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Journal articles on the topic 'Peripheral blood inflammatory cells (PBICs)'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Bories, Gael, Robert Caiazzo, Bruno Derudas, et al. "Impaired alternative macrophage differentiation of peripheral blood mononuclear cells from obese subjects." Diabetes and Vascular Disease Research 9, no. 3 (2011): 189–95. http://dx.doi.org/10.1177/1479164111430242.

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Visceral obesity is a chronic, low-grade inflammatory disease that predisposes people to the metabolic syndrome, type 2 diabetes and its cardiovascular complications. Adipose tissue is not a passive storehouse for fat, but an endocrine organ synthesizing and releasing a variety of bioactive molecules, some of which are produced by infiltrated immune-inflammatory cells including macrophages. Two different subpopulations of macrophages have been identified in adipose tissue: pro-inflammatory ‘classical’ M1 and anti-inflammatory ‘alternative’ M2 macrophages, and their ratio is suggested to influe

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Shulman, Iliya, Sergei Ogurcov, Alexander Kostennikov, et al. "Application of Autologous Peripheral Blood Mononuclear Cells into the Area of Spinal Cord Injury in a Subacute Period: A Feasibility Study in Pigs." Biology 10, no. 2 (2021): 87. http://dx.doi.org/10.3390/biology10020087.

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Peripheral blood presents an available source of cells for both fundamental research and clinical use. In our study, we have evaluated the therapeutic potential of peripheral blood mononuclear cells (PBMCs) excluding the preliminary sorting or mobilization of peripheral blood stem cells. We have evaluated the regenerative potential of PBMCs embedded into a fibrin matrix (FM) in a model of pig spinal cord injury. The distribution of transplanted PBMCs in the injured spinal cord was evaluated; PBMCs were shown to penetrate into the deep layers of the spinal cord and concentrate mainly in the gre

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Song, Xinqiang, Yu Zhang, Lijun Zhao, et al. "Analyzation of the Peripheral Blood Mononuclear Cells Atlas and Cell Communication of Rheumatoid Arthritis Patients Based on Single-Cell RNA-Seq." Journal of Immunology Research 2023 (August 12, 2023): 1–20. http://dx.doi.org/10.1155/2023/6300633.

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Background. Rheumatoid arthritis (RA) is a common chronic inflammatory autoimmune disease with a multifactorial etiology. Peripheral blood is the main channel of the immune system, and peripheral blood mononuclear cells (PBMCs) are the immune cells that initiate the autoimmune inflammatory process. However, there are few reports on the mechanisms of peripheral blood immunity in RA. Methods. ScRNA-seq was performed on four RA samples and integrated with single-cell transcriptome data from four healthy control samples downloaded from publicly available databases for analysis. Results. A total of

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Kaur, Kawaljit, Shahram Vaziri, Marcela Romero-Reyes, Avina Paranjpe, and Anahid Jewett. "Phenotypic and Functional Alterations of Immune Effectors in Periodontitis; A Multifactorial and Complex Oral Disease." Journal of Clinical Medicine 10, no. 4 (2021): 875. http://dx.doi.org/10.3390/jcm10040875.

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Survival and function of immune subsets in the oral blood, peripheral blood and gingival tissues of patients with periodontal disease and healthy controls were assessed. NK and CD8 + T cells within the oral blood mononuclear cells (OBMCs) expressed significantly higher levels of CD69 in patients with periodontal disease compared to those from healthy controls. Similarly, TNF-α release was higher from oral blood of patients with periodontal disease when compared to healthy controls. Increased activation induced cell death of peripheral blood mononuclear cells (PBMCs) but not OBMCs from patients

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Yadav, Brijesh, Narayan Prasad, Ravi Shanker Kushwaha, et al. "Urinary Mitochondrial DNA Induces an Inflammatory Response in Peripheral Blood Mononuclear Cells." Indian Journal of Transplantation 18, no. 2 (2024): 132–37. http://dx.doi.org/10.4103/ijot.ijot_94_23.

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Background: Mitochondria are semiautonomous cell organelles having its own nucleic acid. Mitochondrial DNA (Mt-DNA) remain in hypomethylated (CpG) state and impose an immunogenic response by binding to the toll-like receptor (TLR-9) through the NF-kB pathway. Innate immune cells recognize the hypomethylated pattern of mt-DNA and quickly trigger the innate immune response. The immunomodulatory effects of urinary mt-DNA derived from renal transplant recipients with COVID-19-associated acute kidney injury (AKI) have not been studied. Materials and Methods: Healthy donor peripheral blood mononucle

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Yin, Xuejiao, Yi Liu, Hongyan Tong та Liangshun You. "Pro-Inflammatory Monocytes As Key Effector Cells in Peripheral Circulatory Inflammatory Storms Driven By IFN-γ and IL-6 Pathways in Imcd". Blood 144, Supplement 1 (2024): 4685. https://doi.org/10.1182/blood-2024-207774.

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Objective: Dysfunctional cytokine-driven inflammatory storms in patients with idiopathic multicentric Castleman disease (iMCD) are a recurring issue affecting both symptoms and mortality, yet a thorough understanding of the involved immune cells remains incomplete. A comprehensive and detailed peripheral immune landscape is crucial for effectively treating iMCD. Design: We employed single-cell RNA sequencing of 150936 cells from a cohort of 19 individuals, including 15 iMCD patients with mild or severe disease, as well as 4 healthy controls. For validation, we also enrolled a second cohort of

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Krishnamoorthy, Rajapandiyan, Abdulraheem R. Adisa, Vaiyapuri Subbarayan Periasamy, Jegan Athinarayanan, Subash-Babu Pandurangan, and Ali A. Alshatwi. "Colonic Bacteria-Transformed Catechin Metabolite Response to Cytokine Production by Human Peripheral Blood Mononuclear Cells." Biomolecules 9, no. 12 (2019): 830. http://dx.doi.org/10.3390/biom9120830.

