Journal articles: 'Periodontal Guided Tissue Regeneration'

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Cahaya, Cindy, and Sri Lelyati C. Masulili. "Perkembangan Terkini Membran Guided Tissue Regeneration/Guided Bone Regeneration sebagai Terapi Regenerasi Jaringan Periodontal." Majalah Kedokteran Gigi Indonesia 1, no. 1 (June 1, 2015): 1. http://dx.doi.org/10.22146/majkedgiind.8810.

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Periodontitis adalah salah satu penyakit patologis yang mempengaruhi integritas sistem periodontal yang menyebabkan kerusakan jaringan periodontal yang berlanjut pada kehilangan gigi. Beberapa tahun belakangan ini banyak ketertarikan untuk melakukan usaha regenerasi jaringan periodontal, tidak saja untuk menghentikan proses perjalanan penyakit namun juga mengembalikan jaringan periodontal yang telah hilang. Sasaran dari terapi regeneratif periodontal adalah menggantikan tulang, sementum dan ligamentum periodontal pada permukaan gigi yang terkena penyakit. Prosedur regenerasi antara lain berupa soft tissue graft, bone graft, biomodifikasi akar gigi, guided tissue regeneration sertakombinasi prosedur-prosedur di atas, termasuk prosedur bedah restoratif yang berhubungan dengan rehabilitasi oral dengan penempatan dental implan. Pada tingkat selular, regenerasi periodontal adalah proses kompleks yang membutuhkan proliferasi yang terorganisasi, differensiasi dan pengembangan berbagai tipe sel untuk membentuk perlekatan periodontal. Rasionalisasi penggunaan guided tissue regeneration sebagai membran pembatas adalah menahan epitel dan gingiva jaringan pendukung, sebagai barrier membrane mempertahankan ruang dan gigi serta menstabilkan bekuan darah. Pada makalah ini akan dibahas sekilas mengenai 1. Proses penyembuhan terapi periodontal meliputi regenerasi, repair ataupun pembentukan perlekatan baru. 2. Periodontal spesific tissue engineering. 3. Berbagai jenis membran/guided tissue regeneration yang beredar di pasaran dengan keuntungan dan kerugian sekaligus karakteristik masing-masing membran. 4. Perkembangan membran terbaru sebagai terapi regenerasi penyakit periodontal. Tujuan penulisan untuk memberi gambaran masa depan mengenai terapi regenerasi yang menjanjikan sebagai perkembangan terapi penyakit periodontal. Latest Development of Guided Tissue Regeneration and Guided Bone Regeneration Membrane as Regenerative Therapy on Periodontal Tissue. Periodontitis is a patological state which influences the integrity of periodontal system that could lead to the destruction of the periodontal tissue and end up with tooth loss. Currently, there are so many researches and efforts to regenerate periodontal tissue, not only to stop the process of the disease but also to reconstruct the periodontal tissue. Periodontal regenerative therapy aims at directing the growth of new bone, cementum and periodontal ligament on the affected teeth. Regenerative procedures consist of soft tissue graft, bone graft, roots biomodification, guided tissue regeneration and combination of the procedures, including restorative surgical procedure that is connected with oral rehabilitation with implant placement. At cellular phase, periodontal regeneration is a complex process with well-organized proliferation, distinction, and development of various type of cell to form attachment of periodontal tissue. Rationalization of the use of guided tissue regeneration as barrier membrane is to prohibit the penetration of epithelial and connective tissue migration into the defect, to maintain space, and to stabilize the clot. This research discusses: 1. Healing process on periodontal therapy including regeneration, repair or formation of new attachment. 2. Periodontal specific tissue engineering. 3. Various commercially available membrane/guided tissue regeneration in the market with its advantages and disadvantages and their characteristics. 4. Recent advancement of membrane as regenerative therapy on periodontal disease. In addition, this review is presented to give an outlook for promising regenerative therapy as a part of developing knowledge and skills to treat periodontal disease.

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Villar, Cristina C., and David L. Cochran. "Regeneration of Periodontal Tissues: Guided Tissue Regeneration." Dental Clinics of North America 54, no. 1 (January 2010): 73–92. http://dx.doi.org/10.1016/j.cden.2009.08.011.

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Petrović, Milica, Ljiljana Kesić, Radmila Obradović, Simona Stojanović, Branislava Stojković, Marija Bojović, Ivana Stanković, Kosta Todorović, Milan Spasić, and Nenad Stošić. "Regenerative periodontal therapy: I part." Acta stomatologica Naissi 37, no. 84 (2021): 2304–13. http://dx.doi.org/10.5937/asn2184304p.

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Introduction: Under the concept of regenerative periodontal therapy, there are two approaches: the first is the passive regeneration conceptthat includes bone substituents and guided periodontal regeneration by using of biomembranes and the second concept of active regeneration that impliesthe use of growth factors. The aim of the passive regeneration, by using of bone matrix (bone substituens) has been stabilization and bone defects management, preventing epithelial tissue growth, as well as saving space for the new tissue regeneration. This concept implies the use of autogenous transplantats, xenografts, allografts, as well as alloplastic materials. The carriers for active tissue regeneration, growth factors -GF are biological mediators that regulate cellular processes and that is crucial for the tissue regeneration. Aim:Presentation ofmodern approaches to periodontal therapy thatare focused on the attachment regeneration and complete reconstruction of periodontal tissue. Conclusion: In the future, periodontal regenerative therapy with periodontalligament progenitor cells should encourage repopulation of the areas that have been affected by periodontal disease.

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Bajpai, Devika. "Recent advances in GTR scaffolds." Bioinformation 18, no. 12 (December 31, 2022): 1181–85. http://dx.doi.org/10.6026/973206300181181.

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Periodontitis is a serious chronic inflammatory condition that can cause periodontal tissue deterioration and, eventually, tooth loss. Periodontal regenerative therapy using membranes and bone grafting materials, as well as flap debridement and/or flap curettage, have all been used with varying degrees of clinical effectiveness. Current resorbable and non-resorbable membranes serve as a physical barrier, preventing connective and epithelial tissue down growth into the defect and promoting periodontal tissue regeneration. The "perfect" membrane for use in periodontal regenerative therapy has yet to be created, as these conventional membranes have several structural, mechanical, and bio-functional constraints. We hypothesised in this narrative review that the next-generation of guided tissue and guided bone regeneration (GTR/GBR) membranes for periodontal tissue engineering will be a graded-biomaterials that closely mimics the extracellular matrix.

