Dissertations / Theses: 'Periodontal diseases'

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Mancini, Sabrina. "Assessment of a screening test for MMP-8 activity in the diagnosis of periodontal diseases." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0028/MQ40755.pdf.

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Pereira, Sergio Luis da Silva. "Avaliação histologica e histometrica do uso de membramas não reabsorviveis e reabsorviveis em defeitos periodontais cirurgicamente criados em cães." [s.n.], 1999. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290833.

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Orientadores: Enilson Antonio Sallum, Antonio Wilson Sallum
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
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Resumo: O objetivo deste trabalho foi comparar, histológica e histometricamente, o processo de cura de defeitos tipo deiscência tratados pela técnica de regeneração tecidual guiada (RTG) com membranas reabsorvíveis de ácido poliláctico e não reabsorvíveis de politetrafluoroetileno expandido (PTFE-e). Seis cães adultos fêmeas de raça indefinida foram utilizados. Defeitos ósseos tipo deiscência foram criados cirurgicamente nas raízes distais dos terceiros e quartos pré molares mandibulares de ambos os lados e expostos ao acúmulo de placa por 3 meses. Após este período, os defeitos foram aleatoriamente designados para um dos tratamentos: RTG com membrana reabsorvível de ácido poliláctico (Grupo 1), RTG com membrana não reabsorvível de PTFE-e (Grupo 2), raspagem e alisamento radicular manual com acesso cirúrgico (Grupo 3) e não tratado (Grupo 4). Após 3 meses do segundo procedimento cirúrgico, os cães foram sacrificados e os espécimes processados para permitir análise histológica e histométrica, incluindo. os seguintes parâmetros: extensão linear do epitélio sulcular e juncional, adaptação do tecido conjuntivo, novo cemento, extensão vertical do novo osso e nova área óssea. Uma extensão linear de novo cemento estatisticamente superior (P<0.05) foi observada nos sítios tratados pela RTG, independente do tipo de membrana utilizada, em comparação com o Grupo 3. Não houve diferença estatisticamente significante entre o Grupo 1 e 2 em todos os parâmetros avaliados, exceto em relação à área de novo osso. O grupo 1 apresentou uma área de novo osso estatisticamente superior a dos outros grupos (P<0.05). Dentro dos limites deste estudo pôde-se concluir que ambas as membranas foram igualmente efetivas em promover nova formação cementária e que a membrana reabsorvível de ácido poliláctico (não-suturada) providenciou uma maior área óssea em relação à membrana não reabsorvível de PTFE-e
Abstract: The goal of this investigation was to compare histollogically and histometrically the healing process of dehiscence-type defects treated by guided tissue regeneration (GTR) with resorbable polylactic acid membranes and nonresorbable ePTFE membranes. Six mongrel dogs were used. Buccal osseous dehiscences were surgically created on the distal roots of the mandibular third and fourth premolars. The defects were exposed to plaque accumulation for 3 months. After this period, the defects were randomly assigned to one ofthe treatments: GTR with resorbable membrane (GTR1), GTR with nonresorbable membrane (GTR2), open flap debridement (OFD) and non-treated control (NTC). After 3 months of healing, the dogs were sacrificed and the blocks were processed. The histometric parameters evaluated included: length of sulcular and junctional epithelium, connective tissue adaptation, new cementum, new bone (vertical component) and new bone area. A superior length of new cementum was observed in the sites treated by GTR, regardless of the type of barrier used (P<0.05), in comparison with OFD. No statistically significant differences were found between GTRl and GTR2 in all the parameters with the exception ofbone area. GTRl presented a greater bone area (P<0.05) when compared to GTR2, OFD and NTC. Within the limits of this study, it can be concluded that both batriers are equally effective for new cementum formation. The resorbable membrane (non-sutured) may provide a better osseous response than the nonresorbable membrane
Doutorado
Periodontia
Doutor em Clínica Odontológica

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Salis, Ana Maria Vilela de [UNESP]. "Avaliação da transmissibilidade de microrganismos periodontopatogênicos entre mães e filhos utilizando-se o teste Bana." Universidade Estadual Paulista (UNESP), 2000. http://hdl.handle.net/11449/95519.

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Descobertas recentes sugerem que microrganismos periodontopatogênicos são transmitidos entre membros de uma mesma família, pois há verificações da semelhança de linhagens de bactérias obtidas de seus integrantes, principalmente da mãe. Assim, o objetivo foi verificar se havia alguma correlação significativa entre os resultados do Teste BANA (Perioscan), obtidos em amostras de placa dentária subgengival de 54 crianças, entre 6 e 9 anos, e suas mães, todos residentes no município de Barretos-S.P. As amostras de placa subgengival foram colhidas com curetas periodontais de 432 sítios. Após a análise dos dados, os resultados do Teste BANA demonstraram que 67 sítios de crianças (31%) apresentaram reatividade positiva, enquanto que nas mães o número foi de 85 (39,3%). Em relação a negatividade do BANA nas crianças e suas mães, foi, respectivamente, de 149 (69%) e de 131 (60,7%) sítios, o que demonstrou a existência de uma relação estatisticamente significativa entre as variáveis BANA de mãe e filho. Os resultados do presente estudo permitiram sugerir que a presença de bactérias periodontopatogênicas nos filhos está relacionada à presença das mesmas bactérias nas mães, e que possível relacionamento de alterações periodontais nas mães podem representar significado importante no estabelecimento das patologias periodontais nos filhos.
Recent researchs suggest that periodontophatogens microrganisms are transmitted among the members of the same family, because it could be observed the likeness of the lineages of obtained from bacterias of family members, mainly of the mother. The purpose of this study was to verify if there was some significant correlation between the results of the Test BANA (Perioscan), obtained in samples of subgingival dental plaque of 54 children between 6 and 9 years and their mothers, resident in the municipal district Barretos-S.P. The samples of the subgingival plaques were picked up with periodontal instruments in 432 sites. After the statistical analysis of the data, the BANA Test results showed that in the children 67 (31%) of the sites presented positive reactivity while in the mothers 85 (39,3%) and in relation to the negativity of the BANA test, it was 149 (69%) e 131 (60,7%) respectivilly, this showed a statistically significant relationship between mother's and son BANA variable. The results of the present study let us to suggest that the presence of bacterial periodontophatogens in the children is related with the presence of the same bacterias in their mothers, and that a possible relationship of the periodontal alterations in the mothers can be an important factor in the establishement of periodontal pathologies in children.

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Leung, Wai Keung. "Effects of Treponema denticola on an oral epithelial cell model." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0009/NQ34575.pdf.

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Dockter, Kathryn M. Williams Karen B. "Relationship between pre-referral periodontal care and periodontal status at referral." Diss., UMK access, 2005.

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Thesis (M.S.)--School of Dentistry. University of Missouri--Kansas City, 2005.
"A thesis in dental hygiene education." Advisor: Karen B. Williams. Typescript. Vita. Title from "catalog record" of the print edition Description based on contents viewed March 12, 2007. Includes bibliographical references (leaves 57-65). Online version of the print edition.

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Susin, Cristiano. "Periodontal diseases in a representative urban population in south Brazil." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2004. http://hdl.handle.net/10183/6687.

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Background and Aims: There is little information about the epidemiology and risk factors of periodontal diseases in Latin America in general, and Brazil in particular. The principal aims of this study were to: 1) describe the prevalence and severity of periodontal attachment loss and gingival recession, and to assess the contribution of demographic, behavioral, and environmental exposures to the occurrence of periodontal disease outcomes in a sample representative of the urban population in the state of Rio Grande do Sul in south Brazil; and 2) report the epidemiology and risk indicators of aggressive periodontitis in this population. Methods: A representative sample consisting of 1,586 subjects 14-103 years of age (mean 38 y) and comprising 45.3% males and 54.7% females was selected using a multi-stage, probability, cluster sampling strategy. The subjects were interviewed using a structured questionnaire and underwent a full-mouth, six sites per tooth clinical examination in a mobile examination center. Results: Moderate and severe clinical attachment loss and gingival recession were widespread among adults in this population. The prevalence and extent of attachment loss ³5 and ³7 mm were 79% and 52% subjects, and 36% and 16% teeth; and for gingival recession ³3 mm and ³5 mm were 52% and 22% subjects, and 17% and 6% teeth, respectively. Aggressive periodontitis was diagnosed in 5.5% of subjects, which is significantly higher than the reported prevalence in most other populations. Among the main risk indicators for chronic as well as aggressive destructive periodontal diseases were: older age, low socioeconomic status, dental calculus, and smoking. Cigarette smoking accounted for an important part of periodontal disease burden, particularly in adults, and should be considered an important target in any prevention strategy aimed at reducing the burden of periodontal diseases. Partial recording methods consistently underestimated the prevalence of attachment loss in the population, and the extent of underestimation was dependent on the type of system used and the threshold of attachment loss. Conclusions: Destructive periodontal diseases are prevalent in this Brazilian population. Suitable disease prevention and health promotion programs should be established to improve the periodontal health in this population.

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Gonçalves, Daniela [UNESP]. "Efeito do tratamento periodontal não-cirúrgico em pacientes portadores de Diabetes mellitus tipo 2 com doença periodontal: análises clínica, enzimática e microbiológica." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/104745.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Objetivos: Avaliar o efeito do tratamento periodontal não-cirúrgico sobre parâmetros clínicos, microbiota subgengival e a atividade enzimática na saliva e no fluido sulcular gengival em pacientes portadores de diabetes e em indivíduos sistemicamente sadios, ambos com periodontite crônica. Material e método: a amostra populacional foi composta por 40 indivíduos divididos em dois grupos: 20 portadores de Diabetes mellitus tipo 2 com inadequado controle metabólico (grupo DM2) e 20 indivíduos sistemicamente sadios (grupo controle), ambos portadores de periodontite crônica. Clinicamente os indivíduos foram avaliados quanto: ao índice de placa visível (IPV), ao índice de sangramento marginal (ISM), à profundidade de sondagem (PS), ao nível clínico de inserção (NI), à presença de sangramento à sondagem (SS) e à presença de supuração (SUP). Foram realizadas coletas de saliva e de fluido sulcular gengival para determinação da atividade peroxidásica total salivar (PTS) e da mieloperoxidase (MPO), por meio de espectrofotometria. Amostras de placa bacteriana subgengival de 4 sítios rasos e 4 profundos com doença periodontal foram avaliadas pela técnica de Checkerboard DNA-DNA hybridization. Toda a amostra recebeu terapia periodontal não-cirúrgica com posterior fase de acompanhamento para realização de controle de placa profissional a cada quinze dias por um período de três meses. Todas as avaliações foram realizadas no baseline e aos três meses após o término da terapia periodontal. Resultados: No baseline, o grupo DM2 apresentou maior percentual de sítios com IPV e SS (p< 0.01) sem diferença estatisticamente significante entre grupos quanto aos demais parâmetros clínicos. O tratamento periodontal não-cirúrgico resultou em melhora significativa dos parâmetros clínicos avaliados nos 2 grupos. Aos três meses pós-tratamento foram observados maiores...
Objectives: To evaluate the effect of periodontal treatment on clinical parameters as well as on subgingival microbiota and enzimatic activity in the saliva and the gingival crevicular fluid of diabetes patients and systemically healthy individuals with chronic periodontitis. Material and Methods: The sample was constituted by 40 individuals divided in two groups: 20 type 2 diabetes mellitus patients with inadequate metabolic control (DM2 group) and 20 systemically healthy individuals (control group), both groups with chronic periodontitis. Clinical assessments included visible plaque index (VPI), bleeding on probing (BOP), gingival bleeding index (GBI), suppuration (SUP), probing depth (PD) and clinical attachment level (CAL). Saliva and gingival crevicular fluid samples were collected for determination of the total salivary peroxidase (TPS) activity and myeloperoxidase (MPO) activity respectively, by spectrophotometric assays. Subgingival plaque samples from 4 shallow and 4 deep sites with periodontal disease were evaluated by the Checkerboard DNA-DNA hybridization technique. All the patients received non-surgical periodontal therapy followed of the period for accomplishment of professional plaque control performed twice a month during three months. All the evaluations were assessed at baseline and 3 months after periodontal therapy. Results: At baseline, the DM2 group presented a significantly higher percentage of sites with VPI and BOP (p<0.01). No significant differences between groups were observed for the other clinical parameters. Nonsurgical periodontal treatment resulted in a significant improvement of clinical parameters. At 3 months post-treatment, the DM2 group presented significantly higher percentage of sites with VPI, GBI, BOP and mean PD (p<0.05). Regarding the microbiological analysis, at baseline, only C. rectus and S. anginosus were founded significantly higher... (Abstract complete click electronic access below)

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Ye, Ping. "Autoimmunity in chronic periodontitis." Thesis, The University of Sydney, 2003. http://hdl.handle.net/2123/4256.

