Journal articles: 'Periodic regulation'

1

HELM, DIETER, and NAJMA RAJAH. "Water Regulation: The Periodic Review." Fiscal Studies 15, no. 2 (May 1994): 74–94. http://dx.doi.org/10.1111/j.1475-5890.1994.tb00198.x.

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Ichikawa, Akira, and Hitoshi Katayama. "Output regulation of periodic systems." IFAC Proceedings Volumes 37, no. 12 (August 2004): 225–30. http://dx.doi.org/10.1016/s1474-6670(17)31472-6.

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3

Zhang, Zhen, and Andrea Serrani. "The linear periodic output regulation problem." Systems & Control Letters 55, no. 7 (July 2006): 518–29. http://dx.doi.org/10.1016/j.sysconle.2005.11.002.

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Ichikawa, A. "Tracking and Regulation of Periodic Systems." IFAC Proceedings Volumes 22, no. 4 (June 1989): 283–88. http://dx.doi.org/10.1016/s1474-6670(17)53558-2.

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Kastner, Daniel L. "Hereditary Periodic Fever Syndromes." Hematology 2005, no. 1 (January 1, 2005): 74–81. http://dx.doi.org/10.1182/asheducation-2005.1.74.

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Abstract The hereditary periodic fevers are a group of Mendelian disorders characterized by seemingly unprovoked fever and localized inflammation. Recent data indicate that these illnesses represent inborn errors in the regulation of innate immunity. Pyrin, the protein mutated in familial Mediterranean fever, defines an N-terminal domain found in a large family of proteins involved in inflammation and apoptosis. Through this domain pyrin may play a role in the regulation of interleukin (IL)-1β, nuclear factor (NF)-κB, and leukocyte apoptosis. Cryopyrin/NALP3, another protein in this family, is mutated in three other hereditary febrile syndromes and participates in the inflammasome, a newly recognized macromolecular complex crucial to IL-1β activation. Somewhat unexpectedly, mutations in the 55 kDa receptor for tumor necrosis factor also give rise to a dominantly inherited periodic fever syndrome, rather than immunodeficiency, a finding that has stimulated important investigations into both pathogenesis and treatment. Finally, the discovery of the genetic basis of the hyperimmunoglobulinemia D with periodic fever syndrome suggests an as yet incompletely understood connection between the mevalonate pathway and the regulation of cytokine production. These insights extend our understanding of the regulation of innate immunity in man, while providing the conceptual basis for the rational design of targeted therapies, both for the hereditary periodic fevers themselves and other inflammatory disorders as well.

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BYATT, IAN. "Water Regulation: The Periodic Review - A Response." Fiscal Studies 15, no. 2 (May 1994): 95–97. http://dx.doi.org/10.1111/j.1475-5890.1994.tb00199.x.

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Paunonen, L., and S. Pohjolainen. "Periodic output regulation for distributed parameter systems." Mathematics of Control, Signals, and Systems 24, no. 4 (June 26, 2012): 403–41. http://dx.doi.org/10.1007/s00498-012-0087-x.

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Paunonen, Lassi. "Robust Output Regulation for Continuous-Time Periodic Systems." IEEE Transactions on Automatic Control 62, no. 9 (September 2017): 4363–75. http://dx.doi.org/10.1109/tac.2017.2654968.

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Liang, Wenwei, Chunhui Zhu, Feng Liu, Weiding Cui, Qing Wang, Zhefeng Chen, Qijia Zhou, Shun Xu, Chenjun Zhai, and Weimin Fan. "Integrin β1 Gene Therapy Enhances in Vitro Creation of Tissue-Engineered Cartilage Under Periodic Mechanical Stress." Cellular Physiology and Biochemistry 37, no. 4 (2015): 1301–14. http://dx.doi.org/10.1159/000430253.

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Background/Aims: Periodic mechanical stress activates integrin β1-initiated signal pathways to promote chondrocyte proliferation and matrix synthesis. Integrin β1 overexpression has been demonstrated to play important roles in improving the activities and functions of several non-chondrocytic cell types. Therefore, in the current study, we evaluated the effects of integrin β1 up-regulation on periodic mechanical stress-induced chondrocyte proliferation, matrix synthesis and ERK1/2 phosphorylation in chondrocyte monolayer culture, and evaluated the quality of tissue-engineered cartilage constructed in vitro under periodic mechanical stress combined with integrin β1 up-regulation. Methods and Results: Our results revealed that under periodic mechanical stress, pre-treatment with integrin β1-wild type vector significantly enhanced chondrocyte proliferation and matrix synthesis and promoted ERK1/2 phosphorylation in comparison to mock transfectants. Furthermore, when chondrocytes were seeded in PLGA scaffolds, more accumulated GAG and type II collagen tissue were detected after Lv-integrin β1 transfection compared with sham controls exposed to periodic mechanical stress. In contrast, in the Lv-shRNA-integrin β1 group, the opposite results were observed. Conclusion: Our findings collectively suggest that in addition to periodic mechanical stress, integrin β1 up-regulation in chondrocytes could further improve the quality of tissue-engineered cartilage.

