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1
Gaspar, Inês de Carvalho. "Relevância da periodontologia na ortodontia." Master's thesis, [s.n.], 2011. http://hdl.handle.net/10284/2404.
Full textAbstract:
Trabalho apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária.Introdução: Nos últimos tempos, o número de pacientes adultos que pretende realizar tratamento ortodôntico tem vindo a aumentar substancialmente. Muitos desses adultos, porém, sofrem de doença periodontal, o que irá condicionar o tratamento ortodôntico. Objectivo: O presente estudo pretendeu avaliar se existem, ou não, diferenças na abordagem terapêutica de pacientes adultos que necessitam de tratamento ortodôntico, entre Médicos Dentistas (MD) que exercem Ortodontia em exclusividade, MD que não exercem Ortodontia em exclusividade e/ou MD que não exercem ortodontia. Material e Métodos: MD que exercem Ortodontia em exclusividade e MD que não exercem Ortodontia em exclusividade e/ou MD que não exercem Ortodontia foram inquiridos. Os inquéritos, constituídos por 13 perguntas de resposta obrigatória, a maioria de múltipla escolha e de resposta rápida, tiveram como principal objectivo avaliar a abordagem dos MD perante as situações enunciadas. Foram enviados por via electrónica em Abril, tendo sido dadas seis semanas para resposta, findas as quais os inquéritos foram retirados da plataforma digital. Resultados: Dos 500 MD abordados apenas 86 reponderam ao inquérito. Destes, apenas 11 referiram exercer Ortodontia em exclusividade, tendo todos frequentado pós-graduação na área especificada. No que concerne à avaliação periodontal relativamente ao exercício ou não de ortodontia em regime de exclusividade, verificou-se que todos os MD consideram que o tratamento periodontal prévio ao tratamento ortodôntico tem relevância no resultado final; dos MD com prática exclusiva em Ortodontia, 82% encaminham os seus pacientes adultos ao periodontologista, em oposição aos 52% dos MD que não exercem Ortodontia em exclusividade e/ ou MD que não exercem Ortodontia; a maioria dos MD considera que em pacientes periodontais que estão a realizar tratamento ortodôntico, a frequência das consultas de tratamento de suporte periodontal deve ser de 3 em 3 meses. Conclusões: Apesar de as diferenças não serem estatisticamente significativas a abordagem terapêutica de MD que exercem Ortodontia em exclusividade, MD que não exercem Ortodontia em exclusividade e/ou MD que não exercem ortodontia é distinta. Introduction: On the past few years, the number of adult patients pretending orthodontic treatment has been growing. However, many of those patients have active periodontal disease which will make the treatment impossible. Purpose: This review pretends to evaluate if there are any differences on the clinical approach of periodontal disease on adults who require orthodontic treatment, between Dentists who exclusively practice orthodontics and Dentist who don’t practice orthodontics exclusively. Methods: An inquiry was made to Dentists who exclusively practice orthodontics and Dentist who don’t. The inquiries had 13 questions; the majority of them had multiple choices to chose from and some quick answer questions. The main goal was to evaluate the clinical approach of the dentist to the given situations. All inquiries were sent electronically on April and a period of 6 weeks was given for receiving all the responses. Results: From the 500 inquiries sent, 86 clinicians have responded. From this number, only 11 have reported to exclusively exercise Orthodontics at their clinics, all having attended graduate school in the specified area. Regarding to periodontal evaluation between those who exclusively practice Orthodontics and general dentists, it was found that all dentists consider that periodontal treatment prior to orthodontic treatment has relevance in the final result; from those with exclusive practice of Orthodontics, 82% refer their patients to the Periodontologist, while only 52% of the general dentists do so. The majority of dentists believe that periodontal patients who are undergoing orthodontic treatment must attend periodontal support every 3 months. Conclusion: Although the differences were not statistically significant, therapeutic approaches between orthodontic specialists and general dentists is distinct.
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Gobbato, Luca. "Patients’ morbidity and root coverage outcomes by means of coronally advanced flap and the application of sub-eptithelial connective tissue graft with different surgical procedures." Doctoral thesis, Universitat Internacional de Catalunya, 2016. http://hdl.handle.net/10803/387224.
Full textAbstract:
Numerous surgical periodontal techniques have been introduced, over the years, to correct
labial, gingival recessions defects. Aesthetic concerns are usually the reason to perform
these procedures. The aim of this project was to evaluate by means of an image analysis
system the efficacy of two different surgical procedures with and without the use of a subepithelial
connective tissue graft for the treatment of miller class one and two maxillary
gingival recession. Therefore the aim of the first study was to compare the effectiveness of
root coverage with coronally advanced flap alone versus a connective tissue graft used in
combination with a coronally advanced flap in the treatment of single gingival recessions
by analyzing the data with an open source image-processing program.
The result of this study showed better outcomes in terms of recession reduction after 12
months when the coronally advanced flap was combined with the connective tissue graft.
Adjunctive application of a connective tissue graft under a coronally advanced flap
increased the probability of achieving complete root coverage in maxillary Miller Class I
and II defects (61.5% vs. 83.3%, p=0.38). The second article is a case demonstration of the
benefit attained using the CAF+CTG in order to meet the patient’s needs and fulfilling the
clinical outcomes.
More recently, several authors have proposed the application of a connective tissue graft
using a tunneling technique, which has recently gained popularity in periodontal
mucogingival therapy. However, there is scarce data available regarding postoperative
patient-centered outcomes after tunneling technique as compared to other surgical
procedures for the treatment of gingival recession. The aim of the second randomizedcontrolled
clinical trial was to compare the patient morbidity and root coverage outcomes
6
of a connective tissue graft used in combination with a coronally advanced flap or tunneling
technique.
Fifty patients completed the study. Healing was uneventful for all test and control patients.
The connective tissue graft used in combination with a coronally advanced flap group
reported less pain or discomfort in all four sections of the questionnaire: Pain experienced
within the mouth as a whole, pain experienced throughout the day, pain experienced at
night and edema experienced after the surgery (p=0.002, p=0.001, p=0.001 and p=0,001,
respectively). Both treatments showed clinical efficacy in terms of root coverage as no
differences per groups were observed in percentage of root coverage (87% vs. 85%, p=704)
or patients with complete root coverage (60% vs. 52%, p=0.569).
The tunneling technique is associated with a greater incidence of pain and discomfort
compared to the connective tissue graft used in combination with a coronally advanced flap
in early postoperative periods, as well as longer chair time. Both treatments showed similar
clinical efficacy in terms of root coverage.
The results of this study may influence the surgeon’s choice on which root coverage
procedure perform considering the need of more chair time and more pain killer assumption
with the tunnel technique.
3
Paniz, Gianluca. "Prospective Clinical Evaluation of Periodontal Response to Different Prosthetic Margin Design." Doctoral thesis, Universitat Internacional de Catalunya, 2016. http://hdl.handle.net/10803/387222.
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Sub-gingival margin placement is sometimes required due to different
reasons and is often associated with adverse periodontal reactions. The
purpose of this study was to determine if a single restoration with subgingival
margin on a tooth, in the maxillary anterior zone, would affect its
periodontal soft tissue parameters, and whether or not a deep chamfer
preparation has a different influence in the periodontium when compared to a
feather edge preparation.
Plaque and gingival indexes, periodontal probing depth, bleeding on probing
and patient’s biotype were registered. 106 teeth were prepared with a deep
chamfer, while 94 were prepared with a feather edge finishing line. Six and
twelve month after the restorations delivery the same parameters were
evaluated. Repeated measure one-way analysis of variance (ANOVA )
(α=0.05) was used. At six months the patient
A statistically significant difference between baseline and the 6 and 12-month
follow up is present in regards to plaque index, gingival index and periodontal
probing depth, but no statistically significant difference between chamfer and
feather edge finishing lines. There is a statistically significant difference
between baseline and the 6 and 12-month follow up in regards to bleeding
on probing. Feather edge preparation presents significantly more bleeding on
probing and less gingival recession than the chamfer.
Sub-gingival margins do influence the periodontal soft tissue response.
Statistically significant difference exists between feather edge and chamfer
finishing lines in regards to bleeding on probing and gingival recession. Subgingival
margins should be carefully selected, especially when feather edge
finishing line is utilized.
4
Rodrigues, Eveline Batista. "Esquema de auxílio ao diagnóstico de reabsorção óssea periodontal através de subtração digital de radiografias odontológicas." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/18/18133/tde-27112006-082102/.
