Log in

Relevant bibliographies by topics / Peripheral channel / Journal articles

To see the other types of publications on this topic, follow the link: Peripheral channel.

Journal articles on the topic 'Peripheral channel'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Peripheral channel.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Bezes, Christophe. "Identifying Central And Peripheral Dimensions Of Store And Website Image: Applying The Elaboration Likelihood Model To Multichannel Retailing." Journal of Applied Business Research (JABR) 31, no. 4 (2015): 1453. http://dx.doi.org/10.19030/jabr.v31i4.9362.

Full text

Abstract:

Could the difficulties that retailers face in creating a seamless, cross-channel experience be due to the fact that their stores and website activate such different central and peripheral routes to persuasion that perfect transferability between channels is not possible? By relying on a rigorous and innovative dual-step methodology, this study provides a solid support for research aimed at identifying other channel-related central and peripheral elements. Although perceptual structure of the two channels is very similar, the store and website have no central or peripheral dimension in common.

APA, Harvard, Vancouver, ISO, and other styles

2

Ivasiuk, Arsentii, Maksym Matvieienko, Nikolai I. Kononenko, et al. "Diabetes-Induced Amplification of Nociceptive DRG Neuron Output by Upregulation of Somatic T-Type Ca2+ Channels." Biomolecules 13, no. 9 (2023): 1320. http://dx.doi.org/10.3390/biom13091320.

Full text

Abstract:

The development of pain symptoms in peripheral diabetic neuropathy (PDN) is associated with the upregulation of T-type Ca2+ channels (T-channels) in the soma of nociceptive DRG neurons. Moreover, a block of these channels in DRG neurons effectively reversed mechanical and thermal hyperalgesia in animal diabetic models, indicating that T-channel functioning in these neurons is causally linked to PDN. However, no particular mechanisms relating the upregulation of T-channels in the soma of nociceptive DRG neurons to the pathological pain processing in PDN have been suggested. Here we have electro

APA, Harvard, Vancouver, ISO, and other styles

3

Ślęczkowska, Milena, Kaalindi Misra, Silvia Santoro, Monique M. Gerrits, and Janneke G. J. Hoeijmakers. "Ion Channel Genes in Painful Neuropathies." Biomedicines 11, no. 10 (2023): 2680. http://dx.doi.org/10.3390/biomedicines11102680.

Full text

Abstract:

Neuropathic pain (NP) is a typical symptom of peripheral nerve disorders, including painful neuropathy. The biological mechanisms that control ion channels are important for many cell activities and are also therapeutic targets. Disruption of the cellular mechanisms that govern ion channel activity can contribute to pain pathophysiology. The voltage-gated sodium channel (VGSC) is the most researched ion channel in terms of NP; however, VGSC impairment is detected in only <20% of painful neuropathy patients. Here, we discuss the potential role of the other peripheral ion channels involved in

APA, Harvard, Vancouver, ISO, and other styles

4

Bräu, Michael E., E. Dietlind Koch, Werner Vogel, and Gunter Hempelmann. "Tonic Blocking Action of Meperidine on Na+and K+Channels in Amphibian Peripheral Nerves." Anesthesiology 92, no. 1 (2000): 147. http://dx.doi.org/10.1097/00000542-200001000-00026.

Full text

Abstract:

Background Among opioids, meperidine (pethidine) also shows local anesthetic activity when applied locally to peripheral nerve fibers and has been used for this effect in the clinical setting for regional anesthesia. This study investigated the blocking effects of meperidine on different ion channels in peripheral nerves. Methods Experiments were conducted using the outside-out configuration of the patch-clamp method applied to enzymatically prepared peripheral nerve fibers of Xenopus laevis. Half-maximal inhibiting concentrations were determined for Na+ channels and different K+ channels by n

APA, Harvard, Vancouver, ISO, and other styles

5

Rodríguez-Rivera, Nidia Samara, and Diana Barrera-Oviedo. "Exploring the Pathophysiology of ATP-Dependent Potassium Channels in Insulin Resistance." International Journal of Molecular Sciences 25, no. 7 (2024): 4079. http://dx.doi.org/10.3390/ijms25074079.

Full text

Abstract:

Ionic channels are present in eucaryotic plasma and intracellular membranes. They coordinate and control several functions. Potassium channels belong to the most diverse family of ionic channels that includes ATP-dependent potassium (KATP) channels in the potassium rectifier channel subfamily. These channels were initially described in heart muscle and then in other tissues such as pancreatic, skeletal muscle, brain, and vascular and non-vascular smooth muscle tissues. In pancreatic beta cells, KATP channels are primarily responsible for maintaining the membrane potential and for depolarizatio

APA, Harvard, Vancouver, ISO, and other styles

6

Brau, Michael E., Frank Sander, Werner Vogel, and Gunter Hempelmann. "Blocking Mechanisms of Ketamine and Its Enantiomers in Enzymatically Demyelinated Peripheral Nerve as Revealed by Single-channel Experiments." Anesthesiology 86, no. 2 (1997): 394–404. http://dx.doi.org/10.1097/00000542-199702000-00014.

