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Journal articles on the topic 'Periodontal disease'
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Marjanović, D., Z. Anðelković, N. Videnović, et al. "MAST CELLS IN PERIODONT PERIODONTAL DISEASE DISEASE." Praxis medica 35, no. 2 (2007): 99–102. http://dx.doi.org/10.70949/pramed200702210m.
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<p>Periodontal disease is a chronic inflammatory disease that is largely attributable to infections with gram-negative bacteria and is characterised by both gingival inflammation and alveolar bone resorption. Beside macrophages, the second most common cells of the gingival inflammatory infiltrat are mast cells. Mast cells are heterogenous cell population which live from six months to one year. These cells are activated by differnt immunologic and non-immunologic signals. Activated mast cells can secrete a range of substances that regulate angiogenesis, tissue remodeling and wound healing, which include both degradation and synthesis of tissue components. Apart from that, mast cells have an important role in phagocytosis, antigen processing and presentation to T-cells. It is confirmed that gingival mast cells can express matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases, TIMP-1 and TIMP-2. This indicates that mast cells are likely to play an important role in inflammation and tissue degradation in periodontal diseases.</p>
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Freitas, Gabriel Silva Rezende, Letícia Oliveira de Carvalho, Wander Tamura, et al. "Inter-relações entre Doença Periodontal e Doenças Sistêmicas: uma revisão sobre repercussões sistêmicas e implicações para a saúde bucal." Brazilian Journal of Health Review 8, no. 3 (2025): e79426. https://doi.org/10.34119/bjhrv8n3-002.
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A doença periodontal é uma condição inflamatória crônica associada ao biofilme disbiótico e à destruição do periodonto, sendo influenciada por fatores sistêmicos como diabetes mellitus, tabagismo e predisposição genética. Considerando a relevância das interações entre saúde bucal e sistêmica, objetivou-se analisar, por meio de uma revisão de literatura, a associação entre doenças periodontais e condições sistêmicas, investigando os efeitos do tratamento periodontal em desfechos clínicos gerais. Para tanto, procedeu-se à busca de estudos na base de dados PubMed, realizada em abril de 2025, utilizando os descritores “Periodontal disease AND Systemic disease”. Foram incluídos 13 artigos publicados nos últimos cinco anos, em inglês, com textos completos, que abordaram o impacto de tratamentos periodontais não cirúrgicos em doenças sistêmicas, como diabetes mellitus, artrite reumatoide e doença renal crônica. Desse modo, observa-se que a maioria dos estudos demonstrou que as intervenções periodontais, isoladas ou associadas a terapias adjuvantes como melatonina, fototerapia e suplementos, promoveram melhorias significativas nos parâmetros periodontais e nos marcadores sistêmicos. No entanto, alguns trabalhos não evidenciaram benefícios sistêmicos expressivos. Conclui-se que o tratamento periodontal pode impactar positivamente a saúde sistêmica, reforçando a importância da integração entre a odontologia e a medicina na abordagem clínica interdisciplinar do paciente.
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Nunes, Camilla Magnoni Moretto, Camila Lopes Ferreira, Daniella Vicensotto Bernardo, Andréa Carvalho De Marco, Mauro Pedrine Santamaria, and Maria Aparecida Neves Jardini. "Chronic kidney disease and periodontal disease. Case report." Brazilian Dental Science 21, no. 1 (2018): 133. http://dx.doi.org/10.14295/bds.2018.v21i1.1498.
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<p>Chronic renal disease promotes a decrease on kidneys filterability and nitrogen products accumulation on blood, electrolyte and system endocrine functions imbalance. Among the many clinical manifestations of chronic renal failure (CRF) in the oral cavity, there are: dry mouth, uremic stomatitis, radiographic changes in maxillary and jaw bones and accumulation of calculus on the teeth that increases levels of periodonto pathogenic microorganisms able to lead a periodontal tissue destruction and also have the potential to act from a distance on other organs, e.g. the kidneys. Thus, it becomes evident that a periodontal treatment of patients suffering from chronic renal failure is crucial for maintaining their general health conditions and a subsequent successful organ transplant.Thus, the objectives of this case report were to highlight how important the periodontal treatment is for chronic renal failure patients and to demonstrate improvements in their clinical condition through the treatment plan proposed herein. A patient with 43 years old carrier generalized moderate chronic periodontitis and CRF was submitted to scaling and root planning sessions, and later surgical access for scaling where the basic treatment not resulted in a resolution of the inflammatory periodontal process. The results obtained from a well-developed periodontal treatment and an effective cooperation of patient showed satisfactory results with periodontal disease process resolution or stabilization.Thus, periodontal treatment and patient compliance were crucial for the improvement of periodontal clinical conditions enabling a future successful renal transplantation.</p><p><strong>Keywords</strong></p><p>Dental care; Periodontal diseases; Renal insufficiency.</p>
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Ledwon, Beata, Andrzej Miskiewicz, Ewa Grabowska, Jan Kowalski, and Renata Górska. "The Relationship between Periodontal Disease and Motor Impairment in the Course of Parkinson’s Disease." Postępy Higieny i Medycyny Doświadczalnej 74 (August 12, 2020): 340–47. http://dx.doi.org/10.5604/01.3001.0014.3516.
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Introduction: The incidence of Parkinson’s disease and the severity of accompanying motor impairment increase significantly with age. The etiopathogenesis and progression of Parkinson’s disease at the molecular level is associated with the production of cytokines and acute phase proteins, which are also typical for inflammatory diseases, such as periodontitis and gingivitis. Objectives: The aim of the study was to assess the correlation between neurological parameters, the indices of periodontal status and systemic parameters of inflammation, as well as their change after treatment. Patients/Methods: The presented study is a retrospective analysis of data obtained from medical histories and patient charts. Charts of 93 patients diagnosed with Parkinson’s disease and periodontal diseases over the period 2015–2017 were selected. Sixty-one of these patients received periodontal treatment: professional scaling, root planning – SRP and periodontal pockets rinsing with 3% H2O2 and constituted a study group. Additionally, the patients were instructed to use a 0.2% chlorhexidine mouthwash. The other 32 patients, who were not periodontally treated, formed a control group. Both groups continued their anti-parkinsonian treatment. Results: The mean pocket depth at the baseline was 4.0 mm (SD 0.9 mm), mean bleeding index was 56.2%, and 63.9% of patients presented tooth mobility grade II or III. A significant correlation between periodontal and neurological parameters was observed at the baseline. After periodontal treatment, an improvement of both periodontal parameters and those related to the Parkinson’s disease was observed in the study group. Those periodontally treated exhibited lower number of anti-parkinsonian medicines, lower number of falls, as well as better results in10-m walk test and timed-up-and-go test, as compared to the control group. The improvement was observed both 3 and 9 months after the end of treatment.
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Hanisch, Marcel, Thomas Hoffmann, Lauren Bohner, et al. "Rare Diseases with Periodontal Manifestations." International Journal of Environmental Research and Public Health 16, no. 5 (2019): 867. http://dx.doi.org/10.3390/ijerph16050867.
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Background: The object of this paper was to provide an overview of rare diseases (RDs) with periodontal manifestations and allocate them to relevant categories. Methods: In ROMSE, a database for “Rare Diseases with Orofacial Involvement”, all 541 entities were analyzed with respect to manifestations of periodontal relevance. Inclusion criteria were periodontally relevant changes to the oral cavity, in accordance with the 2018 version of the Classification of Periodontal and Peri-Implant Diseases and Conditions. Rare diseases were recorded, using the methodology described, and subsequently compared with the Orphanet Classification of Rare Diseases. Results: A total of 76 RDs with periodontal involvement were recorded and allocated in accordance with the Classification of Periodontal and Peri-Implant Diseases and Conditions. Of the 541 RDs analyzed as having known orofacial manifestations, almost 14 percent indicated a periodontally compromised dentition. Conclusions: Around 14 percent of RDs with an orofacial involvement showed periodontally relevant manifestations, which present not only as a result of gingivitis and periodontitis, but also gingival hyperplasia in connection with an underlying disease. Thus, dentists play an important role in therapy and early diagnoses of underlying diseases based on periodontally relevant manifestations.