Full textAbstract:
A radiografia é uma das ferramentas primárias de auxílio ao diagnóstico e monitoração do tratamento das doenças periodontais. Porém, a análise subjetiva dessas radiografias feita pelo dentista só consegue identificar lesões quando o quadro clínico apresenta perda acima de 30% do conteúdo mineral do osso, levando um sério desafio ao exercício da odontologia. Em muitas situações clínicas, o dentista também precisa ser capaz de quantificar o tamanho de uma lesão para determinar a taxa de progressão ou cura da doença. A técnica de subtração digital de radiografias provê a detecção de mudanças ósseas sutis, de cerca de 5%, levando ao diagnóstico precoce da doença e aumentando assim o sucesso de seu tratamento. Desta forma, o esquema de auxílio ao diagnóstico de reabsorção óssea periodontal através de subtração digital de radiografias odontológicas proposto no presente trabalho emprega a técnica de subtração digital de radiografias, onde duas radiografias odontológicas, tiradas em intervalos de tempos planejados, são subtraídas para obter uma nova imagem onde serão visíveis somente estruturas que mudaram de uma imagem em relação à outra. Será gerada uma imagem que auxiliará o dentista a efetuar um diagnóstico precoce e instituir o melhor plano de tratamento, e assim acompanhar a resposta do tratamento a partir de novas imagens subtraídas. Na fase anterior à subtração, é necessário o alinhamento, para garantir que estruturas idênticas em ambas imagens estejam no mesmo local, e evitando que o resultado da subtração seja errôneo. O alinhamento consiste na marcação de 4 pontos em regiões de alto contraste em ambas as imagens para que a imagem subseqüente seja alinhada em translação e em rotação em relação à primeira. Posteriormente, uma técnica de correção de contraste é utilizada para corrigir eventuais diferenças de contraste. A subtração fornecerá três formas de visualização, na imagem subtraída, da área onde ocorreu uma reabsorção ou ganho ósseo. Uma delas é a subtração qualitativa, cujas áreas onde as imagens se mantiveram idênticas são mostradas em preto, e áreas onde ocorreram mudanças, em branco. A segunda é a subtração quantitativa, que gera a imagem subtraída em níveis de cinza, mostrando em tons de cinza uniformes áreas onde as imagens se mantiveram idênticas; em tons de cinza escuros, onde ocorreu reabsorção óssea; e em tons de cinza claros, onde ocorreu ganho ósseo. Além destas duas subtrações, há uma terceira subtração, a subtração quantitativa porcentagem-colorida, que mostrará a porcentagem de reabsorção ou ganho ósseo através de áreas coloridas na imagem. O intervalo de porcentagens poderá ser escolhido pelo dentista e a este intervalo poderá ser atribuída uma cor para visualização. Intervalos de porcentagens negativas indicam reabsorção óssea e intervalos de porcentagens positivas, ganho ósseo. Os testes realizados encontraram um erro médio de 7,5% no resultado da subtração, sendo que deste total, 3,5% é o erro introduzido pelo digitalizador. É importante ressaltar que esta taxa representa o erro não somente do algoritmo desenvolvido, mas também a propagação do erro em todas as etapas do processo, ou seja, aquisição, digitalização, alinhamento e subtração. Portanto, o erro da subtração deduzido do erro do digitalizador é de somente 4,0%.Radiography is one of the primary features to help diagnose and monitor the treatment of periodontal diseases. However, the subjective analysis of these radiographs by the dentist only can identify lesions above 30% of mineral bone loss, leading to a serious challenge for the practice of odontology. In many clinical situations, the dentist needs to quantify the size of a lesion to determine the rate of progression or healing the disease. The digital subtraction radiography technique provides the detection of subtle bone changes, i.e., changes of around 5%, leading to an early diagnosis and enlarging the success of its treatment. The aided diagnosis scheme for periodontal bone resorption through odontological digital subtraction radiography proposed in this work employees the digital subtraction radiography technique, where two odontologic radiographs taken at intervals of planned times are subtracted to obtain a new image where only structures that have been changed from one image to the other will be visible. It will generate an image to help the dentist make an early diagnosis and establish the best treatment plan, besides accompanying the treatments response starting from new subtracted images. In the stage previous to the subtraction, the lining up is necessary to assure that identical structures on both images are in the same place, avoiding an erroneous result of the subtraction. It consists in marking 4 points in places with high contrast on both images for the subsequent image to be first lined up in translation and then in rotation in relation to the first one. Then, a contrast correction technique is used to correct possible contrast differences. The subtraction will provide three ways of visualization in the subtracted image of the area where a bone resorption or gain occurred. One of them is the qualitative subtraction, where areas kept identical are showed in black and areas where changes occurred are showed white. The second is the quantitative subtraction, which generates a subtracted image in gray levels, showing in uniform gray levels the areas where the images remained identical, in dark gray levels the areas where there was bone resorption and in light gray levels the area with bone gain. The third subtraction is called colored-percentage quantitative subtraction, which shows the percentage of bone resorption or gain through colored areas on the radiograph. The intervals of percentage can be chosen by the dentist and he/she can attribute a color for visualization to this interval. Negative percentage intervals indicate bone resorption and positive percentage intervals correspond to bone gain. The tests performed found a mean error of 7.5% in the result of the subtraction, of which 3.5% correspond to the error introduced by the digitalizer. It is important to stress that this rate represents the error not only for the algorithm developed, but the spreading of the error to all process stages, such as acquisition, digitalization, lining up and subtraction. Therefore, the subtraction error deduced from the digitalizer error is only 4,0%.
5
Conocimiento, Dirección de Gestión del. "Journal of Periodontology." Wiley, 2004. http://hdl.handle.net/10757/655342.
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Parihar, Anuj Singh [Verfasser]. "Host Modulation in Periodontology / Anuj Singh Parihar." Hamburg : Anchor Academic Publishing, 2015. http://d-nb.info/1109992548/34.
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Conocimiento, Dirección de Gestión del. "Guía de acceso para Journal of Periodontology." Wiley, 2021. http://hdl.handle.net/10757/655342.
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Hegde, Rachana Ashok. "Variation in Treatment Decisions Among AAP-Certified Specialists in Periodontology." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1403890550.
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Hodge, Penelope Jane. "Clinical and genetic analysis of early onset periodontitis." Thesis, University of Glasgow, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301834.
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Kennett, Craig Nader. "Comparative histochemical, immunocytochemical and biochemical studies of proteases and their inhibitors in human gingival tissue and crevicular fluid." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336540.
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Hasan, Fadi K. "Characterization of Leukocyte-Platelet Rich Fibrin, a Novel Biomaterial." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3749.
Full textAbstract:
Autologous platelet concentrates represent promising innovative tools in the field of regenerative medicine and are successfully used in oral surgery. Several commercial systems exist that generate various forms of platelet concentrates including Platelet-rich plasma (PRP) and Platelet-rich fibrin (PRF). The alpha- granules of entrapped platelets release a variety of peptide growth factors that promotes healing. Usually PRP is a suspension that can be injected into the site of injury or used as a gel with the addition of thrombin (PRP-gel). In contrast Choukroun’s L-PRF is a dense fibrin based biomaterial enriched with platelets and growth factors. The physical state of these natural biomaterials especially L-PRF permits manual handling and suturing onto the tissue bead to improve healing. However, our knowledge about the mechanical characteristic of L-PRF is quite limited and a good understanding of material properties will enable expansion of current clinical applications. This study demonstrates the techniques to identify L-PRF’s mechanical properties (uniaxial tensile testing and suture retention strength); morphology (scanning electron microscope); biological stability and cytocompatibility.
12
Abdalla, Mozn. "An assessment of the factors affecting the efficacy of periodontal treatment carried out by postgraduate periodontology students." University of Western Cape, 2020. http://hdl.handle.net/11394/7524.
Full textAbstract:
Magister Chirurgiae Dentium (MChD)Periodontal disease is one of the most common diseases worldwide. Periodontal treatment aims to prevent disease progression and restore functional and aesthetic dentition. The purpose of studying periodontal treatment outcome is to assess treatment efficacy. Treatment outcome of periodontal disease is affected by multiple patient-related factors, the type of treatment provided, and the expertise of the clinician.
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Morgan, Clare Louise. "The role of TGF β in drug-induced gingival overgrowth." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341770.
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Primm, Jason Todd. "Differential stimulation of monocytes to secrete secretory leukocyte protease inhibitor by lipopolysaccharide of periodontal pathogens." View the abstract Download the full-text PDF version, 2009. http://etd.utmem.edu/ABSTRACTS/2009-029-Primm-index.htm.
Full textAbstract:
Thesis (M.S. )--University of Tennessee Health Science Center, 2009.Title from title page screen (viewed on September 19, 2009). Research advisor: Jegdish Babu Ph.D. Document formatted into pages (x,36 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 32-36).
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Pieri, Alexandra Paula. "Avaliação in vitro da rugosidade da superfície radicular após instrumentação com aparelho de ultrassom piezoelétrico, utilizando diferentes substâncias irrigadoras." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/287905.
Full textAbstract:
Orientador: Márcio Zaffalon CasatiDissertação (mestrado) - Universidade Estadual de Campinas. Faculdade de Odontologia de Piracicaba
Made available in DSpace on 2018-08-16T08:30:39Z (GMT). No. of bitstreams: 1 Pieri_AlexandraPaula_M.pdf: 2282598 bytes, checksum: 7fecd7736954b300b66152ae7095fe29 (MD5) Previous issue date: 2010
Resumo: A topografia da superfície radicular é um fator importante para a manutenção da saúde dos tecidos periodontais, e a raspagem para remoção de biofilme promove alterações nessa superfície. O objetivo do presente estudo foi avaliar, por meio da análise rugosimétrica e em microscopia eletrônica de varredura, a rugosidade radicular provocada pela instrumentação periodontal com aparelho ultra-sônico piezoelétrico, utilizando diferentes substâncias irrigadoras, e comparar com o uso de cureta e de ultrassom magnetoestritivo. Para isso, foram selecionados 60 pré-molares humanos extraídos por motivos ortodônticos, que foram lavados em água corrente e acondicionados em recipientes com formol a 10%. Os dentes foram divididos aleatoriamente em 06 grupos experimentais (n=10 cada): Grupo 01: grupo controle, sem instrumentação; Gupo 02: instrumentados com curetas Gracey 5/6; Gupo 03: com aparelho ultra-sônico magnetoestritivo; Gupo 04: com aparelho ultra-sônico piezoelétrico associado ao fluido abrasivo; Grupo 05: com aparelho ultra-sônico piezoelétrico associado ao fluido polidor; Grupo 06: com aparelho ultra-sônico piezoelétrico associado aos fluidos abrasivo e polidor na seqüência. Após o tratamento das superfícies, foram realizadas, com Rugosímetro, três leituras paralelas e três perpendiculares ao sentido da raspagem para determinar os índices Ra e Rz de Rugosidade Superficial Média. Além disso, foram realizadas leituras com aumento de 50 e 250 vezes em Microscopia Eletrônica de Varredura (MEV). Para a avaliação estatística foi utilizada análise de variância (ANOVA) e teste Tukey, com nível de significância de 5%. Foi observado aumento da rugosidade independentemente do instrumento utilizado, ao comparar as superfícies tratadas com as do grupo controle (p<0,05). A instrumentação com o sistema piezoelétrico associado ao fluido polidor proporcionou as superfícies menos rugosas; o ultrassom magnetoestritivo produziu a maior rugosidade superficial entre os grupos estudados (p<0,05). Dentre os grupos do sistema piezoelétrico, o que utilizou o fluido abrasivo proporcionou os valores mais altos de rugosidade. O uso associado dos fluidos abrasivo e polidor foi semelhante ao uso da cureta, e produziu superfícies com rugosidade significativamente maior que a do uso do piezoelétrico com fluido polidor. Portanto, diante dos resultados obtidos, pode-se concluir que o uso das diferentes substâncias irrigadoras na instrumentação com ultrassom piezoelétrico influencia na rugosidade radicular. O fluido abrasivo incrementa a rugosidade superficial, mas ainda assim, o aparelho magnetoestritivo deixa as superfícies mais rugosas. A técnica que utilizou o ultrassom piezoelétrico com fluido polidor foi a que resultou nas superfícies menos rugosas
Abstract: The topography of the root surface is an important factor for maintaining periodontal tissues healthy, and scaling for biofilm removal promotes alterations in that surface. The aim of this study was to evaluate with rugosimeter and SEM examination, root roughness after instrumentation with a piezoelectric ultrasonic device using different irrigation substances, comparing with curettes and magnetostrictive ultrasonic device. Sixty human pre-molars that had been extracted for orthodontic reasons were washed in running water and kept in 10% formaldehyde until the experiment was carried. The teeth were randomly divided into 6 experimental groups (n=10, each): Group 01: control group, no instrumentation; Group 02: instrumentation with Gracey 5/6curettes; Group 03: instrumentation with a magnetostrictive ultrasonic device, Group 04: piezoelectric ultrasonic device associated to abrasive fluid, Group 05: piezoelectric ultrasonic device associated to polishing fluid, and Group 06: piezoelectric ultrasonic device associated to abrasive fluid followed by polishing fluid. After root surface treatments, three readings were carried with a rugosimeter, both parallel and perpendicularly to the direction of the scaling, in order to determine Ra and Rz rates of average surface roughness. In addition, readings with 50x and 250x magnification on Scanning Electron Microscope (SEM) were done. For statistical analysis, ANOVA and Tukey's test were used, with significance level at 5%. An increase in roughness was observed, regardless of the instrument used, when comparing treated surfaces to those in control group (p<0,05). Instrumentation with piezoelectric system associated to polishing fluid provided less rough surfaces; magnetostrictive device caused the highest roughness among the studied groups (p<0.05). Among the groups using piezoelectric system, the one using abrasive fluid caused the highest values in roughness. The combined use of abrasive and polishing fluids subsequently was similar to the curette, and produced surfaces with roughness significantly higher than piezoelectric system with polishing fluid. With the obtained results, it can be concluded that the use of different irrigation substances during instrumentation with piezoelectric ultrasonic device can influence on root surface roughness. The abrasive fluid increments surface roughness, but the magnetostrictive device is still less aggressive that. The technique that used piezoelectric ultrasound with polishing fluid resulted in less rough surfaces
Mestrado
Periodontia
Mestre em Clínica Odontológica
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Malboubi, Saeid. "In vitro actions of platelet rich plasma and resolvin E1 on osteoblast and osteoclast activity." Thesis, Boston University, 2009. https://hdl.handle.net/2144/35619.
