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1

Milicevic, Radovan, Gavrilo Brajovic, Natasa Nikolic-Jakoba, et al. "Identification of periodontopathogen microorganisms by PCR technique." Srpski arhiv za celokupno lekarstvo 136, no. 9-10 (2008): 476–80. http://dx.doi.org/10.2298/sarh0810476m.

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INTRODUCTION Periodontitis is an inflammatory disease of the supporting tissues of teeth and is a major cause of tooth loss in adults. The onset and progression of periodontal disease is attributed to the presence of elevated levels of a consortium of pathogenic bacteria. Gram negative bacteria, mainly strict anaerobes, play the major role. OBJECTIVE The present study aimed to assess the presence of the main types of microorganisms involved in the aetiopathogenesis of periodontal disease: Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Eikenella corrodens, Treponema denticola,
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B, Ashwath, Adline Vadhana D, Anitha V, and Shanmugam M. "Aggregatibacter actinomycetemcomitans- A periodontopathogen." IP International Journal of Periodontology and Implantology 6, no. 2 (2021): 61–67. http://dx.doi.org/10.18231/j.ijpi.2021.011.

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is a gram-negative oral pathobiont that is associated with severe form of periodontitis. This bacterium has various virulence factors which enables the bacterium to colonize the oral cavity, invade and evade the host defences. Leukotoxin and cytolethal distending toxin are the important virulence factors that causes periodontal destruction. Periodontal infections with seems to be refractory to conventional therapy and systemic antibiotics. Hence, leukotoxin represents an ideal anti-virulence target and inhibition of its immunosuppressive activity would eliminate the colonization advantage prov
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Teughels, W., M. G. Newman, W. Coucke, et al. "Guiding Periodontal Pocket Recolonization: a Proof of Concept." Journal of Dental Research 86, no. 11 (2007): 1078–82. http://dx.doi.org/10.1177/154405910708601111.

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The complexity of the periodontal microbiota resembles that of the gastro-intestinal tract, where infectious diseases are treatable via probiotics. In the oropharyngeal region, probiotic or replacement therapies have shown some benefit in the prevention of dental caries, otitis media, and pharyngitis, but their effectiveness in the treatment of periodontitis is unknown. Therefore, this study addressed the hypothesis that the application of selected beneficial bacteria, as an adjunct to scaling and root planing, would inhibit the periodontopathogen recolonization of periodontal pockets. Analysi
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Ha, Jae Yeong, Jiwon Seok, Suk-Jeong Kim, et al. "Periodontitis promotes bacterial extracellular vesicle-induced neuroinflammation in the brain and trigeminal ganglion." PLOS Pathogens 19, no. 10 (2023): e1011743. http://dx.doi.org/10.1371/journal.ppat.1011743.

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Gram-negative bacteria derived extracellular vesicles (EVs), also known as outer membrane vesicles, have attracted significant attention due to their pathogenic roles in various inflammatory diseases. We recently demonstrated that EVs secreted by the periodontopathogen Aggregatibacter actinomycetemcomitans (Aa) can cross the blood–brain barrier (BBB) and that their extracellular RNA cargo can promote the secretion of proinflammatory cytokines, such as IL-6 and TNF-α, in the brain. To gain more insight into the relationship between periodontal disease (PD) and neuroinflammatory diseases, we inv
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Mintz, Keith P., and Paula M. Fives-Taylor. "impA, a Gene Coding for an Inner Membrane Protein, Influences Colonial Morphology of Actinobacillus actinomycetemcomitans." Infection and Immunity 68, no. 12 (2000): 6580–86. http://dx.doi.org/10.1128/iai.68.12.6580-6586.2000.

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ABSTRACT Directed mutagenesis of a gene coding for a membrane protein of the periodontopathogen Actinobacillus actinomycetemcomitans was achieved by conjugation. The gene was disrupted by insertion of an antibiotic cassette into a unique endonuclease restriction sequence engineered by inverse PCR. The disrupted gene was cloned into a conjugative plasmid and transferred from Escherichia colito A. actinomycetemcomitans. The allelic replacement mutation resulted in the loss of a 22-kDa inner membrane protein. The loss of this protein (ImpA) resulted in changes in the outer membrane protein compos
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de Andrade, Kívia Queiroz, Cássio Luiz Coutinho Almeida-da-Silva, and Robson Coutinho-Silva. "Immunological Pathways Triggered byPorphyromonas gingivalisandFusobacterium nucleatum: Therapeutic Possibilities?" Mediators of Inflammation 2019 (June 24, 2019): 1–20. http://dx.doi.org/10.1155/2019/7241312.

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Porphyromonas gingivalis(P. gingivalis) andFusobacterium nucleatum(F. nucleatum) are Gram-negative anaerobic bacteria possessing several virulence factors that make them potential pathogens associated with periodontal disease. Periodontal diseases are chronic inflammatory diseases of the oral cavity, including gingivitis and periodontitis. Periodontitis can lead to tooth loss and is considered one of the most prevalent diseases worldwide.P. gingivalisandF. nucleatumpossess virulence factors that allow them to survive in hostile environments by selectively modulating the host’s immune-inflammat
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Hanel, Alyssa N., Hannah M. Herzog, Michelle G. James, and Giancarlo A. Cuadra. "Effects of Oral Commensal Streptococci on Porphyromonas gingivalis Invasion into Oral Epithelial Cells." Dentistry Journal 8, no. 2 (2020): 39. http://dx.doi.org/10.3390/dj8020039.

