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Dissertations / Theses on the topic 'Peripheral arteries disease'

Author: Grafiati

Published: 29 March 2025

Last updated: 31 July 2025

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1

Lewis, M. H. "Peripheral arterial disease from aetiology to surgical management." Thesis, University of South Wales, 2013. https://pure.southwales.ac.uk/en/studentthesis/peripheral-arterial-disease-from-aetiology-to-surgical-management(7defd31a-6995-4fc7-9302-2fced42b5982).html.

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The work presented includes over thirty peer reviewed published manuscripts based on studies undertaken during my surgical career. As Principal Investigator, I led the study conception/design/data acquisition/analysis/interpretation and was involved with writing the final drafts of all manuscripts prior to their formal submission to high impact factor peer-reviewed specialist journals. The thesis is divided into subsections reflecting my development and different interests within surgery. The subsections start with my learning basic research principles, moving onto clinical problem solving in

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2

Christman, Sharon Klopfenstein. "Intervention to slow progression of peripheral arterial disease." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1054059524.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xiii, 123 p.; also includes graphics (some col.). Includes bibliographical references (p. 114-123). Available online via OhioLINK's ETD Center

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3

Ögren, Mats. "Vascular morbidity and mortality in men with non-invasively detected peripheral arterial disease results from the prospective population study "Men born in 1914" /." Lund : Dept. of Community Health Sciences and the Dept. of Clinical Physiology, Malmö General Hospital, Lund University, 1994. http://catalog.hathitrust.org/api/volumes/oclc/39693808.html.

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4

Hou, Xiang-Yu. "Exercise performance and mitochondrial function in peripheral arterial disease." Thesis, Queensland University of Technology, 2002. https://eprints.qut.edu.au/36778/1/36778_Digitised%20Thesis.pdf.

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Peripheral arterial disease (PAD) is an atherosclerotic disease in the peripheral arteries, which reduces blood supply to the lower extremities. Intermittent claudication is the symptom that develops early in PAD patients and is accompanied by the haemodynamic finding of a fall in systolic blood pressure at the ankles following exercise. In PAD patients, exercise performance is not well correlated with haemodynamic measurements and other mechanisms have been suggested to account for the impairment. There have been reports about the impaired mitochondrial metabolism (eg, decreased activities of

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5

Barker, Glenn A. "Carbohydrate metabolism in peripheral arterial disease." Thesis, Queensland University of Technology, 2003. https://eprints.qut.edu.au/36790/1/36790_Digitised%20Thesis.pdf.

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Peripheral arterial disease results in varying degrees of functional disability. Although principally a disease of the vascular tree, evidence demonstrates a significant contribution from metabolic alterations within ischaemically affected skeletal muscle. This thesis was concerned with better characterising the nature of these metabolic alterations, and their contribution to the functional disability in PAD patients. It also examined the efficacy of dietary carbohydrate supplementation as a therapeutic intervention in PAD. The activity of the pyruvate dehydrogenase complex (PDH) is an impo

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6

Insall, R. L. "Pulse waveforms and transit time from photoelectric plethysmography in the diagnosis of peripheral vascular disease." Thesis, University of Newcastle Upon Tyne, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309069.

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7

Sanderson, Brad E. "Supervised stationary cycling versus supervised treadmill-walking for periperal arterial disease /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18988.pdf.

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8

Collins, Patrick William Hugh. "Assessing the severity of lower limb ischaemia and the thrombo-inflammatory response to surgery and exercise in peripheral arterial disease." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources. Restricted contains 3rd party material and therefore cannot be made available electronically until Jan. 1, 2012, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=53369.

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Thesis (M.D.)--Aberdeen University, 2008.<br>With: Surgical revascularisation in patients with severe limb ischaemia induces a pro-thrombotic state / P. Collins ... et al. Platelets. 2006: 17(5), 311-317. With: A preliminary study on the effects of exercising to a maximum walking distance on platelet and endothelial function in patients with intermittent claudication / P. Collins ... et. Eur. J. Vasc. Endovasc. Surg. 2006: 31, 266-273. Includes bibliographical references.