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Malhotra, Ranjan, Anoop Kapoor, Vishakha Grover, Nitin Verma, and Jasjit Kaur Sahota. "Future of Periodontal Regeneration." Journal of Oral Health and Community Dentistry 4, Spl (2010): 38–47. http://dx.doi.org/10.5005/johcd-4-spl-38.

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ABSTRACT The management of periodontal defects has been an ongoing challenge in clinical periodontics. In the recent past, attention has been focused more on regenerative and reconstructive therapies i.e. bone grafts, guided tissue regeneration, root conditioning, polypeptide growth factors, rather than on respective therapies. These therapeutic measures are shown to be limited in the predictability of healing and regenerative response in the modern clinical practice because oral environment presents several complicating factors that border regeneration. The 21st century appears to represent a time in history when there is a convergence between clinical dentistry and medicine, human genetics, developmental and molecular biology, biotechnology, bioengineering, and bioinformatics, resulting in the emergence of novel regenerative therapeutic approaches viz. tissue engineering, gene therapy and RNA interference. The focus of this review paper is to furnish and update the current knowledge of periodontal tissue engineering, gene therapy and RNA interference i.e. the future of periodontal regeneration.

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Sankhyayan, Dr Akhilesh, Dr Anil Sharma, Vidushi Jindal, Dr Malvika Thakur, Dr Vikas Jindal, and Ayushi Singla. "Guided Tissue Regeneration – A Boon to Surgical Periodontal Therapy." International Journal of Innovative Science and Research Technology 5, no. 7 (July 27, 2020): 471–74. http://dx.doi.org/10.38124/ijisrt20jul416.

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Periodontitis has been a chronic inflammatory disease of the gingiva which eventually result in periodontal pocket formation with loss of the associated periodontal ligament and alveolar bone around teeth. Guided tissue regeneration (GTR), which is often a target for periodontal treatment, has the ability to promote periodontal regeneration. The development of the periodontal attachment is primarily concerned with tissue regeneration.Based on such concept, guided tissue regeneration is being utilized to varying degree of success to restore periodontal defects. In order to remove epithelium as well as gingival corium from the root and/or existing bone walls on the assumption that they interfere with regeneration, barrier techniques have been applied, using elements like expanded polytetrafluoroethylene, polyglactine, polylactic acid, calcium sulfate and collagen.

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Agus Susanto, Susi Susanah, Bambang Pontjo, and Mieke Hemiawati Satari. "MEMBRAN GUIDED TISSUE REGENERATION UNTUK REGENERASI PERIODONTAL." Dentika Dental Journal 18, no. 3 (July 1, 2015): 300–304. http://dx.doi.org/10.32734/dentika.v18i3.1980.

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Berbagai teknik bedah dan bahan terus dikembangkan untuk meningkatkan regenerasi periodontal. Salah satu metode bedahyang sering digunakan pada defek periodontal adalah menggunakan barriermembranguided tissue regeneration (GTR) atauguided bone regeneration (GBR). Prinsip GTR/GBR adalah menggunakan barriermembran untuk menutupi tulang danligamen periodontal, kemudian memisahkannya sementara dari epitel gusi. Fungsi membran ini meningkatkan dan menjagabekuan darah dan bertindak sebagai scaffold untuk perlekatan dan proliferasi sel. Terdapat dua jenis membran yaitumembran non resorbable dan resorbable. Membran non resorbable pada umumnya terbuat dari polytetrafluoroethylene,membran ini sifatnya stabil, nondegradable dan biokompatibel, tetapi penggunaannya memerlukan bedah kedua untukmengambil membran. Membran resorbable berasal dari bahan sintetis seperti polyglycolic, polylactic acid dan bahan alamiseperti kolagen dan laminar bone. Pembuatan membran yang ideal masih terus dikembangkan, membran kolagen saat inilebih sering digunakan karena mempunyai biocompatibility yang optimal walaupun tingkat resorpsi membran sulit untukdiprediksi.

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González-Jaranay, Maximino, María del Carmen Sánchez-Quevedo, Gerardo Moreu, José Manuel García, and Antonio Campos. "Electron Microprobe Analysis in Guided Tissue Regeneration: A Case Report." European Journal of Dentistry 01, no. 01 (January 2007): 40–44. http://dx.doi.org/10.1055/s-0039-1698310.

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ABSTRACTObjectives: Several procedures have been advocated as regenerative procedures in periodontology, but one of the most widely used techniques up to now is guided tissue regeneration (GTR). Likewise, different assessment methods based on clinical, radiographic or histological measurements have been proposed for the evaluation of these regenerative procedures. However, none of the methods used for human material incorporates quantitative X-ray microanalysis to assess the degree of mineralization of the regenerated periodontal hard tissues. The objective of this report was to evaluate, using quantitative X-ray microprobe analysis, the newly-formed hard tissue in a periodontal infrabony defect.Methods: Electron microprobe analysis was used to study the nature of the newly-formed hard tissue 3 years after treatment with guided tissue regeneration in a patient with localized aggressive periodontitis.Results: Our quantitative analyses, using the peak-to-background method, showed calcium/phosphorus mass ratio of 1.50±0.38 in the newly-formed hard tissue around the affected tooth root.Conclusion: Quantitative X-ray microprobe analysis is a useful tool that may provide an accurate assessment of the degree of mineralization in an extremely small tissue sample. (Eur J Dent 2007;1:40- 44)

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Deng, Rong, Yuzheng Xie, Unman Chan, Tao Xu, and Yue Huang. "Biomaterials and biotechnology for periodontal tissue regeneration: Recent advances and perspectives." Journal of Dental Research, Dental Clinics, Dental Prospects 16, no. 1 (May 29, 2022): 1–10. http://dx.doi.org/10.34172/joddd.2022.001.

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Periodontal tissues are organized in a complex three-dimensional (3D) architecture, including the alveolar bone, cementum, and a highly aligned periodontal ligament (PDL). Regeneration is difficult due to the complex structure of these tissues. Currently, materials are developing rapidly, among which synthetic polymers and hydrogels have extensive applications. Moreover, techniques have made a spurt of progress. By applying guided tissue regeneration (GTR) to hydrogels and cell sheets and using 3D printing, a scaffold with an elaborate biomimetic structure can be constructed to guide the orientation of fibers. The incorporation of cells and biotic factors improves regeneration. Nevertheless, the current studies lack long-term effect tracking, clinical research, and in-depth mechanistic research. In summary, periodontal tissue engineering still has considerable room for development. The development of materials and techniques and an in-depth study of the mechanism will provide an impetus for periodontal regeneration.