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ugli, Nishonov Zokhidjon Khayrulla, and Islamova Nilufar Bustanovna. "Periodontal Disease - Symptoms and Treatment." European International Journal of Multidisciplinary Research and Management Studies 5, no. 2 (2025): 116–19. https://doi.org/10.55640/eijmrms-05-02-21.
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Furkhatovich, Farkhatov Sunnatillokhan, and Akhmedov Alisher Astanovich. "Periodontal Disease - Symptoms and Treatment." Journal of Social Sciences and Humanities Research Fundamentals 5, no. 1 (2025): 81–87. https://doi.org/10.55640/jsshrf-05-01-14.
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Periodontal disease is a disease of periodontal tissues of a dystrophic nature. Periodontal tissues include tissues whose main task is to hold the tooth in the jaw bone. These include: the gum; the ligamentous apparatus that holds the tooth — the periodontium; the tooth cement — the outer surface of the tooth covering its root; and the alveolar part of the jaw bone.
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HABIB, ZAHRA M., and J. MOSHY. "PERIODONTAL DISEASE;." Professional Medical Journal 20, no. 02 (2013): 290–95. http://dx.doi.org/10.29309/tpmj/2013.20.02.639.
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Background: Periodontal disease and systemic diseases are inter-related, each influencing one another. Adequateknowledge on periodontal disease among medical doctors will enable them to refer their patients to dentists for timely management. Thisstudy aimed to assess knowledge, awareness and attitudes of medical doctors towards periodontal disease in Dar-es-Salaam, Tanzania.Settings and design: Cross sectional study on medical doctors working at Muhimbili National Hospital in Dar-es-Salaam, Tanzania.Materials and methods: The study involved 151 medical doctors drawn randomly and who are practicing at Muhimbili National Hospitalin Dar-es-Salaam, Tanzania. Data were obtained via a structured questionnaire and included demographic information’s, knowledgeregarding periodontal disease, their awareness and their attitude towards periodontal disease. They were entered into the SPSS statisticalsoftware for analysis. Frequencies and percentages were calculated and association between variables was done using the chi-squaretest. Results: Of the 151 questionnaires administered, 124 were returned (response rate of 82.12%). One hundred and eleven (89.5%)medical doctors believed poor oral hygiene was the main cause of periodontal disease, only 49(39.5%) told their patients to brushproperly, 47(37.9%) believed that there was a bidirectional relationship between periodontal disease and systemic disease and only35(28.2%) referred all patients with systemic diseases to dentists. 34(27.4%) believed that medical doctors have adequate knowledgeregarding periodontal disease and 18(14.5%) believed that the medical curriculum provides enough knowledge regarding periodontaldisease. Conclusions: Medical doctors had inadequate information about periodontal disease and this should be addressed in themedical curriculum so as to enable proper patient management.
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Shirmohammadi, Adileh, Masoumeh Faramarzi, Ashkan Salari, Mehrnoosh Sadighi Shamami, Amir Reza Babaloo, and Zohreh Mousavi. "Effect of non-surgical periodontal treatment on serum albumin levels in patients with chronic periodontitis." Journal of Advanced Periodontology & Implant Dentistry 10, no. 1 (2018): 18–23. http://dx.doi.org/10.15171/japid.2018.004.
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Background. Albumin is a protein whose serum levels decrease in inflammatory conditions such as periodontal diseases. This study was undertaken to evaluate changes in serum albumin levels in patients with and without periodontal diseases prior and subsequent to non-surgical periodontal treatment and its relationship with clinical parameters of periodontal disease.Methods. Twenty patients diagnosed as having chronic periodontitis and 20 periodontally healthy subjects, referring to Tabriz Faculty of Dentistry, were selected. Serum albumin levels and clinical variables of periodontal disease (probing pocket depth, gingival index, bleeding index, clinical attachment level and plaque index) were determined before treatment and three months subsequent to non-surgical periodontal treatment. Data were subjected to descriptive statistical analyses (mean ± SD). Serum levels of albumin and clinical parameters were compared between the two groups with independent-samples t-test. Paired-samples t-test was applied to compare the variables before and after treatment in the case group. Statistical significance was defined at P<0.05.Results. The mean serum albumin level of chronic periodontitis patients (3.62±0.11 mg/dL) exhibited a significantly lower value compared to subjects who were periodontally healthy (4.17±0.29 mg/dL), with the serum albumin levels increasing significantly three months postoperatively (3.78±0.33 mg/dL), approaching the level in subjects who were periodontally healthy (P<0.05).Conclusion. Decreases and increases in serum albumin levels under the effect of periodontal disease and its treatment indi-cated an inverse relationship between the albumin levels of serum and chronic periodontitis.
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Verma, Dr Amit Kumar. "Periodontal Disease with Diabetes or Diabetes Kidney Disease." International Journal of Trend in Scientific Research and Development Volume-3, Issue-1 (2018): 1043–51. http://dx.doi.org/10.31142/ijtsrd19176.
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Sutedjo, Widyawati, Chiquita Prahasanthi, and Daniel Haryono Utomo. "THE UVEITIS – PERIODONTAL DISEASE CONNECTION IN PREGNANCY: CONTROVERSY BETWEEN MYTH AND REALITY." Indonesian Journal of Tropical and Infectious Disease 3, no. 1 (2015): 30. http://dx.doi.org/10.20473/ijtid.v3i1.199.
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Background: Recently, It had been recognized that oral infection, especially periodontal disease are potential contributing factors to a variety of systemic diseases, such as cardiovascular and cerebrovascular diseases, pregnancy problem, diabetes mellitus type 2, etc. However, the adverse effect of periodontal disease toward uveitis still not clearly understood especially if happens during pregnancy. Interestingly, in Indonesia, there is still a myth that pregnant women should not get any dental treatment, therefore, it may deteriorate periodontal disease during pregnancy. Purpose: to explain the possible connection between periodontal disease and uveitis and increasethe awareness of these problems during pregnancy that could be understood by doctor and laymen. Reviews: literatures revealed that dental infection can caused uveitis via metastatic spread of toxin and inflammatory mediators. Additionaly, more recent investigation reported that the neural system may also stimulated by oral infection. In the orofacial regions there's trigeminal nerve complex that also related to the orbital region, thus may also involved in the uveitis pathogenesis. The effects of periodonto pathogens toxins towardimmunocompetent cell and nerves had also been reported by researcher. Moreover, pregnant women are more susceptible to periodontal disease, therefore maintaining oral hygiene and dental monitoring is a mandatory.Conclusion: in woman who susceptible to uveitis, periodontal disease may exacerbate the symptoms especially in pregnancy. Therefore simple explanation about connection of oral infection-systemic diseases especially in pregnancy should be widespread among Indonesian people.
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Sharma, Anuj, A. R. Pradeep, N. M. Raghavendra, P. Arjun, and Rahul Kathariya. "Gingival Crevicular Fluid and Serum Cystatin C Levels in Periodontal Health and Disease." Disease Markers 32, no. 2 (2012): 101–7. http://dx.doi.org/10.1155/2012/279295.