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Human gut microbes are a profitable tool for the modification of food compounds into biologically active metabolites. The biological properties of catechins have been extensively investigated. However, the bioavailability of catechin in human blood plasma is very low. This study aimed to determine the biotransformed catechin metabolites and their bioactive potentials for modulating the immune response of human peripheral blood mononuclear cells (PBMCs). Biotransformation of catechin was carried out using in-vitro gut microbial biotransformation method, the transformed metabolites were identifi

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Prasetio, Ardi, Luthfiana Mifta Syafitri, Adam Prabowo, Iffan Alif, and Aldan Nurichsan. "Priming of Mesenchymal Stem Cells for Enhanced Interleukin-10 Secretion via Conditioned Medium from Lipopolysaccharide-Activated Peripheral Blood Mononuclear Cells." International Journal of Cell and Biomedical Science 2, no. 5 (2024): 167–74. https://doi.org/10.59278/cbs.v2i5.39.

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Background: Mesenchymal stem cells (MSCs) are known for their immunomodulatory properties, particularly their ability to secrete anti-inflammatory cytokines such as interleukin-10 (IL-10). Enhancing the secretion of IL-10 by MSCs could have significant therapeutic potential for treating inflammatory diseases. Objective: This study aimed to prime the secretion of IL-10 by MSCs through the use of conditioned medium (CM) derived from lipopolysaccharide (LPS)-induced peripheral blood mononuclear cells (PBMCs). Methods: MSCs were isolated from Wharton’s Jelly and characterized using flow cytometry

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Szafran, Brittany, Jung Lee, Abdolsamad Borazjani, et al. "Characterization of Endocannabinoid-Metabolizing Enzymes in Human Peripheral Blood Mononuclear Cells under Inflammatory Conditions." Molecules 23, no. 12 (2018): 3167. http://dx.doi.org/10.3390/molecules23123167.

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Endocannabinoid-metabolizing enzymes are downregulated in response to lipopolysaccharide (LPS)-induced inflammation in mice, which may serve as a negative feedback mechanism to increase endocannabinoid levels and reduce inflammation. Increased plasma levels of the pro-inflammatory cytokine interleukin-6 (IL-6) and decreased fatty acid amide hydrolase (FAAH) activity in peripheral lymphocytes from individuals diagnosed with Huntington’s disease (HD) suggests that a similar negative feedback system between inflammation and the endocannabinoid system operates in humans. We investigated whether Cp

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Connolly, Peter H., Vincent J. Caiozzo, Frank Zaldivar, et al. "Effects of exercise on gene expression in human peripheral blood mononuclear cells." Journal of Applied Physiology 97, no. 4 (2004): 1461–69. http://dx.doi.org/10.1152/japplphysiol.00316.2004.

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Exercise leads to increases in circulating levels of peripheral blood mononuclear cells (PBMCs) and to a simultaneous, seemingly paradoxical increase in both pro- and anti-inflammatory mediators. Whether this is paralleled by changes in gene expression within the circulating population of PBMCs is not fully understood. Fifteen healthy men (18–30 yr old) performed 30 min of constant work rate cycle ergometry (∼80% peak O2 uptake). Blood samples were obtained preexercise (Pre), end-exercise (End-Ex), and 60 min into recovery (Recovery), and gene expression was measured using microarray analysis

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Small, Annabelle, Suzanne Cole, Jing J. Wang, Sunil Nagpal, Ling-Yang Hao, and Mihir D. Wechalekar. "Attenuation of the BTLA/HVEM Regulatory Network in the Circulation in Primary Sjögren’s Syndrome." Journal of Clinical Medicine 11, no. 3 (2022): 535. http://dx.doi.org/10.3390/jcm11030535.

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Primary Sjögren’s syndrome (SjS) is an inflammatory autoimmune disorder which targets the lacrimal and salivary glands, resulting in glandular dysfunction. Currently, the immune drivers of SjS remain poorly understood and peripheral biomarkers of disease are lacking. The present study therefore sought to investigate the immune cell constituents of the SjS peripheral blood, and to assess the role of the BTLA/HVEM/CD160 co-stimulatory network by characterizing expression within the periphery. Peripheral blood mononuclear cells (PBMCs) were isolated from whole blood of n = 10 patients with SjS an

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Nguyen, Doan, Vi Tran, Alireza Shirazian, Cruz Velasco-Gonzalez, and Ifeanyi Iwuchukwu. "Anti-inflammatory genes in PBMCs post-spontaneous intracerebral hemorrhage." Translational Neuroscience 12, no. 1 (2021): 58–66. http://dx.doi.org/10.1515/tnsci-2021-0003.

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Abstract Background Neuroinflammation is important in the pathophysiology of spontaneous intracerebral hemorrhage (ICH) and peripheral inflammatory cells play a role in the clinical evolution and outcome. Methodology Blood samples from ICH patients (n = 20) were collected at admission for 5 consecutive days for peripheral blood mononuclear cells (PBMCs). Frozen PBMCs were used for real-time PCR using Taqman probes (NFKB1, SOD1, PPARG, IL10, NFE2L2, and REL) and normalized to GAPDH. Data on hospital length of stay and modified Rankin score (MRS) were collected with 90-day MRS ≤ 3 as favorable o

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Lin, Minwa, Yingxue Zhong, Dan Zhou, et al. "Proximal tubule cells in blood and urine as potential biomarkers for kidney disease biopsy." PeerJ 11 (December 6, 2023): e16499. http://dx.doi.org/10.7717/peerj.16499.