Full text

Abstract:

Background Ketamine shows, besides its general anesthetic effect, a local anesthetic-like action that is due to blocking of peripheral nerve sodium currents. In this study, the stereoselectivity of the blocking effects of the ketamine enantiomers S(+) and R(-) was investigated in sodium and potassium channels in peripheral nerve membranes. Methods Ion channel blockade of ketamine was investigated in enzymatically dissociated Xenopus sciatic nerves in multiple-channel and in single-channel outside-out patches. Results Concentration-effect curves for the Na+ peak current revealed half-maximal in

APA, Harvard, Vancouver, ISO, and other styles

7

Kumamoto, Eiichi. "Anesthetic- and Analgesic-Related Drugs Modulating Both Voltage-Gated Na+ and TRP Channels." Biomolecules 14, no. 12 (2024): 1619. https://doi.org/10.3390/biom14121619.

Full text

Abstract:

Nociceptive information is transmitted by action potentials (APs) through primary afferent neurons from the periphery to the central nervous system. Voltage-gated Na+ channels are involved in this AP production, while transient receptor potential (TRP) channels, which are non-selective cation channels, are involved in receiving and transmitting nociceptive stimuli in the peripheral and central terminals of the primary afferent neurons. Peripheral terminal TRP vanilloid-1 (TRPV1), ankylin-1 (TRPA1) and melastatin-8 (TRPM8) activation produces APs, while central terminal TRP activation enhances

APA, Harvard, Vancouver, ISO, and other styles

8

MURRAY, I. J., N. R. A. PARRY, and D. J. McKEEFRY. "Cone opponency in the near peripheral retina." Visual Neuroscience 23, no. 3-4 (2006): 503–7. http://dx.doi.org/10.1017/s0952523806233315.

Full text

Abstract:

Changes of color perception in the peripheral field are measured using an asymmetric simultaneous matching paradigm. The data confirm previous observations in that saturation changes can be neutralized if the test target is increased in size. However, this compensation does not apply to hue shifts. We show that some hues remain unchanged with eccentricity whereas others exhibit substantial changes. Here the color shifts are plotted in terms of a second-stage cone opponent model. The data suggest that the S-L+M channel is more robust to increasing eccentricity than the L-M channel. Observations

APA, Harvard, Vancouver, ISO, and other styles

9

Khasanov, Timur A., Ekaterina E. Maleeva, Sergey G. Koshelev, et al. "Mutagenesis of the Peptide Inhibitor of ASIC3 Channel Introduces Binding to Thumb Domain of ASIC1a but Reduces Analgesic Activity." Marine Drugs 22, no. 9 (2024): 382. http://dx.doi.org/10.3390/md22090382.

Full text

Abstract:

Acid-sensing ion channels (ASICs), which act as proton-gating sodium channels, have garnered attention as pharmacological targets. ASIC1a isoform, notably prevalent in the central nervous system, plays an important role in synaptic plasticity, anxiety, neurodegeneration, etc. In the peripheral nervous system, ASIC1a shares prominence with ASIC3, the latter well established for its involvement in pain signaling, mechanical sensitivity, and inflammatory hyperalgesia. However, the precise contributions of ASIC1a in peripheral functions necessitate thorough investigation. To dissect the specific r

APA, Harvard, Vancouver, ISO, and other styles

10

Black, J. A., T. R. Cummins, C. Plumpton, et al. "Upregulation of a Silent Sodium Channel After Peripheral, but not Central, Nerve Injury in DRG Neurons." Journal of Neurophysiology 82, no. 5 (1999): 2776–85. http://dx.doi.org/10.1152/jn.1999.82.5.2776.

Full text

Abstract:

After transection of their axons within the sciatic nerve, DRG neurons become hyperexcitable. Recent studies have demonstrated the emergence of a rapidly repriming tetrodotoxin (TTX)-sensitive sodium current that may account for this hyperexcitability in axotomized small (<27 μm diam) DRG neurons, but its molecular basis has remained unexplained. It has been shown previously that sciatic nerve transection leads to an upregulation of sodium channel III transcripts, which normally are present at very low levels in DRG neurons, in adult rats. We show here that TTX-sensitive currents in small D

APA, Harvard, Vancouver, ISO, and other styles

11

Nau, Carla, Werner Vogel, Gunter Hempelmann, and Michael E. Bräu. "Stereoselectivity of Bupivacaine in Local Anesthetic–sensitive Ion Channels of Peripheral Nerve." Anesthesiology 91, no. 3 (1999): 786. http://dx.doi.org/10.1097/00000542-199909000-00031.

Full text

Abstract:

Background The local anesthetic bupivacaine exists in two stereoisomeric forms, R(+)- and S(-)-bupivacaine. Because of its lower cardiac and central nervous system toxicity, attempts were made recently to introduce S(-)-bupivacaine into clinical anesthesia. We investigated stereoselective actions of R(+)-and S(-)-bupivacaine toward two local anesthetic-sensitive ion channels in peripheral nerve, the Na+ and the flicker K+ channel. Methods In patch-clamp experiments on enzymatically demyelinated peripheral amphibian nerve fibers, Na+ and flicker K+ channels were investigated in outside-out patc

APA, Harvard, Vancouver, ISO, and other styles

12

Ishida, Y., and T. M. Chused. "Lack of voltage sensitive potassium channels and generation of membrane potential by sodium potassium ATPase in murine T lymphocytes." Journal of Immunology 151, no. 2 (1993): 610–20. http://dx.doi.org/10.4049/jimmunol.151.2.610.

