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Journal articles on the topic 'Periodontal cells'

Author: Grafiati

Published: 15 June 2024

Last updated: 31 July 2025

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1

Nokhbehsaim, Marjan, Anna Damanaki, Andressa Vilas Boas Nogueira, et al. "Regulation of Ghrelin Receptor by Periodontal Bacteria In Vitro and In Vivo." Mediators of Inflammation 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/4916971.

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Ghrelin plays a major role in obesity-related diseases which have been shown to be associated with periodontitis. This study sought to analyze the expression of the functional receptor for ghrelin (GHS-R1a) in periodontal cells and tissues under microbial conditions in vitro and in vivo. The GHS-R1a expression in human periodontal cells challenged with the periodontopathogen Fusobacterium nucleatum, in gingival biopsies from periodontally healthy and diseased individuals, and from rats with and without ligature-induced periodontitis was analyzed by real-time PCR, immunocytochemistry, and immun

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Marjanović, D., Z. Anðelković, N. Videnović, et al. "MAST CELLS IN PERIODONT PERIODONTAL DISEASE DISEASE." Praxis medica 35, no. 2 (2007): 99–102. http://dx.doi.org/10.70949/pramed200702210m.

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&lt;p&gt;Periodontal disease is a chronic inflammatory disease that is largely attributable to infections with gram-negative bacteria and is characterised by both gingival inflammation and alveolar bone resorption. Beside macrophages, the second most common cells of the gingival inflammatory infiltrat are mast cells. Mast cells are heterogenous cell population which live from six months to one year. These cells are activated by differnt immunologic and non-immunologic signals. Activated mast cells can secrete a range of substances that regulate angiogenesis, tissue remodeling and wound

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3

Mancini, Leonardo, Adriano Fratini, and Enrico Marchetti. "Periodontal Regeneration." Encyclopedia 1, no. 1 (2021): 87–98. http://dx.doi.org/10.3390/encyclopedia1010011.

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Periodontal regeneration is a technique that aims to regenerate the damaged tissue around periodontally compromised teeth. The regenerative process aims to use scaffolds, cells, and growth factors to enhance biological activity.

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Fabila-Plata, Miriam Susana, and Rosa Diana Hernández Palacios. "Tratamiento de la enfermedad periodontal con células troncales de origen pulpar, en un adulto mayor. Caso clínico." Casos y Revisiones de Salud 3, no. 1 (2021): 32–39. http://dx.doi.org/10.22201/fesz.26831422e.2021.3.1.4.

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Introducción. La enfermedad periodontal (EP) es un padecimiento de tipo inflamatorio crónico y con frecuencia causa pérdida dental en los adultos mayores. Su tratamiento se orienta a la regeneración de los tejidos periodontales a través de la eliminación de los agentes infecciosos presentes en el periodonto y en la sustitución del hueso alveolar perdido. Caso clínico. Paciente femenina de 61 años de edad que acudió a consulta estomatológica por presentar movilidad dental. En la valoración bucal se observó enfermedad periodontal. Se realizaron las tres fases de la terapia periodontal con aplica

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Aditya, Vangara, and Kharidhi Laxman Vandana. "Management of endo-perio lesion with autologous stem cell therapy." Saudi Journal of Oral Sciences 11, no. 1 (2024): 54–59. http://dx.doi.org/10.4103/sjoralsci.sjoralsci_79_23.

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The objective of periodontal therapy is the regeneration of tooth-supporting tissues. Various treatment modalities, such as the use of bone grafting materials, guided tissue regeneration, and delivery of enamel matrix derivatives or growth factors, are applied with large variability in regenerative outcomes. However, a case report was done by utilization of autologous dental pulp stem cells and periodontal ligament stem cell niches in the treatment of bone loss associated with endodontically and periodontally involved teeth. An autologous periodontal ligament stem cells niche adherent to the r

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Nighojkar, Urvashi Rajeev, Dr Priya A. Lele, and Mudita Agrawal. "Scope of Stem Cells in Periodontal Regeneration." International Journal of Scientific Research 2, no. 5 (2012): 428–31. http://dx.doi.org/10.15373/22778179/may2013/145.

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7

Karunanithi Arulvizhi M, Arunagiri. "Stem Cells in Periodontal Regenerations - A Review." International Journal of Science and Research (IJSR) 13, no. 2 (2024): 589–94. http://dx.doi.org/10.21275/sr24206105401.