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Cystatin C (CSTC) is an inhibitor of cysteine proteinases and could play a protective and regulatory role under inflammatory conditions. The present study was designed to assess the concentration of CSTC in gingival crevicular fluid (GCF) and serum, to find out their association if any, in periodontal health and disease. 30 subjects were selected divided into 3 groups consisting of 10 subjects in each group based on clinical parameters: periodontally healthy group, gingivitis group and chronic periodontitis group, while, chronic periodontitis group after 8 weeks of the treatment (scaling and root planing) constituted after periodontal therapy group. GCF and serum samples were collected from all subjects to estimate the levels of CSTC by ELISA. The mean CSTC concentration in GCF and serum was observed to be the highest in periodontitis group and lowest in periodontally healthy group with intermediate concentration in gingivitis group and after periodontal therapy group. CSTC concentration in GCF and serum increased proportionally with the severity of periodontal disease (from health to periodontitis group) and decreased after treatment. This suggests that CSTC increases with disease progression to prevent further periodontal degeneration and decreases after treatment due to bone metabolic homeostasis. Further, longitudinal prospective studies involving larger population are needed to confirm the findings of present study and to better understand the role of CSTC in the pathogenesis of periodontal diseases.
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Gomes Viana, Mariana Vitória, Júlia Santos Cerqueira, and Regina Lucia Seixas Pinto. "APLICAÇÃO DIAGNÓSTICA DE IMAGENS TRIDIMENSIONAIS (3D) NA DOENÇA PERIODONTAL DIAGNOSTIC APPLICATION OF THREE-DIMENSIONAL IMAGES (3D) IN PERIODONTAL DISEASE." Revista da Faculdade de Odontologia da Universidade Federal da Bahia 50, no. 1 (2020): 57–51. http://dx.doi.org/10.9771/revfo.v50i1.37117.
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A doença periodontal é uma doença altamente prevalente na populaçãomundial e se caracteriza pela destruição progressiva do ligamento periodontale reabsorção da crista óssea alveolar interdental e interradicular. Temcomo fatores etiológicos as bactérias do biofilme que associadas aos fatoresgenéticos e ambientais geram uma resposta inflamatória liberam enzimasproteolíticas e danificam o tecido de suporte dental. A avaliação da perdada inserção periodontal por exame clínico é limitada pelos instrumentosde sondagem e condições anatômicas, portanto, imagens radiográficas sãoinevitáveis para determinar a extensão e a gravidade das lesões, pois a representaçãoespacial do osso alveolar tem um valr altamente significativona Periodontia, uma vez que as decisões terapêuticas e as estimativas a longoprazo do prognóstico se fundamentam nele. O exame de imagem maiscomumente utilizado é através de radiografias convencionais, no entantofornece apenas uma visão bidimensional das estruturas tridimensionais,perdendo assim o valor diagnóstico essencial. A imagem tridimensional ou3D, tem se revelado como uma ferramenta clínica, pelo valor altamente informativo.O objetivo do presente trabalho consiste em realizar uma revisãode literatura sobre a aplicação diagnóstica da tomografia computadorizadade feixe cônico em lesões periodontais. Periodontal disease is characterized by the progressive destruction of theperiodontal ligament and alveolar bone Crest resorption interdentallyand interradicular, its etiological factors that biofilm bacteria associatedwith genetic and environmental factors generate an inflammatory responsethat release proteolytic enzymes and damage the fabric of dental support. The evaluation of periodontal insertion loss by clinical examinationis limited by probing instruments and anatomical conditions, therefore,x-rays are inevitable to determine the extent and severity of injuries,because the space representation of the alveolar bone has a significantrole in Periodontics, since therapeutic decisions and long-term estimatesof prognosis are based on it. The most commonly used imaging methodis through conventional x-rays, however, provides only a two-dimensionalview of the three-dimensional structures, thereby losing the essentialdiagnostic value. 3D image has proved as a clinical tool for highly informativevalue. The purpose of this study is to conduct a review of the literatureabout the intended use of cone beam computed tomography inperiodontal lesions.
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Barros, Sarah Germano Bouzada, Eliziário Cesar de Vasconcelos Leitão, Adelcio de Oliveira Sudário, Maria Aparecida Germano Façanha, Anna Luísa de Castro Mafra, and Camila Almeida Silva. "Hormônios Sexuais Femininos, Menopausa e Doença Periodontal: Uma Revisão de Literatura." Revista JRG de Estudos Acadêmicos 8, no. 18 (2025): e081702. https://doi.org/10.55892/jrg.v8i18.1702.
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Introdução: A periodontite é uma doença periodontal, de origem bacteriana, que mais frequentemente afetam e podem destruir o periodonto. A menopausa ocorre apenas nas mulheres e é definida como amenorreia que dura mais de 12 meses consecutivos, acompanhada de uma falta de estrogênios que pode conduzir à osteoporose. A osteoporose é definida como uma diminuição da densidade mineral óssea, o que enfraquece os ossos, levando à potencial fratura. Objetivo: Evidenciar influência da ação dos hormônios sexuais femininos nas alterações periodontais a partir da menopausa. Materiais e Métodos: Foram selecionados artigos realizados até o ano 2022, sob as palavras-chaves: hormônios sexuais femininos, menopausa, doença periodontal, periodontite e em inglês: “female sex hormones”, “menopause”, “periodontal disease’’ e “periodontitis”. Resultados: Torna-se difícil isolar um fator relacionado com a menopausa que seja diretamente responsável pela doença periodontal. Parece que a acumulação simultânea de muitos fatores de risco, interagindo uns com os outros, tem uma maior influência na progressão da doença periodontal. No entanto, a deficiência de estrogénio ou condições osteoporóticas podem agravar a doença periodontal e promover a recidiva após o tratamento. Conclusão: Cabe ao cirurgião-dentista através de vários dados clínicos, radiográficos e mediado por conhecimentos científicos, avaliar cada paciente individualmente, facultando os recursos terapêuticos para as doenças periodontais durante a fase climatérica
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Gupta, Shipra, Ritin Mohindra, Manisha Ramola, et al. "Convergence of inflammatory response: Salivary cytokine dynamics in coronavirus disease 2019 and periodontal disease." Journal of Indian Society of Periodontology 28, no. 1 (2024): 113–21. http://dx.doi.org/10.4103/jisp.jisp_508_23.
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Abstract: Background: Periodontal disease is associated with immune dysregulation, and cytokines released can add on to the coronavirus disease 2019 (COVID-19)-associated cytokine storm, further worsening the related adverse outcomes. Specific studies investigating cytokine levels in COVID-19 patients with periodontal disease are lacking. Examining the correlation between these conditions could aid in categorizing risk categories, determining referrals, and strengthening oral hygiene protocols. The current study sought to evaluate cytokine levels in the saliva of COVID-19-positive patients with and without periodontal disease. Materials and Methods: Twenty-six COVID-19-positive patients were subjected to periodontal examination, saliva collection, and assessment of cytokine levels through cytokine bead-based multiplex assay, using fluorescence-encoded beads with flow cytometry (BD FACS LSRFortessa). Eleven cytokines were assessed (interleukin [IL] 2, 4, 6, 10, 17A, and interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-α), chemokine ligand 2 (CCL2/monocyte chemoattractant protein-1), C-X-C motif chemokine ligand (CXCL) 8/IL 8, CXCL 9/monokine-induced gamma interferon [MIG]), and CXCL 10 (chemokine IFN-gamma inducible protein 10 kDa). The cytokine levels of the recruited subjects were also compared graphically with the salivary cytokine levels reported in the literature for health, COVID-19, and periodontal disease alone. Results: Out of 26 COVID-19-positive patients, 17 had periodontal disease. Levels of all cytokines were raised in patients with both diseases when compared to values reported in literature for health, periodontal disease alone, or COVID-19 alone. However, there was no statistical difference among the recruited subjects for IL-2, IL-4, IL-6, IL-10, IL-17A, IFN-gamma, TNF-α, CCL2, CXCL 8, and CXCL 10. MIG levels were found to be higher in periodontally healthy, COVID-19-positive subjects (P = 0.01). Conclusions: Periodontal disease might contribute to the COVID-19-induced cytokine storm, potentially amplifying its impact.
