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Journal articles on the topic 'Periodontal Ligament Cells'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Sena, K., Y. Morotome, O. Baba, T. Terashima, Y. Takano, and I. Ishikawa. "Gene Expression of Growth Differentiation Factors in the Developing Periodontium of Rat Molars." Journal of Dental Research 82, no. 3 (2003): 166–71. http://dx.doi.org/10.1177/154405910308200304.

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Growth and differentiation factors (GDF) 5, 6, and 7 are known to play roles in tendon and ligament formation, and are therefore probably involved in the formation of periodontal ligament. In this study, we sought to determine temporal and spatial expression of GDF-5, -6, and -7 mRNA in developing periodontal tissue of rat molars using in situ hybridization. GDF gene expression in the periodontal ligament was first detected in cells associated with the initial process of periodontal ligament fiber bundle formation. Gene signals were also detected in cells located along the alveolar bone and ce

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2

Saito, A., E. Saito, M. Kawanami, and A. Shimada. "Healing in Transplanted Teeth with Periodontal Ligament Cultured In Vitro." Cell Transplantation 12, no. 5 (2003): 519–25. http://dx.doi.org/10.3727/000000003108747082.

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Regeneration of connective tissue attachment is the ultimate goal of periodontal therapy. It has been suggested that periodontal ligament cells possess the potential to create new connective tissue attachment. However, as cells from gingiva and alveolar bone occupy the root surface during initial wound healing, population by periodontal ligament cells is limited in vivo. We have been developing a new periodontal regeneration technique using in vitro tissue culture of periodontal ligament remaining on a periodontally involved root. The purpose of this study was to examine the periodontal healin

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3

Kramer, P. R., S. Nares, S. F. Kramer, D. Grogan, and M. Kaiser. "Mesenchymal Stem Cells Acquire Characteristics of Cells in the Periodontal Ligament in vitro." Journal of Dental Research 83, no. 1 (2004): 27–34. http://dx.doi.org/10.1177/154405910408300106.

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Mesenchymal stem cells differentiate into multiple types of cells derived from mesenchyme. Periodontal ligament cells are primarily derived from mesenchyme; thus, we expected mesenchymal stem cells to differentiate into periodontal ligament. Using a combination of immunohistochemistry and in situ hybridization on co-cultures of mesenchymal stem cells and periodontal ligament, we observed a significant increase in mesenchymal stem cells’ expression of osteocalcin and osteopontin and a significant decrease in expression of bone sialoprotein, characteristics of periodontal ligament in vivo. Incre

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Aditya, Vangara, and Kharidhi Laxman Vandana. "Management of endo-perio lesion with autologous stem cell therapy." Saudi Journal of Oral Sciences 11, no. 1 (2024): 54–59. http://dx.doi.org/10.4103/sjoralsci.sjoralsci_79_23.

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The objective of periodontal therapy is the regeneration of tooth-supporting tissues. Various treatment modalities, such as the use of bone grafting materials, guided tissue regeneration, and delivery of enamel matrix derivatives or growth factors, are applied with large variability in regenerative outcomes. However, a case report was done by utilization of autologous dental pulp stem cells and periodontal ligament stem cell niches in the treatment of bone loss associated with endodontically and periodontally involved teeth. An autologous periodontal ligament stem cells niche adherent to the r

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5

Pinheiro, Gabriela Veloso Vieira da Silva, Robinson Sabino-Silva, Melissa Rodrigues de Araujo, et al. "Experimental Acute Sepsis Reduced Number of Osteocalcin Immunolabeled Cells in Periodontal Ligament." Brazilian Dental Journal 31, no. 2 (2020): 143–51. http://dx.doi.org/10.1590/0103-6440202003024.

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Abstract The aim of this study was to evaluate the effect of acute sepsis in the periodontal ligament, alveolar and furcation bone in absence of periodontitis induction through histological and immunohistochemical analyses. A septic rat model was established by cecal ligation and puncture (CLP). Twelve rats were randomly divided into CLP (n=6) and Sham (n=6) groups. The animals were euthanized at 24 h and hemimandibles were submitted to histomorfometric (bone matrix, collagenous fibers, fibroblasts, osteocytes, inflammatory cells, and blood vessels) and immunohistochemical (BMP-2/4, RANKL and

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6

Wang, Penglai, Wen Wang, Tengyu Geng, et al. "EphrinB2 regulates osteogenic differentiation of periodontal ligament stem cells and alveolar bone defect regeneration in beagles." Journal of Tissue Engineering 10 (January 2019): 204173141989436. http://dx.doi.org/10.1177/2041731419894361.