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9

Gallagher, Ryan Robert. "THE IMPACT OF OUTWARD REMODELING ON VASODILATION IN SKELETAL MUSCLE RESISTANCE ARTERIES." DigitalCommons@CalPoly, 2012. https://digitalcommons.calpoly.edu/theses/914.

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Peripheral arterial occlusive disease (PAOD) is an ischemic disease characterized by narrowing of the peripheral arteries due to the accumulation of atherosclerotic plaque in the inner lining of the vessels, which disrupts blood flow to downstream tissues. Blood can be redirected into collateral vessels, natural bypasses around arterial occlusions, causing shear-induced outward remodeling of the vessels. The enlarged vessels facilitate transfer of increased blood flow to downstream tissues. The remodeling process, however, may impair vasodilation, which in turn may cause or contribute to inter

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10

Wong, Shen. "The measurement of platelet function in response to 3 common antiplatelet regimens in patients with peripheral occlusive arterial disease." Thesis, The University of Sydney, 2004. https://hdl.handle.net/2123/27942.

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Background: Anti-platelet therapy reduces vascular complications in patients with peripheral occlusive arterial disease (POAD) with aspirin the most commonly prescribed agent. However, aspirin resistance can be observed in patients who suffer clinical thromboembolic events, or have persistent platelet activity despite regular aspirin treatment. The clinical benefits of clopidogrel or combination aspirin and clopidogrel therapy may be due to superior platelet inhibition or the inhibition of platelets in aspirin resistant patients. Aim: To investigate the effects of aspirin, clopidogrel

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11

Cheung, Yiu-fai, and 張耀輝. "An analysis of the determinants of peripheral conduit arterial stiffness in children and teenagers in health and disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B29761815.

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12

Sigvant, Birgitta. "Epidemiological aspects of peripheral arterial disease." Stockholm : Department of Molecular Medicine and Surgery, Karolinska Institutet, 2009. http://diss.kib.ki.se/2009/978-91-7409-670-5/.

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13

Askew, Christopher D. "Exercise intolerance in peripheral arterial disease." Thesis, Queensland University of Technology, 2002. https://eprints.qut.edu.au/15869/1/Christopher_Askew_Thesis.pdf.

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Patients with Peripheral Arterial Disease have a reduced capacity for exercise, the exact causes of which are poorly understood. This thesis investigated alternative testing procedures that aim to provide a more complete and precise description of the exercise capacities of these patients. Furthermore, the potential roles of gastrocnemius muscle fibre morphometry, capillary supply and glycogen stores in the exercise tolerance of PAD patients were studied. Study one aimed to determine the effect of test repetition on maximal exercise performance and test-to-test variability in PAD patien

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14

Askew, Christopher D. "Exercise intolerance in peripheral arterial disease." Queensland University of Technology, 2002. http://eprints.qut.edu.au/15869/.

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Patients with Peripheral Arterial Disease have a reduced capacity for exercise, the exact causes of which are poorly understood. This thesis investigated alternative testing procedures that aim to provide a more complete and precise description of the exercise capacities of these patients. Furthermore, the potential roles of gastrocnemius muscle fibre morphometry, capillary supply and glycogen stores in the exercise tolerance of PAD patients were studied. Study one aimed to determine the effect of test repetition on maximal exercise performance and test-to-test variability in PAD patien

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15

Bauer, Timothy Alan. "Oxygen uptake kinetics in peripheral arterial disease." Diss., Manhattan, Kan. : Kansas State University, 2005. http://hdl.handle.net/2097/125.

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16

Welten, Gijs. "Prognosis of patients with peripheral arterial disease." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/13949.

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17

Bertanha, Matheus [UNESP]. "Estruturação ex-vivo de vasos sanguíneos a partir da diferenciação de células tronco de coelhos." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/88060.