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Giedrewicz-Niewińska, Aneta, and Łukasz Niewiński. "Kryteria oceny okresowej nauczycieli akademickich – wybrane zagadnienia." Radca Prawny, no. 4 (41) (February 10, 2025): 57–67. https://doi.org/10.4467/23921943rp.24.040.21192.

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The higher education reform and the associated new regulations keep the issue of periodic evaluation of academic staff relevant. The practice of conducting the first periodic appraisals based on the new regulation also confirms this. For example, doubts may arise about how to apply the principles for evaluating disciplines to the evaluation of academic teachers or heads of departments. The experience of US universities offers valuable insights into these matters. Attention should also focus on the system of academic staff evaluation by students, which raises many practical questions. The current legal regulations for evaluating academic teachers neither improve the state of science nor ensure its development as expected by society. They also fail to guarantee a high level of education for students and doctoral candidates.

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Stol, Karl, and Mark Balas. "Full-State Feedback Control of a Variable-Speed Wind Turbine: A Comparison of Periodic and Constant Gains." Journal of Solar Energy Engineering 123, no. 4 (July 1, 2001): 319–26. http://dx.doi.org/10.1115/1.1412237.

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An investigation of the performance of a model-based periodic gain controller is presented for a two-bladed, variable-speed, horizontal-axis wind turbine. Performance is based on speed regulation using full-span collective blade pitch. The turbine is modeled with five degrees-of-freedom; tower fore-aft bending, nacelle yaw, rotor position, and flapwise bending of each blade. An attempt is made to quantify what model degrees-of-freedom make the system most periodic, using Floquet modal properties. This justifies the inclusion of yaw motion in the model. Optimal control ideas are adopted in the design of both periodic and constant gain full-state feedback controllers, based on a linearized periodic model. Upon comparison, no significant difference in performance is observed between the two types of control in speed regulation.

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12

McIntosh, E. M., R. W. Ord, and R. K. Storms. "Transcriptional regulation of the cell cycle-dependent thymidylate synthase gene of Saccharomyces cerevisiae." Molecular and Cellular Biology 8, no. 11 (November 1988): 4616–24. http://dx.doi.org/10.1128/mcb.8.11.4616-4624.1988.

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We have previously shown that transcript levels expressed from the yeast TMP1 gene fluctuate periodically during the yeast cell cycle. However, it was not known whether periodic expression resulted from a regulatory mechanism acting at the level of transcription or a regulatory mechanism acting at the level of cell cycle stage-dependent changes in the stability of the TMP1 transcript. In this report we now show that the periodic expression of TMP1 transcript is primarily controlled at the level of its transcription by sequences which are upstream of its transcription initiation sites. We also localized the upstream sequences necessary for periodic transcription to a 150-base-pair region and show that this region encodes an element(s) with the properties of a periodic upstream activating sequence. The regulatory region defined in this study apparently does not contain consensus sequences similar to those reported for the cell cycle-regulated HO endonuclease or for the histone H2A and H2B genes of Saccharomyces cerevisiae.

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McIntosh, E. M., R. W. Ord, and R. K. Storms. "Transcriptional regulation of the cell cycle-dependent thymidylate synthase gene of Saccharomyces cerevisiae." Molecular and Cellular Biology 8, no. 11 (November 1988): 4616–24. http://dx.doi.org/10.1128/mcb.8.11.4616.

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We have previously shown that transcript levels expressed from the yeast TMP1 gene fluctuate periodically during the yeast cell cycle. However, it was not known whether periodic expression resulted from a regulatory mechanism acting at the level of transcription or a regulatory mechanism acting at the level of cell cycle stage-dependent changes in the stability of the TMP1 transcript. In this report we now show that the periodic expression of TMP1 transcript is primarily controlled at the level of its transcription by sequences which are upstream of its transcription initiation sites. We also localized the upstream sequences necessary for periodic transcription to a 150-base-pair region and show that this region encodes an element(s) with the properties of a periodic upstream activating sequence. The regulatory region defined in this study apparently does not contain consensus sequences similar to those reported for the cell cycle-regulated HO endonuclease or for the histone H2A and H2B genes of Saccharomyces cerevisiae.

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14

Suseto, Al Ikhsan Bayu, Edi Saputra, and Anggi Ahmad Talib. "REGULATION OF SINGLE-ORGAN NIGHTLIFE IN TANGGAMUS REGENCY THROUGH REGIONAL REGULATION NUMBER 05 OF 2017 CONCERNING THE REGULATION OF PUBLIC ENTERTAINMENT." European Journal of Learning on History and Social Sciences 1, no. 8 (August 4, 2024): 22–28. http://dx.doi.org/10.61796/ejlhss.v1i8.817.