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8

Gonçalves, Gabriela Sumie Yaguinuma, Tayna Natsumi Takakura, Anderson Catelan, Rosalinda Tanuri Zaninotto Venturim, Carolina dos Santos Santinoni, and Christine Men Martins. "Tratar ou extrair? Tratamento de lesão endoperiodontal, um relato de caso clínico." ARCHIVES OF HEALTH INVESTIGATION 9, no. 6 (2020): 535–40. http://dx.doi.org/10.21270/archi.v9i6.4814.

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Introdução: Lesões endoperiodontais são lesões originadas de produtos inflamatórios encontrados tanto em periodonto quanto em polpa. Tais lesões podem se originar devido a uma infecção pulpar ou periodontal. Visando o prognóstico favorável, é imprescindível o conhecimento da etiologia, realização do correto diagnóstico e elaboração do plano de tratamento que envolve o tratamento endodôntico precedido do tratamento periodontal. Objetivo: O propósito do presente trabalho foi de relatar um caso clínico de lesão endoperiodontal e o tratamento realizado. Relato de caso clínico: Paciente gênero femi

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9

Song, In Seok, Yoon Sic Han, Joo-Hee Lee, Soyoun Um, Hui Young Kim, and Byoung Moo Seo. "Periodontal Ligament Stem Cells for Periodontal Regeneration." Current Oral Health Reports 2, no. 4 (2015): 236–44. http://dx.doi.org/10.1007/s40496-015-0060-0.

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10

Hosokawa, Yoshitaka, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki та Takashi Matsuo. "IL-4 Modulates CCL11 and CCL20 Productions from IL-1β-Stimulated Human Periodontal Ligament Cells". Cellular Physiology and Biochemistry 38, № 1 (2016): 153–59. http://dx.doi.org/10.1159/000438617.

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Background/Aims: IL-4 is a multifunctional cytokine that is related with the pathological conditions of periodontal disease. However, it is uncertain whether IL-4 could control T cells migration in periodontal lesions. The aim of this study was to examine the effects of IL-4 on CCL11, which is a Th2-type chemokine, and CCL20, which is related with Th17 cells migration, productions from human periodontal ligament cells (HPDLCs). Methods: CCL20 and CCL11 productions from HPDLCs were monitored by ELISA. Western blot analysis was performed to detect phosphorylations of signal transduction molecule

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11

Saito, A., E. Saito, M. Kawanami, and A. Shimada. "Healing in Transplanted Teeth with Periodontal Ligament Cultured In Vitro." Cell Transplantation 12, no. 5 (2003): 519–25. http://dx.doi.org/10.3727/000000003108747082.

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Regeneration of connective tissue attachment is the ultimate goal of periodontal therapy. It has been suggested that periodontal ligament cells possess the potential to create new connective tissue attachment. However, as cells from gingiva and alveolar bone occupy the root surface during initial wound healing, population by periodontal ligament cells is limited in vivo. We have been developing a new periodontal regeneration technique using in vitro tissue culture of periodontal ligament remaining on a periodontally involved root. The purpose of this study was to examine the periodontal healin

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12

Kramer, P. R., S. Nares, S. F. Kramer, D. Grogan, and M. Kaiser. "Mesenchymal Stem Cells Acquire Characteristics of Cells in the Periodontal Ligament in vitro." Journal of Dental Research 83, no. 1 (2004): 27–34. http://dx.doi.org/10.1177/154405910408300106.

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Mesenchymal stem cells differentiate into multiple types of cells derived from mesenchyme. Periodontal ligament cells are primarily derived from mesenchyme; thus, we expected mesenchymal stem cells to differentiate into periodontal ligament. Using a combination of immunohistochemistry and in situ hybridization on co-cultures of mesenchymal stem cells and periodontal ligament, we observed a significant increase in mesenchymal stem cells’ expression of osteocalcin and osteopontin and a significant decrease in expression of bone sialoprotein, characteristics of periodontal ligament in vivo. Incre

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Iwayama, Tomoaki, Hiromi Sakashita, Masahide Takedachi, and Shinya Murakami. "Periodontal tissue stem cells and mesenchymal stem cells in the periodontal ligament." Japanese Dental Science Review 58 (November 2022): 172–78. http://dx.doi.org/10.1016/j.jdsr.2022.04.001.

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14

Adel, Ghadeer M., Ahmed A. Khalil, and Ahmed A. Moustafa. "Stem Cell with a Peri-implant Defects." NeuroQuantology 20, no. 4 (2022): 466–68. http://dx.doi.org/10.14704/nq.2022.20.4.nq22288.