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Early diagnosis and treatment are crucial for managing kidney disease, yet there remains a need to further explore pathological mechanisms and develop minimally invasive diagnostic methods. In this study, we employed single-cell RNA sequencing (scRNA-seq) to assess the cellular heterogeneity of kidney diseases. We analyzed gene expression profiles from renal tissue, peripheral blood mononuclear cells (PBMCs), and urine of four patients with nephritis. Our findings identified 12 distinct cell subsets in renal tissues and leukocytes. These subsets encompassed fibroblast cells, mesangial cells, e

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Chen, Tao, Li-xin Fu, Li-wen Zhang, et al. "Paeoniflorin suppresses inflammatory response in imiquimod-induced psoriasis-like mice and peripheral blood mononuclear cells (PBMCs) from psoriasis patients." Canadian Journal of Physiology and Pharmacology 94, no. 8 (2016): 888–94. http://dx.doi.org/10.1139/cjpp-2015-0483.

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Psoriasis is one of the most common immune-mediated chronic inflammatory skin disorders, characterized by hyperproliferation of keratinocytes, dilation and growth of dermal capillary vasculature, and cellular infiltration of T cells, dendritic cells (DCs), and neutrophils. Paeoniflorin (PF), the principal component of total glucosides of paeony (TGP), displays anti-inflammatory and antioxidant properties in several animal models. In this study, we investigated the anti-inflammatory effects and mechanisms of PF in imiquimod (IMQ)-induced psoriasis-like mouse model. The effects of PF on inflamma

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Wolters, Thalijn Liliana Catharina, Mihai Gheorghe Netea, Adrianus Rudolfus Marinus Maria Hermus, Johannes Willem Adriaan Smit, and Romana Teodora Netea-Maier. "IGF1 potentiates the pro-inflammatory response in human peripheral blood mononuclear cells via MAPK." Journal of Molecular Endocrinology 59, no. 2 (2017): 129–39. http://dx.doi.org/10.1530/jme-17-0062.

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Acromegaly is characterized by growth hormone (GH) and insulin-like growth factor 1 (IGF1) excess and is accompanied by an increased cardiovascular diseases (CVD) risk. As innate immune responses are crucial in CVD development, and IGF1 is linked to subclinical inflammation, we hypothesized that GH/IGF1 excess contributes to CVD development by potentiating systemic inflammation. We aimed to assess the effects of GH/IGF1 on inflammatory cytokine production. Whole blood from acromegaly patients and healthy volunteers and peripheral blood mononuclear cells (PBMCs) from healthy volunteers were sti

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Slusher, Aaron L., Yoshimi Shibata, Michael Whitehurst, Arun Maharaj, Justin M. Quiles, and Chun-Jung Huang. "Exercise reduced pentraxin 3 levels produced by endotoxin-stimulated human peripheral blood mononuclear cells in obese individuals." Experimental Biology and Medicine 242, no. 12 (2017): 1279–86. http://dx.doi.org/10.1177/1535370217706963.

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The purpose of this study was to determine whether obesity would reduce the capacity of peripheral blood mononuclear cells (PBMCs) to produce the anti-inflammatory protein pentraxin 3 (PTX3) in response to ex vivo stimulation with lipopolysaccharide (LPS), and if acute aerobic exercise would enhance this PTX3 production capacity. In addition, the inter-relationships of LPS-induced PTX3 with the inflammatory cytokines (interleukin 6 [IL-6], IL-10, and tumor necrosis factor alpha) were examined. Twenty-one healthy subjects (10 obese and 11 normal-weight) performed an acute bout of aerobic exerci

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Piotrowska, Katarzyna, Sylwia Słuczanowska-Głabowska, Mateusz Kurzawski, et al. "Over-Expression of Allograft Inflammatory Factor-1 (AIF-1) in Patients with Rheumatoid Arthritis." Biomolecules 10, no. 7 (2020): 1064. http://dx.doi.org/10.3390/biom10071064.

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Allograft inflammatory factor-1 (AIF-1) is a cytoplasmic protein that is encoded by the AIF1 gene. The main functions of AIF-1 are the activation of macrophages and enhancing the production of pro-inflammatory cytokines. To date, three different AIF-1 isoforms have been identified. In this study, we examined the expression of AIF-1 isoforms on the level of mRNA, and we compared the percentage of AIF-1-positive white blood cells (WBCs) in blood and AIF-1/CD68 cells in the synovial membranes in patients with rheumatoid arthritis (RA) and osteoarthritis (OA). We examined 15 patients with RA and 1

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Heim, Cortney E., Kelsey J. Yamada, Rachel Fallet, et al. "Orthopaedic Surgery Elicits a Systemic Anti-Inflammatory Signature." Journal of Clinical Medicine 9, no. 7 (2020): 2123. http://dx.doi.org/10.3390/jcm9072123.

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Little information is available on the functional activity of leukocytes after arthroplasty or the expansion of populations with immune suppressive properties during the acute post-operative period. Synovial fluid and matched pre- and post-surgical blood samples were collected from total hip and knee arthroplasty patients (THA and TKA, respectively) to examine the impact of surgery on peripheral blood leukocyte frequency, bactericidal activity, and inflammatory mediator expression. For spinal surgeries, inflammatory mediator production by peripheral blood mononuclear cells (PBMCs) pre- and pos

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Fakhoury, Hana M. A., Muhammad Affan Elahi, Saud Al Sarheed, et al. "Gene Expression Profiling of Peripheral Blood Mononuclear Cells in Type 2 Diabetes: An Exploratory Study." Medicina 58, no. 12 (2022): 1829. http://dx.doi.org/10.3390/medicina58121829.

