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Dissertations / Theses on the topic 'Peripheral inflammation'

Author: Grafiati

Published: 31 August 2024

Last updated: 19 July 2025

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1

Chapman, Katie. "Peripheral inflammation after experimental stroke." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518434.

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2

McColl, Alison. "The brain response to peripheral inflammation." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6764/.

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Communication between the immune system and the central nervous system (CNS) is becoming increasingly topical as evidence suggests the two systems are intricately linked. Although the brain is considered an ‘immune-specialised’ tissue, it is not free from the influences of the periphery. Recent data indicate that peripheral immune stimulation can significantly affect the CNS, and patients with chronic inflammatory diseases, including rheumatoid arthritis (RA) and psoriasis, are often further burdened by the onset of neuropsychiatric conditions such as major depressive disorder (MDD), schizophr

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3

Adeoye, Opeolu M. D. "Peripheral Leukocytes and Intracerebral Hemorrhage." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1353100438.

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4

Jiang, Yanyan. "The role of peripheral TNF in acute brain inflammation." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496980.

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5

Barr, Laura Caroline. "Peripheral blood mononuclear cell depletion for experimental human lung inflammation." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/23705.

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Acute lung injury (ALI) affects a significant proportion of patients requiring critical care and is associated with high morbidity and mortality. Treatment is currently only supportive, with no pharmacological treatment yet shown to definitively improve outcome. There is evidence from murine models of ALI that monocytes play a key role in the development of the neutrophilic lung infiltration characteristic of ALI. Depletion of blood monocytes in mice given intra-tracheal lipopolysaccharide (LPS) significantly reduces pulmonary neutrophil influx, systemic neutrophilia and other markers of lung

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6

Karim, Salman. "Peripheral and central markers of inflammation in mild cognitive impairment." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/peripheral-and-central-markers-of-inflammation-in-mild-cognitive-impairment(bd21dafe-65c1-42c9-949b-733abfc71037).html.

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There has been accumulating scientific evidence, over the last three decades, of the role of inflammatory processes in the development of Alzheimer's disease (AD). Population based studies suggest that plasma levels of inflammatory markers are raised in peripheral blood of people with AD. People on long term use of non-steroidal anti-inflammatory drugs have a lower prevalence of AD. Moreover, both animal and human histopathology studies have reported localization of inflammation in brain areas primarily affected by AD pathology. Areas of increased inflammation can be visualized in vivo by Posi

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7

Thomson, Carolyn. "Peripheral inflammation remotely triggers global gene expression changes in the brain." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5390/.

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Although the central nervous system (CNS) was once considered an immunologically privileged site, in recent years it has become increasingly evident that cross talk between the immune system and the CNS does occur. As a result, patients with chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease or psoriasis are often further burdened with neuropsychiatric symptoms such as depression, anxiety and fatigue. Despite the recent advances in our understanding of neuroimmune communication pathways, the precise effect peripheral immune activation has on neural circuitry

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8

Tzoulaki, Ioanna. "Inflammation and haemostasis in the development and progression of peripheral atherosclerotic disease." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/2148.

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Peripheral arterial disease (PAD) defines atherosclerotic disease of the arteries to the legs. PAD begins early in life and remains asymptomatic over long periods. The ankle brachial index (ABI) is an important diagnostic test which can identify asymptomatic individuals and serve as a good marker of the underlying peripheral and systemic atherosclerosis. Recent advances in vascular biology proposed a role of inflammatory and haemostatic mechanisms in atherosclerotic disease. Although inflammatory and haemostatic markers have been associated with coronary atherosclerosis in large scale epidemio

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9

Parmar, Jiteshkumar H. "The role of inflammation in ischaemia reperfusion injury due to peripheral arterial revascularisation." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509840.

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10

Hau, Vincent Sinh. "EFFECT OF PERIPHERAL INFLAMMATORY PAIN ON THE BLOOD-BRAIN BARRIER." Diss., Tucson, Arizona : University of Arizona, 2005. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1071%5F1%5Fm.pdf&type=application/pdf.

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11

RUSCONI, MICHELA. "Activation state and functionality of dendritic cells from peripheral blood of amyotrophic lateral sclerosis patients." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2017. http://hdl.handle.net/10281/153236.