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Periodontal regeneration aims are restoring of the destructed bone, cementum and periodontal ligament. The new strategies of regeneration is very challenging, one of these strategies is tissue engineering, including stem cells and it's considered very promising solution. This paper aims to review the use of stem cells for the treatment of peri-implant defects. Nowadays, many types of mesenchymal stem cells (MSCs) have the ability of periodontal regeneration in animal studies. The bone marrow MSCs (BMMSCs), dental pulp stem cell (DPSC), periodontal ligament stem cells (PDLSCs), and gingival mes

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15

Sunkara, Sahithi, Sandhya Pavankumar, Trinath Kishore Damera та Durga Bhavani Kundrapu. "Estimation of the salivary levels of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1α in periodontitis patients with and without diabetes in comparison to systemically and periodontally healthy individuals". Journal of Indian Society of Periodontology 29, № 1 (2025): 73–79. https://doi.org/10.4103/jisp.jisp_251_24.

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Background: Early identification of periodontal disease, mainly in diabetic patients, is crucial for the prognosis and treatment planning. Biochemical signaling during periodontal disease involves the production of cytokines. Chemokines belong to the group of chemotactic cytokines that are able to activate and migrate a variety of cells, like bone cells and leukocytes, which stimulate inflammatory events. Chemotactic chemokines, monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-1 alpha (MIP-1α) are secreted by different types of cells. These salivary biomarkers mi

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Shaikh, Muhammad Saad, Zara Shahzad, Esraa Abdulgader Tash, Omer Sefvan Janjua, Muhammad Ikram Khan, and Muhammad Sohail Zafar. "Human Umbilical Cord Mesenchymal Stem Cells: Current Literature and Role in Periodontal Regeneration." Cells 11, no. 7 (2022): 1168. http://dx.doi.org/10.3390/cells11071168.

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Periodontal disease can cause irreversible damage to tooth-supporting tissues such as the root cementum, periodontal ligament, and alveolar bone, eventually leading to tooth loss. While standard periodontal treatments are usually helpful in reducing disease progression, they cannot repair or replace lost periodontal tissue. Periodontal regeneration has been demonstrated to be beneficial in treating intraosseous and furcation defects to varied degrees. Cell-based treatment for periodontal regeneration will become more efficient and predictable as tissue engineering and progenitor cell biology a

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Garna, Devy, Manmeet Kaur, Francis J. Hughes, and Mandeep Ghuman. "Comparison of the Expression of Periodontal Markers in Dental and Bone Marrow-derived Mesenchymal Stem Cells." Open Dentistry Journal 14, no. 1 (2020): 196–202. http://dx.doi.org/10.2174/1874210602014010196.

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Background: Periodontal ligament stem cells are a source of mesenchymal stem cells, but it is unclear whether their phenotype is distinct from mesenchymal stem cells derived from different tissues, such as those derived from bone marrow. Objective: To investigate the expression of the putative PDL markers asporin, periostin, nestin and cementum protein 1, by periodontal ligament stem cells both constitutively and during osteogenic differentiation when compared to bone marrow-derived mesenchymal stem cells, and dental pulp stem cells. Methods: The primary human periodontal ligament, bone marrow

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18

Chukkapalli, Sasanka S., and Tanmay P. Lele. "Periodontal cell mechanotransduction." Open Biology 8, no. 9 (2018): 180053. http://dx.doi.org/10.1098/rsob.180053.

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The periodontium is a structurally and functionally complex tissue that facilitates the anchorage of teeth in jaws. The periodontium consists of various cell types including stem cells, fibroblasts and epithelial cells. Cells of the periodontium are constantly exposed to mechanical stresses generated by biological processes such as the chewing motions of teeth, by flows generated by tongue motions and by forces generated by implants. Mechanical stresses modulate the function of cells in the periodontium, and may play a significant role in the development of periodontal disease. Here, we review

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Hendrawan, Reza Dony, Chiquita Prahasanti, Irma Josefina Savitri, and Padmini Hari. "Induced pluripotent stem cells in periodontal reconstructive therapy: A narrative review of pre-clinical studies." Dental Journal 56, no. 4 (2023): 280–86. http://dx.doi.org/10.20473/j.djmkg.v56.i4.p280-286.