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The objective of this study was to determine if the interaction between common oral commensal bacteria and oral epithelial cells would provide protective effects against the invasion of periodontopathogen Porphyromonas gingivalis. Oral epithelial OKF6/Tert cells were used in co-cultures with Streptococcus gordonii, Streptococcus oralis, Streptococcus mitis, and Streptococcus intermedius. The viability of OKF6/Tert cells following a bacterial challenge was evaluated by trypan blue exclusion. The adherence of commensal species was determined by CFU counts. P. gingivalis invasion in OKF6/Tert cel
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Amalia, Nadya Rafika, Theresia Indah Budhy, Rini Devijanti Ridwan, et al. "Propolis nanoemulsion extract from celebes stingless bee (Tetragonula biroi) phytochemistry and antibacterial analysis to periodontopathogen bacteria." Journal of Oral Biology and Craniofacial Research 15, no. 3 (2025): 576–84. https://doi.org/10.1016/j.jobcr.2025.03.013.

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9

Velusamy, S. K., R. Poojary, R. Ardeshna, Waad Alabdulmohsen, D. H. Fine, and K. Velliyagounder. "Protective Effects of Human Lactoferrin during Aggregatibacter actinomycetemcomitans-Induced Bacteremia in Lactoferrin-Deficient Mice." Antimicrobial Agents and Chemotherapy 58, no. 1 (2013): 397–404. http://dx.doi.org/10.1128/aac.00020-13.

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ABSTRACTAggregatibacter actinomycetemcomitans, a periodontopathogen, has been associated with several systemic diseases. Herein, we report the protective effect of human lactoferrin (hLF) duringA. actinomycetemcomitansbacteremia in lactoferrin knockout (LFKO−/−) mice. The prophylactic, concurrent, and therapeutic intravenous (i.v.) administrations of hLF significantly cleared the bacteria from blood and organs. Nevertheless, all modes of hLF administration significantly decreased the concentrations of serum proinflammatory cytokines, such as interferon gamma (IFN-γ), tumor necrosis factor alph
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10

Moon, Ji-Hoi, Jae-Hong Park, and Jin-Yong Lee. "Antibacterial Action of Polyphosphate onPorphyromonas gingivalis." Antimicrobial Agents and Chemotherapy 55, no. 2 (2010): 806–12. http://dx.doi.org/10.1128/aac.01014-10.

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ABSTRACTPolyphosphate [poly(P)] has antibacterial activity against various Gram-positive bacteria. In contrast, Gram-negative bacteria are generally resistant to poly(P). Here, we describe the antibacterial characterization of poly(P) against a Gram-negative periodontopathogen,Porphyromonas gingivalis. The MICs of pyrophosphate (Na4P2O7) and all poly(P) (Nan+ 2PnO3n+ 1;n= 3 to 75) tested for the bacterium by the agar dilution method were 0.24% and 0.06%, respectively. Orthophosphate (Na2HPO4) failed to inhibit bacterial growth. Poly-P75 was chosen for further study. In liquid medium, 0.03% pol
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Gatto, Claudia C., Daniel J. de Siqueira, Eduardo de A. Duarte, et al. "Exploring the Structural Design, Antibacterial Activity, and Molecular Docking of Newly Synthesized Zn(II) Complexes with NNO-Donor Carbazate Ligands." Molecules 30, no. 13 (2025): 2822. https://doi.org/10.3390/molecules30132822.

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The present work reports the synthesis and structural design of three novel Zn(II) complexes [Zn(L1)(CH3COO)(H2O)] (1), [Zn(L2)2] (2), and [Zn(L3)2] (3) with carbazate ligands, 2-acetylpyridine-methylcarbazate (HL1), 2-acetylpyridine-ethylcarbazate (HL2), and 2-acetylpyridine-benzylcarbazate (HL3). All compounds were characterized by spectroscopic methods, and the crystal structures of the complexes were elucidated by single-crystal X-ray. Based on the analysis, distorted square pyramid geometry is suggested for complex (1) and an octahedral geometry is suggested for complexes (2) and (3) with
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Nokhbehsaim, Marjan, Anna Damanaki, Andressa Vilas Boas Nogueira, et al. "Regulation of Ghrelin Receptor by Periodontal Bacteria In Vitro and In Vivo." Mediators of Inflammation 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/4916971.