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Made available in DSpace on 2014-06-11T19:23:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-10-04Bitstream added on 2014-06-13T18:50:20Z : No. of bitstreams: 1 bertanha_m_me_botfm.pdf: 4042528 bytes, checksum: cdc59622a6658e29d1187a28f3ccdba1 (MD5)<br>Ministério da Saúde<br>O cultivo de células tronco (CT) e a descoberta de técnicas que promovem a diferenciação tecidual apontam para novos domínios da medicina: a terapia celular e a engenharia de tecidos (ET). As limitações da medicina atual encontram na ET uma nova possibilidade terapêutica, com tratamentos regenerativos ou substi

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18

Widener, Jeanne Malcom. "Disease Severity and Disability in Persons with Peripheral Arterial Disease." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1204652303.

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19

Cleanthis, T. M. "Platelet function in lower limb peripheral arterial disease." Thesis, University of Newcastle upon Tyne, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432504.

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20

Koelemay, Mark Jan Wilhelm. "Non-invasive assessment of peripheral arterial occlusive disease." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2001. http://dare.uva.nl/document/85398.

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21

Christman, Sharon K. "Intervention to slow progression of peripheral arterial disease." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1054059524.

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22

Archer, Colleen E. "Accommodating pain-free exercise therapy for peripheral arterial disease." [Gainesville, Fla.] : University of Florida, 2006. http://purl.fcla.edu/fcla/etd/UFE0015221.

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23

Aly, Sayed Awad Abdel Fattah. "Duplex ultrasound in the assessment of peripheral arterial disease." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299775.

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24

O'Brien, Claire Margaret. "Antioxidants and peripheral arterial disease : a case-control study." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428704.

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25

Maan, Neeti. "i-Nitrite Therapy for Treatment of Peripheral Arterial Disease." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1339162099.

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26

Donnan, Peter Thomas. "A study of risk factors for peripheral arterial disease." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/19694.

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This thesis set out to consider risk factors, in isolation and in combination, for symptomatic and asymptomatic Peripheral Arterial Disease (PAD), which unlike Coronary Heart Disease, has not been undertaken in a random sample from the general population aged 55-74 years. The results showed that the risk factors in relationship to the Ankle Brachial Pressure Index (ABPI), an indicator of the extent of asymptomatic and symptomatic PAD, differed for men and for women and for smokers and non-smokers. In women smoking was the main risk factor, while blood viscosity and fibrinogen although univaria

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27

Morsey, Hesham. "Ischaemia reperfusion injury in patients with peripheral arterial occlusive disease." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.516556.

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28

Triola, Laura Walter. "Peripheral Arterial Disease Screening of an Underserved High Risk Population." UNF Digital Commons, 2006. http://digitalcommons.unf.edu/etd/333.

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Disparity in access to health care and preventive services places a heavier burden of morbidity on those with limited access and resources. Underserved populations with decreased access to appropriate health screening and therapeutic interventions often present with increased risks for peripheral arterial disease. Some patients with peripheral arterial disease are asymptomatic and may defer treatment while others present with occlusive disease requiring immediate therapy. Delaying diagnosis and treatment reduces quality of life and functional status. The prevalence of peripheral arterial disea

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29

Lu, Liya. "Association between active smoking, secondhand smoke and peripheral arterial disease." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8059/.

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Worldwide, cardiovascular disease (CVD) is the leading cause of death. It is widely accepted that both active smoking and exposure to secondhand smoke (SHS) are associated with CVD. About 20% of the global population smoke tobacco or tobacco-related products. The global prevalence of smoking is increasing, although it is decreasing in some high-income and upper middle-income countries. Globally, about a third of adults and 40% children are regularly exposed to SHS. According to the World Health Organisation (WHO), only 16% of the global population is protected by a comprehensive smoke-free leg

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30

Siggberg, Ida. "Lipid Markers in Men and Women with Peripheral Arterial Disease." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-93344.