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Background: Regenerative periodontal surgical therapy faces significant challenges due to the limited ability of the body to regenerate damaged periodontal tissue. One of the primary goals in regenerative periodontal therapy is regaining periodontal tissue attachment after destruction by periodontal disease. Currently, stem cells, harnessing three pivotal components—cells, biomaterials, and growth factors—are widely used in periodontal regeneration. Stem cells can be obtained from various sources, either by isolating cells from bone marrow, teeth, and muscles or through the somatic cell progra

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Koskinen Holm, Cecilia, Sara Rosendahl, Per-Arne Oldenborg та Pernilla Lundberg. "The expression of signal regulatory protein alpha (SIRPα) in periodontal cells and tissue". Acta Odontologica Scandinavica 83 (11 вересня 2024): 486–92. http://dx.doi.org/10.2340/aos.v83.41391.

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Signal regulatory protein alpha (SIRPα) is mainly expressed by cells of myeloid origin. This membrane glycoprotein is shown to be involved in regulation of different inflammatory conditions, such as colitis and arthritis. However, SIRPα has not been investigated in relationship to periodontitis, an inflammatory condition affecting the tooth supporting tissues. We aim to investigate if resident cells in the periodontium express SIRPα and whether a possible expression is affected by inflammatory conditions. Primary human keratinocytes, fibroblasts, periodontal ligament cells, and osteoblasts wer

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Bellei, Elisa, Emanuela Monari, Carlo Bertoldi, and Stefania Bergamini. "Proteomic Comparison between Periodontal Pocket Tissue and Other Oral Samples in Severe Periodontitis: The Meeting of Prospective Biomarkers." Sci 6, no. 4 (2024): 57. http://dx.doi.org/10.3390/sci6040057.

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Periodontitis is characterized by gingival regression, alveolar bone resorption and the development of deep periodontal pockets that, if left untreated, can lead to tooth loss. Currently, specific biomarkers are needed for the early, objective diagnosis, monitoring, and management of periodontal patients. In this proteomic study, periodontal pocket tissues from patients with severe periodontitis were analyzed in comparison to periodontally healthy sites with the aim of discovering distinctive protein targets. Gingival tissues were fragmented using a motorized mechanical method and mixture prot

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Pejcic, A., D. Kojovic, D. Mirkovic, and I. Minic. "Stem Cells for Periodontal Regeneration." Balkan Journal of Medical Genetics 16, no. 1 (2013): 7–11. http://dx.doi.org/10.2478/bjmg-2013-0012.

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Abstract Periodontal regeneration is considered to be biologically possible but clinically unpredictable. In periodontitis, inflammation manifests clinically as loss of supporting periodontal tissues and regeneration of damaged tissue is the main goal of treatment. For decades, periodontists have sought to repair the damage through a variety of surgical procedures, and use of grafting materials and growth factors, and of barrier membranes. Reports have emerged that demonstrate which populations of adult stem cells reside in the periodontal ligaments of humans and other animals. This opens the

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Sivaram G, Dr, and Dr R. Shri Nandhini Devi. "Stem Cells in Periodontal Regeneration." IOSR Journal of Dental and Medical Sciences 13, no. 9 (2014): 31–40. http://dx.doi.org/10.9790/0853-13963140.

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Bartold, P. Mark, Songtao Shi, and Stan Gronthos. "Stem cells and periodontal regeneration." Periodontology 2000 40, no. 1 (2006): 164–72. http://dx.doi.org/10.1111/j.1600-0757.2005.00139.x.

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Lin, N.-H., S. Gronthos, and PM Bartold. "Stem cells and periodontal regeneration." Australian Dental Journal 53, no. 2 (2008): 108–21. http://dx.doi.org/10.1111/j.1834-7819.2008.00019.x.

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Lund, Amy E. "PERIODONTAL LIGAMENT STEM CELLS ISOLATED." Journal of the American Dental Association 135, no. 9 (2004): 1236. http://dx.doi.org/10.14219/jada.archive.2004.0393.

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Sudhakar, Uma, JRanjit Kumar, and MSatya Narayana. "Stem Cells in Periodontal Therapy." SRM Journal of Research in Dental Sciences 3, no. 2 (2012): 145. http://dx.doi.org/10.4103/0976-433x.128064.

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Ohsugi, Yujin, Hiromi Niimi, Tsuyoshi Shimohira, et al. "In Vitro Cytological Responses against Laser Photobiomodulation for Periodontal Regeneration." International Journal of Molecular Sciences 21, no. 23 (2020): 9002. http://dx.doi.org/10.3390/ijms21239002.