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Thesis (MSD) --Boston University, Henry M. Goldman School of Dental Medicine, 2009 (Department of Periodontology and Oral Biology).Includes bibliographic references: leaves 52-59.
Platelet-rich plasma (PRP) is a concentrated gel of platelets that contains several growth factors. Growth factors have been recognized as the part of PRP that play role in regeneration of the bone. It is not clear how these growth factors in PRP affect the bone regeneration. Resolvin El (RvEl; 5S,12R,18R-trihydroxyeicosapentaenoic acid) is an pro-resolving lipid mediator derived from omega-3 fatty acid eicosapentaenoic acid and shown to have potent effects on the resolution of inflammation. The purpose of this study was to analyze the action of PRP and RVEl on the proliferation and behavior of osteoblasts and osteoclasts in vitro. PRP was prepared from 14 healthy donors. Osteoblast cultures were from a cell line (Saos2) of osteosarcoma cells. Osteoclasts were differentiated from primary human peripheral blood monocytes. Osteoclastic morphology was studied and activity was analyzed via resorption on dentin discs using SEM. PRP and RVE 1 were added at different doses and time-points. Osteoblast function was analyzed by osteocalcin expression and release. Osteoclast activity was assessed by resorption and cathepsin K expression. PRP and RvEl comparably increased the osteoblastic activity and suppressed the osteoclast differentiation and function. These results suggest that multiple tools are available to reverse the inflammation and restore the lost bone architecture as a result of periodontal disease.
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Wayele, Ban, and Rashida Nezami. "Förekomst av parodontit och karies hos typ 2 – diabetiker." Thesis, Högskolan Kristianstad, Sektionen för hälsa och samhälle, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-9942.
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The aim of this study was to describe the prevalence of gingivitis, periodontitis and dental caries in individuals with type 2 – diabetes. The study was conducted in a form of a general literature review with the restricted to the following conditions: human studies, English, and articles published between 2007 - 2012. Articles lacking a control group were excluded. The data were collected through searches of the medical database PubMed. A compilation of 11 scientific articles was examined. In individuals with diabetes mellitus type 2, the presence of gingivitis was identified in 3 articles, periodontitis in 10, and dental caries in 3 articles. The 3 articles that showed presence of gingivitis demonstrated that individuals with type 2 – diabetes had a higher prevalence of gingivitis compared to non-diabetic individuals. A higher prevalence of periodontitis in individuals with type 2 – diabetes mellitus was found in 10/10 publications. Theses studies demonstrated in individuals with type 2 – a significantly higher incidence of deep pocket depths, attachment loss, recession defects and with higher plaque and gingival index scores. The three articles that showed the presence of dental caries also demonstrated a higher prevalence of dental caries in individuals with type 2 – diabetes mellitus. The articles included in the literature study showed statistically significant higher prevalence of gingivitis, periodontitis, and dental caries in individuals with type 2 – diabetes mellitus than in individuals without a diagnosis of diabetes. Keywords: Type 2 – Diabetes, Gingivitis, Periodontitis and Dental Caries
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Liu, Xinyan. "Molecular characterization of Porphyromonas gingivalis heme utilization systems--role of HmuR and gingipains in heme utilization." Thesis, Boston University, 2005. https://hdl.handle.net/2144/37164.
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Thesis (Ph.D.)--Boston University, Henry M. Goldman School of Dental Medicine.PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.
Porphyromonas gingivalis , a Gram-negative anaerobic pathogen of periodontal diseases, requires iron in the form of heme (a term used to denote either the ferrous or ferric form of iron protoporphyrin IX) for growth. P. gingivalis is capable of utilizing a broad range of heme-containing compounds such as hemoglobin, hemoglobin-bound haptoglobin, hemin-bound hemopexin and hemin-saturated serum. Heme and hemoglobin utilization in P. gingivalis requires the participation of an outer membrane protein HmuR (heme utilization receptor), as well as cysteine proteinase gingipains (Lysine-specific gingipain Kgp and Arginine specific gingipains Rgps). However, the specific mechanisms utilized for heme acquisition are poorly understood. In this study, the role of HmuR in heme utilization was characterized in both E. coli and P. gingivalis . Molecular interaction between HmuR and hemin/hemoproteins was also characterized by construction and analysis of HmuR site-directed mutants. Our results support the direct role of HmuR in heme utilization. Hemoprotein utilization in P. gingivalis requires the participation of HmuR conserved residues. The HmuR residues 95 and 434, as well as the NPDL motif, seem to be involved in whole cell binding of hemoproteins; while the YRAP motif does not. All these residues seem essential for serum hemoprotein utilization. Analyses of HmuR by homology modeling provided a structural basis for functional analysis and supported the results from mutagenesis studies. In addition, expression of the hmuR, kgp and rgpA genes in response to different heme sources was also examined. We found that expression of the hmuR gene was negatively regulated by heme, while expression of the kgp and rgpA genes seemed to be regulated by growth phase. These different regulatory mechanisms, as well as the coordinate expression between HmuR and gingipains, indicate a complementary regulation mechanism for optimal heme utilization in P. gingivalis.
2031-01-01
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Doshi, Anuja. "Topical Phenytoin Effects on Palatal Wound Healing." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1563487879484746.
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White, John H. "The Periodontal Specialty: A Survey Regarding Our Future." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5288.
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Purpose: To determine the characteristics influencing periodontal practices in Virginia and report on the anticipated changes in practice.
Methods: A REDCap survey was emailed to Virginia based American Academy of Periodontology (AAP) members assessing personal and practice demographics, trends in dental treatment and practice models, and how periodontists will adjust to account for these trends.
Results: The response rate was 31% (n=46). Respondents report greater referrals from more experienced general practitioners (GPs). Student debt was associated with age. Respondents ranked biologic advances, treatment of peri-implantitis, digital dentistry, development of corporate and group practice models, and GPs incorporating more periodontal services in their practices as most likely to impact periodontal practices. The most reported periodontal practice adjustments included expansion of existing services, increasing the number of periodontists in the practice, and joining with other specialists or GPs to create group practices.
Conclusions: Periodontists perceive the need to expand services, increase number of providers in their practices or create group practice models as future practice adjustments.
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San, Khin MiMi. "tRNA Profiling of Mesenchymal Stem Cell Exosome." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5638.
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Background: Exosomes have great potential in regenerative medicine through the
transfer of their bioactive cargos, such as RNA. tRF RNA and tiRNA are tRNAderived
non-coding RNA. Here, we sought to identify the tRF/tiRNA profile in human
mesenchymal stem cell (hMSC) exosomes. Methods: Bone marrow hMSCs were
cultured with/without osteogenic differentiation medium and exosomes were
harvested. RNA was extracted from: 1) control cells (Cell-NT); 2) control exosomes
(EXO-NT); 3) differentiated cells (Cell-OM); 4) exosomes produced by differentiated
cells (EXO-OM). RNA was sequenced to profile the small RNA with a focus on
tRF/tiRNA. Results: tRF/tiRNA was highly enriched in hMSC exosomes. Less
diversity was seen in the tRF/tiRNA profile in exosomes than that in parent cells.
Selective tRF/tiRNA were packed into MSC exosomes and their profile is dependent
on the cell maturation status. Conclusions: Our results suggest that tRF/tiRNA may
play a role in mediating the function of exosomes in tissue regeneration.
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Reichert, Amy. "The Effect of Biologic Materials and Oral Steroids on Radiographic and Clinical Outcomes of Horizontal Alveolar Ridge Augmentation." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5718.
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The purpose of this study was to investigate if the addition of biologic materials and/or oral steroids would affect horizontal bone gain, or the bone density of the grafted bone in horizontal alveolar ridge augmentations. A retrospective chart review was completed to assess the clinical and radiographic outcomes of 53 ridge augmentation patients. An average bone gain of 3.6mm of width was found in our study based on radiographic analysis. There were no statistically significant differences found in the linear bone gain with the addition of biologic materials and steroids. A marginally statistically significant difference was found in the bone density when biologics were added (p-value=0.0653). No statistically significant difference found in the bone density with the addition of oral steroids. The use of tenting screws and resorbable occlusive membranes and a combination of allograft and xenograft bone materials provides significant clinical and radiographic dimensional changes in alveolar ridge width.
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Glazier, Thomas F., Thomas C. Waldrop, John C. Gunsolley, and Robert Sabatini. "The Role of Leukocyte-Platelet Rich Fibrin in Human Alveolar Ridge Preservation: A Randomized Clinical Trial." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3735.
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PURPOSE: The aim of this study is to examine the healing of intact extraction sockets grafted with leukocyte-platelet rich fibrin (L-PRF) as compared to sockets grafted with freeze-dried bone allograft (FDBA) and a resorbable collagen barrier membrane (RCM).
METHODS: This prospective randomized, examiner blinded pilot study included 17 subjects randomized to two treatment groups. Serum total cholesterol, low density lipoprotein (LDL), 25-hydroxyvitamin-D3, and platelet counts were determined preoperatively in all subjects. The experimental arm consisted of 8 posterior tooth-bounded intact extraction sites receiving L-PRF plugs. The control group consisted of 9 posterior tooth-bounded intact extraction sites receiving FDBA and RCM. An acrylic stent was fabricated to take duplicate clinical and CBCT measurements immediately post-extraction and at time of implant placement. A repeat-measures analysis of variance was utilized for statistical analysis.
RESULTS: The study failed to detect a clinical or radiographic difference between treatment groups in horizontal or vertical ridge dimension changes. Serum cholesterol, LDL, 25-hydroxyvitamin-D3, and buccal plate thickness had a non-significant effect on outcome measurements, although there was a high prevalence of hyperlidpidemia and hypovitaminosis in the study population.
CONCLUSIONS: The alveolar ridge dimension changes in intact posterior extraction sockets may be similar when either L-PRF or FDBA and RCM are utilized as socket grafting material. Although there was a high prevalence of high cholesterol and low 25-hydroxyvitamin-D3 levels in the population, this study failed to detect a significant correlation between preoperative serum levels and postoperative ridge dimension changes.