Full text

Abstract:

Abstract Voltage sensitive K+ channels, which are responsible for generation of membrane potential in most cells, are functionally absent in about one-third of peripheral murine T cells and greatly reduced in the rest as shown by resistance of their membrane potential to changes in extracellular potassium concentration and failure of K+ channel dependent volume regulation. Despite the absence of voltage- sensitive K+ channels, the membrane potential of peripheral T cells is between -60 and -70 mV, the same as thymocytes. A total of 40 to 70 mV of the membrane potential of peripheral T cells is

APA, Harvard, Vancouver, ISO, and other styles

13

Cobo, Ramón, Jorge García-Piqueras, Yolanda García-Mesa, Jorge Feito, Olivia García-Suárez, and Jose A. Vega. "Peripheral Mechanobiology of Touch—Studies on Vertebrate Cutaneous Sensory Corpuscles." International Journal of Molecular Sciences 21, no. 17 (2020): 6221. http://dx.doi.org/10.3390/ijms21176221.

Full text

Abstract:

The vertebrate skin contains sensory corpuscles that are receptors for different qualities of mechanosensitivity like light brush, touch, pressure, stretch or vibration. These specialized sensory organs are linked anatomically and functionally to mechanosensory neurons, which function as low-threshold mechanoreceptors connected to peripheral skin through Aβ nerve fibers. Furthermore, low-threshold mechanoreceptors associated with Aδ and C nerve fibers have been identified in hairy skin. The process of mechanotransduction requires the conversion of a mechanical stimulus into electrical signals

APA, Harvard, Vancouver, ISO, and other styles

14

Bole, Velimir, Miha Dominko, Ada Gustin-Habus, and Janez Prasnikar. "Countries of former yugoslavia: Periphery vs. super-periphery in the great recession and beyond." Ekonomski anali 64, no. 223 (2019): 11–38. http://dx.doi.org/10.2298/eka1923011b.

Full text

Abstract:

The paper deals with the performance of former Yugoslav countries during the Great Recession. It compares the performance of peripheral countries (Slovenia and Croatia) with those of superperipheral countries (Bosnia, the Republic of North Macedonia, Montenegro, and Serbia). The focus of the analysis is the four channels of crisis transmission and amplification: the capital surge as the external channel on the one hand, and the financial accelerator, the banking credit extension, and liquidity as internal channels on the other. While the external channel drove the dynamics of the crisis, the i

APA, Harvard, Vancouver, ISO, and other styles

15

Zhou, Zijing, and Boris Martinac. "Mechanisms of PIEZO Channel Inactivation." International Journal of Molecular Sciences 24, no. 18 (2023): 14113. http://dx.doi.org/10.3390/ijms241814113.

Full text

Abstract:

PIEZO channels PIEZO1 and PIEZO2 are the newly identified mechanosensitive, non-selective cation channels permeable to Ca2+. In higher vertebrates, PIEZO1 is expressed ubiquitously in most tissues and cells while PIEZO2 is expressed more specifically in the peripheral sensory neurons. PIEZO channels contribute to a wide range of biological behaviors and developmental processes, therefore driving significant attention in the effort to understand their molecular properties. One prominent property of PIEZO channels is their rapid inactivation, which manifests itself as a decrease in channel open

APA, Harvard, Vancouver, ISO, and other styles

16

Aleixandre-Carrera, Fernando, Nurit Engelmayer, David Ares-Suárez, et al. "Optical Assessment of Nociceptive TRP Channel Function at the Peripheral Nerve Terminal." International Journal of Molecular Sciences 22, no. 2 (2021): 481. http://dx.doi.org/10.3390/ijms22020481.

Full text

Abstract:

Free nerve endings are key structures in sensory transduction of noxious stimuli. In spite of this, little is known about their functional organization. Transient receptor potential (TRP) channels have emerged as key molecular identities in the sensory transduction of pain-producing stimuli, yet the vast majority of our knowledge about sensory TRP channel function is limited to data obtained from in vitro models which do not necessarily reflect physiological conditions. In recent years, the development of novel optical methods such as genetically encoded calcium indicators and photo-modulation

APA, Harvard, Vancouver, ISO, and other styles

17

Patyra, Andrzej, and Grzegorz Witkowski. "VOLTAGE-GATED SODIUM CHANNELS MUTATIONS AND THEIR ROLE IN EPILEPSY." Prospects in Pharmaceutical Sciences 20, no. 1 (2022): 11–18. http://dx.doi.org/10.56782/pps.1.

Full text

Abstract:

Voltage-gated ion channels play a pivotal role in cell signaling. They are responsible for generating action potential and repolarization. For this reason, dysfunctions of these channels are more and more often associated with the occurrence of both congenital and acquired neurological diseases, such as epilepsies, migraines, ataxias, or neuromyotonia. Clinical symptoms of neuronal ion channel dysfunction differ significantly, reflecting the role and distribution of a given channel in the central and peripheral nervous systems. This paper re-views voltage-gated sodium channel structure, physio

APA, Harvard, Vancouver, ISO, and other styles

18

Levina, N. N., R. R. Lew, and I. B. Heath. "Cytoskeletal regulation of ion channel distribution in the tip-growing organism Saprolegnia ferax." Journal of Cell Science 107, no. 1 (1994): 127–34. http://dx.doi.org/10.1242/jcs.107.1.127.