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Ghrelin plays a major role in obesity-related diseases which have been shown to be associated with periodontitis. This study sought to analyze the expression of the functional receptor for ghrelin (GHS-R1a) in periodontal cells and tissues under microbial conditions in vitro and in vivo. The GHS-R1a expression in human periodontal cells challenged with the periodontopathogen Fusobacterium nucleatum, in gingival biopsies from periodontally healthy and diseased individuals, and from rats with and without ligature-induced periodontitis was analyzed by real-time PCR, immunocytochemistry, and immun
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Salma, Yasmin Hanifa, Chrysanti Murad, and Imam Megantara. "Oral Health Care and Aspiration Pneumonia." Odonto : Dental Journal 11, no. 2 (2024): 347. https://doi.org/10.30659/odj.11.2.347-358.

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Background: Oral health care is important to prevent aspiration pneumonia. Poor oral hygiene in elderly patients heightens the risk of aspiration pneumonia due to the growth of potential periodontopathogen bacteria. This literature review aims to describe the effect of oral health care on the incidence of pneumonia and/or the number of oral bacteria.Method: The literature search was conducted based on the PRISMA guideline with the PICO framework by utilizing electronic search engines in databases: PubMed, Cochrane's Library, and Google Scholar from March through May 2024. All articles to be re
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Vlasa, Alexandru, Carmen Biriș, Luminița Lazăr, et al. "Detection and Quantification of Periodontopathogenic Bacteria in Subgingival Plaque Samples on Patients Undergoing Orthodontic Treatment." Journal of Interdisciplinary Medicine 1, no. 2 (2016): 165–67. http://dx.doi.org/10.1515/jim-2016-0034.

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Abstract Introduction: According to last years' research, periodontopathogens may have a negative impact on treatment options in patients with periodontal lesions. However, not all infected sites suffer periodontal destructions, which can be explained on the assumption that only a limited number of pathogens present in a sufficient amount, are capable of affecting the periodontal tissue. Thermal cycling polymerase chain reaction (PCR) is a new technique used for the identification and quantification of periodontopathogenic bacteria. The aim of our study was to confirm the presence of periodont
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Sebe, Mayu, Satoka Senoura, Kiyoshi Miura, et al. "Antibacterial Activity of Banglene Extracted from Indonesian Ginger “Bangle” Against Porphyromonas gingivalis." International Journal of Molecular Sciences 26, no. 5 (2025): 1787. https://doi.org/10.3390/ijms26051787.

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Periodontitis is one of the most common diseases associated with the lifestyle habits of adults and is caused by the formation of biofilms, called dental plaques, in periodontal pockets by oral bacteria, such as Porphyromonas gingivalis. Bangle, Zingiber purpureum Rosc. (Indonesian ginger), a native Indonesian plant, has been traditionally consumed as food and medicine across Southeast Asia. The cis- and trans-banglenes, components of the rhizomes of Z. purpureum, have been reported to possess neurotrophic activity. Hexane extract of bangle exhibited antibacterial activity against P. gingivali
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Panas, Marta, Adriana Baryliyak, and Olena Korniychuk. "Application of low-level laser radiation with TiO2, Ag/TiO2 and S/TiO2 on Streptococcus salivarius isolated from the oral cavity." Current Issues in Pharmacy and Medical Sciences 27, no. 3 (2014): 148–50. http://dx.doi.org/10.1515/cipms-2015-0004.

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ABSTRACT In our research, we determine the effect of low-level laser irradiation with nanoparticles on Streptococcus salivarius. Photodynamic killing of periodontopathogenic bacteria may be an alternative to the systemic application of antibacterial drugs used in the treatment of periodontal diseases. The application of photosensitizing nanoparticles and their excitation by visible light of blue spectra enables effective killing of periodontopathogens. This data combined with the results demonstrates that TiO2, AgTiO2 and S/TiO2 can inhibit the proliferation of Streptococcus salivarius due to
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Buonavoglia, Alessio, Adriana Trotta, Michele Camero, Marco Cordisco, Michela Maria Dimuccio, and Marialaura Corrente. "Streptococcus mutans Associated with Endo-Periodontal Lesions in Intact Teeth." Applied Sciences 12, no. 22 (2022): 11837. http://dx.doi.org/10.3390/app122211837.

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A massive periodontal destruction can affect the root canal (RC) system and potentially expose the pulpo-dentinal complex to opportunistic bacteria. Streptococcus mutans is a major pathogen of human caries and periodontal diseases, and its virulence mostly resides in the ability to adhere to collagen and form biofilms, due to collagen-binding proteins (CBPs) Cnm and Cbm. Seventeen patients affected by severe endo-periodontal lesions without caries and/or exposure of pulpal tissue were subjected to tooth extraction and samples for microbiological investigation were collected from the root surfa
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Kataoka, Kosuke, Atsuo Amano, Shigetada Kawabata, Hideki Nagata, Shigeyuki Hamada, and Satoshi Shizukuishi. "Secretion of Functional Salivary Peptide by Streptococcus gordonii Which Inhibits Fimbria-Mediated Adhesion ofPorphyromonas gingivalis." Infection and Immunity 67, no. 8 (1999): 3780–85. http://dx.doi.org/10.1128/iai.67.8.3780-3785.1999.