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Molti dati pubblicati sottolineano l’importanza dell’infiammazione per la neurodegenerazione nella sclerosi laterale amiotrofica (SLA) con un aumento del reclutamento al midollo spinale dei monociti periferici, delle cellule dendritiche (DCs) e delle cellule T in modelli murini e nell’uomo. Ad oggi non ci sono dati circa lo stato funzionale delle DCs nel sangue periferico dei pazienti SLA. Lo scopo dello studio è esaminare le DCs circolanti in una coorte di pazienti SLA prendendo in considerazione la loro storia clinica, per capire come queste cellule contribuiscano alla progressione della p

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12

Burdess, Anne. "Role of inflammation and platelet activation in the adverse cardiovascular outcomes of patients undergoing surgery for critical limb ischaemia." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9539.

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Increased platelet activation and inflammation play a key role in atherothrombosis. Patients with peripheral arterial disease are at increased risk of adverse cardiovascular events, particularly at the time of surgery. We postulated that the increase in peri-operative cardiovascular events is mediated by increased platelet activation and inflammation. We hypothesized that peri-operative dual anti-platelet therapy would improve biomarkers of atherothrombosis without causing unacceptable bleeding in patients undergoing surgery for critical limb ischaemia (CLI). Prior to interventional study, I v

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13

Araújo, Lucas Guilherme de. "On cholecystokinin-opioid interaction in the spinal dorsal horn following peripheral nerve injury and inflammation /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3560-2/.

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14

Lavinskienė, Simona. "Peripheral blood neutrophil and eosinophil activity during allergen-induced late-phase airway inflammation in asthma." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2015. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20150106_083713-90371.

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There is no doubt that eosinophils and neutrophils are important cells participating in asthma pathogenesis. The most prominent feature reflecting asthma pathogenesis is late-phase airway inflammation, which occurs a few hours after allergen inhalation. The worldwide published studies on asthma show that most attention is paid to individual, not complex, functions of neutrophils and eosinophils in the airways. Moreover, associations between peripheral blood neutrophil and eosinophil activity and infiltration of these cells in the airways during asthma have not been com¬pletely elucidated yet.

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15

Komla, Essie S. "Antinociceptive tolerance to morphine is driven by colonic inflammation and mediated by peripheral opioid receptors." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5818.

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Opioids are powerful analgesics. Despite their high efficacy for the management of moderate to severe pain, their clinical utility is limited due to the occurrence of adverse effects. The main problem associated with opioid use is the differential rate of tolerance development to the various pharmacological effects of opioids, with tolerance to respiratory depression occurring at a slower rate than analgesic and euphoric effects. The development of analgesic tolerance, where the efficacy of the drug progressively diminishes with repeated administration, requires higher doses of the drug to ach

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16

Cristante, Enrico. "Impact of peripheral inflammation in the brain : new roles for the anti-inflammatory molecule Annexin A1." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/14415.

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Growing evidence has shown that peripheral inflammation can trigger a central nervous system response, sometimes worsening pre-existing neurological conditions, breaking down the concept of brain as an immune-privileged organ. Understanding which components contribute to periphery-to-brain communication may help identify molecules exploitable for therapeutic intervention. Usually, inflammation is followed by resolution: one of the main effectors in this process during peripheral inflammation is Annexin A1, while its implications in the CNS are still unclear. This thesis provides evidence for a

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17

Jäger, Amelie [Verfasser], and Christine [Akademischer Betreuer] Dierks. "JAK Pathway inhibition as a novel therapeutic strategy in peripheral t-cell lymphomas with associated inflammation." Freiburg : Universität, 2018. http://d-nb.info/1216826420/34.

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18

Riester, Karin Dorota [Verfasser]. "The effect of peripheral inflammation on in vivo functional properties of cortical networks / Karin Dorota Riester." Tübingen : Universitätsbibliothek Tübingen, 2020. http://d-nb.info/1217249265/34.

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19

Hernández, Aguilera Anna. "Peripheral Artery Disease: The search for a biological marker." Doctoral thesis, Universitat Rovira i Virgili, 2017. http://hdl.handle.net/10803/442958.