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Jasim Khalaf, Salim, Mahdi Salih Hamad, and Entedhar Rifaat Sarhat. "Salivary Biomarkers in Periodontal Diseases: A Review." Tikrit Journal for Dental Sciences 11, no. 1 (2023): 105–8. http://dx.doi.org/10.25130/tjds.11.1.12.
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Saliva represents an important biological material for diagnosis of oral problems. Salivary biomarkers like enzymes, proteins, or oxidative stress are used for early screening of oral diseases and evaluating of disease activity, and also measure the efficacy of therapy, therefore; it is used for determination of periodontal disease activity and prognosis. Salivary biomarkers are potentially important for determining the presence, risk, and progression of periodontal disease, therefore; it is not only reflecting the current status of periodontal diseases but may predict their progression and response to treatment. The prevalence of periodontitis is about 5–15% worldwide. There are some factors that may increase the incidenc e of periodontitis like smoking, obesity, diabetes, and heart diseases. Method of assessing and monitoring periodont al disease must be quick, easy and reliable and should provide important diagnostic information that improves and speeds treatment decisions.
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Cerovic, Olivera, Besir Ljuskovic, and Vladan Kovacevic. "Periodontal disease in relation to some systemic diseases." Serbian Dental Journal 50, no. 4 (2003): 197–201. http://dx.doi.org/10.2298/sgs0304197c.
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Periodontal disease is closely related to the general state of the body because it significantly influences periodontal health, as periodontal health can have an influence on the state of the body. It is known that some systemic diseases can represent a risk factor for periodontal disease such as diabetes, blood disorders and immunodefficient disorders. Reducing defensive efficiency of the body, these diseases enable the onset and the development of periodontal disease. On the other hand, concerning the role of microorganisms in the onset and the development of periodontal disease there is justified suspicion that periodontal infection might endanger general state of the body and cause some systemic diseases, such as cardiovascular, respiratory, eye, renal, skin disease and the diseases of the musculoskeletal system. The awareness of connection between periodontal disease and some systemic diseases is of great significance for the diagnosis and the therapy of periodntal disease and the disorders it may cause.
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Niemiec, Brook A. "Periodontal Disease." Topics in Companion Animal Medicine 23, no. 2 (2008): 72–80. http://dx.doi.org/10.1053/j.tcam.2008.02.003.
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Cavendish, Roberta. "Periodontal Disease." American Journal of Nursing 99, no. 3 (1999): 36–37. http://dx.doi.org/10.1097/00000446-199903000-00032.
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Bencosme, Julie. "Periodontal disease." Nursing 48, no. 7 (2018): 22–27. http://dx.doi.org/10.1097/01.nurse.0000534088.56615.e4.
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Ahearn, David J. "PERIODONTAL DISEASE." Journal of the American Dental Association 133, no. 7 (2002): 809. http://dx.doi.org/10.14219/jada.archive.2002.0283.
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Williams, Ray C. "Periodontal Disease." New England Journal of Medicine 322, no. 6 (1990): 373–82. http://dx.doi.org/10.1056/nejm199002083220606.
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Kina, José Ricardo. "Periodontal Disease." International Journal of Biomedical Investigation 1, no. 1 (2018): 1–2. http://dx.doi.org/10.31531/2581-4745.1000101.
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Torpy, Janet M. "Periodontal Disease." JAMA 299, no. 5 (2008): 598. http://dx.doi.org/10.1001/jama.299.5.598.
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José, Ricardo Kina. "Periodontal Disease." International Journal of Biomedical Investigation 1, no. 1 (2018): 1–2. https://doi.org/10.31531/2581-4745.1000101.
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To establish the treatment or prevention of an illness will always be necessary the eradication of all etiological factors, and/or increase host local resistance and/or improve the overall resistance of the host against all etiologic factors, and/or promote a control of etiological factors at levels below their potential for aggression capable of being inactivate by the host's defensive system to induce health for a long period.
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Joseph, Rosamma, Rajaratnam Krishnan, and Vivek Narayan. "Higher prevalence of periodontal disease among patients with predialytic renal disease." Brazilian Journal of Oral Sciences 8, no. 1 (2015): 14–18. https://doi.org/10.20396/bjos.v8i1.8642321.
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Aim: Periodontal diseases can have a significant effect on the systemic health. Chronic systemic diseases such as renal disease may also influence progression of periodontal disease. The present study assessed the prevalence of periodontal disease among a group of patients with renal disease and compared their periodontal status to that of healthy controls. Methods: 77 patients with different forms of renal disease and 77 healthy controls were examined for oral hygiene status, gingival inflammation, probing pocket depth and clinical attachment loss. The subjects were grouped into three as no/mild, moderate and severe periodontitis. Results: All periodontal parameters were significantly elevated in the case group as compared to controls (p < 0.001). The prevalence and severity of periodontal disease was also significantly higher in the case group (p < 0.001). Conclusions: This study provides evidence for a greater prevalence and severity of periodontal disease among patients with renal disease. The periodontal health of all patients with renal disease needs to be carefully monitored.
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Pallasch, Thomas J. "PERIODONTAL DISEASE AND OTHER DISEASES." Journal of the American Dental Association 140, no. 1 (2009): 16–17. http://dx.doi.org/10.14219/jada.archive.2009.0001.
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Nguyen, Thomas T., Kevin Y. Wu, Maude Leclerc, Hieu M. Pham, and Simon D. Tran. "Cardiovascular Diseases and Periodontal Disease." Current Oral Health Reports 5, no. 1 (2018): 13–18. http://dx.doi.org/10.1007/s40496-018-0165-3.
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Santos, Bruna Rafaela Martins dos, Clarissa Favero Demeda, Eutália Elizabeth Novaes Ferreira da Silva, Maria Helena Marques Fonseca de Britto, Kenio Costa Lima, and Maria Celeste Nunes de Melo. "Prevalence of Subgingival Staphylococcus at Periodontally Healthy and Diseased Sites." Brazilian Dental Journal 25, no. 4 (2014): 271–76. http://dx.doi.org/10.1590/0103-6440201302285.
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Staphylococci are considered members of the transient oral microbiota and are seldom isolated from the oral cavity. The aim of this study was to establish the prevalence of subgingival staphylococci in healthy and periodontal disease sites. Sterile endodontic paper points were used to isolate subgingival staphylococci in periodontally healthy and periodontally diseased sites in 30 adult subjects (n=540 sites). Staphylococcus spp were identified by an automated method and confirmed by conventional biochemical tests. All the samples were identified as coagulase-negative staphylococci. The results were analyzed using Mann-Whitney U, chi-square and Fisher's exact test at 5% significance level. A total of 86.7% of the subjects harbored these microorganisms in 11.7% of their periodontal sites. The most frequently isolated species was S. auricularis, which was isolated from 31.4% of the periodontal sites, followed by S. epidermidis, isolated from 21.4% of them. There was no statistically significant difference between the frequencies of these species isolated either from the healthy and the diseased sites (p>0.153). Although staphylococci are present in the subgingival environment and contribute to the pathogenic synergism involved in periodontal diseases, the results suggest that they do not participate directly in the pathogenesis of these diseases.
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Alquthami, Hind, Abdulaziz M. Almalik, Faisal F. Alzahrani, and Lana Badawi. "Successful Management of Teeth with Different Types of Endodontic-Periodontal Lesions." Case Reports in Dentistry 2018 (May 29, 2018): 1–7. http://dx.doi.org/10.1155/2018/7084245.