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Background and Objectives: Visceral obesity is associated with chronic low-grade inflammation that predisposes to metabolic syndrome. Indeed, infiltration of adipose tissue with immune–inflammatory cells, including ‘classical’ inflammatory M1 and anti-inflammatory ‘alternative’ M2 macrophages, causes the release of a variety of bioactive molecules, resulting in the metabolic complications of obesity. This study examined the relative expression of macrophage phenotypic surface markers, cholesterol efflux proteins, scavenger receptors, and adenosine receptors in human circulating peripheral bloo

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Byrnes, Heather D., Heather Kaminski, Asra Mirza, Gregory Deno, Daniel Lundell та Jay S. Fine. "Macrophage Inflammatory Protein-3β Enhances IL-10 Production by Activated Human Peripheral Blood Monocytes and T Cells". Journal of Immunology 163, № 9 (1999): 4715–20. http://dx.doi.org/10.4049/jimmunol.163.9.4715.

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Abstract We report that the addition of human macrophage inflammatory protein-3β (MIP-3β) to cultures of human PBMCs that have been activated with LPS or PHA results in a significant enhancement of IL-10 production. This effect was concentration-dependent, with optimal MIP-3β concentrations inducing more than a 5-fold induction of IL-10 from LPS-stimulated PBMCs and a 2- to 3-fold induction of IL-10 from PHA-stimulated PBMCs. In contrast, no significant effect on IL-10 production was observed when 6Ckine, the other reported ligand for human CCR7, or other CC chemokines such as monocyte chemoat

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Fang, Lu, Xiao-Jun Du, Xiao-Ming Gao, and Anthony M. Dart. "Activation of peripheral blood mononuclear cells and extracellular matrix and inflammatory gene profile in acute myocardial infarction." Clinical Science 119, no. 4 (2010): 175–83. http://dx.doi.org/10.1042/cs20100011.

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Inflammation and ECM (extracellular matrix) remodelling play important roles in LV (left ventricular) remodelling following acute MI (myocardial infarction). Previous studies show elevated plasma MMP (matrix metalloproteinase) levels in patients with acute MI, but their sources are not clear. The recruitment of mononuclear cells into the infarcted myocardium is critical for inflammatory responses, but their exact roles in LV remodelling have not been fully investigated, as it is difficult to isolate and study the function of regional inflammatory cells. To address these questions, we isolated

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Jachiet, V., L. Ricard, P. Hirsch, et al. "AB0044 REDUCED PERIPHERAL BLOOD MYELOID CELLS IN PATIENTS WITH VEXAS SYNDROME." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1157.2–1157. http://dx.doi.org/10.1136/annrheumdis-2022-eular.5346.

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BackgroundSystemic inflammatory or dysimmune diseases (SIDDs) are encountered in up to a quarter of patients with myelodysplastic syndromes (MDS). Recently identified VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome, associated with somatic mutations in UBA1, encompasses a range of severe inflammatory conditions along with hematologic abnormalities, including myelodysplasia. Only limited data are available on the pathophysiology of MDS-associated SIDDs, and especially about the role of different myeloid cell subsets.ObjectivesThe aim of this study was to describe the p

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Volova, Larisa T., Natalya K. Osina, Sergei I. Kuznetsov, et al. "Donor-specific production of cytokines by blood cells under the influence of immunomodulators: New aspects of a personalized approach in medicine." Science and Innovations in Medicine 7, no. 4 (2022): 250–57. http://dx.doi.org/10.35693/2500-1388-2022-7-4-250-257.

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Aim to study the immunomodulator-induced individual cytokine production by peripheral blood mononuclear cells (PBMCs) and to evaluate the potential of using this approach as a universal cellular test system in personalized medicine. Material and methods. The peripheral blood mononuclear cells given by donors were cultured in vitro in the presence of immunomodulators Imunofan and Polyoxidonium. After incubation, the enzyme-linked immunosorbent assay (ELISA) of the culture medium for the presence of pro-inflammatory cytokines IL-6, IL-8/CXCL8, MCP-1/CCL2, and IFN- cytokines was performed.&

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Salmeri, Francesca Maria, Lucia Denaro, Elisa Ruello, et al. "Irradiation with Polychromatic Incoherent Low Energy Radiation of Human Peripheral Blood Mononuclear Cells In Vitro: Effects on Cytokine Production." International Journal of Environmental Research and Public Health 17, no. 4 (2020): 1233. http://dx.doi.org/10.3390/ijerph17041233.

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(1) Background: Physical stimuli may activate peripheral blood mononuclear cells (PBMCs) to secrete cytokines, which may favor pro-inflammatory responses or trigger reparative phenomena. The purpose of this study is to evaluate the action of Polarized Polychromatic Incoherent Low Energy Radiation (PILER) on human in vitro PBMCs, by detection of the possible effects on cytokine production; (2) Methods: isolated PBMCs were irradiated with a PILER lamp at different exposure times, at a distance of 10 cm, before incubation. The supernatants were collected after 24 h and 48 h and cytokines evaluate

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Bae, Seyeon, Jae Seung Kang, Hye Min Kim, et al. "CM1 Enhances Proinflammatory cytokine Production in Peripheral Blood Mononuclear Cells and Synovial Fluid Mononuclear Cells from Rheumatoid Arthritis Patients (99.53)." Journal of Immunology 182, no. 1_Supplement (2009): 99.53. http://dx.doi.org/10.4049/jimmunol.182.supp.99.53.