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This article discusses the regulation of single-organ nightlife in Tanggamus Regency through the implementation of Regional Regulation Number 05 of 2017 concerning Public Entertainment Regulation. This study aims to evaluate the effectiveness of these regulations in overcoming social and legal problems arising from nightlife. Single-organ nightlife in Tanggamus often causes disturbances of public order, disturbing noise, and even criminal acts such as drug abuse and fights. To overcome this problem, the Tanggamus Regency Government issued a Regional Regulation that aims to order and regulate entertainment activities tonight. The research method used is a qualitative method with a descriptive approach. The data was collected through in-depth interviews with various related parties, including nightlife business actors, law enforcement officials, and the surrounding community. In addition, document analysis was carried out to understand the content and context of Regional Regulation Number 05 of 2017. The results of the study show that even though the regulation has been implemented, the level of legal awareness among the public and nightlife business actors is still low. Many business actors have not complied with existing regulations, such as operating beyond the predetermined time limit, noise levels that exceed the threshold, and the absence of supervision of illegal activities that occur in their premises. This low legal awareness is caused by several factors, including the lack of socialization and education about the importance of complying with this regulation. Socialization carried out by local governments often does not reach all levels of society and nightlife business actors, so information about this regulation is not spread evenly. In addition, law enforcement that is not strict is also a factor causing low compliance with regulations. Law enforcement officials often compromise on violations that occur, both due to pressure from certain parties and due to a lack of resources to carry out effective law enforcement. Additional measures are needed to increase the effectiveness of law enforcement against these regulations. These measures include increasing socialization and legal education, as well as stricter and more consistent law enforcement. In addition, there is a need for periodic evaluations of the effectiveness of these regulations and adjustments to law enforcement strategies in accordance with conditions and needs in the field. Thus, it is hoped that this regulation can be more effective in regulating single-organ nightlife in Tanggamus Regency and improving order and environmental security.

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15

Churilov, Alexander, Alexander Medvedev, and Alexander Shepeljavyi. "PERIODIC MODES IN A MATHEMATICAL MODEL OF TESTOSTERONE REGULATION." IFAC Proceedings Volumes 40, no. 14 (2007): 234–39. http://dx.doi.org/10.3182/20070829-3-ru-4912.00040.

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16

Astolfi, Daniele, Laurent Praly, and Lorenzo Marconi. "Nonlinear robust periodic output regulation of minimum phase systems." Mathematics of Control, Signals, and Systems 34, no. 1 (October 26, 2021): 129–84. http://dx.doi.org/10.1007/s00498-021-00307-w.

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Astolfi, Daniele, Laurent Praly, and Lorenzo Marconi. "Harmonic internal models for structurally robust periodic output regulation." Systems & Control Letters 161 (March 2022): 105154. http://dx.doi.org/10.1016/j.sysconle.2022.105154.

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18

Zhen Zhang and A. Serrani. "Adaptive Robust Output Regulation of Uncertain Linear Periodic Systems." IEEE Transactions on Automatic Control 54, no. 2 (February 2009): 266–78. http://dx.doi.org/10.1109/tac.2008.2010891.

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19

Giorno, Virginia, and Amelia G. Nobile. "Restricted Gompertz-Type Diffusion Processes with Periodic Regulation Functions." Mathematics 7, no. 6 (June 18, 2019): 555. http://dx.doi.org/10.3390/math7060555.

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We consider two different time-inhomogeneous diffusion processes useful to model the evolution of a population in a random environment. The first is a Gompertz-type diffusion process with time-dependent growth intensity, carrying capacity and noise intensity, whose conditional median coincides with the deterministic solution. The second is a shifted-restricted Gompertz-type diffusion process with a reflecting condition in zero state and with time-dependent regulation functions. For both processes, we analyze the transient and the asymptotic behavior of the transition probability density functions and their conditional moments. Particular attention is dedicated to the first-passage time, by deriving some closed form for its density through special boundaries. Finally, special cases of periodic regulation functions are discussed.

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20

Lucibello, P. "Output Regulation in a Neighbourhood of a Periodic Orbit." IFAC Proceedings Volumes 26, no. 2 (July 1993): 279–81. http://dx.doi.org/10.1016/s1474-6670(17)49127-0.

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21

Deutscher, Joachim, and Jakob Gabriel. "Periodic output regulation for general linear heterodirectional hyperbolic systems." Automatica 103 (May 2019): 208–16. http://dx.doi.org/10.1016/j.automatica.2019.02.006.

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22

Liu, DW, and JH Thomas. "Regulation of a periodic motor program in C. elegans." Journal of Neuroscience 14, no. 4 (April 1, 1994): 1953–62. http://dx.doi.org/10.1523/jneurosci.14-04-01953.1994.

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23

Colaneri, Patrizio. "Zero-error regulation of discrete-time linear periodic systems." Systems & Control Letters 15, no. 2 (August 1990): 161–67. http://dx.doi.org/10.1016/0167-6911(90)90010-r.

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24

Yuan, Meichen, Junlin Qu, Weirong Hong, and Pu Li. "Reconciling periodic rhythms of large-scale biological networks by optimal control." Royal Society Open Science 7, no. 1 (January 2020): 191698. http://dx.doi.org/10.1098/rsos.191698.