Full text

Abstract:

Growing hyphal tips of the oomycete Saprolegnia ferax possess a tip-high gradient of stretch-activated ion channels permeable to calcium. These mechanosensitive channels appear to play a direct role in the polarized tip growth process. Treatment of S. ferax hyphae with cytochalasin E leads to the disruption of plasmalemma-associated, peripheral cytoplasmic actin populations and altered morphology of apical protoplasts, and eliminates the tip-high gradient of stretch-activated channels. Cytochalasin E did not alter the normal aggregation of stretch-activated channels. The density of spontaneous

APA, Harvard, Vancouver, ISO, and other styles

19

Ślęczkowska, Milena, Rowida Almomani, Margherita Marchi, et al. "Peripheral Ion Channel Gene Screening in Painful- and Painless-Diabetic Neuropathy." International Journal of Molecular Sciences 23, no. 13 (2022): 7190. http://dx.doi.org/10.3390/ijms23137190.

Full text

Abstract:

Neuropathic pain is common in diabetic peripheral neuropathy (DN), probably caused by pathogenic ion channel gene variants. Therefore, we performed molecular inversion probes-next generation sequencing of 5 transient receptor potential cation channels, 8 potassium channels and 2 calcium-activated chloride channel genes in 222 painful- and 304 painless-DN patients. Twelve painful-DN (5.4%) patients showed potentially pathogenic variants (five nonsense/frameshift, seven missense, one out-of-frame deletion) in ANO3 (n = 3), HCN1 (n = 1), KCNK18 (n = 2), TRPA1 (n = 3), TRPM8 (n = 3) and TRPV4 (n =

APA, Harvard, Vancouver, ISO, and other styles

20

Ortiz, Mario I., Raquel Cariño-Cortés, Víctor M. Muñoz-Pérez, Carlo Eduardo Medina-Solís, and Gilberto Castañeda-Hernández. "Citral inhibits the nociception in the rat formalin test: effect of metformin and blockers of opioid receptor and the NO-cGMP-K⁺ channel pathway." Canadian Journal of Physiology and Pharmacology 100, no. 4 (2022): 306–13. http://dx.doi.org/10.1139/cjpp-2021-0458.

Full text

Abstract:

The objective of the present study was to scrutinize the effect of nitric oxide (NO), cyclic GMP (cGMP), potassium channel blockers, and metformin on the citral-produced peripheral antinociception. The rat paw 1% formalin test was used to assess nociception and antinociception. Rats were treated with local peripheral administration of citral (10–100 µg/paw). The antinociception of citral (100 µg/paw) was evaluated with and without the local pretreatment of naloxone, NG-L-nitro-arginine methyl ester (L-NAME, a NO synthesis inhibitor), 1H-(1,2,4)-oxadiazolo(4,2-a)quinoxalin-1-one (ODQ, a soluble

APA, Harvard, Vancouver, ISO, and other styles

21

Zeng, D., J. W. Kyle, R. L. Martin, K. S. Ambler, and D. A. Hanck. "Cardiac sodium channels expressed in a peripheral neurotumor-derived cell line, RT4-B8." American Journal of Physiology-Cell Physiology 270, no. 5 (1996): C1522—C1531. http://dx.doi.org/10.1152/ajpcell.1996.270.5.c1522.

Full text

Abstract:

RT4-B is one of several cell lines derived from a multipotent stem cell line, RT4-AC, which originated from a rat peripheral neurotumor. Based on Northern blot and ribonuclease protection experiments, RT4-B8 cells have been proposed to express rat cardiac Na channel mRNA as the major isoform. We report here direct electrophysiological evidence that the expressed voltage-gated Na channels in the RT4-B8 cell line are of the cardiac phenotype with no evidence for subpopulations expressing other Na channel isoforms. Current activation half point (conductance) was -41 +/- 5 mV (n = 7) and the stead

APA, Harvard, Vancouver, ISO, and other styles

22

Dionisi, Marianna, Federico Alessandro Ruffinatti, Beatrice Riva, et al. "Early Stimulation of TREK Channel Transcription and Activity Induced by Oxaliplatin-Dependent Cytosolic Acidification." International Journal of Molecular Sciences 21, no. 19 (2020): 7164. http://dx.doi.org/10.3390/ijms21197164.

Full text

Abstract:

Oxaliplatin-induced peripheral neuropathy is characterized by an acute hyperexcitability syndrome triggered/exacerbated by cold. The mechanisms underlying oxaliplatin-induced peripheral neuropathy are unclear, but the alteration of ion channel expression and activity plays a well-recognized central role. Recently, we found that oxaliplatin leads to cytosolic acidification in dorsal root ganglion (DRG) neurons. Here, we investigated the early impact of oxaliplatin on the proton-sensitive TREK potassium channels. Following a 6-h oxaliplatin treatment, both channels underwent a transcription upre

APA, Harvard, Vancouver, ISO, and other styles

23

Triggle, David J. "Calcium, calcium channels, and calcium channel antagonists." Canadian Journal of Physiology and Pharmacology 68, no. 11 (1990): 1474–81. http://dx.doi.org/10.1139/y90-224.

Full text

Abstract:

Voltage-dependent Ca2+ channels are an important pathway for Ca2+ influx in excitable cells. They also represent an important site of action for a therapeutic group of agents, the Ca2+ channel antagonists. These drugs enjoy considerable use in the cardiovascular area including angina, some arrhythmias, hypertension, and peripheral vascular disorders. The voltage-dependent Ca2+ channels exist in a number of subclasses characterized by electrophysiologic, permeation, and pharmacologic criteria. The Ca2+ channel antagonists, including verapamil, nifedipine, and diltiazem, serve to characterize th

APA, Harvard, Vancouver, ISO, and other styles

24

Ortiz, Mario I., Raquel Cariño-Cortés, Eduardo Fernández-Martínez, Victor Manuel Muñoz-Pérez, Gilberto Castañeda-Hernández, and Martha Patricia González-García. "Peripheral Antinociception Induced by Carvacrol in the Formalin Test Involves the Opioid Receptor-NO-cGMP-K+ Channel Pathway." Metabolites 15, no. 5 (2025): 314. https://doi.org/10.3390/metabo15050314.

