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Naz, Irum, Aamir Mehmood Butt, Uzma Bashir, and Hina Memon. "PERIODONTAL TISSUE;." Professional Medical Journal 24, no. 06 (June 5, 2017): 930–34. http://dx.doi.org/10.29309/tpmj/2017.24.06.1115.
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Objectives: Object of present study is to determine the effect of fix orthodonticstreatment on supporting tissues. Study Design: Observational study. Place and Duration ofStudy: This study was conducted at department of orthodontics, Liaquat University HospitalJamshoro, from January 2015 to December 2015. Methodology: 60 hundred were selectedfrom orthodontic clinic opd. Inclusion criteria were to select patients with complete dentitionsapart from third molars. Pts with compromise periodontal tissue condition are excluded. All thepatients underwent oral prophylaxes and were given oral hygiene instructions at the start oforthodontic treatment. The patients were examined before the start of orthodontic treatment,after 10 months to 12 months of treatment and the periodontal health was assessed by usingCPITN (community periodontal index for treatment need) around the index teeth using WHOprobe. Results: 22(36.7%) cases out of 60 subjects were males and rest were females 38(63.3%)cases, male to female ratio 1:1.7. Means age was 20.11+1.1 years. In this study CPITN Score-0were observed in 19(31.66%) cases, Score-I in 21(35%) cases, Score-II in 14(23.33%) cases,Score-III in 5(8.33%) cases and Score-IV in 1(1.66%) case. Conclusion: Regular assessmentduring and after completion of orthodontic therapy plays big time role.
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Tobita, Morikuni, and Hiroshi Mizuno. "Periodontal Disease and Periodontal Tissue Regeneration." Current Stem Cell Research & Therapy 5, no. 2 (June 1, 2010): 168–74. http://dx.doi.org/10.2174/157488810791268672.
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Gonçalves, Gabriela Sumie Yaguinuma, Tayna Natsumi Takakura, Anderson Catelan, Rosalinda Tanuri Zaninotto Venturim, Carolina dos Santos Santinoni, and Christine Men Martins. "Tratar ou extrair? Tratamento de lesão endoperiodontal, um relato de caso clínico." ARCHIVES OF HEALTH INVESTIGATION 9, no. 6 (April 20, 2020): 535–40. http://dx.doi.org/10.21270/archi.v9i6.4814.
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Introdução: Lesões endoperiodontais são lesões originadas de produtos inflamatórios encontrados tanto em periodonto quanto em polpa. Tais lesões podem se originar devido a uma infecção pulpar ou periodontal. Visando o prognóstico favorável, é imprescindível o conhecimento da etiologia, realização do correto diagnóstico e elaboração do plano de tratamento que envolve o tratamento endodôntico precedido do tratamento periodontal. Objetivo: O propósito do presente trabalho foi de relatar um caso clínico de lesão endoperiodontal e o tratamento realizado. Relato de caso clínico: Paciente gênero feminino, 51 anos, compareceu à clínica com uma fístula na região do dente 46, procedeu-se com exame radiográfico, rastreamento de fístula, testes endodônticos e avaliação periodontal. Foi diagnosticada lesão endoperiodontal. Executou-se, então, o tratamento endodôntico em sessões múltiplas, utilizando hidróxido de cálcio como medicação intracanal e o tratamento periodontal concomitante; finalizou-se endodontia obturando-se os canais radiculares. Conclusão: Observou-se, no controle, que a associação de tratamentos foi eficaz e houve melhora significativa do quadro, constatando-se silêncio clínico e sucesso do tratamento. Realizar o tratamento conservador a despeito da exodontia foi a melhor escolha para a paciente.
Descritores: Endodontia; Periodontia; Polpa Dentária; Periodonto.
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Iwata, Takanori, Masayuki Yamato, Isao Ishikawa, Tomohiro Ando, and Teruo Okano. "Tissue Engineering in Periodontal Tissue." Anatomical Record 297, no. 1 (December 2, 2013): 16–25. http://dx.doi.org/10.1002/ar.22812.
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ALI, SARAH, NOMAAN NASIR, and BRIG® KABIR AHMED. "PERIODONTAL TISSUE DESTRUCTION." Professional Medical Journal 19, no. 04 (August 7, 2012): 522–26. http://dx.doi.org/10.29309/tpmj/2012.19.04.2273.
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Introduction: Periodontal diseases are the most common inflammatory diseases affecting the oral tissues. Objectives: Thisstudy was conducted to determine the extent of destruction of periodontal tissues in patients visiting Islamic International Dental Hospital (IIDH)and also to compare different variables e.g. age, brushing, plaque, calculus, recession, BOP, systemic diseases etc with periodontaldestruction. Design: Cross sectional study. Setting: Department of Periodontology Islamic International Dental Hospital, Islamabad. Period:November 2011 to December 2011. Materials: 80 patients 52 males and 28 females were randomly selected. A questionnaire was designedand two house officers were calibrated and trained in filling the questionnaire and examining the patient in department of Periodontology ofIslamic International Dental Hospital. Results: The results show that 25% of the patients were healthy with no loss of supporting structures. 30%of the patients had early periodontal destruction, 28% of patients had moderate periodontitis and 17% were having advanced periodontaldestruction. Periodontal destruction was more in males as compared to females and periodontal destruction increased with increasing age.Conclusions: It may be concluded from the study that prevalence of periodontitis increases with advancement of age.
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Mancini, Leonardo, Adriano Fratini, and Enrico Marchetti. "Periodontal Regeneration." Encyclopedia 1, no. 1 (January 13, 2021): 87–98. http://dx.doi.org/10.3390/encyclopedia1010011.
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Periodontal regeneration is a technique that aims to regenerate the damaged tissue around periodontally compromised teeth. The regenerative process aims to use scaffolds, cells, and growth factors to enhance biological activity.
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Nokhbehsaim, Marjan, Anna Damanaki, Andressa Vilas Boas Nogueira, Sigrun Eick, Svenja Memmert, Xiaoyan Zhou, Shanika Nanayakkara, et al. "Regulation of Ghrelin Receptor by Periodontal Bacteria In Vitro and In Vivo." Mediators of Inflammation 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/4916971.
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Ghrelin plays a major role in obesity-related diseases which have been shown to be associated with periodontitis. This study sought to analyze the expression of the functional receptor for ghrelin (GHS-R1a) in periodontal cells and tissues under microbial conditions in vitro and in vivo. The GHS-R1a expression in human periodontal cells challenged with the periodontopathogen Fusobacterium nucleatum, in gingival biopsies from periodontally healthy and diseased individuals, and from rats with and without ligature-induced periodontitis was analyzed by real-time PCR, immunocytochemistry, and immunofluorescence. F. nucleatum induced an initial upregulation and subsequent downregulation of GHS-R1a in periodontal cells. In rat experimental periodontitis, the GHS-R1a expression at periodontitis sites was increased during the early stage of periodontitis, but significantly reduced afterwards, when compared with healthy sites. In human gingival biopsies, periodontally diseased sites showed a significantly lower GHS-R1a expression than the healthy sites. The expression of the functional ghrelin receptor in periodontal cells and tissues is modulated by periodontal bacteria. Due to the downregulation of the functional ghrelin receptor by long-term exposure to periodontal bacteria, the anti-inflammatory actions of ghrelin may be diminished in chronic periodontal infections, which could lead to an enhanced periodontal inflammation and tissue destruction.