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Endodontic-periodontal diseases often present great challenges to the clinician in their diagnosis, management, and prognosis. Understanding the disease process through cause-and-effect relationships between the pulp and supporting periodontal tissues with the aid of rational classifications leads to successful treatment outcomes. In this report, we present several treatment modalities in patients with different endodontic-periodontal lesions. A modification to the new endodontic-periodontic classification, Al-Fouzan’s classification, was also added. The first case was classified as retrograde periodontal disease (i.e., primary endodontic lesion with drainage through the periodontal ligament). The second case was diagnosed as an iatrogenic periodontal lesion caused by root perforation. The third case was diagnosed as an iatrogenic periodontal lesion caused by tooth trauma due to orthodontic treatment. The first two cases were managed with a nonsurgical approach, whereas the third case was managed with nonsurgical and surgical approaches. All patients showed complete healing of soft and hard tissue lesions. A thorough understanding of the disease history and the patient’s signs and symptoms, complete examination with full investigation, and the use of a systematic step-by-step approach in the management of such challenging endodontic-periodontal lesions with regular recall visits were very useful and successful.
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Gonçalves, Gabriela Sumie Yaguinuma, Tayna Natsumi Takakura, Anderson Catelan, Rosalinda Tanuri Zaninotto Venturim, Carolina dos Santos Santinoni, and Christine Men Martins. "Tratar ou extrair? Tratamento de lesão endoperiodontal, um relato de caso clínico." ARCHIVES OF HEALTH INVESTIGATION 9, no. 6 (2020): 535–40. http://dx.doi.org/10.21270/archi.v9i6.4814.
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Introdução: Lesões endoperiodontais são lesões originadas de produtos inflamatórios encontrados tanto em periodonto quanto em polpa. Tais lesões podem se originar devido a uma infecção pulpar ou periodontal. Visando o prognóstico favorável, é imprescindível o conhecimento da etiologia, realização do correto diagnóstico e elaboração do plano de tratamento que envolve o tratamento endodôntico precedido do tratamento periodontal. Objetivo: O propósito do presente trabalho foi de relatar um caso clínico de lesão endoperiodontal e o tratamento realizado. Relato de caso clínico: Paciente gênero feminino, 51 anos, compareceu à clínica com uma fístula na região do dente 46, procedeu-se com exame radiográfico, rastreamento de fístula, testes endodônticos e avaliação periodontal. Foi diagnosticada lesão endoperiodontal. Executou-se, então, o tratamento endodôntico em sessões múltiplas, utilizando hidróxido de cálcio como medicação intracanal e o tratamento periodontal concomitante; finalizou-se endodontia obturando-se os canais radiculares. Conclusão: Observou-se, no controle, que a associação de tratamentos foi eficaz e houve melhora significativa do quadro, constatando-se silêncio clínico e sucesso do tratamento. Realizar o tratamento conservador a despeito da exodontia foi a melhor escolha para a paciente.
 Descritores: Endodontia; Periodontia; Polpa Dentária; Periodonto.
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Villalta Mendoza, Fernando Mauricio, Scarlett Maribel Pesántez Correa, Jhonny Leonel González Ortega, Andrea Belén Ochoa Ávila, Christian Daniel Piedra Arpi, and Jorge Antonio Reinoso Ortiz. "Embarazo y enfermedad periodontal: Revisión de la literatura." Research, Society and Development 11, no. 17 (2022): e164111739264. http://dx.doi.org/10.33448/rsd-v11i17.39264.
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Objetivo: El objetivo del estudio es determinar la relación y el impacto que tiene las enfermedades periodontales durante el embarazo tanto para la gestante y el feto. Metodología: Se realizo una búsqueda exhaustiva de la literatura en las bases de datos “PUBMED”, “Science Direct”, “Scopus” y “Ebsco” utilizando las palabras clave: “Pregnancy”, “Periodontal Disease”, “Gingivitis”, “Periodontitis”; donde se pudieron obtener un total de 20 artículos que cumplían con los criterios de inclusión y exclusión. Resultados: La enfermedad periodontal presenta consecuencias graves en el desarrollo del feto debido al desbalance entre la inmunidad del paciente y la presencia de microrganismos periodonto patógenos. Conclusión: La enfermedad periodontal es un factor de riesgo a ser tomado en cuenta durante el embarazo, su diagnóstico precoz y eficaz tratamiento permitirá evitar cualquier tipo de complicación a corto o largo plazo.
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Soldati, Kahena Rodrigues, Lorena Silva Gutierrez, Giovana Anovazzi, Raquel Mantuaneli Scarel-Caminaga, and Daniela Leal Zandim-Barcelos. "Impact of smoking on protein levels of beta-defensins in periodontal disease." Brazilian Dental Journal 33, no. 4 (2022): 79–86. http://dx.doi.org/10.1590/0103-6440202204685.
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Abstract Antimicrobial peptides (AMPs) are important components of the host response against invading pathogens. In addition to their direct antimicrobial activity, they can also participate in the immune system modulation. However, the role of AMPs in the etiopathogenesis of periodontal disease and the risk factors that may influence their expression in the oral cavity are not fully understood. The aim of this study was to determine the impact of smoking on beta-defensin (hBD) 1 and 2 levels analyzing samples from periodontitis patients. Fifty patients with periodontitis, 25 smokers and 25 non-smokers, and 20 periodontally healthy patients were recruited. After periodontal clinical evaluation, gingival crevicular fluid (GCF) samples were collected from healthy sites of patients without periodontal disease and from healthy and diseased sites of patients with periodontitis. Peptides quantification was performed by sandwich ELISA technique. Smokers showed reduced GCF hBD 1 levels and increased hBD 2 levels compared to non-smokers in diseased sites (p <0.05). Higher levels of hBD 1 were observed in healthy sites of patients without periodontal disease than in healthy sites of patients with periodontitis (p<0.0001). Diseased sites of non-smokers presented higher levels of hBD 2 than healthy sites (p <0.05). These results reveal that protein levels of hBDs 1 and 2 can be impaired by cigarette smoking in the presence of periodontal disease.
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Mhaske, Maya, Mithila Kakade, Sushma Belkhede, and Kalyani Reddy. "Periodontal Disease and Adverse Pregnancy Outcomes." International Journal of Science and Research (IJSR) 10, no. 6 (2021): 213–17. https://doi.org/10.21275/sr21531150558.
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Mankar, Kamalkishor, and Pranjali Bawankar. "Mechanisms Linking Periodontal Disease and Cardiovascular Disease: A Review and Update." Galore International Journal of Health Sciences and Research 6, no. 2 (2021): 13–24. http://dx.doi.org/10.52403/gijhsr.20210403.
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Aim: To present review of current literature regarding association between periodontal and cardiovascular diseases and the mechanisms involved in the association. Materials and Methods: Thorough search was carried out on PUBMED, MEDLINE databases and Google on the association between periodontal disease and cardiovascular diseases and the mechanisms involved selected literature included review articles, observational studies, case control studies, randomized control trials and meta-analysis. Priority was placed on papers published within last 10 years. Brief description of periodontal disease and atherosclerosis underlying pathophysiology has also been included. Results and Conclusion: Preponderance of data appears to support the concept that a potential link does exist between periodontal disease and CVD independent of confounding factors. Interventional trials have shown that periodontal therapy is associated with reduction in surrogate markers of atherosclerotic cardiovascular disease. Prospective interventional studies are required to determine the exact link between PD and CVD as well as to evaluate whether periodontal treatment may reduce the risk of developing CVD. Clinical Significance Pre assessment of developing cardiovascular disease using biomarkers can help in diagnosis of developing or worsening periodontal diseases at earlier stages and can aid in providing screening services and advice to seek immediate dental care. Keywords: Coronary Artery Disease, Chronic Periodontitis, Interrelationship, Periodontal disease, Systemic conditions.
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Furuta, Michiko, Yoshihiro Shimazaki, Shunichi Tanaka, et al. "Gender-Specific Associations of Serum Antibody toPorphyromonas gingivalisand Inflammatory Markers." BioMed Research International 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/897971.