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La malaltia arterial perifèria (MAP) és una manifestació comuna de l'aterosclerosi sistèmica que afecta les artèries perifèriques. Tot i la seva elevada prevalença, la MAP està infradiagnosticada perquè els primers estadis de la malaltia són asimptomàtics. Tot i les seves limitacions, l’índex turmell-braç és el test usat per al diagnòstic. Hi ha altres biomarcadors circulants però són per a l’aterosclerosi en general. La inflamació, l’oxidació, la remodelació vascular i la disfunció mitocondrial tenen un paper clau en el desenvolupament de l’aterosclerosi. Creiem que un millor coneixement d’a

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20

Doak, Gregory J. "Peripheral mechanisms of adenosine and 5-hydroxytryptamine contributing to nociception and inflammation in the rat formalin model." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq24735.pdf.

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21

Pitcher, Mark Henry. "Role of the NKCC1 co-transporter in spinal nociceptive mechanisms in a rodent model of peripheral inflammation." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=96700.

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The Gate Control Theory describes a spinal circuit whereby activity in low threshold mechano-sensitive fibers attenuates activity in nociceptive fibers, such that innocuous touch eases pain. Paradoxically, for many chronic pain sufferers, lightly touching the injured (primary) region or adjacent uninjured (secondary) region may evoke pain rather than ease pain, phenomena referred to as primary and secondary allodynia, respectively. We hypothesize that enhanced activity of the NKCC1 chloride co-transporter in persistent pain states may underlie this effect. NKCC1 is the main chloride accumulato

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22

Wendeln, Ann-Christin [Verfasser]. "Long-lasting epigenetic microglial memory of peripheral inflammation modulates hallmarks of Alzheimer's disease pathology / Ann-Christin Wendeln." Tübingen : Universitätsbibliothek Tübingen, 2020. http://d-nb.info/1217249214/34.

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23

Marimuthu, Rekha. "Study of Monocytes in Diabetic Foot Ulcer (DFU) patients with Peripheral Arterial Disease (PAD)." Thesis, The University of Sydney, 2018. https://hdl.handle.net/2123/21374.

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Diabetic foot ulcers (DFUs) are one common and severe complication of diabetes, showing impaired wound healing. Peripheral arterial disease (PAD), which is common in diabetes, increases the severity of DFUs leading to delayed or unsuccessful healing. Prolonged inflammation is one of the likely contributors to this, with an imbalance in macrophage phenotypes seen in diabetes. Monocytes, precursors to macrophages, express M1/M2 macrophage markers indicating monocyte skewing to a particular macrophage phenotype begins in the circulation. Whether the presence of DFU is associated with monocyte M1-

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24

Bernards, Nicholas. "PET molecular imaging of peripheral and central inflammatory processes targeting the TSPO 18 kDa." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112211/document.

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L’objectif de la thèse: À ce jour, il est admis que la TSPO joue un rôle important dans le processus inflammatoire, et qu’il est possible de suivre sa présence à l’aide d’une variété de radiotraceurs adaptés. Les impacts de l’inflammation touchent un grand nombre de personnes à travers le monde pour diverses raisons ; c’est pourquoi, quoique le [ ¹ ⁸F]DPA-714 est très prometteur, il est nécessaire d’aller plus loin pour explorer ses capacités et ses applications possibles. L’inflammation a une forte incidence sur différentes maladies, par conséquent, à impact social élevé (comme la maladie inf

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25

Rankin, Gregory. "Investigation of the role of IgE-dependent cytokine release from human peripheral lung tissue in allergic lung inflammation." Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/378565/.

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26

Parkinson, Sarah. "Neuroinflammation, Peripheral Inflammation and Gut Microbiome Profiles in Male Mice from Two Proposed Mouse Models of Social Behavior Deficits." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/etd/3972.

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Autism spectrum disorder (ASD) is a neurodevelopmental disorder marked by social deficits and repetitive actions. A communication pathway exists between the brain and gut called the gut-brain axis. It is thought that gut bacteria can secrete signaling molecules, triggering inflammation across the body. These studies attempt to determine if markers are expressed in two mouse models of ASD behaviors, BTBR and a valproic acid model. Immunohistochemistry of ionized calcium binding adaptor molecule 1 from male mouse brain tissue showed no microglial activation in any group. Cytokine analysis did ex

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27

Pitcher, Mark H. "The effects of persistent peripheral inflammation on the ultrastructural localization of spinal cord dorsal horn group I metabotropic glutamate receptors /." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98770.