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Abstract CM1 (centrocyte/-blast marker 1) is expressed on the surface of activated peripheral blood mononuclear cells (PBMCs). Recently, we found that the production of prostaglandin E2 (PGE2) from activated PBMCs was increased by CM1 stimulation via the activation of nuclear factor kappa B (NF-kB). Therefore, this study was attempted to investigate the roles of CM1 in the regulation of rheumatoid arthritis (RA). PBMCs were purified from healthy donors, RA patients and degenerative osteoarthritis (OA) patients, and knee joint synovial fluid mononuclear cells (SFMCs) were purified from RA patie

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Gugliandolo, Enrico, Rosalia Crupi, Vito Biondi, Patrizia Licata, Salvatore Cuzzocrea, and Annamaria Passantino. "Protective Effect of Silibinin on Lipopolysaccharide-Induced Inflammatory Responses in Equine Peripheral Blood Mononuclear Cells, an In Vitro Study." Animals 10, no. 11 (2020): 2022. http://dx.doi.org/10.3390/ani10112022.

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Although inflammation is an important physiological response, it plays a prominent role in several diseases across the mammalian species. In horses, in particular, inflammation secondary to bacterial infection or translocation is one of the most frequent causes of morbidity and mortality. Research in new molecules with anti-inflammatory and immunomodulatory proprieties and safe use profile is constantly an active field; natural compounds are an important source of molecules with peculiar properties such as antioxidants, anti-inflammatory and immune modulating. Silibinin, a natural polyphenolic

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Xuan, Nguyen Thi, and Nguyen Huy Hoang. "The regulatory role of peripheral blood mononuclear cell function by A20." Vietnam Journal of Biotechnology 17, no. 4 (2020): 603–9. http://dx.doi.org/10.15625/1811-4989/17/4/14482.

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Peripheral blood mononuclear cells (PBMC) consist of lymphocytes (T cells, B cells, natural killer cells), monocytes and dendritic cells and play important roles in initiating and regulating immunity against pathogens or immunotolerance to allergens. Activation of PBMCs is induced upon exposure to multiple stimuli by the binding with toll-like receptors (TLRs), recognition elements of the innate immune system. A20 is a negative regulator of nuclear factor (NF)-κB-dependent immune reaction in response to TLR ligands. A20-deficient mice display severe inflammation, tissue damage in multiple orga

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Wang, Lifang, Yu Zhang, Mingqin Zhu, et al. "Effects of Follicular Helper T Cells and Inflammatory Cytokines on Myasthenia Gravis." Current Molecular Medicine 19, no. 10 (2019): 739–45. http://dx.doi.org/10.2174/1566524019666190827162615.

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Background: Myasthenia gravis (MG) is an autoimmune disorder mediated by antibodies against the acetylcholine receptors (AChR) of the skeletal muscles. An imbalance in various T helper (Th) cells, including Th1, Th2, Th17, Th22 and follicular helper T (TFH) cells, has been found associated with immunological disturbances. Objective: In this study, we aim to investigate the role of the Th cells in peripheral blood of MG patients. Materials and Methods: A total of 33 MG patients and 34 age matched controls were enrolled in this study. Peripheral blood mononuclear cells (PBMCs) were isolated usin

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Negera, Edessa, Kidist Bobosha, Abraham Aseffa, Hazel M. Dockrell, Diana N. J. Lockwood, and Stephen L. Walker. "Regulatory T cells in erythema nodosum leprosum maintain anti-inflammatory function." PLOS Neglected Tropical Diseases 16, no. 7 (2022): e0010641. http://dx.doi.org/10.1371/journal.pntd.0010641.

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Background The numbers of circulating regulatory T cells (Tregs) are increased in lepromatous leprosy (LL) but reduced in erythema nodosum leprosum (ENL), the inflammatory complication of LL. It is unclear whether the suppressive function of Tregs is intact in both these conditions. Methods A longitudinal study recruited participants at ALERT Hospital, Ethiopia. Peripheral blood samples were obtained before and after 24 weeks of prednisolone treatment for ENL and multidrug therapy (MDT) for participants with LL. We evaluated the suppressive function of Tregs in the peripheral blood mononuclear

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Baba, Tomohisa, Akihiro Ishizu, Sari Iwasaki, et al. "CD4+/CD8+ macrophages infiltrating at inflammatory sites: a population of monocytes/macrophages with a cytotoxic phenotype." Blood 107, no. 5 (2006): 2004–12. http://dx.doi.org/10.1182/blood-2005-06-2345.

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We found a population of nonlymphoid cells expressing both CD4 and CD8 in peripheral blood mononuclear cells (PBMCs) of human T-cell leukemia virus type-I pX transgenic rats with autoimmune diseases. These cells, which showed a monocytic phenotype, were also found in wild-type rats, and their number increased by adjuvant-assisted immunization. GM-CSF increased the number of these double-positive (DP) monocytes in PBMCs. Consistent with the idea that DP monocytes differentiate into DP macrophages at sites of inflammation, we found infiltration of DP macrophages at the site of myosin-induced myo

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Lv, Jingzhu, Xiaojie Zhang, Caizhi Wang, Hongtao Wang, Ting Wang, and Zhongqing Qian. "Hydrogen peroxide promotes the activation of preeclampsia peripheral T cells." Innate Immunity 24, no. 4 (2018): 203–9. http://dx.doi.org/10.1177/1753425918767305.

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Preeclampsia (PE) is a pregnancy disorder with a high mortality rate. Patients with PE exhibit systemic high oxidative stress status and inflammatory immune activation. This study aims to define the role of H2O2 in the activation of neutrophils and T lymphocytes in PE patients. CD3+/HLA-DR+ cells in blood from PE patients are remarkably increased compared with those of normal non-pregnancies or normal pregnancies, while the percentage of CD3+/CD62L+ cells is significantly reduced in PE patients compared to normal pregnancies. Furthermore, CD62L levels in granulocytes of periphery blood of PE p

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Aguilar Briseño, José Alberto, Lennon Ramos Pereira, Marleen van der Laan, et al. "TLR2 axis on peripheral blood mononuclear cells regulates inflammatory responses to non-infectious immature dengue virus particles." PLOS Pathogens 18, no. 10 (2022): e1010499. http://dx.doi.org/10.1371/journal.ppat.1010499.