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Periodic rhythms are ubiquitous phenomena that illuminate the underlying mechanism of cyclic activities in biological systems, which can be represented by cyclic attractors of the related biological network. Disorders of periodic rhythms are detrimental to the natural behaviours of living organisms. Previous studies have shown that the state transition from one to another attractor can be accomplished by regulating external signals. However, most of these studies until now have mainly focused on point attractors while ignoring cyclic ones. The aim of this study is to investigate an approach for reconciling abnormal periodic rhythms, such as diminished circadian amplitude and phase delay, to the regular rhythms of complex biological networks. For this purpose, we formulate and solve a mixed-integer nonlinear dynamic optimization problem simultaneously to identify regulation variables and to determine optimal control strategies for state transition and adjustment of periodic rhythms. Numerical experiments are implemented in three examples including a chaotic system, a mammalian circadian rhythm system and a gastric cancer gene regulatory network. The results show that regulating a small number of biochemical molecules in the network is sufficient to successfully drive the system to the target cyclic attractor by implementing an optimal control strategy.

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Agustini, Rina Tri. "EVALUASI PEMERIKSAAN JENTIK BERKALA RUMAH WARGA DI WILAYAH PUSKESMAS TANAH KALIKEDINDING SURABAYA." Jurnal PROMKES 3, no. 2 (May 20, 2017): 195. http://dx.doi.org/10.20473/jpk.v3.i2.2015.195-205.

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During of January 2015 Dengue Hemorrhagic Fever (DHF) took place in 37 County city in East Java province, which the number of cases were 3136 and mortality rate were 52 cases. Surabaya reached 59 cases of DHF. The number of Larva Free Index in Tanah Kalikedinding Public Health Center bas around 86–88.7% in 2015, so haven’t reached the specified target which is 95%. One of the activities conducted to improve Larve Free Index was performing Periodic Larva Inspection of houses. Therefore, need to evaluation the implementation of Periodic Larva Inspection of houses included implementer, activities, time of implementation, reporting, and instrument of Periodic Larva Inspection. The Research design observational with study evaluation by descriptive.Technique of collecting data were included interviews, and documents collected. Analyze data by compared data obtained with the existing regulations and guidelines. Evaluation of implementer were in accordance with the regulation. However, if possible have to do advocacy for human resources addition from outside the posyandu cadres and dasawisma groups. Activities aspect underway in accordance with the guidelines. Time of implementation by Larva Monitoring Mother appropriate to standard, while it by Public Health Center offi cers more routine because it is adapted to conditions.Reporting aspect was in accordance with the regulation. Instruments that carried when implementation were accordingly. However, need to use Larva Card in each houses/buildings to facilitate the Inspection and data collecting. In addition, can be apply the Larva Free Village Contest to motivate cadres and citizens.Keywords: DHF, evaluation, larva, Periodic Larva Inspection.

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Sun, Kaibiao, Shan Liu, Andrzej Kasperski, and Yuan Tian. "Dynamics Analysis and Biomass Productivity Optimisation of a Microbial Cultivation Process through Substrate Regulation." Discrete Dynamics in Nature and Society 2016 (2016): 1–13. http://dx.doi.org/10.1155/2016/3685941.

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A microbial cultivation process model with variable biomass yield, control of substrate concentration, and biomass recycle is formulated, where the biochemical kinetics follows an extension of the Monod and Contois models. Control of substrate concentration allows for indirect monitoring of biomass and dissolved oxygen concentrations and consequently obtaining high yield and productivity of biomass. Dynamics analysis of the proposed model is carried out and the existence of order-1 periodic solution is deduced with a formulation of the period, which provides a theoretical possibility to convert the state-dependent control to a periodic one while keeping the dynamics unchanged. Moreover, the stability of the order-1 periodic solution is verified by a geometric method. The stability ensures a certain robustness of the adopted control; that is, even with an inaccurately detected substrate concentration or a deviation, the system will be always stable at the order-1 periodic solution under the control. The simulations are carried out to complement the theoretical results and optimisation of the biomass productivity is presented.

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Romadhon, Desi Dwiyanti, and Ida Bagus Nyoman Sukadana. "ANALISIS PERHITUNGAN, PENYETORAN, PELAPORAN DAN PENCATATAN PPN PADA PT XX TAHUN 2021." E-Jurnal Akuntansi TSM 3, no. 2 (August 25, 2023): 511–24. http://dx.doi.org/10.34208/ejatsm.v3i2.2171.

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This research aims to analyze the implementation calculation, depositing, reporting, and recording of VAT on XX company in 2021 It also explores the suitability with Regulations Number 42 Year 2009, Finance Minister Regulation Number 242/PMK.03/2014, Finance Minister Regulation Number 63/PMK.03/2021 and principle of general tax accounting. This analysis is carried out using qualitative descriptive methods, which collect and analyze the situation of the subject or object in an institutional form, based on the evidence and facts of the object of study. Data used includes periodic VAT returns for 2021, electronic receipts for 2021, input and output tax invoices for 2021, and recording journals for 2021. The results of this research showed that XX Company calculated, deposited, reported, and recorded VAT in accordance with Finance Minister Regulation Number 242/PMK.03/2014, Finance Minister Regulation Number 63/PMK.03/2021 and principle of generally tax accounting.