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Persistent peripheral inflammation is thought to induce functional plasticity of spinal dorsal horn neurons, and may produce changes in glutamate receptor expression. Alterations in expression and cellular localization of group I metabotropic glutamate receptors (mGluR1alpha and mGIuR5) is important in various neuronal systems, and these receptors are also known to modulate nociceptive neurotransmission in the spinal dorsal horn. The aim of the present study is to determine whether persistent inflammation produces alterations in ultrastructural localization of mGluR1alpha and mGluR5 in the dor

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28

Gelinas, Jinelle Crystal Marie. "The effects of aerobic exercise training on peripheral vascular structure and function and inflammation in patients with Chronic Obstructive Pulmonary Disease." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/45454.

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COPD is associated with chronic systemic inflammation that has been linked to an increased risk of atherosclerosis, ischemic heart disease, and stroke. Endothelial dysfunction, vascular remodeling and arterial stiffness are early processes in the pathogenesis of atherosclerosis and are predictive of future cardiovascular events. Aerobic exercise training can reduce the risk of cardiovascular disease in patients with other chronic conditions. However, little is known about the benefits of exercise for improving vascular health in patients with COPD. Ten non-smoking patients with COPD (mean age=

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Carroll, Mark. "A stereological study assessing the validity of using endobronchial biopsies to assess mast cell density in the central and peripheral bronchial tree." University of Western Australia. School of Medicine and Pharmacology, 2008. http://theses.library.uwa.edu.au/adt-WU2009.0005.

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[Tuncated abstract] There has been longstanding concern over whether endobronchial biopsies adequately represent inflammation throughout the bronchial tree in diseases such as asthma, despite the endobronchial biopsy technique having been used frequently to assess airway inflammation in research settings. There has also been ongoing debate about whether endobronchial biopsies should be assessed by new, unbiased, three-dimensional (3D) stereological techniques instead of traditional, two-dimensional (2D) non-stereological techniques. Therefore, the aims of this study were: (i) to investigate wh

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Tarkowski, M. S. "ANALYSIS OF THE FREQUENCIES OF CD235A+CD71+ PRE-ERYTHROID CELLS IN PERIPHERAL BLOOD AND THEIR FUNCTION IN HIV INFECTED PEOPLE." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/487852.

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Le cellule pre-eritroidi, caratterizzate dall’espressione di glicoforina A (CD235a) e recettore della transferrina (CD71) sono state precedentemente indicate in grado di modulare la risposta immunitaria e inibire la reazione infiammatoria. Poiché il processo dell’eritropoiesi è spesso alterato nel corso dell’infezione da HIV, è stato ipotizzato che le cellule pre-eitroidi, assenti in condizioni normali nel circolo periferico di adulti sani, possano essere riscontrate in soggetti con infezione da HIV ed esercitare un’attività immunomodulatoria. Lo scopo di questo studio è stato di investigare

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Pisi, Paula Carolina Bezzan. "Influência da perda de peso induzida por cirurgia bariátrica na resposta imune em paciente com obesidade grau III." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17138/tde-06062017-163504/.

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A inflamação associada à obesidade é caracterizada por uma ativação crônica e de baixa intensidade do sistema imune. Diversos autores demonstraram mudanças em parâmetros inflamatórios após perda de peso. A cirurgia bariátrica é um método para tratar obesidade com alta eficiência e menor risco de recidiva. Os mononucleares de sangue periférico (MNSP) constituem um material biológico interessante para pesquisa, visto a capacidade de refletir alterações de expressão gênica de diferentes tecidos e o fácil acesso para análise. O presente estudo teve por objetivo avaliar os efeitos da obesidade e da

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Quinteiro, Mariana da Silva 1982. "Evaluation of peripheral effect of 15d-PGJ2 on inflammatory process induced by rheumatoid arthritis into rats' temporomandibular joint = Avaliação do efeito periférico da 15d-PGJ2 no processo inflamatório induzido pela artrite reumatoide na articulação temporomandibular de ratos." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/289486.