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Introduction Lipoprotein(a) (Lp(a)) and oxidized LDL (oxLDL) are circulating lipoproteins known to promote development of atherosclerosis. LDL can be oxidized in several ways, including enzymatic oxidation by myeloperoxidase (MPO). The knowledge regarding these biomarkers in men and women with different presentations of peripheral arterial disease (PAD) is scarce. Aim To investigate sex differences in plasma levels of MPO, Lp(a) and oxLDL in patients undergoing open vascular surgery. A secondary aim was to elucidate how indication for surgery, risk factors and comorbidity influenced the levels

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31

Tzoulaki, Ioanna. "Inflammation and haemostasis in the development and progression of peripheral atherosclerotic disease." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/2148.

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Peripheral arterial disease (PAD) defines atherosclerotic disease of the arteries to the legs. PAD begins early in life and remains asymptomatic over long periods. The ankle brachial index (ABI) is an important diagnostic test which can identify asymptomatic individuals and serve as a good marker of the underlying peripheral and systemic atherosclerosis. Recent advances in vascular biology proposed a role of inflammatory and haemostatic mechanisms in atherosclerotic disease. Although inflammatory and haemostatic markers have been associated with coronary atherosclerosis in large scale epidemio

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32

Burdess, Anne. "Role of inflammation and platelet activation in the adverse cardiovascular outcomes of patients undergoing surgery for critical limb ischaemia." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9539.

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Increased platelet activation and inflammation play a key role in atherothrombosis. Patients with peripheral arterial disease are at increased risk of adverse cardiovascular events, particularly at the time of surgery. We postulated that the increase in peri-operative cardiovascular events is mediated by increased platelet activation and inflammation. We hypothesized that peri-operative dual anti-platelet therapy would improve biomarkers of atherothrombosis without causing unacceptable bleeding in patients undergoing surgery for critical limb ischaemia (CLI). Prior to interventional study, I v

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33

Stoffers, Henri Elise Johannes Hubertus. "Peripheral arterial occlusive disease prevalence and diagnostic management in general practice /." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1995. http://arno.unimaas.nl/show.cgi?fid=7926.

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34

Dickinson, Karen Joanna. "The regulation of platelet function in patients with peripheral arterial disease." Thesis, University of Leeds, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598024.

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Platelets play an important role in the pathogenesis of atherothrombosis and, as such, measuring platelet dysfunction in patients with peripheral arterial disease (PAD) may be a useful prognostic marker for future cardiovascular events. Detecting increased platelet activity but also reduced platelet inhibition is important in the management of these patients. Prediction of cardiovascular risk could allow tailored anti-platelet regimens in high risk groups. Dissection of platelet function in patients with PAD could allow cardiovascular risk stratification and the aim of this thesis was to devel

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35

Cunningham, Margaret. "Psychological factors associated with walking in patients with Peripheral Arterial Disease." Thesis, University of Stirling, 2010. http://hdl.handle.net/1893/3040.

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Objectives This thesis aimed to explore psychological factors associated with walking behaviour in patients with Peripheral Arterial Disease, within the framework of Leventhal et al’s (1998) Common-sense Model of Self-regulation of Health and Illness. The objective was to identify psychological factors which could be modified to increase walking behaviour in these patients. Method A series of three studies were conducted to achieve these aims. The first study was an exploratory qualitative study, to explore the illness and treatment beliefs and walking behaviour of patients with intermittent c

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36

Khan, Shaukat Nawaz. "Risk factor stratification of peripheral arterial disease in the United Kingdom." Thesis, University of Newcastle Upon Tyne, 2005. http://hdl.handle.net/10443/223.

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Objective: To document the patient characteristics, primary care and hospital management and QoL in patients with intermittent claudication in the United Kingdom. Also to determine the appropriate use of prophylactic therapy, to determine markers of high and low risk and to suggest approaches to optimise the management of peripheral arterial disease. Methods: 474 patients were recruited from 23 centres across the United Kingdom. Data was collected at baseline and at six months and risk factors profile was analysed. Results: Symptomatic disease is more prevalent in men and those above 60. A hig

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37

Bennett, Philip Christopher. "Peripheral arterial disease amongst minority ethnic groups in the United Kingdom." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4726/.

