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Journal articles on the topic 'Peripheral zone prostate cancer'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Gordeev, Vasiliy Vladimirovich, Regina Sergeevna Khakham, Aleksey Nikolaevich Evseev, et al. "Clinical significance of transperineal biopsy of the prostate transition zone in the diagnosis of prostate cancer." Spravočnik vrača obŝej praktiki (Journal of Family Medicine), no. 4 (March 23, 2022): 40–51. http://dx.doi.org/10.33920/med-10-2204-06.

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Urological diseases in Russia account for 10–12 % of the total morbidity of the population and are one of the reasons for the decline in the quality of life, disability and mortality. In the structure of urological pathology in men, inflammatory and neoplastic diseases of the prostate gland dominate, and therefore, their timely diagnosis is of particular relevance. Ultrasound-guided prostate biopsy is the standard and most important procedure for diagnosing prostate cancer. The aim of the study was to determine the clinical significance of transperineal biopsy of the prostate transition zone i

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Tran, Vuong Thuy, Shu-Ju Tu, and Jing-Ren Tseng. "68Ga-PSMA-11 PET/CT Features Extracted from Different Radiomic Zones Predict Response to Androgen Deprivation Therapy in Patients with Advanced Prostate Cancer." Cancers 14, no. 19 (2022): 4838. http://dx.doi.org/10.3390/cancers14194838.

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Purpose: Prediction of treatment response to androgen deprivation therapy (ADT) prior to treatment initiation remains difficult. This study was undertaken to investigate whether 68Ga-PSMA-11 PET/CT features extracted from different radiomic zones within the prostate gland might predict response to ADT in patients with advanced prostate cancer (PCa). Methods: A total of 35 patients with prostate adenocarcinoma underwent two 68Ga-PSMA-11 PET/CT scans—termed PET-1 and PET-2—before and after 3 months of ADT, respectively. The prostate was divided into three radiomic zones, with zone-1 being the me

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Karakoishin, K., Zh Zholdybay, A. Aynakulova, D. Toleshbaev, G. Muhit, and Ye Ayserbay. "DWI CAPACITY IN PROSTATE CANCER DIAGNOSING." Oncologia i radiologia Kazakhstana 68, no. 2 (2023): 36–42. http://dx.doi.org/10.52532/2521-6414-2023-2-68-36-42.

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Relevance: Prostate cancer is one of the leading causes of cancer deaths in men worldwide. Transrectal ultrasound-guided (TRUS) prostate biopsy is the most important diagnostic step, without which a definitive diagnosis cannot be made. Despite this, TRUS-guided prostate biopsy has a high rate of false negatives and is often accompanied by various clinical complications. Multiparametric MRI (mpMRI) is now widely used in routine urological and oncological practice. An element of mpMRI is diffusion-weighted imaging (DWI), which is successfully used in detecting and localizing clinically significa

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Karakoishin, K., Zh Zholdybay, A. Aynakulova, D. Toleshbaev, G. Muhit, and Ye Ayserbay. "DWI CAPACITY IN PROSTATE CANCER DIAGNOSING." Oncologia i radiologia Kazakhstana 68, no. 2 (2023): 36–42. http://dx.doi.org/10.52532/2663-4864-2023-2-68-36-42.

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Relevance: Prostate cancer is one of the leading causes of cancer deaths in men worldwide. Transrectal ultrasound-guided (TRUS) prostate biopsy is the most important diagnostic step, without which a definitive diagnosis cannot be made. Despite this, TRUS-guided prostate biopsy has a high rate of false negatives and is often accompanied by various clinical complications. Multiparametric MRI (mpMRI) is now widely used in routine urological and oncological practice. An element of mpMRI is diffusion-weighted imaging (DWI), which is successfully used in detecting and localizing clinically significa

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Choi, Moon-Hyung, Young-Joon Lee, Dongyeob Han, and Dong-Hyun Kim. "Quantitative Analysis of Prostate MRI: Correlation between Contrast-Enhanced Magnetic Resonance Fingerprinting and Dynamic Contrast-Enhanced MRI Parameters." Current Oncology 30, no. 12 (2023): 10299–310. http://dx.doi.org/10.3390/curroncol30120750.