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Kawai, Mariko Yamamoto, Ryosuke Ozasa, Takuya Ishimoto, Takayoshi Nakano, Hiromitsu Yamamoto, Marina Kashiwagi, Shigeki Yamanaka, et al. "Periodontal Tissue as a Biomaterial for Hard-Tissue Regeneration following bmp-2 Gene Transfer." Materials 15, no. 3 (January 27, 2022): 993. http://dx.doi.org/10.3390/ma15030993.
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The application of periodontal tissue in regenerative medicine has gained increasing interest since it has a high potential to induce hard-tissue regeneration, and is easy to handle and graft to other areas of the oral cavity or tissues. Additionally, bone morphogenetic protein-2 (BMP-2) has a high potential to induce the differentiation of mesenchymal stem cells into osteogenic cells. We previously developed a system for a gene transfer to the periodontal tissues in animal models. In this study, we aimed to reveal the potential and efficiency of periodontal tissue as a biomaterial for hard-tissue regeneration following a bmp-2 gene transfer. A non-viral expression vector carrying bmp-2 was injected into the palate of the periodontal tissues of Wistar rats, followed by electroporation. The periodontal tissues were analyzed through bone morphometric analyses, including mineral apposition rate (MAR) determination and collagen micro-arrangement, which is a bone quality parameter, before and after a gene transfer. The MAR was significantly higher 3–6 d after the gene transfer than that before the gene transfer. Collagen orientation was normally maintained even after the bmp-2 gene transfer, suggesting that the bmp-2 gene transfer has no adverse effects on bone quality. Our results suggest that periodontal tissue electroporated with bmp-2 could be a novel biomaterial candidate for hard-tissue regeneration therapy.
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Carmagnola, Daniela, Gaia Pellegrini, Claudia Dellavia, Lia Rimondini, and Elena Varoni. "Tissue engineering in periodontology: Biological mediators for periodontal regeneration." International Journal of Artificial Organs 42, no. 5 (April 2, 2019): 241–57. http://dx.doi.org/10.1177/0391398819828558.
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Teeth and the periodontal tissues represent a highly specialized functional system. When periodontal disease occurs, the periodontal complex, composed by alveolar bone, root cementum, periodontal ligament, and gingiva, can be lost. Periodontal regenerative medicine aims at recovering damaged periodontal tissues and their functions by different means, including the interaction of bioactive molecules, cells, and scaffolds. The application of growth factors, in particular, into periodontal defects has shown encouraging effects, driving the wound healing toward the full, multi-tissue periodontal regeneration, in a precise temporal and spatial order. The aim of the present comprehensive review is to update the state of the art concerning tissue engineering in periodontology, focusing on biological mediators and gene therapy.
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Kim, Min Guk, and Chan Ho Park. "Tooth-Supporting Hard Tissue Regeneration Using Biopolymeric Material Fabrication Strategies." Molecules 25, no. 20 (October 19, 2020): 4802. http://dx.doi.org/10.3390/molecules25204802.
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The mineralized tissues (alveolar bone and cementum) are the major components of periodontal tissues and play a critical role to anchor periodontal ligament (PDL) to tooth-root surfaces. The integrated multiple tissues could generate biological or physiological responses to transmitted biomechanical forces by mastication or occlusion. However, due to periodontitis or traumatic injuries, affect destruction or progressive damage of periodontal hard tissues including PDL could be affected and consequently lead to tooth loss. Conventional tissue engineering approaches have been developed to regenerate or repair periodontium but, engineered periodontal tissue formation is still challenging because there are still limitations to control spatial compartmentalization for individual tissues and provide optimal 3D constructs for tooth-supporting tissue regeneration and maturation. Here, we present the recently developed strategies to induce osteogenesis and cementogenesis by the fabrication of 3D architectures or the chemical modifications of biopolymeric materials. These techniques in tooth-supporting hard tissue engineering are highly promising to promote the periodontal regeneration and advance the interfacial tissue formation for tissue integrations of PDL fibrous connective tissue bundles (alveolar bone-to-PDL or PDL-to-cementum) for functioning restorations of the periodontal complex.
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Villar, Cristina C., and David L. Cochran. "Regeneration of Periodontal Tissues: Guided Tissue Regeneration." Dental Clinics of North America 54, no. 1 (January 2010): 73–92. http://dx.doi.org/10.1016/j.cden.2009.08.011.
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Saito, A., E. Saito, M. Kawanami, and A. Shimada. "Healing in Transplanted Teeth with Periodontal Ligament Cultured In Vitro." Cell Transplantation 12, no. 5 (July 2003): 519–25. http://dx.doi.org/10.3727/000000003108747082.
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Regeneration of connective tissue attachment is the ultimate goal of periodontal therapy. It has been suggested that periodontal ligament cells possess the potential to create new connective tissue attachment. However, as cells from gingiva and alveolar bone occupy the root surface during initial wound healing, population by periodontal ligament cells is limited in vivo. We have been developing a new periodontal regeneration technique using in vitro tissue culture of periodontal ligament remaining on a periodontally involved root. The purpose of this study was to examine the periodontal healing after transplantation of teeth with reduced periodontal ligament that had been cultured in vitro. Twenty-five incisors from four beagles were used. After the teeth were extracted, the periodontal ligament and cementum were removed from coronal part of the roots and the roots were planed. The periodontal ligament of the apical part was retained. Fourteen teeth of the experimental group were transplanted following culture for 6 weeks. Eleven teeth of the control group were similarly prepared and immediately transplanted without tissue culture. Four weeks after transplantation, the specimens were prepared for histological analysis. Downgrowth of junctional epithelium on the root of experimental group was significantly less than control. Most of the root planed surfaces of experimental group were covered with periodontal ligament fibers oriented parallel or inclined to the root surfaces and limited new cementum formation was observed near the apical end of the planed root. There was no significant difference between groups in observations on the root surface with remaining periodontal ligament. From the above results, it was concluded that periodontal tissue culture of teeth with root planed surface and remaining periodontal ligament could reduce the extent of epithelium downgrowth and increase connective tissue adhesion on the root planed surface, as well as minimize damage to remaining periodontal ligament, after transplantation of teeth.
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Shimono, M., T. Inoue, and T. Yamamura. "Regeneration of Periodontal Tissues." Advances in Dental Research 2, no. 2 (November 1988): 223–27. http://dx.doi.org/10.1177/08959374880020020501.
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To elucidate the regenerative capability of the periodontal tissues, we carried out two experiments: (1) Regeneration of the gingival tissue following gingivectomy in rats. Ultrastructurally, regenerating junctional epithelium was similar in morphology to that of untreated animals and appeared to attach to the enamel after five days. Basal lamina and hemidesmosomes were produced faster at the enamel interface than at the connective tissue interface. Gingival tissue was completely regenerated seven days after the gingivectomy. (2) Regeneration of the cementum, periodontal ligament, and alveolar bone following intradentinal cavity preparation in dogs. In the early stages, the cavity was filled with an exudate and granulation tissue. Seven days after the operation, osteoblasts and cementoblasts were arranged regularly on the cut surface of the alveolar bone and dentin, respectively. Newly formed bone and cementum, and periodontal ligament grew to resemble pre-existing bone and cementum after 28-42 days. From these results, it is suggested that the periodontal tissues have an extremely high capability of regeneration.