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Tsuruoka, Hidenobu, and Hiromitsu Ohmori. "Adaptive Output Regulation for Nonlinear Systems with Unknown Periodic Disturbances." IEEJ Transactions on Industry Applications 123, no. 10 (2003): 1104–10. http://dx.doi.org/10.1541/ieejias.123.1104.

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29

Dewell, Larry D., and Jason L. Speyer. "Fuel-Optimal Periodic Control and Regulation in Constrained Hypersonic Flight." Journal of Guidance, Control, and Dynamics 20, no. 5 (September 1997): 923–32. http://dx.doi.org/10.2514/2.4136.

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30

Psiaki, Mark L. "Magnetic Torquer Attitude Control via Asymptotic Periodic Linear Quadratic Regulation." Journal of Guidance, Control, and Dynamics 24, no. 2 (March 2001): 386–94. http://dx.doi.org/10.2514/2.4723.

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31

Stagner, J. I., and E. Samols. "Role of intrapancreatic ganglia in regulation of periodic insular secretions." American Journal of Physiology-Endocrinology and Metabolism 248, no. 5 (May 1, 1985): E522—E530. http://dx.doi.org/10.1152/ajpendo.1985.248.5.e522.

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The regulatory system responsible for insulin oscillations from the in vitro pancreas is unknown. To test the hypothesis that intrapancreatic ganglia are the pacemaker or driver of the oscillations, combined nicotinic, muscarinic, and adrenergic antagonists were infused. Combined muscarinic, alpha- and beta-adrenergic, and presynaptic nicotinic receptor blockade (beta-bungarotoxin) was without effect on oscillations. The infusion of the postsynaptic nicotinic receptor antagonists, hexamethonium, alpha-bungarotoxin (ATX), or curarine, significantly altered the preinfusion oscillatory pattern of insulin release by reducing the period. Nicotine-stimulated insulin release was inhibited by ATX on a background of atropine, phentolamine, and beta-bungarotoxin. Propranolol decreased nicotine-stimulated insulin release, which was further reduced by ATX. These data support the theory that nicotinic receptors may be present pre- and postsynaptically at the ganglionic level and presynaptically on sympathetic nerve axons. We propose that ganglionic nicotinic receptors may be regulatory and that ganglia may serve as the pacemaker to regulate pancreatic hormone oscillations.

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Iyer, A., and S. N. Singh. "Nonlinear Asymptotic Regulation of Space Station Accommodating Periodic Aerodynamic Disturbance." IFAC Proceedings Volumes 26, no. 2 (July 1993): 937–40. http://dx.doi.org/10.1016/s1474-6670(17)48872-0.

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Colaneri, P. "Discrete-Time Linear Periodic Systems: Stabilization and Zero Error Regulation." IFAC Proceedings Volumes 23, no. 8 (August 1990): 193–98. http://dx.doi.org/10.1016/s1474-6670(17)52094-7.

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Zheng, Shiqi, Peng Shi, Ramesh K. Agarwal, and Chee Peng Lim. "Periodic event-triggered output regulation for linear multi-agent systems." Automatica 122 (December 2020): 109223. http://dx.doi.org/10.1016/j.automatica.2020.109223.

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GRASSELLI, OSVALDO MARIA, and SAURO LONGHI. "Robust tracking and regulation of linear periodic discrete-time systems." International Journal of Control 54, no. 3 (September 1991): 613–33. http://dx.doi.org/10.1080/00207179108934179.

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Gao, Gongming, Haibo Li, Yongjing Huang, Jianjian Yin, Yuqing Jiang, Nanwei Xu, Dong Zhou, Luming Nong, and Kewei Ren. "Periodic Mechanical Stress Induces Extracellular Matrix Expression and Migration of Rat Nucleus Pulposus Cells Through Src-GIT1-ERK1/2 Signaling Pathway." Cellular Physiology and Biochemistry 50, no. 4 (2018): 1510–21. http://dx.doi.org/10.1159/000494650.