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Profound perturbation of epithelial structure is a characteristic feature of the immunopatholoical response to bacterial antigens considered to be central in the pathogenesis of the destructive lesion of periodontitis. The pathological basis for the disturbance of epithelial structure is not understood. It was demonstrated that the structural integrity and functional differentiation of the lining epithelium is compromised in relation to inflammatory changes associated with destructive periodontitis. In the pathological lining epithelium of the periodontal pocket there was a marked reduction of epithelial cadherin important in intercellular adhesion, of involucrin, a marker of terminal differentiation, and of the gap junction connexions that form intercellular communication channels. These changes were associated with alterations of filamentous actin expression, collectively indicating profound perturbation of epithelial structure. The data reported support the concept that the ability of the pathological lining epithelium to function as an effective barrier against the ingress of microbial products into the tissues is severely compromised (Ye et al., 2000). In addition, a recent study (Ye et al., 2003) by Western analysis of serum IgG from all 22 patients with chronic periodontitis tested indicated recognition of multiple epithelial components in individual patterns. In contrast, subjects with a healthy periodontium displayed only trace recognition of epithelial antigens. Levels of epithelial-reactive antibodies were significantly correlated with attachment loss as an indication of disease activity. To investigate a possible relationship between the bacterial flora adjacent to the diseased sites and the presence of epithelial-reactive antibodies, subgingival plague samples were taken from deep periodontal pockets and cultured anaerobically. Gram positive bacteria containing antigens potentially cross-reactive with epithelial cells were reproducibly isolated by probing membrane colony lifts with affinity-isolated (epitheial-specific) antibodies. The bacteria were identified as streptococci (S. mitis, S. constellatus and two S. intermedius strains) and Actinomyces (A. georgiae, and A. sp. oral clone) by 16S rDNA sequence homology. Recognition by affinity-isolated antibodies of antigens from the captured organisms was confirmed by Western analysis. Conversely, absorption of affinity-isolated antibodies with bacterial species specifically reduced subsequent recognition of epithelial antigens. To identify the auto-antigens, a human keratinocyte cDNA expression library in Lambda phage was probed using a pooled sera. Groups of responders were detected for CD24 (a recently described adhesion molecule also known as P-selectin ligand), antioxidant protein 2 (a newly recognised member of the thiol-dependment anti-oxidant proteins), lavtate dehydrogenase A, the transcription factor NFAT5, and for three genes encoding novel proteins. Six identified bacteria, especially S intermedius were demonstrated to absorb antibodies reaching with identified auto-antigens in patterns varying between individuals. This evidence indicated that during the course of periodontits, subjects develop increased levels of antibodies to common oral bacteria amongst which are included tissue cross-reactive antigens. Periodontitis could therefore present a risk for the subsequent initiation or exacerbation of a broad spectrum of disease processes including autoimmune, inflammatory, proliferative and degenerative disorders.

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Ye, Ping. "Autoimmunity in chronic periodontitis." University of Sydney, 2003. http://hdl.handle.net/2123/4256.

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Doctor of Philosophy
Profound perturbation of epithelial structure is a characteristic feature of the immunopatholoical response to bacterial antigens considered to be central in the pathogenesis of the destructive lesion of periodontitis. The pathological basis for the disturbance of epithelial structure is not understood. It was demonstrated that the structural integrity and functional differentiation of the lining epithelium is compromised in relation to inflammatory changes associated with destructive periodontitis. In the pathological lining epithelium of the periodontal pocket there was a marked reduction of epithelial cadherin important in intercellular adhesion, of involucrin, a marker of terminal differentiation, and of the gap junction connexions that form intercellular communication channels. These changes were associated with alterations of filamentous actin expression, collectively indicating profound perturbation of epithelial structure. The data reported support the concept that the ability of the pathological lining epithelium to function as an effective barrier against the ingress of microbial products into the tissues is severely compromised (Ye et al., 2000). In addition, a recent study (Ye et al., 2003) by Western analysis of serum IgG from all 22 patients with chronic periodontitis tested indicated recognition of multiple epithelial components in individual patterns. In contrast, subjects with a healthy periodontium displayed only trace recognition of epithelial antigens. Levels of epithelial-reactive antibodies were significantly correlated with attachment loss as an indication of disease activity. To investigate a possible relationship between the bacterial flora adjacent to the diseased sites and the presence of epithelial-reactive antibodies, subgingival plague samples were taken from deep periodontal pockets and cultured anaerobically. Gram positive bacteria containing antigens potentially cross-reactive with epithelial cells were reproducibly isolated by probing membrane colony lifts with affinity-isolated (epitheial-specific) antibodies. The bacteria were identified as streptococci (S. mitis, S. constellatus and two S. intermedius strains) and Actinomyces (A. georgiae, and A. sp. oral clone) by 16S rDNA sequence homology. Recognition by affinity-isolated antibodies of antigens from the captured organisms was confirmed by Western analysis. Conversely, absorption of affinity-isolated antibodies with bacterial species specifically reduced subsequent recognition of epithelial antigens. To identify the auto-antigens, a human keratinocyte cDNA expression library in Lambda phage was probed using a pooled sera. Groups of responders were detected for CD24 (a recently described adhesion molecule also known as P-selectin ligand), antioxidant protein 2 (a newly recognised member of the thiol-dependment anti-oxidant proteins), lavtate dehydrogenase A, the transcription factor NFAT5, and for three genes encoding novel proteins. Six identified bacteria, especially S intermedius were demonstrated to absorb antibodies reaching with identified auto-antigens in patterns varying between individuals. This evidence indicated that during the course of periodontits, subjects develop increased levels of antibodies to common oral bacteria amongst which are included tissue cross-reactive antigens. Periodontitis could therefore present a risk for the subsequent initiation or exacerbation of a broad spectrum of disease processes including autoimmune, inflammatory, proliferative and degenerative disorders.

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Bogren, Anna. "Studies on the prevention of periodontal diseases /." Göteborg : Dept. of Periodontology, Institute of Odontology, The Sahlgrenska Academy, Göteborg University, 2007. http://hdl.handle.net/2077/7616.

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Hennig, Branwen Johanna Wanda. "Genetic polymorphisms and early-onset periodontal diseases." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311107.

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Cheng, David. "Understanding periodontal diseases and diabetes through resolvins." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12324.

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Thesis (M.A.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.
Introduction: Periodontal diseases are a group of diseases affecting the gingival, periodontal ligament, alveolar bone, or the cementum of the oral cavity. They are highly prevalent and have been associated with many different systemic diseases such as type 2 diabetes mellitus. Resolvins are a recently discovered set of pro-resolving molecules shown to influence inflammation in both periodontitis and type 2 diabetes mellitus. Published Studies: Periodontitis and type 2 diabetes mellitus are possibly linked through their inflammation inducing characteristics. Local inflammation produced by periodontal diseases influence systemic inflammation seen in type 2 diabetes mellitus and vice versa. Resolvins have been shown to positively influence periodontitis through superoxide inhibition, inducing bone regrowth, reducing systemic inflammation, osteoclast modulation, and increasing neutrophil phagocytosis. Resolvins have also been shown to improve insulin sensitivity in obese and diabetic mice. Conclusion: Because periodontitis and type 2 diabetes mellitus have been linked through their inflammatory nature, the influence of resolvins on both diseases can possibly elucidate connections between the two diseases. The identification of shared receptors between resolvins and other inflammatory molecules could possibly provide clues to the mechanisms which our bodies control inflammation in these diseased states. The potential for resolvins in treatment of periodontal diseases and type 2 diabetes mellitus is promising, and further research is needed to identify all effects that resolvins have on the body.

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Schmalz, Gerhard, Simin Li, Ralph Burkhardt, Sven Rinke, Felix Krause, Rainer Haak, and Dirk Ziebolz. "MicroRNAs as salivary markers for periodontal diseases." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-206460.

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The aim of this review is to discuss current findings regarding the roles of miRNAs in periodontal diseases and the potential use of saliva as a diagnostic medium for corresponding miRNA investigations. For periodontal disease, investigations have been restricted to tissue samples and five miRNAs, that is, miR-142-3p, miR-146a, miR-155, miR-203, and miR-223, were repeatedly validated in vivo and in vitro by different validation methods. Particularly noticeable are the small sample sizes, different internal controls, and different case definitions of periodontitis in in vivo studies. Beside of that, the validated miRNAs are associated with inflammation and therefore with various diseases. Furthermore, several studies successfully explored the use of salivary miRNA species for the diagnosis of oral cancer. Different cancer types were investigated and heterogeneous methodology was used; moreover, no overlap of resultswas found. In conclusion, fivemiRNAs have consistently been reported for periodontitis; however, their disease specificity, detectability, and expression in saliva and their importance as noninvasive markers are questionable. In principle, a salivary miRNA diagnostic method seems feasible.However, standardized criteria and protocols for preanalytics, measurements, and analysis should be established to obtain comparable results across different studies.

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Natto, Suzan Bakur. "Tobacco smoking and periodontal health in a Saudi Arabian population /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-438-4/.

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Almeida, Juliano Milanezi de. "Ação da terapia fotodinâmica no tratamento da doença periodontal induzida : estudo histológico em ratos /." Araçatuba, 2004. http://hdl.handle.net/11449/96161.

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Orientador: Valdir Gouveia Garcia
Resumo: O presente estudo teve por objetivo avaliar histologicamente o efeito da terapia fotodinâmica (PDT) na progressão da doença periodontal induzida em ratos. Realizou-se a adaptação de uma ligadura de algodão na margem gengival do primeiro molar inferior esquerdo de cento e vinte ratos. Os animais foram divididos aleatoriamente em quatro grupos experimentais(n=30): Grupo I: nenhum tipo de tratamento realizado, somente a presença da ligadura; Grupo II (MB): tratamento com aplicação tópica de azul de metileno (100 æg/mL) dois dias após adaptação da ligadura; Grupo III (LLT): tratamento com Laser em baixa intensidade dois dias após adaptação da ligadura; e Grupo IV (PDT): tratamento com aplicação tópica de azul de metileno (100 æg/mL) seguido da aplicação do Laser em baixa intensidade dois dias após adaptação da ligadura. A superfície mesial dos dentes no Grupo III e IV foram irradiados com o Laser de diodo de GaAlAs, com 685 nm (50 mW, 120 s, 4.5 J/cm2). Todos os grupos foram subdivididos em subgrupos (n=10) e sacrificados nos períodos de 5, 15 e 30 dias pós-operatório. As peças foram processadas para análise histológica e coradas pela técnica de H&E. Através de um sistema de escores, vários parâmetros foram utilizados para avaliar o tecido conjuntivo, ligamento periodontal, superfície radicular e tecido ósseo. A análise estatística foi realizada pelo teste de Kruskal-Wallis, (p<0.05). Os resultados indicaram diferença no nível da inserção do ligamento periodontal entre o Grupo I (C) e Grupo III (LLT) (p=0,0327), Grupo II (MB) e Grupo III (LLT) (p=0,0118) e entre o Grupo III (LLT) e Grupo IV (PDT) (p=0,0076) no período de 15 dias de pó-operatório. Não ocorreu diferença estatisticamente significante ...(Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The purpose of this study was to histologically evaluate the effect of photodynamic therapy (PDT) on the progression of experimentally induced periodontal disease in rats. Cotton ligatures were placed at the gingival margin level of the lower left first molar in one hundred and twenty rats. The animals were then randomly divided evenly into 4 groups (n=30): Group I (C): no treatment; Group II (MB): treated with topical application of methylene blue (100æg/ml) 2 days after ligature placement; Group III (LLT): treated by low level laser therapy 2 days after ligature placement; and Group IV (PDT): treated with topical application of methylene blue (100æg/ml) followed by low level laser therapy 2 days after ligature placement. The mesial aspect of the teeth in Groups III and IV were irradiated using a 685nm GaAlAs laser (50mW, 120s, 4.5J/cm2). All groups were subdivided into subgroups (n=10) and euthanized at either 5, 15 or 30 days post-operative. Block sections were routinely processed for histological analysis using H&E stain. Using a scoring system, several biological parameters were used to evaluate the connective tissue, periodontal ligament, root surface and bone. The data were statistically analyzed (Kruskal-Wallis, p<0.05). The results showed significant differences in the periodontal attachment level between Group I (C) and Group III (LLT) (p=0,0327), Group II (MB) and Group III (LLT) (p=0,0118) and between Group III (LLT) and IV (PDT) (p=0.0076) at 15 days postoperative.There were no significant differences in any of the evaluated parameters...(Complete abstract click eletronic address below)
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Prado, Rosana Leal do [UNESP]. "Avaliação da sensibilidade à insulina e transdução do sinal insulínico em ratos adultos, proles de ratas com doença periodontal." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/95422.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Nos dias atuais, a crescente incidência de diabetes mellitus no mundo torna fundamental a idéia de se identificar fatores de risco que levam ao desenvolvimento da doença e proporcionar sua prevenção. Diversos estudos têm levado a considerar as condições bucais não mais de maneira isolada, mas em suas relações com o corpo humano. Este posicionamento também é válido para as periodontopatias, que têm sido apontadas por diversos estudos como fator de risco para o desenvolvimento de doenças, entre elas o parto prematuro de bebês com baixo peso e o diabetes mellitus. O nascimento prematuro sobressai‐se como o maior problema peri‐natal em muitos países, contribuindo substancialmente para a mortalidade infantil e para o desenvolvimento de uma infância repleta de problemas. Há ainda estudos que apontam que adultos que nasceram com baixo peso tem um maior risco de desenvolver diabetes mellitus na vida adulta. A revisão destes estudos demonstra a inter‐relação entre estas doenças e alguns dos mecanismos biológicos envolvidos, buscando alertar quanto ao estilo de vida propício ao desenvolvimento de periodontopatias e a busca por hábitos preventivos, além da necessidade de mais estudos para elucidar os mecanismos envolvidos nesta inter‐relação.
Currently, the increasing incidence of diabetes mellitus in the world makes the idea of identifying risk factors which can lead to the development of the disease and ways to prevent it as an important matter. Several studies have considered oral conditions in an integrated approach with the general health conditions. This approach is also valid for periodontal diseases, which have been pointed as a risk factor for the development of some diseases, like preterm birth, low weight babies and diabetes mellitus. Premature birth has been pointed out as the major prenatal problem in several countries, contributing substantially with infant mortality and the development of other infant problems. There are also studies showing that adults with a preterm birth history have a higher risk of developing diabetes mellitus. The review of these researches demonstrate the inter‐relation between these diseases and some of the involved biological mechanisms, aiming to alert population about life style conditions which can lead to periodontal diseases and also to promote preventive measures, as well as the need of more studies to elucidate the involved mechanisms of this inter‐relation.