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Salame, Joumana. "EVALUATION OF TWO ORAL PROBIOTIC PRODUCTS FOR MICROBIAL VIABILITY AND IN VITRO INHIBITION OF SELECTED PERIODONTAL BACTERIAL PATHOGENS." Master's thesis, Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/147512.
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Oral BiologyM.S.
Objectives: One potential impact of oral probiotic products involves use of known bacterial antagonisms to alter the ecologic environment in periodontal pockets from one inhabited by pathogenic dental plaque microorganisms to one more favorable to colonization by non-pathogenic species (bacterial replacement). Until recently, the ability to introduce such beneficial effector bacteria into the oral cavity of periodontitis patients has been limited by the lack of specifically-formulated available commercial probiotic products. PerioBalance (Sunstar GUM), with two strains of the gram-positive, aerobic species Lactobacillus reuteri, and EvoraPlus (Oragenics), with freeze-dried strains of the gram-positive, aerobic species Streptococcus oralis, Streptococcus uberis, and Streptococcus rattus, are two recently-introduced commercial oral probiotic products proposed to have beneficial effects against periodontal disease. However, it is not known if the microbial species contained in these two oral probiotics are viable after the manufacturing process, and have the capability to exert inhibitory effects against putative periodontal bacterial pathogens when reconstituted in the oral cavity. Thus, the objective of the present study was to determine whether PerioBalance lactobacilli and EvoraPlus streptococci are viable upon product use, and possess in vitro inhibitory effects against fresh clinical strains of the putative periodontal bacterial pathogens, Tannerella forsythia and Prevotella intermedia/nigrescens, in the presence of anaerobic growth conditions. Methods: Commercial lots of PerioBalanceÒ and EvoraPlusÒ tablets were aseptically removed from the product packaging with sterile forceps, dissolved into Möller’s VMG I anaerobic dispersion solution, plated onto pre-reduced, enriched Brucella blood agar, and subjected to overnight anaerobic incubation at 35ºC in a culture cabinet containing 85% N2-10% H2-5% CO2, and to overnight aerobic incubation in a 5% CO2-95% air atmosphere. All culture plates were then visually examined under magnification for microbial colony growth. In vitro solid media competition assays were used to assess the in vitro inhibition capability of the two oral probiotics against T. forsythia and P. intermedia/nigrescens. Pioneer PerioBalance lactobacilli and EvoraPlus streptococci colonies were first grown on enriched Brucella blood agar media, followed by secondary spotting of T. forsythia and P. intermedia/nigrescens isolates immediately next to the established pioneer EvoraPlus and PerioBalanceÒ bacterial colonies such that they almost touched each other. After an additional overnight anaerobic incubation period, growth inhibition of the putative periodontal bacterial pathogens by the pioneer PerioBalance and EvoraPlus colonies was noted as the visual presence without magnification of a proximal zone of inhibition at the intersection of the pioneer colonies and the T. forsythia and P. intermedia/nigrescens colonies. Results: PerioBalance lactobacilli grew readily and in abundance in vitro on anerobically and anaerobically-incubated EBBA, with no other colony types or contaminating organisms. In contrast, EvoraPlus product samples purchased over-the-counter from drug stores in Maryland and Pennsylvania failed to exhibit any in vitro microbial growth under anaerobic and aerobic incubation conditions, with only EvoraPlus tablets obtained directly from the manufacturer yielding in vitro streptococcal growth. No in vitro inhibition was noted under anaerobic conditions of established PerioBalance lactobacilli and EvoraPlus streptococci pioneer colonies against subsequent growth of clinical isolates of T. forsythia and P. intermedia/nigrescens, with no zone of inhibition developing between their colonies and the immediately-adjacent established oral probiotic pioneer colonies. Conclusions: The two commercial oral probiotics evaluated varied considerably in the viability of their microbial constituents, with abundant growth of PerioBalance lactobacilli found in over-the-counter product material, and the lack of any EvoraPlus streptococci growth in product tablets obtained from sources other than directly from the manufacturer. Both oral probiotic products failed in vitro, in solid media competition assays, to inhibit growth of fresh clinical isolates the putative periodontal bacterial pathogens T. forsythia and P. intermedia/nigrescens under anaerobic growth conditions. These findings question the potential effectiveness of the two oral probiotic products to alter the subgingival ecology in periodontal pockets when anaerobic environmental conditions are present. Additional research is needed to assess the inhibitory potential of PerioBalance lactobacilli and EvoraPlus streptococci against additional isolates of subgingival bacterial species, and in circumstances where microaerophilic or aerobic environmental conditions are found.
Temple University--Theses
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Camacho, Diego A. DMD. "Trabecular Bone Microarchitecture in Association with Systemic and Local Factors as Potential Predictors of Implant Failure." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4168.
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Clinicians have described the success rates of dental implants. The use of implants is projected to increase in the future. With a 5-10% failure rate, it is unclear the exact factors that are associated with implant failures. To improve upon these success rates, it is critical to understand parameters associated with implant failure including: periodontitis, peri-implantitis, systemic diseases, site preparation, dental history of the implant site, bone quality, materials, occlusion, and treatment timelines. While bone quality is associated with failure, objective measures to assess bone quality and characteristics are scarce. Therefore, the aim of this study is to determine whether possible comorbidities, associated dental parameters, and measurable bone quality are possible predictors of implant failure.
In this study, we utilized the electronic health record system axiUm® to retrospectively investigate non-failed (NF) and failed (F) dental implants from a patient cohort with 149 implants placed between 2012-2015 at Virginia Commonwealth University School of Dentistry. A chart review was conducted extracting information on age, gender, systemic diseases, smoking, occlusal trauma, parafunction, bone grafting history, treatment timelines, implant site/type/placement protocol, infection, torque at placement, bone quality and microarchitecture assessed by the novel, innovative technology: trabecular bone score (TBS).
A total of 149 implants, 46 failures and 105 non-failed controls, were selected based on similar implant sites. Preliminary data obtained from analysis suggests that average time from implant placement to failure was 6.6 months (0.55 years). Parafunction habit (p=0.0202) and increased number of implants (p=0.0478) were found to be associated with increased implant failure.
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Selaci, Florinda, and Marinela Moldovan. "Förekomst av karies och parodontit hos vuxna personer med övervikt/fetma." Thesis, Högskolan Kristianstad, Sektionen för hälsa och samhälle, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-9506.
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Övervikt och fetma är ett stort hälsoproblem världen över. År 2008 var cirka 1,5 miljarder vuxna i världen överviktiga. Syftet med litteraturstudien var att undersöka om det finns en ökad förekomst av karies och parodontit hos vuxna personer med övervikt/fetma. Urvalet begränsades till vuxna som var 19 år eller äldre. Studien utfördes i form av en allmän litteraturstudie och materialet samlades in genom sökning i databaserna Pub Med och Science Direkt samt genom manuell sökning. Resultaten sammanställdes utifrån 14 vetenskapliga artiklar. Två vetenskapliga artiklar visade en ökad förekomst av karies hos personer med övervikt/fetma i jämförelse med personer som var normalviktiga. De andra artiklarna (n=2) som berörde karies hittade inget direkt samband mellan ökad kariesförekomst och övervikt/fetma. En ökad förekomst av parodontit hittades hos personer med övervikt/fetma i flera studier (n=4) vid jämförelse med normalviktiga deltagare. De resterande studierna (n=6) visade ett samband mellan förekomst av parodontit och personer med övervikt/fetma. Det tycks finnas en ökad förekomst av parodontit hos personer med övervikt/fetma då olika socioekonomiska faktorer eller andra förhållanden har betydelse. De fåtal artiklar som undersöktes visar att faktorer som kostvanor, saliv och munhygien är avgörande vid kariesförekomst.Overweight and obesity are a huge health problem worldwide. Year 2008 it was about 1,5 billion adults that were overweight. The aim of this study was to investigate if there is an increased occurrence of dental caries and periodontal disease in adults with overweight/obesity. The study was limited to adults that were nineteen years old and above. The material was collected from the databases PubMed and Science Direct and a manual search. These results are based on fourteen scientific articles. Two scientific articles showed an increased occurrence of dental caries on persons with overweight/obesity compared with people who were normal weighted. The other studies (n=2) did not found a direct correlation between increased caries and overweight/obesity. The presence of periodontal disease in individuals with overweight/obesity was found to be increased significantly in several studies (n=4) compared to participants with normal weight. The other studies (n=6) showed a relation between occurrence of periodontitis and overweight/obesity. There seems to be an increased occurence of periodontitis in persons with overweight/obesity as several socio- economic factors or other conditions affect. The few scientific articles that were examined show that factors such as diet, saliva and oral hygiene are important in caries occurrence
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Azarnoush, Kian. "The Effects of Amixicile on Sub-gingival Biofilm Cultured from Humans." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5349.
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Periodontitis is an inflammatory disease of the oral cavity induced by anaerobic bacteria, that remains to be the primary cause of tooth loss in adults worldwide. Finding an anti-microbial therapeutic to selectively target periodontal pathogens has proven to be difficult, and current treatment modalities only provide a transient benefit. Amixicile is a non-toxic, readily bioavailable novel antimicrobial that targets strict anaerobes through inhibition of the activity of Pyruvate Ferredoxin Oxidoreductase (PFOR), a major enzyme mediating oxidative decarboxylation of pyruvate, a critical step in metabolism. Our study aimed to evaluate the efficacy of amixicile in inhibiting the growth of bacteria harvested from the complex sub-gingival biofilm of patients with chronic periodontitis. We hypothesize that amixicile will selectively inhibit pathogenic anaerobic bacteria collected from patients, with the same efficacy as metronidazole, the current accepted treatment modality.
Plaque samples were harvested from patients with severe chronic periodontitis and cultured under anaerobic conditions. The microbiomes were grown in the presence of amixicile and metronidazole and the growth was compared to that of bacteria grown in the absence of the antimicrobials. Following 24 hour incubation, bacterial DNA was isolated and bacterial quantity was evaluated by quantitative PCR (qPCR) using primers specific for 12 bacterial species: P. gingivalis (Pg), P. intermedia (Pi), F.nucleatum (Fn), S.gordonii (Sg), S. anginosus (Sa), V. atypical (Va), L. acidophilus (La), A.actinomycetemcomitans (Aa), T.denticola (Td), S.mutans (Sm), S.sanguis (Ss), and 16s. Individual qPCR runs were combined to represent an overall average of CT value differences.
Amixicile treatment groups exhibited statistical significant reductions (PP. intermedia, F. nucleatum and Veillonella atypical. When comparing amixicile to metronidazole, amixicile performed with similar efficacy with the largest effect seen for PFOR bacteria. Our conclusion supports amixicile as a potent inhibitor of anaerobic bacteria, and could be a potential new therapeutic antimicrobial in the treatment of periodontal disease
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Mattos, Ana Carolina Lopes. "Osteonecrosis of the jaw in association to bisphosphonates." Thesis, Boston University, 2008. https://hdl.handle.net/2144/41446.