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ABSTRACT Porphyromonas gingivalis, a putative periodontopathogen, can bind to human salivary components with its fimbriae. We have previously shown that fimbriae specifically bind to a peptide domain shared by a major salivary component, i.e., proline-rich (glyco)proteins (PRPs). The synthetic domain peptide PRP-C (pPRP-C) significantly inhibits the fimbrial binding to PRPs. In this study, a recombinant strain of Streptococcus gordonii secreting pPRP-C was generated as a model of a possible approach to prevent the oral colonization by the pathogen. A duplicate DNA fragment (prpC) encoding pPRP
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He, Jia, Hiroshi Miyazaki, Cecilia Anaya, Fan Yu, W. Andrew Yeudall, and Janina P. Lewis. "Role of Porphyromonas gingivalis FeoB2 in Metal Uptake and Oxidative Stress Protection." Infection and Immunity 74, no. 7 (2006): 4214–23. http://dx.doi.org/10.1128/iai.00014-06.

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ABSTRACT Porphyromonas gingivalis, a gram-negative anaerobic bacterium, is a recognized periodontopathogen. It exhibits a high degree of aerotolerance and is able to survive in host cells, indicating that efficient oxidative stress protection mechanisms must be present in this organism. Manganese homeostasis plays a major role in oxidative stress protection in a variety of organisms; however, the transport and role of this metal in P. gingivalis is not well understood. Analysis of the genome of P. gingivalis W83 revealed the presence of two genes encoding homologs of a ferrous iron transport p
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Grishaeva, Kseniya A., Andrey V. Sevbitov, Tat'yana V. Tsareva, Aleksandr V. Khodorov, Mariya D. Timoshina, and Mariya Y. Kuznetsova. "Changes in oral microbiota at different stages of active orthodontic treatment." I.P. Pavlov Russian Medical Biological Herald 32, no. 4 (2024): 529–38. https://doi.org/10.17816/pavlovj321672.

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INTRODUCTION: There are no sufficient numbers of studies in the modern literature devoted to investigation of the relationship between the use of fixed orthodontic appliances and changes in the qualitative and quantitative bacterial composition at certain periods of orthodontic treatment. AIM: To identify changes in the qualitative and quantitative composition of the microbiocenosis in the area of installed fixed appliances at different periods of orthodontic treatment. MATERIALS AND METHODS: The study included 40 participants aged 18–44 years. All patients had a history of occlusion pathologi
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Tankova, Hristina, and Nadezhda Mitova. "Subgingival Microbiome Profiles in Bulgarian Children Aged 10–14 with Gingival Inflammation and Healthy Periodontium: A Targeted PCR Study." Microorganisms 13, no. 7 (2025): 1656. https://doi.org/10.3390/microorganisms13071656.

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The subgingival microbiome is a critical component of the oral microbiota and plays a central role in pediatric periodontology. This study investigated differences in periodontopathogen profiles in children with gingival inflammation compared to healthy controls using real-time PCR, with a focus on the microbial complexes defined by Socransky. A total of 73 children (ages 10–14) underwent comprehensive periodontal assessment, including assessments of general health status, the O’Leary hygiene index (HI), gingival condition, and the papillary bleeding index (PBI). Subgingival plaque samples wer
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Davidovich, Nataliya Valerievna, A. S. Galieva, A. S. Opravin, et al. "Correlation of marker periodontopathogenic bacteria with the immune component sCD14 secretion level in inflammatory periodontal diseases." Russian Clinical Laboratory Diagnostics 67, no. 8 (2022): 471–75. http://dx.doi.org/10.51620/0869-2084-2022-67-8-471-475.

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Lipopolysaccharide of the cell wall of gram-negative bacteria is a highly active biological substance: its interaction with toll-like receptors-4 (TLR-4) of myeloid cells leads to the activation of a cascade of inflammatory reactions, which is accompanied by the release of the soluble CD14 receptor (sCD14), which can be considered not only as a marker of cell activation by endotoxin, but also as a marker of microbial translocation. The aim of the work was to assess the prognostic significance of the sCD14 level in the samples of the periodontal pocket in inflammatory periodontal diseases and t
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Yuan, Lihui, Jeffrey D. Hillman, and Ann Progulske-Fox. "Microarray Analysis of Quorum-Sensing-Regulated Genes in Porphyromonas gingivalis." Infection and Immunity 73, no. 7 (2005): 4146–54. http://dx.doi.org/10.1128/iai.73.7.4146-4154.2005.

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ABSTRACT Quorum sensing is a phenomenon defined as gene regulation in response to cell density that regulates various functions in bacteria. The periodontopathogen Porphyromonas gingivalis possesses a luxS gene homologue that may encode a quorum-sensing system. In order to identify genes of P. gingivalis that are regulated by luxS, gene expression analysis was done using microarrays and RNA samples from the W83 wild-type strain and an isogenic luxS mutant, LY2001. The results indicated that 17 open reading frames (ORFs) in LY2001 are upregulated and two are downregulated. Real-time PCR was don
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Cafiero, Concetta, Cristina Grippaudo, Marco Dell’Aquila, et al. "Association between Vitamin D Receptor Gene Polymorphisms and Periodontal Bacteria: A Clinical Pilot Study." Biomolecules 12, no. 6 (2022): 833. http://dx.doi.org/10.3390/biom12060833.