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17

Wagner, Michael. "Periotestwerte und Okklusion im gesunden Gebiss." Tübingen : Aus der Abteilung Poliklinik für Zahnärztliche Chirurgie und Parodontologie des Zentrums für Zahn-, Mund- und Kieferheilkunde der Universität Tübingen, 1988. http://catalog.hathitrust.org/api/volumes/oclc/39329690.html.

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18

Spirandeli, Daniela [UNESP]. "Associação entre estado nutricional e doença periodontal crônica." Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/96215.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
O objetivo deste estudo foi avaliar a associação do estado nutricional à periodontite. Para isso, foram selecionadas 32 mulheres adultas com idade entre 30 e 50 anos. A amostra foi dividida em dois grupos a partir da média de perda de inserção periodontal: grupo controle (n=17) com média < 2 mm e grupo teste (n=15) com média = 2 mm. Todas as voluntárias foram submetidas a questionário de saúde geral e de freqüência alimentar. O estado sócio-econômico foi obtido pelo nível de escolaridade e pela aplicação de questionário de classificação sócio-econômica. A avaliação periodontal foi realizada a partir da determinação do Índice de Placa Visível (IPV), do Índice de Sangramento Marginal (ISM) e do nível de inserção. Foi calculado o índice de massa corporal (IMC) e foram solicitados os seguintes exames laboratoriais: hemograma, HDL-colesterol, triglicerídeos, vitamina B12, zinco sérico e ácido fólico. Os resultados revelaram que não houve diferença estatística quanto ao estado sócio-econômico entre os grupos, bem como na análise do IMC, embora tenha se observado uma alta freqüência de sobrepeso e de obesidade nos dois grupos. Comparando-se os valores médios, observou-se diferença estatisticamente significante entre os grupos controle e teste (p < 0,01) quanto à perda de inserção periodontal, ao nível de profundidade de sondagem e ao ISM. Observou-se uma maior freqüência de voluntárias que consumiam frutas, legumes e verduras pelo menos uma vez por semana nos dois grupos. O eritrograma mostrou-se alterado somente nas voluntárias do grupo teste, enquanto no grupo controle os resultados foram normais. As alterações observadas foram: número baixo de eritrócitos, hematócrito reduzido e concentração reduzida de hemoglobina, volume corpuscular médio (VCM) reduzido e índice de hemoglobina corpuscular médio (HCM) reduzido...
The study`s aim was to evaluate the association between nutritional status and periodontitis. For this, 32 adult women had been selected, no-smokers within the age of 30 and 50 years. The sample was divided into two groups according to mean of attachment loss: control group (n=17) with mean < 2 mm and test group (n=15) with mean = 2 mm. All the volunteers were submitted to a questionnaire of general health and of dietary frequency. The socio-economic status was determined to educational level and to questionnaire of socio-economic classification. The periodontal exam included Visible Plaque Index, Gingival Index and attachment level. The Body Mass Index (BMI) has been calculated and erythrocyte count and leukocyte count measurements were performed and levels of HDL-cholesterol, triglycerides, vitamin B12, zinc and folate. The results revealed that didn`t statistics difference to socio-economic status and to BMI between the groups, although observed the high frequency of the overweight and obesity in the two groups. Comparing the mean values, there was different statistically significant between the groups control and test (p < 0,01) to attachment loss, probing depth and gingival index. There was increased frequency of the volunteers that dietary intake fruits and vegetables at least a time per week in two groups. The erythrocyte count presented altered only in the volunteers of the test group while in the control group the results were normal. The alterations were: lower numbers of erythrocytes, lower hematocrit, lower hemoglobin concentration, lower mean corpuscular volume (MVC) and lower mean corpuscular hemoglobin index (MHC). The leukocyte count showed increased frequency of the alterations in the two groups and the relative and/or absolute eosinophilia was more evident in the test group. Lower folate level was observed too in the test group... (Complete abstract, click electronic address below)

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19

Spirandeli, Daniela. "Associação entre estado nutricional e doença periodontal crônica /." Araraquara: [s.n.], 2006. http://hdl.handle.net/11449/96215.

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Resumo: O objetivo deste estudo foi avaliar a associação do estado nutricional à periodontite. Para isso, foram selecionadas 32 mulheres adultas com idade entre 30 e 50 anos. A amostra foi dividida em dois grupos a partir da média de perda de inserção periodontal: grupo controle (n=17) com média < 2 mm e grupo teste (n=15) com média = 2 mm. Todas as voluntárias foram submetidas a questionário de saúde geral e de freqüência alimentar. O estado sócio-econômico foi obtido pelo nível de escolaridade e pela aplicação de questionário de classificação sócio-econômica. A avaliação periodontal foi realizada a partir da determinação do Índice de Placa Visível (IPV), do Índice de Sangramento Marginal (ISM) e do nível de inserção. Foi calculado o índice de massa corporal (IMC) e foram solicitados os seguintes exames laboratoriais: hemograma, HDL-colesterol, triglicerídeos, vitamina B12, zinco sérico e ácido fólico. Os resultados revelaram que não houve diferença estatística quanto ao estado sócio-econômico entre os grupos, bem como na análise do IMC, embora tenha se observado uma alta freqüência de sobrepeso e de obesidade nos dois grupos. Comparando-se os valores médios, observou-se diferença estatisticamente significante entre os grupos controle e teste (p < 0,01) quanto à perda de inserção periodontal, ao nível de profundidade de sondagem e ao ISM. Observou-se uma maior freqüência de voluntárias que consumiam frutas, legumes e verduras pelo menos uma vez por semana nos dois grupos. O eritrograma mostrou-se alterado somente nas voluntárias do grupo teste, enquanto no grupo controle os resultados foram normais. As alterações observadas foram: número baixo de eritrócitos, hematócrito reduzido e concentração reduzida de hemoglobina, volume corpuscular médio (VCM) reduzido e índice de hemoglobina corpuscular médio (HCM) reduzido... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The study's aim was to evaluate the association between nutritional status and periodontitis. For this, 32 adult women had been selected, no-smokers within the age of 30 and 50 years. The sample was divided into two groups according to mean of attachment loss: control group (n=17) with mean < 2 mm and test group (n=15) with mean = 2 mm. All the volunteers were submitted to a questionnaire of general health and of dietary frequency. The socio-economic status was determined to educational level and to questionnaire of socio-economic classification. The periodontal exam included Visible Plaque Index, Gingival Index and attachment level. The Body Mass Index (BMI) has been calculated and erythrocyte count and leukocyte count measurements were performed and levels of HDL-cholesterol, triglycerides, vitamin B12, zinc and folate. The results revealed that didn't statistics difference to socio-economic status and to BMI between the groups, although observed the high frequency of the overweight and obesity in the two groups. Comparing the mean values, there was different statistically significant between the groups control and test (p < 0,01) to attachment loss, probing depth and gingival index. There was increased frequency of the volunteers that dietary intake fruits and vegetables at least a time per week in two groups. The erythrocyte count presented altered only in the volunteers of the test group while in the control group the results were normal. The alterations were: lower numbers of erythrocytes, lower hematocrit, lower hemoglobin concentration, lower mean corpuscular volume (MVC) and lower mean corpuscular hemoglobin index (MHC). The leukocyte count showed increased frequency of the alterations in the two groups and the relative and/or absolute eosinophilia was more evident in the test group. Lower folate level was observed too in the test group... (Complete abstract, click electronic address below)
Orientador: Miriam Aparecida Onofre
Coorientador: Elaine Maria Sgavioli Massucato
Banca: Silvana Regina Perez Orrico
Banca: Luiz Eduardo Montenegro Chinellato
Mestre

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20

Nadeem, Muhammad. "The association between periodontitis and end-stage renal disease." Thesis, University of the Western Cape, 2006. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_6748_1194349692.

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Patients who are in end-stage renal disease (ESRD) experience a significantly increased rate of atherosclerotic complications. Inflammation plays a central role in the pathogenesis of these complications. The major acute phase protein, C-reactive protein (CRP) has been found to predict all-cause and cardiovascular mortality in ESRD patients. Many patients in ESRD experience elevated CRP levels without an overt infection. Periodontal diseases in the general population have been associated with both an increased prevalence of atherosclerotic complications and an elevation in serum CRP values. The aim of this present study was to investigate whether periodontal disease is associated with increased systemic inflammation reflected by CRP values, in patients with ESRD on maintenance haemodialysis (HD) or perioneal dialysis (PD).

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21

Guimarães, Gustav. "Influência da extensão da doença periodontal no perfil sanguíneo de ratos Wistar /." Araçatuba, 2016. http://hdl.handle.net/11449/144733.

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Orientador: Luciano Tavares Angelo Cintra
BancaEloi Dezan Junior
Renata Oliveira Samuel
Christine Men Martins
Resumo: O obje tivo deste trabalho foi invest igar a influ ê ncia da extensão da doença periodontal no perfil sanguíneo de ratos Wistar. Foram utilizados 30 ratos divididos em 3 grupos de 10 animais: C - ratos controle ; DP1 - ratos com doença periodontal em 3 molares superiores ; DP2 - ratos com doença per iodontal em 3 molares superiores e 3 inferiores . A doença periodontal foi induzida por meio da confecção de ligadura em torno do colo dentário dos molares selecionados de acordo com cada grupo . Após 30 dias, os animais foram anestesiados e, por meio de uma punção cardíaca, foi coletado 5 ml de sangue para as análises dos parâmetros do hemograma, creatinina, triglicérides e colesterol. Em seguida, os animais foram sacrificados e as maxilas removidas e processadas para análise histopatológica em coloraçã o de H .E . para caracterizar o perfil da doença periodontal em cada animal . Os resultados obtidos a partir do tecido hematológico foram analisados estaticamente por meio dos testes de ANOVA e Tukey, com nível de significância de 5%. Pode - se observar nos grupos DP 1 e DP2 presença de infiltrado inflamatório crônico, perda de inserção conjuntiva, perda de estrutura óssea cortical e alveolar, presença de reabsorções dentárias, presença de b iofilme e sequestro ósseo. Quant o ao perfil sanguíneo, pode - se observar diferen ça estatisticamente significante entre o grupo controle e os grupos DP1 e DP2 em relação à quantidade de leucócitos e linfócitos (p<0,05). Ainda, o grupo DP2 apresentou maior quantidade de leucócito s e neutrófilos em relação ao grupo DP1 e controle (p<0,05 ). Pode - se concluir que a presença da doença periodontal eleva a quantidade de l eucócitos, neutrófilo e linfócitos no sangue de ratos Wistar, e que, a extensão da doença periodontal influencia na quanti dade de leucócitos e neutrófilos.
Abstract: The aim of this study was to evaluate the influence of the periodontal disease extension o n the blood profile of Wistar rats. Thirty rats were divided into 3 groups of 10 animals each : C control rats; DP1 - rats with periodontal disease in 3 upper molars; DP2 - rats with periodontal disease in 3 upper and 3 lower molars. Periodontal disea se was induced by ligature around the tooth according to each group. After 30 days, the animals were killed and 5ml of blood was collected for analyzes of blood cou nt parameters, creatinine, triglycerides and cholesterol. Then the animals were sacrificed and the jaws removed and processed for histopathological analysis to characterize, in H.E. staining, the profile of periodontal disease in each animal. The results f rom the hematologic tissue were analyzed statistically by ANOVA and Tukey test, with 5% significance level. It can be observed in groups DP1 and DP2 presence of chronic inflammatory infiltrates, connective tissue attachment loss and alveolar bone cortical structure loss, presence of resorptions, presence of biofilm and bone sequestration. As for the blood profile, it is can observe a statistically significant difference between the control group and the groups DP1 and DP2 to the amount of leukocytes and lym phocytes (p <0.05). Further, DP2 group had a higher amount of leukocytes and neutrophils compared to DP1 and control group (p <0.05). It can be concluded that the presence of periodontal disease increases the amount of leukocytes, neutrophils, and lymphocy tes in the blood of Wistar rats, and the extent of periodontal disease affects the quantification of leukocytes and neutrophils.
Doutor

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22

Barilli, Ana Lucia de Azevedo. ""Prevalência das doenças periodontais em pacientes com doença isquêmica coronariana aterosclerótica, em Hospital Universitário"." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/17/17139/tde-15092003-082710/.