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EphrinB2, a membrane protein regulating bone homeostasis, has been demonstrated to induce osteogenic gene expression in periodontal ligament fibroblasts. The aim of this study was to explore the effects of ephrinB2 on osteogenic differentiation of periodontal ligament stem cells and on alveolar bone regeneration in vivo. We assessed the osteogenic gene expression and osteogenic differentiation potential of ephrinB2-modified human and canine periodontal ligament stem cells, in which ephrinB2 expression was upregulated via lentiviral vector transduction. EphrinB2-modified canine periodontal liga

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7

Seo, B. M., M. Miura, W. Sonoyama, C. Coppe, R. Stanyon, and S. Shi. "Recovery of Stem Cells from Cryopreserved Periodontal Ligament." Journal of Dental Research 84, no. 10 (2005): 907–12. http://dx.doi.org/10.1177/154405910508401007.

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Human post-natal stem cells possess a great potential to be utilized in stem-cell-mediated clinical therapies and tissue engineering. It is not known whether cryopreserved human tissues contain functional post-natal stem cells. In this study, we utilized human periodontal ligament to test the hypothesis that cryopreserved human periodontal ligament contains retrievable post-natal stem cells. These cryopreserved periodontal ligament stem cells maintained normal periodontal ligament stem cell characteristics, including expression of the mesenchymal stem cell surface molecule STRO-1, single-colon

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8

Garna, Devy, Manmeet Kaur, Francis J. Hughes, and Mandeep Ghuman. "Comparison of the Expression of Periodontal Markers in Dental and Bone Marrow-derived Mesenchymal Stem Cells." Open Dentistry Journal 14, no. 1 (2020): 196–202. http://dx.doi.org/10.2174/1874210602014010196.

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Background: Periodontal ligament stem cells are a source of mesenchymal stem cells, but it is unclear whether their phenotype is distinct from mesenchymal stem cells derived from different tissues, such as those derived from bone marrow. Objective: To investigate the expression of the putative PDL markers asporin, periostin, nestin and cementum protein 1, by periodontal ligament stem cells both constitutively and during osteogenic differentiation when compared to bone marrow-derived mesenchymal stem cells, and dental pulp stem cells. Methods: The primary human periodontal ligament, bone marrow

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9

Song, In Seok, Yoon Sic Han, Joo-Hee Lee, Soyoun Um, Hui Young Kim, and Byoung Moo Seo. "Periodontal Ligament Stem Cells for Periodontal Regeneration." Current Oral Health Reports 2, no. 4 (2015): 236–44. http://dx.doi.org/10.1007/s40496-015-0060-0.

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10

Lauer, Günter, and Byung Ho Choi. "The ultrastructure of the periodontal ligament cells-titanium interface with vitro." Malaysian Journal of Oral and Maxillofacial Surgery 1, no. 1 (2000): 11–16. https://doi.org/10.4103/mjoms_200011_11.

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Several studies have shown that a peridontal ligament can form on titanium dental implants which were placed in contact with the periodontal ligament of the retained roots. However, the following question is still critical: how do the periodontal ligament cells adhere to the implant surface? Little is known about the ultrastructure of the periodontal ligament cells-titanium interface. The objective of this study, therefore, was to gain insight into the morphology of the interface. Human periodontal ligament cells were cultured on thin titanium substrates obtained by electron beam evaporation o

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11

Gopinathan, Gokul, Xianghong Luan, and Thomas G. H. Diekwisch. "Epigenetic Repression of RUNX2 and OSX Promoters Controls the Nonmineralized State of the Periodontal Ligament." Genes 14, no. 1 (2023): 201. http://dx.doi.org/10.3390/genes14010201.

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The nonmineralized state of the mammalian periodontal ligament is one of the hallmarks of vertebrate evolution as it provides resilient and nontraumatic tooth anchorage for effective predation. Here we sought to determine how the chromatin state of key mineralization gene promoters contributes to the nonmineralized periodontal ligament in the midst of fully mineralized alveolar bone and cementum anchor tissues. In developing mouse periodontal tissues, RUNX2 was localized to alveolar bone–lining cells, while OSX was localized throughout the periodontal ligament’s soft tissue. Matching RT-PCR am

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12

Lund, Amy E. "PERIODONTAL LIGAMENT STEM CELLS ISOLATED." Journal of the American Dental Association 135, no. 9 (2004): 1236. http://dx.doi.org/10.14219/jada.archive.2004.0393.