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Background/Aims: Periodic mechanical stress has been shown to promote extracellular matrix (ECM) synthesis and cell migration of nucleus pulposus (NP) cells, however, the mechanisms need to be fully elucidated. The present study aimed to investigate the signal transduction pathway in the regulation of NP cells under periodic mechanical stress. Methods: Primary rat NP cells were isolated and seeded on glass slides, and then treated in our self-developed periodic stress field culture system. To further explore the mechanisms, data were analyzed by scratch-healing assay, quantitative reverse transcription polymerase chain reaction (RT-qPCR) analysis, western blotting, and co-immunoprecipitation assay. Results: Under periodic mechanical stress, the mRNA expression of ECM collagen 2A1 (Col2A1) and aggrecan, and migration of NP cells were significantly increased (P < 0.05 for each), associating with increases in the phosphorylation of Src, GIT1, and ERK1/2 (P < 0.05 for each). Pretreatment with the Src inhibitor PP2 reduced periodic mechanical stress-induced ECM synthesis and cell migration of NP cells (P < 0.05 for each), while the phosphorylation of GIT1 and ERK1/2 were inhibited. ECM synthesis, cell migration, and phosphorylation of ERK1/2 were inhibited after pretreatment with the small interfering RNA for GIT1 in NP cells under periodic mechanical stress (P < 0.05 for each), whereas the phosphorylation of Src was not affected. Pretreatment with the ERK1/2 inhibitor PD98059 reduced periodic mechanical stress-induced ECM synthesis and cell migration of NP cells (P < 0.05 for each). Co-immunoprecipitation assay showed that there was a direct interaction between Src and GIT1 and between GIT1 and ERK1/2. Conclusion: In conclusion, periodic mechanical stress induced ECM expression and migration of NP cells via Src-GIT1-ERK1/2 signaling pathway, playing an important role in regulation of NP cells.

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Bayly, P. V., and K. S. Wilson. "Analysis of unstable modes distinguishes mathematical models of flagellar motion." Journal of The Royal Society Interface 12, no. 106 (May 2015): 20150124. http://dx.doi.org/10.1098/rsif.2015.0124.

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The mechanisms underlying the coordinated beating of cilia and flagella remain incompletely understood despite the fundamental importance of these organelles. The axoneme (the cytoskeletal structure of cilia and flagella) consists of microtubule doublets connected by passive and active elements. The motor protein dynein is known to drive active bending, but dynein activity must be regulated to generate oscillatory, propulsive waveforms. Mathematical models of flagellar motion generate quantitative predictions that can be analysed to test hypotheses concerning dynein regulation. One approach has been to seek periodic solutions to the linearized equations of motion. However, models may simultaneously exhibit both periodic and unstable modes. Here, we investigate the emergence and coexistence of unstable and periodic modes in three mathematical models of flagellar motion, each based on a different dynein regulation hypothesis: (i) sliding control; (ii) curvature control and (iii) control by interdoublet separation (the ‘geometric clutch’ (GC)). The unstable modes predicted by each model are used to critically evaluate the underlying hypothesis. In particular, models of flagella with ‘sliding-controlled’ dynein activity admit unstable modes with non-propulsive, retrograde (tip-to-base) propagation, sometimes at the same parameter values that lead to periodic, propulsive modes. In the presence of these retrograde unstable modes, stable or periodic modes have little influence. In contrast, unstable modes of the GC model exhibit switching at the base and propulsive base-to-tip propagation.

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Shi, Wentao, Zhe Wang, Lu Bian, Yiqing Wu, Mei HuiYa, Yanjun Zhou, Zhijian Zhang, Qing Wang, Peng Zhao, and Xiaojie Lu. "Periodic Heat Stress Licenses EMSC Differentiation into Osteoblasts via YAP Signaling Pathway Activation." Stem Cells International 2022 (March 18, 2022): 1–14. http://dx.doi.org/10.1155/2022/3715471.

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Background. The repair and regeneration of large bone defects represent highly challenging tasks in bone tissue engineering. Although recent studies have shown that osteogenesis is stimulated by periodic heat stress, the thermal regulation of osteogenic differentiation in ectomesenchymal stem cells (EMSCs) is not well studied. Methods and Results. In this study, the direct effects of periodic heat stress on the differentiation of EMSCs into osteoblasts were investigated. EMSCs derived from rat nasal respiratory mucosa were seeded onto culture plates, followed by 1 h of heat stress at 41°C every 7 days during osteogenic differentiation. Based on the results of the present study, periodic heating increases alkaline phosphatase (ALP) activity, upregulates osteogenic-related proteins, and promotes EMSC mineralization. In particular, increased YAP nuclear translocation and YAP knockdown inhibited osteogenic differentiation induced by heat stress. Furthermore, the expression and activity of transglutaminase 2 (TG2) were significantly increased after YAP nuclear translocation. Conclusion. Together, these results indicate that YAP plays a key role in regulating cellular proteostasis under stressful cellular conditions by modulating the TG2 response.

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Anggasta, Giovani, Afifah Kusumadara, and Hanif Nur Widhiyanti. "REGULATION OF LOSS-INDUCING CRYPTO ASSET INVESTMENTS: CHALLENGES IN REGULATION, PROTECTION AND SUPERVISION." International Journal of Business, Law, and Education 4, no. 2 (October 9, 2023): 868–81. http://dx.doi.org/10.56442/ijble.v4i2.255.