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Periodontal disease is a chronic inflammatory disease caused by periodontal bacteria. Recently, periodontal phototherapy, treatment using various types of lasers, has attracted attention. Photobiomodulation, the biological effect of low-power laser irradiation, has been widely studied. Although many types of lasers are applied in periodontal phototherapy, molecular biological effects of laser irradiation on cells in periodontal tissues are unclear. Here, we have summarized the molecular biological effects of diode, Nd:YAG, Er:YAG, Er,Cr:YSGG, and CO2 lasers irradiation on cells in periodontal

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Khodorovskyi, George, Lyubov Panina, and Tetiana Shchurko. "HORMONE-ASSOCIATED METABOLIC DISORDERS OF THE ORAL CAVITY ORGANS IN WOMEN OF REPRODUCTIVE AGE." Problems of Endocrine Pathology 78, no. 4 (2021): 127–34. http://dx.doi.org/10.21856/j-pep.2021.4.17.

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There is emerging evidence of a possible relationship between the oral cavity and reproductive organs. Recent studies suggest these functional relations. The aim of this review was to synthesize the available evidence on this relationship. Clinical observation established that sex hormones enhance gingival inflammation in periodontal healthy women during pregnancy and that periodontal condition is associated with variation of sex hormones in blood. Estrogen regulates DNA synthesis in human gingival epithelial cells and periodontal ligament, estrogen reduces down regulation of cytokines. Estrog

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Aukhil, I., E. Pettersson, and C. Suggs. "Periodontal Wound Healing in the Absence of Periodontal Ligament Cells." Journal of Periodontology 58, no. 2 (1987): 71–77. http://dx.doi.org/10.1902/jop.1987.58.2.71.

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Nagata, Mizuki, Kengo Iwasaki, Keiko Akazawa, et al. "Conditioned Medium from Periodontal Ligament Stem Cells Enhances Periodontal Regeneration." Tissue Engineering Part A 23, no. 9-10 (2017): 367–77. http://dx.doi.org/10.1089/ten.tea.2016.0274.

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Seo, B. M., M. Miura, W. Sonoyama, C. Coppe, R. Stanyon, and S. Shi. "Recovery of Stem Cells from Cryopreserved Periodontal Ligament." Journal of Dental Research 84, no. 10 (2005): 907–12. http://dx.doi.org/10.1177/154405910508401007.

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Human post-natal stem cells possess a great potential to be utilized in stem-cell-mediated clinical therapies and tissue engineering. It is not known whether cryopreserved human tissues contain functional post-natal stem cells. In this study, we utilized human periodontal ligament to test the hypothesis that cryopreserved human periodontal ligament contains retrievable post-natal stem cells. These cryopreserved periodontal ligament stem cells maintained normal periodontal ligament stem cell characteristics, including expression of the mesenchymal stem cell surface molecule STRO-1, single-colon

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Ivanov, Alexey A., Tamara I. Danilova, Alla V. Kuznetsova, Olga P. Popova, and Oleg O. Yanushevich. "Decellularized Matrix Induced Spontaneous Odontogenic and Osteogenic Differentiation in Periodontal Cells." Biomolecules 13, no. 1 (2023): 122. http://dx.doi.org/10.3390/biom13010122.

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The regeneration of periodontal tissues is a decisive factor in the treatment of periodontitis. Currently, to achieve complete periodontal regeneration, many studies have evaluated the effectiveness of decellularized tissue-engineered constructs on periodontal regeneration. We studied the possibilities of osteogenic and odontogenic differentiation of periodontal progenitor and stem cells (SCs) of the periosteum and periodontal ligament, in decellularized tooth matrix (dTM) and periodontal ligament (dPDL), in 2D and 3D culture. The cell culture of periodontal cells without decellularized matric

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Bhatt, Akanksha, Aarati Nayak, K. Satya, and Sachita Naik. "Cells-Aren’t They Stressed Too?" RGUHS Journal of Dental Sciences 14, no. 3 (2022): 25–27. http://dx.doi.org/10.26715/rjds.14_3_5.

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Periodontal disease is an infectious disease caused by several local and systemic risk factors. Stress has been identified as one of the risk factors which influences the progression of periodontal disease. Stress affects a human being as a whole, by inducing multiple changes at the cellular level. This communication focuses on stress at the cellular level, its effect on periodontal disease, and its management. We aim to present the role of naturally available resources and their potential in stress management. These help in maintaining a healthy body and mind, and thereby pave a way for a hea

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Han, Nannan, Yitong Liu, Juan Du, Junji Xu, Lijia Guo, and Yi Liu. "Regulation of the Host Immune Microenvironment in Periodontitis and Periodontal Bone Remodeling." International Journal of Molecular Sciences 24, no. 4 (2023): 3158. http://dx.doi.org/10.3390/ijms24043158.