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Quin¯ones, Carlos R., and Raul G. Caffesse. "Current status of guided periodontal tissue regeneration." Periodontology 2000 9, no. 1 (October 1995): 55–68. http://dx.doi.org/10.1111/j.1600-0757.1995.tb00056.x.

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Munjal, Neha, Shalini Kapoor, Amit Bhardwaj, Gaurav Thakur, and Preeti Karhana. "Regeneration Therapy in Furcation Defect." Journal of Evolution of Medical and Dental Sciences 10, no. 15 (April 12, 2021): 1091–94. http://dx.doi.org/10.14260/jemds/2021/233.

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One of the main objectives of periodontal therapy is to regenerate tissues lost as a result of periodontal disease.1 Regeneration is the growth and differentiation of the new cells and intercellular substances to form its precursor or regeneration occurs through same type of tissue that has been destroyed from same type of precursor. It is a continuous-physiological phenomenon of new cells along with tissues which are constantly formed and manifested by mitotic activity in epithelium and connective tissue, new bone formation, and continuous cementum deposition. Histological and clinical studies have reported the potential of guided tissue regeneration (GTR) to regenerate alveolar bone, cementum and the periodontal ligament.2,3 The furcation area represents a unique periodontal site with specific anatomic and pathogenic characteristics and with important clinical and therapeutic implications. The progression of chronic inflammation during periodontitis may affect the bifurcation or trifurcation of multirooted teeth. Furcation morphology may restrict access for adequate debridement and root instrumentation and may have a reduced source of available cells and blood supply from the periodontal ligament and bone defect. One important factor for successful regeneration at furcation and nonfurcation sites is the amount of periodontium that remains apical and lateral to the defect. Coronal migration of cells originating from the periodontal ligament and bone marrow spaces is particularly critical to the healing outcome following periodontal regenerative procedures in furcation defects.

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Huang, Qiuxia, Xin Huang, and Lisha Gu. "Periodontal Bifunctional Biomaterials: Progress and Perspectives." Materials 14, no. 24 (December 10, 2021): 7588. http://dx.doi.org/10.3390/ma14247588.

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Periodontitis is a chronic infectious disease that destroys periodontal supportive tissues and eventually causes tooth loss. It is attributed to microbial and immune factors. The goal of periodontal therapy is to achieve complete alveolar bone regeneration while keeping inflammation well-controlled. To reach this goal, many single or composite biomaterials that produce antibacterial and osteogenic effects on periodontal tissues have been developed, which are called bifunctional biomaterials. In this review, we summarize recent progress in periodontal bifunctional biomaterials including bioactive agents, guided tissue regeneration/guided bone regeneration (GTR/GBR) membranes, tissue engineering scaffolds and drug delivery systems and provide novel perspectives. In conclusion, composite biomaterials have been greatly developed and they should be chosen with care due to the risk of selection bias and the lack of evaluation of the validity of the included studies.

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SUZUKI, Akio, Shinya YAMAGUCHI, and Miyoko MATSUE. "Periodontal Regeneration in Experimental Periodontal Wound Model with Membranes for Guided Tissue Regeneration." Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 33, no. 3 (1991): 479–91. http://dx.doi.org/10.2329/perio.33.479.

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Iviglia, Giorgio, Saeid Kargozar, and Francesco Baino. "Biomaterials, Current Strategies, and Novel Nano-Technological Approaches for Periodontal Regeneration." Journal of Functional Biomaterials 10, no. 1 (January 2, 2019): 3. http://dx.doi.org/10.3390/jfb10010003.

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Periodontal diseases involve injuries to the supporting structures of the tooth and, if left untreated, can lead to the loss of the tooth. Regenerative periodontal therapies aim, ideally, at healing all the damaged periodontal tissues and represent a significant clinical and societal challenge for the current ageing population. This review provides a picture of the currently-used biomaterials for periodontal regeneration, including natural and synthetic polymers, bioceramics (e.g., calcium phosphates and bioactive glasses), and composites. Bioactive materials aim at promoting the regeneration of new healthy tissue. Polymers are often used as barrier materials in guided tissue regeneration strategies and are suitable both to exclude epithelial down-growth and to allow periodontal ligament and alveolar bone cells to repopulate the defect. The problems related to the barrier postoperative collapse can be solved by using a combination of polymeric membranes and grafting materials. Advantages and drawbacks associated with the incorporation of growth factors and nanomaterials in periodontal scaffolds are also discussed, along with the development of multifunctional and multilayer implants. Tissue-engineering strategies based on functionally-graded scaffolds are expected to play an ever-increasing role in the management of periodontal defects.

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Mombelli, Andrea, Niklaus P. Lang, and Sture Nyman. "Isolation of Periodontal Species After Guided Tissue Regeneration." Journal of Periodontology 64, no. 11s (November 1993): 1171–75. http://dx.doi.org/10.1902/jop.1993.64.11s.1171.

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Campos, A. "Electron microprobe analysis in periodontal guided tissue regeneration." Cell Biology International 17, no. 7 (July 1993): 695–96. http://dx.doi.org/10.1006/cbir.1993.1124.

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Meseli, Suleyman Emre, Omer Birkan Agrali, Onder Peker, and Leyla Kuru. "Treatment of lateral periodontal cyst with guided tissue regeneration." European Journal of Dentistry 08, no. 03 (July 2014): 419–23. http://dx.doi.org/10.4103/1305-7456.137661.

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ABSTRACTLateral periodontal cyst (LPC), originated from epithelial rests in the periodontal ligament, is a noninflammatory cyst on the lateral surface of the root of a vital tooth. LPC is generally asymptomatic and presents a round or oval uniform lucency with well-defined borders radiographically. In this case report, clinical, histological and radiographical findings and periodontal treatment of 32-year-old female patient, who was referred to Department of Periodontology Clinic of Faculty of Dentistry, Marmara University with a painless hyperplastic lesion on the distobuccal site of the tooth number 12, were presented. The tooth number 12 was vital and a well-defined round radiolucent area with corticated borders was determined radiographically. Preliminary diagnosis was LPC based on clinical and radiographical findings. Mechanical periodontal treatment consisted of oral hygiene instructions, scaling and root planing was applied and flap operation was performed to gain access to the lesion. Following enucleation of the lesion, alveolar bone destruction shaped as a tunnel from labial to palatinal site was observed. The bone cavity was grafted with bovine-derived xenograft, followed by placement of a resorbable collagen membrane. Tissues removed from of the lesion were examined histologically. Hematoxylen-eosin stained sections showed vasculature granulomatous structure underlying squamous epithelium, and destructed bone spaces, all of which were consisted with LPC. Acceptable clinical healing was achieved at 6 months follow-up period. Satisfactory clinical and radiographical outcome can be achieved in the treatment of LPC using regenerative periodontal approach.