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Orientador: Juliana Trindade Clemente Napimoga<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-24T16:30:34Z (GMT). No. of bitstreams: 1 Quinteiro_MarianadaSilva_D.pdf: 18806737 bytes, checksum: 28c4cd737128e1c9696fdffe0daafeac (MD5) Previous issue date: 2014<br>Resumo: O processo inflamatório induzido pela Artrite Reumatoide (AR) na articulação temporomandibular (ATM) resulta em uma dor persistente causando estresse em muitos pacientes. ... Observação: O resumo, na íntegra, poderá ser visualizado no texto

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Wachtel, Nikolaus Constantin [Verfasser]. "Polyunsaturated fatty acids, colorectal cancer, and inflammation: Effects of three major polyunsaturated fatty acids on the lipid metabolism of colorectal adenocarcinoma HT-29 cells and on the cytokine secretion by peripheral blood mononuclear cells / Nikolaus Constantin Wachtel." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2020. http://d-nb.info/1218076240/34.

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Martinez, Caroline Silveira. "Efeitos da exposição ao alumínio sobre parâmetros neurológicos, reprodutores, cardiovasculares e bioquímicos em ratos." Universidade Federal do Pampa, 2017. http://dspace.unipampa.edu.br:8080/jspui/handle/riu/3363.

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Submitted by Marcos Anselmo (marcos.anselmo@unipampa.edu.br) on 2018-09-24T15:40:23Z No. of bitstreams: 1 CAROLINE MARTINEZ.pdf: 15483260 bytes, checksum: 336be2ac82e6f35a3e3945f6a2b3b533 (MD5)<br>Approved for entry into archive by Marcos Anselmo (marcos.anselmo@unipampa.edu.br) on 2018-09-24T15:48:42Z (GMT) No. of bitstreams: 1 CAROLINE MARTINEZ.pdf: 15483260 bytes, checksum: 336be2ac82e6f35a3e3945f6a2b3b533 (MD5)<br>Made available in DSpace on 2018-09-24T15:48:42Z (GMT). No. of bitstreams: 1 CAROLINE MARTINEZ.pdf: 15483260 bytes, checksum: 336be2ac82e6f35a3e3945f6a2b3b533 (MD5) Previo

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Janahi, Noor. "The role of pro-inflammatoy cytokines and autoimmune antibodies in diabetic peripheral neuropathy." Thesis, Queen Margaret University, 2014. https://eresearch.qmu.ac.uk/handle/20.500.12289/7430.

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Introduction – The pathogenetic vision of diabetes mellitus has changed in the last few years, with inflammatory and autoimmunity pathways playing roles in the development and progression of diabetic complications. This study was conducted to investigate whether inflammation and/or autoimmunity are associated with the pathogenesis of human diabetic peripheral neuropathy. Methods – A cross-sectional analysis was initially conducted to explore the population of patients with diabetes mellitus in the Kingdom of Bahrain. The demographics of patients diagnosed with diabetes mellitus in the Royal Me

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Kuster, Robin. "Modulation sexe-dépendante du traitement des informations nociceptives par l'inhibition GABAergique spinale." Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ016.

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La plasticité à court-terme des synapses GABAergiques dans la lamina II de la moelle épinière est essentielle pour le traitement des messages nociceptifs. Cette plasticité diffère selon le type de neurone postsynaptique, excitateur ou inhibiteur. Nos résultats indiquent une modulation liée au sexe de la transmission synaptique GABAergique, et donc une modification de la plasticité des synapses GABAergiques, notamment en réponse à une inflammation périphérique aiguë. Ces modulations soulignent l'importance de la balance entre l’inhibition et l’excitation dans le traitement des informations noci

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Marques, Fernanda Cristina Gomes de Sousa. "The choroid plexus as a sensor of peripheral inflammation." Doctoral thesis, 2008. http://hdl.handle.net/1822/8942.

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Tese de Doutoramento Ciências da Saúde - Ciências Biológicas e Biomédicas<br>Particular interest has been raised in the last few years, regarding the contribution of the immune system in neurological and psychiatric diseases. It is recognized that an inflammatory component underlies disorders such as Alzheimer’s disease and multiple sclerosis. However, whether these are a consequence, a cause, or just a trigger of disease progression remains to be clarified. In this context, understanding how peripheral inflammatory stimulus reach the brain may contribute to better understand the mechanis

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Arioli, Jessica. "TIM-1 glycoprotein mediates neutrophil peripheral recruitment during inflammation." Doctoral thesis, 2020. http://hdl.handle.net/11562/1017959.