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Thesis (M.A.)--Boston University, 2008.The use of bisphosphonate has become more widespread for the treatment of bone metastasis, multiple myeloma, osteoporosis, Paget's disease and other bone malignancies. Osteonecrosis of the jaw (ONJ) has been recently recognized as a possible complication of the use of bisphosphonate therapy. This study includes a review of the literature on the mechanism of action of bisphosphonate and its potential association to the development of osteonecrosis of the jaw. The inhibitory effects of bisphosphonates on osteoclasts and its antiangiogenic properties have been examined as possible mechanisms to induce osteonecrosis of the jaw. The incidence of ONJ in osteoporosis patients receiving bisphosphonate treatment is <1 in 100,000, and in between 1% and 10% in patients with malignancy (Hess et al., 2008). The results of this study suggest a higher incidence of osteonecrosis of the jaw in patients under long term use of nitrogen containing bisphosphonate. The incidence of bisphosphonate associated ONJ in the first 4 to 12 months of therapy was of 1.5% and it increased to 7.7% after 37 to 48 months [Bamias] Additional risk factors include dental extractions, invasive dental procedures and trauma. It is not yet clear, however, if other drugs that affect bone turnover may induce similar complications. This study suggests an association of bisphosphonates to the development of osteonecrosis of the jaw. There is no evidence that bisphosphonates cause osteonecrosis of the jaw. An evaluation of the published data indicates that more research is necessary to understand the relationship of bisphosphonates and osteonecrosis of the jaw.
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Al-Hotheiry, Mehdi, and David Sun. "Assessment of the gingival biotype at natural teeth." Thesis, Malmö universitet, Odontologiska fakulteten (OD), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-19973.
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BakgrundDen gingivala biotypen utvärderas regelbundet kring egna tänder före och efter kirurgiska ingrepp (t.ex för behandlingsplanering och riskbedömning). Nyligen presenterade Colorvue® biotypprobe (CBP) en ny metod för bedömning av gingivala biotyper i syfte av att möjliggöra en mer detaljerad klassificering av gingivan. Studien syftade till att bedöma det nya sonderingsystemets reproducerbarhet, repeterbarhet och riktighet vid naturliga tänder.MetoderDenna tvärsnittsstudie omfattade 50 deltagare (3 tänder/deltagare) och gingival biotyp bedömdes med 3 metoder vid en centralincisiv, lateralincisiv och hörntand med: 1) med en standard periodontal sond (SPP), 2) med CBP-proberna (CBP1/2/3), och 3) genom visuell bedömning (VA). Den faktiska tjockleken bedömdes genom transgingival sondering med en endodontisk fil. Utvärderingen gjordes av 8 granskare och reproducerbarhet mellan granskare och repeterbarhet inom granskaren utvärderades.ResultatFördelningen av gingivala tjockleken i studiepopulationen är uppdelad i tunn (18%), mellan (29%), tjock (29%) och mycket tjock (24%). Fördelningen av de fyra CBP-kategorierna är tunn (10%), medium (87%), tjock (2%) och mycket tjock (1%). Intervallet av gingivala biotypen bland de 8 granskarna enligt CBP: tunn (1% till 34%), medium (65% till 86%), tjock (0% till 4%) och mycket tjock (0% till 3%). Statistiskt signifikant skillnad i tjocklek av gingivan hittades i elva av fyrtio utvärderingar bland alla examinator och för alla metoder (VA, CBP och SPP). Fem av de signifikanta skillnaderna hittades bland CBP-sonderna, fyra för SPP och två för VA. Varken SPP eller CBP visade en tydlig tillförlitlighet i bedömning av gingivala tjockleken. SPP visade bäst resultat i både reproducerbarhet och repeterbarhet. Överensstämmelsen mellan granskarna med avseende på CBP varierade från måttlig till stor överensstämmelse. Reproducerbarhet bland granskaren varierade från dålig till nästan perfekt överenskommelse.SlutsatserBaserat på reproducerbarhet, repeterbarhet och exakthet, är SPP-sondernas förmåga att klassificera gingival biotyp i 4 kategorier av distinkt tjocklek bättre än CBP och VA.BackgroundThe gingival biotype is regularly assessed around natural teeth before and after surgical procedures (e.g. for treatment planning and risk assessment). Recently, a new set of probes Colorvue® biotype probe (CBP) for gingival biotype assessment has been introduced, with the intention to facilitate a more detailed classification (i.e., 4 categories in total). The study aimed to evaluate the feasibility and reproducibility of this new probe system at natural teeth.MethodsThis cross-sectional study included 50 participants (3 teeth/participant), and gingival biotype was assessed by 3 methods at one maxillary central incisor, lateral incisor and canine with 1) with a standard periodontal probe, 2) with the CBP probes, and 3) by visual judgement. The actual thickness was assessed by transgingival sounding with an endodontic file. The judgements were done by 8 examiners, and inter-examiner reproducibility and intra-examiner repeatability were assessed.ResultsThe distribution of the gingival thickness in the present study population is divided into thin (18%), medium (29%), thick (29%) and very thick (24%). The distribution of the 4 CBP categories are thin (10%), medium (87%), thick (2%) and very thick (1%). The range of gingival biotype among the 8 examinators: thin (1% to 34%), medium (65% to 86%), thick (0% to 4%) and very thick (0% to 3%). A statistically significant difference in gingival thickness was found in eleven out of forty evaluations among all evaluators and for all methods (VA, CBP, and SPP). Five of the significant differences were found among the CBP probes, four for the SPP, and two for the VA. When compared, neither the SPP nor the CBP was clearly more reliability than the other. SPP showed the best results in both inter-examiner reproducibility and intra-examiner repeatability. Inter-examiner reproducibility for the CBP ranged from moderate to substantial agreement. Intra-examiner repeatability varied from poor to almost perfect agreement.ConclusionsBased on the reproducibility, repeatability and accuracy, the SPP method to classify the gingival biotype accurately into 4 categories of distinct thickness performed better than CBP and VA.
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Rastogi, Amal. "Heritability of Autoantibody Levels in a Twin Population." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1854.
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AIM: This study aims to determine what portion of specific autoantibody phenotypes are genetically determined by using a twin model. METHODS: This study specifically examines Anti-Ro(SSA), Anti-La (SSB), Anti-Sn/RNP, Anti-Sm, Anti-Jo-1, Anti-Scl-70, Anti-Tg & Anti-TPO, Anti-dsDNA, Anti-PS, and Anti-cardiolipin antibodies for their heritability. This study examined 104 same-sex adult twins (66 monozygous, 38 dizygous) for the above mentioned autoantibody values. The serum autoantibody values in each subject were quantified using automated ELISA. Descriptive statistics including, distributions, quantiles, and moments were calculated by zygosity for continuous antibody values, subject ages, gender, race and smoking status. Categorical antibody levels were used to determine twin pair concordance rates. Continuous and rank ordered autoantibody values were used to determine the presence and portion of a genetic component. To evaluate how strongly the antibody values in each twin group resembled each other, the intraclass correlation was calculated for each antibody by zygosity. The genetic variances, environmental variances, and heritability were estimated using path models with maximum likelihood estimation techniques. The phenotypic variance was modeled as a linear function of underlying additive genetic (A), dominant genetic (D), common environmental (C), and random environmental (E) effects. RESULTS: Several antibodies demonstrated a genetic component in our study population. Anti-cardiolipin had a genetic component with an estimated 69% heritability. Anti-dsDNA yielded a genetic component with a heritability estimate of 55-62%. Anti-Jo-1 presented a genetic component with the heritability estimate to be 41-51%. Anti-SCL-70 demonstrated a genetic component with a heritability estimate of 42-59%. Anti-PL had a genetic component with a heritability estimate of 52-54%. Several antibodies did not have a measurable genetic component. These included anti-Sm, anti-Ro(SSA), anti-La(SSB), anti-sn/RNP, anti-Tg, and anti-TPO. Some possibilities for the lack of a measureable genetic component may be due to the limited number of discordant twin pairs and/or the small number of subjects with higher levels of antibodies. CONCLUSION: The results of this study suggest several clinically relevant markers of auto-immunity may be partially genetically determined. These include: anti-cardiolipin, anti-dsDNA, anti-Jo-1, anti-SCL-70, and anti-phospholid.
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Stoianovici, Charles. "Directing Mesenchymal Stem Cells for Periodontal Regeneration." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5335.
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Background: Directing autogenous Mesenchymal Stem Cell (MSC) to defect sites has a great promise in bone regeneration. We designed a MSC specific, bone affinity peptide (E7HA7) by conjugating E7 with a polyglutamate hydroxyapatite (HA) binding motif. We sought to characterize the in-vivo releasing pattern and bioactivity of E7HA7. Methods: HA discs were coated with fluorescent labeled peptides E7HA7, E7HA2 or E7 were subcutaneously implanted in Sprague Dawley rats. In an ectopic bone formation model was used to test the in-vivo bioactivity of E7HA7 conjugated to DBM. Results: E7HA7 showed slower peptide release from scaffolds in comparison to other groups, being statistically significant at week 2 compared to E7, and to E7HA2 at week 4 and 8. In ectopic model, the medians for new bone formation in each group were: iDBM=0.041mm3, iDBM-E7=0.071mm3, aDBM=0.138mm3, and aDBM-E7=0.192mm3. Conclusions: Conjugation of E7 to polyglutamate bone binding domain showed slow releasing kinetics and osteoinductive potential.
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Noorzai, Marina, and Sara Nyhlén. "Compliance to periodontal treatment - Is compliance of smokers better or worse than that of non- smokers in periodontal treatment? Which additional factors affect compliance?" Thesis, Malmö högskola, Odontologiska fakulteten (OD), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-19820.