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Sun, Jiayue, Yinghan Hu, Yinxin Fu, Derong Zou, Jiayu Lu, and Chengqi Lyu. "Emerging roles of platelet concentrates and platelet-derived extracellular vesicles in regenerative periodontology and implant dentistry." APL Bioengineering 6, no. 3 (September 1, 2022): 031503. http://dx.doi.org/10.1063/5.0099872.

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Platelet concentrates (PCs) are easily obtained from autogenous whole blood after centrifugation and have evolved through three generations of development to include platelet-rich plasma, platelet-rich fibrin, and concentrated growth factor. Currently, PCs are widely used for sinus floor elevation, alveolar ridge preservation, periodontal bone defects, guided bone regeneration, and treatment of gingival recession. More recently, PCs have been leveraged for tissue regeneration to promote oral soft and hard tissue regeneration in implant dentistry and regenerative periodontology. PCs are ideal for this purpose because they have a high concentration of platelets, growth factors, and cytokines. Platelets have been shown to release extracellular vesicles (P-EVs), which are thought to be essential for PC-induced tissue regeneration. This study reviewed the clinical application of PCs and P-EVs for implant surgery and periodontal tissue regeneration.

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Anuroopa, P., S. Savita, and Navnita Singh. "Revitalization of periodontally Compromised Tooth using Platelet-rich Fibrin." Journal of Health Sciences & Research 7, no. 2 (2016): 63–66. http://dx.doi.org/10.5005/jp-journals-10042-1037.

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ABSTRACT The primary objective of periodontal therapy is to gain access to the diseased sites, achieving reduction in pocket depth, arresting further disease progression, and finally restoring the periodontal tissues lost due to disease process. This can be achieved with the help of bone grafts and guided tissue regeneration. In recent times, the use of growth factors in different forms has been advocated to regulate various cell-stromal interactions in periodontal regeneration. Platelet-rich fibrin (PRF), a rich source of autologous growth factors and cytokines, is an upcoming therapeutic approach in the management of periodontal osseous defects. Platelet-rich fibrin along with the commercially available bone grafts provides a potential for enhanced bone and soft tissue regeneration. This case report focuses on saving a mandibular anterior tooth with poor prognosis using PRF and alloplast bone graft to meet with the esthetic demand of patients. How to cite this article Singh N, Anuroopa P, Savita S. Revitalization of periodontally Compromised Tooth using Platelet-rich Fibrin. J Health Sci Res 2016;7(2):63-66.

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Alizadeh Tabari, Zahra, Hamed Homayouni, Tahere Pourseyediyan, Armita Arvin, Derrick Eiland, and Nima Moradi Majd. "Treatment of a Developmental Groove and Supernumerary Root Using Guided Tissue Regeneration Technique." Case Reports in Dentistry 2016 (2016): 1–5. http://dx.doi.org/10.1155/2016/2738569.

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Introduction. The radicular groove is a developmental groove which is usually found on the palatal or lateral aspects of the maxillary incisor teeth. The present case is a maxillary lateral incisor with a small second root and a deep radicular groove. The developmental groove caused a combined periodontal-endodontic lesion. Methods. Case was managed using a combined treatment procedure involving nonsurgical root canal therapy and surgical periodontal treatment. After completion of root canal treatment, guided tissue regeneration (GTR) was carried out using decalcified freeze dried bone allograft (DFDBA) and a bioabsorbable collagenous membrane. Tooth also was splinted for two months. Results. After 12 months the tooth was asymptomatic. The periapical radiolucency disappeared and probing depth did not exceed 3 mm. Conclusion. Combined treatment procedure involving nonsurgical root canal therapy and surgical periodontal regenerative treatment can be a predictable technique in treating combined endodontic-periodontal lesions caused by radicular groove.

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Funakoshi, Eiji. "The application of guided tissue regeneration, guided bone regeneration and implants to periodontal treatment." Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 40, Supplement1 (1998): 55. http://dx.doi.org/10.2329/perio.40.supplement1_55.

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Mancini, Leonardo, Mario Romandini, Adriano Fratini, Lorenzo Maria Americo, Saurav Panda, and Enrico Marchetti. "Biomaterials for Periodontal and Peri-Implant Regeneration." Materials 14, no. 12 (June 15, 2021): 3319. http://dx.doi.org/10.3390/ma14123319.

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Periodontal and peri-implant regeneration is the technique that aims to restore the damaged tissue around teeth and implants. They are surrounded by a different apparatus, and according to it, the regenerative procedure can differ for both sites. During the last century, several biomaterials and biological mediators were proposed to achieve a complete restoration of the damaged tissues with less invasiveness and a tailored approach. Based on relevant systematic reviews and articles searched on PubMed, Scopus, and Cochrane databases, data regarding different biomaterials were extracted and summarized. Bone grafts of different origin, membranes for guided tissue regeneration, growth factors, and stem cells are currently the foundation of the routinary clinical practice. Moreover, a tailored approach, according to the patient and specific to the involved tooth or implant, is mandatory to achieve a better result and a reduction in patient morbidity and discomfort. The aim of this review is to summarize clinical findings and future developments regarding grafts, membranes, molecules, and emerging therapies. In conclusion, tissue engineering is constantly evolving; moreover, a tailor-made approach for each patient is essential to obtain a reliable result and the combination of several biomaterials is the elective choice in several conditions.

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Jovicic, Bojan, Zoran Lazic, and Milica Nedic. "Therapeutic efficacy of guided tissue regeneration and connective tissue autotransplants with periosteum in the management of gingival recession." Vojnosanitetski pregled 65, no. 10 (2008): 758–62. http://dx.doi.org/10.2298/vsp0810758j.

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Background/Aim. Gingival recession progression in clinical practice as an ethiological factor of periodontal diseases, and symptoms of the disease have caused the development of various surgical procedures and techniques of the reconstruction of periodontal defects. The aim of this study was to verify efficacy of surgical procedures that include connective tissue autotransplants with periosteum and guided tissue regeneration for the treatment of gingival recession. Methods. The study included 20 teet with gingival recession, M?ller class II and III. Ten teeth with gingival recession were treated with resorptive membrane and coronary guided surgical flap (GTR group). On the contralateral side 10 teeth with gingival recession were treated with connective tissue autotransplants with periosteum in combination with coronary guided surgical flap (TVT group). We measured the degree of epithelial attachment (DEA), width of subgingival curettage (WGC) and vertical deepness of recession (VDR). For statistical significance we used Student's ttest. Results. The study revealed statistical significance in reducing VDR by both used treatments. Root deepness in GTR and TVT group was 63.5%, and 90%, respectively. With both surgical techniques we achieved coronary dislocation of the epithelial attachment, larger zone of gingival curettage, and better oral hygiene. Conclusion. Current surgical techniques are effective in the regeneration of deep periodontal spaces and the treatment of gingival recession. Significantly better results were achieved with the used coronary guided surgical flap than with guided tissue regeneration.