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This research aimed to assess the relationship between contrast-enhanced (CE) magnetic resonance fingerprinting (MRF) values and dynamic contrast-enhanced (DCE) MRI parameters including (Ktrans, Kep, Ve, and iAUC). To evaluate the correlation between the MRF-derived values (T1 and T2 values, CE T1 and T2 values, T1 and T2 change) and DCE-MRI parameters and the differences in the parameters between prostate cancer and noncancer lesions in 68 patients, two radiologists independently drew regions-of-interest (ROIs) at the focal prostate lesions. Prostate cancer was identified in 75% (51/68) of pa

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Deb, Subrata, Mei Yieng Chin, Steven Pham, et al. "Steroidogenesis in Peripheral and Transition Zones of Human Prostate Cancer Tissue." International Journal of Molecular Sciences 22, no. 2 (2021): 487. http://dx.doi.org/10.3390/ijms22020487.

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The peripheral zone (PZ) and transition zone (TZ) represent about 70% of the human prostate gland with each zone having differential ability to develop prostate cancer. Androgens and their receptor are the primary driving cause of prostate cancer growth and eventually castration-resistant prostate cancer (CRPC). De novo steroidogenesis has been identified as a key mechanism that develops during CRPC. Currently, there is very limited information available on human prostate tissue steroidogenesis. The purpose of the present study was to investigate steroid metabolism in human prostate cancer tis

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Glazer, Daniel I., Matthew S. Davenport, Richard H. Cohan, et al. "Focal nodular prostatic peripheral zone enhancement on CT to predict clinically significant (Gleason 4+3 and higher) prostate cancer." Journal of Clinical Oncology 32, no. 4_suppl (2014): 173. http://dx.doi.org/10.1200/jco.2014.32.4_suppl.173.

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173 Background: CTs are insensitive for prostate cancer and inaccurate for local prostate cancer staging. However, enhancing peripheral zone nodules can be seen on a CT, and their significance is uncertain. The purpose of this study was to determine whether focal nodular enhancement within the prostatic peripheral zone on a CT is predictive of clinically significant prostate cancer. Methods: Institutional review board approval was obtained and informed consent waived for this Health Insurance Portability and Accountability Act-compliant retrospective study. Forty-three patients with high-grade

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Olko, Paweł, Gabriela Licak, Julia Tomkiewicz, et al. "The influence of genetic and environmental factors on the incidence of prostate cancer in men." Journal of Education, Health and Sport 13, no. 3 (2023): 271–82. http://dx.doi.org/10.12775/jehs.2023.13.03.036.

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Introduction The prostate gland is a small reproductive organ found in men. It consists of 3 zones: central, peripheral and transitional. The most common localization of prostate cancer in elderly men is the peripheral zone. Prostate cancer is one of the most common cancers in men. It ranks second in terms of incidence and fifth in terms of lethality among men worldwide. There are many factors that contribute to the development of prostate cancer in men. We can divide them into two large groups: genetic factors and environmental factors. These include, among others: older age, ethnicity / race

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Singla, Amit, Nerbadyswari Deep, Suprava Naik, Sudipta Mohakud, Prasant Nayak, and Mukund Sable. "Correlation of multiparametric MRI with histopathological grade of peripheral zone prostate carcinoma." Journal of Cancer Research and Therapeutics 19, Suppl 2 (2023): S569—S576. http://dx.doi.org/10.4103/jcrt.jcrt_280_22.

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ABSTRACTS Background: Prostatic cancer is the second most common malignant tumor in men. Preoperative grading of prostate cancer is important for its management. Our objective is to compare individual and combined detection rates of T2-weighted imaging (T2WI), diffusion weighted imaging (DWI), dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI), and magnetic resonance spectroscopy (MRS) for prostate cancer with histopathological diagnosis as its golden standard. Methods: Forty-four patients with positive digital rectal examination (DRE) findings and elevated prostate specific antige

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King, Martin T., Paul L. Nguyen, Ninjiin Boldbaatar, et al. "Long-term outcomes of magnetic resonance image-guided partial prostate brachytherapy for favorable-risk prostate cancer." Journal of Clinical Oncology 36, no. 6_suppl (2018): 138. http://dx.doi.org/10.1200/jco.2018.36.6_suppl.138.