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13

Komala, Devi, Muhammad Nurul Amin, and Yani Corvianindya Rahayu. "Uji Sitotoksisitas Hidroksiapatit Cangkang Telur Ayam Ras (Gallus gallus) terhadap Sel Fibroblas Ligamen Periodontal Manusia." STOMATOGNATIC - Jurnal Kedokteran Gigi 19, no. 1 (2022): 49. http://dx.doi.org/10.19184/stoma.v19i1.30702.

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Periodontitis is an inflammation disease of the periodontal tissues surrounding the teeth, include periodontal ligament fibroblast cell. The recently researches developed tissue engineering concept to accelerate regeneration and proliferation periodontal ligament cells. One of the major components of tissue engineering is scaffold. The hydroxyapatite is biomaterial that can be used as scaffold. The egg shell has the potential biowaste to be a source of hydroxyapatite biomaterial. Before being applied as a scaffold in the medical field, cytotoxicity testing needs to be done. This study aimed to

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14

Huang, Denghao, Jie Lei, Xingrui Li, Zhonghao Jiang, Maoxuan Luo, and Yao Xiao. "Erythropoietin Activates Autophagy to Regulate Apoptosis and Angiogenesis of Periodontal Ligament Stem Cells via the Akt/ERK1/2/BAD Signaling Pathway under Inflammatory Microenvironment." Stem Cells International 2022 (September 20, 2022): 1–24. http://dx.doi.org/10.1155/2022/9806887.

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Background. Angiogenic tissue engineering is a vital problem waiting to be settled for periodontal regeneration. Erythropoietin, a multieffect cytokine, has been reported as a protective factor for cell fate. According to our previous study, erythropoietin has a significantly angiogenic effect on periodontal ligament stem cells. To further explore its potential effects and mechanism, we studied biological behaviors of periodontal ligament stem cells under inflammatory microenvironment induced by different concentrations (0, 10, 20, 50, and 100 ng/mL) of tumor necrosis factor-α (TNF-α) and exam

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15

Hatakeyama, J., D. Philp, Y. Hatakeyama, et al. "Amelogenin-mediated Regulation of Osteoclastogenesis, and Periodontal Cell Proliferation and Migration." Journal of Dental Research 85, no. 2 (2006): 144–49. http://dx.doi.org/10.1177/154405910608500206.

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We previously reported that amelogenin isoforms M180 and leucine-rich amelogenin peptide (LRAP) are expressed in the periodontal region, and that their absence is associated with increased cementum defects in amelogenin-knockout (KO) mice. The aim of the present study was to characterize the functions of these isoforms in osteoclastogenesis and in the proliferation and migration of cementoblast/periodontal ligament cells. The co-cultures of wild-type (WT) osteoclast progenitor and KO cementoblast/periodontal ligament cells displayed more tartrate-resistant acid phosphatase (TRAP)-positive cell

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16

Dr., Yadav Chakravarthy, and G. Vinay Kumar Chowdary Dr. "QUANTITATIVE AND QUALITATIVE MINERALIZATION EVALUATION OF DENTAL PULPAL AND PERIODONTAL LIGAMENT STEM CELLS USING OSTEOIMAGE ASSAY – AN IN VITRO COMPARITIVE STUDY." International Journal of Applied and Advanced Scientific Research (IJAASR) 5, no. 1 (2020): 24–31. https://doi.org/10.5281/zenodo.3884134.

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The aim of this study is to evaluate the qualitative and quantitative mineralization ability of dental pulp and periodontal ligament stem cells using osteoimage assay. Comparing the quantitative and qualitative ability of dental pulp and periodontal stem cells using osteoimage assay. Osteogenic mineralization ability of dental pulp and periodontal ligament stem cells help to regenerate the bony defects in the periapical areas of the teeth. Investigating and comparing weather dental pulp or periodontal ligament stem cells aid in the mineralization ability, the objective of this study. Osteogeni

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17

Kim, Eun-Nam, Woguti Yvonne Nabende, Hyeyoon Jeong, Dongyup Hahn, and Gil-Saeng Jeong. "The Marine-Derived Natural Product Epiloliolide Isolated from Sargassum horneri Regulates NLRP3 via PKA/CREB, Promoting Proliferation and Anti-Inflammatory Effects of Human Periodontal Ligament Cells." Marine Drugs 19, no. 7 (2021): 388. http://dx.doi.org/10.3390/md19070388.