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Sufaru, Irina-Georgeta, Georgiana Macovei, Simona Stoleriu, Maria-Alexandra Martu, Ionut Luchian, Diana-Cristala Kappenberg-Nitescu, and Sorina Mihaela Solomon. "3D Printed and Bioprinted Membranes and Scaffolds for the Periodontal Tissue Regeneration: A Narrative Review." Membranes 12, no. 9 (September 19, 2022): 902. http://dx.doi.org/10.3390/membranes12090902.

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Numerous technologies and materials were developed with the aim of repairing and reconstructing the tissue loss in patients with periodontitis. Periodontal guided bone regeneration (GBR) and guided tissue regeneration (GTR) involves the use of a membrane which prevents epithelial cell migration, and helps to maintain the space, creating a protected area in which tissue regeneration is favored. Over the time, manufacturing procedures of such barrier membranes followed important improvements. Three-dimensional (3D) printing technology has led to major innovations in periodontal regeneration methods, using technologies such as inkjet printing, light-assisted 3D printing or micro-extrusion. Besides the 3D printing of monophasic and multi-phasic scaffolds, bioprinting and tissue engineering have emerged as innovative technologies which can change the way we see GTR and GBR.

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Caton, Jack G. "Periodontal Wound Healing with Biodegradable Guided Tissue Regeneration Barriers." Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 37, Supplement1 (1995): 31. http://dx.doi.org/10.2329/perio.37.supplement1_31.

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Onizuka, Satoru, and Takanori Iwata. "Application of Periodontal Ligament-Derived Multipotent Mesenchymal Stromal Cell Sheets for Periodontal Regeneration." International Journal of Molecular Sciences 20, no. 11 (June 7, 2019): 2796. http://dx.doi.org/10.3390/ijms20112796.

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Periodontitis is a chronic inflammatory disorder that causes destruction of the periodontal attachment apparatus including alveolar bone, the periodontal ligament, and cementum. Dental implants have been routinely installed after extraction of periodontitis-affected teeth; however, recent studies have indicated that many dental implants are affected by peri-implantitis, which progresses rapidly because of the failure of the immune system. Therefore, there is a renewed focus on periodontal regeneration aroundnatural teeth. To regenerate periodontal tissue, many researchers and clinicians have attempted to perform periodontal regenerative therapy using materials such as bioresorbable scaffolds, growth factors, and cells. The concept of guided tissue regeneration, by which endogenous periodontal ligament- and alveolar bone-derived cells are preferentially proliferated by barrier membranes, has proved effective, and various kinds of membranes are now commercially available. Clinical studies have shown the significance of barrier membranes for periodontal regeneration; however, the technique is indicated only for relatively small infrabony defects. Cytokine therapies have also been introduced to promote periodontal regeneration, but the indications are also for small size defects. To overcome this limitation, ex vivo expanded multipotent mesenchymal stromal cells (MSCs) have been studied. In particular, periodontal ligament-derived multipotent mesenchymal stromal cells are thought to be a responsible cell source, based on both translational and clinical studies. In this review, responsible cell sources for periodontal regeneration and their clinical applications are summarized. In addition, recent transplantation strategies and perspectives about the cytotherapeutic use of stem cells for periodontal regeneration are discussed.

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Abu-Ta'a, Mahmoud. "Adjunctive Systemic Antimicrobial Therapy vs Asepsis in Conjunction with Guided Tissue Regeneration: A Randomized, Controlled Clinical Trial." Journal of Contemporary Dental Practice 17, no. 1 (January 2016): 3–6. http://dx.doi.org/10.5005/jp-journals-10024-1794.

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ABSTRACT Aim This randomized clinical trial compares the usefulness of adjunctive antibiotics, while strict asepsis was followed during periodontal surgery involving guided tissue regeneration. Materials and methods Two groups of 20 consecutive patients each with advanced periodontal disease were randomly assigned to treatment. They displayed one angular defect each with an intrabony component ≥3 mm, probing pocket depth and probing attachment level (PAL) ≥7 mm. Test group included 13 males, mean age 60 years, treated with enamel matrix derivative (EMD) and demineralized freeze-dried bone allograft with modified papilla preservation technique, received oral amoxicillin 1 gm, 1 hour preoperatively and 2 gm for 2 days postoperatively. Control group included 10 males, mean age 57 years, treated with EMD and demineralized freeze-dried bone allograft with modified papilla preservation technique, received no antibiotics. Outcome measures were clinical attachment level (CAL) gain, residual periodontal pocket depth (res. PD), gingival recession (GR), bleeding on probing (BOP), adverse events and postoperative complications. Patients were followed up to 12 months after periodontal surgery involving guided tissue regeneration. Results There were no significant differences between both groups for CAL gain, res. PD, GR, BOP nor other clinical parameters, though patients’ subjective perception of postoperative discomfort was significantly smaller in the group receiving antibiotics. Conclusion Antibiotics do not provide significant advantages concerning clinical periodontal parameters nor concerning postoperative infections in case of proper asepsis. It does, on the contrary, reduce postoperative discomfort. Clinical significance Regarding the results of this study, adjunctive systemic antibiotics in combination with guided tissue regeneration may be useful in reducing postoperative discomfort but may not be helpful for improving periodontal regeneration outcomes. How to cite this article Abu-Ta'a M. Adjunctive Systemic Antimicrobial Therapy vs Asepsis in Conjunction with Guided Tissue Regeneration: A Randomized, Controlled Clinical Trial. J Contemp Dent Pract 2016;17(1):3-6.

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Reçica, Bylbyl, Mirjana Popovska, Amella Cana, Lindita Zendeli Bedxeti, Urim Tefiku, Spiro Spasovski, Ana Spasovska-Gjorgovska, Teuta Kutllovci, and Jehona F. Ahmedi. "Use of Biomaterials for Periodontal Regeneration: A Review." Open Access Macedonian Journal of Medical Sciences 8, F (April 20, 2020): 90–97. http://dx.doi.org/10.3889/oamjms.2020.4354.