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As doenças periodontais (DP) são precedidas em importância apenas pela cárie dentária como problema de saúde bucal coletiva no Brasil. Ambas são doenças infecciosas ainda muito prevalentes, entretanto é dada às DP uma importância questionavelmente secundária, pois não são sistematicamente investigadas e prevenidas em saúde pública. Pelo fato de sua prevalência ser atualmente desconhecida no Brasil, a alta freqüência das formas leves e moderadas das doenças periodontais na população como um todo e de suas formas mais graves em grupos ou indivíduos de risco, dentre estes os portadores de cardiopatias isquêmicas, motivou este estudo no Ambulatório de Cardiopatia Isquêmica do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, cotejando os resultados com outros obtidos em grupo de pessoas não-cardiopatas atendidas na mesma instituição. Foi investigada a prevalência e gravidade das doenças periodontais, bem como a prevalência de seus fatores de risco, história médica da presença de doenças de interesse à periodontia (diabetes, hipertensão, acidente vascular cerebral) e comportamento relativo à higiene bucal. Dentre as 634 pessoas examinadas na fase de recrutamento dos participantes, 480 foram do grupo de pacientes cardiopatas isquêmicos e 154 de grupo de não-cardiopatas. Foram selecionados respectivamente de cada grupo, 58 e 62 participantes, na faixa etária de 30 a 79 anos, para a investigação periodontal. A média da idade foi de 53 anos em ambos os sexos para os pacientes cardiopatas e de 40 anos nos homens e 37 anos nas mulheres nos pacientes não-cardiopatas. Foram utilizados o Índice Periodontal Comunitário (IPC) e o índice de Perda de Inserção periodontal (PI), ambos recomendados pela OMS (1999). Os resultados mostraram um predomínio de sextantes nos escores indicativos das formas graves da DP entre os pacientes cardiopatas (74,1% contra 20,2%; p < 0,00001). Dentre os pacientes cardiopatas apenas 1,1% dos sextantes exibiram saúde periodontal, contra 32,0% nos pacientes não-cardiopatas (p < 0,00001). No tocante a história pregressa da DP, mensuradas através da perda de inserção, 6,0% dos sextantes não a exibiram entre os pacientes cardiopatas, contra 68,0% dos não-cardiopatas (p < 0,00001). Eram portadores de fatores de retenção de biofilme dental 100,0% dos pacientes cardiopatas e 82,3% dos pacientes não-cardiopatas (p < 0,001). Exigiam tratamento periodontal mais complexo, normalmente praticados por especialistas em periodontia, 94,8% dos pacientes cardiopatas contra 33,9% dos pacientes não-cardiopatas (p < 0,0001). Necessitavam de tratamento de bolsas > 6mm 79,3% dos pacientes cardiopatas contra 9,7% dos pacientes não-cardiopatas (p < 0,0001). Alguns fatores de risco comprovado e/ou provável às DP, foram investigados nos pacientes cardiopatas e pacientes não-cardiopatas: observou-se tabagismo em 10,4% e 33,9% (p < 0,01), respectivamente; alcoolismo em 44,8% e 24,2% (p < 0,02), respectivamente; diabetes em 29,3% e 1,6% (p < 0,0001), respectivamente; hipertensão arterial em 34,5% e 8,1% (p < 0,001), respectivamente. Conclusões: As DP mostraram-se muito prevalentes nos dois grupos estudados, sendo de maior gravidade nos pacientes com cardiopatia isquêmica. A elevada prevalência de fatores de risco às DP aponta para a necessidade de adoção de estratégias de intervenção para minimizá-los.
Periodontal diseases are preceded in importance only by dental caries as oral public health problem in Brazil. Both are infectious diseases and with high prevalences, however, a secondary importance is given to periodontal diseases because they are not routinely investigated and prevented at public health level. Presently its prevalence is not known in the Brazilian population. The high prevalence of mild and moderate forms of periodontal diseases in the general population, and its severe forms in specific groups or in high risk patients, as those with ischaemic coronary diseases, motivated this survey. It was carried out among patients from the Outpatient Clinic of Ischaemic Coronary Disease Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo and using for comparisons patients from other clinics of the same hospital. The prevalence and severity of periodontal diseases were investigated, as well as the prevalence of their risk factors, medical history of diseases with periodontic interest (diabetes, hypertension, stroke), and behaviour related to oral hygiene. During the recruitment phase, among 634 patients examined, 480 were from the group with cardiopathy and 154 from the group without cardiopathy. From each group were selected, respectively, 58 and 62 participants, aged 30 to 79 years for the periodontal investigation. Mean age was 53 years for both sexes in the group with cardiopathy and 40 years for men and 37 years for women in the group without cardiopathy. The Community Periodontal Index and the Attachment Periodontal Index, both recommended by the World Health Organization (1999), were used. Results showed a predominance of sextants in the scores indicating severe forms of periodontal diseases among patients with cardiopathy (74.1 vs. 20.2%; p< 0.00001). Among patients with cardiopathy, only 1.1% of the sextants showed periodontal health against 32.0% in the other group (p< 0.00001). Previous history of periodontal diseases, measured through lost of insertion, was present in 6.0% of the sextants in patients with cardiopathy and 68.0% in those without cardiopathy (p< 0.0001). All patients with cardiopathy and 82.3% of those without cardiopathy were carriers of retention factors of dental biofilm (p< 0.001). It was found that 94.8% of the patients with cardiopathy against 33.9% of the other group (p< 0.0001) required more complex periodontal treatment, usually performed by periodontal specialists. Treatment of sites ≥ 6mmm was required by 79.3% of the patients with cardiopathy and by 9.7% from the other group (p< 0.0001). The frequency of confirmed or possible risk factors for periodontal diseases in the groups with and without cardiopathy were, respectively: smoking 10.4 and 33.9% (p< 0.001); alcoholism 44.8 and 24.2% (p< 0.02); diabetes 29.3 and 1.6% (p< 0.0001); hypertension 34.5 and 8.1% (p< 0.001). Conclusions: Periodontal diseases were highly prevalent in the two groups studied, but with higher severity among patients with cardiopathy. The high frequency of risk factors for periodontal diseases in both groups appointed to the need of intervention strategies towards these risk factors.

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23

Packer, Samantha. "Bacterial-epithelial cell interactions in the periodontal diseases." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1445766/.

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Periodontal diseases result from a complex interaction between a biofilm containing commensal and periopathogenic bacteria and the host innate and acquired defense systems. The interaction of oral commensal and pathogenic bacteria and their effect on ' cell behaviour, particularly the synthesis of antibacterial and inflammatory molecules, has been the focus of this project. The messenger RNA (mRNA) and protein expression of human beta-defensin and pro-inflammatory cytokine mRNA in the gingiva of patients suffering from the periodontal diseases was also determined. Patients suffering periodontal diseases showed increased mRNA expression of human beta-defensins and cytokines compared to controls, however, there was no difference in human beta-defensin protein expression between diseased and control tissue samples. Further studies were then carried out to determine the effect of oral commensal and periopathogenic bacteria and their surface components on oral epithelial cells (OECs). An oral squamous carcinoma cell line was found to produce IL-8 protein and express mRNA for human beta-defensin 2 (hpD-2), both of which were induced by several oral bacterial cell surface components, including LPS. The stimulatory effect of LPS was subsequently found to involve the LPS receptor, CD 14. The presence of toll-like receptor mRNA was also demonstrated and results showed that their expression may be regulated by bacteria associated molecular patterns. Both live- and heat-killed oral bacterial pathogens, A. actinomycetemcomitans and P. gingivalis induced production of IL-8 protein and hpD-2 mRNA from OECs. Exposure to the oral commensals S. sanguis and S. gordonii resulted in a decrease in the production of IL-8 mRNA from OECs, whilst heat-killed S. sanguis upregulated hpD-2 mRNA. A highly invasive strain of A. actinomycetemcomitans was shown to adhere to OECs to a greater degree, and also led to a greater induction of hpD-2 mRNA and IL-8 protein compared to a non-invasive strain. Further, isogenic mutants of the oral commensal S. gordonii DL1 Challis, deficient in the production of antigen I/II-family proteins SspA and SspB and the fibrillar cell surface proteins CshA and CshB, showed reduced adhesion to OECs. All strains had comparable effects on IL-8 protein and hpD-2 mRNA expression in OECs. The results presented in this thesis demonstrate the expression profile of human beta- defensins and cytokines in healthy and diseased gingival tissue. hpD-2 has been shown to be upregulated in oral epithelial cells by a range of oral commensal and pathogenic bacteria and their products. It has also been shown that the invasive nature of oral bacteria may contribute to increased expression of hpD-2 messenger RNA in oral epithelial cells. The upregulation of hpD-2 mRNA by a wide variety of components, bacterial or otherwise in oral epithelial cells may have therapeutic potential, however further studies would need to be carried out to determine the correlation between mRNA and protein expression of hpD-2.

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Mulli, Tonnie. "Proteomic investigation of salivary biomarkers in periodontal diseases." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/proteomic-investigation-of-salivary-biomarkers-in-periodontal-diseases(a5673229-5c6a-4f36-b47d-fa40b24e453a).html.

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Introduction: The aim of the study was to investigate novel biomarkers of periodontal disease present in GCF and saliva. Methods: The identities of specific putative biomarkers identified by SELDI-TOF MS were confirmed using 1-D PAGE coupled with LC-MS/MS. These biomarkers were then tested using ELISA in the samples that had been initially screened using SELDI-TOF MS as well as in saliva samples in an independent cohort selected according to diabetic status rather than periodontal status. The effect of non-surgical periodontal therapy, diabetes, saliva sample collection method, eating, time of day, day of the week and storage conditions on the salivary concentration of human neutrophil peptide 1-3 (HNP 1-3), cathelicidin LL-37 and protein S100A8 were tested. Copy number variation for HNP 1-3 gene, DEFA1A3 was tested in an independent cohort and the data analysed for association with presence and degree of periodontal disease. Results: Antimicrobial peptides, HNP 1-3, LL-37 and S100A8 were identified. GCF and salivary HNP 1-3 and LL-37 concentrations were significantly elevated in periodontitis than in gingivitis or health. LL-37 was significantly elevated in aggressive periodontitis (AgP) compared with chronic periodontitis (CP) and gingivitis/health. Periodontal therapy reduced the salivary levels of HNP 1-3. Diabetes, eating and day of week had no significant effect on AMP levels. Saliva collection using spitting method yielded significantly more AMPs than using Salivettes®. Sample collection at 16:00 hours yielded significantly higher amounts of AMPs than samples collected at other times. Sample storage at room temperature (RT) for up to 48 hours had no significant impact on the salivary HNP 1-3 and LL-37 concentration while a proteinase inhibitor did not did improve the recovery of the AMPs after 72 hours.<= 6 copies of DEFA1A3 copy numbers were partly associated with periodontal disease.

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Ren, Lei, and Ph D. 任蕾. "Lipopolysaccharide-binding protein and CD14 in human gingiva." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B31374281.

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Silva, Filho Wagner Leal Serra e. "Avaliação microbiologica da interrelação entre a doença periodontal e a doença aterosclerotica coronariana obstrutiva." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290391.

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Orientador: Antonio Wilson Sallum
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
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Resumo: O objetivo deste estudo foi avaliar a interrelação entre a Doença Periodontal e a Doença Aterosclerótica Coronariana Obstrutiva (DACO), em pacientes com indicação de Angioplastia Transluminal Coronária Percutânea (ATCP). Para esse fim, foram selecionados 18 pacientes com DACO e diagnóstico de doença periodontal crônica. Após exame periodontal, foram coletadas amostras de biofilme subgengival nos sítios periodontalmente comprometidos, bem como nos balões utilizados durante o procedimento de Angioplastia para esmagamento da placa aterosclerótica. Em seguida, as amostras foram utilizadas para verificação dos microorganismos presentes, por meio da técnica de amplificação do DNA pela reação em cadeia de polimerase (PCR). As amostras de biofilme subgengival e dos balões foram comparadas entre si e com DNA puro dos patógenos periodontais (Aggregatibacter actinomycetencomitans - Aa, Porphyromonas ginginvalis - Pg, Prevotella intermédia - Pi, Tannerella forsythensis - Tf). Ao final das análises microbiológicas, os resultados detectaram Pg em 11,1% e Tf em 38,9% dos balões de angioplastia. Nenhuma amostra de balão foi positiva para Prevotella intermédia (Pi) e para Aggregatibacter actinomycetemcomitans (Aa). Após análise estatística pelo teste McNemar, com nível de significância de 5%, e dentro dos limites deste estudo, pode-se concluir que apesar de terem sido encontradas amostras de dois patógenos periodontais (Porphyromonas gingivalis e Tannerella forsythensis) nos balões de angioplastia e no biofilme subgengival, esta correlação não foi estatisticamente significante; não permitindo a afirmação de que exista associação causal entre a doença periodontal e a doença aterosclerótica coronariana obstrutiva.
Abstract: The aim of this study was to evaluate the relationship between periodontal disease and obstructive atherosclerotic coronary disease (OACD) in patients with indication for percutaneous transluminal coronary angioplasty (PTCA). Eighteen patients with diagnose of periodontal disease and OACD were selected for this study. After thorough periodontal examination subgengival biofilm samples were collected in periodontal pockets with probing depth _ 5mm. The balloons used to crush the atherosclerotic plaques during the angioplasty procedure were collected. Bacteria found in biofilm and balloons were identified using polymerase chain reaction (PCR) assays. Bacteria from periodontal pockets were compared with the microorganisms detected in the atherosclerotic plaques obtained from the same patient and with the pure DNA of periodontal pathogens (Aggregatibacter actinomycetencomitans - Aa, Porphyromonas ginginvalis - Pg, Prevotella intermédia - Pi, Tannerella forsythensis - Tf). After the microbiological analysis it was observed the presence of Pg in 11.1% of the samples, Tf in 38.9% of the balloons. None of the balloons were positive for the presence of Pi and Aa. After statistic analysis for McNemar test, with significance level of 5%, and within the limits of this study, it can be concluded that even though two periodontal pathogens (Porphyromonas gingivalis e Tannerella forsythensis) were found both in the balloons and subgingival biofilms, the correlation between the samples was not significant, thus not allowing the assertive that there is a causal relationship between periodontal disease and obstructive atherosclerotic coronary disease.
Doutorado
Periodontia
Doutor em Clínica Odontológica

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Taiete, Tiago 1987. "Molecular technologies in the study of periodontal diseases = Tecnologias moleculares no estudo das doenças periodontais." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/287903.

