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Journal articles on the topic 'Periodontal Disease,Genetic evaluation'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

K.Z., Adilov, Rizaev J.A., and Adilova Sh.T. "DIAGNOSTIC AND PROGNOSTIC SIGNIFICANCE OF GINGIVAL FLUID CYTOKINES IN THE DEVELOPMENT OF INFLAMMATORY PERIODONTAL DISEASES." American Journal of Medical Sciences and Pharmaceutical Research 6, no. 7 (2024): 12–18. http://dx.doi.org/10.37547/tajmspr/volume06issue07-03.

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Inflammatory periodontal diseases are one of the most common dental diseases in the world, along with dental caries. In the modern concept of the development of inflammatory periodontal diseases, one of the important roles is assigned to the body's immune response to the action of periodontal pathogenic microorganisms. In modern scientific literature, the concept of cytokine development of inflammatory periodontal diseases has been formed and substantiated. Evaluation of the cytokine profile of oral and gingival fluids allows us to determine the activity and severity of the disease. Well-found

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Gomes Viana, Mariana Vitória, Júlia Santos Cerqueira, and Regina Lucia Seixas Pinto. "APLICAÇÃO DIAGNÓSTICA DE IMAGENS TRIDIMENSIONAIS (3D) NA DOENÇA PERIODONTAL DIAGNOSTIC APPLICATION OF THREE-DIMENSIONAL IMAGES (3D) IN PERIODONTAL DISEASE." Revista da Faculdade de Odontologia da Universidade Federal da Bahia 50, no. 1 (2020): 57–51. http://dx.doi.org/10.9771/revfo.v50i1.37117.

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A doença periodontal é uma doença altamente prevalente na populaçãomundial e se caracteriza pela destruição progressiva do ligamento periodontale reabsorção da crista óssea alveolar interdental e interradicular. Temcomo fatores etiológicos as bactérias do biofilme que associadas aos fatoresgenéticos e ambientais geram uma resposta inflamatória liberam enzimasproteolíticas e danificam o tecido de suporte dental. A avaliação da perdada inserção periodontal por exame clínico é limitada pelos instrumentosde sondagem e condições anatômicas, portanto, imagens radiográficas sãoinevitáveis para determ

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Tarannum, Fouzia, and Mohamed Faizuddin. "Effect of Alox-15 Polymorphism on GCF Levels of Lipoxin-A4 in Chronic Periodontitis: A Preliminary Study." Brazilian Dental Journal 28, no. 2 (2017): 140–47. http://dx.doi.org/10.1590/0103-6440201701094.

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Lipoxins play an important role in periodontal resolution, hence, investigation of genetic polymorphism of lipoxin gene may provide important information on the role of lipoxins in periodontal disease pathogenesis. The aim of this study was to investigate a polymorphism of C-to-T substitution at position c.-292 in ALOX15 (reticulocyte-type 15 lipoxygenase 1) gene in patients with chronic periodontitis and to associate the polymorphism with gingival crevicular fluid (GCF) lipoxin A4 (LXA4) levels. Forty-five chronic periodontitis and 45 periodontally healthy patients were included in this case-

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Дзюба, Елена, Elena Dzyuba, Марина Нагаева, Marina Nagaeva, Екатерина Жданова, and Ekaterina Zhdanova. "THE ROLE OF IMMUNOLOGICAL PROCESSES IN THE DEVELOPMENT OF INFLAMMATORY DISEASES OF PERIODONTAL DISEASE AND THE POSSIBILITIES OF THEIR CORRECTION." Actual problems in dentistry 15, no. 2 (2019): 25–31. http://dx.doi.org/10.18481/2077-7566-2019-15-2-25-31.

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Subject: Inflammatory periodontal diseases are one of the most common dental diseases in the world. To ensure successful treatment and a stable period of remission, it is necessary to take into account the etiopathogenesis of the disease. One of the main roles in the development of inflammatory periodontal diseases is played by the immune response of the body to the action of periodontal-pathogenic micro-organisms. Objective ― to study the current literature indicates about the role of immunological processes in the development of inflammatory periodontal diseases, as well as the possibi

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Dolińska, Ewa, Patryk Wiśniewski, and Małgorzata Pietruska. "Periodontal Molecular Diagnostics: State of Knowledge and Future Prospects for Clinical Application." International Journal of Molecular Sciences 25, no. 23 (2024): 12624. http://dx.doi.org/10.3390/ijms252312624.

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Periodontitis leads to immunologically mediated loss of periodontium and, if untreated, can result in tooth loss. Periodontal diseases are the most prevalent in the world and have a very strong impact on patients’ well-being and general health. Their treatment generates enormous costs. Given the above, precise, prompt, and predictive diagnosis of periodontal disease is of paramount importance for clinicians. The aim of the study was to summarize the state-of-the-art knowledge of molecular periodontal diagnostics and the utility of its clinical application. There is a great need to have diagnos

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Corrêa, Jôice Dias, Amanda Leal Rocha, Lidiane Cristina Machado Costa, et al. "Severe Periodontal Disease Associated with Long-Term Treatment with Intravenous Immunoglobulin." Case Reports in Dentistry 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/860804.