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BACKGROUND: Management of bone periodontal defects, destruction, and loss of the alveolar bone is considered a challenge for modern periodontal regeneration and implant dentistry. Numerous of biomaterials are being used in periodontal regenerative treatment. AIM: This study aims to know the characteristics of biomaterials and their efficiency in periodontal surgical treatment as regenerative therapy. METHODS: A systematic review of the literature considering reviews, clinical studies, original papers, and articles from electronic data has been used. RESULTS: Different biomaterials such as Straumann® Emdogain®, Geistlich Bio-Oss®, MIS 4MATRIX – Bone Graft, Platelet-rich fibrin (PRF), Mis Bone-4MATRIX, and PRF are being used for periodontal regeneration treatment, hence revealing more effective outcomes when combined. PRP together with conventional grafting procedures may be a beneficial treatment approach, guided tissue regeneration with bioabsorbable membranes in combination with Bio-Oss are stable on a long-term basis. CONCLUSION: Biomaterials being used in periodontal surgical treatment have the different regenerative ability. The combined use of biomaterials might result in a better clinical outcome. There are also a number of other biomaterials used to treat periodontal regeneration, but generally all have the same ability and the same molecular structure as highlighted in this literature review.

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Daldry, Michael, Jaini Shah, Ewen McColl, and Rob Witton. "Enamel Matrix Derivative Use in Dentistry: An Update." Dental Update 49, no. 4 (April 2, 2022): 301–6. http://dx.doi.org/10.12968/denu.2022.49.4.301.

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Following a review of periodontal wound healing, this article discusses techniques designed to optimise periodontal wound healing, including guided-tissue regeneration and periodontal regeneration using enamel matrix derivatives. Enamel matrix derivatives are porcine derived, and are thought to stimulate differentiation, proliferation, migration and mineralization in cells found in periodontal tissues. This article charts the development in surgical techniques to optimise outcomes from regenerative techniques, in addition to explaining complications and how they can be avoided. Recent research relating to use of enamel matrix derivatives as an adjunct to non-surgical periodontal therapy is described, and while the evidence is limited to a single research study, the present article discusses the potential use of this technique in practice, accepting that a cost–benefit analysis would be required for individual patients. CPD/Clinical Relevance: An update for practitioners on developments in use of enamel matrix derivatives in dentistry to allow informed decision-making on the utility and value of using flapless techniques.

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Pouroutzidou, Georgia K., Maria Lazaridou, Chrysanthi Papoulia, Ioannis Tsamesidis, Konstantinos Chrissafis, George Vourlias, Konstantinos M. Paraskevopoulos, Dimitrios Bikiaris, and Eleana Kontonasaki. "Electrospun PLGA Membranes with Incorporated Moxifloxacin-Loaded Silica-Based Mesoporous Nanocarriers for Periodontal Regeneration." Nanomaterials 12, no. 5 (March 2, 2022): 850. http://dx.doi.org/10.3390/nano12050850.

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Engineered electrospun membranes have emerged as promising materials in guided tissue regeneration, as they provide an appropriate framework for the formation of new functional periodontal tissues. The development of multifunctional local drug delivery systems with sustained release of drugs for prolonged infection control can be used in periodontal surgical interventions to simultaneously prohibit epithelium downgrowth and ensure proper healing and regeneration of damaged periodontal tissues. The aim of the present study was the fabrication of novel composite membranes from PLGA/moxifloxacin-loaded mesoporous nanocarriers through electrospinning and the evaluation of their drug release profiles. The addition of moxifloxacin-loaded mesoporous nanocarriers in PLGA yielded a sustained and prolonged drug release, while maintaining satisfactory mechanical strength. The freshly fabricated membranes were found to be biocompatible at masses less than 1 mg after exposure to healthy erythrocytes. Increase in the amount of polymer led to more uniform fibers with large diameters and pores. The study of the parameters of the electrospinning process indicated that increase in the applied voltage value and rotation speed of the collector led to more uniform fibers with higher diameter and larger pores, suitable for tissue regeneration applications, such as periodontal tissue regeneration.

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Elangovan, Ramnath, Ramakrishnan Theyagarajan, Mejalla Muthiah Amala Dhas, and Vidya Sekhar. "Hopelessness..? Turned Hopefullness..! – Salvaging A Molar with A Mother’s Touch– Case Report." Journal of Dentists 7 (March 8, 2019): 17–21. http://dx.doi.org/10.12974/2311-8695.2019.07.3.

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Periodontitis is the inflammatory disease that leads to destruction of the supporting structures of the teeth. The early diagnosis and treatment of periodontitis is always not possible as the periodontitis progress with minimal or no pain. Regenerative medicine is the field that uses exogenous or endogenous stem cells for the regeneration of the lost periodontal tissues. This case report presents about salvaging a molar which was of poor prognosis and at the verge of extraction using Amniotic Membrane as a barrier membrane in the procedure of Guided Tissue Regeneration.

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Lee, Hwa-Sun, Soo-Hwan Byun, Seoung-Won Cho, and Byoung-Eun Yang. "Past, Present, and Future of Regeneration Therapy in Oral and Periodontal Tissue: A Review." Applied Sciences 9, no. 6 (March 13, 2019): 1046. http://dx.doi.org/10.3390/app9061046.

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Chronic periodontitis is the most common disease which induces oral tissue destruction. The goal of periodontal treatment is to reduce inflammation and regenerate the defects. As the structure of periodontium is composed of four types of different tissue (cementum, alveolar bone periodontal ligament, and gingiva), the regeneration should allow different cell proliferation in the separated spaces. Guided tissue regeneration (GTR) and guided bone regeneration (GBR) were introduced to prevent epithelial growth into the alveolar bone space. In the past, non-absorbable membranes with basic functions such as space maintenance were used with bone graft materials. Due to several limitations of the non-absorbable membranes, membranes of the second and third generation equipped with controlled absorbability, and a functional layer releasing growth factors or antimicrobials were introduced. Moreover, tissue engineering using biomaterials enabled faster and more stable tissue regeneration. The scaffold with three-dimensional structures manufactured by computer-aided design and manufacturing (CAD/CAM) showed high biocompatibility, and promoted cell infiltration and revascularization. In the future, using the cell sheath, pre-vascularizing and bioprinting techniques will be applied to the membrane to mimic the original tissue itself. The aim of the review was not only to understand the past and the present trends of GTR and GBR, but also to be used as a guide for a proper future of regeneration therapy in the oral region.