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Peripheral arterial disease (PAD), a common manifestation of atherosclerosis, is an important healthcare problem with considerable morbidity and mortality. Intermittent claudication (IC) is the commonest symptomatic manifestation of this disease. This thesis investigates the prevalence of PAD in South Asians (people originating from India, Pakistan and Bangladesh) and Blacks (Black African, Black Caribbean) and makes ethnic comparisons of its associations with traditional cardiovascular risk factors, inflammatory and haemostatic biomarkers and markers of angiogenesis in these ethnic groups. Th

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38

Wästgård, Rebecka. "Peripheral arterial disease (PAD) - A descriptive cost study with gender analyses." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-48543.

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39

Yu, S. R. "Cytoprotective mechanisms of erythropoietin and erythropoietin derivatives in peripheral arterial disease." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1458006/.

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A third of patients with critical limb ischaemia (CLI) eventually require amputation. Inconsistencies between successful revascularisation and functional outcomes exist, and underlying musculopathy in CLI patients has been identified. Erythropoietin (EPO) has tissue-protective effects in response to ischaemic injury, but its clinical use is often precluded by thromboembolic side effects. Non-haematopoietic EPO-derivatives have been designed to retain only tissueprotective functions of EPO. We hypothesised that ARA-290 (EPO-derivative) may have tissue-protective potential that could represent a

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40

Rockley, Mark. "Intraoperative Physiologic Monitoring During Endovascular Revascularization for Atherosclerotic Peripheral Arterial Disease." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/41149.

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Peripheral vascular disease (PVD) is defined by insufficient blood flow to limbs and can result in pain, gangrene, and amputation. Minimally invasive angioplasty treatments for PVD are common but suffer from high failure rates. We conducted three studies: 1) a systematic review to describe methods of intraoperative blood flow assessment; 2) a retrospective cohort study to describe the correlation between outpatient blood flow assessment and clinical outcomes; and 3) a prospective observational study to describe the reliability and association between intraoperative blood flow assessment and

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41

Smith, Felicity Barbara. "Role of fibrinogen and fibrin D-dimer in peripheral arterial disease." Thesis, University of Glasgow, 1998. http://theses.gla.ac.uk/30947/.

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This thesis is composed of two studies. The principal aim of the first study, the Sites of Atheroma Study, was to determine whether plasma fibrinogen, fibrin D-dimer and other haemostatic factors (von Willebrand Factor and plasminogen activator inhibitor - type I) were related to the angiographic site and severity of atherosclerosis in the arteries of the lower limb. The principal aim of the second study, the Prognostic Study of Intermittent Claudication, was to determine whether plasma fibrinogen, fibrin D-dimer and other haemostatic factors (von Willebrand Factor and tissue plasminogen activ

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42

Venâncio, Luciene de Souza [UNESP]. "Efeitos da suplementação vitamínica de ácido fólico sobre a concentração de homocisteína e marcadores de inflamação em indivíduos portadores de doença arterial periférica." Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/100381.

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Made available in DSpace on 2014-06-11T19:30:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-12-15Bitstream added on 2014-06-13T20:00:57Z : No. of bitstreams: 1 venancio_ls_dr_botfm.pdf: 1176932 bytes, checksum: cb3091aa4e4bde7e6ddd7327173e8782 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Estudos epidemiológicos mostraram que a prevalência de doença arterial periférica (DAP) é alta e tem como fator etiológico principal a aterosclerose. Os fatores de risco para o desenvolvimento da aterosclerose são bastante conhecidos, e nos últimos anos, foi identifica

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43

Woodburn, Kenneth Robert. "Blood rheology and thrombotic mediators in peripheral arterial disease and revascularisation surgery." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/20877.