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The periodontal immune microenvironment is a delicate regulatory system that involves a variety of host immune cells including neutrophils, macrophages, T cells, dendritic cells and mesenchymal stem cells. The dysfunction or overactivation of any kind of local cells, and eventually the imbalance of the entire molecular regulatory network, leads to periodontal inflammation and tissue destruction. In this review, the basic characteristics of various host cells in the periodontal immune microenvironment and the regulatory network mechanism of host cells involved in the pathogenesis of periodontit

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Gigras, Surabhi, Sudhir R. Patil, Veena HR, and Sneha Dani. "Gingival crevicular fluid level of soluble triggering recep-tor expressed on myeloid cells-1(strem-1) in periodontal health and disease: a case-control study." International Journal of Dental Research 5, no. 2 (2017): 83. http://dx.doi.org/10.14419/ijdr.v5i2.7689.

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Background: The Triggering Receptor Expressed On Myeloid Cells-1(TREM-1) is a cell-surface receptor of the immunoglobulin superfamily and found to be involved in the amplification of the inflammatory response to various microbial infections, including periodontal diseases.Objectives: The present study was designed to examine gingivalcrevicular fluid(GCF) levels of soluble TREM-1 (sTREM-1) levels in periodontal health and disease as well as evaluate the effect of scaling and/or root planing on the same.Methods: Based on gingival index, probing pocket depth, clinical attachment level, and radiol

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Cho, Young-Dan, Kyoung-Hwa Kim, Hyun-Mo Ryoo, Yong-Moo Lee, Young Ku, and Yang-Jo Seol. "Recent Advances of Useful Cell Sources in the Periodontal Regeneration." Current Stem Cell Research & Therapy 14, no. 1 (2019): 3–8. http://dx.doi.org/10.2174/1574888x13666180816113456.

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Background: Periodontitis is an inflammatory disease that can result in destruction of the tooth attachment apparatus. Therefore, periodontal tissue regeneration is currently an important focus of research in the field. Approaches using stem cells and reprogrammed cells, such as induced pluripotent stem cells (iPSCs) or trans-differentiated cells, represent the cutting edge in periodontal regeneration, and have led to many trials for their clinical application. Objectives and Results: In this review, we consider all available stem cell sources, methods to obtain the cells, their capability to

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Wang, Penglai, Wen Wang, Tengyu Geng, et al. "EphrinB2 regulates osteogenic differentiation of periodontal ligament stem cells and alveolar bone defect regeneration in beagles." Journal of Tissue Engineering 10 (January 2019): 204173141989436. http://dx.doi.org/10.1177/2041731419894361.

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EphrinB2, a membrane protein regulating bone homeostasis, has been demonstrated to induce osteogenic gene expression in periodontal ligament fibroblasts. The aim of this study was to explore the effects of ephrinB2 on osteogenic differentiation of periodontal ligament stem cells and on alveolar bone regeneration in vivo. We assessed the osteogenic gene expression and osteogenic differentiation potential of ephrinB2-modified human and canine periodontal ligament stem cells, in which ephrinB2 expression was upregulated via lentiviral vector transduction. EphrinB2-modified canine periodontal liga

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Onizuka, Satoru, and Takanori Iwata. "Application of Periodontal Ligament-Derived Multipotent Mesenchymal Stromal Cell Sheets for Periodontal Regeneration." International Journal of Molecular Sciences 20, no. 11 (2019): 2796. http://dx.doi.org/10.3390/ijms20112796.

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Periodontitis is a chronic inflammatory disorder that causes destruction of the periodontal attachment apparatus including alveolar bone, the periodontal ligament, and cementum. Dental implants have been routinely installed after extraction of periodontitis-affected teeth; however, recent studies have indicated that many dental implants are affected by peri-implantitis, which progresses rapidly because of the failure of the immune system. Therefore, there is a renewed focus on periodontal regeneration aroundnatural teeth. To regenerate periodontal tissue, many researchers and clinicians have a

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Khaphi, Fatin, Hanaa Hussein, Oula Hameed, Huda Jebur, and Zahra Saeed. "Role of CD117 and mast cells in periodontal diseases: Histological and immunohistochemical study." Journal of Advanced Biotechnology and Experimental Therapeutics 8, no. 1 (2025): 182. https://doi.org/10.5455/jabet.2025.15.