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138 Background: To report long-term outcomes of magnetic resonance image-guided partial prostate brachytherapy of the peripheral zone. Methods: We conducted an institutional-board approved retrospective review of all men who underwent 0.5 Tesla GE Signa SP MRI-guided partial prostate brachytherapy to the peripheral zone. We estimated actuarial rates of biochemical progression (nadir +2 definition), as well as cumulative incidences of biopsy proven local recurrence, distant metastasis, and prostate cancer specific mortality. Fine and Gray’s competing risk regression was utilized in order to eva

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Lazarovich, Alon, Tomer Drori, Dorit E. Zilberman, Orith Portnoy, Zohar A. Dotan, and Barak Rosenzweig. "The Added Value of Systematic Sampling in In-Bore Magnetic Resonance Imaging-Guided Prostate Biopsy." Journal of Personalized Medicine 13, no. 9 (2023): 1373. http://dx.doi.org/10.3390/jpm13091373.

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We sought to quantify the additive value of systematic biopsy (SB) using in-bore magnetic resonance (MR)-guided prostate biopsy (IBMRGpB) by retrospectively reviewing the records of 189 patients who underwent IBMRGpB for suspected prostate cancer or as part of the surveillance protocol for previously diagnosed prostate cancer. The endpoints included clinically significant and non-clinically significant cancer diagnosis. SB detected clinically significant disease in 67 (35.5%) patients. Five (2.65%) patients whose targeted biopsies indicated benign or non-clinically significant disease had clin

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Sahu, Mahua, Nevin Wijesekera, and John F. Donohue. "Anterior prostate cancer: Current perspectives and diagnostic dilemmas." Journal of Clinical Urology 10, no. 1 (2016): 49–55. http://dx.doi.org/10.1177/2051415816655724.

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Anterior zone (transition zone and anterior horn of peripheral zone) tumours represent 20–30% of all prostate cancers. Traditional transrectal prostate biopsies fail to sample this area of the prostate gland adequately, thereby underestimating the true extent of anterior zone cancers. This article outlines the behaviour and significance of this entity and discusses investigations that are currently available which may aid in their detection. The implementation of transperineal template-guided prostate biopsies will allow optimal sampling of the anterior zone whilst advances in the field of mag

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Colombo, Piergiuseppe, Carlo Patriarca, Rosa Maria Alfano, et al. "Molecular disorders in transitionalvs. peripheral zone prostate adenocarcinoma." International Journal of Cancer 94, no. 3 (2001): 383–89. http://dx.doi.org/10.1002/ijc.1485.

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14

Lee, J. Joy, I.-Chun Thomas, Rosalie Nolley, Michelle Ferrari, James D. Brooks, and John T. Leppert. "Biologic differences between peripheral and transition zone prostate cancer." Prostate 75, no. 2 (2014): 183–90. http://dx.doi.org/10.1002/pros.22903.

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15

Winata, Herry Sofyan, and Putu Patriawan. "Evaluation of prostate cancer on MRI with PI-RADS 2.1: A serial case." Intisari Sains Medis 15, no. 1 (2024): 501–5. http://dx.doi.org/10.15562/ism.v15i1.1988.

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Background: Cancer that affects men's prostate glands is called prostate cancer. Magnetic resonance imaging (MRI) is a much more recommended method of examination because it evaluates the prostate in detail. MRI with Prostate Imaging–Reporting and Data System (PI-RADS) 2.1 can be used as a reporting system for prostate expertise and looking at the character of a lesion. This case series aims to present the prostate cancer cases on MRI with PI-RADS 2.1. Case report: First case, a 61-year-old male patient came with complaints of bloody urine and difficulty urinating. MRI results showed a well-de

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Leech, Michelle, John Gaffney, and Laure Marignol. "Improving non-invasive detection of prostate cancer using diffusion-weighted MRI." Advances in Modern Oncology Research 2, no. 6 (2016): 309. http://dx.doi.org/10.18282/amor.v2.i6.152.