Full text

Abstract:

Background/Objectives: Carvacrol is a naturally occurring phenolic monoterpene that is one of the main constituents of the essential oils of oregano (Origanum vulgare) and other herbs. Carvacrol has anti-inflammatory and antinociceptive effects. Carvacrol can activate and inhibit several second messengers and ionic channels at the systemic level. However, there is no evidence of the peripheral antinociception of carvacrol and its mechanism of action. This study was designed to determine whether the opioid receptor-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-K+ channel pathway is in

APA, Harvard, Vancouver, ISO, and other styles

25

Strassman, A. M., and S. A. Raymond. "Electrophysiological Evidence for Tetrodotoxin-Resistant Sodium Channels in Slowly Conducting Dural Sensory Fibers." Journal of Neurophysiology 81, no. 2 (1999): 413–24. http://dx.doi.org/10.1152/jn.1999.81.2.413.

Full text

Abstract:

Electrophysiological evidence for tetrodotoxin-resistant sodium channels in mechanosensitive nerve endings of slowly conducting fibers in the intracranial dura. A tetrodotoxin (TTX)-resistant sodium channel was recently identified that is expressed only in small diameter neurons of peripheral sensory ganglia. The peripheral axons of sensory neurons appear to lack this channel, but its presence has not been investigated in peripheral nerve endings, the site of sensory transduction in vivo. We investigated the effect of TTX on mechanoresponsiveness in nerve endings of sensory neurons that innerv

APA, Harvard, Vancouver, ISO, and other styles

26

Kamp, Marcel A., Maxine Dibué, Toni Schneider, Hans-Jakob Steiger, and Daniel Hänggi. "Calcium and Potassium Channels in Experimental Subarachnoid Hemorrhage and Transient Global Ischemia." Stroke Research and Treatment 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/382146.

Full text

Abstract:

Healthy cerebrovascular myocytes express members of several different ion channel families which regulate resting membrane potential, vascular diameter, and vascular tone and are involved in cerebral autoregulation. In animal models, in response to subarachnoid blood, a dynamic transition of ion channel expression and function is initiated, with acute and long-term effects differing from each other. Initial hypoperfusion after exposure of cerebral vessels to oxyhemoglobin correlates with a suppression of voltage-gated potassium channel activity, whereas delayed cerebral vasospasm involves chan

APA, Harvard, Vancouver, ISO, and other styles

27

Gamper, Nikita. "Ion channels in somatosensory transmission: an introduction to the collection." F1000Research 3 (November 14, 2014): 278. http://dx.doi.org/10.12688/f1000research.5729.1.

Full text

Abstract:

Excitation of peripheral endings of sensory nerves is a primary event in most types of somatosensation, including pain. This excitation and transmission of action potentials within somatosensory pathways is brought about by the concerted action of the wide array of plasmalemmal ion channels, some of which are specific to somatosensory nerves. Accordingly, ion channel deficiencies or ‘channelopathies’ often underlie sensory disorders and pathological pain states and many current and prospective analgesics target ion channels. This F1000Research article collection is focused on the current advan

APA, Harvard, Vancouver, ISO, and other styles

28

Chen, Howard. "Muscle Channel Technique for Peripheral Sensory Neuropathy." Medical Acupuncture 22, no. 1 (2010): 57–59. http://dx.doi.org/10.1089/acu.2009.0714.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Handler, Joel. "Managing Calcium Channel Blocker-Related Peripheral Edema." Journal of Clinical Hypertension 6, no. 7 (2004): 400–402. http://dx.doi.org/10.1111/j.1524-6175.2004.02863.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Hoeijmakers, Janneke G. J., Catharina G. Faber, Ingemar S. J. Merkies, and Stephen G. Waxman. "Painful peripheral neuropathy and sodium channel mutations." Neuroscience Letters 596 (June 2015): 51–59. http://dx.doi.org/10.1016/j.neulet.2014.12.056.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Krishnan, Arun V. "Ion channel dysfunction and peripheral nerve hyperexcitability." Clinical Neurophysiology 126, no. 6 (2015): 1069–70. http://dx.doi.org/10.1016/j.clinph.2014.09.012.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Dib-Hajj, Sulayman D., and Stephen G. Waxman. "Sodium Channels in Human Pain Disorders: Genetics and Pharmacogenomics." Annual Review of Neuroscience 42, no. 1 (2019): 87–106. http://dx.doi.org/10.1146/annurev-neuro-070918-050144.

Full text

Abstract:

Acute pain is adaptive, but chronic pain is a global challenge. Many chronic pain syndromes are peripheral in origin and reflect hyperactivity of peripheral pain-signaling neurons. Current treatments are ineffective or only partially effective and in some cases can be addictive, underscoring the need for better therapies. Molecular genetic studies have now linked multiple human pain disorders to voltage-gated sodium channels, including disorders characterized by insensitivity or reduced sensitivity to pain and others characterized by exaggerated pain in response to normally innocuous stimuli.

APA, Harvard, Vancouver, ISO, and other styles

33

Luu, Wing, James Bjork, Erin Salo, et al. "Modulation of SUR1 KATP Channel Subunit Activity in the Peripheral Nervous System Reduces Mechanical Hyperalgesia after Nerve Injury in Mice." International Journal of Molecular Sciences 20, no. 9 (2019): 2251. http://dx.doi.org/10.3390/ijms20092251.