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Urban, Istvan, Nicholas Caplanis, and Jaime L. Lozada. "Simultaneous Vertical Guided Bone Regeneration and Guided Tissue Regeneration in the Posterior Maxilla Using Recombinant Human Platelet-Derived Growth Factor: A Case Report." Journal of Oral Implantology 35, no. 5 (October 1, 2009): 251–56. http://dx.doi.org/10.1563/aaid-joi-d-09-00004.1.

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Abstract This clinical case report describes and demonstrates successful use of recombinant human platelet-derived growth factor (rhPDGF-BB) in conjunction with autogenous bone, anorganic bone mineral, and barrier membranes to reconstruct severe alveolar bone defects. A combined sinus augmentation and vertical alveolar ridge augmentation was successfully performed. In addition, a significant amount of periodontal bone gain was achieved in close apposition to a previously denuded root surface, which is significant from a periodontal standpoint, given the possibility of vertical periodontal regeneration.

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Novaes Jr, Arthur Belém, Daniela Bazan Palioto, Patrícia Freitas de Andrade, and Julie Teresa Marchesan. "Regeneration of class II furcation defects: determinants of increased success." Brazilian Dental Journal 16, no. 2 (August 2005): 87–97. http://dx.doi.org/10.1590/s0103-64402005000200001.

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One of the most important indications for guided tissue regeneration (GTR) treatment is class II furcation lesion. However, periodontal regeneration of this type of defect, although possible, is not considered totally predictable, especially in terms of complete bone fill. Many factors may account for variability in the response to regenerative therapy in class II furcation. The purpose of this review is to assess the prognostic significance of factors related to the patient (smoking, stress, diabetes mellitus, acquired immunodeficiency syndrome and other acute and debilitating diseases, and the presence of multiple deep periodontal pockets), local factors (furcal anatomy, defect morphology, thickness of gingival tissue and tooth mobility), surgical treatment (infection control, bone replacement grafts combined with barriers or GTR alone, type of barrier and surgical technique), and postoperative period (plaque control, membrane exposure, membrane retrieval and a regular supportive periodontal care program) for successful of GTR in class II furcations.

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Nygaard-ostby, Per, Georg Tellefsen, Thorarinn J. Sigurdsson, Grenith J. Zimmerman, and Ulf M. E. Wikesjo. "Periodontal healing following reconstructive surgery: effect of guided tissue regeneration." Journal of Clinical Periodontology 23, no. 12 (December 1996): 1073–79. http://dx.doi.org/10.1111/j.1600-051x.1996.tb01806.x.

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Lafzi, Ardeshir, Ramin Mostofi Zadeh Farahani, Mohammadali M. Shoja, and R. Shane Tubbs. "Amniotic membrane: A potential candidate for periodontal guided tissue regeneration?" Medical Hypotheses 69, no. 2 (January 2007): 454. http://dx.doi.org/10.1016/j.mehy.2006.12.022.

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Jaykumar, Gade, Gade Vandana, and Karemore Vaibhav. "Guided tissue regeneration in endodontic – periodontal lesion: A case report." Journal of Pierre Fauchard Academy (India Section) 25, no. 1 (January 2011): 41–44. http://dx.doi.org/10.1016/s0970-2199(11)51007-0.

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Sun, Maolei, Yun Liu, Kun Jiao, Wenyuan Jia, Kongzhao Jiang, Zhiqiang Cheng, Guomin Liu, and Yungang Luo. "A periodontal tissue regeneration strategy via biphasic release of zeolitic imidazolate framework-8 and FK506 using a uniaxial electrospun Janus nanofiber." Journal of Materials Chemistry B 10, no. 5 (2022): 765–78. http://dx.doi.org/10.1039/d1tb02174e.

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Namanloo, Reza Abdollahi, Maedeh Ommani, Kamyar Abbasi, Mostafa Alam, Ashkan Badkoobeh, Mahdi Rahbar, Hadi Kokabi Arasteh, Emran Hajmohammadi, Reza Sayyad Soufdoost, and Seyed Ali Mosaddad. "Biomaterials in Guided Bone and Tissue Regenerations: An Update." Advances in Materials Science and Engineering 2022 (May 5, 2022): 1–14. http://dx.doi.org/10.1155/2022/2489399.

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Purpose. Guided tissue reconstruction can be performed to restore the supporting structure of a previously lost tooth, which, in addition to maintaining beauty, preserves the function of the tooth in the patient. Materials and Methods. In this review, Scopus, PubMed, and MEDLINE databases were searched using the keywords “biocompatible materials,” “membrane,” “bone regeneration,” “tissue reconstruction,” and “dental biomaterials.” Overall, 150 articles were reviewed, and finally, 107 articles published during 2000–2021 were included in the final paper. Results. Studies have been conducted on a variety of membranes in both clinical and experimental settings. The first half of this article explores the different kinds of membranes and diverse classes of biomaterials used in these procedures. Secondly, biomaterials are examined for their therapeutic uses such as growth factors, stem cells, and gene delivery vehicles. Conclusion. If a tooth has been extracted or if the gums have been infected with periodontal disease, guided bone regeneration procedures may be used to restore the lost bone. Recent years have seen a variety of approaches to regenerating these tissues. To prevent nonossifying cells from entering, membranes are heavily employed during guided rebuilding.

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Wang, Chen-Ying, Yung-Cheng Chiu, Alvin Kai-Xing Lee, Yun-An Lin, Ping-Yi Lin, and Ming-You Shie. "Biofabrication of Gingival Fibroblast Cell-Laden Collagen/Strontium-Doped Calcium Silicate 3D-Printed Bi-Layered Scaffold for Osteoporotic Periodontal Regeneration." Biomedicines 9, no. 4 (April 16, 2021): 431. http://dx.doi.org/10.3390/biomedicines9040431.

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Periodontal disease is a chronic disease that can lead to lose teeth and even tooth loss if left untreated. Osteoporosis and periodontal disease share similar characteristics and associated factors. Current regenerative techniques for periodontal diseases are ineffective in restoring complete function and structural integrity of periodontium due to unwanted migration of cells. In this study, we applied the concept of guided tissue regeneration (GTR) and 3D fabricated gingival fibroblast cell-laden collagen/strontium-doped calcium silicate (SrCS) bi-layer scaffold for periodontal regeneration. The results revealed that the bioactive SrCS had a hydroxyapatite formation on its surface after 14 days of immersion and that SrCS could release Sr and Si ions even after 6 months of immersion. In addition, in vitro results showed that the bi-layer scaffold enhanced secretion of FGF-2, BMP-2, and VEGF from human gingival fibroblasts and increased secretion of osteogenic-related proteins ALP, BSP, and OC from WJMSCs. In vivo studies using animal osteoporotic models showed that the 3D-printed cell-laden collagen/SrCS bi-layer scaffold was able to enhance osteoporotic bone regeneration, as seen from the increased Tb.Th and BV/TV ratio and the histological stains. In conclusion, it can be seen that the bi-layer scaffolds enhanced osteogenesis and further showed that guided periodontal regeneration could be achieved using collagen/SrCS scaffolds, thus making it a potential candidate for future clinical applications.