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Prostate cancer represents 11% of all cancers in the European Union and 9% of all cancer deaths. Standard MRI for prostate cancer includes high-resolution T2-weighted images, which allow for the assessment of the prostate and the tumour, as tumours arising from the peripheral zone appear dark compared to the expected normally bright peripheral gland tissue. Over the past number of years, the application of diffusion-weighted MRI (DW-MRI) has progressed to include both diagnostic and prognostic roles in oncology. DW-MRI images should be analysed together with the T2-weighted images and the corr

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Hellstern, Marius, Carlos Martinez, Christopher Wallenhorst, et al. "Optimal length and temporal resolution of dynamic contrast-enhanced MR imaging for the differentiation between prostate cancer and normal peripheral zone tissue." PLOS ONE 18, no. 6 (2023): e0287651. http://dx.doi.org/10.1371/journal.pone.0287651.

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The value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in the detection of prostate cancer is controversial. There are currently insufficient peer reviewed published data or expert consensus to support routine adoption of DCE-MRI for clinical use. Thus, the objective of this study was to explore the optimal temporal resolution and measurement length for DCE-MRI to differentiate cancerous from normal prostate tissue of the peripheral zone of the prostate by non-parametric MRI analysis and to compare with a quantitative MRI analysis. Predictors of interest were onset time, r

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Druskin, Sasha C., Jeffrey J. Tosoian, Allen Young, et al. "The necessity of dynamic contrast enhanced imaging for prostate MRI: A study of pathologic outcomes on prostate biopsy." Journal of Clinical Oncology 35, no. 6_suppl (2017): 52. http://dx.doi.org/10.1200/jco.2017.35.6_suppl.52.

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52 Background: PIRADS version 2 guidelines for the interpretation of multi-parametric prostate MRI (mpMRI) stipulates that dynamic contrast-enhanced (DCE) imaging be used to classify diffusion weighted imaging (DWI) score 3 peripheral zone lesions into PIRADS-3 (DCE-) or PIRADS-4 (DCE+) lesions. Despite this, it is unknown if DCE based classification separates lesions into clinically meaningful pathologic groups. Because use of contrast adds time, risk (though modest), and cost to mpMRI, we sought to examine whether use of DCE indeed improves detection of clinically-significant cancer. Methods

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Sellers, Jake, Rachel G. Wagstaff, Naseem Helo, and Werner T. W. de Riese. "Quantitative measurements of prostatic zones by MRI and their dependence on prostate size: possible clinical implications in prostate cancer." Therapeutic Advances in Urology 13 (January 2021): 175628722110008. http://dx.doi.org/10.1177/17562872211000852.

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Aim: Many studies support an inverse relationship between benign prostate hypertrophy (BPH) size and incidence of prostate cancer (PCa), but the causal link between these conditions is poorly understood. Recent studies suggest that a growing transition zone (TZ) in the prostate may induce pressure on the outer peripheral zone (PZ), leading to atrophy of the glandular tissue where PCa often originates, providing a possible explanation for this interaction. To further investigate this phenomenon, our pilot study uses magnetic resonance imaging (MRI) to examine quantitative zonal changes in a con

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Onay, Aslihan, Gokhan Ertas, Metin Vural, et al. "Evaluation of Peripheral Zone Prostate Cancer Aggressiveness Using the Ratio of Diffusion Tensor Imaging Measures." Contrast Media & Molecular Imaging 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/5678350.

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Purpose. To evaluate the aggressiveness of peripheral zone prostate cancer by correlating the Gleason score (GS) with the ratio of the diffusion tensor imaging (DTI) measures. Materials and Methods. Forty-two peripheral zone prostate tumors were imaged using DTI. Regions of interest focusing on the center of tumor foci and noncancerous tissue were used to extract statistical measures of mean diffusivity (MD) and fractional anisotroy (FA). Measure ratio was calculated by dividing tumor measure by noncancerous tissue measure. Results. Strong correlations are observable between GS and MD measures

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Liu, Jiazhou, Shihang Pan, Liang Dong, et al. "The Diagnostic Value of PI-RADS v2.1 in Patients with a History of Transurethral Resection of the Prostate (TURP)." Current Oncology 29, no. 9 (2022): 6373–82. http://dx.doi.org/10.3390/curroncol29090502.