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It remains unclear whether serum antibody titer againstPorphyromonas gingivalis(Pg) and inflammatory components lead to periodontal deterioration in each gender, as periodontal and systemic status is influenced by gender. The present study investigates the gender-specific probable effects of titer againstPgand inflammatory markers on periodontal health status in a longitudinal study. A retrospective study design was used. At two time points over an 8-year period (in 2003 and 2011), 411 individuals (295 males with a mean age of 57.6 ± 11.2 years and 116 females with a mean age of 59.2 ± 10.3 years) were surveyed. Periodontal status, serum antibody titer againstPg, and high-sensitive C-reactive protein (hsCRP) were evaluated. Poisson regression analyses revealed that the elevated titer againstPgand hsCRP significantly predicted the persistence of periodontal disease 8 years later in females with periodontal disease in 2003. Elevated hsCRP was significantly associated with the incidence of periodontal disease 8 years later in females who were periodontally healthy in 2003. Males had a weaker association among titer againstPg, inflammatory markers, and periodontal disease. These findings suggest that immune response toPginfection in addition to inflammatory components affects periodontal deterioration in females.
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Tobita, Morikuni, and Hiroshi Mizuno. "Periodontal Disease and Periodontal Tissue Regeneration." Current Stem Cell Research & Therapy 5, no. 2 (2010): 168–74. http://dx.doi.org/10.2174/157488810791268672.
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Tsuchida, Sachio, Mamoru Satoh, Masaki Takiwaki, and Fumio Nomura. "Current Status of Proteomic Technologies for Discovering and Identifying Gingival Crevicular Fluid Biomarkers for Periodontal Disease." International Journal of Molecular Sciences 20, no. 1 (2018): 86. http://dx.doi.org/10.3390/ijms20010086.
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Periodontal disease is caused by bacteria in dental biofilms. To eliminate the bacteria, immune system cells release substances that inflame and damage the gums, periodontal ligament, or alveolar bone, leading to swollen bleeding gums, which is a sign of gingivitis. Damage from periodontal disease can cause teeth to loosen also. Studies have demonstrated the proteomic approach to be a promising tool for the discovery and identification of biochemical markers of periodontal diseases. Recently, many studies have applied expression proteomics to identify proteins whose expression levels are altered by disease. As a fluid lying in close proximity to the periodontal tissue, the gingival crevicular fluid (GCF) is the principal target in the search for periodontal disease biomarkers because its protein composition may reflect the disease pathophysiology. Biochemical marker analysis of GCF is effective for objective diagnosis in the early and advanced stages of periodontal disease. Periodontal diseases are also promising targets for proteomics, and several groups, including ours, have applied proteomics in the search for GCF biomarkers of periodontal diseases. This search is of continuing interest in the field of experimental and clinical periodontal disease research. In this article, we summarize the current situation of proteomic technologies to discover and identify GCF biomarkers for periodontal diseases.
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Abd El Moaty Sheha, Eman Ali, Hanan Elzeblawy Hassan, and Wafaa Mostafa Ahmed Gamel. "Association between Pre-pregnant Overweight and Obesity and Periodontal Disease during Pregnancy: A Cross Sectional Study." International Journal of Studies in Nursing 3, no. 1 (2017): 1. http://dx.doi.org/10.20849/ijsn.v3i1.207.
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Background: Obesity is considered а noteworthy public health issue in both developed & developing countries. Among the 1.5 billion overweight individuals worldwide, 300 million of them were obese women. In the general, the prevalence of maternal obesity has increased 60% in the previous two decades with nearly 1 in 3 women now entering pregnancy obese. Also, the periodontаl disease has been observed to be prevalent in pregnant women with the prevalence ranging from 20% to more than 50%, especially economically disadvantaged women.Aim: explore the relation between pre-pregnant overweight and obesity with periodontal disease during pregnancy.Subjects & Methods: cross-sectional study among 400 pregnant women were booked in the high-risk obstetric departments and the antenatal outpatient clinics at governmental general hospitals in El-Fayoum City and governmental university hospital in El-Mansoura city.Results: The mean age of pregnant women was 29.9 ± 6.2 with increase the prevalence of periodontal disease in pregnant women (83.5%). Statistically significant correlation was found between prenatal weight and periodontаl disease during pregnancy (p ≤ 0.0001) with increasing the prevalence of periodontal disease in prenatal obese women (53.2%) and over weight (39.7%) were observed in women who were in their 3rd trimester (р = 0.011). Increase prevalence of periodontal with poor oral hygiene and sedentary activity.Conclusion: increased pre-pregnancy obesity & overweight are positively correlated with periodontal disease prevalence among pregnant women, and Pregnancy itself may also be associated with аn increased risk of periodontal disease.Recommendations: Activating the role of the maternity and community health nurse in branches of Obstetrics and antenatal clinics to enhance pregnant women's knowledge regarding oral health risks of obesity & overweight.
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Tardelli, Juliana Peregrino de Brito, Ana Tatiana Gonzalez de Melo, Francisco Franceschini Neto, Ennyo Sobral Crispim da Silva, and Naiara de Oliveira Farias. "Mecanismos patogênicos da doença periodontal – Revisão de literatura." Research, Society and Development 14, no. 2 (2025): e2714248204. https://doi.org/10.33448/rsd-v14i2.48204.
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Introdução: Alterações do periodonto, causadas pelo biofilme dental, acarretarão em gengivites e/ou periodontites. As reações inflamatórias e imunes são seus achados predominantes. Tal reação é visível clínica e microscopicamente no periodonto afetado. O objetivo do presente estudo é compreender os mecanismos que regem a patogênese das doenças periodontais visto que são fatores decisivos na tomada de medidas eficazes no controle da doença. Fundamentação Teórica e Discussão: Os tecidos periodontais saudáveis demonstram sinais estruturais e fisiológicos de proteção. Quando componentes bacterianos interagem com o epitélio e conseguem penetrar no tecido conjuntivo, inicia-se uma resposta imune-inflamatória do hospedeiro. Se o desafio microbiano permanece inalterado, o processo inflamatório irá aumentar na região. As condições dentro do biofilme dentário que está se formando começam a favorecer a sucessão de espécies bacterianas e levar a alterações micro e macroscópicas dos tecidos periodontais, que serão resultado da interação entre os micro-organismos presentes neste biofilme e os tecidos e as células inflamatórias do hospedeiro. Metodologia: Revisão narrativa de literatura sobre os mecanismos imuno-biológicos que envolvem a patogênese da doença periodontal. A busca dos artigos foi realizada nas bases de dados PubMed, Bireme e Scielo e os seguintes descritores: pathogenesis, dental biofilm, periodontal disease. Conclusão: O biofilme dentário é fundamental para o início do processo patológico. Ele por si só não explica a variedade dos estágios da doença. De forma que questões sobre a suscetibilidade imunológica do indivíduo podem ser a complementação da resposta. Assim, o planejamento do tratamento periodontal deve ser pautado no embasamento científico.
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Tsuchida, Sachio. "Proteome Analysis of Molecular Events in Oral Pathogenesis and Virus: A Review with a Particular Focus on Periodontitis." International Journal of Molecular Sciences 21, no. 15 (2020): 5184. http://dx.doi.org/10.3390/ijms21155184.
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Some systemic diseases are unquestionably related to periodontal health, as periodontal disease can be an extension or manifestation of the primary disease process. One example is spontaneous gingival bleeding, resulting from anticoagulant treatment for cardiac diseases. One important aspect of periodontal therapy is the care of patients with poorly controlled disease who require surgery, such as patients with uncontrolled diabetes. We reviewed research on biomarkers and molecular events for various diseases, as well as candidate markers of periodontal disease. Content of this review: (1) Introduction, (2) Periodontal disease, (3) Bacterial and viral pathogens associated with periodontal disease, (4) Stem cells in periodontal tissue, (5) Clinical applications of mass spectrometry using MALDI-TOF-MS and LC-MS/MS-based proteomic analyses, (6) Proteome analysis of molecular events in oral pathogenesis of virus in GCF, saliva, and other oral Components in periodontal disease, (7) Outlook for the future and (8) Conclusions. This review discusses proteome analysis of molecular events in the pathogenesis of oral diseases and viruses, and has a particular focus on periodontitis.