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Orientador: Márcio Zaffalon Casati
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
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Resumo: A periodontite agressiva é caraterizada por apresentar início precoce, rápida progressão e pobre resposta as abordagens terapêuticas quando comparado a periodontite crônica. Entretanto, os mecanismos responsáveis por essas diferenças ainda não são completamente compreendidos. Ferramentas como a genômica, proteômica ou transcriptômica podem esclarecer esses aspectos, gerando importantes informações a respeito da patogênese das doenças periodontais. Portanto, os objetivos do presente estudo foram: i) Apresentar uma revisão de literatura focada na aplicação da genômica, transcriptômica, proteômica e metabolômica no estudo das doenças periodontais. ii) Avaliar as diferenças no perfil de expressão gênica da mucosa mastigatória, sem a influência do biofilme subgengival, em indivíduos com histórico de periodontite agressiva e crônica, comparando-os entre si e também com o perfil de expressão de indivíduos sem histórico de periodontite visando à identificação de possíveis alterações constitutivas na expressão de genes que podem estar relacionadas com as diferenças entre as duas formas de periodontite. Para o primeiro objetivo, foi realizada uma revisão dos artigos que empregaram as tecnologias ômicas no estudo das doenças periodontais. Os estudos presentes na literatura indicaram que essas tecnologias podem levar a um melhor entendimento dos eventos moleculares envolvidos na patogênese das doenças periodontais. Para o segundo objetivo, foram obtidas amostras teciduais da mucosa mastigatória de 4 pacientes com histórico de periodontite crônica, 4 com periodontite agressiva generalizada e 4 indivíduos sem histórico de periodontite. As amostras foram manipuladas para a extração de RNA total, síntese de cDNA de fita dupla e a hibridização por microarranjo de DNA, avaliando a expressão de 45033 genes. Os programas R e Bioconductor foram empregados para realizar a análise de RMA (Robust-Multi-Array), calcular o valor de expressão (fold-change) e o valor de p para comparações múltiplas através do método de Benjamini-Hochberg. O enriquecimento dos dados, através de ontologia gênica e análise de via, foi realizado com o programa de bioinformática DAVID (Database for Annotation, Visualization and Integrated Discovery). Três comparações foram realizadas: comparação 1 (periodontite agressiva x indivíduos sem histórico de periodontite); comparação 2 (periodontite crônica x indivíduos sem histórico de periodontite); e comparação 3 (periodontite crônica x periodontite agressiva). A comparação entre os grupos identificou: 192 genes e 50 grupos diferencialmente expressos na comparação 1, 43 genes e 27 grupos na comparação 2 e 168 genes e 75 grupos na comparação 3. Genes com funções no sistema imune, entre os quais receptores de linfócitos natural killer, foram mais expressos em periodontite agressiva; em contraste, genes envolvidos na proliferação e diferenciação de queratinócitos, assim como genes com função em processos neurais foram menos expressos. Já os indivíduos com periodontite crônica se caracterizaram por um aumento na expressão de genes com função na resposta a estímulos externos, e uma diminuição na expressão dos genes relacionados ao sistema imune. Dentro dos limites desse estudo, pode-se concluir que existem diferenças nos perfis de expressão gênica da mucosa mastigatória de indivíduos com histórico de periodontite agressiva e crônica, quando comparadas entre si e com indivíduos sem histórico de periodontite, que podem estar associadas às diferenças em suas patogêneses
Abstract: Aggressive periodontitis is characterized by early onset, rapid progression and poor response to treatment compared to chronic periodontitis. However, mechanisms responsible for these differences are not fully understood. Tools such as genomics, proteomics and transcriptomics can clarify these aspects, producing important information about the pathogenesis of periodontal diseases. Therefore, the aims of this study were: i) Provide a literature review focused on the application of genomics, transcriptomics, proteomics, and metabolomics in the study of periodontal diseases. ii) Evaluate the gene expression profile of tissue from masticatory mucosa, without the influence of biofilm, in patients with a history of generalized aggressive and chronic periodontitis, and also with gene expression profile of individuals without periodontitis, with the aim to identify possible constitutive alterations in gene expression, which may be related to the differences between both forms of periodontitis. For the first objective, it was performed a review of articles that employed omics technologies in the study of periodontal diseases. The studies in the literature indicated that these technologies can lead to a better understanding of molecular events involved in the pathogenesis of periodontal diseases. For the second objective, masticatory mucosa tissue samples were obtained from 4 patients with a history of chronic periodontitis, 4 with generalized aggressive periodontitis, and 4 from subjects without history of periodontitis. Tissue samples were processed for total RNA extraction, double-strand cDNA synthesis for subsequent hybridization reaction on microarrays, which assessed the expression of 45033 genes. R and Bioconductor softwares used to perform the RMA analysis (Robust Multi-Array), calculate the value of expression (fold-change) and the p-value for multiple comparisons through Benjamini-Hochberg method. Enrichment analysis, through gene ontology (GO) and pathway analysis, was performed with DAVID (Database for Annotation, Visualization and Integrated Discovery). Three comparisons were performed: comparison 1 (aggressive periodontitis x healthy subjects); comparison 2 (chronic periodontitis x healthy subjects); and comparison 3 (chronic periodontitis x aggressive periodontitis). Comparisons analysis found 192 genes and 50 groups differentially expressed in comparison 1, 43 genes and 27 groups in comparison 2, and 168 genes and 75 groups in comparison 3. Genes with function in the immune system, including natural killer cells receptors, were higher expressed in aggressive periodontitis; in contrast, genes involved in proliferation and differentiation of keratinocytes, as well as genes with function in neural process were lower expressed. Chronic periodontitis subjects were characterized by increased expression of genes related to response to external stimuli, and a decrease in the expression of genes related to the immune system. Within the limits of this study, it can be concluded that there are differences in the gene expression profile of masticatory mucosa of patients with a history of chonic and aggressive periodontitis, when compared among them and with healthy group, which may be associated with differences in their pathogenesis
Mestrado
Periodontia
Mestre em Clínica Odontológica

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Rêgo, Rodrigo Otávio Citó César [UNESP]. "Estudo comparativo das condições clínicas periodontais e da prevalência de periodontopatógenos suspeitos entre mães e filhos." Universidade Estadual Paulista (UNESP), 2002. http://hdl.handle.net/11449/96218.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Os objetivos deste estudo foram comparar as condições clínicas periodontais e a prevalência de periodontopatógenos entre mulheres com periodontite crônica severa e seus filhos. Participaram deste estudo vinte mães com idade média de 36,6 anos (desvio padrão = 6,7) e um filho de cada uma destas com idade média de 11,8 anos (desvio padrão = 3,4). Foram analisadas as correlações entre a presença de placa visível (PV), sangramento marginal (SM), profundidade de sondagem >= 6mm e nível de inserção clínico >= 5mm das mães e PV e SM dos filhos e a associação da extensão e severidade da doença periodontal nas mães com a presença de perda de inserção clínica de 4 mm nos filhos. A avaliação microbiológica foi realizada através de cultura bacteriana de amostras colhidas de sítios periodontais para comparar a prevalência de Porphyromonas gingivalis, Prevotella sp., Fusobacterium sp., Peptostreptococcus micros, Capnocytophaga sp., Campylobacter sp. e Eikenella corrodens nas mães e nos filhos. Não foi observada nenhuma correlação significante entre os parâmetros clínicos das mães e dos filhos assim como não foi encontrada associação significante entre a presença de perda da inserção clínica de 4 mm nos filhos e a extensão e severidade da doença das mães. A presença dos periodontopatógenos nas mães não esteve associada com a presença destes em seus filhos.
The aims of this study were to compare the periodontal clinical conditions and the prevalence of periodontopathogens in mothers with chronic servere periodontitis and their children. Twenty women (mean age = 36,6; SD = 6,7) and one child of each (mean age = 11,8; SD = 3,4) participated in this study. Correlations between the following clinical parameters of the mothers: presence of visible plaque (VP), marginal bleeding (MB), probing depth >= 6 mm and clinical attachment loss >= 5mm and the presence of VP and MB on their sons were assessed, as well as the association between the extent and severity of the periodontal disease present in the mothers with the presence of CAL of at least 4 mm in the children. The microbiological evaluation was performed by culturing samples of subgingival bacterial plaque collected both from mothers and children in order to compare the prevalence of Porphyromonas gingivalis, Prevotella sp., Fusobacterium sp., Peptostreptococcus micros, Capnocytophaga sp., Campylobacter sp. and Eikenella corrodens. No significant correlations were found neither between clinical parameters of mothers (VP, MB, PD, CAL) and children (VP, MB), nor between the extent and severity of periodontal disease in the mothers and presence of CAL of at least 4 mm in the children. The prevalence of any of the periodontopathogens screened in this study in the plaque samples from mothers was also not associated with its presence in plaque samples from their children.

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Ferreira, Camila Lopes. "Efeito concomitante da doença periodontal induzida e movimentação ortodôntica em ratos submetidos à inalação da fumaça de cigarro : estudo histomorfométrico /." São José dos Campos, 2016. http://hdl.handle.net/11449/132958.

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Orientador: Maria Aparecida Neves Jardini
Co-orientador: Milton Santamaria Junior
Banca: Cibelle Barbosa Lopes
Banca: Weber José da Silva Ursi
Resumo: Este estudo avaliou as reações do tecido periodontal em ratos submetidos à inalação da fumaça de cigarro associado à doença periodontal e movimentação dentária induzida experimentalmente. Sessenta animais com 90 dias de idade e pesando em média 300g foram separados aleatoriamente nas condições fumantes (n=30) e não fumantes (n=30). Independente da condição sistêmica atribuída, 15 animais receberam na hemimandíbula direita a indução da doença periodontal juntamente com a movimentação ortodôntica (DP+O) e a hemimandíbula esquerda do mesmo animal foi induzida somente a doença periodontal (DP) por meio de ligadura. Outros 15 animais receberam na hemimandíbula direita somente a movimentação ortodôntica (O) e a hemimandíbula esquerda serviu como controle positivo (C+). A exposição à fumaça de cigarro foi iniciada dois meses antes e manteve-se por todo o período experimental até o sacrifício. Foi obtida medida macroscópica para a movimentação dentária imediatamente após o sacrifício. As lâminas foram confeccionadas e coradas em HE. Foi avaliada a área da perda óssea na região de furca do primeiro molar inferior e a densidade óssea, região considerada 1000 μm abaixo da crista óssea interradicular. Foi aplicado o teste de normalidade Shapiro-Wilk de igualdade de variâncias e utilizado o teste ANOVA de dois fatores com nível de significância de 5 %. Não houve diferença estatisticamente significante entre fumante e não fumante. A perda óssea entre DP e DP+O não apresentou significância entre si, diferenciando-se ambas de O e C+. Na densidade óssea DP+O foi diferente apenas para o controle. Na movimentação dentária, DP+O foi maior e significante que nas demais situações, porém não houve diferença entre DP+O e O na condição fumante. Portanto, concluímos que a inalação da fumaça de cigarro não teve influência nos grupos avaliados. Porém, a doença periodontal induzida, associada...
Abstract: This study evaluated the reactions of periodontal tissue in rats exposed to inhalation of cigarette smoke associated with periodontal disease and tooth movement induced experimentally. Sixty animals at 90 days of age and weight approximately 300g were randomly separated in smokers (n= 30) and non-smokers (n = 30) conditions. Regardless of systemic condition, 15 animals received in the right hemimandible induction of periodontal disease with orthodontic movement (PD+O) and left hemimandible of the same animal was only induced periodontal disease (PD) by ligature. Another 15 animals received the right hemimandible only orthodontic movement (O) and left hemimandible served as positive control (C+). Exposure to cigarette smoke was started two months before and was kept throughout the trial period until the sacrifice. Immediately after sacrifice, a macroscopic measure was done, which was called tooth movement, realized by a caliper rule. The slices were prepared and stained with HE. Bone loss area was evaluated in the furcation region of the first molar and bone density, and it was considered 1000 μm below the of the interradicular bone crest. The Shapiro-Wilk normality test of equal variances was applied. So we used the ANOVA two factors with 5 % significance level. There was no statistically significant difference between smokers and nonsmokers. Bone loss between PD and PD+O showed no difference between themselves, but were different from O and C+, in both. The bone density was different DP+O only the control. On tooth movement measure, DP+O were higher and significant than in the others situations, but there was no difference between DP+O and O in smoker condition. Therefore, we conclude that inhalation of cigarette smoke did not influence the evaluation groups. But, the induced periodontal disease, with or without orthodontic tooth movement, caused increased bone loss in both groups
Mestre

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Prado, Rosana Leal do. "Avaliação da sensibilidade à insulina e transdução do sinal insulínico em ratos adultos, proles de ratas com doença periodontal /." Araçatuba, 2008. http://hdl.handle.net/11449/95422.