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Rheological parameters and levels of plasma fibrinogen, cross-linked fibrin degradation products (FDP's), von Willebrand Factor antigen (vWF), factor VII, and Plasminogen Activator Inhibitor (P.A.I.), were found to be altered in 219 patients with occlusive arterial disease undergoing revascularisation procedures, when compared with an age-matched random population sample. Elevated levels of some of these potential thrombotic mediators are associated with the angiographic severity of arterial disease on univariate analysis, while multivariate analysis indicates that log (FDP) is independently r

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44

Hywood, Jack. "Assessment of the angiogenic potential of induced endothelial cells derived from patients with peripheral arterial disease." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23658.

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Peripheral arterial disease (PAD) and coronary artery disease (CAD) are major causes of mortality and morbidity globally [1–4]. While endovascular or surgical revascularisation procedures represent the gold standard therapy for severe atherosclerotic disease a substantial subset of patients are unsuitable for these interventions due to pre-existing morbidity or an extremely calcified vasculature [2, 5–10]. Furthermore, restenosis of vessels represents a not uncommon outcome of these procedures [11]. As such, there is a significant patient population refractory to existing medical and surgical

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45

Park, Kwijun. "Therapeutic potential of atrial natriuretic peptide administration on peripheral arterial diseases." Kyoto University, 2008. http://hdl.handle.net/2433/135849.

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46

Chastaingt, Lucie. "Épidémiologie descriptive & facteurs pronostiques de l’artériopathie oblitérante des membres inférieurs dans les populations négligées." Electronic Thesis or Diss., Limoges, 2024. http://www.theses.fr/2024LIMO0117.

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L’artériopathie oblitérante des membres inférieurs (AOMI) est une pathologie cardio-vasculaire dont la morbi mortalité continue à croitre. Malgré cela, elle reste une pathologie négligée parmi les maladies cardio-vasculaires, car ne recevant pas un traitement médical optimal. Et au sein même de l’AOMI, certaines populations restent négligées par la recherche épidémiologique, alors même qu’elles semblent être de plus en plus concernées par l’AOMI. L’objectif général de cette thèse est donc d’étudier l’épidémiologie de l’AOMI et son évolution dans le contexte de certaines populations particulièr

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47

Kock, Marcus Cornelius Johannes Maria. "Diagnostic imaging of peripheral arterial disease with multi-detector row computed tomography angiography." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10509.

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48

Lee, Kui-Joo. "The detection of double product break point in individuals with peripheral arterial disease." Virtual Press, 2000. http://liblink.bsu.edu/uhtbin/catkey/1178340.

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Peripheral arterial disease (PAD) is a common manifestation of stenoses and occlusions of the arteries of the lower extremities. Clinically, PAD is an important effect on functional ability, and quality of life because symptomatic patients are typically able to walk less than one to three blocks before rest is required.The double product break point (DPBP), also defined as the oxygen consumption at which the first portion of nonlinear increase in rate pressure product (systolic blood pressure X heart rate) begins has been identified to determine the anaerobic threshold during exercise test. Th

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49

O'Donnell, M. E. "The Effects of Cilostazol on Inflammatory Response in Patients With Peripheral Arterial Disease." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501396.

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50

Robertson, Alan. "Allopurinol as a possible oxygen sparing agent during exercise in peripheral arterial disease." Thesis, University of Dundee, 2014. https://discovery.dundee.ac.uk/en/studentTheses/6d3e342c-d2fb-4cec-b678-082d1fb2e067.

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Patients with peripheral arterial disease (PAD) can only walk so far before they get leg pain (intermittent claudication) and have to stop. They are also at risk in the future of needing amputation of one of their limbs. Allopurinol is a new possible treatment for this condition as it has been shown in coronary arterial disease to prolong exercise before angina pain occurs. This is thought to be because allopurinol can both prevent oxygen wastage in tissues and prevent the formation of harmful oxidative stress. We hypothesised that allopurinol could prolong the time to leg pain in participants

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