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Background: Periodontitis is an inflammatory disease caused by microorganisms involving the supporting tissues of the teeth. Gene variants may influence both the composition of the biofilm in the oral cavity and the host response. The objective of the study was to investigate the potential correlations between the disease susceptibility, the presence and the quantity of periodontopathogenic oral bacterial composition and the VDR gene polymorphisms. Methods: Fifty (50) unrelated periodontal patients and forty-one (41) healthy controls were selected for genomic DNA extraction. DNA concentration
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Martellacci, Leonardo, Gianluca Quaranta, Romeo Patini, Gaetano Isola, Patrizia Gallenzi, and Luca Masucci. "A Literature Review of Metagenomics and Culturomics of the Peri-implant Microbiome: Current Evidence and Future Perspectives." Materials 12, no. 18 (2019): 3010. http://dx.doi.org/10.3390/ma12183010.

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Background and objectives: In recent years, many different culture-independent molecular techniques have been developed with the aim of investigating the not yet cultivated part of the resident flora of the oral cavity and of analyzing the peri-implant and periodontal flora both in healthy and diseased sites. The most used technologies are Roche 454 pyrosequencing, Illumina HiSeq/MiSeq, ABI SOLiD and Ion Torrent. Due to these methods, two different approaches are available: Metagenomics and the 16S gene analysis. A complementary strategy was also recently developed: Culturomics. Culturomics co
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Sharma, Ashu, Hakimuddin T. Sojar, Ingrid Glurich, Kiyonobu Honma, Howard K. Kuramitsu, and Robert J. Genco. "Cloning, Expression, and Sequencing of a Cell Surface Antigen Containing a Leucine-Rich Repeat Motif from Bacteroides forsythus ATCC 43037." Infection and Immunity 66, no. 12 (1998): 5703–10. http://dx.doi.org/10.1128/iai.66.12.5703-5710.1998.

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ABSTRACT Bacteroides forsythus is a recently recognized human periodontopathogen associated with advanced, as well as recurrent, periodontitis. However, very little is known about the mechanism of pathogenesis of this organism. The present study was undertaken to identify the surface molecules of this bacterium that may play roles in its adherence to oral tissues or triggering of a host immune response(s). The gene (bspA) encoding a cell surface-associated protein of B. forsythus with an apparent molecular mass of 98 kDa was isolated by immunoscreening of a B. forsythus gene library constructe
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Rath-Deschner, Birgit, Svenja Memmert, Anna Damanaki, et al. "CXCL1, CCL2, and CCL5 modulation by microbial and biomechanical signals in periodontal cells and tissues—in vitro and in vivo studies." Clinical Oral Investigations 24, no. 10 (2020): 3661–70. http://dx.doi.org/10.1007/s00784-020-03244-1.

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Abstract Objectives This study was established to investigate whether the chemokines CXCL1, CCL2, and CCL5 are produced in periodontal cells and tissues and, if so, whether their levels are regulated by microbial and/or mechanical signals. Materials and methods The chemokine expression and protein levels in gingival biopsies from patients with and without periodontitis were analyzed by RT-PCR and immunohistochemistry. The chemokines were also analyzed in gingival biopsies from rats subjected to experimental periodontitis and/or orthodontic tooth movement. Additionally, chemokine levels were de
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Percival, Rimondia S., Philip D. Marsh, Deirdre A. Devine, et al. "Effect of Temperature on Growth, Hemagglutination, and Protease Activity of Porphyromonas gingivalis." Infection and Immunity 67, no. 4 (1999): 1917–21. http://dx.doi.org/10.1128/iai.67.4.1917-1921.1999.

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ABSTRACT Bacteria persisting in periodontal pockets are exposed to elevated temperatures during periods of inflammation. Temperature is an environmental factor that can modulate gene expression. Consequently, in the present study we examined the effect of temperature on the expression of virulence determinants by the periodontopathogen,Porphyromonas gingivalis. P. gingivalis W50 was grown in a complex medium under hemin excess at pH 7.0 and at a constant temperature of either 37, 39, or 41°C; cultures were monitored for protease and hemagglutinin activity. P. gingivalis grew well at all three
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van Essche, Mark, Gitte Loozen, Christof Godts, et al. "Bacterial Antagonism Against Periodontopathogens." Journal of Periodontology 84, no. 6 (2013): 801–11. http://dx.doi.org/10.1902/jop.2012.120261.

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Guevara, Tibisay, Arturo Rodriguez-Banqueri, Miroslaw Ksiazek, Jan Potempa, and F. Xavier Gomis-Rüth. "Structure-based mechanism of cysteine-switch latency and of catalysis by pappalysin-family metallopeptidases." IUCrJ 7, no. 1 (2020): 18–29. http://dx.doi.org/10.1107/s2052252519013848.