Full text

Abstract:

The ATP-sensitive K+ channel (KATP) is involved in hypersensitivity during chronic pain and is presumed to be a downstream target of mu opioid receptors. Multiple subtypes of KATP channels exist in the peripheral and central nervous system and their activity may be inversely correlated to chronic pain phenotypes in rodents. In this study, we investigated the different KATP channel subunits that could be involved in neuropathic pain in mice. In chronic pain models utilizing spinal nerve ligation, SUR1 and Kir6.2 subunits were found to be significantly downregulated in dorsal root ganglia and th

APA, Harvard, Vancouver, ISO, and other styles

34

Bujak, Joanna K., Daria Kosmala, Kinga Majchrzak-Kuligowska, and Piotr Bednarczyk. "Functional Expression of TRPV1 Ion Channel in the Canine Peripheral Blood Mononuclear Cells." International Journal of Molecular Sciences 22, no. 6 (2021): 3177. http://dx.doi.org/10.3390/ijms22063177.

Full text

Abstract:

TRPV1, known as a capsaicin receptor, is the best-described transient receptor potential (TRP) ion channel. Recently, it was shown to be expressed by non-excitable cells such as lymphocytes. However, the data regarding the functional expression of the TRPV1 channel in the immune cells are often contradictory. In the present study, we performed a phylogenetical analysis of the canine TRP ion channels, we assessed the expression of TRPV1 in the canine peripheral blood mononuclear cells (PBMC) by qPCR and Western blot, and we determined the functionality of TRPV1 by whole-cell patch-clamp recordi

APA, Harvard, Vancouver, ISO, and other styles

35

Hampl, Václav, Jana Bı́bová, Zbynek Straňák, et al. "Hypoxic fetoplacental vasoconstriction in humans is mediated by potassium channel inhibition." American Journal of Physiology-Heart and Circulatory Physiology 283, no. 6 (2002): H2440—H2449. http://dx.doi.org/10.1152/ajpheart.01033.2001.

Full text

Abstract:

Fetal to maternal blood flow matching in the placenta, necessary for optimal fetal blood oxygenation, may occur via hypoxic fetoplacental vasoconstriction (HFPV). We hypothesized that HFPV is mediated by K+ channel inhibition in fetoplacental vascular smooth muscle, as occurs in several other O2-sensitive tissues. With the use of an isolated human placental cotyledon perfused at a constant flow rate, we found that hypoxia reversibly increased perfusion pressure by >20%. HFPV was unaffected by cyclooxygenase or nitric oxide synthase inhibition. HFPV and 4-aminopyridine, an inhibitor of volta

APA, Harvard, Vancouver, ISO, and other styles

36

Mendelowitz, D., P. J. Reynolds, and M. C. Andresen. "Heterogeneous functional expression of calcium channels at sensory and synaptic regions in nodose neurons." Journal of Neurophysiology 73, no. 2 (1995): 872–75. http://dx.doi.org/10.1152/jn.1995.73.2.872.

Full text

Abstract:

1. In the present study we have taken advantage of the unique anatomy of visceral sensory neurons that enabled us to isolate and examine the role of calcium channel subtypes at the soma, central synaptic terminals, and peripheral sensory endings. 2. N-type calcium channels dominated somatic currents (60%), with lesser (16% and 12%) contributions from P- and L-type channels, respectively, in patch-clamped dispersed nodose neurons using toxins selective for each calcium channel subtype. 3. These toxins also blocked the release of neurotransmitters from these visceral synaptic terminals in a brai

APA, Harvard, Vancouver, ISO, and other styles

37

Cochrane, Veronica, та Show-Ling Shyng. "Leptin-induced Trafficking of KATP Channels: A Mechanism to Regulate Pancreatic β-cell Excitability and Insulin Secretion". International Journal of Molecular Sciences 20, № 11 (2019): 2660. http://dx.doi.org/10.3390/ijms20112660.

Full text

Abstract:

The adipocyte hormone leptin was first recognized for its actions in the central nervous system to regulate energy homeostasis but has since been shown to have direct actions on peripheral tissues. In pancreatic β-cells leptin suppresses insulin secretion by increasing KATP channel conductance, which causes membrane hyperpolarization and renders β-cells electrically silent. However, the mechanism by which leptin increases KATP channel conductance had remained unresolved for many years following the initial observation. Recent studies have revealed that leptin increases surface abundance of KAT

APA, Harvard, Vancouver, ISO, and other styles

38

Kaneko, Hiroshi, Frank Möhrlen, and Stephan Frings. "Calmodulin Contributes to Gating Control in Olfactory Calcium-activated Chloride Channels." Journal of General Physiology 127, no. 6 (2006): 737–48. http://dx.doi.org/10.1085/jgp.200609497.

Full text

Abstract:

In sensory neurons of the peripheral nervous system, receptor potentials can be amplified by depolarizing Cl currents. In mammalian olfactory sensory neurons (OSNs), this anion-based signal amplification results from the sequential activation of two distinct types of transduction channels: cAMP-gated Ca channels and Ca-activated Cl channels. The Cl current increases the initial receptor current about 10-fold and leads to the excitation of the neuron. Here we examine the activation mechanism of the Ca-dependent Cl channel. We focus on calmodulin, which is known to mediate Ca effects on various

APA, Harvard, Vancouver, ISO, and other styles

39

Becker, Gabriela, Maria Fernanda Pessano Fialho, Evelyne Silva Brum, and Sara Marchesan Oliveira. "Kinin B2 Receptor Mediates Cisplatin-Induced Painful Peripheral Neuropathy by Intracellular Kinase Pathways and TRPA1 Channel Sensitisation." Pharmaceuticals 16, no. 7 (2023): 959. http://dx.doi.org/10.3390/ph16070959.