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Ward, Emily. "A Review of Tissue Engineering for Periodontal Tissue Regeneration." Journal of Veterinary Dentistry 39, no. 1 (December 22, 2021): 49–62. http://dx.doi.org/10.1177/08987564211065137.
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Periodontal disease is one of the most common diagnoses in small animal veterinary medicine. This infectious disease of the periodontium is characterized by the inflammation and destruction of the supporting structures of teeth, including periodontal ligament, cementum, and alveolar bone. Traditional periodontal repair techniques make use of open flap debridement, application of graft materials, and membranes to prevent epithelial downgrowth and formation of a long junctional epithelium, which inhibits regeneration and true healing. These techniques have variable efficacy and are made more challenging in veterinary patients due to the cost of treatment for clients, need for anesthesia for surgery and reevaluation, and difficulty in performing necessary diligent home care to maintain oral health. Tissue engineering focuses on methods to regenerate the periodontal apparatus and not simply to repair the tissue, with the possibility of restoring normal physiological functions and health to a previously diseased site. This paper examines tissue engineering applications in periodontal disease by discussing experimental studies that focus on dogs and other animal species where it could potentially be applied in veterinary medicine. The main areas of focus of tissue engineering are discussed, including scaffolds, signaling molecules, stem cells, and gene therapy. To date, although outcomes can still be unpredictable, tissue engineering has been proven to successfully regenerate lost periodontal tissues and this new possibility for treating veterinary patients is discussed.
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Herawati, Herawati, and Jenny Sunariani. "THE EFFECTS OF NICOTINE ON THE PERIODONTAL TISSUE." Indonesian Journal of Tropical and Infectious Disease 1, no. 3 (September 6, 2010): 151. http://dx.doi.org/10.20473/ijtid.v1i3.2199.
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Tobacco contains thousands of chemical substances which known to be harmful to periodontal tissues. Nicotine was considered as the most toxic substances to periodontal tissues. The datas in this review indicate that smoking may have a significant role in the initiation and progression of periodontal destruction. The conclusion of this and the other studies indicate that smokers have a less favorable response to periodontal therapy than non smoker. Nicotine is potentially toxic substances that have a detrimental effect on periodontal tissue, by altering the host response or directly damage the cells of normal periodontium.
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Wiggs, Robert B., Heidi Lobprise, and Paul Q. Mitchell. "Oral and Periodontal Tissue." Veterinary Clinics of North America: Small Animal Practice 28, no. 5 (September 1998): 1165–88. http://dx.doi.org/10.1016/s0195-5616(98)50108-8.
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Bartold, P. M., S. Gronthos, S. Ivanovski, A. Fisher, and D. W. Hutmacher. "Tissue engineered periodontal products." Journal of Periodontal Research 51, no. 1 (April 21, 2015): 1–15. http://dx.doi.org/10.1111/jre.12275.
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Anuroopa, P., S. Savita, and Navnita Singh. "Revitalization of periodontally Compromised Tooth using Platelet-rich Fibrin." Journal of Health Sciences & Research 7, no. 2 (2016): 63–66. http://dx.doi.org/10.5005/jp-journals-10042-1037.
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ABSTRACT The primary objective of periodontal therapy is to gain access to the diseased sites, achieving reduction in pocket depth, arresting further disease progression, and finally restoring the periodontal tissues lost due to disease process. This can be achieved with the help of bone grafts and guided tissue regeneration. In recent times, the use of growth factors in different forms has been advocated to regulate various cell-stromal interactions in periodontal regeneration. Platelet-rich fibrin (PRF), a rich source of autologous growth factors and cytokines, is an upcoming therapeutic approach in the management of periodontal osseous defects. Platelet-rich fibrin along with the commercially available bone grafts provides a potential for enhanced bone and soft tissue regeneration. This case report focuses on saving a mandibular anterior tooth with poor prognosis using PRF and alloplast bone graft to meet with the esthetic demand of patients. How to cite this article Singh N, Anuroopa P, Savita S. Revitalization of periodontally Compromised Tooth using Platelet-rich Fibrin. J Health Sci Res 2016;7(2):63-66.
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Padmavati, P., S. Savita, B. M. Shivaprasad, Krishna Kripal, and K. Rithesh. "mRNA Expression of MMP-28 (Epilysin) in Gingival Tissues of Chronic and Aggressive Periodontitis Patients: A Reverse Transcriptase PCR Study." Disease Markers 35 (2013): 113–18. http://dx.doi.org/10.1155/2013/653982.
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Background and Objectives. Matrix metalloproteinases degrade extracellular membrane and also release bioactive fragments and growth factors, thus influencing fundamental biological and pathological processes. Epilysin (MMP-28) differs from most other MMPs as it is expressed in a number of normal tissues, suggestive of functions in tissue homeostasis. The aim of the present study was to quantitatively evaluate and compare the mRNA expression of epilysin (MMP-28) in gingival tissues of healthy patients and of patients affected by chronic or aggressive periodontitis.Methods. A total of 60 subjects, 20 periodontally healthy subjects, 20 with chronic periodontitis, and 20 with aggressive periodontitis, were included in this study. Periodontal status was evaluated by measuring gingival index, probing depth and clinical attachment level. mRNA expression of MMP-28 was determined by quantitative real-time reverse transcriptase polymerase chain reaction (RT-PCR) in gingival tissue samples collected.Results. Relative quantification of mRNA expression of MMP-28 was highest in healthy tissues () when compared to subjects with chronic periodontitis () and aggressive periodontitis (), but the difference was not statistically significant.Conclusion. mRNA expression of MMP-28 was highest in healthy tissues when compared to diseased periodontal tissues suggesting that MMP-28 could act as a biomarker for periodontal health.
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Taubman, M. A., E. D. Stoufi, G. J. Seymour, D. J. Smith, and J. L. Ebersole. "Immunoregulatory Aspects of Periodontal Disease." Advances in Dental Research 2, no. 2 (November 1988): 328–33. http://dx.doi.org/10.1177/08959374880020022201.
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This manuscript reviews our studies of the composition and functional capabilities of gingival tissue lymphocytes from patients with periodontal disease. The emphasis has been on phenotyping the local lymphoid infiltration in gingival and periodontal disease. The preparation and phenotypic analyses of cells recovered from diseased and healthy human periodontal tissues indicated that T-cell subset ratios from diseased tissue were significantly decreased compared with peripheral blood or normal tissue ratios. These reductions were verified in a second study we performed using two-color immunofluorescence analyzed by flow cytofluorometry. Local variations in the CD4 + cell population were also found in diseased tissue cells when these were compared with normal tissue cells. The relative percentage of CD4+ cells labeled with anti-helper inducer (4B4) or anti-suppressor inducer (2H4) monoclonal antibodies was increased above that of normal tissue cells. Functional studies of immunoglobulin production by gingival cells from adult periodontitis tissues showed two discrete patterns of synthesis and also suppression of immunoglobulin synthesis after addition of mitogen to the cultures. Removal of macrophages also drastically reduced immunoglobulin synthesis by gingival cells. These results indicate that there is an abundance of suppressor T-cells in diseased tissue and that functional suppression is demonstrated by lymphocytes from periodontal disease tissue. The findings of these investigations have suggested potentially important roles for immune regulation in periodontal disease.
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Monea, Adriana, Tibor Mezei, Sorin Popsor, and Monica Monea. "Oxidative Stress: A Link between Diabetes Mellitus and Periodontal Disease." International Journal of Endocrinology 2014 (2014): 1–4. http://dx.doi.org/10.1155/2014/917631.