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Intravenous immunoglobulin (IVIG) is used in the treatment of neuropathy. This case report presents, for the first time, a patient with severe periodontal destruction after chronic therapy with IVIG. The patient reported having extracted his maxillary anterior teeth himself due to high mobility. Clinical examination and radiographic images show a generalized and severe periodontitis. No significant alterations in genetic or microbiological features were observed. The present case suggests that periodontal disease aggravation could be considered a new adverse effect of IVIG therapy. Postulated

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Bhoir, Vrushali. "The Complex Interplay between C-reactive Protein and Periodontal Health: A Narrative Review." Asian Journal of Pharmaceutical Research and Health Care 16, no. 1 (2024): 3–8. http://dx.doi.org/10.4103/ajprhc.ajprhc_117_23.

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ABSTRACT Aim: The aim of this review is to comprehensively explore and elucidate the intricate relationship between C-reactive protein (CRP) levels and periodontal health. It involves an examination of the existing literature to understand the role of CRP as a biomarker and potential mediator in the pathogenesis, progression, and management of periodontal disease. Material and Methods: A literature search was conducted between January 2010 and December 2023, in PubMed/MEDLINE, Google Scholar, and Scopus databases, using keywords such as “acute phase reactants,” “C-reactive protein,” “cardiovas

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Rakhewar, P. S., Anand Gaikwad, Sanket Panpatil, Lisa Chacko, Saurabh Patil, and Manjunath S. H. "Role of Proteomic Biomarkers in Periodontal Diseases - A Review." Scholars Journal of Dental Sciences 10, no. 09 (2023): 196–201. http://dx.doi.org/10.36347/sjds.2023.v10i09.001.

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The biochemical analysis of saliva is particularly important in dentistry. Estimation of the risk of disease onset and severity, monitoring of disease progression and evaluation of therapeutic efficacy for premalignant and malignant oropharyngeal lesions as well as infectious diseases of the oral cavity can be performed by analyzing an array of constituents within saliva. Although there is a large body of literature on gingival crevicular fluid biomarkers, this review limits itself to saliva analysis. Salivary constituents that have been studied as potential diagnostic biomarkers for periodont

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Sadasivan, Arun, Roshni Ramesh, and Deepu George Mathew. "Ligneous Periodontitis in a Patient with Type 1 Plasminogen Deficiency: A Case Report and Review of the Literature." Case Reports in Dentistry 2020 (March 26, 2020): 1–8. http://dx.doi.org/10.1155/2020/5680535.

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Background. Ligneous periodontitis or destructive membranous periodontal disease is a rare condition involving gingival tissues, which is due to plasminogen deficiency and fibrin deposition. Plasminogen deficiency is an ultrarare autosomal recessive disease. The disease is characterized by gingival enlargement and periodontal tissue destruction that leads to rapid tooth loss despite treatment attempts. A defect in fibrinolysis and abnormal wound healing are the main pathogenesis of this condition. It is caused by mutations in PLG, the gene coding for plasminogen, which results in decreased lev

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Ippolitov, Yu A., T. V. Chubarov, O. G. Sharshova, I. N. Buzulukina, D. M. Folomeeva, and Ch Ch Chan. "Clinical laboratory assessment and predictability of the periodontal inflammation development in children with undifferentiated connective tissue disease." Pediatric dentistry and dental profilaxis 21, no. 3 (2021): 199–204. http://dx.doi.org/10.33925/1683-3031-2021-21-3-199-204.

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Relevance. The development of multiple organ lesions in undifferentiated connective tissue disease leads to secondary immunodeficiency, which triggers oral homeostasis disruption and activates periodontal pathogens, which produce anti-inflammatory cytokines, which trigger the mechanisms of periodontal destruction. Purpose – to establish the relationship between undifferentiated connective tissue disease in children and their predisposition to periodontal inflammation and destruction.Materials and methods. The study examined the patients, aged 15 to 17 years old, of the endocrinological departm

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Dalal, Rakshit K., Manpreet Kaur, Komal Khatri, Foram Patel, Heena Shaikh, and Arifa Bakerywala. "Evaluation of the Circulatory Levels of Heat Shock Protein 60 Levels in Periodontitis and Cardiovascular Disease Patients." Journal of Pharmacy and Bioallied Sciences 16, Suppl 1 (2024): S498—S500. http://dx.doi.org/10.4103/jpbs.jpbs_829_23.

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ABSTRACT Introduction: HSP is arguably the most thoroughly studied self-antigens connected to Cardio Vascular Diseases (CVD) and periodontal disease. Hence, the major goal of this analysis was to determine the amount of HSP60 in patients’ Chronic Periodontitis (CP) patients’ serum. Materials and Methods: The current investigation involved 100 patients in all. Based on the patients’ periodontal and cardiovascular health, the patients were divided. The patients were made aware that this research had no direct bearing on disease treatment or cure. Results: In contrast to periodontal disease, whic

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Buzinin, Samira Mukhtar, Aied Mohammed Alabsi, Alexander Tong Boon Tan, Vui King Vincent-Chong, and Dasan Swaminathan. "Effects of Nonsurgical Periodontal Therapy on Clinical Response, Microbiological Profile, and Glycemic Control in Malaysian Subjects with Type 1 Diabetes." Scientific World Journal 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/232535.