Full text

Abstract:

Chemotherapy-induced peripheral neuropathy is a severe clinical problem frequently associated with cisplatin use. Although its pathophysiology is poorly understood, it is known that kinin receptors and the transient receptor potential ankyrin 1 (TRPA1) channel play a significant role in the peripheral neuropathy induced by cisplatin in rodents. However, the role of signalling pathways downstream from B2 kinin receptors activation and sensitisation of the TRPA1 channel remains unknown in this model. The cisplatin-induced neuropathy model caused mechanical and cold allodynia in male Swiss mice.

APA, Harvard, Vancouver, ISO, and other styles

40

Adams, Christopher M., Michael G. Anderson, David G. Motto, Margaret P. Price, Wayne A. Johnson, and Michael J. Welsh. "Ripped Pocket and Pickpocket, Novel Drosophila DEG/ENaC Subunits Expressed in Early Development and in Mechanosensory Neurons." Journal of Cell Biology 140, no. 1 (1998): 143–52. http://dx.doi.org/10.1083/jcb.140.1.143.

Full text

Abstract:

Drosophila melanogaster has proven to be a good model for understanding the physiology of ion channels. We identified two novel Drosophila DEG/ ENaC proteins, Pickpocket (PPK) and Ripped Pocket (RPK). Both appear to be ion channel subunits. Expression of RPK generated multimeric Na+ channels that were dominantly activated by a mutation associated with neurodegeneration. Amiloride and gadolinium, which block mechanosensation in vivo, inhibited RPK channels. Although PPK did not form channels on its own, it associated with and reduced the current generated by a related human brain Na+ channel. R

APA, Harvard, Vancouver, ISO, and other styles

41

McKinnon, D., and R. Ceredig. "Changes in the expression of potassium channels during mouse T cell development." Journal of Experimental Medicine 164, no. 6 (1986): 1846–61. http://dx.doi.org/10.1084/jem.164.6.1846.

Full text

Abstract:

In this report we have combined the whole-cell electrophysiological recording technique with flow microfluorometry to isolate phenotypically defined thymocytes and T lymphocytes. Results obtained showed that J11d-/Lyt-2-/L3T4- cells express none or very few delayed rectifier K+ channels, whereas most other Lyt-2-/L3T4- cells, as well as typical cortical thymocytes (Lyt-2+/L3T4+), do express K+ channels. Mature (Lyt-2+/L3T4- or Lyt-2-/L3T4+) thymocytes, which are heterogeneous for J11d expression, were also found to be heterogeneous for K+ channel expression. Consistent with this finding was th

APA, Harvard, Vancouver, ISO, and other styles

42

Gudlavalleti, R. H., B. Saman, R. Mays, Evan Heller, J. Chandy, and F. Jain. "A Novel Peripheral Circuit for SWSFET Based Multivalued Static Random-Access Memory." International Journal of High Speed Electronics and Systems 29, no. 01n04 (2020): 2040010. http://dx.doi.org/10.1142/s0129156420400108.

Full text

Abstract:

This paper presents the peripheral circuitry for a multivalued static random-access memory (SRAM) based on 2-bit CMOS cross-coupled inverters using spatial wavefunction switched (SWS) field effect transistors (SWSFETs). The novel feature is a two quantum well/quantum dot channel n-SWSFET access transistor. The reduction in area with four-bit storage-per-cell increases the memory density and efficiency of the SRAM array. The SWSFET has vertically stacked two-quantum well/quantum dot channels between the source and drain regions. The upper or lower quantum charge locations in the channel region

APA, Harvard, Vancouver, ISO, and other styles

43

Kellenberger, Stephan, and Laurent Schild. "Epithelial Sodium Channel/Degenerin Family of Ion Channels: A Variety of Functions for a Shared Structure." Physiological Reviews 82, no. 3 (2002): 735–67. http://dx.doi.org/10.1152/physrev.00007.2002.

Full text

Abstract:

The recently discovered epithelial sodium channel (ENaC)/degenerin (DEG) gene family encodes sodium channels involved in various cell functions in metazoans. Subfamilies found in invertebrates or mammals are functionally distinct. The degenerins in Caenorhabditis elegansparticipate in mechanotransduction in neuronal cells, FaNaC in snails is a ligand-gated channel activated by neuropeptides, and the Drosophila subfamily is expressed in gonads and neurons. In mammals, ENaC mediates Na+ transport in epithelia and is essential for sodium homeostasis. The ASIC genes encode proton-gated cation chan

APA, Harvard, Vancouver, ISO, and other styles

44

White, JG. "The secretory pathway of bovine platelets." Blood 69, no. 3 (1987): 878–85. http://dx.doi.org/10.1182/blood.v69.3.878.878.

