between July 2015 to June 2016.we have studied the NRBC counts from the cord blood of 50 neonates with perinatal asphyxia and 50 healthy neonates, thus comparing the results.Results: The mean NRBC /100 WBC for cases with birth asphyxia was 11.6 and that of the control group was 5.6. NRBC count was found to be significantly higher in neonates with low Apgar scores. There was correlation between the Apgar scores at 1st and at 5 minutes, the degree of Hypoxic Ischemic Encephalopathy and the NRBC counts.Conclusions: Therefore NRBC counts of the cord blood can be used as an effective tool to confirm perinatal asphyxia. It is a simple, quick, accurate and clinically effective test to diagnose and initiate treatment to prevent long term sequel of perinatal asphyxia.

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Mehar, Muhammad Faisal, Muhammad Azam Khan, Rabia Saleem, Fauzia Zafar, Ali Bakht Naqqash, Sidra Shahid, and Rushan Hassan. "Risk factors of perinatal asphyxia at Nishtar Hospital Multan." Professional Medical Journal 27, no. 03 (March 10, 2020): 487–92. http://dx.doi.org/10.29309/tpmj/2020.27.03.3176.

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Many perinatal deaths follow birth asphyxia that occurs in babies of women who are referred on developing life-threatening obstetric complications. Objectives: To determine the antenatal and intrapartum risk factors for perinatal asphyxia among babies delivered by women admitted as emergency obstetric referrals. Study Design: Cross-sectional study. Setting: Pediatric Unit 1, Nishtar Hospital Multan, Pakistan. Period: From May 2017 to April 2018. Material & Methods: A total of 150 newborn term babies (and their mothers) with a 1, 5, & 10-minutes Apgar score 4 or less (perinatal asphyxia) were considered for the study. Antepartum and intraparturn risk factors were noted among newborn babies (and their mothers) from socio-demographic characteristics, obstetric complications or labour management. Results: Out of150 neonates, 57(38%) were presented with perinatal asphyxia at the age of 1 minute, 62(41.3%) at the age of 5 minutes and 31(20.1%) neonates were presented at the age of 10 minutes. In these cases, 45(30%) were related to maternal causes, 71(47.3%) to placental causes and 34(22.7%) to fetal cause. Conclusions: Early recognition of antepartum and intraparturn risk factors for perinatal axphyxiaamong emergency obstetric referrals, followed by prompt and appropriate management, may reduce the perinatal deaths from perinatal asphyxia.

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Shinde, Rajendra, Kiran Haridas, Madhavi Shelke, L. S. Deshmukh, and P. S. Patil. "A study on clinical correlation of EEG in neonates with perinatal asphyxia." International Journal of Contemporary Pediatrics 6, no. 2 (February 23, 2019): 390. http://dx.doi.org/10.18203/2349-3291.ijcp20190683.

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Background: Perinatal asphyxia is the most common and important cause of preventable cerebral injury occurring in the neonatal period. The WHO has estimated that 4 million babies die during the neonatal period every year. According to WHO, perinatal asphyxia is defined as the failure to initiate and sustain breathing at birth. The objective is to study the electroencephalographic changes and correlation between severity of Perinatal asphyxia with EEG changes.Methods: It is prospective observational study, which includes 40 term neonates admitted in NICU with perinatal asphyxia in GMCH Aurangabad. EEG analysis focused on background activity and classified into four categories.Results: The EEG was normal in 45%, mild abnormal in 25%, intermediate in 15%, and severely abnormal in 15%. Outcome at discharge was normal in 19(47.5%) and abnormal in 21(52.5%) including 1 death. Abnormal outcome was seen in 27% of newborns with normal EEG and 72% of abnormal EEG.Conclusions: Severity of perinatal asphyxia correlated well with abnormality of EEG. EEG changes and severity showed good correlation with immediate outcome of newborn in terms of duration of hospitalization and normal neurological examination.

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Singh, Sandip Kumar, Shikha Rijal, and Arun Giri. "Correlation of Serum LDH Level in Perinatal Ashyxia as a Marker of Hypoxic Ischemic Encephalopathy." Birat Journal of Health Sciences 4, no. 3 (January 3, 2020): 850–54. http://dx.doi.org/10.3126/bjhs.v4i3.27039.

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Introduction: Perinatal Asphyxia is common cause of multiorgan dysfunction in neonates. It leads to significant mortality and morbidity. Serum lactate dehydrogenase (LDH), if measured can differentiate asphyxiated neonates from non-asphyxiated neonates. Objectives: To find whether serum LDH can distinguish an asphyxiated from a non-asphyxiated term neonate. To co-relate serum LDH level in perinatal asphyxia with various stages of HIE and to see whether it can predict mortality. Methodology: This is a prospective study done from June 2018 to May 2019 in NICU of Nobel Medical College, on child with Perinatal Asphyxia. All neonates included in the study underwent thorough clinical and neurological examination. Severity of HIE was done by Sarnat & Sarnat staging criteria. Serum LDH level were measured in all the cases. Statistical analysis was done using SPSS 11. Results: 90 neonates with perinatal asphyxia were enrolled and 30 normal neonates were enrolled as controls. The number of neonates with LDH level > 600U/L was significantly more in cases with perinatal asphyxia group as compared to controls (non-asphyxiated) with ‘p’ < 0.001. Serum LDH level was progressively high in relation to stages of HIE and difference between mean LDH level between neonates expired and survived was statistically significant with ‘p’ <0.001. Conclusion: Serum LDH level is a reliable indicator of perinatal asphyxia and helps to differentiate different stages of HIE.

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Journal articles on the topic 'Perinatal asphyxia'

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