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The association between diabetes mellitus and chronic periodontal disease has long been established. Most of the researches linking these two very common chronic diseases were based on type 2 diabetes mellitus and chronic periodontal disease. However, this study was conducted to investigate the association between type 1 diabetes and chronic periodontal disease in Malaysian subjects. Forty-one Malaysian subjects, of which 20 subjects were type 1 diabetics and with chronic periodontal disease (test group) and 21 subjects with only chronic periodontal disease (control group), were included in th

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Kdkhodazadeh, Mahdi, Mehrdad Hajilooi, Behzad Houshmand, Sara Khazaei, Leila Gholami, and Sara Alijani. "Evaluation of PECAM-1 Gene Polymorphism in Patients with Periodontal Disease and Healthy Individuals." ISRN Dentistry 2012 (March 5, 2012): 1–5. http://dx.doi.org/10.5402/2012/751920.

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Objective. Our aim in this paper was to investigate the possible genetic association between three Ser563Asn, Leu125Val and Arg670Gly polymorphisms of the PECAM-1 gene and periodontitis. Methods. Genomic DNA was isolated from whole blood of 105 periodontal patient (52 with chronic periodontitis and 53 with aggressive periodontitis) and 101 healthy individuals. Samples were genotyped and analyzed for the three single-nucleotide polymorphisms (SNPs) of PECAM-1 using polymerase chain reaction with sequence-specific primers (PCR-SSPs). Results. A statistically significant difference was found betw

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Pant, Bhawana Neupane, Rajesh Kumar Goit, Biswas Satyal, and Abhishek Poudel. "Prevalence of Periodontitis among the People with Diabetes Mellitus." Journal of Nepalgunj Medical College 18, no. 2 (2021): 72–74. http://dx.doi.org/10.3126/jngmc.v18i2.38915.

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Introduction: Diabetes mellitus is a metabolic disorder characterized by a chronic high level of blood sugar with disturbances in carbohydrate, fat, and protein metabolism resulting from defects in insulin secretion, action or both. Periodontitis is a chronic infectious disease which leads to the destruction of the periodontal ligament fibers and alveolar bone until tooth loss. Among the several factors that may manifest periodontitis like aging, genetic factors, poor oral hygiene, obesity and virulence of the attacking micro-organisms, type 2 diabetes mellitus has received the greatest attent

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Tamarova, E. R., K. Yu Shvets, A. R. Mavzyutov, Al H. Baimiev, and A. I. Bulgakova. "CREATION OF A MOLECULAR GENETIC TEST SYSTEM FOR EARLY DIAGNOSTICS AND EVALUATION OF EFFECTIVENESS OF TREATMENT OF INFLAMMATORY PERIODONTAL DISEASES." Russian Clinical Laboratory Diagnostics 65, no. 1 (2020): 55–60. http://dx.doi.org/10.18821/0869-2084-2020-65-1-55-60.

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Inflammatory periodontal diseases represent a serious dental and general medical problem due to the high prevalence among the adult population, the presence of clinical forms leading to the destruction of the dentition and tooth loss, insufficient treatment effectiveness and the frequency of relapse, including in connection with the formation of biofilms. A molecular genetic test system has been developed to evaluate the content of periodontopathogenic microorganisms Porphyromonas gingivalis, Treponema denticola, Streptococcus oralis, Streptococcus sanguis and Streptococcus sobrinus in the con

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Mirnic, Jelena, Milanko Djuric, Tanja Veljovic, et al. "Evaluation of Lipid Peroxidation in the Saliva of Diabetes Mellitus Type 2 Patients with Periodontal Disease." Biomedicines 10, no. 12 (2022): 3147. http://dx.doi.org/10.3390/biomedicines10123147.

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As oxidative stress has been implicated in the pathogenesis of diabetes mellitus and periodontitis, it may serve as a link between these conditions. Therefore, as a part of the present study, salivary lipid peroxidation (LP) in periodontitis patients with and without diabetes mellitus type 2 (DM2) was evaluated, along with the periodontal therapy effectiveness. The study sample comprised of 71 DM2 patients with periodontitis and 31 systemically healthy controls suffering from periodontitis of comparable severity. In all participants, periodontal indices—plaque index (PI), gingival index (GI),

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Fatemi, Kazem, Seyed Abdolrahim Rezaee, Amir Moeintaghavi та ін. "Comparative evaluation of IL-17 and TGF-β expression in tissues of patients with chronic periodontitis and healthy individuals using real-time PCR". Journal of Advanced Periodontology & Implant Dentistry 10, № 1 (2018): 8–12. http://dx.doi.org/10.15171/japid.2018.002.

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Background. The present study aimed to determine the association between periodontal disease and the Th17/Treg balance by examining the genetic expression of IL-17 and TGF-β, which influence incidence and suppression of inflammation. Methods. In this case-control study, samples were collected in a randomized and task-oriented order. Thirty-seven patients referred to professional periodontology clinics in Mashhad and the Periodontology Department of the Mashhad Dentistry Faculty for periodontal (case) or crown-length (control) surgery was enrolled. IL-17 and TGF-β gene expression indices were m

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Ma, Rui, Fardad Moein Vaziri, Gregory Sabino, et al. "Glycogen Storage Disease Ib and Severe Periodontal Destruction: A Case Report." Dentistry Journal 6, no. 4 (2018): 53. http://dx.doi.org/10.3390/dj6040053.