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In the last decade, the T cell immunoglobulin and mucin domain 1 (TIM-1) has emerged as a key regulator of innate and adaptive immune responses, representing a promising therapeutic target to be investigated. TIM-1 is widely distributed across immune cells, such as T, B and dendritic cells, where it exerts multiple functions. Despite being well investigated in cancer, transplantation, atopic and autoimmune diseases, several functional aspects of TIM-1 are still unclear. Recently, we have shown a novel function for TIM-1 as adhesion receptor for T helper (Th) 1 and Th17 cells, controlling their

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Vale, Ana Margarida Gonçalves Candeias do. "Impact of Peripheral Inflammation on the Susceptibility to Neurodegenerative Diseases." Master's thesis, 2021. http://hdl.handle.net/10400.6/11501.

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Lipopolysaccharide (LPS) is an inflammatory agent widely used to induce peripheral inflammatory responses in animal models. When administered at low concentrations and over a short time interval, it has the ability to induce neuroprotection in animal models of Alzheimer’s Disease and stroke. This neuroprotective effect is due to the activation of the peripheral immune system and subsequently activation and induction of innate immune memory in microglial cells. Thus, the main objective of this work was to understand the effects of LPS and histamine, a biogenic amine also involved in peripheral

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Fang-YiKo and 柯芳宜. "Brain region-specific microglial activation in response to peripheral LPS-induced inflammation." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/27222561195714367804.

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碩士<br>國立成功大學<br>細胞生物及解剖學研究所<br>98<br>Microglia, one of three glial cell types in the central nervous system (CNS), play an important role as resident immunocompetent and phagocytic cells in the CNS in the event of injury and disease. Numerous studies indicated that peripheral inflammation may induce CNS inflammation and microglia activation. Activation of microglia is associated with cell transformation to phagocytes, capable of releasing potentially cytotoxic substances such as oxygen radicals, proteases, and proinflammatory cytokines. Recent studies indicated that CNS in?ammation and microgl

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Rosenkranz, Melissa A. "Reciprocal modulation of peripheral inflammation and affective neural circuitry in health and disease." 2008. http://www.library.wisc.edu/databases/connect/dissertations.html.

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Tian, Tin-Yi, and 田婷怡. "Peripheral inflammation induces cytokine expression in brain and increases the permeability of blood-brain barrier." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/07223055509356639351.

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碩士<br>國立成功大學<br>微生物暨免疫學研究所<br>87<br>英文摘要 The CNS (central nervous system) of mammal is considered to be an immunologically privileged site because it lacks lymphatic drainage, the brain is separated from the blood compartment by the blood-brain barrier (BBB). The brain also expresses FasL and TGFβ that can down-modulate the immune response. However, peripheral administration of lipopolysaccharide has been found to stimulate the hypothalamic- pituitary- adrenocortical axis to induce fever and influence behavior. This result showed that communication between peripheral immune syst

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Cuhlmann, S., W. Gsell, der Heiden K. Van, et al. "In vivo mapping of vascular inflammation using the translocator protein tracer 18F-FEDAA1106." 2014. http://hdl.handle.net/10454/10331.

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Yes<br>Non-invasive imaging methods are required to monitor the inflammatory content of atherosclerotic plaques. FEDAA1106 (N-(5-fluoro-2-phenoxyphenyl)-N-(2-(2-fluoroethoxy)-5- methoxybenzyl) acetamide) is a selective ligand for TSPO-18kDa (also known as peripheral benzodiazepine receptor), which is expressed by activated macrophages. We compared 18F- FEDAA1106 and 18F-FDG (a marker of glucose metabolism) for PET imaging of vascular inflammation. This was tested using a murine model where focal inflammation was induced in the carotid artery via placement of a constrictive cuff. Immunostainin

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Ho, Ying-Hao, and 何英豪. "Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/52580917089874888255.

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博士<br>國立中山大學<br>生物科學系研究所<br>103<br>Epilepsy is a common neurological disorder. Neuroinflammation is involved in the pathophysiology of epilepsy. Tissue oxidative stress is another confounding factor in epilepsy. While both neuroinflammation and brain oxidative stress are involved, relationship between these two factors in epileptogenesis, however, is not fully understood. In this study, I investigated the relationship and the underlying molecular mechanism. In aim 1, I established a rodent model of chronic neuroinflammation via peripheral inflammation induced by continuous infusion of E. coli

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KASSA, Roman Mehari. "The role of peripheral challenges and inflammation in motoneuron degeneration caused by nerve trauma and disease." Doctoral thesis, 2007. http://hdl.handle.net/11562/338054.