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Currently, periodontitis treatment relies on surgical operations, anti-inflammatory agents, or antibiotics. However, these treatments cause pain and side effects, resulting in a poor prognosis. Therefore, in this study, we evaluated the impact of the compound epiloliolide isolated from Sargassum horneri on the recovery of inflammatory inhibitors and loss of periodontal ligaments, which are essential treatment strategies for periodontitis. Here, human periodontal ligament cells stimulated with PG-LPS were treated with the compound epiloliolide, isolated from S. horneri. In the results of this s

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18

Adel, Ghadeer M., Ahmed A. Khalil, and Ahmed A. Moustafa. "Stem Cell with a Peri-implant Defects." NeuroQuantology 20, no. 4 (2022): 466–68. http://dx.doi.org/10.14704/nq.2022.20.4.nq22288.

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Periodontal regeneration aims are restoring of the destructed bone, cementum and periodontal ligament. The new strategies of regeneration is very challenging, one of these strategies is tissue engineering, including stem cells and it's considered very promising solution. This paper aims to review the use of stem cells for the treatment of peri-implant defects. Nowadays, many types of mesenchymal stem cells (MSCs) have the ability of periodontal regeneration in animal studies. The bone marrow MSCs (BMMSCs), dental pulp stem cell (DPSC), periodontal ligament stem cells (PDLSCs), and gingival mes

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19

Zhao, Yang, Yujia Gong, Xianbo Liu, Jia He, Bowen Zheng, and Yi Liu. "The Experimental Study of Periodontal Ligament Stem Cells Derived Exosomes with Hydrogel Accelerating Bone Regeneration on Alveolar Bone Defect." Pharmaceutics 14, no. 10 (2022): 2189. http://dx.doi.org/10.3390/pharmaceutics14102189.

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Introduction: this study was conducted to investigate the osteogenic ability of periodontal ligament stem cells (PDLSCs) derived exosomes (PDLSCs-Exos) and the effect of PDLSCs-Exos with hydrogel on alveolar bone defect repairment in the rat. Methods: the PDLSCs were obtained through primary cell culture, and PDLSCs-Exos were purified by the ultracentrifugation method. The CCK-8 kit and ALP staining were used to explore the effect of PDLSCs-Exos on promoting the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). In vivo, the alveolar bone defect models

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20

Asakawa, Takeyoshi, Atsushi Yamada, Masumi Kugino, et al. "Establishment of Down’s syndrome periodontal ligament cells by transfection with SV40T-Ag and hTERT." Human Cell 35, no. 1 (2021): 379–83. http://dx.doi.org/10.1007/s13577-021-00621-0.

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AbstractDown’s syndrome is one of the most common human congenital genetic diseases and affected patients have increased risk of periodontal disease. To examine involvement of the disease with periodontal disease development, we established immortalized periodontal ligament cells obtained from a Down’s syndrome patient by use of SV40T-Ag and hTERT gene transfection. Expressions of SV40T-Ag and hTERT were observed in periodontal ligament cell-derived immortalized cells established from healthy (STPDL) and Down’s syndrome patient (STPDLDS) samples. Primary cultured periodontal ligament cells obt

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21

Yoshizawa, Tatsuya, Fumio Takizawa, Futabako Iizawa, et al. "Homeobox Protein Msx2 Acts as a Molecular Defense Mechanism for Preventing Ossification in Ligament Fibroblasts." Molecular and Cellular Biology 24, no. 8 (2004): 3460–72. http://dx.doi.org/10.1128/mcb.24.8.3460-3472.2004.

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ABSTRACT Ligaments and tendons are comprised of tough yet flexible connective tissue. Little is known, however, about the precise characteristics of the cells in ligaments and tendons due to the absence of specific markers and cell lines. We recently reported a periodontal ligament cell line, PDL-L2, with suppressed Runx2/Osf2 transcriptional activity and an inability to form mineralized nodules. The present study demonstrates that the homeobox protein Msx2 is a key factor in suppressing those two functions. Msx2 colocalizes with Runx2/Osf2 and suppresses its activity cooperatively, acting wit

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22

Hafiedz, Maulana, and Nuzul. "The Role of Periodontal Ligament Remodeling on Orthodontic Tooth Movement." INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES 03, no. 11 (2023): 2636–40. https://doi.org/10.5281/zenodo.10319906.

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The periodontal ligament is a connective tissue located between the cementum that covers the roots of the tooth and alveolar bone, which is composed of large amounts of fibers, cells, and blood vessels. Orthodontic tooth movements are obtained through periodontal ligament remodeling and alveolar bone in response to orthodontic forces. When the orthodontic force is applied to the teeth, an injury will occur in the periodontal ligament, and the pressure and tension side in the periodontal ligament is formed. Furthermore, vasoconstriction occurs in blood vessels and hypoxia in the periodontal lig

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23

DuBois, William T., Jeffery Edmondson, Stephen B. Milam, et al. "Monoclonal Antibodies to Periodontal Ligament Cells." Journal of Periodontology 62, no. 3 (1991): 190–96. http://dx.doi.org/10.1902/jop.1991.62.3.190.