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Mast cells are mobile secretory cells with a variety of biological tasks such as phagocytosis, processing of antigens, cytokine production, and the release of both newly formed and preexisting physiological mediators. This study aimed to investigate and establish the relationship between mast cells and various stages of periodontal diseases. A total of 36 soft tissue samples, 12 each of normal healthy periodontal, dental plaque periodontitis, and chronic periodontitis were selected. Samples were collected from patients with periodontal surgery in chronic periodontitis and plaque periodontitis.

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Okada, H., Y. Shimabukuro, Y. Kassai, et al. "The Function of Gingival Lymphocytes on the Establishment of Human Periodontitis." Advances in Dental Research 2, no. 2 (1988): 364–67. http://dx.doi.org/10.1177/08959374880020022801.

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Human periodontitis has been confirmed to be an IgG plasma cell-rich lesion. However, we also detected many T cells, both CD4-positive and CD8-positive cells, in periodontal lesions. Some of these T cells expressed HLA-DR (la-like) antigen on their surfaces, and the proportion of HLA-DR+ cells was approximately equal in both CD4+ and CD8+ cell populations (Okada et al., 1983, 1984). Consequently, both helper and suppressor T cells were believed to participate in the establishment of periodontal lesions. On the other hand, B cells were thought to be activated polyclonally in periodontal lesions

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Popovici, Ramona, Raluca Ceausu, Anca Cimpean, Talpos Serban, Marius Raica, and Pusa Gaje. "Mast cells as key players in periodontal disease." Archives of Biological Sciences 66, no. 2 (2014): 801–9. http://dx.doi.org/10.2298/abs1402801p.

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Mast cell (MC) active mediators promote inflammation through changes induced in the connective tissue components of human gingiva. The aim of this study was to evaluate the distribution, mast cell density and their relationship with the degree of inflammatory infiltrate in gingiva from patients with periodontal disease. Thirty-nine cases with periodontal disease and 12 cases without significant changes to the gingival mucosa were investigated. MCs were identified on paraffin-embedded specimens by immunohistochemistry using anti-mast cell tryptase. The inflammatory infiltrate was scored from 0

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Hatakeyama, J., D. Philp, Y. Hatakeyama, et al. "Amelogenin-mediated Regulation of Osteoclastogenesis, and Periodontal Cell Proliferation and Migration." Journal of Dental Research 85, no. 2 (2006): 144–49. http://dx.doi.org/10.1177/154405910608500206.

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We previously reported that amelogenin isoforms M180 and leucine-rich amelogenin peptide (LRAP) are expressed in the periodontal region, and that their absence is associated with increased cementum defects in amelogenin-knockout (KO) mice. The aim of the present study was to characterize the functions of these isoforms in osteoclastogenesis and in the proliferation and migration of cementoblast/periodontal ligament cells. The co-cultures of wild-type (WT) osteoclast progenitor and KO cementoblast/periodontal ligament cells displayed more tartrate-resistant acid phosphatase (TRAP)-positive cell

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Benatti, Bruno Braga, Karina Gonzales Silvério, Márcio Zaffalon Casati, Enílson Antônio Sallum, and Francisco Humberto Nociti. "Physiological features of periodontal regeneration and approaches for periodontal tissue engineering utilizing periodontal ligament cells." Journal of Bioscience and Bioengineering 103, no. 1 (2007): 1–6. http://dx.doi.org/10.1263/jbb.103.1.

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Komala, Devi, Muhammad Nurul Amin, and Yani Corvianindya Rahayu. "Uji Sitotoksisitas Hidroksiapatit Cangkang Telur Ayam Ras (Gallus gallus) terhadap Sel Fibroblas Ligamen Periodontal Manusia." STOMATOGNATIC - Jurnal Kedokteran Gigi 19, no. 1 (2022): 49. http://dx.doi.org/10.19184/stoma.v19i1.30702.

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Periodontitis is an inflammation disease of the periodontal tissues surrounding the teeth, include periodontal ligament fibroblast cell. The recently researches developed tissue engineering concept to accelerate regeneration and proliferation periodontal ligament cells. One of the major components of tissue engineering is scaffold. The hydroxyapatite is biomaterial that can be used as scaffold. The egg shell has the potential biowaste to be a source of hydroxyapatite biomaterial. Before being applied as a scaffold in the medical field, cytotoxicity testing needs to be done. This study aimed to

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Rath-Deschner, Birgit, Svenja Memmert, Anna Damanaki, et al. "CXCL1, CCL2, and CCL5 modulation by microbial and biomechanical signals in periodontal cells and tissues—in vitro and in vivo studies." Clinical Oral Investigations 24, no. 10 (2020): 3661–70. http://dx.doi.org/10.1007/s00784-020-03244-1.