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To explore the diagnostic value of the Prostate Imaging–Reporting and Data System version 2.1 (PI-RADS v2.1) for clinically significant prostate cancer (CSPCa) in patients with a history of transurethral resection of the prostate (TURP), we conducted a retrospective study of 102 patients who underwent systematic prostate biopsies with TURP history. ROC analyses and logistic regression analyses were performed to demonstrate the diagnostic value of PI-RADS v2.1 and other clinical characteristics, including PSA and free/total PSA (F/T PSA). Of 102 patients, 43 were diagnosed with CSPCa. In ROC an

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Lai, Chih-Ching, Hsin-Kai Wang, Fu-Nien Wang, et al. "Autosegmentation of Prostate Zones and Cancer Regions from Biparametric Magnetic Resonance Images by Using Deep-Learning-Based Neural Networks." Sensors 21, no. 8 (2021): 2709. http://dx.doi.org/10.3390/s21082709.

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The accuracy in diagnosing prostate cancer (PCa) has increased with the development of multiparametric magnetic resonance imaging (mpMRI). Biparametric magnetic resonance imaging (bpMRI) was found to have a diagnostic accuracy comparable to mpMRI in detecting PCa. However, prostate MRI assessment relies on human experts and specialized training with considerable inter-reader variability. Deep learning may be a more robust approach for prostate MRI assessment. Here we present a method for autosegmenting the prostate zone and cancer region by using SegNet, a deep convolution neural network (DCNN

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Huang, Guan, Gerald Lebovic, and Paraskevi A. Vlachou. "Diagnostic Value of CT in Detecting Peripheral Zone Prostate Cancer." American Journal of Roentgenology 213, no. 4 (2019): 831–35. http://dx.doi.org/10.2214/ajr.18.21013.

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Ohori, Makoto, Toyoaki Uchida, Takefumi Sato, et al. "Is there really a difference between peripheral zone and transition zone prostate cancer?" Japanese Journal of Urology 86, no. 3 (1995): 434. http://dx.doi.org/10.5980/jpnjurol.86.434_2.

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Tsurusaki, Toshifumi, Daiyu Aoki, Hiroshi Kanetake та ін. "Zone-Dependent Expression of Estrogen Receptors α and β in Human Benign Prostatic Hyperplasia". Journal of Clinical Endocrinology & Metabolism 88, № 3 (2003): 1333–40. http://dx.doi.org/10.1210/jc.2002-021015.

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Estrogen, which acts through estrogen receptors (ERs) α and β, has been implicated in the pathogenesis of benign and malignant human prostatic tumors, i.e. benign prostatic hyperplasia and prostate cancer, thought to originate from different zones of the prostate [the transition zone (TZ) and peripheral zone (PZ), respectively]. Here, we examined the cellular distribution of ERα and ERβ in human normal and hyperplastic prostate tissues, using in situ hybridization and immunohistochemistry. ERα expression was restricted to stromal cells of PZ. In contrast, ERβ was expressed in the stromal cells

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Zhang, Yan, Jie Tang, Yan-mi Li, et al. "The contribution of strain patterns in characterization of prostate peripheral zone lesions at transrectal ultrasonography." Acta Radiologica 53, no. 1 (2012): 119–26. http://dx.doi.org/10.1258/ar.2011.110504.

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Background Elasticity is an important characteristic of tissue. During an elastography examination, various strain images of lesions are observed, and a suitable classification of strain patterns (SP) may provide vital diagnostic information about lesions. Numerous studies have shown that ultrasound elastography can improve the detection of prostate cancer, but the diagnostic value of SP classification has not yet been fully evaluated. Purpose To investigate the contribution of SP on the characterization of prostate peripheral zone lesions by transrectal real-time tissue elastography (TRTE) in

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Aliukonis, Paulius, Tadas Letauta, Rūta Briedienė, Ieva Naruševičiūtė, and Simona Letautienė. "The role of different PI-RADS versions in prostate multiparametric magnetic resonance tomography assessment." Acta medica Lituanica 24, no. 1 (2017): 44–50. http://dx.doi.org/10.6001/actamedica.v24i1.3462.