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Objective. To investigate oxidative stress (OS) and histological changes that occur in the periodontium of subjects with type 2 diabetes mellitus without signs of periodontal disease and to establish if oxidative stress is a possible link between diabetes mellitus and periodontal changes.Materials and Methods. Tissue samples from ten adult patients with type 2 diabetes mellitus (T2D) and eight healthy adults were harvested. The specimens were examined by microscope using standard hematoxylin-eosin stain, at various magnifications, and investigated for tissue levels of malondialdehyde (MDA) and glutathione (GSH).Results. Our results showed that periodontal tissues in patients with T2D present significant inflammation, affecting both epithelial and connective tissues. Mean MDA tissue levels were 3.578 ± 0.60 SD in diabetics versus 0.406 ± 0.27 SD in controls (P< 0.0001), while mean GSH tissue levels were 2.48 ± 1.02 SD in diabetics versus 9.7875 ± 2.42 SD in controls (P< 0.0001).Conclusion. Diabetic subjects had higher MDA levels in their periodontal tissues, suggesting an increased lipid peroxidation in T2D, and decreased GSH tissue levels, suggesting an alteration of the local antioxidant defense mechanism. These results are in concordance with the histological changes that we found in periodontal tissues of diabetic subjects, confirming the hypothesis of OS implication, as a correlation between periodontal disease incidence and T2D.
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Mody, Dhawal Rajendra, Vrushali Lathiya, and Kamalkishor Mankar. "Periostin in Periodontics: A Brief Insight." International Journal of Science and Healthcare Research 6, no. 2 (May 22, 2021): 147–49. http://dx.doi.org/10.52403/ijshr.20210426.
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The prime objective of the periodontal treatment is to re-establish the lost periodontal tissue by forming new attachment of periodontal ligament, cementum and the alveolar bone. Periostin is a matricellular protein with its structure closely resembling to that of Drosophila fasciclin. It is expressed in the periodontal ligament, periosteum, alveolar bone, adipose tissue as well as skeletal tissue and has a key role in role in tooth development. This protein molecule has a striking similarity to the molecule beta ig-h3 which is induced by transforming growth factor beta (TGF-beta), promotes the adhesion and spreading of fibroblasts and aids in collagen formation. It is possibly involved in the post surgical regeneration of periodontal hard and soft tissues. Periostin is also linked to dental papilla cells and is associated with hard tissue formation stages of tooth development. This mini review focuses on the various aspects of periostin related to maintenance and development of collagen rich connective tissues around the teeth. Keywords: Periostin, Periodontal ligament, Periodontal regeneration, Alveolar bone.
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Yu, Na, Daniel A. W. Oortgiesen, Antonius L. J. J. Bronckers, Fang Yang, X. Frank Walboomers, and John A. Jansen. "Enhanced periodontal tissue regeneration by periodontal cell implantation." Journal of Clinical Periodontology 40, no. 7 (May 15, 2013): 698–706. http://dx.doi.org/10.1111/jcpe.12113.
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Dankevych-Kharchyshyn, Iryna S., Olena M. Vynogradova, Natalia V. Malko, Roman M. Gnid, Andriana P. Skalat, Lidiya Y. Minko, Oleg I. Mrochko, Yurij L. Bandrivsky, and Orysia O. Bandrivska. "PERIODONTAL DISEASES AND ATHEROSCLEROSIS (LITERATURE REVIEW)." Wiadomości Lekarskie 72, no. 3 (2019): 462–65. http://dx.doi.org/10.36740/wlek201903127.
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Introduction: The relationship between periodontal diseases and atherosclerosis is addressed in this article. Both these diseases have an inflammatory basis. Because periodontal disease is a risk factor for developing atherosclerotic vascular disease, diagnosis of the former is important. Particular attention must be paid to patients who have periodontal disease with other risk factors for atherosclerotic vascular disease. Recommendations managing these patients have been made included. The aim: The paper is aimed at familiarization of broad medical public with the presence of the relationship between diseases of periodontal tissues and atherosclerosis. Materials and methods: A thorough comprehensive analysis and generalization of scientific achievements elucidated in the fundamental and periodical publications, relating to diseases of the periodontal tissues and atherosclerosis, has been carried out. Review: The article consists of many researchers regarding the prevalence and intensity of periodontal tissue diseases in people of all ages. Problems associated with the state of periodontal tissues in people under study as dentists and general practitioners. Proven role in the pathogenesis of inflammatory diseases of the periodontal tissues in people with atherosclerosis. In the modern concept of the etiology and pathogenesis of periodontal diseases in people is extremely important role for the immune system and resistance to periodontal bacterial invasion. Analyzed common changes important for pathogenesis of periodontal tissue diseases and atherosclerosis. Conclusions: Consequently, recent studies have shown a clear, directly proportional relationship between periodontal tissue diseases and atherosclerosis, but mechanisms for their development and interaction are not fully disclosed.
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Seo, B. M., M. Miura, W. Sonoyama, C. Coppe, R. Stanyon, and S. Shi. "Recovery of Stem Cells from Cryopreserved Periodontal Ligament." Journal of Dental Research 84, no. 10 (October 2005): 907–12. http://dx.doi.org/10.1177/154405910508401007.
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Human post-natal stem cells possess a great potential to be utilized in stem-cell-mediated clinical therapies and tissue engineering. It is not known whether cryopreserved human tissues contain functional post-natal stem cells. In this study, we utilized human periodontal ligament to test the hypothesis that cryopreserved human periodontal ligament contains retrievable post-natal stem cells. These cryopreserved periodontal ligament stem cells maintained normal periodontal ligament stem cell characteristics, including expression of the mesenchymal stem cell surface molecule STRO-1, single-colony-strain generation, multipotential differentiation, cementum/periodontal-ligament-like tissue regeneration, and a normal diploid karyotype. Collectively, this study provides valuable evidence demonstrating a practical approach to the preservation of solid-frozen human tissues for subsequent post-natal stem cell isolation and tissue regeneration. The present study demonstrates that human post-natal stem cells can be recovered from cryopreserved human periodontal ligament, thereby providing a practical clinical approach for the utilization of frozen tissues for stem cell isolation.
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Tayman, Mahmure A., Canan Önder, Şivge Kurgan, Muhittin A. Serdar, and Meral Günhan. "A Novel Systemic Indicator of Periodontal Tissue Damage: Ischemia Modified Albumin." Combinatorial Chemistry & High Throughput Screening 21, no. 8 (December 17, 2018): 544–49. http://dx.doi.org/10.2174/1386207321666181018165255.
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Background: Ischemia-modified albumin (IMA) is a systemic indicator of inflammatory diseases and is suggested as an oxidative stress marker. Objective: To determine the IMA and high-sensitivity C-reactive protein (hsCRP) serum levels for patients with chronic periodontitis (CP) and to evaluate the impact of non-surgical periodontal therapy on serum IMA and hsCRP levels. Methods: Twenty one systemically healthy patients with CP and 15 systemically and periodontally healthy controls (C) were enrolled in the study. Periodontal pocket depth (PPD), bleeding on probing (BOP) and attachment loss (AL) were recorded at the time of diagnosis and 6 weeks after the nonsurgical periodontal therapy. Blood samples were obtained before and after treatment from all groups, and serum IMA and hsCRP levels were evaluated by ELISA method. Results: All of the clinical findings were found to be elevated in the CP group in comparison to C group (p<0.05). Levels of IMA and hsCRP were higher in the CP group (p<0.05) and decreased after non-surgical periodontal therapy (p<0.05). Positive correlations were determined between PPD, BOP and hsCRP (p<0.05) as well as between PPD, AL, BOP and IMA levels (p<0.01) before treatment. A significant positive correlation was also observed between hsCRP and IMA (p<0.01) before and after treatment. Conclusion: IMA is a marker indicating systemic inflammation during periodontal disease, and is significantly reduced as a result of non-surgical periodontal therapy. Therefore, IMA might be suggested as a useful indicator of periodontal disease.