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Cryptocurrency has become evidence of the rapid growth of the digital economy. This phenomenon has left countries worldwide in a dilemma regarding the legal status of cryptocurrencies. Specifically in Indonesia, cryptocurrency is regulated in a limited manner, creating a gap in legal protection for investors. This research employs a normative research method with a legislative and conceptual approach. The findings of this research indicate that Indonesia tends to position cryptocurrencies in a "limited" capacity, restricting them to being considered investments rather than currency. Nevertheless, due to the legal gaps, there is a need to establish standardized, periodic, and embedded security measures overseen by Bappebti to ensure maximum protection provided by every cryptocurrency wallet service provider. Additionally, it should be mandatory for every service provider to comprehensively insure digital assets to offer financial protection to individuals.

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Maryanto, Lilik, Muhammad Masduki Ali Choer, and Zulkipli Lessy. "Analisis Faktor Sosial Penyebab Ketidakpatuhan Mahasantri di Pesantren Salaf-Inklusif: Implikasi untuk Pengelolaan Kebijakan Pendidikan Islam." Journal of Social Movements 1, no. 2 (July 31, 2024): 110–21. https://doi.org/10.62491/jsm.v1i2.2024.24.

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This study investigates the social factors contributing to non-compliance among students in salaf-inclusive Islamic boarding schools, with a focus on Al-Munawwir Islamic Boarding School, Komplek L, Bantul, Yogyakarta. Employing a sociological approach, the study collected data through observations, questionnaires, interviews, and literature review, analyzed using data reduction, data display, and interpretation techniques. Triangulation was applied to ensure data credibility. Findings reveal that while most students understand the regulations, the lack of periodic socialization by management contributes to non-compliance. The primary reasons for non-compliance are psychological factors such as laziness, fatigue, and external priorities conflicting with mandatory school hours. A smaller portion of students reported non-compliance due to perceived misalignment between regulations and personal beliefs. Recommendations include strengthening regulation socialization, enhancing time management motivation, and implementing effective sanctions. These findings aim to inform policymakers and contribute to academic discourse on regulation compliance in educational institutions.

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Christhoper Stephanus, Edward, and Stevany Salim. "PELAKSANAAN KENAIKAN UPAH BERKALA DIHUBUNGKAN DENGAN PERUNDANG-UNDANGAN KETENAKERJAAN." Kertha Semaya : Journal Ilmu Hukum 10, no. 3 (February 12, 2022): 641. http://dx.doi.org/10.24843/ks.2022.v10.i03.p14.

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Tujuan dari studi ini ialah untuk mengkaji kepastian hukum dalam hal kenaikan upah berkala, dimana kenaikan upah berkala belum dijelaskan secara mendetail dan mengingat bahwa upah juga merupakan hak pekerja yang penting untuk kelangsungan hidup pekerja dan juga untuk menjaga SDM yang terdapat dalam perusahaan. Studi ini menggunakan metode hukum empiris yang berasal dari penelitian lapangan dengan perbandingan peraturan dan peristiwa yang berlaku dibandingkan dengan penelitian hukum. Hasil studi ini menunjukkan bahwa mengenai kenaikan upah berkala dalam perusahaan swasta belum ada suatu hukum ataupun perundang-undangan yang mengatur bagaimana tata cara penyusunan kenaikan upah berkala yang paling sesuai untuk kelangsungan hidup pekerja / karyawan dan keberlangsungan perusahaan. The purpose of this study is to examine legal certainty in terms of periodic wage increases, where periodic wage increases have not been explained in detail and considering that wages are also an important worker right for the survival of workers and also to maintain human resources in the company. This study uses empirical legal methods derived from field research with a comparison of applicable regulations and events compared to legal research. The results of this study indicate that regarding periodic wage increases in private companies there is no law or regulation that regulates the most appropriate procedure for the preparation of periodic wage increases for the survival of workers/employees and the sustainability of the company.

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Kelliher, Christina M., Matthew W. Foster, Francis C. Motta, Anastasia Deckard, Erik J. Soderblom, M. Arthur Moseley, and Steven B. Haase. "Layers of regulation of cell-cycle gene expression in the budding yeast Saccharomyces cerevisiae." Molecular Biology of the Cell 29, no. 22 (November 2018): 2644–55. http://dx.doi.org/10.1091/mbc.e18-04-0255.

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In the budding yeast Saccharomyces cerevisiae, transcription factors (TFs) regulate the periodic expression of many genes during the cell cycle, including gene products required for progression through cell-cycle events. Experimental evidence coupled with quantitative models suggests that a network of interconnected TFs is capable of regulating periodic genes over the cell cycle. Importantly, these dynamical models were built on transcriptomics data and assumed that TF protein levels and activity are directly correlated with mRNA abundance. To ask whether TF transcripts match protein expression levels as cells progress through the cell cycle, we applied a multiplexed targeted mass spectrometry approach (parallel reaction monitoring) to synchronized populations of cells. We found that protein expression of many TFs and cell-cycle regulators closely followed their respective mRNA transcript dynamics in cycling wild-type cells. Discordant mRNA/protein expression dynamics was also observed for a subset of cell-cycle TFs and for proteins targeted for degradation by E3 ubiquitin ligase complexes such as SCF (Skp1/Cul1/F-box) and APC/C (anaphase-promoting complex/cyclosome). We further profiled mutant cells lacking B-type cyclin/CDK activity ( clb1-6) where oscillations in ubiquitin ligase activity, cyclin/CDKs, and cell-cycle progression are halted. We found that a number of proteins were no longer periodically degraded in clb1-6 mutants compared with wild type, highlighting the importance of posttranscriptional regulation. Finally, the TF complexes responsible for activating G1/S transcription (SBF and MBF) were more constitutively expressed at the protein level than at periodic mRNA expression levels in both wild-type and mutant cells. This comprehensive investigation of cell-cycle regulators reveals that multiple layers of regulation (transcription, protein stability, and proteasome targeting) affect protein expression dynamics during the cell cycle.