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24

Ivanovski, S., S. Gronthos, S. Shi, and PM Bartold. "Stem cells in the periodontal ligament." Oral Diseases 12, no. 4 (2006): 358–63. http://dx.doi.org/10.1111/j.1601-0825.2006.01253.x.

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25

Acharya, Aneesha, Sharath Shetty, and Vijay Deshmukh. "Periodontal Ligament Stem Cells: An Overview." Journal of Oral Biosciences 52, no. 3 (2010): 275–82. http://dx.doi.org/10.1016/s1349-0079(10)80032-5.

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26

Rose, George G., Akira Yamasaki, Gerald J. Pinero, and Charles J. Mahan. "Human periodontal ligament cells in vitro." Journal of Periodontal Research 22, no. 1 (1987): 20–28. http://dx.doi.org/10.1111/j.1600-0765.1987.tb01535.x.

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27

Uchiyama, M., Y. Nakamichi, M. Nakamura, et al. "Dental Pulp and Periodontal Ligament Cells Support Osteoclastic Differentiation." Journal of Dental Research 88, no. 7 (2009): 609–14. http://dx.doi.org/10.1177/0022034509340008.

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Odontoclasts and cementoclasts are considered to play major roles in the internal resorption of dentin and the external resorption of tooth roots. In this study, we evaluated the osteoclast-inducing ability of human dental pulp and periodontal ligament cells, which are mesenchymal cells in dental tissues. These cells expressed RANKL and OPG mRNA constitutively. As osteoclast precursors, CD14+ monocytes derived from human peripheral blood were isolated, and incubated together with human dental pulp or periodontal ligament cells. Both cell types spontaneously induced the differentiation of CD14+

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Zhang, Ying, Li Lei, and Zhimei Zeng. "Hispolon Suppresses Endoplasmic Reticulum Stress and Apoptosis of Periodontal Ligament Cells in Periodontitis." CURRENT TOPICS IN NUTRACEUTICAL RESEARCH 21, no. 4 (2023): 339–45. http://dx.doi.org/10.37290/ctnr2641-452x.21:339-345.

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In periodontitis, increased endoplasmic reticulum stress followed by apoptosis and cell death in periodontal ligament cells further exacerbates periodontium destruction. Hispolon, a traditional Chinese medicine, could attenuate cell death induced by excessive oxidation. However, its role in oxidative stress and apoptosis in periodontitis is still unclear. To this end, the effect of the increasing dosage of hispolon on the reversal of the increase in cell viability caused by lipopolysaccharide in periodontal ligament cells in a periodontitis cell model was evaluated. The results show a dose-dep

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Koskinen Holm, Cecilia, Sara Rosendahl, Per-Arne Oldenborg та Pernilla Lundberg. "The expression of signal regulatory protein alpha (SIRPα) in periodontal cells and tissue". Acta Odontologica Scandinavica 83 (11 вересня 2024): 486–92. http://dx.doi.org/10.2340/aos.v83.41391.

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Signal regulatory protein alpha (SIRPα) is mainly expressed by cells of myeloid origin. This membrane glycoprotein is shown to be involved in regulation of different inflammatory conditions, such as colitis and arthritis. However, SIRPα has not been investigated in relationship to periodontitis, an inflammatory condition affecting the tooth supporting tissues. We aim to investigate if resident cells in the periodontium express SIRPα and whether a possible expression is affected by inflammatory conditions. Primary human keratinocytes, fibroblasts, periodontal ligament cells, and osteoblasts wer

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30

Sandra, Ferry, Janti Sudiono, Ciptadhi Tri Oka Binartha, Angliana Chouw, and Melanie Sadono Djamil. "Growth and Osteogenic Differentiation of CD117+ Dental Pulp and Periodontal Ligament Cells." Indonesian Biomedical Journal 9, no. 2 (2017): 78. http://dx.doi.org/10.18585/inabj.v9i2.286.