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Severe dengue virus (DENV) infection is characterized by exacerbated inflammatory responses that lead to endothelial dysfunction and plasma leakage. We have recently demonstrated that Toll-like receptor 2 (TLR2) on blood monocytes senses DENV infection leading to endothelial activation. Here, we report that non-infectious immature DENV particles, which are released in large numbers by DENV-infected cells, drive endothelial activation via the TLR2 axis. We show that fully immature DENV particles induce a rapid, within 6 hours post-infection, inflammatory response in PBMCs. Furthermore, pharmaco

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David, Bwanbale Geoffrey. "The Role of Medicinal Plants in Mitigating HIV-Related Inflammation." IDOSR JOURNAL OF BIOCHEMISTRY, BIOTECHNOLOGY AND ALLIED FIELDS 10, no. 1 (2025): 1–7. https://doi.org/10.59298/idosr/jbbaf/2025/10117.

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Despite the transformative role of antiretroviral therapy (ART) in managing HIV, chronic inflammation persists in people living with HIV (PLWH), contributing to immune exhaustion and the development of non-AIDS comorbidities. Persistent immune activation marked by elevated pro-inflammatory cytokines and T-cell exhaustion markers such as PD-1 and CD69—continues to drive pathogenesis, even in individuals with suppressed viral loads. Medicinal plants, long used in traditional health systems, offer bioactive compounds with significant immunomodulatory and anti-inflammatory potential. This paper in

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Li, Cheng-Yan, Yueh-Tung Chen, Tossapol Moonmanee, Jacky Peng-Wen Chan, and Chien-Kai Wang. "The In Vitro Effects of Choline on Non-Esterified Fatty Acid-Treated Bovine Peripheral Blood Leukocytes." Animals 15, no. 12 (2025): 1814. https://doi.org/10.3390/ani15121814.

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The transition period is defined as 3 weeks around parturition, involving the rapid increase in the energy demand, promoting adipose mobilization and non-esterified fatty acid (NEFA) release. High NEFA levels might cause oxidative stress and associated health risks, including the disruption of the immune capability of peripheral leukocytes. Nutrient supplementation of choline, which improves cellular lipid metabolism and controls lipid oxidation, potentially maintains the integrity of peripheral leukocytes and alleviates the impacts of increased NEFAs. This study investigated the effects of ch

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Muñoz, Alexandra, and Max Costa. "Nutritionally Mediated Oxidative Stress and Inflammation." Oxidative Medicine and Cellular Longevity 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/610950.

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There are many sources of nutritionally mediated oxidative stress that trigger inflammatory cascades along short and long time frames. These events are primarily mediated via NFκB. On the short-term scale postprandial inflammation is characterized by an increase in circulating levels of IL-6 and TNF-αand is mirrored on the long-term by proinflammatory gene expression changes in the adipocytes and peripheral blood mononuclear cells (PBMCs) of obese individuals. Specifically the upregulation ofCCL2/MCP-1,CCL3/MIP-1α,CCL4/MIP-1β,CXCL2/MIP-2α, andCXCL3/MIP-2βis noted because these changes have bee

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Morita, Taku, Keiichi Mitsuyama, Hiroshi Yamasaki, et al. "Gene Expression of Transient Receptor Potential Channels in Peripheral Blood Mononuclear Cells of Inflammatory Bowel Disease Patients." Journal of Clinical Medicine 9, no. 8 (2020): 2643. http://dx.doi.org/10.3390/jcm9082643.

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We examined the expression profile of transient receptor potential (TRP) channels in peripheral blood mononuclear cells (PBMCs) from patients with inflammatory bowel disease (IBD). PBMCs were obtained from 41 ulcerative colitis (UC) patients, 34 Crohn’s disease (CD) patients, and 30 normal subjects. mRNA levels of TRP channels were measured using the quantitative real-time polymerase chain reaction, and correlation tests with disease ranking, as well as laboratory parameters, were performed. Compared with controls, TRPV2 and TRPC1 mRNA expression was lower, while that of TRPM2, was higher in P

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Tang, Chun, Xiaohua Wang, Yingying Xie, et al. "4-Octyl Itaconate Activates Nrf2 Signaling to Inhibit Pro-Inflammatory Cytokine Production in Peripheral Blood Mononuclear Cells of Systemic Lupus Erythematosus Patients." Cellular Physiology and Biochemistry 51, no. 2 (2018): 979–90. http://dx.doi.org/10.1159/000495400.

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Background/Aims: Increased production of multiple pro-inflammatory cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, plays an essential pathogenic role in the progression of systemic lupus erythematosus (SLE). Recent studies have characterized itaconate as a novel and potent nuclear-factor-E2-related factor 2 (Nrf2) activator that activates Nrf2 signaling by alkylating cysteine residues on Keap1 (Kelch-like ECH-associated protein 1). Methods: THP-1 human macrophages and peripheral blood mononuclear cells (PBMCs) of SLE patients were treated with 4-octyl itacona

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Zhou, Gengxu, Xiaoyang Hong, Yuhang Liu, and Zhichun Feng. "Effect of Cardiopulmonary Bypass on Annexin A1 Expression in Peripheral Blood Mononuclear Cells of Children with Congenital Heart Disease." Journal of Medical Biochemistry 31, no. 3 (2012): 193–98. http://dx.doi.org/10.2478/v10011-011-0054-y.