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Nair, Soumya, Mohamed Faizuddin, and Jayanthi Dharmapalan. "Role of Autoimmune Responses in Periodontal Disease." Autoimmune Diseases 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/596824.
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Periodontal diseases are characterized by localized infections and inflammatory conditions that directly affect teeth supporting structures which are the major cause of tooth loss. Several studies have demonstrated the involvement of autoimmune responses in periodontal disease. Evidences of involvement of immunopathology have been reported in periodontal disease. Bacteria in the dental plaque induce antibody formation. Autoreactive T cells, natural killer cells, ANCA, heat shock proteins, autoantibodies, and genetic factors are reported to have an important role in the autoimmune component of periodontal disease. The present review describes the involvement of autoimmune responses in periodontal diseases and also the mechanisms underlying these responses. This review is an attempt to throw light on the etiopathogenesis of periodontal disease highlighting the autoimmunity aspect of the etiopathogenesis involved in the initiation and progression of the disease. However, further clinical trials are required to strengthen the role of autoimmunity as a cause of periodontal disease.
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Kalhan, Ashish Chetan, Mun Loke Wong, Finbarr Allen, and Xiaoli Gao. "Periodontal disease and systemic health: An update for medical practitioners." Annals of the Academy of Medicine, Singapore 51, no. 9 (2022): 567–74. http://dx.doi.org/10.47102/annals-acadmedsg.2021503.
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Introduction: Chronic periodontal disease is a highly prevalent dental condition affecting tooth-supporting tissues. Scientific evidence is accumulating on links between periodontal disease and various systemic conditions. This narrative review provides a holistic yet succinct overview that would assist medical practitioners to deliver integrated care for better clinical outcomes. Method: Scientific evidence on associations between periodontal disease and systemic conditions was synthesised and critically appraised. Key findings of latest prospective cohort studies, randomised clinical trials, and meta-analysis were closely assessed and compiled. Results: A bidirectional relationship has been established, indicating that diabetes and periodontal disease are closely linked and amplify one another, if not successfully controlled. Existing evidence also supports the associations of periodontal disease with cardiovascular diseases and adverse pregnancy outcomes. Successful treatment of periodontal disease and dental prophylaxis has been shown to improve clinical outcomes in these systemic conditions. Other systemic conditions associated with periodontal disease include respiratory diseases, Alzheimer’s disease, rheumatoid arthritis and chronic kidney disease. Although the underlying mechanisms remain to be fully elucidated, it is generally accepted that the inflammatory burden of chronic periodontal disease has an important systemic impact. Conclusion: Oral-systemic links are multifaceted and complex. While evidence linking periodontal disease with a variety of systemic conditions is still emerging, the nature of the relationship is becoming clearer. The updated understanding of these associations warrants the attention of medical experts and policymakers for a concerted effort to develop a patient-centric, integrated model for the treatment of comorbid dental and medical conditions. Keywords: Cardiovascular diseases, dentistry, diabetes, oral health, periodontal diseases, systemic diseases
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Khuller, Nitin, P. Basavaraj, and KT Chandrasheker. "Periodontic-Endodontic Interrelationship – A Review." Journal of Oral Health and Community Dentistry 4, Spl (2010): 4–6. http://dx.doi.org/10.5005/johcd-4-spl-4.
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ABSTRACT Pulpal and periodontal problems are responsible for more than 50% of tooth mortality today. There is general agreement today that the vast majority of pulpal and periodontal lesions are a result of bacterial infection. Under which conditions and especially in which direction spread of the disease occurs in the pulpo-periodontal continuum remains a matter of controversy. Diagnosis is complicated by the fact that these diseases are too frequently viewed as independent entities when recognition of their interrelationship is critical to successful resolution & treatment of these lesions often requires combined periodontic & endodontic therapy
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Amalia, Martina, Florance Rohani Gultom, and Suryani Hanum. "Tingkat pengetahuan pegawai PLN Lubuk Pakam tentang kaitan penyakit Periodontal dan kesehatan sistemik." Tropical Public Health Journal 3, no. 2 (2023): 97–104. http://dx.doi.org/10.32734/trophico.v3i2.13271.
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Several studies have revealed that there is a relationship between periodontitis and systemic diseases such as cardiovascular disease, diabetes mellitus, pregnancy, and respiratory disease. This is because periodontal infections act as foci of infection for systemic disease. The study aimed to assess the knowledge level of periodontal disease associated with systemic conditions and diseases in PLN Lubuk Pakam employees. The study aimed to assess the knowledge level of periodontal disease associated with systemic conditions and diseases in PLN Lubuk Pakam employees. The number of respondents was as many as 129 people using total sampling, then respondents filled out the questionnaire. The tests used are validity tests, reliability tests, and descriptive statistical analysis. The description of the level of knowledge of PLN Lubuk Pakam employees about periodontal disease is moderate (64.9%). The description of the level of knowledge of PLN Lubuk Pakam employees about periodontal disease associated with systemic conditions and diseases is less (49.5%). It is necessary to educate or educate the public about the link between periodontal disease and systemic diseases and conditions. The majority level of knowledge of PLN Lubuk Pakam employees about periodontal disease associated with systemic conditions and diseases is less.
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Kitamura, Mineaki, Yasushi Mochizuki, Yasuyoshi Miyata, et al. "Pathological Characteristics of Periodontal Disease in Patients with Chronic Kidney Disease and Kidney Transplantation." International Journal of Molecular Sciences 20, no. 14 (2019): 3413. http://dx.doi.org/10.3390/ijms20143413.
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Chronic kidney disease (CKD) is recognized as an irreversible reduction of functional nephrons and leads to an increased risk of various pathological conditions, including cardiovascular disease and neurological disorders, such as coronary artery calcification, hypertension, and stroke. In addition, CKD patients have impaired immunity against bacteria and viruses. Conversely, kidney transplantation (KT) is performed for patients with end-stage renal disease as a renal replacement therapy. Although kidney function is almost normalized by KT, immunosuppressive therapy is essential to maintain kidney allograft function and to prevent rejection. However, these patients are more susceptible to infection due to the immunosuppressive therapy required to maintain kidney allograft function. Thus, both CKD and KT present disadvantages in terms of suppression of immune function. Periodontal disease is defined as a chronic infection and inflammation of oral and periodontal tissues. Periodontal disease is characterized by the destruction of connective tissues of the periodontium and alveolar bone, which may lead to not only local symptoms but also systemic diseases, such as cardiovascular diseases, diabetes, liver disease, chronic obstructive pulmonary disease, and several types of cancer. In addition, the prevalence and severity of periodontal disease are significantly associated with mortality. Many researchers pay special attention to the pathological roles and clinical impact of periodontal disease in patients with CKD or KT. In this review, we provide information regarding important modulators of periodontal disease to better understand the relationship between periodontal disease and CKD and/or KT. Furthermore; we evaluate the impact of periodontal disease on various pathological conditions in patients with CKD and KT. Moreover, pathogens of periodontal disease common to CKD and KT are also discussed. Finally, we examine the importance of periodontal care in these patients. Thus, this review provides a comprehensive overview of the pathological roles and clinical significance of periodontal disease in patients with CKD and KT.
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Penlington, L., and Z. Faixová. "Periodontal Disease in Association with Systemic Diseases in the Dog." Folia Veterinaria 63, no. 4 (2019): 1–8. http://dx.doi.org/10.2478/fv-2019-0031.