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Goker, Funda, Lena Larsson, Massimo Del Fabbro, and Farah Asa’ad. "Gene Delivery Therapeutics in the Treatment of Periodontitis and Peri-Implantitis: A State of the Art Review." International Journal of Molecular Sciences 20, no. 14 (July 20, 2019): 3551. http://dx.doi.org/10.3390/ijms20143551.
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Background: Periodontal disease is a chronic inflammatory condition that affects supporting tissues around teeth, resulting in periodontal tissue breakdown. If left untreated, periodontal disease could have serious consequences; this condition is in fact considered as the primary cause of tooth loss. Being highly prevalent among adults, periodontal disease treatment is receiving increased attention from researchers and clinicians. When this condition occurs around dental implants, the disease is termed peri-implantitis. Periodontal regeneration aims at restoring the destroyed attachment apparatus, in order to improve tooth stability and thus reduce disease progression and subsequent periodontal tissue breakdown. Although many biomaterials have been developed to promote periodontal regeneration, they still have their own set of disadvantages. As a result, regenerative medicine has been employed in the periodontal field, not only to overcome the drawbacks of the conventional biomaterials but also to ensure more predictable regenerative outcomes with minimal complications. Regenerative medicine is considered a part of the research field called tissue engineering/regenerative medicine (TE/RM), a translational field combining cell therapy, biomaterial, biomedical engineering and genetics all with the aim to replace and restore tissues or organs to their normal function using in vitro models for in vivo regeneration. In a tissue, cells are responding to different micro-environmental cues and signaling molecules, these biological factors influence cell differentiation, migration and cell responses. A central part of TE/RM therapy is introducing drugs, genetic materials or proteins to induce specific cellular responses in the cells at the site of tissue repair in order to enhance and improve tissue regeneration. In this review, we present the state of art of gene therapy in the applications of periodontal tissue and peri-implant regeneration. Purpose: We aim herein to review the currently available methods for gene therapy, which include the utilization of viral/non-viral vectors and how they might serve as therapeutic potentials in regenerative medicine for periodontal and peri-implant tissues.
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Cho, Young-Dan, Kyoung-Hwa Kim, Yong-Moo Lee, Young Ku, and Yang-Jo Seol. "Periodontal Wound Healing and Tissue Regeneration: A Narrative Review." Pharmaceuticals 14, no. 5 (May 12, 2021): 456. http://dx.doi.org/10.3390/ph14050456.
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Periodontal disease is a major public health issue, and various periodontal therapies have been performed to regenerate periodontal tissues. The periodontium is a complex structure composed of specialized tissues that support the teeth, and most periodontal surgeries are invasive procedures, including a resection of the gingiva or the alveolar bone. The periodontal wound healing process is slightly different from cutaneous wound healing and is similar to fetal healing, being almost scar-free. The aim of this review article is to provide an overview of periodontal wound healing and discuss various surgical and pharmaceutical approaches to achieve stable wound healing and improve the treatment outcomes. In addition, detrimental and limiting factors that induce a compromised prognosis are discussed, along with the perspective and future direction for successful periodontal tissue regeneration.
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Nardi, Gianna Maria, Elisabetta Ferrara, Ilaria Converti, Francesca Cesarano, Salvatore Scacco, Roberta Grassi, Antonio Gnoni, Felice Roberto Grassi, and Biagio Rapone. "Does Diabetes Induce the Vascular Endothelial Growth Factor (VEGF) Expression in Periodontal Tissues? A Systematic Review." International Journal of Environmental Research and Public Health 17, no. 8 (April 16, 2020): 2765. http://dx.doi.org/10.3390/ijerph17082765.
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Aim: Diabetes and periodontal disease are both chronic pathological conditions linked by several underlying biological mechanisms, in which the inflammatory response plays a critical role, and their association has been largely recognized. Recently, attention has been given to diabetes as an important mediator of vascular endothelial growth factor (VEGF) overexpression in periodontal tissues, by virtue of its ability to affect microvasculature. This review aims to summarize the findings from studies that explored VEGF expression in diabetic patients with periodontitis, compared to periodontally healthy subjects. Materials and Methods: A systematic literature review was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A PubMed search of select medical subject heading (MeSH) terms was carried out to identify all studies reporting findings about VEGF expression in periodontal tissues of diabetic patients up to May 2018. The inclusion criteria were studies on VEGF expression in periodontally diseased tissues of diabetic patients compared with nondiabetic subjects, with any method of analysis, and published in the English language. Results: Eight articles met the inclusion criteria. Immunohistochemistry was used in six of the studies, reverse transcriptase polymerase chain reaction (real-time RT-PCR) aiming to quantify mRNA VEGF expression was used in one study, and ELISA analysis was used for one study. Compared with nondiabetic patients, a higher VEGF expression in gingival tissue and gingival crevicular fluid (GCF) samples in diabetic patients with periodontitis was reported. Conclusions: Overall, novel evidence for the VEGF expression within the periodontal tissue of diabetic patients paves the way for further studies on the role of this protein in neovascularization physiology and pathophysiology in microvasculature of the periodontium.
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Smalley, J. W. "Pathogenic Mechanisms in Periodontal Disease." Advances in Dental Research 8, no. 2 (July 1994): 320–28. http://dx.doi.org/10.1177/08959374940080022801.
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Periodontal diseases have been considered as "infections" in which micro-organisms initiate and maintain the destructive inflammatory response. Host-mediated tissue destruction occurs via complement activation and the release of lysosomal enzymes, and connective tissue matrix metalloproteinases. Microbial enzymes may damage connective tissues directly, and, together with toxic metabolites and structural materials, are thought to disrupt the reparative activities of fibroblasts and cells of the immune defenses. The significance and relative contributions of host and microbial factors to the disease process remain unresolved. Environmental changes in the gingival sulcus and periodontal pocket and tissues, the degree of the host response and nutrient availability, concomitant with disease progression, compromise tissue metabolism and repair, and allow for enhanced or de novo expression of microbial virulence factors, such as proteases, which alter microbial pathogenicity. Proteolytic destruction of specific antibodies and complement by both viable and non-viable bacterial cells may retard phagocytic killing and removal of pathogens, thus prolonging the inflammatory response. Bacterial products may indirectly mediate tissue destruction by stimulating release of matrix metalloproteinases or by proteolytically inactivating the specific inhibitors of these enzymes.
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Kordiyak, Olena J. "Periodontal Destruction and Regeneration in Experimental Models: Combined Research Approaches." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 5, no. 5 (October 24, 2020): 28–34. http://dx.doi.org/10.26693/jmbs05.05.028.