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Background: Glycogen storage diseases (GSDs) are genetic disorders that result from defects in the processing of glycogen synthesis or breakdown within muscles, liver, and other cell types. It also manifests with impaired neutrophil chemotaxis and neutropenic episodes which results in severe destruction of the supporting dental tissues, namely the periodontium. Although GSD Type Ib cannot be cured, associated symptoms and debilitating oral manifestations of the disease can be managed through collaborative medical and dental care where early detection and intervention is of key importance. This

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Devanoorkar, Archana, C. D. Dwarakanath, Gayatri Gundanavar, Rahul Kathariya, and Sudhir R. Patil. "Evaluation of Serum Resistin Levels in Periodontal Health and Disease and Effects of Non Surgical Periodontal Therapy on Its Levels." Disease Markers 32, no. 5 (2012): 289–94. http://dx.doi.org/10.1155/2012/153418.

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Background: Resistin and adiponectin are the adipokines secreted by adipocytes and various inflammatory cells. These adipokines are known to play an important role in insulin resistance. The aim of this study was to determine the serum resistin levels in periodontal health and disease and also, to determine the effect of nonsurgical periodontal therapy on its levels.Methods: A total of 40 patients (20 Males and 20 Females; age range 20–50 years) participated in the study. Subjects were categorized as healthy (group 1; Controls) and chronic periodontitis (group 2; Study) groups based on their p

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Nóbrega, Lara Mayanne Moreira de Oliveira, Fernanda Sthéfanie Medeiros de Araújo, Husdson Kaio Da Costa Nóbrega, et al. "Evaluation of the Antibacterial Activity of Gaultheria procumbens Essential Oil Against Klebsiella pneumoniae Strains." European Journal of Medical and Health Sciences 5, no. 6 (2023): 33–37. http://dx.doi.org/10.24018/ejmed.2023.5.6.1930.

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The oral biofilm contains a wide variety of microorganisms, mostly bacteria, which are responsible for the development of various infections, such as periodontal disease. Periodontal disease is of infectious and inflammatory origin, caused by the present in the biofilm. It acts by destroying the protective and supporting tissues of the dental elements, involving local, systemic, environmental, and genetic factors. Studies show that periodontal disease is directly related to various systemic morbidities, among which we can highlight respiratory problems, where nosocomial pneumonia has stood out

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Pulat, Selman, and Kurtuluş Parlak. "Clinical, Radiological and Hematological Evaluation in Cats with Tooth Resorption." Dicle Üniversitesi Veteriner Fakültesi Dergisi 18, no. 1 (2025): 6–12. https://doi.org/10.47027/duvetfd.1599449.

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This study aimed to investigate tooth resorption (TR), a common dental disease in cats. Conducted on 35 cats admitted to Selçuk University Faculty of Veterinary Medicine Animal Hospital for oral health issues or castration, the study evaluated the prevalence of TR, the distribution of affected teeth, and the relationship between resorption types and stages. Clinical and radiographic examinations were performed, and blood parameters were analyzed. The findings indicated that TR prevalence increases with age and is most commonly observed in mandibular third premolars and first molars. Blood anal

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Grippaudo, Cristina, Concetta Cafiero, Nicola Maria Grande, et al. "Genetic Testing as a Source of Information Driving Diagnosis and Therapeutic Plan in a Multidisciplinary Case." Bioengineering 11, no. 10 (2024): 1023. http://dx.doi.org/10.3390/bioengineering11101023.

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In many cases, the etiopathogenesis of oral cavity diseases depends on the presence of variants in some genes. Being able to identify these variants defines the possibilities and limits of therapies. This multidisciplinary case describes several pathologies of the oral cavity in a young patient affected by type 1 diabetes. The patient presented with an impacted palatal canine. Further investigation revealed cervical root resorption of the upper right central incisor. Genetic testing was performed for interleukin, VDR receptor genes, and the evaluation of periodontopathogenic bacteria. The muta

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Nurhayati Abdullah, Haswati, Suharni Mohamad, Wan Rohani WanTaib, and Norzawani Jaffar. "Quorum sensing related activity of Aggregatibacter actinomycetemcomitans in periodontal disease: A review." Biomedicine 41, no. 2 (2021): 174–80. http://dx.doi.org/10.51248/.v41i2.778.

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Aggregatibacter actinomycetemcomitans is a significant pathogen in periodontal disease, contributing to aggressive and chronic inflammatory conditions of the periodontal area. This pathogen is shown to contribute to the tenacious biofilm formation in the oral cavity and results in persistent induction of pro-inflammatory response leads to progressive periodontitis. Besides the immune-modulatory capabilities, quorum sensing (QS) activity is believed to influence the virulence activities, leading to a progressive inflammatory response by the host. QS modulates the expression of genes involved in

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Genco, R. J., T. E. Van Dyke, M. J. Levine, R. D. Nelson, and M. E. Wilson. "1985 Kreshover lecture. Molecular Factors Influencing Neutrophil Defects in Periodontal Disease." Journal of Dental Research 65, no. 12 (1986): 1379–91. http://dx.doi.org/10.1177/00220345860650120201.