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SAMMANFATTNINGBakgrundParodontit är en kronisk sjukdom som beror på en endogen infektion i munhålan. Sjukdomen drabbar 8-20% av den vuxna befolkningen globalt och påverkas av såväl genetiska, systemiska och lokala faktorer, som av livsstilsfaktorer. En av de största livsstilsfaktorerna vid parodontal sjukdom är rökning. Rökning är både en stor riskfaktor för utveckling av parodontal sjukdom och en prediktor för en negativ behandlingsutkomst. I tidigare studier har rökare uppvisat en sämre följsamhet till parodontal stödbehandling än icke-rökare.Syfte, material och metodMed hjälp av tobaksanamneser, insamlade på avdelningen för parodontologi på tandvårdshögskolan vid Malmö högskola, var målet att via det elektroniska journalsystemet T4 utvärdera patienternas följsamhet till behandling. Vidare ville vi tydliggöra eventuella skillnader mellan rökare och icke-rökare, mellan olika åldersgrupper och mellan patienter med olika svårighetsgrader av parodontal skada. Tobaksanamneser från 213 patienter, insamlade under år 2013, inkluderades i studien. Samtliga journaler granskades och data relevant för studien extraherades enligt en utformad mall.Resultat och slutsatsEn signifikant skillnad gällande antalet återbud till planerad behandling kan ses mellan grupperna, där de rökande patienter har flest återbud. Antalet återbud påverkas också av bostadsort och parodontal diagnos. Även ålder och operatör kan påverka risken för återbud. Ytterligare skillnader mellan grupperna ses i relation till sysselsättning, där antalet sjukskrivna och arbetslösa patienter är överrepresenterade bland rökarna. Vidare studier bör utformas som prospektiva studier där patienter följs och behandlas enligt en kalibrerad mall. För att få mer pålitliga resultat behöver fler och bättre kontrollerade studier utföras i ämnet.ABSTRACTIntroductionPeriodontal disease is a chronic disease that depends on an endogenous infection in the oral cavity. The disease affects 8-20% of the adult population worldwide and is influenced by both genetic, systemic, local and lifestyle factors. One of the major lifestyle factors in periodontal disease is smoking. Smoking is both a major risk factor for development of periodontal disease and a predictor of adverse treatment outcome. In previous studies, smokers showed a lower adherence to periodontal support therapy.Study design, methods and materialUsing tobacco anamnesis, collected in the Department of Periodontology at the School of Dentistry at Malmö University, the purpose was to to evaluate patient compliance to treatment taking into account various variables. Tobacco anamnesis from 213 subjects collected in 2013, were included in the study. All records were reviewed and data relevant to the study extracted according to a designed template.Results and conclusionSmokers, and non-smokers were compared and significant differences between the groups regarding number of cancellations of planned treatment could be seen. Smokers tended to have more cancellations. The number of cancellations were affected by place of residence and periodontal diagnosis. Also age and therapist could affect the risk. Differences between the groups was seen in relation to employment, where unemployed patients, as well as patients in early retirement/long term sickness were overrepresented among smokers. To get more reliable results more and better -controlled studies are needed.
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Reddy, Bindu. "Interleukin-6 Levels in Generalized and Localized Aggressive Periodontitis Patients." VCU Scholars Compass, 2004. http://scholarscompass.vcu.edu/etd/1284.
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AbstractINTERLEUKIN-6 LEVELS IN GENERALIZED AND LOCALIZED AGGRESSIVE PERIODONTITIS PATIENTSBy Bindu Reddy, D.D.S.A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at the Virginia Commonwealth UniversityVirginia Commonwealth University, 2004Major Director: Joseph V. Califano, D.D.S., Ph.D.Associate Professor, Department of Periodontics Periodontitis is an inflammatory disease involving the supporting structures of the dentition. Many studies have shown that there is a relationship between periodontal disease, the presence of pro-inflammatory cytokines, and systemic disease such as cardiovascular disease and diabetes mellitus. The purpose of this study was to measure serum Interleukin-6 levels in generalized and localized aggressive periodontitis and non-periodontitis patients and look for relationships with measures of disease severity. We also examined variables known to have a relationship with IL-6. A total of 172 subjects, comprising three periodontal subgroups, non-periodontitis (NP=61), generalized aggressive periodontitis (GAP=77), and localized aggressive periodontitis (LAP= 34), had serum samples evaluated for IL-6 levels using a highly sensitive ELISA test. The IL-6 levels were compared with clinical and demographic data including age, race, gender, number of teeth, probing depth, attachment loss, bleeding index, plaque index, gingival index, cotinine levels, smoking status, and CRP levels. Using multiple regression analysis, smoking status (p=0.0015) was the only variable found to have a significant relationship with IL-6 levels for all three groups.
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Nascimento, David Furtado do. "Ortodontia osteogénica auxiliada pela periodontologia (PAOO) : interações atuais entre a ortodontia e periodontologia." Master's thesis, 2018. http://hdl.handle.net/10400.26/25547.
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Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas MonizO objetivo desta monografia assenta numa recolha geral de informação, em forma de revisão narrativa e bibliográfica, sobre o tema Ortodontia Osteogénica Auxiliada pela Periodontologia (PAOO) – Interações atuais entre a Ortodontia e Periodontologia. A Ortodontia Osteogénica Auxiliada pela Periodontologia (PAOO) é um procedimento clínico que combina corticotomia alveolar seletiva, enxertos ósseos particulados e aplicação de forças ortodônticas, podendo ser realizado em consultório. As limitações biológicas mantiveram-se as mesmas nos últimos séculos, as tecnológicas não. Esta técnica permitiu alargar o espetro do tratamento ortodôntico, permitindo a planificação e realização de tratamentos que previamente simplesmente não eram possíveis de executar, num espaço de tempo mais reducido. Uma abordagem multidisciplinar, com conhecimento dos desenvolvimentos mais recentes nos campos de Ortodontia e Periodontologia, juntamente com uma relação profissional próxima entre os clínicos de ambas as áreas, levam a uma otimização na qualidade e na gestão funcional e estética de qualquer procedimento. O potencial deste tratamento ainda necessita de ser melhor delineado e definido por ensaios clínicos bem planeados. No entanto, sabemos que a Ortodontia combinada com a corticotomias seletivas e enxertos ósseos tem produzido resultados francamente positivos e inovadores.
The objective of this monograph is based on a general collection of information, in the form of a narrative and bibliographical review, on the theme Periodontally Accelerated Osteogenic Orthodontics (PAOO) - Current Interactions between Orthodontics and Periodontology. Periodontally Accelerated Osteogenic Orthodontics (PAOO) is a clinical procedure that combines selective alveolar corticotomy, particulate bone grafts and orthodontic forces, and can be performed in the office. Biological limitations have remained the same in recent centuries, technological ones have not. This technique allowed to extend the spectrum of the orthodontic treatment, allowing the planning and realization of treatments that previously were simply not possible to execute, in a reduced time frame. A multidisciplinary approach, with knowledge of the latest developments in the fields of Orthodontics and Periodontology, together with a close professional relationship between clinicians in both areas, lead to an optimization in the quality and functional and aesthetic management of any procedure. The potential of this treatment still needs to be better delineated and defined by well-planned clinical trials. However, we know that Orthodontics combined with selective corticotomies and bone grafting has produced frankly positive and innovative results.
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Melero, Blanca Monje. "Periodontologia e ortodontia: tratamento interdisciplinar." Master's thesis, 2018. http://hdl.handle.net/10400.26/25158.
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Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas MonizAtualmente, cada vez há mais pessoas que se preocupam com a sua estética, sendo que muitas vezes escolhem para a sua correção a terapêutica ortodôntica. Uma grande percentagem da população adulta apresenta algum tipo de alteração ao nível do periodonto, como gengivite ou periodontite. O resultado mais grave da doença periodontal pode ser a perda de peças dentárias, mas pode encontrar-se de forma mais frequente outras alterações funcionais e estéticas, como por exemplo falta de gengiva queratinizada, recessão gengival, inserção inadequada do freio e aumento do volume gengival. Para este tipo de tratamentos é muito importante fazer uma análise ao nível do periodonto, uma vez que é uma estrutura dinâmica composta por tecidos que envolvem e suportam o dente, tendo sempre em consideração que os pacientes com doença periodontal são considerados pacientes de risco para a terapia ortodôntica. Dentro das deformidades que atingem o periodonto, é fundamental a sua identificação e o médico dentista tem que ter a capacidade de saber quando intervir, se antes, durante ou após o tratamento ortodôntico. É essencial fazer um estudo de cada defeito periodontal e um tratamento adequado destes, uma vez que a saúde periodontal é um fator determinante e necessário para o sucesso do tratamento ortodôntico. A evidência científica mostra que um tratamento ortodôntico adequado, que respeite uma correta higiene oral e que não apresente qualquer sinal de inflamação é um tratamento sem risco para o periodonto. O objetivo deste trabalho de monografia é a identificação das alterações do periodonto que podem condicionar o tratamento ortodôntico e que podem afetar ao sucesso do tratamento como um todo. Para isto é fundamental o clínico saber como e quando atuar em cada um dos casos, de forma que a abordagem multidisciplinar funcione da melhor forma levando a um resultado final ideal.
A large percentage of the adult population has some type of alteration at the level of the periodontium, such as gingivitis or periodontitis. The most serious result of the periodontal disease may be loss of teeth, although other functional and aesthetic alterations can be found more frequently, such as lack of keratinized gingiva, gingival recession, inadequate insertion of the frenum and gingival volume increase. Currently, the number of adult people who are concerned about their oral aesthetics has increased and they often choose orthodontic therapeutics in order to correct it. For this type of treatment it is very important to carry out an exhaustive analysis at the level of the periodontium, since this is a dynamic structure composed of tissues that wrap and support the tooth, always bearing in mind that patients with periodontal disease are considered risk patients for orthodontic therapy. Within the deformities that reach the periodontium, its identification is essential and the dentist must have the ability to know when to act, before, during or after the orthodontic treatment. Making a study and an appropriate treatment of each periodontal defect is basic, considering that periodontal health is a decisive and necessary factor for the success of orthodontic treatment. Scientific evidence shows that a suitable orthodontic treatment, which respects correct oral hygiene and does not present any sign of inflammation is a risk-free treatment for the periodontium. The aim of this study is the identification of alterations of the periodontium and to determine the success of the treatment as a whole. To achieve this goal it is essential that the clinician knows how and when to act in such a way that the multidisciplinary approach works the best way leading to an ideal final result.
Un gran porcentaje de la población adulta presenta algún tipo de alteración al nivel del periodonto, como gingivitis o periodontitis. El resultado más grave de la enfermedad periodontal puede ser la pérdida de piezas dentales, pero se pueden encontrar de forma más frecuente otras alteraciones funcionales y estéticas, como por ejemplo la falta de encía queratinizada, recesión gingival, inserción inadecuada del freno y aumento del volumen gingival. Actualmente, hay cada vez más personas adultas que se preocupan por su estética y a menudo eligen para la corrección de ésta la terapéutica ortodóntica. Para este tipo de tratamientos es muy importante hacer un exhaustivo análisis al nivel del periodonto, ya que éste es una estructura dinámica compuesta por tejidos que envuelven y soportan el diente, teniendo siempre en cuenta que los pacientes con enfermedad periodontal son considerados pacientes de riesgo para la terapia ortodóntica. Dentro de las deformidades que alcanzan el periodonto, es fundamental su identificación y el médico dentista tiene que tener la capacidad de saber cuándo actuar, si antes, durante o después del tratamiento ortodóntico. Es esencial hacer un estudio de cada defecto periodontal y un tratamiento adecuado de éstos, ya que la salud periodontal es un factor determinante y necesario para el éxito del tratamiento ortodóntico. La evidencia científica muestra que un tratamiento ortodóntico adecuado, que respeta una correcta higiene oral y que no presente ningún signo de inflamación es un tratamiento sin riesgo para el periodonto. El objetivo de este trabajo de monografia es la identificación de las alteraciones del periodonto y condicionar el éxito del tratamiento como un todo. Para ello es fundamental que el clínico sepa cómo y cuándo actuar de forma que el abordaje multidisciplinario funcione de la mejor manera llevando a un resultado final ideal.
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Lopes, Carolina Branca. "Aplicação de concentrados plaquetários em periodontologia." Master's thesis, 2020. http://hdl.handle.net/10400.26/35407.