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Tannerella forsythia is an oral dysbiotic periodontopathogen involved in severe human periodontal disease. As part of its virulence factor armamentarium, at the site of colonization it secretes mirolysin, a metallopeptidase of the unicellular pappalysin family, as a zymogen that is proteolytically auto-activated extracellularly at the Ser54–Arg55 bond. Crystal structures of the catalytically impaired promirolysin point mutant E225A at 1.4 and 1.6 Å revealed that latency is exerted by an N-terminal 34-residue pro-segment that shields the front surface of the 274-residue catalytic domain, thus p
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Eskan, Mehmet A., George Hajishengallis, and Denis F. Kinane. "Differential Activation of Human Gingival Epithelial Cells and Monocytes by Porphyromonas gingivalis Fimbriae." Infection and Immunity 75, no. 2 (2006): 892–98. http://dx.doi.org/10.1128/iai.01604-06.

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ABSTRACT Humans develop periodontitis in response to challenge by microbial dental plaque. Inflammation begins after perturbation of gingival epithelial cells by subgingival bacteria interacting through pattern-recognition receptors, including the Toll-like receptors (TLR). Porphyromonas gingivalis is a major periodontopathogen that interacts with epithelial cells through its cell surface fimbriae (FimA), leading to colonization and/or invasion. Previous work by our group has established membrane CD14 as an essential coreceptor for TLR2-mediated activation of transfected cell lines by P. gingi
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Al-Rawi, Natheer, and Farah Al-Marzooq. "The Relation between Periodontopathogenic Bacterial Levels and Resistin in the Saliva of Obese Type 2 Diabetic Patients." Journal of Diabetes Research 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/2643079.

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This study aims to investigate the relation between resistin and periodontopathogenic bacterial levels in the saliva of obese adults compared to healthy control and to examine whether salivary resistin can serve as a biomarker of type 2 diabetes in obese patients. A total of 78 saliva samples were collected from patients attending to the University Dental Hospital, Sharjah, UAE. The patients were divided into three equal groups: obese diabetics, obese nondiabetics, and nonobese nondiabetic control. Salivary resistin was measured using ELISA. The levels of bacterial species associated with peri
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Beltran, Julián F., SM Viafara-Garcia, Alberto P. Labrador, and Johan Basterrechea. "The Role of Periodontopathogens and Oral Microbiome in the Progression of Oral Cancer. A Review." Open Dentistry Journal 15, no. 1 (2021): 367–76. http://dx.doi.org/10.2174/1874210602115010367.

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Chronic periodontal disease and oral bacteria dysbiosis can lead to the accumulation of genetic mutations that eventually stimulate Oral Squamous Cell Cancer (OSCC). The annual incidence of OSCC is increasing significantly, and almost half of the cases are diagnosed in an advanced stage. Worldwide there are more than 380,000 new cases diagnosed every year, and a topic of extensive research in the last few years is the alteration of oral bacteria, their compositional changes and microbiome. This review aims to establish the relationship between bacterial dysbiosis and OSCC. Several bacteria imp
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Anis Irmawati, Mohammad Iqbal, Wilson Sukandar, et al. "Potential of pomegranate mouthwash in inhibiting periodontopathogens bacteria development as alternative to halitosis therapy: A review." World Journal of Advanced Research and Reviews 20, no. 3 (2023): 532–39. http://dx.doi.org/10.30574/wjarr.2023.20.3.2466.

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Background: Halitosis is unpleasant odors originating from the oral cavity caused by metabolic waste of periodontopathogens bacteria in the form of volatile sulphur compounds (VSCs). According to Riskesdas 2018, the oral health prevalence in Indonesia reached 57.6%. Doctors recommend using a mouthwash made from chlorhexidine. However, it is less effective because it can cause various side effects. The alternative treatments using herbal ingredients using pomegranate. This literature review aim is to analyze the potential and mechanism of pomegranate mouthwash as an alternative to halitosis the
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Kulik, E. M., K. Lenkeit, S. Chenaux, and J. Meyer. "Antimicrobial susceptibility of periodontopathogenic bacteria." Journal of Antimicrobial Chemotherapy 61, no. 5 (2008): 1087–91. http://dx.doi.org/10.1093/jac/dkn079.

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Anis, Irmawati, Iqbal Mohammad, Sukandar Wilson, et al. "Potential of pomegranate mouthwash in inhibiting periodontopathogens bacteria development as alternative to halitosis therapy: A review." World Journal of Advanced Research and Reviews 20, no. 3 (2023): 532–39. https://doi.org/10.5281/zenodo.12740084.

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<strong>Background</strong>: Halitosis is unpleasant odors originating from the oral cavity caused by metabolic waste of periodontopathogens bacteria in the form of volatile sulphur compounds (VSCs). According to Riskesdas 2018, the oral health prevalence in Indonesia reached 57.6%. Doctors recommend using a mouthwash made from chlorhexidine. However, it is less effective because it can cause various side effects. The alternative treatments using herbal ingredients using pomegranate. This literature review aim is to analyze the potential and mechanism of pomegranate mouthwash as an alternative
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Sriram, Gopu, Vaishali Prakash Natu, Intekhab Islam, et al. "Innate Immune Response of Human Embryonic Stem Cell-Derived Fibroblasts and Mesenchymal Stem Cells to Periodontopathogens." Stem Cells International 2016 (2016): 1–15. http://dx.doi.org/10.1155/2016/8905365.