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Major advances in our understanding of the role of the neutrophil in host defense against periodontal organisms have been made through studies of localized juvenile periodontitis (LJP). Several.lines of evidence suggest that LJP is an infectious process closely associated with Actinobacillus (Haemophilus) actinomycetemcomitans as a causative agent, although other organisms may also participate. The immunologic profile of LJP patients suggests that a cell-associated neutrophil locomotory dysfunction is a key underlying immunodeficiency resulting in increased susceptibility to periodontal infect

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Bhagat, Shweta, Priyanka Jaiswal, and Deepika Masurkar. "Comparative evaluation of the effectiveness of bioresorbable collagen membrane in combination with deproteinized bovine bone matrix xenograft (DBBM), and advanced platelet rich fibrin membrane in combination with deproteinized bovine bone matrix xenograft for periodontal regeneration." F1000Research 12 (August 31, 2023): 1069. http://dx.doi.org/10.12688/f1000research.135078.1.

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Introduction: Periodontitis is a chronic, multifactorial, inflammatory disease that leads to gradual loss of bone and periodontal attachment. Thus, periodontal surgery is required according to severity of diseases. The goal of periodontal reconstructive surgery is to regenerate soft and hard tissues destroyed during periodontal disease. Aim: To compare the effectiveness of bioresorbable collagen membrane in combination with Deproteinized Bovine Bone Matrix xenograft (group A); and Advanced Plasma rich fibrin(A-PRF) membrane in combination with Deproteinized Bovine Bone Matrix xenograft (group

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N. Kedlaya, Madhurya, Lakshmi Puzhankara, Mansi Mahendra, et al. "Knowledge, Attitude and Practice regarding the effect of yoga on periodontal health among Indian adults: A questionnaire study." F1000Research 12 (October 25, 2023): 1404. http://dx.doi.org/10.12688/f1000research.140245.1.

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Background: Periodontal disease is a chronic inflammatory disease affecting the structures supporting the teeth and has multifactorial etiology. Conventionally, management of periodontal disease involves non-surgical and surgical procedures, while LASER, phytotherapy are some of the adjuncts to the conventional methods. In India, complementary medicine and alternative medicines like yoga are gaining popularity for improving systemic health. However, the effect of yoga on oral or periodontal health has not been explored extensively. Hence, this pilot study was designed to develop a validated, r

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Scapoli, Luca, Francesco Carinci, Damiano Mucchi, et al. "Evaluation of IL6, IL10 and VDR alleles distribution in an Italian large sample of subjects affected by chronic periodontal disease." International Journal of Immunopathology and Pharmacology 33 (January 2019): 205873841984084. http://dx.doi.org/10.1177/2058738419840844.

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In recent decades, the role played by the immune response to bacteria in the pathogenesis of chronic periodontal disease (PD) has long been studied. Although from the clinical point of view, adequate oral hygiene is essential to ensure a satisfactory response of the host to infections, modulation of the reaction of immune system could be influenced by genetic factors. The aim of the present study was to investigate the distribution of alleles of polymorphisms relevant for chronic periodontitis in a sample of adult subjects affected by chronic PD. The present study was conducted with sample col

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Skulskaya, S. V., T. G. Verbickaya та S. A. Shnajder. "PROBABILITY OF DENTAL PATHOLOGY DEVELOPMENT IN CHILDREN RESIDING IN ZONES OF VARIOUS ANTHROPOGENIC LOADS BASED ON MOLECULAR GENETIC EVALUATION OF POLYMORPHISMS OF І AND ІІ PHASE OF DETOXICATION". EurasianUnionScientists 3, № 3(72) (2020): 37–41. http://dx.doi.org/10.31618/esu.2413-9335.2020.3.72.637.

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Relevance. Adverse environmental conditions and man-made disasters are not considered as air, soil and groundwater oversaturated environmental pollutants and toxicants. They cause disturbances in biochemical reactions and metabolic processes in childhood and at a young age. The aim of this study was to determine the effect of polymorphism of the detoxification gene of the first phase Cyp1A1 (A1506G) and the second phase genes GSTM1, GSTT1, on hard tissue indices of permanent teeth, periodontal indices and oral hygiene indices in children living in areas of different anthropogenic stress. Mater

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Nicchio, Ingra G., Thamiris Cirelli, Rafael Nepomuceno, et al. "Polymorphisms in Genes of Lipid Metabolism Are Associated with Type 2 Diabetes Mellitus and Periodontitis, as Comorbidities, and with the Subjects’ Periodontal, Glycemic, and Lipid Profiles." Journal of Diabetes Research 2021 (November 11, 2021): 1–21. http://dx.doi.org/10.1155/2021/1049307.

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Background. Type 2 diabetes mellitus (T2DM) and periodontitis (P) commonly occur as comorbidities, but the commonalities in the genetic makeup of affected individuals is largely unknown. Since dyslipidemia is a frequent condition in these individuals, we investigate the association of genomic variations in genes involved in lipid metabolism with periodontal, glycemic, lipid profiles, and the association with periodontitis and T2DM (as comorbidities). Methods. Based on clinical periodontal examination and biochemical evaluation, 893 subjects were divided into T2DM+P (T2DM subjects also affected

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Heneberk, Ondrej, Andrea Vernerova, Lenka Kujovska Krcmova, Eliska Wurfelova, and Vladimira Radochova. "Neopterin Levels in Periodontitis and after Nonsurgical Periodontal Therapy: Evaluation of Gingival Crevicular Fluid, Oral Fluid, Serum and Urinary Samples—A Case-Control Study." Biomedicines 10, no. 12 (2022): 3200. http://dx.doi.org/10.3390/biomedicines10123200.