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Abstract Objectives This study was established to investigate whether the chemokines CXCL1, CCL2, and CCL5 are produced in periodontal cells and tissues and, if so, whether their levels are regulated by microbial and/or mechanical signals. Materials and methods The chemokine expression and protein levels in gingival biopsies from patients with and without periodontitis were analyzed by RT-PCR and immunohistochemistry. The chemokines were also analyzed in gingival biopsies from rats subjected to experimental periodontitis and/or orthodontic tooth movement. Additionally, chemokine levels were de

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Lauer, Günter, and Byung Ho Choi. "The ultrastructure of the periodontal ligament cells-titanium interface with vitro." Malaysian Journal of Oral and Maxillofacial Surgery 1, no. 1 (2000): 11–16. https://doi.org/10.4103/mjoms_200011_11.

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Several studies have shown that a peridontal ligament can form on titanium dental implants which were placed in contact with the periodontal ligament of the retained roots. However, the following question is still critical: how do the periodontal ligament cells adhere to the implant surface? Little is known about the ultrastructure of the periodontal ligament cells-titanium interface. The objective of this study, therefore, was to gain insight into the morphology of the interface. Human periodontal ligament cells were cultured on thin titanium substrates obtained by electron beam evaporation o

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Rath-Deschner, Birgit, Andressa Vilas Boas Nogueira, Svenja Memmert, et al. "Regulation of Anti-Apoptotic SOD2 and BIRC3 in Periodontal Cells and Tissues." International Journal of Molecular Sciences 22, no. 2 (2021): 591. http://dx.doi.org/10.3390/ijms22020591.

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The aim of the study was to clarify whether orthodontic forces and periodontitis interact with respect to the anti-apoptotic molecules superoxide dismutase 2 (SOD2) and baculoviral IAP repeat-containing protein 3 (BIRC3). SOD2, BIRC3, and the apoptotic markers caspases 3 (CASP3) and 9 (CASP9) were analyzed in gingiva from periodontally healthy and periodontitis subjects by real-time PCR and immunohistochemistry. SOD2 and BIRC3 were also studied in gingiva from rats with experimental periodontitis and/or orthodontic tooth movement. Additionally, SOD2 and BIRC3 levels were examined in human peri

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Rath-Deschner, Birgit, Andressa Vilas Boas Nogueira, Svenja Memmert, et al. "Regulation of Anti-Apoptotic SOD2 and BIRC3 in Periodontal Cells and Tissues." International Journal of Molecular Sciences 22, no. 2 (2021): 591. http://dx.doi.org/10.3390/ijms22020591.

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The aim of the study was to clarify whether orthodontic forces and periodontitis interact with respect to the anti-apoptotic molecules superoxide dismutase 2 (SOD2) and baculoviral IAP repeat-containing protein 3 (BIRC3). SOD2, BIRC3, and the apoptotic markers caspases 3 (CASP3) and 9 (CASP9) were analyzed in gingiva from periodontally healthy and periodontitis subjects by real-time PCR and immunohistochemistry. SOD2 and BIRC3 were also studied in gingiva from rats with experimental periodontitis and/or orthodontic tooth movement. Additionally, SOD2 and BIRC3 levels were examined in human peri

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Chandra, R. Viswa, Ganesh Chandra Jagetia, and K. Mahalinga Bhat. "The Attachment of V79 and Human Periodontal Ligament Fibroblasts on Periodontally Involved Root Surfaces Following Treatment with EDTA, Citric Acid, or Tetracycline HCL: An SEM in vitro Study." Journal of Contemporary Dental Practice 7, no. 1 (2006): 35–43. http://dx.doi.org/10.5005/jcdp-7-1-35.

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Abstract Objective The present in vitro study has been designed to establish and compare the effects of citric acid, EDTA, and tetracycline HCl on human periodontally diseased roots on the structure, attachment, and orientation of V79 (primary Chinese hamster lung fibroblasts) cells and human periodontal ligament fibroblasts (HPDL). Materials and Methods Commercially availableV79 cells and HPDL derived from healthy human third molars were used in this study. These fibroblasts were left in solution for seven days in order to attain confluence. Forty single-rooted teeth were obtained from patien

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