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Periodontitis involves complex interplay of bacteria and host immune response resulting in destruction of supporting tissues of the tooth. Toll-like receptors (TLRs) play a role in recognizing microbial pathogens and eliciting an innate immune response. Recently, the potential application of multipotent stem cells and pluripotent stem cells including human embryonic stem cells (hESCs) in periodontal regenerative therapy has been proposed. However, little is known about the impact of periodontopathogens on hESC-derived progenies. This study investigates the effects of heat-killed periodontopath
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Wada, Erika, Chiharu Ito, Mai Shinohara, et al. "Prunin Laurate Derived from Natural Substances Shows Antibacterial Activity against the Periodontal Pathogen Porphyromonas gingivalis." Foods 13, no. 12 (2024): 1917. http://dx.doi.org/10.3390/foods13121917.

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Periodontal disease is an inflammatory disease caused by infection with periodontopathogenic bacteria. Oral care is essential to prevent and control periodontal disease, which affects oral and systemic health. However, many oral hygiene products currently on the market were developed as disinfectants, and their intense irritation makes their use difficult for young children and older people. This study investigated the antibacterial effects of prunin laurate (Pru-C12) and its analogs on periodontopathogenic bacteria, Porphyromonas gingivalis (P. gingivalis). Pru-C12 and its analogs inhibited i
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Yusoff, Mohamad Ezany, Dr Ruhil Hayati Hamdan, Prof Madya Dr Haslina Taib, Dr Tan Li Peng, Professor Dr Maizan Mohamed, and Prof Madya Dr Rumaizi Shaari. "Overview of Gram-negative anaerobic pathogens associated with periodontal disease: A review." Asian Journal of Medicine and Biomedicine 8, no. 2 (2024): 98–110. https://doi.org/10.37231/ajmb.2024.8.2.761.

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Periodontal disease is a polymicrobial disease which initiation is by the presence and propagation of bacterial infections in dental biofilm. Gram-negative anaerobic bacteria were reported as the most prevalent oral bacteria associated with periodontitis. The periodontopathogens may destruct the periodontal tissue of the host directly or indirectly via inflammatory reaction. Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Tanerella forsythia, Prevotella intermedia, Treponema denticola and Campylobacter rectus are Gram-negative anaerobic bacteria which
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Munteanu, Ioana R., Ruxandra E. Luca, Marius Mateas, et al. "The Efficiency of Photodynamic Therapy in the Bacterial Decontamination of Periodontal Pockets and Its Impact on the Patient." Diagnostics 12, no. 12 (2022): 3026. http://dx.doi.org/10.3390/diagnostics12123026.

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Research in the field of periodontal disease continues to focus on disease-associated microorganisms, as the microbial plaque and the host immune responses are considered to be important causative factors, that are highly responsible for the progression of this disease. The purpose of this article is to compare the reduction in the number of specific periodontopathogens in two test groups according to different therapeutic approaches in periodontal disease and to show possible differences. This article is based on a prospective clinical study involving eighteen subjects with forty-four average
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Wilson, Michael, Krisanavane Reddi, and Brian Henderson. "Cytokine-inducing components of periodontopathogenic bacteria." Journal of Periodontal Research 31, no. 6 (1996): 393–407. http://dx.doi.org/10.1111/j.1600-0765.1996.tb00508.x.

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Fletcher, J., K. Reddi, S. Poole, et al. "Interactions between periodontopathogenic bacteria and cytokines." Journal of Periodontal Research 32, no. 1 (1997): 200–205. http://dx.doi.org/10.1111/j.1600-0765.1997.tb01406.x.

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Slazhneva, E. S., E. A. Tikhomirova, and V. G. Atrushkevich. "Periodontopathogens: a new view. Systematic review. Part 2." Pediatric dentistry and dental profilaxis 20, no. 2 (2020): 160–67. http://dx.doi.org/10.33925/1683-3031-2020-20-2-160-167.

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Relevance. The modern view of periodontitis as a dysbiotic disease that occurs as a result of changes in the microbial composition of the subgingival region is considered in a systematic review.Purpose. To study a new paradigm of development of generalized periodontitis.Materials and methods. Randomized controlled trials (RCTS) were selected for the study, including cluster RCTS, controlled (non-randomized) microbiological and clinical studies of the oral microbiome in adult patients with generalized periodontitis over the past 10 years.Results. The transition from a symbiotic microflora to a
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Meyer, D. H., K. P. Mintz, and P. M. Fives-Taylor. "Models of Invasion of Enteric and Periodontal Pathogens Into Epithelial Cells: A Comparative Analysis." Critical Reviews in Oral Biology & Medicine 8, no. 4 (1997): 389–409. http://dx.doi.org/10.1177/10454411970080040301.