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Periodontitis is a chronic inflammatory disease that leads to the destruction of the tooth-supporting tissues with complex immune response. Neopterin (Np), secreted via activated macrophages, is considered a biomarker of cellular immunity. The aim of this study was to evaluate the impact of periodontitis and nonsurgical periodontal therapy. Np gingival crevicular fluid (GCF), oral fluid, serum and urine levels were compared in subjects with periodontitis before periodontal treatment, three months after and in a healthy control. Np GCF concentrations in the study group after treatment were sign

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Dos-Santos, R., F. Otero, M. Varela García, E. Perez-Pampín, and A. Mera Varela. "POS0624 RHEUMATOID ARTHRITIS AND ORAL MICROBIOME RELATED TO PERIODONTAL DISEASE." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 580.1–580. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4023.

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BackgroundRheumatoid Arthritis (RA) is a prevalent systemic autoimmune disease with an unknown etiology. Its onset has been related with chronic immune activation.1 Oral microbiome (OM) could be one trigger for this beginning, due to its implication in periodontal disease (PD) and chronic gum inflammation.2ObjectivesTo correlate OM species potentially harmful and RA disease activity.MethodsDuring a 6-month period (June to December 2021), RA patients (from the daily practice in a Rheumatology Department) and healthy controls were recruited. Healthy controls proceed from outpatient Orthopaedic S

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Rosa, Nuno, Maria José Correia, Joel P. Arrais, Nuno Costa, José Luís Oliveira, and Marlene Barros. "The Landscape of Protein Biomarkers Proposed for Periodontal Disease: Markers with Functional Meaning." BioMed Research International 2014 (2014): 1–15. http://dx.doi.org/10.1155/2014/569632.

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Periodontal disease (PD) is characterized by a deregulated inflammatory response which fails to resolve, activating bone resorption. The identification of the proteomes associated with PD has fuelled biomarker proposals; nevertheless, many questions remain. Biomarker selection should favour molecules representing an event which occurs throughout the disease progress. The analysis of proteome results and the information available for each protein, including its functional role, was accomplished using the OralOme database. The integrated analysis of this information ascertains if the suggested p

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Hong, Seok Jin, Bin Kwon, Byoung Eun Yang, Hyo Geun Choi, and Soo Hwan Byun. "Evaluation of the Relationship between Drink Intake and Periodontitis Using KoGES Data." BioMed Research International 2021 (March 16, 2021): 1–8. http://dx.doi.org/10.1155/2021/5545620.

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It was hypothesized that periodontal diseases could be influenced by nutrition and food types. However, the role of nutritional factors in the risk of periodontal disease has not been clearly elucidated. This study was aimed at investigating the relationship between coffee, green tea, or soft drink intake and periodontitis. This prospective cohort study used epidemiological data from 2004 to 2016 from the Korean Genome and Epidemiology Study. Among 173,209 participants, 9,933 with periodontitis and 124,922 controls were selected. The frequency histories of coffee/green tea/soft drink intake am

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Elfasakhany, Fathy M., Omaima N. Al-Qahtani, Asmaa M. Badri, and Hala A. Abuelela. "Analysis of Vitamin D Receptor Gene Polymorphism in Chronic Periodontitis among Saudi Population." European Dental Research and Biomaterials Journal 2, no. 01 (2021): 12–16. http://dx.doi.org/10.1055/s-0041-1727090.

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Abstract Objective Genetic and environmental factors have important roles in the development of periodontitis. We aimed to assess the relation of vitamin D receptor (VDR) ApaI and TaqI polymorphisms and the susceptibility of periodontitis in Saudi population in Makkah region. Materials and Methods In total, 86 unrelated patients with moderate-to-severe periodontitis and 86 controls were enrolled in this study. Evaluation of the periodontal state was performed by using plaque index, bleeding on probing, probing depth, and attachment loss. Extraction of genomic DNA from peripheral blood and geno

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Yadav, Bipin K., Rajesh K. Thakur, Sanjay K. Kannaujia, Rahul Mishra, Geeta Maurya, and Ashutosh Dixit. "Evaluation of the Periodontal Inflammatory Effect on Erythrocyte Sedimentation Rate: A Clinical Study." Journal of Pharmacy and Bioallied Sciences 16, Suppl 1 (2024): S507—S509. http://dx.doi.org/10.4103/jpbs.jpbs_832_23.

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ABSTRACT Context: The link between oral infections and systemic disease is a well-proven hypothesis in the current literature. This relationship is the result of interaction between periodontal microbe that triggers inflammatory processes leading to the secretion of cytokines and other mediators of inflammation resulting in the systemic effects of pathogenesis. Materials and Methods: In this study, erythrocyte sedimentation rate (ESR), probing pocket depth, plaque index, gingival index, and the parameters were assessed initially and 1 month after scaling and root planing (SRP). Statistical Ana

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Emulina, Darta Elizabete, Iveta Abola, Anda Brinkmane, et al. "The Impact of IL1B rs1143634 and DEFB1 rs11362 Variants on Periodontitis Risk in Phenylketonuria and Type 1 Diabetes Mellitus Patients in a Latvian Population." Diagnostics 14, no. 2 (2024): 192. http://dx.doi.org/10.3390/diagnostics14020192.