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Chronic periodontitis is a common dental disease, resulting in destruction of gingival tissue, periodontal ligament, cementum, alveolar bone and, consequently- teeth loss in the adult population. Experimental animal models have enabled the study of periodontal disease pathogenesis and are used to test new therapeutic approaches for treating the disease The purpose of this review study was to draw the evidence from animal models, required for future assessment of destructional and regenerative processes in periodontal tissues. Material and methods: a rat experimental periodontitis models of ligature, streptozotocin, and immune complexes induced periodontitis, periodontal defect, altered functional loading, stress exposures and surgically created chronic acid reflux esophagitis models. Histomorphomorphological/-metrical, immunohisto (-cyto)chemical and histopathological analysis, micro-computed tomography, scanning and transmission electron microscopy, polarizing light and confocal microscopy, spectrophotometry, radiographic and biomechanical analysis, descriptive histology and computer-assisted image analysis. Results and discussion. Scaling and root planing may not always be effective in preventing periodontal disease progression, and, moreover, with currently available therapies, full regeneration of lost periodontal tissues after periodontitis cannot be achieved. However, in 70.5% of the results of experimental studies reported, irrespective of the defect type and animal model used, beneficial outcome for periodontal regeneration after periodontal ligament stem cell implantation, including new bone, new cementum and new connective tissue formation, was recorded. Therefore, platelet-rich fibrin combined with rat periodontal ligament stem cells provides a useful instrument for periodontal tissue engineering. Conclusion. There is sufficient evidence from preclinical animal studies suggesting that periodontal tissue engineering would provide a valuable tool for periodontal regeneration. Further elaboration of the developed in preclinical studies experimental techniques should justify progress to clinical studies and subsequent medical application
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Varghese, Jothi, and Rudra Mohan. "Bioscaffolds in Periodontal Regeneration." Nanoscience & Nanotechnology-Asia 9, no. 4 (November 25, 2019): 428–36. http://dx.doi.org/10.2174/2210681208666180604092506.
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Background: Tissue engineering is a highly evolving field in periodontology which incorporates the use of cells, signalling molecules and scaffolds thereby creating a three dimensional microenvironment facilitating cellular growth and function for restoration of lost tissues due to periodontal disease. This review discusses the various types, ideal characteristics, properties and applications of potential scaffolds that can be used in periodontal regeneration with the help of principles of tissue engineering. Methods: Research work pertaining to bioscaffolds for periodontal regeneration were selected using key words in major databases and internet sources. Results: Studies related to various features of scaffold and its inherent properties were searched and analysed. Data were organized considering the sources of its origin and salient features of these inert matrices. Specific probe into the techniques and medium used for developing scaffolds were cited. Further, bioactive ceramic materials which are involved in stimulating cell proliferation, and bone tissue regeneration, which may also facilitate periodontal regeneration were mentioned. Likewise, few data linked to different types of biodegradable synthetic scaffolds and its advantages were considered. The progress of science in various fabrication techniques and newer advances using modern technology such as tissue engineering approaches, 3D printing and physical & chemical methods to enhance the physical properties are being used to make them more versatile for the application in the field of biomedical science. Conclusion: In lieu of the available literature search and vast progress in material science, scaffolds construction for cellular regeneration requires wide exploration. Furthermore, when these scaffolds are placed at a particular site, it should be able to restore lost periodontal tissue. Also, the newer innovative technologies like the 3D version of biomimicking, nano/micro-based scaffolds displays potential for further extensive research and complete regeneration of periodontal tissues.
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Kasugai, Shohei. "Characteristics of periodontal ligament and regeneration of periodontal tissue." Ensho Saisei 23, no. 1 (2003): 34–38. http://dx.doi.org/10.2492/jsir.23.34.
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Park, Chan Ho. "Biomaterial-Based Approaches for Regeneration of Periodontal Ligament and Cementum Using 3D Platforms." International Journal of Molecular Sciences 20, no. 18 (September 5, 2019): 4364. http://dx.doi.org/10.3390/ijms20184364.
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Currently, various tissue engineering strategies have been developed for multiple tissue regeneration and integrative structure formations as well as single tissue formation in musculoskeletal complexes. In particular, the regeneration of periodontal tissues or tooth-supportive structures is still challenging to spatiotemporally compartmentalize PCL (poly-ε-caprolactone)-cementum constructs with micron-scaled interfaces, integrative tissue (or cementum) formations with optimal dimensions along the tooth-root surfaces, and specific orientations of engineered periodontal ligaments (PDLs). Here, we discuss current advanced approaches to spatiotemporally control PDL orientations with specific angulations and to regenerate cementum layers on the tooth-root surfaces with Sharpey’s fiber anchorages for state-of-the-art periodontal tissue engineering.
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Alquthami, Hind, Abdulaziz M. Almalik, Faisal F. Alzahrani, and Lana Badawi. "Successful Management of Teeth with Different Types of Endodontic-Periodontal Lesions." Case Reports in Dentistry 2018 (May 29, 2018): 1–7. http://dx.doi.org/10.1155/2018/7084245.
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Endodontic-periodontal diseases often present great challenges to the clinician in their diagnosis, management, and prognosis. Understanding the disease process through cause-and-effect relationships between the pulp and supporting periodontal tissues with the aid of rational classifications leads to successful treatment outcomes. In this report, we present several treatment modalities in patients with different endodontic-periodontal lesions. A modification to the new endodontic-periodontic classification, Al-Fouzan’s classification, was also added. The first case was classified as retrograde periodontal disease (i.e., primary endodontic lesion with drainage through the periodontal ligament). The second case was diagnosed as an iatrogenic periodontal lesion caused by root perforation. The third case was diagnosed as an iatrogenic periodontal lesion caused by tooth trauma due to orthodontic treatment. The first two cases were managed with a nonsurgical approach, whereas the third case was managed with nonsurgical and surgical approaches. All patients showed complete healing of soft and hard tissue lesions. A thorough understanding of the disease history and the patient’s signs and symptoms, complete examination with full investigation, and the use of a systematic step-by-step approach in the management of such challenging endodontic-periodontal lesions with regular recall visits were very useful and successful.
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Jiao, Kexin, Laurence J. Walsh, Sašo Ivanovski, and Pingping Han. "The Emerging Regulatory Role of Circular RNAs in Periodontal Tissues and Cells." International Journal of Molecular Sciences 22, no. 9 (April 28, 2021): 4636. http://dx.doi.org/10.3390/ijms22094636.
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Periodontitis is a chronic complex inflammatory disease associated with a destructive host immune response to microbial dysbiosis, leading to irreversible loss of tooth-supporting tissues. Regeneration of functional periodontal soft (periodontal ligament and gingiva) and hard tissue components (cementum and alveolar bone) to replace lost tissues is the ultimate goal of periodontal treatment, but clinically predictable treatments are lacking. Similarly, the identification of biomarkers that can be used to accurately diagnose periodontitis activity is lacking. A relatively novel category of molecules found in oral tissue, circular RNAs (circRNAs) are single-stranded endogenous, long, non-coding RNA molecules, with covalently circular-closed structures without a 5’ cap and a 3’ tail via non-classic backsplicing. Emerging research indicates that circRNAs are tissue and disease-specific expressed and have crucial regulatory functions in various diseases. CircRNAs can function as microRNA or RNA binding sites or can regulate mRNA. In this review, we explore the biogenesis and function of circRNAs in the context of the emerging role of circRNAs in periodontitis pathogenesis and the differentiation of periodontal cells. CircMAP3K11, circCDK8, circCDR1as, circ_0062491, and circ_0095812 are associated with pathological periodontitis tissues. Furthermore, circRNAs are expressed in periodontal cells in a cell-specific manner. They can function as microRNA sponges and can form circRNA–miRNA–mRNA networks during osteogenic differentiation for periodontal-tissue (or dental pulp)-derived progenitor cells.