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Effect of Cardiopulmonary Bypass on Annexin A1 Expression in Peripheral Blood Mononuclear Cells of Children with Congenital Heart DiseaseThis study aimed to investigate the effect of cardiopulmonary bypass (CPB) on Annexin A1 expression in the peripheral blood mononuclear cells (PBMCs) of children with congenital heart disease (CHD). A total of 30 children receiving CPB for interventricular septal defect were included. Peripheral blood was collected before and after CPB. PBMCs were collected by density gradient centrifugation. Protein extraction was performed by lysis and subjected to 2D-QUANT

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Yellowhair, Tracylyn R., Shahani Noor, Brittney Mares, et al. "Chorioamnionitis in Rats Precipitates Extended Postnatal Inflammatory Lymphocyte Hyperreactivity." Developmental Neuroscience 40, no. 5-6 (2018): 523–33. http://dx.doi.org/10.1159/000497273.

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Preterm birth is an important cause of perinatal brain injury (PBI). Neurological injury in extremely preterm infants often begins in utero with chorioamnionitis (CHORIO) or inflammation/infection of the placenta and concomitant placental insufficiency. Studies in humans have shown dysregulated inflammatory signaling throughout the placental-fetal brain axis and altered peripheral immune responses in children born preterm with cerebral palsy (CP). We hypothesized that peripheral immune responses would be altered in our well-established rat model of CP. Specifically, we proposed that isolated p

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Kodama, M., HK Takahashi, H. Iwagaki, et al. "Effect of Steroids on Lipopolysaccharide/Interleukin 2-Induced Interleukin 18 Production in Peripheral Blood Mononuclear Cells." Journal of International Medical Research 30, no. 2 (2002): 144–60. http://dx.doi.org/10.1177/147323000203000207.

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Interleukin (IL) 18, a powerful inducer of the immunoregulatory cytokine interferon-γ (IFN-γ), presents upstream of the cytokine activation cascade in the inflammatory response. The anti-inflammatory properties of steroids permit their use in various conditions, although effects are transient and pathological states are not fully relieved by short-term steroidal use. We examined the effect of lipopolysaccharide (LPS)/IL-2 on the cytokine cascade in human peripheral blood mononuclear cells (PBMCs). We also examined the effect of steroids on LPS/IL-2-induced cytokine production in human PBMCs ta

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Enayati, Samaneh, Mozhgan Moharamoghli, Ali Farazmand, et al. "Upregulated Gene Expression of Histone Deacetylases (HDAC) 1, 2, and 11 in Peripheral Blood Mononuclear Cells of Rheumatoid Arthritis Patients." Journal of Cellular Immunology 6, no. 4 (2024): 188–95. http://dx.doi.org/10.33696/immunology.6.205.

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Background: The histone deacetylase (HDAC) family consists of epigenetic modifiers that demonstrate anti-inflammatory activities, and hence they might have a substantial role in auto-inflammatory disorders including rheumatoid arthritis (RA). Therefore, the aim of this study is to investigate the expression of HDAC1, HDAC2, and HDAC11 genes in peripheral blood mononuclear cells (PBMCs) of RA cases compared to healthy controls. Methods: In the current study, PBMCs were isolated after blood collection from 50 RA patients and 50 healthy controls. Afterward, RNA extraction and cDNA synthesis was p

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Lee, Kuo-Hua, Kai-Chen Hsu, Yu-Shan Wang, et al. "EFFECTS OF TARAXACUM MONGOLICUM EXTRACT ON LIPOPOLYSACCHARIDE-INDUCED NITRIC OXIDE AND CYTOKINES PRODUCTION BY BOVINE PERIPHERAL BLOOD MONONUCLEAR CELLS." Taiwan Veterinary Journal 42, no. 04 (2016): 203–12. http://dx.doi.org/10.1142/s1682648515500304.

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The objective of this study is to investigate Taraxacum mongolicum (TM) as a therapeutic alternative for preventing and treating bovine mastitis. The effect of the anti-inflammatory activity of Taraxacum mongolicum extract (TME) on lipopolysaccharide (LPS)-induced responses was studied in the bovine peripheral blood mononuclear cells (PBMCs). The dried plant TM was extracted with 10 volumes of distilled water to generate its water extract. PBMCs were pretreated with various concentrations of TME (0, 1, 10, 100, 1000 [Formula: see text]g/mL) and subsequently incubated with LPS (1 [Formula: see

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Biswas, Priscilla, Fanny Delfanti, Sergio Bernasconi, et al. "Interleukin-6 Induces Monocyte Chemotactic Protein-1 in Peripheral Blood Mononuclear Cells and in the U937 Cell Line." Blood 91, no. 1 (1998): 258–65. http://dx.doi.org/10.1182/blood.v91.1.258.

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Abstract Induction of chemokine gene expression from peripheral blood mononuclear cells (PBMCs) stimulated by proinflammatory cytokines plays an important role in both wound repair and response to infectious agents. In the present study, we show that the proinflammatory cytokine interleukin-6 (IL-6) potently induced mRNA expression and secretion of the CC chemokine monocyte chemotactic protein 1 (MCP-1) in PBMCs. In addition, because human immunodeficiency virus (HIV) infection in vivo and in vitro has been shown to dysregulate the production of and/or the response to cytokines, PBMCs from bot

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Biswas, Priscilla, Fanny Delfanti, Sergio Bernasconi, et al. "Interleukin-6 Induces Monocyte Chemotactic Protein-1 in Peripheral Blood Mononuclear Cells and in the U937 Cell Line." Blood 91, no. 1 (1998): 258–65. http://dx.doi.org/10.1182/blood.v91.1.258.258_258_265.