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Objectives: Periodontitis is a multifactorial disease that affects approximately 11% of the global population. The objective of this study was to examine whether, among individuals with phenylketonuria and type 1 diabetes mellitus, those with the IL1B rs1143634 and/or DEFB1 rs11362 genetic variants exhibit a higher periodontitis risk compared to healthy controls. Materials and Methods: In all, 43 phenylketonuria patients (aged 12–53), 28 type 1 diabetes mellitus patients (aged 11–40), and 63 healthy controls (aged 12–53) were included. The evaluation of periodontitis risk was conducted using t

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Alqahtani, Saeed, Bruce Cooper, Claire A. Spears, Christa Wright, and Jonathan Shannahan. "Electronic nicotine delivery system-induced alterations in oral health via saliva assessment." Experimental Biology and Medicine 245, no. 15 (2020): 1319–25. http://dx.doi.org/10.1177/1535370220941258.

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Use of electronic nicotine delivery systems (ENDS) is becoming increasingly prevalent. ENDS aerosols contain a variety of toxic components that may adversely impact health. Although exposure to traditional cigarette smoke is a risk factor for periodontal disease, the effects of ENDS on oral health have not been adequately examined. To evaluate potential oral health effects associated with ENDS use, a pilot study was performed with 14 current ENDS users and 16 never tobacco users. Participants completed questionnaires about their ENDS use and overall health. Saliva samples were assessed for dif

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Kumar, Gayathri, Deepa Ponnaiyan, Harinath Parthasarathy, Anupama Tadepalli та Suresh Veeramani. "Evaluation of Endocan and Tumor Necrosis Factor-α as Inflammatory Biomarkers in Type 2 Diabetes and Periodontal Disease". Genetic Testing and Molecular Biomarkers 24, № 7 (2020): 431–35. http://dx.doi.org/10.1089/gtmb.2020.0037.

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Dămășaru, Maria Simona, Mariana Păcurar, Mihaela Mariș, Elena Dămășaru, Marius Mariș, and Cornelia Mariana Tilinca. "Implications of type 1 diabetes mellitus in the etiology and clinic of dento-maxillary anomalies - questionnaire-based evaluation of the dentists’ opinion." Medicine and Pharmacy Reports 98, no. 1 (2025): 135–43. https://doi.org/10.15386/mpr-2822.

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Background and aims. Type 1 diabetes is one of the most common chronic childhood diseases, which can be diagnosed at any age, with implications on the general development, but also on the craniofacial structure. It is widely speculated that diabetes occurs when inherited genetic characteristics are triggered by environmental factors. Oral pathology is complex and it includes a series of clinical entities: dental caries, periodontal disease, dento-maxillary anomalies, diseases of the oral mucosa, which implies a significant responsibility for the doctor, but also for society. This study aims to

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P S, Samyuktha, and Dr Naveen Kumar M. "Evaluation of Association Between High Frenal Attachment and Severity of Midline Diastema." Journal of Advanced Zoology 44, S7 (2023): 316–21. http://dx.doi.org/10.17762/jaz.v44is7.2742.

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Introduction: A "midline diastema" arises when there is a space of more than 0.5 millimeters between the proximal surfaces of two consecutive teeth. There is usually open space between the two central incisors. Depending on its width, a midline diastema can make speaking difficult and look unsightly. Genetic factors, large tongues, improper tongue positioning during rest or function, microdontia or hypodontia of upper lateral incisors, extra teeth between upper central incisors, particularly mesiodens, aberrant frenal attachment, periodontal disease, and extra teeth are some of the multifactor

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Adamus, Aleksandra, Julia Cabon, Martyna Mrożek, et al. "Analysis of the bacterial flora of periodontal pockets and evaluation of the diagnostic value and the validity of using the PET test in the detection of Sockransky’s red complex pathogens at various stages and degrees of periodontitis." Journal of Education, Health and Sport 12, no. 8 (2022): 1124–35. http://dx.doi.org/10.12775/jehs.2022.12.08.096.

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Introduction: In microbiological diagnostics, a significant role is played by the PET test based on a polymerase chain reaction developed thanks to medical engineering methods, which, by amplifying specific fragments of genetic material, enables the identification of microorganisms. As a consequence, it is possible to quantify and qualify a sample of biological material under study, which has found application in the diagnosis and treatment of periodontitis. Aim:The following paper shows the validity of carrying out the PET test in people with clinically diagnosed chronic periodontitis w

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Yacoub, Abdulraheem, and Gauranga Mahalwar. "Dentist to Oncologist: Gingival Hyperplasia in AML Accompanied By Periodontal Infection- Case Report." Blood 128, no. 22 (2016): 5187. http://dx.doi.org/10.1182/blood.v128.22.5187.5187.

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Abstract Introduction: Gingival hyperplasia is one of the earliest findings in AML (AFB subtypes M4 and M5). It represents a 5% frequency as the initial presenting complication of AML. Hyperplasia is believed to be due to leukemic infiltration or a secondary inflammatory response to local irritation of preexisting periodontal disease, or both. An impaired immune system following cellular dysplasia can progress to gingivostomatitis and periodontal infection (mainly due to Streptococci, gram negatives, herpes simplex, candida or rarely due to stomatococcus and aerococcus). Induction chemotherapy

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Adamus, Aleksandra, Julia Cabon, Martyna Mrożek, et al. "Analysis of the bacterial flora of periodontal pockets and evaluation of the diagnostic value and the validity of using the PET test in the detection of Sockransky's red complex pathogens at various stages and degrees of periodontitis - discussion of selected clinical cases." Journal of Education, Health and Sport 12, no. 8 (2022): 1124–35. https://doi.org/10.12775/JEHS.2022.12.08.096.