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Rodrigues, Ariana Larissa de Moura, Ana Carolina de Sá Gomes Cruz Souza, Jéssica Gomes Alcoforado de Melo, and Diego Moura Soares. "Lesões em áreas de furca: fatores etiológicos, diagnóstico e tratamento." ARCHIVES OF HEALTH INVESTIGATION 9, no. 6 (December 20, 2020): 635–40. http://dx.doi.org/10.21270/archi.v9i6.5110.
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As lesões de furca ocorrem quando a doença periodontal atinge a área de bifurcação dos dentes multirradiculares causando a destruição óssea e perda de inserção no espaço inter-radicular. Existem diversos fatores etiológicos que influenciam no aparecimento dessas lesões e até os dias de hoje o tratamento desse tipo de injúria ainda é um desafio na clínica odontológica. O objetivo deste artigo foi listar, através de uma revisão da literatura, os fatores que influenciam na etiologia da lesão de furca, bem como o seu diagnóstico, prognóstico e tratamento. Fatores como características morfológicas do dente e raiz e deficiência no controle do biofilme, que podem contribuir para o seu aparecimento. Além de diversos tipos de procedimentos e técnicas têm sido propostas para o tratamento das lesões de furca, seja mais ou menos conservadores.
Descritores: Defeitos da Furca; Diagnóstico; Doenças Periodontais.
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Sordi, Mariane Beatriz, Ricardo de Souza Magini, Layla Panahipour, and Reinhard Gruber. "Pyroptosis-Mediated Periodontal Disease." International Journal of Molecular Sciences 23, no. 1 (December 29, 2021): 372. http://dx.doi.org/10.3390/ijms23010372.
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Pyroptosis is a caspase-dependent process relevant to the understanding of beneficial host responses and medical conditions for which inflammation is central to the pathophysiology of the disease. Pyroptosis has been recently suggested as one of the pathways of exacerbated inflammation of periodontal tissues. Hence, this focused review aims to discuss pyroptosis as a pathological mechanism in the cause of periodontitis. The included articles presented similarities regarding methods, type of cells applied, and cell stimulation, as the outcomes also point to the same direction considering the cellular events. The collected data indicate that virulence factors present in the diseased periodontal tissues initiate the inflammasome route of tissue destruction with caspase activation, cleavage of gasdermin D, and secretion of interleukins IL-1β and IL-18. Consequently, removing periopathogens’ virulence factors that trigger pyroptosis is a potential strategy to combat periodontal disease and regain tissue homeostasis.
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Malizia, Tecla, Milvana R. Tejada, Emilia Ghelardi, Sonia Senesi, Mario Gabriele, Maria R. Giuca, Corrado Blandizzi, Romano Danesi, Mario Campa, and Mario Del Tacca. "Periodontal Tissue Disposition of Azithromycin." Journal of Periodontology 68, no. 12 (December 1997): 1206–9. http://dx.doi.org/10.1902/jop.1997.68.12.1206.
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Dentino, A. "Tissue Engineering for Periodontal Regeneration." Yearbook of Dentistry 2006 (January 2006): 87. http://dx.doi.org/10.1016/s0084-3717(08)70078-3.
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Djajakusuma, Hutojo. "Periodontal tissue damage in smokers." Dental Journal (Majalah Kedokteran Gigi) 39, no. 3 (September 1, 2006): 107. http://dx.doi.org/10.20473/j.djmkg.v39.i3.p107-111.
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MUNEKATA, Masanobu, and Kazuaki NISHIMURA. "Regeneration Cascade in Periodontal Tissue." Kagaku To Seibutsu 37, no. 3 (1999): 164–71. http://dx.doi.org/10.1271/kagakutoseibutsu1962.37.164.
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Delaney, Jayne E. "PERIODONTAL AND SOFT-TISSUE ABNORMALITIES." Dental Clinics of North America 39, no. 4 (October 1995): 837–50. http://dx.doi.org/10.1016/s0011-8532(22)00625-5.
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Cahaya, Cindy, and Sri Lelyati C. Masulili. "Perkembangan Terkini Membran Guided Tissue Regeneration/Guided Bone Regeneration sebagai Terapi Regenerasi Jaringan Periodontal." Majalah Kedokteran Gigi Indonesia 1, no. 1 (June 1, 2015): 1. http://dx.doi.org/10.22146/majkedgiind.8810.
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Periodontitis adalah salah satu penyakit patologis yang mempengaruhi integritas sistem periodontal yang menyebabkan kerusakan jaringan periodontal yang berlanjut pada kehilangan gigi. Beberapa tahun belakangan ini banyak ketertarikan untuk melakukan usaha regenerasi jaringan periodontal, tidak saja untuk menghentikan proses perjalanan penyakit namun juga mengembalikan jaringan periodontal yang telah hilang. Sasaran dari terapi regeneratif periodontal adalah menggantikan tulang, sementum dan ligamentum periodontal pada permukaan gigi yang terkena penyakit. Prosedur regenerasi antara lain berupa soft tissue graft, bone graft, biomodifikasi akar gigi, guided tissue regeneration sertakombinasi prosedur-prosedur di atas, termasuk prosedur bedah restoratif yang berhubungan dengan rehabilitasi oral dengan penempatan dental implan. Pada tingkat selular, regenerasi periodontal adalah proses kompleks yang membutuhkan proliferasi yang terorganisasi, differensiasi dan pengembangan berbagai tipe sel untuk membentuk perlekatan periodontal. Rasionalisasi penggunaan guided tissue regeneration sebagai membran pembatas adalah menahan epitel dan gingiva jaringan pendukung, sebagai barrier membrane mempertahankan ruang dan gigi serta menstabilkan bekuan darah. Pada makalah ini akan dibahas sekilas mengenai 1. Proses penyembuhan terapi periodontal meliputi regenerasi, repair ataupun pembentukan perlekatan baru. 2. Periodontal spesific tissue engineering. 3. Berbagai jenis membran/guided tissue regeneration yang beredar di pasaran dengan keuntungan dan kerugian sekaligus karakteristik masing-masing membran. 4. Perkembangan membran terbaru sebagai terapi regenerasi penyakit periodontal. Tujuan penulisan untuk memberi gambaran masa depan mengenai terapi regenerasi yang menjanjikan sebagai perkembangan terapi penyakit periodontal. Latest Development of Guided Tissue Regeneration and Guided Bone Regeneration Membrane as Regenerative Therapy on Periodontal Tissue. Periodontitis is a patological state which influences the integrity of periodontal system that could lead to the destruction of the periodontal tissue and end up with tooth loss. Currently, there are so many researches and efforts to regenerate periodontal tissue, not only to stop the process of the disease but also to reconstruct the periodontal tissue. Periodontal regenerative therapy aims at directing the growth of new bone, cementum and periodontal ligament on the affected teeth. Regenerative procedures consist of soft tissue graft, bone graft, roots biomodification, guided tissue regeneration and combination of the procedures, including restorative surgical procedure that is connected with oral rehabilitation with implant placement. At cellular phase, periodontal regeneration is a complex process with well-organized proliferation, distinction, and development of various type of cell to form attachment of periodontal tissue. Rationalization of the use of guided tissue regeneration as barrier membrane is to prohibit the penetration of epithelial and connective tissue migration into the defect, to maintain space, and to stabilize the clot. This research discusses: 1. Healing process on periodontal therapy including regeneration, repair or formation of new attachment. 2. Periodontal specific tissue engineering. 3. Various commercially available membrane/guided tissue regeneration in the market with its advantages and disadvantages and their characteristics. 4. Recent advancement of membrane as regenerative therapy on periodontal disease. In addition, this review is presented to give an outlook for promising regenerative therapy as a part of developing knowledge and skills to treat periodontal disease.