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Induction of chemokine gene expression from peripheral blood mononuclear cells (PBMCs) stimulated by proinflammatory cytokines plays an important role in both wound repair and response to infectious agents. In the present study, we show that the proinflammatory cytokine interleukin-6 (IL-6) potently induced mRNA expression and secretion of the CC chemokine monocyte chemotactic protein 1 (MCP-1) in PBMCs. In addition, because human immunodeficiency virus (HIV) infection in vivo and in vitro has been shown to dysregulate the production of and/or the response to cytokines, PBMCs from both healthy

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Kiyohara, H., T. Toyonaga, S. Kuronuma, et al. "P035 NUDT15 variance increases DNA-incorporated thiopurine metabolites and lymphocyte apoptosis in patients with inflammatory bowel disease." Journal of Crohn's and Colitis 14, Supplement_1 (2020): S149—S150. http://dx.doi.org/10.1093/ecco-jcc/jjz203.164.

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Abstract Background A novel thiopurine metabolizing enzyme, nucleotide diphosphate-linked moiety X-type motif 15 (NUDT15) was associated with drug-induced leukopenia in patients with non-synonymous genetic polymorphisms. Thiopurine-induced leukopenia in Japanese patients with genetic variance in NUDT15 (c.415C&gt;T) appears to be independent of the 6-thioguanine nucleotide concentration in red blood cells. However, detailed molecular mechanism how NUDT15 variance causes thiopurine-induced leukopenia remains unclear and NUDT15-associated subcellular thiopurine metabolism has not been invest

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Aldossari, Abdullah A., Mushtaq A. Ansari, Ahmed Nadeem, et al. "Upregulation of Inflammatory Mediators in Peripheral Blood CD40+ Cells in Children with Autism Spectrum Disorder." International Journal of Molecular Sciences 24, no. 8 (2023): 7475. http://dx.doi.org/10.3390/ijms24087475.

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Autism spectrum disorder (ASD) is a common and severe neurodevelopmental disorder in early childhood, defined as social and communication deficits and repetitive and stereotypic behaviours. The aetiology is unknown in most cases. However, several studies have identified immune dysregulation as potentially promoting ASD. Among the numerous immunological findings in ASD, reports of increased pro-inflammatory markers remain the most consistently observed. C-C chemokine receptor type 1 (CCR1) activation is pro-inflammatory in several neurological disorders. Previous evidence has implied that the e

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Panahipour, Layla, Zahra Kargarpour, Maria Laggner, Michael Mildner, Hendrik J. Ankersmit та Reinhard Gruber. "TGF-β in the Secretome of Irradiated Peripheral Blood Mononuclear Cells Supports In Vitro Osteoclastogenesis". International Journal of Molecular Sciences 21, № 22 (2020): 8569. http://dx.doi.org/10.3390/ijms21228569.

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Osteoclastogenesis required for bone remodeling is also a key pathologic mechanism of inflammatory osteolysis being controlled by paracrine factors released from dying cells. The secretome of irradiated, dying peripheral blood mononuclear cells (PBMCs) has a major impact on the differentiation of myeloid cells into dendritic cells, and macrophage polarization. The impact on osteoclastogenesis, however, has not been reported. For this aim, we used murine bone marrow macrophages exposed to RANKL and M-CSF to initiate osteoclastogenesis, with and without the secretome obtained from γ-irradiated P

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Espeland, Kristian, Andrius Kleinauskas, Petras Juzenas, et al. "Photodynamic Effects with 5-Aminolevulinic Acid on Cytokines and Exosomes in Human Peripheral Blood Mononuclear Cells." Biomedicines 10, no. 2 (2022): 232. http://dx.doi.org/10.3390/biomedicines10020232.

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Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA), a precursor to the potent photosensitizer, protoporphyrin IX (PpIX), is an established modality for several malignant and premalignant diseases. This treatment is based on the light-activated PpIX in targeted lesions. Although numerous studies have confirmed the necrosis and apoptosis involved in the mechanism of action of this modality, little information is available for the change of exosome levels after treatment. We report from the first study on the effects of ALA-PDT on cytokines and exosomes of human healthy peripheral blood

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Yin, Xuejiao, Yi Liu, Shengnan Ding та ін. "IFN-γ promotes the progression of iMCD by activating inflammatory monocytes". Blood Journal, 31 березня 2025. https://doi.org/10.1182/blood.2024027689.

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A deeper understanding of the immune landscape in patients with idiopathic multicentric Castleman disease (iMCD) is essential to establish early prognostic stratification and uncover novel therapeutic targets. We employed single-cell RNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) from a cohort of 15 patients with iMCD and four healthy controls. To explore the sources of interleukin-6 (IL-6), we included lymph node and bone marrow samples for comparison with PBMCs. Our results indicate that IL-6 primarily originates from the lymph nodes, particularly from activated B c

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Jeenkeawpieam, Juthatip, Chananphat Tantikositruj, Warangkana Kitpipit, et al. "Expression of toll-like receptor 4 and its associated cytokines from peripheral blood mononuclear cells in Leghorn chickens." Veterinary World, July 2023, 1541–45. http://dx.doi.org/10.14202/vetworld.2023.1541-1545.

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Background and Aim: Immune cells require toll-like receptor 4 (TLR4) to respond to lipopolysaccharides (LPS) by releasing pro-inflammatory cytokines. Peripheral blood mononuclear cells (PBMCs) are used to assess changes in cytokines released in response to diseases or pathogens. This study aimed to assess TLR4 gene expression in PBMCs from Leghorn chicken and the release of related cytokines. Materials and Methods: Peripheral blood mononuclear cells were isolated from blood samples obtained from Leghorn chicks. The PBMC cultures were stimulated with various concentrations of LPS (0.01-1 µg/ml)

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