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<strong>Adamus Aleksandra, Cabon Julia, Mrożek Martyna, Rudzińska Iwona, Sekuła Sylwia, Wilk Anna, Wierucka-Młynarczyk Beata</strong><strong>. Analysis of the bacterial flora of periodontal pockets and evaluation of the diagnostic value and the validity of using the PET test in the detection of Sockransky’s red complex pathogens at various stages and degrees of periodontitis - discussion of selected clinical cases. Journal of Education, Health and Sport. 2022;12(8):1124-1135. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.08.096</strong> <strong>https://apcz.umk.pl/JEHS/art

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Cenzato, Niccoló, Anna Nobili, and Cinzia Maspero. "Prevalence of Dental Malocclusions in Different Geographical Areas: Scoping Review." Dentistry Journal 9, no. 10 (2021): 117. http://dx.doi.org/10.3390/dj9100117.

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The World Health Organization (WHO) considers malocclusion one of the most important oral health problems, after caries and periodontal disease. Its prevalence is highly variable and is estimated to be between 39% and 93% in children and adolescents. Due to the importance of malocclusions in dentistry, the aim of our review is to assess the frequency of malocclusions among different geographical regions. A literature research was performed through the Pubmed, Medline, Scopus, Web of Science, LILACS, Open Grey and Cochrane Library databases. The “PRISMA” guidelines were used for the following r

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Papadopoulou, Erofili, Maria Kouri, Anastasia Andreou, et al. "Challenges in Differential Diagnosis of Diffuse Gingival Enlargement: Report of Two Representative Cases and Literature Review." Dentistry Journal 12, no. 12 (2024): 403. https://doi.org/10.3390/dj12120403.

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Background/Objectives: The etiology of diffuse gingival enlargement is multifactorial, and the definitive diagnosis may be challenging. To highlight the nuances of the differential diagnosis, we present two cases of generalized gingival overgrowth and discuss the diagnostic dilemmas. Case description: In the first case, an 82-year-old male with a medical history of hypertension and prostatitis had a chief complaint of symptomatic oral lesions of a 20-day duration, accompanied by fever and loss of appetite. The clinical examination revealed diffusely enlarged, hemorrhagic, and focally ulcerativ

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Khijmatgar, Shahnawaz, Giridhar Belur, Rajesh Venkataram, et al. "Oral Candidal Load and Oral Health Status in Chronic Obstructive Pulmonary Disease (COPD) Patients: A Case-Cohort Study." BioMed Research International 2021 (September 11, 2021): 1–8. http://dx.doi.org/10.1155/2021/5548746.

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Objective. The objective of this study was to determine the candidal load of the patients with Chronic Obstructive Pulmonary Disease (COPD) and evaluate the oral health status of subjects with COPD. Material and Methods. N = 112 COPD subjects and N = 100 control subjects were included in the study. The selection of COPD cases was confirmed based on the set criteria from the American College of Physicians. The oral health status was assessed as per WHO criteria to determine the score of decayed, missing, and filled teeth (DMFT), significant caries index (SiC), community periodontal index and tr

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Costa, E., C. Campinho Ferreira, A. M. Gomes Correia, et al. "AB1859 CERVICAL INVOLVEMENT IN CALCIUM PYROPHOSPHATE DEPOSITION DISEASE - DISEASE SPECTRUM." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 2157.2–2158. http://dx.doi.org/10.1136/annrheumdis-2023-eular.5740.

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BackgroundCalcium pyrophosphate deposition disease (CPPD) is microcrystalline arthropathy that affect space joints and fibrocartilage, leading to inflammation and structural damage. CPPD affects predominantly the appendicular skeleton. For this reason, CPPD has several pseudonyms such as pseudogout, pseudo-rheumatoid arthritis, and pseudo-osteoarthritis. The involvement of the axial skeleton is less common or recognized but may have a broad spectrum of clinical presentations.ObjectivesTo describe the clinical spectrum of axial manifestations of CPPD.MethodsCase report and discussion.Results1–A

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S, Dr Prashanthi, Dr Reshma M, Dr Arun Kumar Prasad P, Dr Esther Nalini H, and Dr Renuka Devi R. "Genetic polymorphisms in periodontal disease." International Journal of Applied Dental Sciences 7, no. 3 (2021): 252–57. http://dx.doi.org/10.22271/oral.2021.v7.i3d.1310.

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N/A. "Genetic Predisposition to Periodontal Disease." Biological Therapies in Dentistry 18, no. 06 (2003): 024. http://dx.doi.org/10.2310/7040.2003.35476.

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Taba Jr, Mario, Sergio Luis Scombatti de Souza, and Viviane Casagrande Mariguela. "Periodontal disease: a genetic perspective." Brazilian Oral Research 26, spe1 (2012): 32–38. http://dx.doi.org/10.1590/s1806-83242012000700006.

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