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Orientador: Doris Hissako Sumida
Banca: Marília Afonso Rabelo Buzalaf
Banca: Suzely Adas Saliba Moimaz
Resumo: Nos dias atuais, a crescente incidência de diabetes mellitus no mundo torna fundamental a idéia de se identificar fatores de risco que levam ao desenvolvimento da doença e proporcionar sua prevenção. Diversos estudos têm levado a considerar as condições bucais não mais de maneira isolada, mas em suas relações com o corpo humano. Este posicionamento também é válido para as periodontopatias, que têm sido apontadas por diversos estudos como fator de risco para o desenvolvimento de doenças, entre elas o parto prematuro de bebês com baixo peso e o diabetes mellitus. O nascimento prematuro sobressai‐se como o maior problema peri‐natal em muitos países, contribuindo substancialmente para a mortalidade infantil e para o desenvolvimento de uma infância repleta de problemas. Há ainda estudos que apontam que adultos que nasceram com baixo peso tem um maior risco de desenvolver diabetes mellitus na vida adulta. A revisão destes estudos demonstra a inter‐relação entre estas doenças e alguns dos mecanismos biológicos envolvidos, buscando alertar quanto ao estilo de vida propício ao desenvolvimento de periodontopatias e a busca por hábitos preventivos, além da necessidade de mais estudos para elucidar os mecanismos envolvidos nesta inter‐relação.
Abstract: Currently, the increasing incidence of diabetes mellitus in the world makes the idea of identifying risk factors which can lead to the development of the disease and ways to prevent it as an important matter. Several studies have considered oral conditions in an integrated approach with the general health conditions. This approach is also valid for periodontal diseases, which have been pointed as a risk factor for the development of some diseases, like preterm birth, low weight babies and diabetes mellitus. Premature birth has been pointed out as the major prenatal problem in several countries, contributing substantially with infant mortality and the development of other infant problems. There are also studies showing that adults with a preterm birth history have a higher risk of developing diabetes mellitus. The review of these researches demonstrate the inter‐relation between these diseases and some of the involved biological mechanisms, aiming to alert population about life style conditions which can lead to periodontal diseases and also to promote preventive measures, as well as the need of more studies to elucidate the involved mechanisms of this inter‐relation.
Mestre

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Almeida, Juliano Milanezi de. "Avaliação histológica e histométrica da terapia fotodinâmica no tratamento da doença periodontal experimental induzida em ratos diabéticos e não diabéticos /." Araçatuba, 2007. http://hdl.handle.net/11449/104713.

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Orientador: Valdir Gouveia Garcia
Coorientador: Letícia Helena Theodoro
Banca: Maria José Hitomi Nagata
Banca: Álvaro Francisco Bosco
Banca: Enilson Antônio Sallum
Banca: Martha Simões Ribeiro
Resumo: O objetivo do presente estudo foi avaliar histológica e histometricamente a influência da terapia fotodinâmica (PDT) no tratamento coadjuvante da doença periodontal (DP) experimental induzida em ratos diabéticos e não-diabéticos. Foram utilizados 180 ratos divididos em 2 grupos: Grupo A: 90 animais não-diabéticos e Grupo B: 90 animais diabéticos induzidos pela aloxana a 2% (42 mg/Kg). Nos Grupos A e B a DP foi induzida no primeiro molar inferior. Após 7 dias de evolução da DP, em todos animais de ambos os Grupos, a ligadura foi removida seguida de raspagem e alisamento radicular (RAR) e divididos conforme os tratamentos: I (RAR) - RAR e irrigação com 1 ml de soro fisiológico; II (TBO) - RAR e irrigação com 1 ml de azul de toluidina O (TBO 100 μg/ml); III (PDT) - RAR, irrigação com 1 ml de TBO e após 1 minuto irradiação com o laser em baixa intensidade. O laser (AsGaAl, 660 nm) foi aplicado na vestibular e lingual em 3 pontos eqüidistantes em cada região, com dose energética de 4 J/ponto. Dez animais de cada grupo experimental e tratamento foram sacrificados nos períodos de 7, 15 e 30 dias para a análise histológica e histométrica. Os dados histométricos foram submetidos à análise estatística (p<0,05). Os animais tratados com a PDT (Grupo A e B), apresentaram histologicamente tecido conjuntivo (TC) bem organizado e trabéculas ósseas presentes em toda a extensão da furca. Nos animais tratados com RAR nos dois grupos, o TC estava desorganizado, com intenso infiltrado inflamatório e áreas de reabsorções ósseas e cementárias. As alterações mais severas foram observadas no Grupo B. Histometricamente, no Grupo A, o tratamento com a PDT (0,33±0,05 mm2; 0,35±0,06 mm2; 0,27±0,07 mm2), promoveu menor perda óssea (p<0,05) na região de furca quando comparado com os animais tratados... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The aim of this study was to evaluate histological and histometrically the influence of photodynamic therapy (PDT) as an adjuvant treatment on the experimentally induced periodontitis in diabetic and non-diabetic rats. One-hundred eighty rats were assigned to 2 groups: Group A: Ninety non-diabetic and Group B: Ninety alloxan-diabetic. In Group B, after 7 days of alloxan-diabetic induction (42 mg/Kg), the periodontal disease (PD) was induced at the first mandibular molar. Seven days after the establishment of PD, the ligatures were removed. Thereafter, all animals were submitted to scaling and root planing (SRP) and then divided according with the following protocols treatment: I (SRP) - SRP and irrigation with saline solution (1 mL); II (TBO) - SRP and irrigation with 1 mL of Toluidine Blue (TBO) (100 μg/mL); III (PDT) - SRP, irrigation with 1mL of TBO and after 1 minute, low-level laser therapy (LLLT). The LLLT GaAlAs (4 J) was performed in 3 equidistant points at the each buccal and lingual aspect of the first mandibular molar. Ten animals in each experimental group and treatment were sacrificed at 7, 15 and 30 days. Histologic and histometric analyses were performed. The histometric values were statistical analyzed ( p<0.05). The animals treated by PDT in Group A and B showed the furcation area fulfilled with a well-organized connective tissue (CT) and with bone trabeculae in all extension of furcation. In animals treated with SRP, the CT was poorly organized, showing an intense inflammatory infiltrate and areas with bone and cement resorption. The worst tissue response was found in Group B. Histometrically, in Group A, the animals treated by PDT (0.33±0.05 mm2; 0.35±0.06 mm2; 0.27±0.07 mm2) showed a lesser bone loss (p<0.05) in all experimental... (Complete abstract click electronic access below)
Doutor

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Macarimi, Valmir Campos. "Ação do laser em baixa intensidade no tratamento da doença periodontal induzida em ratos diabéticos e não diabéticos : estudo histológico e histométrico. -." Araçatuba, 2008. http://hdl.handle.net/11449/104718.

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Orientador: Valdir Gouveia Garcia
Banca: Álvaro Francisco Bosco
Banca: Maria José Hitomi Nagata
Banca: Maria Lucia Rubo de Rezende
Banca: José Maria Bertão
Resumo: Objetivo: O objetivo do presente estudo foi avaliar histológica e histometricamente a ação do Laser em baixa intensidade (LLLT) como coadjuvante ao tratamento da doença periodontal induzida em animais diabéticos e não diabéticos. Métodos: Foram utilizados 120 ratos divididos em 2 grupos: Grupo A: 60 animais nãodiabéticos e Grupo B: 60 animais diabéticos induzidos pela aloxana à 2% (42 mg/Kg). Nos animais de ambos os Grupos a doença periodontal (DP) foi induzida no primeiro molar inferior esquerdo. Após 7 dias de evolução da DP, em todos os animais dos Grupos A e B a ligadura foi removida e 30 animais de cada grupo foram submetidos aos seguintes tratamentos: tratamento I (RAR) - raspagem e alisamento radicular e irrigação com 1 ml de solução salina (SS); Tratamento II (LLLT) - RAR + SS seguido da irradiação com laser em baixa intensidade (LLLT). A irradiação laser foi realizada (AsGaAl, 660 nm) em 3 pontos eqüidistantes na face vestibular e 3 pontos eqüidistantes na lingual. Cada ponto recebeu uma energia de 4 J. Dez animais de cada grupo experimental foram sacrificados nos períodos de 7, 15 e 30 dias para a análise histológica e histométrica. Os dados histométricos da perda óssea foram submetidos à análise de variância (p<0,05). Resultados: A áreas de furca tratadas com LLLT nos grupos A e B apresentaram tecido conjuntivo organizado com trabéculas ósseas em toda extensão da furca. Nas áreas tratadas com RAR em ambos os grupos o tecido conjuntivo apresentava-se desorganizado com intenso infiltrado inflamatório e áreas de reabsorções ósseas e cementárias. Histometricamente aos 7, 15 e 30 dias o tratamento RAR nos grupos A... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The aim of this study was to evaluate histological and histometrically the influence of low level laser therapy (LLLT) as an adjuvant treatment on the experimentally induced periodontitis in diabetic and non-diabetic rats. One hundred and twenty rats were assigned to 2 groups as follows: Group A: Sixty nondiabetic rats and Group B: Sixty diabetic animals kept on alloxan-diabetic induction for 7 days(42 mg/ml). In both groups, the periodontal disease (PD) was induced at the first left side mandibular molar. Seven days after the establishment of PD, ligatures were removed from all animals of both groups. Afterwards, 30 animals of each group were submitted following protocol treatments: I (SRP)- SRP and irrigation with saline solution (1mL)(SS). II (SRP+LLLT)- SRP, irrigation with 1 mL with SS plus Low-level laser therapy (LLLT). The LLLT GaAlAs (4 J/cm2) was performed in 3 equidistant points at each bucal and lingual aspect of the first mandibular molar. Each point received 4 J of energy. Ten animals in each experimental treatment group were sacrificed at 7th, 15 th and 30th day of the experiment in order to provide histologic and histometric analyses (p<0,05). Results: The furcations areas treated with LLLT in Groups A and B showed well-organized connective tissue (CT) and bone trabeculae presence in all extension of the furcation. In animals treated with SRP, in both groups, the CT was poorly organized with intense inflamatory infiltrate and areas with bone and cement reabsortion. Histometrically, at the 7th, 15th and 30 th day of SRP treatment, the animals of groups A (1,11±0,11; 0,84±0,12; 0,97±0,13) and B (2,27±0,47; 3,23±0,34; 2,82±0,75) developed significative bone loss (p<0,05) at the furcation area... (Complete abstract click electronic access below)
Doutor

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Johannsen, Annsofi. "Anxiety, exhaustion and depression in relation to periodontal diseases /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-694-8/.

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Alves, Vanessa Tubero Euzébio. "Laser de diodo de alta potência como adjunto ao tratamento periodontal: ensaio clínico randomizado." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/23/23146/tde-09112010-104443/.

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O laser de diodo de alta potência tem sido estudado em Periodontia para redução microbiana como coadjuvante ao tratamento não cirúrgico. O objetivo deste ensaio clínico aleatório de boca-dividida foi avaliar a redução bacteriana e as mudanças nos parâmetros clínicos periodontais promovidas pela raspagem, associada ao laser de diodo de alta potência. Foram selecionados trinta e seis (36) pacientes, de ambos os sexos e portadores de periodontite crônica. Cada paciente forneceu um par de dentes unirradiculares contralaterais com profundidade clínica de sondagem (PCS) 5mm. Os pacientes passaram por tratamento periodontal prévio e em seguida os dentes experimentais foram divididos em dois grupos: teste e controle. Ambos receberam raspagem, alisamento e polimento coronário radicular (RAPCR), sendo que apenas o grupo teste recebeu a irradiação do laser de diodo (1,5W, contínuo, 1.193,7 W/cm2, 20 segundos) em duas sessões, com intervalo de uma semana. Os parâmetros clínicos e microbiológicos foram coletados no início e 6 semanas após o tratamento. Houve redução significativa para todos os parâmetros clínicos estudados em ambos o grupos, entretanto os parâmetros PCS e Nível Clínico de Inserção (NCI) demonstraram melhora estatisticamente significante no grupo controle quando comparado ao grupo teste. Em relação às Unidades Formadoras de Colônias (UFCs) de bactérias totais (BT) e pigmentadas de preto (BPP) foi observada redução em ambos os grupos, porém sem diferença significante entre eles. Não houve diferença significativa entre os grupos em relação à presença de Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) e Prevotella intermedia (P. intermedia), entretanto a redução no número de pacientes que apresentaram Porphyromonas gingivalis (P. gingivalis) foi significativamente maior no grupo controle. Foi concluído que a irradiação do laser de diodo de alta potência, em bolsas de dentes unirradiculares, não proporcionou melhora clínica e microbiológica adicional ao procedimento convencional.
The high intensity diode laser has been studied in periodontics for microbial reduction in non-surgical treatment as an adjunct to scaling procedures. The goal of this randomized clinical trial was to assess the bacterial reduction and changes in clinical periodontal parameters promoted by scaling, combined with high intensity diode laser. Thirty six (36) subjects, of both gender and with chronic periodontitis were selected. Each patient provided a pair of contra-lateral singles rooted teeth, with probing pocket depth (PPD) 5 mm. Patients underwent periodontal treatment prior and then the teeth were divided into two experimental groups: test and control. Both received scaling and root planing (SRP), and only the test group received irradiation of diode laser (1.5W, continuous, 1.193,7 W/cm2, 20 seconds) in two sessions, with break of one week. Clinical and microbiological data were collected at baseline and 6 weeks after treatment. There was a significant decrease for all clinical parameters studied in both groups, but the parameters PPD and clinical attachment level (CAL) showed statistically significant improvement in the control group compared to the test group. Concerning Colony Forming Units (CFU) of total bacteria and black pigmented colonies, reduction was observed in both groups but no significant difference was observed between them. There was no significant difference between the groups regarding the presence of P. intermedia and A. actinomycetemcomitans, however the decrease in the number of patients who had P. gingivalis was significantly higher in the control group. It was concluded that irradiation with the high intensity diode laser, in periodontal pockets of single- rooted teeth, did not provide additional clinical and microbiological improvement.