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Bacterial invasion of epithelial cells is associated with the initiation of infection by many bacteria. To carry out this action, bacteria have developed remarkable processes and mechanisms that co-opt host cell function and stimulate their own uptake and adaptation to the environment of the host cell. Two general types of invasion processes have been observed. In one type, the pathogens (e.g., Salmonella and Yersinia spp.) remain in the vacuole in which they are internalized and replicate within the vacuole. In the other type, the organism (e.g., Actinobacillus actinomycetemcomitans, Shigella
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Pfitzner, Anne, Bernd W. Sigusch, Volker Albrecht, and Eike Glockmann. "Killing of Periodontopathogenic Bacteria by Photodynamic Therapy." Journal of Periodontology 75, no. 10 (2004): 1343–49. http://dx.doi.org/10.1902/jop.2004.75.10.1343.

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Musa, Wahidatunur, Nurulhuda Mohd, Zamirah Zainal-Abidin, Mazlina Mohd Said, and Badiah Baharin. "Antibacterial Activity of Phenolic Compounds in Olive Oil Extracts on Periodontopathogenic Oral Bacteria." Archives of Orofacial Sciences 17, Supp. 1 (2022): 21–33. http://dx.doi.org/10.21315/aos2022.17s1.oa01.

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Phenolic compounds are secondary metabolites of plants metabolism and can be found in olive oil. They exhibit antimicrobial activity towards both gram-positive and gram-negative bacteria. However, little is known about the antibacterial activity of the compounds towards periodontopathogens. The study aimed to investigate the potential of these compounds as antibacterial agents towards pathogens, specifically Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Fusobacterium nucleatum. Phenolic compounds were extracted from extra virgin olive oil (EVOO) through liquid-liquid sepa
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Martu, Maria Alexandra, Sorina Mihaela Solomon, Irina Georgeta Sufaru, et al. "Study on the Prevalence of Periodontopathogenic Bacteria in Serum and Subgingival Bacterial Plaque in Patients with Rheumatoid Arthritis." Revista de Chimie 68, no. 8 (2017): 1946–50. http://dx.doi.org/10.37358/rc.17.8.5798.

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The purpose of this study was to detect bacterial periodontal DNA from subgingival dental plaque and serum in patients affected by rheumatoid arthritis and periodontitis. The study group included 19 patients with periodontitis and refractory rheumatoid arthritis. The patients were clinically examined and diagnosed and the bacterial DNA was detected in the subgingival bacterial plate and serum by PCR. Severe chronic periodontitis was the most commonly diagnosed (42.2%). The DNA of periodontopathogenic bacteria was detected 100% in subgingival plate samples, and in serum samples it was identifie
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Villafuerte, K. R. V., C. J. H. Martinez, A. V. V. Nobre, L. P. Maia, and C. Tirapelli. "What are microbiological effects of the adjunctive use of probiotics in the treatment of periodontal diseases? A systematic review." Beneficial Microbes 12, no. 4 (2021): 307–19. http://dx.doi.org/10.3920/bm2020.0143.

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Probiotics have aroused great interest as an adjunctive treatment to periodontal therapy, due to the frequent colonisation by periodontopathogens after therapy. The aim of this systematic review was to analyse in the scientific literature, evidence of the microbiological effects of probiotics as an adjunct to periodontal therapy in the treatment of periodontal diseases (PD). Only randomised controlled trials (RCT), evaluating the microbiological effect of probiotics as an adjunct to periodontal therapy. The authors conducted a search in PubMed/MEDLINE, LILACS, ScienceDirect, Web of Science and
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Ginnatulina, Sofya I. "In-vitro modeling of a biofilm of endoparodontal focus of infection." Aspirantskiy Vestnik Povolzhiya 21, no. 1-2 (2021): 64–68. http://dx.doi.org/10.55531/2072-2354.2021.21.1.64-68.

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The development of the model of endoparodontal lesion in vitro is necessary due to the lack of the method for creating a biofilm of endodonto- and periodontopathogenic bacteria in vitro with the reconstruction of communication ways between the endodontium and the periodontium. We have proposed the method, the technical result of which is the maximal reconstruction of a multi-species mixed bacterial biofilm in tooth tissues in the environment similar to in vivo conditions, with the possibility of processing root canals and periodontal pockets in vitro. The proposed model is effective for the cu
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Tellapragada, Chaitanya, Vandana Kalwaje Eshwara, Shashidhar Acharya, et al. "Prevalence of Clinical Periodontitis and Putative Periodontal Pathogens among South Indian Pregnant Women." International Journal of Microbiology 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/420149.

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In view of recent understanding of the association of periodontal infections and adverse pregnancy outcomes, the present investigation was undertaken to study the periodontal infections among 390 asymptomatic pregnant women and to find an association of bacterial etiologies with the disease. Prevalence of gingivitis was 38% and clinical periodontitis was 10% among the study population. Subgingival plaque specimens were subjected to multiplex PCR targeting ten putative periodontopathogenic bacteria. Among the periodontitis group, high detection rates ofPorphyromonas gingivalis(56%),Prevotella n
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