Full textAbstract:
Abstract Periodontal disease (PD) is the second most common disease affecting dogs in UK veterinary practices. Veterinary and human literature suggests that periodontal disease may be associated with bacteraemia and a chronic, systemic release of inflammatory mediators which produce direct or immune-mediated changes elsewhere in the body. Thirty canine periodontal patient’s electronic medical histories were analysed for comorbidities. The findings were analysed overall to identify any possible associations. Seventy three percent of these dogs had comorbidities, most commonly haematopoietic, cardiovascular, musculoskeletal and hepatic systems were involved. The most prevalent comorbidities were: high liver enzymes, heart murmur, mitral valve disease, and monocytosis. Other interesting comorbidities were: endocarditis, neutrophilia, submandibular lymph node enlargement and arthritis. Periodontal disease patients had a higher prevalence of disease when compared to the disease prevalence data for UK pet dogs in general. Mitral valve disease was over 17 times more likely in the periodontal disease patients. Comorbidity disease prevalence also increased with more severe periodontal disease stages. This study supports an association between periodontal disease and systemic diseases in the dog. Further studies should focus on confirming a cause and effect relationship. Until then, these data may be useful for veterinarians to examine periodontal patients for concurrent diseases and can be used as a tool to promote dental disease prevention to pet owners.
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Shen, Michael T., Betti Shahin, Zhengjia Chen, and Guy R. Adami. "Unexpected lower level of oral periodontal pathogens in patients with high numbers of systemic diseases." PeerJ 11 (July 14, 2023): e15502. http://dx.doi.org/10.7717/peerj.15502.
Full textAbstract:
Background Periodontal disease is associated with systemic conditions such as diabetes, arthritis, and cardiovascular disease, all diseases with large inflammatory components. Some, but not all, reports show periopathogens Porphyromonas gingivialis and Tannerella forsythia at higher levels orally in people with one of these chronic diseases and in people with more severe cases. These oral pathogens are thought to be positively associated with systemic inflammatory diseases through induction of oral inflammation that works to distort systemic inflammation or by directly inducing inflammation at distal sites in the body. This study aimed to determine if, among patients with severe periodontal disease, those with multi-morbidity (or many chronic diseases) showed higher levels of periodontal pathogens. Methods A total of 201 adult subjects, including 84 with severe periodontal disease were recruited between 1/2017 and 6/2019 at a city dental clinic. Electronic charts supplied self-reported diseases and conditions which informed a morbidity index based on the number of chronic diseases and conditions present. Salivary composition was determined by 16S rRNA gene sequencing. Results As expected, patients with severe periodontal disease showed higher levels of periodontal pathogens in their saliva. Also, those with severe periodontal disease showed higher levels of multiple chronic diseases (multimorbidity). An examination of the 84 patients with severe periodontal disease revealed some subjects despite being of advanced age were free or nearly free of systemic disease. Surprisingly, the salivary microbiota of the least healthy of these 84 subjects, defined here as those with maximal multimorbidity, showed significantly lower relative numbers of periodontal pathogens, including Porphyromonas gingivalis and Tannerella Forsythia, after controlling for active caries, tobacco usage, age, and gender. Analysis of a control group with none to moderate periodontal disease revealed no association of multimorbidity or numbers of medications used and specific oral bacteria, indicating the importance of severe periodontal disease as a variable of interest. Conclusion The hypothesis that periodontal disease patients with higher levels of multimorbidity would have higher levels of oral periodontal pathogens is false. Multimorbidity is associated with a reduced relative number of periodontal pathogens Porphyromonas gingivalis and Tannerella forsythia.
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Arellano, María, and Diego Alveal. "Rheumatoid Arthritis and Periodontal Disease. Effects of Periodontal Therapy." International Journal of Medical and Surgical Sciences 2, no. 1 (2018): 377–83. http://dx.doi.org/10.32457/ijmss.2015.003.
Full textAbstract:
During the last years there has been an important increase in the research of associations between periodontal disease and some systemic diseases, looking for a relationship beyond the single epidemiological coincidence. Rheumatoid arthritis (RA) is a chronic systemic disease that damages the bone and connective tissue; despite a low prevalence in the population, the disease has a high morbidity in patients. Rheumatoid Arthritis and Periodontal Disease have common pathophysiological characteristics. A negative influence of periodontal disease over rheumatoid arthritis has been suggested, this has led to increase the interest of studying and elucidating the relationship and possible effects of periodontal therapy on the metabolic control and severity of RA.
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Ricci Volpato, Luiz Evaristo, Ana Thereza de Saboia Campos Neves, Amanda Alves de Oliveira, et al. "A Doença Periodontal no Indivíduo com Fissura Labiopalatina." UNICIÊNCIAS 24, no. 1 (2021): 104–9. http://dx.doi.org/10.17921/1415-5141.2020v24n1p104-109.
Full textAbstract:
A doença periodontal abrange uma gama variada de condições inflamatórias da gengiva, osso e ligamento periodontal dependentes da microbiota do biofilme, de respostas imunes inatas, inflamatórias e adaptativas do hospedeiro e, ainda, fatores individuais genéticos e ambientais. Já as fissuras labiopalatinas são deformidades anatômicas decorrentes da fusão parcial dos processos maxilares nas primeiras semanas de vida intrauterina, especialmente, envolvendo o rebordo alveolar, resultando em alterações no arco dentário e vestíbulo, podendo provocar anomalias dentárias, mal posicionamento dentário e alterações na oclusão, como atresia maxilar e mordida cruzada. Este trabalho tem como objetivo revisar a literatura a respeito da prevalência de alterações periodontais em indivíduos com fissura labiopalatina em diferentes grupos etários e tipos de fissura, bem como comparar os achados com indivíduos sem fissura labiopalatina. Indivíduos com fissura labiopalatina têm sido considerados mais suscetíveis ao desenvolvimento de doença periodontal em função de sua condição anatômica particular e das consequências da fissura para o indivíduo, como muitas vezes o tratamento ortodôntico prolongado, que leva a maior acúmulo de biofilme. Entretanto, conhecimentos mais recentes têm demonstrado que a doença periodontal é uma alteração multifatorial mediada por complexos mecanismos, além do acúmulo de biofilme, como por exemplo, a condição imunológica individual, preponderante para a evolução da doença. Assim, novos estudos são necessários para compreender melhor o comportamento das doenças periodontais nos indivíduos com fissura labiopalatina.
 
 Palavras-chaves: Fenda Labial. Fissura Palatina. Doenças Periodontais.
 
 Abstract
 Periodontal disease covers a wide range of inflammatory conditions of the gingiva, bone and periodontal ligament dependent on the biofilm microbiota, host’s innate, inflammatory and adaptive immune responses, as well as individual genetic and environmental factors. Cleft lip and palate are anatomical deformities resulting from the maxillary processes partial fusion in the first weeks of intrauterine life, especially involving the alveolar ridge, resulting in changes in the dental arch and vestibule, which can also cause dental anomalies, dental malposition and changes in occlusion such as maxillary atresia and crossbite. This work aims to review the literature regarding the prevalence of periodontal changes in individuals with cleft lip and palate in different age groups and types of cleft, as well as to compare the findings with individuals without cleft lip and palate. Individuals with cleft lip and palate have been considered more susceptible to the development of periodontal disease due to their particular anatomical condition and the consequences of the cleft for the individual, such as often the prolonged orthodontic treatment that leads to greater biofilm accumulation. However, more recent knowledge has shown that periodontal disease is a multifactorial alteration mediated by complex mechanisms in addition to the biofilm accumulation, such as, for example, the individual immune condition, which is preponderant for the disease evolution. Thus, further studies are needed to better understand the periodontal diseases behavior in individuals with cleft lip and palate.
 
 Keywords: Cleft Lip. Cleft Palate. Periodontal Diseases.