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Mak, Yiu-fai. "Microbial flora of root canals at the time of obturation and the outcome of treatment." Click to view the E-thesis via HKUTO, 2000. http://sunzi.lib.hku.hk/HKUTO/record/B38628053.

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Salis, Ana Maria Vilela de. "Avaliação da transmissibilidade de microrganismos periodontopatogênicos entre mães e filhos utilizando-se o teste Bana /." Araraquara : [s.n.], 2000. http://hdl.handle.net/11449/95519.

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Orientador: Benedicto Egbert Corrêa de Toledo
Banca: Rita de Cássia Loiola Cordeiro
Banca: Marcelo Fava de Moraes
Resumo: Descobertas recentes sugerem que microrganismos periodontopatogênicos são transmitidos entre membros de uma mesma família, pois há verificações da semelhança de linhagens de bactérias obtidas de seus integrantes, principalmente da mãe. Assim, o objetivo foi verificar se havia alguma correlação significativa entre os resultados do Teste BANA (Perioscan), obtidos em amostras de placa dentária subgengival de 54 crianças, entre 6 e 9 anos, e suas mães, todos residentes no município de Barretos-S.P. As amostras de placa subgengival foram colhidas com curetas periodontais de 432 sítios. Após a análise dos dados, os resultados do Teste BANA demonstraram que 67 sítios de crianças (31%) apresentaram reatividade positiva, enquanto que nas mães o número foi de 85 (39,3%). Em relação a negatividade do BANA nas crianças e suas mães, foi, respectivamente, de 149 (69%) e de 131 (60,7%) sítios, o que demonstrou a existência de uma relação estatisticamente significativa entre as variáveis BANA de mãe e filho. Os resultados do presente estudo permitiram sugerir que a presença de bactérias periodontopatogênicas nos filhos está relacionada à presença das mesmas bactérias nas mães, e que possível relacionamento de alterações periodontais nas mães podem representar significado importante no estabelecimento das patologias periodontais nos filhos.
Abstract: Recent researchs suggest that periodontophatogens microrganisms are transmitted among the members of the same family, because it could be observed the likeness of the lineages of obtained from bacterias of family members, mainly of the mother. The purpose of this study was to verify if there was some significant correlation between the results of the Test BANA (Perioscan), obtained in samples of subgingival dental plaque of 54 children between 6 and 9 years and their mothers, resident in the municipal district Barretos-S.P. The samples of the subgingival plaques were picked up with periodontal instruments in 432 sites. After the statistical analysis of the data, the BANA Test results showed that in the children 67 (31%) of the sites presented positive reactivity while in the mothers 85 (39,3%) and in relation to the negativity of the BANA test, it was 149 (69%) e 131 (60,7%) respectivilly, this showed a statistically significant relationship between mother's and son BANA variable. The results of the present study let us to suggest that the presence of bacterial periodontophatogens in the children is related with the presence of the same bacterias in their mothers, and that a possible relationship of the periodontal alterations in the mothers can be an important factor in the establishement of periodontal pathologies in children.
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Carvalho, Veronica Franco de. ""Avaliação da cooperação com os retornos de controle e manutenção periodontal dos pacientes da clínica de pós-graduação da FOUSP"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/23/23146/tde-22052006-114225/.

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Estudos mostram um baixo grau de cooperação aos retornos de pacientes em controle e manutenção. Com o intuito de avaliar a cooperação dos pacientes da FOUSP, este trabalho foi dividido em duas fases: estudo transversal e estudo intervencional. A primeira análise revelou uma participação insatisfatória dos pacientes no Programa de Controle e Manutenção da Disciplina de Periodontia, durante 5 anos. Dos 402 indivíduos avaliados, 18,2% eram cooperadores completos, 8,2% eram irregulares e 73,6% abandonaram o programa. A partir desses grupos, foi realizado um estudo intervencional em 137 pacientes, que objetivou avaliar a influência de um método para melhorar a cooperação com o controle e manutenção. Durante 12 meses, o grupo Cooperação Completa recebeu os procedimentos habituais de uma consulta de Controle e Manutenção; o grupo Cooperação Irregular recebeu procedimentos habituais e motivação para aumentar sua cooperação; o grupo Nenhuma Cooperação recebeu cartas para incentivar seu retorno, sendo que, aqueles que retornaram ao programa receberam o mesmo tratamento do grupo Cooperação Irregular. Neste período de intervenção, a taxa de cooperação completa aumentou de 50,4% para 67,9%. Não houve associação entre gênero e grau de cooperação, não houve diferença significante entre os grupos de cooperação em relação à idade. Os resultados mostraram que o método empregado teve influência favorável sobre o grau de cooperação dos pacientes.
Previous studies have found poor patient compliance with periodontal maintenance therapy. In order to assess compliance with periodontal maintenance in University of São Paulo, this study was divided in two parts: cross-sectional study and intervention study. The cross-sectional analysis showed unsatisfactory compliance with maintenance program from the Graduate Periodontal Clinic, during 5 years. From 402 subjects evaluated, 18.2% were complete compliers, 8.2% were irregular compliers and 73.6% were non-compliers. A intervention study was undertaken with 137 patients chosen from those groups. The aim of this study was to assess the influence of a method to improve patients compliance with periodontal maintenance. In a period of 12 months, the complete compliance group received usual procedures of a maintenance visit; the irregular compliance group received usual procedures and motivation to change its behavior; to the non-compliers patients letters were sent in order to motivate them to resume the program, and those who returned received the same procedures as the irregular group. The degree of complete compliance increased from 50,4% to 67,9%, during the course of the second study. There was no correlation between gender and compliance. There was no significant difference in compliance in relation to age. The results showed that the method applied had favorable influence over the patients compliance.

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Macarimi, Valmir Campos [UNESP]. "Ação do laser em baixa intensidade no tratamento da doença periodontal induzida em ratos diabéticos e não diabéticos: estudo histológico e histométrico. -." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/104718.

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Made available in DSpace on 2014-06-11T19:33:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-02-11Bitstream added on 2014-06-13T18:45:13Z : No. of bitstreams: 1 macarimi_vc_dr_araca.pdf: 595907 bytes, checksum: 1710f2019435e1c764684ca6a7fe12b2 (MD5)
Objetivo: O objetivo do presente estudo foi avaliar histológica e histometricamente a ação do Laser em baixa intensidade (LLLT) como coadjuvante ao tratamento da doença periodontal induzida em animais diabéticos e não diabéticos. Métodos: Foram utilizados 120 ratos divididos em 2 grupos: Grupo A: 60 animais nãodiabéticos e Grupo B: 60 animais diabéticos induzidos pela aloxana à 2% (42 mg/Kg). Nos animais de ambos os Grupos a doença periodontal (DP) foi induzida no primeiro molar inferior esquerdo. Após 7 dias de evolução da DP, em todos os animais dos Grupos A e B a ligadura foi removida e 30 animais de cada grupo foram submetidos aos seguintes tratamentos: tratamento I (RAR) – raspagem e alisamento radicular e irrigação com 1 ml de solução salina (SS); Tratamento II (LLLT) - RAR + SS seguido da irradiação com laser em baixa intensidade (LLLT). A irradiação laser foi realizada (AsGaAl, 660 nm) em 3 pontos eqüidistantes na face vestibular e 3 pontos eqüidistantes na lingual. Cada ponto recebeu uma energia de 4 J. Dez animais de cada grupo experimental foram sacrificados nos períodos de 7, 15 e 30 dias para a análise histológica e histométrica. Os dados histométricos da perda óssea foram submetidos à análise de variância (p<0,05). Resultados: A áreas de furca tratadas com LLLT nos grupos A e B apresentaram tecido conjuntivo organizado com trabéculas ósseas em toda extensão da furca. Nas áreas tratadas com RAR em ambos os grupos o tecido conjuntivo apresentava-se desorganizado com intenso infiltrado inflamatório e áreas de reabsorções ósseas e cementárias. Histometricamente aos 7, 15 e 30 dias o tratamento RAR nos grupos A...
The aim of this study was to evaluate histological and histometrically the influence of low level laser therapy (LLLT) as an adjuvant treatment on the experimentally induced periodontitis in diabetic and non-diabetic rats. One hundred and twenty rats were assigned to 2 groups as follows: Group A: Sixty nondiabetic rats and Group B: Sixty diabetic animals kept on alloxan-diabetic induction for 7 days(42 mg/ml). In both groups, the periodontal disease (PD) was induced at the first left side mandibular molar. Seven days after the establishment of PD, ligatures were removed from all animals of both groups. Afterwards, 30 animals of each group were submitted following protocol treatments: I (SRP)- SRP and irrigation with saline solution (1mL)(SS). II (SRP+LLLT)- SRP, irrigation with 1 mL with SS plus Low-level laser therapy (LLLT). The LLLT GaAlAs (4 J/cm2) was performed in 3 equidistant points at each bucal and lingual aspect of the first mandibular molar. Each point received 4 J of energy. Ten animals in each experimental treatment group were sacrificed at 7th, 15 th and 30th day of the experiment in order to provide histologic and histometric analyses (p<0,05). Results: The furcations areas treated with LLLT in Groups A and B showed well-organized connective tissue (CT) and bone trabeculae presence in all extension of the furcation. In animals treated with SRP, in both groups, the CT was poorly organized with intense inflamatory infiltrate and areas with bone and cement reabsortion. Histometrically, at the 7th, 15th and 30 th day of SRP treatment, the animals of groups A (1,11±0,11; 0,84±0,12; 0,97±0,13) and B (2,27±0,47; 3,23±0,34; 2,82±0,75) developed significative bone loss (p<0,05) at the furcation area... (Complete abstract click electronic access below)

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39

Ajwani, Shilpi. "Periodontal disease in an aged population, and its role in cardiovascular mortality." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/hamma/vk/ajwani/.

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40

Persson, Lena. "Tobacco smoking, vascular reaction and neutrophil activity in periodontal health and disease." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-404-6.

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41

Nishiyama, Sheila Alexandra Belini. "Possíveis impactos da cirurgia bariátrica sobre a saúde periodontal de indivíduos obesos. Determinação do perfil microbiológico e imunológico." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/42/42132/tde-26062014-141424/.

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O presente trabalho teve por objetivo avaliar a microbiota subgingival pela técnica de Checkerboard e o perfil de citocinas por imunoensaio com princípio sanduíche baseado na tecnologia fluxometria do fluido gengival e soro em indivíduos não obesos; e em indivíduos com obesidade, antes e após cirurgia bariátrica. Diferenças na microbiota bucal foram observadas entre não obesos e obesos para 19 espécies bacterianas, particularmente E. corrodens que apresentou diferenças significativas em obesos, com consequente redução após a perda de peso. As citocinas IL-1b, IL-6, IL-10, IL-13, IL-17, TNF-a, leptina e adiponectina apresentaram diferenças estatisticamente significantes (p<0,05) quando esses indivíduos foram comparados. Todas as citocinas analisadas no soro diminuíram após a redução de peso, apenas a adiponectina apresentou concentrações significativamente mais elevadas (p<0,05). Assim, a obesidade promove alterações na microbiota subgengival e na resposta imunológica local e sua prevenção ou controle pode favorecer a saúde bucal.
In this study, the aimed to evaluate the subgingival microbiota using Checkerboard technique and the cytokines profile by using immunoassay based on the flowmetry gingival fluid and serum in non-obese and obese individuals, before and after bariatric surgery. Differences were observed in the oral microbiota between nonobese and obese for 19 bacterial species, particularly E. corrodens that showed significant differences in obese, with a consequent reduction after weight loss. The cytokines IL-1b, IL-6, IL-10, IL-13, IL-17, TNF-a, leptin and adiponectin were statistically different (p <0.05) when these individuals were compared. All analyzed cytokines in serum decreased after weight reduction only adiponectin concentrations showed significantly higher (p <0.05). Thus, obesity causes changes in the subgingival microbiota and the local immune response, and prevention and control can promote oral health.

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42

Boström, Lennart. "Tobacco smoking and periodontal disease : some clinical, microbiological and immunological aspects /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4456-3/.

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43

Engström, Per-Erik. "Mucosal and systemic antibody networks with special emphasis on IgA subclasses." Stockholm : Department of Clinical Immunology and the Department of Periodontology, Karolinska Institute, 1993. http://catalog.hathitrust.org/api/volumes/oclc/28436118.html.

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44

Lengheden, Annelie. "Periodontal implications of calcium hydroxide treatment." Stockholm : Dept. of Oral Diagnosis, Karolinska Institutet, 1994. http://books.google.com/books?id=zfJpAAAAMAAJ.

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45

Ribas, Marcelo Ekman. "Inter-relação entre doença periodontal e déficit cognitivo em ratos Wistar." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/179800.