Full text

Abstract:

Abstract Human platelets contain tortuous channels in their cytoplasm, the surface-connected or open canalicular system (OCS), that communicate directly with the surrounding medium through openings on the surface membrane. Some workers have suggested that the OCS serves as the egress route for products secreted during the release reaction. Others have proposed alternate secretory pathways. Since bovine platelets lack the OCS found in human cells, the present study has examined the secretory mechanism of these cells to see whether it can shed light on the mystery of human platelet secretion. Bo

APA, Harvard, Vancouver, ISO, and other styles

45

White, JG. "The secretory pathway of bovine platelets." Blood 69, no. 3 (1987): 878–85. http://dx.doi.org/10.1182/blood.v69.3.878.bloodjournal693878.

Full text

Abstract:

Human platelets contain tortuous channels in their cytoplasm, the surface-connected or open canalicular system (OCS), that communicate directly with the surrounding medium through openings on the surface membrane. Some workers have suggested that the OCS serves as the egress route for products secreted during the release reaction. Others have proposed alternate secretory pathways. Since bovine platelets lack the OCS found in human cells, the present study has examined the secretory mechanism of these cells to see whether it can shed light on the mystery of human platelet secretion. Bovine plat

APA, Harvard, Vancouver, ISO, and other styles

46

Newsom-Davis, John. "Autoantibody-Mediated Channelopathies at the Neuromuscular Junction." Neuroscientist 3, no. 5 (1997): 337–46. http://dx.doi.org/10.1177/107385849700300515.

Full text

Abstract:

The neuromuscular junction is vulnerable to antibody-mediated autoimmune attack, probably because it lacks the protection of the blood-brain barrier. This review focuses on three disorders: myasthenia gravis (MG) and the Lambert-Eaton myasthenic syndrome (LEMS), in both of which there is fatiguable muscle weakness, and acquired neuromyotonia (ANMT), in which hyperexcitable peripheral nerves lead to continuous muscle fiber activity and sometimes parasthesias. Each can occur as a paraneoplastic disorder (thymoma in MG and ANMT, and small cell lung cancer in LEMS). The clinical abnormalities are

APA, Harvard, Vancouver, ISO, and other styles

47

Liu, Xin, Zikang Jiang, Chunhui Niu, Xiaoying Li, Yong Lv, and Jun Chang. "Infrared Imaging System with a Local Polarization Channel for Target Detection." Applied Sciences 14, no. 22 (2024): 10659. http://dx.doi.org/10.3390/app142210659.

Full text

Abstract:

Infrared imaging can detect the targets from their backgrounds during the day and night. As a supplementary tool, polarization imaging can visually characterize the polarized information of targets in complicated environments. In this study, an infrared imaging system with a local polarization channel is developed and simulated. The system can acquire local infrared and polarization information of the target without compromising the monitoring of the entire field of view. This system is composed of two infrared imaging channels with a common image plane: a peripheral channel for the entire fie

APA, Harvard, Vancouver, ISO, and other styles

48

Bouyer, Guillaume, Anne Cueff, Stéphane Egée, et al. "Erythrocyte peripheral type benzodiazepine receptor/voltage-dependent anion channels are upregulated by Plasmodium falciparum." Blood 118, no. 8 (2011): 2305–12. http://dx.doi.org/10.1182/blood-2011-01-329300.

Full text

Abstract:

Abstract Plasmodium falciparum relies on anion channels activated in the erythrocyte membrane to ensure the transport of nutrients and waste products necessary for its replication and survival after invasion. The molecular identity of these anion channels, termed “new permeability pathways” is unknown, but their currents correspond to up-regulation of endogenous channels displaying complex gating and kinetics similar to those of ligand-gated channels. This report demonstrates that a peripheral-type benzodiazepine receptor, including the voltage dependent anion channel, is present in the human

APA, Harvard, Vancouver, ISO, and other styles

49

Essin, Kirill, Birgit Salanova, Ralph Kettritz, et al. "Large-conductance calcium-activated potassium channel activity is absent in human and mouse neutrophils and is not required for innate immunity." American Journal of Physiology-Cell Physiology 293, no. 1 (2007): C45—C54. http://dx.doi.org/10.1152/ajpcell.00450.2006.

Full text

Abstract:

Large-conductance Ca2+-activated K+(BK) channels are reported to be essential for NADPH oxidase-dependent microbial killing and innate immunity in leukocytes. Using human peripheral blood and mouse bone marrow neutrophils, pharmacological targeting, and BK channel gene-deficient (BK−/−) mice, we stimulated NADPH oxidase activity with 12- O-tetradecanoylphorbol-13-acetate (PMA) and performed patch-clamp recordings on isolated neutrophils. Although PMA stimulated NADPH oxidase activity as assessed by O2−and H2O2production, our patch-clamp experiments failed to show PMA-activated BK channel curre

APA, Harvard, Vancouver, ISO, and other styles

50

Marmoy, Oliver R., Paul L. Furlong, and Christopher E. G. Moore. "Upper and lower limb motor axons demonstrate differential excitability and accommodation to strong hyperpolarizing currents during induced hyperthermia." Journal of Neurophysiology 121, no. 6 (2019): 2061–70. http://dx.doi.org/10.1152/jn.00464.2018.

Full text

Abstract:

Length-dependent peripheral neuropathy typically involves the insidious onset of sensory loss in the lower limbs before later progressing proximally. Recent evidence proposes hyperpolarization-activated cyclic nucleotide-gated (HCN) channels as dysfunctional in rodent models of peripheral neuropathy, and therefore differential expression of HCN channels in the lower limbs was hypothesized as a pathophysiological mechanism accounting for the pattern of symptomatology within this study. We studied six healthy participants, using motor axon excitability including strong and long [−70% and −100% h

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!