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Fan, Liping, and Dan Wu. "Enamel Matrix Derivatives for Periodontal Regeneration: Recent Developments and Future Perspectives." Journal of Healthcare Engineering 2022 (April 11, 2022): 1–10. http://dx.doi.org/10.1155/2022/8661690.
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In the era of the growing population, the demand for dental care is increasing at a fast pace for both older and younger people. One of the dental diseases that has attracted significant research is periodontitis. Periodontal therapy aims to regenerate tissues that are injured by periodontal disease. During recent decades, various pioneering strategies and products have been introduced for restoring or regeneration of periodontal deficiencies. One of these involves the regeneration of tissues under guidance using enamel matrix derivatives (EMDs) or combinations of these. EMDs are mainly comprised of amelogenins, which is one of the most common biological agents used in periodontics. Multiple studies have been reported regarding the role of EMD in periodontal tissue regeneration; however, the extensive mechanism remains elusive. The EMDs could promote periodontal regeneration mainly through inducing periodontal attachment during tooth formation. EMD mimics biological processes that occur during periodontal tissue growth. During root development, enamel matrix proteins are formed on the root surface by Hertwig’s epithelial root sheath cells, initiating the process of cementogenesis. This article reviews the challenges and recent advances in preclinical and clinical applications of EMDs in periodontal regeneration. Moreover, we discuss the current evidence on the mechanisms of action of EMDs in the regeneration of periodontal tissues.
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Kajiya, Mikihito, and Hidemi Kurihara. "Molecular Mechanisms of Periodontal Disease." International Journal of Molecular Sciences 22, no. 2 (January 19, 2021): 930. http://dx.doi.org/10.3390/ijms22020930.
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Periodontal disease, one of the most prevalent human infectious diseases, is characterized by chronic inflammatory tissue destruction of the alveolar bone and the connective tissues supporting the tooth [...]
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Ahmad, Paras, Martin J. Stoddart, and Elena Della Bella. "The Role of Noncoding RNAs in Osteogenic Differentiation of Human Periodontal Ligament Stem Cells." Craniomaxillofacial Trauma & Reconstruction Open 6 (January 1, 2021): 247275122199922. http://dx.doi.org/10.1177/2472751221999229.
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Chronic inflammatory diseases, including periodontitis, are the most common causes of bone tissue destruction. Periodontitis often leads to loss of connective tissue homeostasis and reduced alveolar bone levels. Human periodontal ligament stem cells (PDLSCs), a population of multipotent stem cells derived from periodontal ligament tissues, are considered as candidate cells for the regeneration of alveolar bone and periodontal tissues. Periodontitis impairs the osteogenic differentiation of human PDLSCs. Noncoding RNAs (ncRNAs), including long noncoding RNA (lncRNA), microRNA (miRNA), and circular RNA (circRNA), have been proposed as vital regulators influencing several differentiation processes including bone regeneration. Still, the molecular mechanisms of ncRNAs regulating osteogenic differentiation of human PDLSCs remain poorly understood. Exploring the influence of ncRNAs in the process of osteogenic differentiation of human PDLSCs may provide novel therapeutic strategies for tissue regeneration as the regeneration of the lost periodontium is the ultimate goal of periodontal therapy.
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Huang, Qiuxia, Xin Huang, and Lisha Gu. "Periodontal Bifunctional Biomaterials: Progress and Perspectives." Materials 14, no. 24 (December 10, 2021): 7588. http://dx.doi.org/10.3390/ma14247588.
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Periodontitis is a chronic infectious disease that destroys periodontal supportive tissues and eventually causes tooth loss. It is attributed to microbial and immune factors. The goal of periodontal therapy is to achieve complete alveolar bone regeneration while keeping inflammation well-controlled. To reach this goal, many single or composite biomaterials that produce antibacterial and osteogenic effects on periodontal tissues have been developed, which are called bifunctional biomaterials. In this review, we summarize recent progress in periodontal bifunctional biomaterials including bioactive agents, guided tissue regeneration/guided bone regeneration (GTR/GBR) membranes, tissue engineering scaffolds and drug delivery systems and provide novel perspectives. In conclusion, composite biomaterials have been greatly developed and they should be chosen with care due to the risk of selection bias and the lack of evaluation of the validity of the included studies.
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S, Saipriya, and Vijay Kumar Chava. "HOST PROTEASE INHIBITION BY SPECIFIC PATHOGENS IN PERIODONTAL DISEASE." International Journal of Research -GRANTHAALAYAH 6, no. 4 (April 30, 2018): 131–37. http://dx.doi.org/10.29121/granthaalayah.v6.i4.2018.1624.
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Proteolytic tissue degradation is a typical phenomenon in chronic inflammatory periodontal disease with the uncontrolled release of host and bacterial derived proteases causing self-digestion and tissue destruction. Antimicrobial proteins and peptides constitute a diverse class of host defense molecules that act early to combat invasion and infection with bacteria and other microorganisms and protease inhibitors forms one of the functional classes of antimicrobial peptides. Plasma protease inhibitors present in gingival crevicular fluid as well as tissues may play a critical role in the protection of periodontal tissues by modulating protease activity, more particularly during active phases. This literature review attempts to highlight the role of host protease inhibitors and their interaction with specific periodontal pathogens in the pathogenesis of periodontal disease.
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Wang, Haiying, Yanmin Wu, Zhengyu Yao, and Cong Wang. "Study of a new nano-hydroxyapatite/basic fibroblast growth factor composite promoting periodontal tissue regeneration." Materials Express 10, no. 11 (November 1, 2020): 1802–7. http://dx.doi.org/10.1166/mex.2020.1738.
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Tissue engineering technology provides a new method for periodontal regeneration. Finding or preparing a suitable scaffold is the key to periodontal tissue engineering. Here, we use nano-hydroxyapatite-modified collagen biomimetic material (nHAC) as the packaging material, and carry fibroblast growth factor (bFGF) for the regeneration and repair of periodontal tissue. Due to its low cytotoxicity and high biocompatibility, nHAC shows unique advantages in the construction of periodontal tissue scaffolds. The nHAC periodontal tissue scaffold material has a dense and porous three-dimensional network structure, has a high loading rate of bFGF, and can firmly lock human periodontal ligament cells (HPDLCs), which is easy for cell growth and attachment. In vivo experiments have shown that, in artificial animal periodontal tissue models, the nHAC-loaded bFGF periodontal scaffold covered by Geistlich Bio-Gide (GBG) membrane is better than the simple GBG membrane and the blank group, the nHAC/bFGF-GBG composite membrane It is beneficial to promote the growth of new alveolar bone and cement formation, and realize the regeneration of periodontal tissue.