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As evidências científicas recentes vêm demonstrando uma possível associação entre doenças periodontais e patologias neurodegenerativas como a Doença de Alzheimer. O corpo de evidências vem aumentando consideravelmente nos últimos anos, entretanto, existem poucos estudos de caráter experimental, observando os mecanismos biológicos que podem explicar essa associação. A presente tese teve como objetivo principal analisar, em modelo animal, a associação entre doença periodontal e déficit cognitivo. Nesse contexto, foram produzidos 3 artigos científicos, sendo uma revisão da literatura e 2 estudos experimentais. A revisão de literatura de caráter informativo para os cirurgiõesdentistas buscou avaliar a literatura atual acerca da relação entre as doenças periodontais e Doença de Alzheimer (DA). Pode-se observar que há uma escassa literatura tangente ao tema, com uma ascensão marcante recente de estudos de caráter observacionais transversais, com poucos estudos experimentais clínicos e em modelo animal. A análise dessa literatura demarca o tópico como de notável relevância atual, sendo a DA uma patologia de caráter progressivo e alta morbidade, e as patologias periodontais tornandose um possível fator modulador da etiopatogênese do Alzheimer. Contudo, ainda há carência de estudos experimentais que expliquem melhor os mecanismos biológicos dessa relação e o efeito sistêmico plausível entre as duas patologias. O segundo e terceiro artigos trataram da realização de um modelo experimental, em ratos Wistar, de indução de periodontite e indução de déficit cognitivo, analisando a influência que a doença periodontal pode apresentar sobre a progressão do déficit cognitivo, analisados por modelos comportamentais de retenção de memória (artigo 2) e por parâmetros químicos de estresse oxidativo em nível cerebral (artigo 3). No segundo artigo foram utilizados 30 ratos Wistar machos, com 45 dias de vida, divididos em 3 grupos experimentais. O grupo escopolamina recebeu indução de déficit cognitivo por escopolamina (3mg/kg), e os grupos doença periodontal e escopolamina, receberam indução de perda óssea por meio de ligaduras e indução de déficit cognitivo, sendo um dos grupos avaliado pelo teste comportamental de labirinto aquático de Morris, e o outro avaliado pelo teste comportamental de esquiva inibitória. Os animais com doença periodontal apresentaram piores retenção de memória de curta e longa duração, contudo, de forma não significativa. Pode-se concluir que nesse modelo experimental, a periodontite não foi capaz de modificar a latência de memória avaliada pelos testes comportamentais. Para o terceiro 9 artigo, 40 ratos Wistar foram divididos em 4 grupos experimentais. Grupo controle, grupo doença periodontal (DP), sendo realizada indução de perda óssea alveolar por ligadura, grupo escopolamina, sendo realizada indução de déficit cognitivo por escopolamina (3mg/kg) e grupo DP + escopolamina. Além da análise morfométrica da perda óssea alveolar, foram realizadas análises bioquímicas do tecido cerebral para aferição de estresse oxidativo. Os dados bioquímicos de alterações relacionadas ao estresse oxidativo evidenciam que a presença da doença periodontal induzida foi capaz de modificar significativamente os parâmetros de glutationa reduzida (GSH) e sulfidrilas totais, tanto no grupo somente com doença periodontal em relação ao controle, como no grupo de indução de déficit cognitivo e doença periodontal (DP+Escopolamina). Pode-se concluir que a periodontite induzida foi capaz de modular o déficit cognitivo, diminuindo a ação de agentes antioxidantes em nível cerebral, no modelo experimental proposto. A partir dos resultados dos artigos e frente às reflexões evidenciadas, pode-se concluir que a doença periodontal apresenta um potencial modulador da etiopatogênese de doenças neurodegenerativas como a DA, todavia, uma análise crítica deve ser empregada pelos profissionais sobre os mecanismos que interligam as duas patologias, bem como novos estudos devem ser estimulados para melhor entendimento dos fatores etiopatogênicos que tangem as doenças periodontais e desordens neurodegenerativas.
Recent scientific evidence has demonstrated a possible association between periodontal diseases and neurodegenerative diseases such Alzheimer's. The body of evidence has increased considerably in recent years, however, there are few experimental studies, observing the biological mechanisms possible explaining this association. The main objective of this thesis was to analyze, in an animal model, the association between periodontal disease and cognitive deficit. In this context, 3 scientific articles were written, being a review of the literature and 2 experimental studies. The review of informative literature for practicing dentists sought to evaluate the current literature on the relationship between periodontal diseases and Alzheimer's disease (AD). It can be observed that there is a scarce literature tangent to the subject, with a recent marked rise in cross-sectional observational studies, with few clinical and animal models. The analysis of literature demarcates the topic with outstanding current relevance, being AD a progressive pathology with high morbidity, and periodontal pathologies becoming a possible modulating factor of Alzheimer's disease etiopathogenesis. However, there is still a lack of experimental studies that could better explain the biological mechanisms of this relationship and the plausible systemic effect between the two pathologies. The second and third articles related the development of an experimental model, in Wistar rats, of induction of periodontitis and induction of cognitive deficit, analyzing the influence that periodontal disease may present on the progression of cognitive deficit, analyzed by behavioral models of retention of memory (article 2) and chemical parameters of oxidative stress in brain (article 3). In the second article, 30 male Wistar rats 45 days-old, were divided into 3 experimental groups. The scopolamine group received induction of a scopolamine cognitive deficit (3mg / kg), and the periodontal disease and scopolamine groups received induction of bone loss with ligatures and induction of cognitive deficit, one of the groups being evaluated by Morris aquatic maze, and the group evaluated by the step-down behavioral test. Animals with periodontal disease presented worse short and long term memory retention, however, nonsignificantly. It can be concluded that in this experimental model, periodontitis was not able to modify the memory latency evaluated by the behavioral tests. For the third article, 40 Wistar rats were divided into 4 other experimental groups. A control group, group periodontal disease (PD), with induction of alveolar bone loss by ligature, scopolamine 11 group, with induction of cognitive deficit by scopolamine (3mg / kg) and group DP + scopolamine. In addition to morphometric analysis of alveolar bone loss, biochemical analyzes of the brain tissue were performed to assess oxidative stress. The biochemical data of alterations related to oxidative stress showed that the presence of periodontal disease was able to significantly modify the parameters of reduced glutathione (GSH) and total sulfhydryl, both in the group with periodontal disease in relation to the control, and in the group of induction of cognitive deficit and periodontal disease (PD + Scopolamine). It can be concluded that the induced periodontitis was able to modulate the cognitive deficit, reducing the action of antioxidant agents in cerebral level, in the proposed experimental model. From the results of the articles and the reflections shown, it can be concluded that periodontal disease presents a potential modulator role of the etiopathogenesis of neurodegenerative diseases such AD, however, a critical analysis are stimulated for professionals on the mechanisms that interconnect the two pathologies, as well new studies should be stimulated to better understand the etiopathogenic factors that affect periodontal diseases and neurodegenerative disorders.

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46

Ye, Ping. "Autoimmunity In Chronic Periodontitis." Thesis, The University of Sydney, 2003. http://hdl.handle.net/2123/4872.

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47

Mayfield, Lisa. "Regeneration in periodontal and endosseous implant treatment." Malmö, Sweden : Dept. of Periodontology, Faculty of Odontology, Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/39457632.html.

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48

Dourado, Bianca Maria Ramos. "Doença periodontal em gestantes e repercussões gestacionais e ao recém-nascido." Botucatu, 2018. http://hdl.handle.net/11449/155852.

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Orientador: Cátia Regina Branco da Fonseca
Resumo: A Doença Periodontal na gestação desencadeia uma resposta imunológica exacerbada com altas concentrações locais e sistêmicas de marcadores inflamatórios. Objetivo: Investigar a repercussão da Doença Periodontal (DP) na gestante e suas complicações na gestação e no momento do parto, bem como desfechos negativos para o recém-nascido (RN) (infecção, prematuridade, baixo peso, restrição de crescimento fetal). Método: Estudo de coorte retrospectiva, a partir de registros de prontuários médicos de 142 gestantes atendidas em serviço de pré-natal de risco habitual entre 2012-2014, com avaliação odontológica para DP. Foram analisadas variáveis maternas gestacionais, do parto e do recém-nascido. Os RN foram estratificados em dois grupos: filhos de mães com DP (subdividido para Doença Periodontal grave -DPG) e, filhos de mães sem DP. Cada desfecho foi ajustado por um modelo de regressão logística múltipla, com significância se p<0,05, considerando todos os potenciais confundidores. Resultados: Observou-se entre as mulheres com diagnóstico de DPG o aumento de chance de vulvovaginite 3,45 vezes maior (OR=3,45; p=0,050) e de RPM 5,59 vezes maior (OR=5,59; p=0,017). Nos recém-nascidos, a chance de haver restrição de crescimento fetal foi 11,53 vezes maior nas gestantes com DPG (OR = 11,53; p=0,041). Conclusão: A Doença Periodontal aumentou a chance para desfechos neonatais e maternos negativos, sendo estes o recém-nascido nascer com restrição de crescimento fetal e a gestante apresentar vul... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The Periodontal Disease on pregnancy triggers an intense immunological response with high levels of local and systemic concentration of stress biomarkers. Objective: To investigate the repercussion of periodontal disease (PD) on the pregnant woman and complications during pregnancy and delivery as well, negative outcomes for the newborn (infection, prematurity, low weight, fetal growth restriction). Method: Retrospective cohort study, based on records of medical records of 142 pregnant women attended at prenatal service at usual risk between 2012-2014, with odontological evaluation for PD. Gestational maternal, labor and newborn variables were analyzed. The newborns were stratified into two groups: newborns mothers with PD (subdivided for severe periodontal disease - SPD) and newborns mothers without PD. Each outcome was adjusted by a multiple logistic regression model, with significance if p <0.05, considering all potential confounders. Results: Was increased among women exposed the SPD the odds of vulvovaginitis was 3.45 times higher (OR = 3.45; p=0.050) and of PMR was 5.59 times higher (OR=5.59; p=0.017). In the newborn of mothers exposed the SPD, the increase in odds of the fetal growth restriction was 11.53 times higher (OR=11.53; p= 0.041). Conclusion: Periodontal disease increased the chance for neonatal and maternal negative outcomes, such as fetal growth restriction in the newborn and vulvovaginitis and premature rupture of the membrane in the pregnant woman in the p... (Complete abstract click electronic access below)
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49

Sebbahi, Rajia. "Efficacy of ultrasound imaging to detect periodontal bone defects." Morgantown, W. Va. : [West Virginia University Libraries], 2009. http://hdl.handle.net/10450/10186.

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Thesis (M.S.)--West Virginia University, 2009.
Title from document title page. Document formatted into pages; contains vi, 55 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 42-44).

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50

Brito, Victor Gustavo Balera. "Papel dos mastócitos sobre o metabolismo ósseo local e sistêmico de ratos normotensos e hipertensos com doença periodontal /." Araçatuba, 2018. http://hdl.handle.net/11449/154428.

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Orientadora: Sandra Helena Penha de Oliveira
Banca: Roberta Okamoto
Banca: Pedro Paulo Chaves de Souza
Resumo: Introdução: A doença periodontal (DP) é uma desordem inflamatória dos tecidos de suporte dos dente, iniciada pelo acumulo de biofilme bacteriano, apresentando consequências locais e sistêmicas. A coexistência de doenças sistêmicas, como a hipertensão, pode levar a uma inflamação exacerbada, maior reabsorção óssea e dano sistêmico pronunciado. Além disso, células imunes residentes têm importante papel na progressão da DP, porém, a participação dos mastócitos (MC) ainda não é bem compreendida. Objetivos: Avaliar o papel dos MC sobre o metabolismo ósseo local (mandíbula) e sistêmico (fêmur), em modelo animal normotenso (ratos Wistar) e hipertenso (ratos SHR) com DP. Métodos: Ratos machos Wistar e SHR (10 semanas) foram utilizados. A depleção de MC foi conduzida pelo pré-tratamento com o composto 48/80 e a DP foi induzida por ligadura bilateral nos primeiros molares inferiores, mantida por 15 dias. Foi realizada a identificação de MC no tecido gengival, por coloração com Azul de Toluidina. A perda óssea alveolar e parâmetros de arquitetura óssea na mandíbula e fêmur foram avaliados por microtomografia computadorizada, a expressão gênica de marcadores de formação, remodelamento e reabsorção na mandíbula e fêmur foram avaliada por RT-PCR em tempo real, e a produção de citocinas nos tecidos de interesse foi avaliada por ELISA. Principais resultados: Observamos significativa perda óssea induzida por DP, principalmente no SHR, em comparação ao Wistar, e a depleção de MC foi capaz de p... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Introduction: Periodontal disease (PD) is an inflammatory disorder of the tissues supporting the teeth, which start from the bacterial biofilm accumulation, and results in local and systemic damage. The coexistence of systemic diseases, such as hypertension, can lead to exacerbated inflammation, increased alveolar bone resorption and increased systemic damage. In addition, resident immune cells have an important role in PD progression, however the mast cells (MC) participation is still not well understood. Aims: To evaluate the role of MC in the local (mandible) and systemic (femur) bone metabolism in a normotensive (Wistar) and hypertensive (SHR) rats with PD. Methods: Males Wistar and SHR rats (10-week old) were used. MC depletion was conducted by compound 48/80 treatment and PD was induced by bilateral ligature placed in the lower first molars, which was maintained for 15 days. The identification of MC in the gingival tissue was done by Toluidine Blue staining, alveolar bone loss and bone architecture parameters of mandible and femurs were evaluated by micro-computed tomography, bone markers gene expression on the mandible and femur were evaluated by real time RT-PCR, and the cytokines production was evaluated by ELISA. Key results: We observed a more significant PD-induced bone loss in SHR, compared to Wistar, and MC depletion was able to prevent this loss. PD increased the expression of Opn, Opg/ Rankl/Rank, Trap, Ctsk, Vtn, Itga5 and Itgb5, as well as increased producti... (Complete abstract click electronic access below)
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Dissertations / Theses on the topic 'Periodontal diseases'

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