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BACKGROUND: Dental pulp stem cell (DPSC) and periodontal ligament stem cell (PDLSC) have been suggested as valuable seed cells for bone engineering, suggesting that both stem cells are potential osteogenic sources. Since DPSC and PDLSC seem like to have similar potential in bone formation, we conducted a study to compare morphology, immunophenotype and cell growth of DPSC and PDLSC isolated from the same teeth.METHODS: Human dental pulps and periodontal ligaments were obtained from freshly extracted partial impacted third molar teeth. Collected samples were digested with type I collagenase. Re

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31

Deguchi, T., T. Yabuuchi, R. Ando, H. Ichikawa, T. Sugimoto, and T. Takano-Yamamoto. "Increase of Galanin in Trigeminal Ganglion during Tooth Movement." Journal of Dental Research 85, no. 7 (2006): 658–63. http://dx.doi.org/10.1177/154405910608500715.

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It is known that nerve fibers containing neuropeptides such as galanin increase in the periodontal ligament during experimental tooth movement. However, the origin of galanin-containing nerve fibers in the periodontal ligament remains unclear. This study was conducted to examine our hypothesis that the increased galanin nerve fibers have a sensory neuronal origin, and that the peptide is associated with pain transmission and/or periodontal ligament remodeling during experimental tooth movement. In control rats, galanin-immunoreactive trigeminal ganglion cells were very rare and were observed p

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Lee, Katie Joanna, Peter David Clegg, Eithne Josephine Comerford, and Elizabeth Gail Canty-Laird. "Ligament-Derived Stem Cells: Identification, Characterisation, and Therapeutic Application." Stem Cells International 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/1919845.

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Ligament is prone to injury and degeneration and has poor healing potential and, with currently ineffective treatment strategies, stem cell therapies may provide an exciting new treatment option. Ligament-derived stem cell (LDSC) populations have been isolated from a number of different ligament types with the majority of studies focussing on periodontal ligament. To date, only a few studies have investigated LDSC populations in other types of ligament, for example, intra-articular ligaments; however, this now appears to be a developing field. This literature review aims to summarise the curre

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Terranova, V. P., and U. M. E. Wikesjo. "Chemotaxis of Cells Isolated from Periodontal Tissues to Different Biological Response Modifiers." Advances in Dental Research 2, no. 2 (1988): 215–22. http://dx.doi.org/10.1177/08959374880020020401.

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Directed migration of many different cell types is necessary for uneventful wound healing to occur. From clinical periodontal regeneration procedures, it is commonly believed that periodontal ligament cells will be of critical importance in obtaining a new connective tissue attachment. Here we present data which indicate that extracellular matrix components (fibronectin) and polypeptide growth factors (FGF, TGF-a, and TGF-β) modulate the ability of periodontal ligament cells to express directed migration. These data indicate a potential role for matrix components and growth factors in clinical

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Mustafa, Manal, Ahmed Zarrough, Anne Isine Bolstad, et al. "Resolvin D1 protects periodontal ligament." American Journal of Physiology-Cell Physiology 305, no. 6 (2013): C673—C679. http://dx.doi.org/10.1152/ajpcell.00242.2012.

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Resolution agonists are endogenous mediators that drive inflammation to homeostasis. We earlier demonstrated in vivo activity of resolvins and lipoxins on regenerative periodontal wound healing. The goal of this study was to determine the impact of resolvin D1 (RvD1) on the function of human periodontal ligament (PDL) fibroblasts, which are critical for wound healing during regeneration of the soft and hard tissues around teeth. Primary cells were cultured from biopsies obtained from three individuals free of periodontal diseases. Peripheral blood mononuclear cells were isolated by density gra

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Onizuka, Satoru, and Takanori Iwata. "Application of Periodontal Ligament-Derived Multipotent Mesenchymal Stromal Cell Sheets for Periodontal Regeneration." International Journal of Molecular Sciences 20, no. 11 (2019): 2796. http://dx.doi.org/10.3390/ijms20112796.

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Periodontitis is a chronic inflammatory disorder that causes destruction of the periodontal attachment apparatus including alveolar bone, the periodontal ligament, and cementum. Dental implants have been routinely installed after extraction of periodontitis-affected teeth; however, recent studies have indicated that many dental implants are affected by peri-implantitis, which progresses rapidly because of the failure of the immune system. Therefore, there is a renewed focus on periodontal regeneration aroundnatural teeth. To regenerate periodontal tissue, many researchers and clinicians have a

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36

Iwayama, Tomoaki, Hiromi Sakashita, Masahide Takedachi, and Shinya Murakami. "Periodontal tissue stem cells and mesenchymal stem cells in the periodontal ligament." Japanese Dental Science Review 58 (November 2022): 172–78. http://dx.doi.org/10.1016/j.jdsr.2022.04.001.