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Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas MonizA crescente necessidade de encontrar produtos que melhorem a cicatrização, os resultados clínicos e o pós-operatório após procedimentos cirúrgicos levou ao desenvolvimento dos concentrados plaquetários (CPs), que podemos genericamente diferenciar em plasma rico em plaquetas (PRP) e fibrina rica em plaquetas (PRF). Os CPs aceleram os processos fisiológicos induzidos pela trombina, e conduzem à formação de fibrina e à ativação plaquetária. A presente revisão bibliográfica tem o objetivo de analisar a evidência científica mais recente referente à aplicação de concentrados plaquetários em periodontologia, bem como aferir os vários tipos, composições, protocolos, indicações e fatores que comprometem o sucesso clínico dos CPs. Foi realizada uma pesquisa bibliográfica utilizando os termos “platelet-rich plasma AND periodontal regeneration” ou “platelet-rich fibrin AND periodontal regeneration” ou “platelet-rich fibrin AND periodontal plastic surgery” ou “platelet-rich fibrin AND infra-bony defects” ou “platelet-rich fibrin AND furcation defects” ou “platelet-rich fibrin AND root coverage” nas bases de dados Pub-Med/Medline, Cochrane, Scielo e ScienceDirect. Em primeira instância foi dada preferência a meta-análises, revisões sistemáticas e a estudos randomizados controlados recentes, sendo que apenas foram selecionados artigos posteriores a 1996. Todos os CPs têm apresentado resultados promissores no controlo da hemorragia, redução do tempo de cicatrização e estimulação da regeneração tecidular. Contudo, os L-PRFs por terem protocolos mais simples, práticos e económicos são os mais utilizados em cirurgia periodontal. Apesar de existirem resultados heterogéneos entre vários estudos semelhantes, concluiu-se que os PRFs apresentam efeitos favoráveis no tratamento de defeitos infra-ósseos, de furca, e na cicatrização de tecidos moles. O sucesso do tratamento depende do rigor da preparação, padronização do protocolo e armazenamento dos CPs. De forma a melhorar a confiabilidade e previsibilidade clínicas destes biomateriais é necessário efectuar melhorias na padronização e formulação dos mesmos.
The growing need to find products that improve healing and clinical and postoperative results after surgical procedures has led to the development of platelet concentrates (CPs), which we can generically divide into platelet-rich plasma (PRP) and platelet-rich fibrin (PRF). CPs accelerate the physiological processes induced by thrombin and lead to the formation of fibrin and platelet activation. This literature review aims to analyze the most recent scientific evidence of the CPs in periodontology, as well as to assess the various types, compositions, protocols, indications and factors that compromise the clinical success of CPs. A bibliographic search was performed using the terms "platelet-rich plasma AND periodontal regeneration" or "platelet-rich fibrin AND periodontal regeneration", "platelet-rich fibrin AND periodontal plastic surgery"or "platelet-rich fibrin AND infra-bony defects" or “Platelet-rich fibrin AND furcation defects” and “platelet-rich fibrin AND root coverage” in the Pub-Med/Medline, Cochrane, Scielo and ScienceDirect databases. Preference was given to meta-analyzes, systematic reviews and recent randomized controlled studies and only articles after 1996 were selected. PCs have shown promising results in controlling bleeding, reducing healing time and stimulating tissue regeneration. However, because L-PRFs have simpler, practical and economical protocols, they are the most used in periodontal surgery. Although there are heterogeneous results among several similar studies, it was concluded that PRFs have favorable effects in the treatment of infra-bone defects, furcation, and in the healing of soft tissues. The success of treatment with PCs depends on the rigor of the preparation, standardization of the protocol and their storage. In order to improve the clinical reliability and predictability of these biomaterials, it is necessary to make improvements in their standardization and formulation.
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Camacho, Jorge Manuel Sousa. "Qualidade dos Registos Clínicos em Periodontologia." Dissertação, 2016. https://repositorio-aberto.up.pt/handle/10216/84588.
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Camacho, Jorge Manuel Sousa. "Qualidade dos Registos Clínicos em Periodontologia." Master's thesis, 2016. https://repositorio-aberto.up.pt/handle/10216/84588.
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Castro, Diogo Teixeira de. "A relação interdisciplinar entre ortodontia e periodontologia." Master's thesis, 2017. http://hdl.handle.net/10400.26/19835.
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Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas MonizA presente revisão bibliográfica aborda conceitos e princípios relativos à doença periodontal e ao tratamento ortodôntico. Ao longo dos anos, o número de doentes periodontais que necessitam de tratamento ortodôntico tem vindo a aumentar. Tendo em conta que este tipo de doentes apresentam um suporte periodontal reduzido, pela presença da doença periodontal, o tratamento ortodôntico tem de ser adaptado e planeado para estas condições. Nestes doentes a força ortodôntica deverá ser contínua e leve, assim como deve ser utilizado de preferência ligaduras metálicas, pois estas acumulam menos placa bacteriana. Para que se alcance o sucesso terapêutico é necessário que se consiga não só diagnosticar a presença da doença periodontal, assim como, realizar o plano de tratamento assertivo e adequado para estas situações. Deste modo, foi realizada uma pesquisa bibliográfica, utilizando como motor de busca Medline/Pubmed/Sciencemed/B-on, inserindo as seguintes palavras chaves: “Periodontal Disease”, “Periodontal Ligament”, “Periodontal Treatment”, “Orthodontic tooth movement”, “Interdisciplinary Treatment”, “Orthodontic Treatment”, “Orthodontics”, “Periodontics”, “Relapse”, “Aesthetics”, “Function”. Este trabalho teve como objetivo perceber quais são as principais considerações a ter em conta antes, durante e após o tratamento ortodôntico quando estamos perante doentes periodontalmente comprometidos, assim como, compreender a simbiose que existe entre a Periodontologia e a Ortodontia.
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Codeço, Andreia Filipa Carvalho Rodrigues. "Simulação em Periodontologia - do cenário à consulta." Dissertação, 2019. https://hdl.handle.net/10216/121732.
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Gonçalves, Ana Catarina Martins. "O papel do ácido hialurónico em periodontologia." Master's thesis, 2011. http://hdl.handle.net/10451/27217.
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Tese de mestrado, Medicina Dentária, Universidade de Lisboa, Faculdade de Medicina Dentária, 2011O ácido hialurónico é um glicosaminoglicano de alto peso molecular e um componente fundamental das matrizes extracelulares contribuindo significativamente para a hidrodinâmica dos tecidos, migração e proliferação celular. O uso do ácido hialurónico no tratamento de processos inflamatórios está estabelecido em várias áreas da medicina. No campo da Medicina Dentária, o ácido hialurónico mostrou propriedades anti-inflamatórias, anti-edematogénicas e anti-bacterianas para o tratamento de Gengivite e Periodontite. A sua administração em bolsas periodontais pode alcançar efeitos benéficos na regeneração de tecidos e tratamento da doença periodontal. Esta monografia constitui uma revisão bibliográfica sobre o uso do ácido hialurónico em Periodontologia na qual se pretende descrever as suas propriedades e funções e definir não só, as suas várias aplicações clínicas nesta área como também, a segurança, efeitos adversos bem como os principais produtos que existem disponíveis no mercado.
Hyaluronic acid is a high molecular weight glycosaminoglycan that forms a critical component of the extracellular matrix and contributes significantly to tissue hydrodynamics, cell migration and proliferation. The use of hyaluronic acid in the treatment of inflammatory process is established in many medical areas. In the field of dentistry, hyaluronate has shown anti-inflammatory, antiedematous and anti-bacterial effects for the treatment of gingivitis and periodontitis. Its administration to periodontal wound sites could achieve comparable beneficial effects in periodontal tissue regeneration and periodontal disease treatment. This paper provides a literature review on the use of hyaluronic acid in Periodontology in which to describe its properties and functions and define not only its various clinical applications in this area as well, safety, adverse effects and the main products available.
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Codeço, Andreia Filipa Carvalho Rodrigues. "Simulação em Periodontologia - do cenário à consulta." Master's thesis, 2019. https://hdl.handle.net/10216/121732.
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Lalmi, Myriam. "O tratamento mini invasivo em periodontologia em doente diabético." Master's thesis, 2017. http://hdl.handle.net/10400.26/19989.
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Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas MonizA evolução da medicina moderna e tecnologia, permitiu hoje a criação de terapêuticas menos invasiva em comparação com técnicas tradicionais, isso em função de resultados equivalentes ou melhores. Estas técnicas chamados minimamente invasivas tem como objetivo de ser o menos traumática possível, estes técnicas são numerosos eles estão desenvolvendo em conjunto com o conhecimento médico e avanços com a introdução de novas tecnologias e novos instrumentos como a microcirurgia ou laser. Especialmente, relativa ao campo da cirurgia periodontal com a cirurgia minimamente invasiva, que permite preservar, tanto quanto possível estrutura periodontal. Estes tratamentos minimamente invasivos são um benefício para os pacientes, especialmente aqueles que sofrem de doença sistémica crónica, especialmente nos concentramos sobre a doença que representam o mundo uma parte importante: o diabetes. Por isso tem sido mostrado que o diabete e doença periodontal tem uma relação de causa e efeito. O papel do médico-dentista no atendimento em estes doentes é de ter os conhecimentos sobre estes doenças e os impactos na cavidade oral e para a formação em técnicas dentária novas menor invasivas, Para que o médico dentista seja capaz de oferecer um serviço com qualidade.
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Araújo, Tiago Lisboa. "Abordagem de técnicas de cirurgia minimamente invasiva em Periodontologia." Master's thesis, 2018. http://hdl.handle.net/10400.26/25150.
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Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas MonizA Periodontologia é a área da medicina dentária que se dedica ao estudo, diagnóstico e tratamento das patologias que afetam os tecidos de suporte dos dentes, ou seja, osso de suporte e gengiva. Podemos afirmar que nos últimos anos a Periodontologia sofreu uma evolução sem precedentes, com a constante descoberta e evolução de conceitos da biologia básica, métodos de diagnóstico, novos instrumentos, biomateriais que auxiliam em processos de regeneração dos tecidos e o progresso tecnológico que nos permite, cada vez mais, ter equipamentos que nos auxiliam a ir além das capacidades físicas do nosso corpo. Com a introdução do microscópio cirúrgico, o endoscópio periodontal, o videoscópio, entre outros, o Médico Dentista dispõe atualmente de um arsenal que o proporciona, sem margem de dúvida, a execução de um tratamento periodontal com melhores taxas de sucesso e concretizadas em menor tempo, em virtude de melhor destreza técnica. A cirurgia minimamente invasiva aplicada ao tratamento periodontal foi uma das áreas que mais progrediu, não só devido à introdução de novos materiais e equipamentos, como também devidos aos diversos estudos e técnicas desenvolvidas na área. À medida que se descobrem os diversos benefícios que estas técnicas incorporam no tratamento da doença periodontal, também existe, concomitantemente, um crescente interesse em continuar a melhorar as diversas técnicas já aplicadas, aumentando a sua eficácia e taxas de sucesso de tratamento. O objetivo deste trabalho é rever a evolução da área da cirurgia minimamente invasiva no tratamento periodontal, as diversas técnicas utilizadas, os novos materiais e equipamentos que revolucionaram a área, assim como a sua eficácia e a sua evolução futura.