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Higuchi, Fortunato, Woźniak, Chodara, Domaschke, Męczyńska-Wielgosz, Kruszewski, Dommann, and Łojkowski. "Polymer Membranes Sonocoated and Electrosprayed with Nano-Hydroxyapatite for Periodontal Tissues Regeneration." Nanomaterials 9, no. 11 (November 15, 2019): 1625. http://dx.doi.org/10.3390/nano9111625.

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Diseases of periodontal tissues are a considerable clinical problem, connected with inflammatory processes and bone loss. The healing process often requires reconstruction of lost bone in the periodontal area. For that purpose, various membranes are used to prevent ingrowth of epithelium in the tissue defect and enhance bone regeneration. Currently-used membranes are mainly non-resorbable or are derived from animal tissues. Thus, there is an urgent need for non-animal-derived bioresorbable membranes with tuned resorption rates and porosity optimized for the circulation of body nutrients. We demonstrate membranes produced by the electrospinning of biodegradable polymers (PDLLA/PLGA) coated with nanohydroxyapatite (nHA). The nHA coating was made using two methods: sonocoating and electrospraying of nHA suspensions. In a simulated degradation study, for electrosprayed membranes, short-term calcium release was observed, followed by hydrolytic degradation. Sonocoating produced a well-adhering nHA layer with full coverage of the fibers. The layer slowed the polymer degradation and increased the membrane wettability. Due to gradual release of calcium ions the degradation-associated acidity of the polymer was neutralized. The sonocoated membranes exhibited good cellular metabolic activity responses against MG-63 and BJ cells. The collected results suggest their potential use in Guided Tissue Regeneration (GTR) and Guided Bone Regeneration (GBR) periodontal procedures.

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Mellonig, James T. "Autogenous and Allogeneic Bone Grafts in Periodontal Therapy." Critical Reviews in Oral Biology & Medicine 3, no. 4 (July 1992): 333–52. http://dx.doi.org/10.1177/10454411920030040201.

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This article is limited to a review of bone autografts and allografts, as used in periodontal therapy. The various graft materials are discussed with respect to case reports, controlled clinical trials, and human histology. Other reviewed areas are wound healing with periodontal bone grafts, tissue banking and freeze-dried bone allografts, and the use of bone grafts in guided tissue regeneration.

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Bousnaki, Maria, Anastasia Beketova, and Eleana Kontonasaki. "A Review of In Vivo and Clinical Studies Applying Scaffolds and Cell Sheet Technology for Periodontal Ligament Regeneration." Biomolecules 12, no. 3 (March 11, 2022): 435. http://dx.doi.org/10.3390/biom12030435.

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Different approaches to develop engineered scaffolds for periodontal tissues regeneration have been proposed. In this review, innovations in stem cell technology and scaffolds engineering focused primarily on Periodontal Ligament (PDL) regeneration are discussed and analyzed based on results from pre-clinical in vivo studies and clinical trials. Most of those developments include the use of polymeric materials with different patterning and surface nanotopography and printing of complex and sophisticated multiphasic composite scaffolds with different compartments to accomodate for the different periodontal tissues’ architecture. Despite the increased effort in producing these scaffolds and their undoubtable efficiency to guide and support tissue regeneration, appropriate source of cells is also needed to provide new tissue formation and various biological and mechanochemical cues from the Extraccellular Matrix (ECM) to provide biophysical stimuli for cell growth and differentiation. Cell sheet engineering is a novel promising technique that allows obtaining cells in a sheet format while preserving ECM components. The right combination of those factors has not been discovered yet and efforts are still needed to ameliorate regenerative outcomes towards the functional organisation of the developed tissues.

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Robert, Pierre M., and Robert M. Frank. "Periodontal Guided Tissue Regeneration With a New Resorbable Polylactic Acid Membrane." Journal of Periodontology 65, no. 5 (May 1994): 414–22. http://dx.doi.org/10.1902/jop.1994.65.5.414.

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Kuru, L., M. H. Parkar, G. S. Griffiths, and I. Olsen. "Flow Cytometry Analysis of Guided Tissue Regeneration-Associated Human Periodontal Cells." Journal of Periodontology 72, no. 8 (August 2001): 1016–24. http://dx.doi.org/10.1902/jop.2001.72.8.1016.

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Nowzari, Hessam, Fariborz Matian, and Jorgen Slots. "Periodontal pathogens on polytetrafluoroethylene membrane for guided tissue regeneration inhibit healing." Journal of Clinical Periodontology 22, no. 6 (June 1995): 469–74. http://dx.doi.org/10.1111/j.1600-051x.1995.tb00179.x.

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Oxford, Gregory E., George Quintero, Charles B. Stuller, and Marlin E. Gher. "Treatment of 3rd molar-induced periodontal defects with guided tissue regeneration." Journal of Clinical Periodontology 24, no. 7 (July 1997): 464–69. http://dx.doi.org/10.1111/j.1600-051x.1997.tb00213.x.

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Needleman, Ian, Richard Tucker, Elaine Giedrys - Leeper, and Helen Worthington. "Guided tissue regeneration for periodontal intrabony defects - a Cochrane Systematic Review*." Periodontology 2000 37, no. 1 (February 2005): 106–23. http://dx.doi.org/10.1111/j.1600-0757.2004.37101.x.

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Sela, Michael N., David Kohavi, Emanuela Krausz, Doron Steinberg, and Graciela Rosen. "Enzymatic degradation of collagen-guided tissue regeneration membranes by periodontal bacteria." Clinical Oral Implants Research 14, no. 3 (May 2003): 263–68. http://dx.doi.org/10.1034/j.1600-0501.2003.140302.x.

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Needleman, Ian, Richard Tucker, Elaine Giedrys-Leeper, and Helen Worthington. "A systematic review of guided tissue regeneration for periodontal infrabony defects." Journal of Periodontal Research 37, no. 5 (October 2002): 380–88. http://dx.doi.org/10.1034/j.1600-0765.2002.01369.x.

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Journal articles on the topic 'Periodontal Guided Tissue Regeneration'

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