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37

Gauthier, Rémy, Nina Attik, Charlène Chevalier, et al. "3D Electrospun Polycaprolactone Scaffolds to Assess Human Periodontal Ligament Cells Mechanobiological Behaviour." Biomimetics 8, no. 1 (2023): 108. http://dx.doi.org/10.3390/biomimetics8010108.

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While periodontal ligament cells are sensitive to their 3D biomechanical environment, only a few 3D in vitro models have been used to investigate the periodontal cells mechanobiological behavior. The objective of the current study was to assess the capability of a 3D fibrous scaffold to transmit a mechanical loading to the periodontal ligament cells. Three-dimensional fibrous polycaprolactone (PCL) scaffolds were synthetized through electrospinning. Scaffolds seeded with human periodontal cells (103 mL−1) were subjected to static (n = 9) or to a sinusoidal axial compressive loading in an in-ho

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Ohmori, Mikio, and Tsutomu Sugaya. "Regeneration of the Periodontal Ligament and Cementum by Implantation of Cultured Periodontal Ligament Cells. Histological Evaluation of Transplanted Dentin Blocks with Cultured Periodontal Ligament Cells." Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 38, no. 4 (1996): 447–56. http://dx.doi.org/10.2329/perio.38.447.

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Hosokawa, Yoshitaka, Ikuko Hosokawa, Satoru Shindo, Kazumi Ozaki та Takashi Matsuo. "IL-4 Modulates CCL11 and CCL20 Productions from IL-1β-Stimulated Human Periodontal Ligament Cells". Cellular Physiology and Biochemistry 38, № 1 (2016): 153–59. http://dx.doi.org/10.1159/000438617.

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Background/Aims: IL-4 is a multifunctional cytokine that is related with the pathological conditions of periodontal disease. However, it is uncertain whether IL-4 could control T cells migration in periodontal lesions. The aim of this study was to examine the effects of IL-4 on CCL11, which is a Th2-type chemokine, and CCL20, which is related with Th17 cells migration, productions from human periodontal ligament cells (HPDLCs). Methods: CCL20 and CCL11 productions from HPDLCs were monitored by ELISA. Western blot analysis was performed to detect phosphorylations of signal transduction molecule

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Ivanov, Alexey A., Alla V. Kuznetsova, Olga P. Popova, Tamara I. Danilova, Andrey V. Latyshev, and Oleg O. Yanushevich. "Influence of Extracellular Matrix Components on the Differentiation of Periodontal Ligament Stem Cells in Collagen I Hydrogel." Cells 12, no. 19 (2023): 2335. http://dx.doi.org/10.3390/cells12192335.

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Regeneration of periodontal tissues requires an integrated approach to the restoration of the periodontal ligament, cementum, and alveolar bone surrounding the teeth. Current strategies in endogenous regenerative dentistry widely use biomaterials, in particular the decellularized extracellular matrix (dECM), to facilitate the recruitment of populations of resident cells into damaged tissues and stimulate their proliferation and differentiation. The purpose of our study was to evaluate the effect of the exogenous components of the extracellular matrix (hyaluronic acid, laminin, fibronectin) on

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Aukhil, I., E. Pettersson, and C. Suggs. "Periodontal Wound Healing in the Absence of Periodontal Ligament Cells." Journal of Periodontology 58, no. 2 (1987): 71–77. http://dx.doi.org/10.1902/jop.1987.58.2.71.

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Nagata, Mizuki, Kengo Iwasaki, Keiko Akazawa, et al. "Conditioned Medium from Periodontal Ligament Stem Cells Enhances Periodontal Regeneration." Tissue Engineering Part A 23, no. 9-10 (2017): 367–77. http://dx.doi.org/10.1089/ten.tea.2016.0274.

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Iwasaki, K., M. Komaki, K. Mimori, E. Leon, Y. Izumi, and I. Ishikawa. "IL-6 Induces Osteoblastic Differentiation of Periodontal Ligament Cells." Journal of Dental Research 87, no. 10 (2008): 937–42. http://dx.doi.org/10.1177/154405910808701002.

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Interleukin (IL)-6 has been considered as an osteolytic factor involved in periodontal disease. However, the function of IL-6 in osteoblastic differentiation of periodontal ligament cells is not clear. We examined the effects of IL-6 and its soluble receptor (sIL-6R) on osteoblastic differentiation of periodontal ligament cells. Osteoblastic differentiation was induced by ascorbic acid. Osteoblast markers, including alkaline phosphatase activity and Runx2 gene expression, were examined. The mechanism of action of IL-6 on osteoblastic differentiation was evaluated by insulin-like growth factor

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Li, Yaoqin, Jiaqi Sun, and Huajun Zhu. "Alantolactone Alleviates Rise in Markers of Periodontitis by Lipopolysaccharide in Human Periodontal Ligament Cells." Current Topics in Nutraceutical Research 20, no. 3 (2022): 520–26. http://dx.doi.org/10.37290/ctnr2641-452x.20:520-526.