Periodontology is the field of dentistry that deals with the diagnostic and treatment of pathologies that affect the teethes supporting tissue, in other words, the supporting bone and gingiva. We can say that in the last few years the field of periodontology has undergone an unprecedented evolution, with the constant discovery and evolution of basic biological concepts, methods of diagnostic, new instruments, biomaterials that help in the tissues regenerative process and the technological progress that allows us to develop equipment that permits us to go beyond the physical capacities of our bodies. With the introduction of the surgical microscope, dental endoscope, videoscope, among others, the Dentist, now possesses a vast arsenal of equipment that, without a doubt, grants the periodontal treatment better success rates with less time consumption in virtue of better technical dexterity. Minimally invasive surgery applied to periodontal treatment was one of the fields that achieved most progress, not only due to the introduction of new materials and equipment, but as well as the development of new studies and techniques. As the new benefits that these new techniques bring to the periodontal treatment are discovered, at the same time there is a crescent interest in continuing to improve on the already known techniques, augmenting their efficiency and treatment success rates. The main objective of this work is to review the evolution of the minimally invasive surgery field in periodontal treatment, the diverse surgical techniques, new materials and equipment that revolutionized the field as well as to review their efficiency and future evolution.
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Valente, Vanessa Almeida. "Avaliação clínica dos enxertos gengivais realizados na consulta de periodontologia." Master's thesis, 2010. http://hdl.handle.net/10316/35225.
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Trabalho final do 5º ano com vista à atribuição do grau de mestre no âmbito do ciclo de estudos de Mestrado Integrado em Medicina Dentária apresentado à Faculdade de Medicina da Universidade de Coimbra.terapia peridontal ultrapassou o objectivo da eliminação e controlo da doença periodontal, para abarcar, na actualidade, uma crescente vertente estética. Surgiu assim a cirurgia plástica/estética periodontal que corrige ou elimina defeitos gengivais ou da mucosa alveolar provocados pelo desenvolvimento, traumáticos, induzidos por placa bacteriana ou derivados de anomalias anatómicas. Sendo as recessões gengivais uma patologia periodontal frequente com significativo comprometimento estético desenvolveram-se diversas técnicas cirúrgicas de enxerto gengival, conducentes ao recobrimento radicular e/ou aumento da gengiva aderente. Este trabalho propõe-se a efectuar a avaliação retrospectiva das cirurgias de enxerto gengival, realizadas no âmbito da disciplina de Periodontologia. Após recolha de todos os casos de recessão gengival sujeitos a cirurgia de enxerto gengival, registados desde 2000, procedeu-se ao seu controlo clínico. Obteve-se valores de recessão gengival médios de 4,7mm para pré-operatório e 3,47mm para o controlo de 4 aos pós cirurgia, o recobrimento radicular médio foi 34,33% e não se obteve nenhum recobrimento radicular total. Periodontal therapy exceeded the target of the elimination and control of periodontal disease, to encompass, at present, a growing part aesthetics. Thus emerged the plastic surgery/cosmetic periodontal that corrects or eliminates gingival or alveolar mucosa defects caused by development, trauma, induced by dental plaque or derivatives of anatomical abnormalities. Since the gingival recession is a frequent periodontal disease with a significant esthetic, several gingival graft techniques were developed, leading to root coverage and/or increase the gum adhesive. This paper proposes to carry out retrospective evaluation of gingival graft surgery, performed under the discipline of Periodontology. After collecting all the cases undergoing surgery gingival recession gingival graft, registered since 2000, was done a query control, resulting in percentages of 34,33% for mean root coverage, with no complete root coverage in any patient. The baseline recession depth was 4,7 and the follow-up recession depth was 3,47.
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Valente, Pedro Manuel Oliveira. "Inter-relação da periodontologia e ortodontia em pacientes adultos: revisão bibliográfica." Master's thesis, 2015. http://hdl.handle.net/10400.26/11728.
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Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas MonizO número de pacientes periodontais que procuram o tratamento ortodôntico tem vindo a aumentar, sendo um dos seus principais objetivos corrigir a migração dentária patológica que lhes é característica. Este tipo de pacientes é considerado um grupo de risco, visto terem um reduzido nível ósseo para suportar as forças ortodônticas, as quais, quando aplicadas em presença de inflamação gengival, potenciam a perda de tecido de inserção. Nestes pacientes é aconselhado o uso de ligaduras metálicas, uma vez que, segundo a literatura, apresentam menor acumulação de placa bacteriana, quando comparado com as ligaduras elásticas. O uso de bandas ortodônticas também potencia a acumulação da placa bacteriana, aumentando, dessa forma, o risco de inflamação gengival. Deste modo, é de evitar, sempre que possível, a sua utilização. São recomendadas a aplicação de forças ligeiras, momentos de ativação do aparelho mais longos e aplicação de forças o mais próximo possível do centro de resistência visto que permite diminuir a magnitude do momento da força e assim a probabilidade de ocorrência de movimentos de inclinação é menor. O tratamento ortodôntico num paciente periodontal é dividido em três fases, a fase préortodôntica, a fase ortodôntica e a fase pós-ortodôntica. Independentemente da fase em que o tratamento se encontra, é necessário a manutenção do estado de saúde periodontal. Considerações estéticas, tal como recessão gengival, assimetria da margem gengival, ausência de papila interdentária e sorriso gengival, devem ser tidas em consideração aquando do plano de tratamento. A movimentação ortodôntica dentária é difícil de se manter, sem recidiva, uma vez que após o movimento ortodôntico, ocorre uma reorganização das fibras de colagénio, fibras elásticas e fibras do ligamento periodontal. Assim, a utilização de uma contenção fixa ou removível é importante para assegurar a estabilidade da nova posição dentária e suportar os dentes com perda óssea severa.
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Carvalho, Diogo Filipe Costa. "PREVALÊNCIA DO MAU HÁLITO NA CONSULTA DE PERIODONTOLOGIA NA CLÍNICA DA FMDUP." Dissertação, 2016. https://repositorio-aberto.up.pt/handle/10216/84488.
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Carvalho, Diogo Filipe Costa. "PREVALÊNCIA DO MAU HÁLITO NA CONSULTA DE PERIODONTOLOGIA NA CLÍNICA DA FMDUP." Master's thesis, 2016. https://repositorio-aberto.up.pt/handle/10216/84488.
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Afonso, André Filipe Rodrigues. "Caraterização dos utentes das consultas de periodontologia na Clínica Dentária Universitária Egas Moniz." Master's thesis, 2016. http://hdl.handle.net/10400.26/15347.
Full textAbstract:
Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas MonizObjetivo: caraterizar os utentes das consultas de periodontologia da clínica dentária universitária Egas Moniz, procurando identificar os fatores de risco mais associados à doença periodontal (DP) desta população. Material e método: estudo observacional, analítico e transversal, efetuado numa amostra de conveniência de 150 utentes das consultas de periodontologia, aos quais se aplicou previamente um consentimento informado, um questionário e recolheu-se adicionalmente alguns dados dos processos clínicos. Os dados clínicos e laboratoriais recolhidos foram introduzidos no Programa Microsoft Excel, para ser realizada, à posteriori, uma integração com a base de dados criada com recurso ao software SPSS® (Statistical Package for the Social Sciences), programa através do qual se realizou a análise estatística. Resultados: a amostra na sua maioria é igualmente distribuída entre géneros, predominantemente caucasiana (95%), adultos com idades entre os 50 e 69 anos (58%), com médios e baixos níveis de escolaridade, baixo nível socioeconómico, com PC severa generalizada, com alisamentos radiculares já realizados (77%), bons hábitos de higiene oral, consumidores de álcool, fumadores, com elevados níveis de índice de massa corporal (IMC) e sem toma dos fármacos ou doenças sistémicas em questão. Conclusões: fatores de risco como a idade, o nível socioeconómico, as habilitações literárias, os tratamentos periodontais realizados, os métodos de higiene oral, o consumo de álcool, os hábitos tabágicos e o IMC, relacionam-se com a DP.
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Clemente, Luís Guilherme Carvalho. "Otimização do registo clínico electrónico em periodontologia : casuística das patologias periodontais de uma clínica universitária." Master's thesis, 2017. http://hdl.handle.net/10400.14/23884.
Full textAbstract:
Introdução: os registos clínicos são parte integrante do exercício da arte Médica
merecendo especial atenção na forma como são efetuados. Atualmente, na
Medicina Dentária, estes são cada vez mais realizados em suporte eletrónico e,
portanto, torna-se importante a otimização dos mesmos no sentido de recolher
informação clínica o mais completa possível, de uma forma simples e eficaz.
Objetivos: otimização de um RCE com inclusão de um módulo de classificação
de diagnóstico periodontal; realização de uma casuística de patologias
periodontais através de um RCE.
Materiais e Métodos: numa primeira fase, formulou-se um modelo conceptual
para registo de patologias periodontais, com vista ao desenvolvimento de um
módulo de RCE, a integrar no programa Newsoft®, utilizado na Clínica Dentária
Universitária da Universidade Católica Portuguesa, em Viseu. Após
implementação dessa ferramenta informática, desenvolveu-se um estudo
prospetivo, com uma recolha de dados clínicos periodontais realizada entre o
período de 22 de fevereiro e 10 de maio de 2017, que incluiu todos os doentes
residentes no distrito de Viseu que recorreram à clinica para tratamentos
periodontais. Foram analisadas as variáveis: código postal, idade, género,
hábitos tabágicos, patologia cardiovascular, HTA, diabetes e sua tipologia e o
diagnóstico periodontal.
Resultados: o módulo de registo das patologias periodontais foi introduzido no
sistema de RCE da clínica universitária, para a atribuição de um diagnóstico
periodontal a cada um dos pacientes e. De 158 pacientes registados, apenas
134 apresentaram todas as variáveis introduzidas. Os diagnósticos mais
frequentes foram as periodontites seguidas das doenças gengivais. Nas
periodontites, a crónica foi sem dúvida a mais frequente, enquanto nas gengivais
foi a induzida por placa. As periodontites surgiram em idades mais avançadas
que as doenças gengivais (p<0,01). A presença de patologia cardiovascular
(p=0,04) assim como a HTA (p=0,03) mostrou uma relação com a periodontite
em comparação com as doenças gengivais. Não se encontrou diferença
significativa quanto aos hábitos tabágicos e à presença ou tipo de diabetes. Quanto à gravidade da periodontite crónica apenas o aumento da idade parece
ter relação (p<0,01).
Conclusão: o RCE é uma ferramenta essencial a aplicar por todos os clínicos,
tornando-se fundamental a sua uniformização, facilitando a realização de
estudos casuísticos/ epidemiológicos na área da Periodontologia.