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Barua, B., D. A. Winkelmann, H. D. White, and S. E. Hitchcock-DeGregori. "Regulation of actin-myosin interaction by conserved periodic sites of tropomyosin." Proceedings of the National Academy of Sciences 109, no. 45 (October 22, 2012): 18425–30. http://dx.doi.org/10.1073/pnas.1212754109.

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Nadim, Farzan, Yair Manor, Michael P. Nusbaum, and Eve Marder. "Frequency Regulation of a Slow Rhythm by a Fast Periodic Input." Journal of Neuroscience 18, no. 13 (July 1, 1998): 5053–67. http://dx.doi.org/10.1523/jneurosci.18-13-05053.1998.

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Trachana, Kalliopi, Lars Juhl Jensen, and Peer Bork. "Evolution and regulation of cellular periodic processes: a role for paralogues." EMBO reports 11, no. 3 (February 19, 2010): 233–38. http://dx.doi.org/10.1038/embor.2010.9.

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Nair, R. Vimala. "Periodic events and cell cycle regulation in the plasmodia ofPhysarum polycephalum." Journal of Biosciences 20, no. 1 (January 1995): 105–39. http://dx.doi.org/10.1007/bf02711585.

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Kawashima, Konosuke. "Queueing analysis for input regulation method employing periodic monitoring and control." European Journal of Operational Research 23, no. 1 (January 1986): 100–107. http://dx.doi.org/10.1016/0377-2217(86)90220-1.

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Abou Saleh, Anthony, Anton Rudenko, Stéphanie Reynaud, Florent Pigeon, Florence Garrelie, and Jean-Philippe Colombier. "Sub-100 nm 2D nanopatterning on a large scale by ultrafast laser energy regulation." Nanoscale 12, no. 12 (2020): 6609–16. http://dx.doi.org/10.1039/c9nr09625f.

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Zafitriani, Difanti Ameliananda, and Karimatul Khasanah. "Kepastian Hukum dalam Pelaksanaan Pengawasan Produk Bersertifikat Halal di Indonesia." el hisbah Journal of Islamic Economic Law 4, no. 1 (May 30, 2024): 13–26. https://doi.org/10.28918/elhisbah.v4i1.7551.

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The implementation of the guarantee of products that have been halal certified is a mandate from the Halal Product Guarantee Law. However, in reality, the technical implementation of periodic supervision of products that have been halal certified has not been specifically regulated in laws and regulations. Therefore, the principle of legal certainty that should be reflected in every regulation is suspected of not being optimally implemented in regulations that guarantee the halalness of halal certified products. This study aims to analyze legal instruments related to halal product guarantees in Indonesia, as well as to examine the legal implications that arise due to legal uncertainty in the technical regulation of supervision of halal certified products. The type of normative legal research with a statutory approach and a conceptual approach. The legal material analysis technique is carried out qualitatively by examining and interpreting laws and regulations, legal doctrines, and the results of theoretical studies to obtain systematic and logical legal arguments related to the regulation of guarantees and supervision of halal products in Indonesia. The results of the study show that halal product guarantee regulations in Indonesia still do not fully reflect the principle of legal certainty, especially regarding post-certification supervision mechanisms. The absence of technical regulations governing the implementation of such supervision has the potential to create legal loopholes and uncertainty in consumer protection and strengthening the halal product guarantee system.

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Zhou, Guo Peng, Shi Jie Cheng, Jin Hua Huang, and Di Liu. "Energy Storage Based Adaptive Control of Disturbed Load Interconnected Power Systems." Advanced Materials Research 732-733 (August 2013): 981–87. http://dx.doi.org/10.4028/www.scientific.net/amr.732-733.981.

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A simple interconnected power system with periodic load disturbance is considered, an energy storage based adaptive controller is proposed to output tracking and disturbance completely rejection for the system. Since the periodic load disturbance is uncertain with both amplitude and frequency, by constructing a new exosystem, the output tracking and disturbance rejection problem is solved with output regulation theory. By designing an internal model for the complicated system and introducing an appropriate transformation, the output regulation problem is changed into the stabilization problem of a new augmented system. With the help of adaptive control technique, the designed dynamic energy storage controller can solve stabilization problem of the augmented systems as well as the output tracking and disturbance rejection problem for the original system. Finally, the simulation results show the effectiveness of the proposed control strategy.

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Journal articles on the topic 'Periodic regulation'

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