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Gli esperimenti presentati e discussi estesamente nelle sezioni 2,3 e 4 della Tesi si sono focalizzati sullo studio del motoneurone, un neurone con caratteristiche peculiari poiché il corpo cellulare risiede nel sistema nervoso centrale (SNC) ed ha come bersaglio il muscolo, al di fuori dell’SNC, che raggiunge tramite un lungo assone. Le caratteristiche peculiari del motoneurone, ed in particolare la sua relazione con il bersaglio periferico, sono state prese in considerazione in riferimento ad alterazioni degenerative che possono colpire tale cellula, quali la sclerosi laterale amiotrof

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Oruebor, Jennifer Nkem. "Peripheral blood biomarkers in youth with bipolar disorder: a systematic review." Thesis, 2019. https://hdl.handle.net/2144/36613.

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Bipolar disorder (BD) is a chronic, progressive illness characterized by fluctuations in mood. It is associated with psychosocial and cognitive impairment that can affect a person’s life at home, at work or school, and in interpersonal relationships. Children and adolescents diagnosed with BD experience similar functional impairments and risk for suicidal thoughts or actions compared to adults. Additionally, they are at an increased risk for poorer prognosis during adulthood given the negative outcomes associated with early illness onset, delayed treatment, misdiagnosis, and longer illness dur

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Chen, Ying-Ju, and 陳映儒. "Increased expression of a proton-sensing G-protein coupled receptor, TDAG8, in DRG neurons after peripheral inflammation." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/32750630763754454077.

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碩士<br>國立中央大學<br>生命科學研究所<br>94<br>High concentrations of hydrogen ions are usually found in local area surrounding the insulted tissues during several inflammatory responses. The tissue acidosis phenomenon is thought to be associated with inflammatory pain because the proton molecule can activate nociceptors (pain-related neurons) directly through proton-sensing ion channels. Several proton-sensing receptors expressed in dorsal root ganglia neurons. Some of them, such as vallinoid receptor1 and acid-sensing ion channel 3 are thought to be involved in inflammatory hyperalgesia. However, it is st

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Maseroli, Elisa. "Central and peripheral effects of Dihydrotestosterone (DHT) in females: a preclinical perspective." Doctoral thesis, 2020. http://hdl.handle.net/2158/1192669.

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Background. The underpinning mechanisms of the beneficial effects of androgens on female sexual behavior and on the integrity and functionality of genital tissues have not been elucidated. 1st study. Ovariectomized (OVX) Long-Evans rats were treated with oil (O) + O, 10 mcg Estradiol Benzoate (EB) + O, 10 mcg EB + 500 mcg Progesterone (P), O + 500 mcg Dihydrotestosterone (DHT) or 10 mcg EB + 500 mcg DHT (n = 12 per group). EB was administered 48 h, while P and DHT 4 h, prior to 4 sexual behavioral testing sessions in bisected unilevel pacing chambers. Appetitive behaviors (the frequencies of

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Kallur, Sailaja. "Investigation of Circadian Clock in Peripheral Tissues and Immune-Circadian Interaction in the Domestic Fowl, Gallus Domesticus." Thesis, 2012. http://hdl.handle.net/1969.1/148255.

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The circadian system provides living organisms a means to adapt their internal physiology to constantly changing environmental conditions that exists on our rotating planet, Earth. Clocks in peripheral tissues are referred to as peripheral which may participate in tissue-specific functions. The first step to investigating the circadian regulation in the peripheral tissues of avians was to examine for the presence of avian orthologs of core components of the molecular clock using Quantitative real time (qRTPCR) assays. We investigated the avian spleen for daily and circadian control of core cl

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He, Rong-Heng, and 何榕恒. "FK506-Binding Protein 51 Regulates GABAergic Neurotransmission-related Protein Expression in Peripheral Inflammation- versus Glucocorticoid- induced Anxiety Mouse Models." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/16676195364561600806.

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