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Alantolactone, a natural sesquiterpene lactone, exerts its antiallergic, antibacterial, antimicrobial, antifungal, anticancer, and neuroprotective effects by virtue of its anti-inflammatory and antioxidant properties. We have extended these observations by examining its effect on markers of periodontitis in lipopolysaccharide treated human periodontal ligament cells. Treatment with lipopolysaccharide induced increase in cell apoptosis and decrease in cell viability that were decreased by alantolactone. Also, alantolactone suppressed lipopolysaccharide induced oxidative stress through upregulat

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Ivanov, Alexey A., Tamara I. Danilova, Alla V. Kuznetsova, Olga P. Popova, and Oleg O. Yanushevich. "Decellularized Matrix Induced Spontaneous Odontogenic and Osteogenic Differentiation in Periodontal Cells." Biomolecules 13, no. 1 (2023): 122. http://dx.doi.org/10.3390/biom13010122.

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The regeneration of periodontal tissues is a decisive factor in the treatment of periodontitis. Currently, to achieve complete periodontal regeneration, many studies have evaluated the effectiveness of decellularized tissue-engineered constructs on periodontal regeneration. We studied the possibilities of osteogenic and odontogenic differentiation of periodontal progenitor and stem cells (SCs) of the periosteum and periodontal ligament, in decellularized tooth matrix (dTM) and periodontal ligament (dPDL), in 2D and 3D culture. The cell culture of periodontal cells without decellularized matric

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Weider, Matthias, Agnes Schröder, Denitsa Docheva, et al. "A Human Periodontal Ligament Fibroblast Cell Line as a New Model to Study Periodontal Stress." International Journal of Molecular Sciences 21, no. 21 (2020): 7961. http://dx.doi.org/10.3390/ijms21217961.

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The periodontal ligament (PDL) is exposed to different kinds of mechanical stresses such as bite force or orthodontic tooth movement. A simple and efficient model to study molecular responses to mechanical stress is the application of compressive force onto primary human periodontal ligament fibroblasts via glass disks. Yet, this model suffers from the need for primary cells from human donors which have a limited proliferative capacity. Here we show that an immortalized cell line, PDL-hTERT, derived from primary human periodontal ligament fibroblasts exhibits characteristic responses to glass

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Queiroz, Aline, Emmanuel Albuquerque-Souza, Leticia Miquelitto Gasparoni, et al. "Therapeutic potential of periodontal ligament stem cells." World Journal of Stem Cells 13, no. 6 (2021): 605–18. http://dx.doi.org/10.4252/wjsc.v13.i6.605.

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Park, Gwi-woon, Hyung-shik Shin, and Hyung-keun You. "Biological characteristics of human periodontal ligament cells." Journal of the Korean Academy of Periodontology 27, no. 2 (1997): 291. http://dx.doi.org/10.5051/jkape.1997.27.2.291.

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Kaku, Masaru, Katsumi Uoshima, Yasuo Yamashita, and Hiroyuki Miura. "Investigation of periodontal ligament reaction upon excessive occlusal load - osteopontin induction among periodontal ligament cells." Journal of Periodontal Research 40, no. 1 (2005): 59–66. http://dx.doi.org/10.1111/j.1600-0765.2004.00773.x.

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Pinho, Laura C., José André Queirós, Catarina Santos, Bruno Colaço, and Maria Helena Fernandes. "Biomimetic In Vitro Model of Canine Periodontal Ligament." International Journal of Molecular Sciences 25, no. 22 (2024): 12234. http://dx.doi.org/10.3390/ijms252212234.

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Periodontal disease affects about 80% of dogs, highlighting the importance of addressing periodontitis in veterinary dental care. The periodontal ligament (PDL) is a key structure holding the potential to regenerate the entire periodontal complex. This work presents an in vitro model of canine PDL-derived cell cultures that mimic the PDL’s regenerative capacity for both mineralised and soft tissues. Explant outgrowth-derived PDL cells were cultured under standard conditions in osteoinductive medium and with hydroxyapatite nanoparticles (Hap NPs). Cell behaviour was assessed for viability/proli

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