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Background. Standardised Prostate Imaging Reporting and Data System (PI-RADS) guidelines for the assessment of prostate alterations were designed for the assessment of prostate pathology. Published by the ESUR in 2012, PI-RADS v1 was based on the total score of different MRI sequences with subsequent calculation. PI-RADS v2 was published by the American College of Radiology in 2015 and featured different assessment criteria for prostate peripheral and transitory zones. Aim. To assess the correlations of PI-RADS v1 and PI-RADS v2 with Gleason score values and to define their predictive values o

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Kovtun, Konstantin, Tobias Penzkofer, Neha Agrawal, et al. "Location of local recurrence after MRI-guided partial prostate brachytherapy targeting only the peripheral zone: Implications for focal therapy." Journal of Clinical Oncology 31, no. 6_suppl (2013): 149. http://dx.doi.org/10.1200/jco.2013.31.6_suppl.149.

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149 Background: Prostate cancer local recurrences usually occur at the same site as the dominant primary tumor in patients treated with radiation therapy to the whole gland. We characterized location of local recurrences in patients who were treated with MRI Guided Partial Brachytherapy in which only the peripheral zone was targeted. Methods: We retrospectively reviewed ten patients with initial cT1c, Gleason score 3+4 or less prostate cancer who developed biopsy proven local recurrences and had available imaging after MRI Guided Partial Brachytherapy targeting the peripheral zone from 1998 to

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Lee, Hakmin, Sung Il Hwang, Hak Jong Lee, Seok-Soo Byun, Sang Eun Lee, and Sung Kyu Hong. "Diagnostic performance of diffusion-weighted imaging for prostate cancer: Peripheral zone versus transition zone." PLOS ONE 13, no. 6 (2018): e0199636. http://dx.doi.org/10.1371/journal.pone.0199636.

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Nakonechnyi, Yosyf, Yulian Mytsyk, and Andriy Borzhievskyi. "PCA3 performance in localized prostate cancer." World Journal of Medical Innovations 4, no. 1 (2024): 42–47. https://doi.org/10.5281/zenodo.14176522.

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PCa incidence and mortality is rising. It is the fifth most common cause of mortality globally, and it is the most frequently diagnosed cancer in Europe. The PCa screening, diagnosing and treatment keeps being extremely actual. Much more popularity in PCa screening and diagnosing gains biomarkers. In our previous results we described the influence of the tumor zone origin (TZO) and tumor growth dominant pattern (TGDP) on PCA3 urine levels. In this work we try to evaluate performance of the PCA3 urine levels in identifying clinical significant PCa according to the postoperative ISUP class. The

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Gothi, Rajesh. "Unenhanced CT Can Be Enough to Detect Peripheral Zone Prostate Cancer." American Journal of Roentgenology 214, no. 5 (2020): W84. http://dx.doi.org/10.2214/ajr.19.22390.

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Siegel, Cary. "Re: Diagnostic Value of CT in Detecting Peripheral Zone Prostate Cancer." Journal of Urology 203, no. 5 (2020): 861. http://dx.doi.org/10.1097/ju.0000000000000766.

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Nelson, Chris R., Jessica Ekberg, and Kent Fridell. "Prostate Cancer Detection in Screening Using Magnetic Resonance Imaging and Artificial Intelligence." Open Artificial Intelligence Journal 6, no. 1 (2020): 1–11. http://dx.doi.org/10.2174/1874061802006010001.

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Background: Prostate cancer is a leading cause of death among men who do not participate in a screening programme. MRI forms a possible alternative for prostate analysis of a higher level of sensitivity than the PSA test or biopsy. Magnetic resonance is a non-invasive method and magnetic resonance tomography produces a large amount of data. If a screening programme were implemented, a dramatic increase in radiologist workload and patient waiting time will follow. Computer Aided-Diagnose (CAD) could assist radiologists to decrease reading times and cost, and increase diagnostic effectiveness. C

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Chiam, K., S. Jindal, N. Ryan, et al. "166. MATERNAL OBESITY IS ASSOCIATED WITH AN INCREASED INCIDENCE OF PROSTATE ABNORMALITIES IN ADULT RAT OFFSPRING." Reproduction, Fertility and Development 21, no. 9 (2009): 84. http://dx.doi.org/10.1071/srb09abs166.

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The World Health Organization has stated that 75% of adults worldwide are overweight, and in Australia nearly 25% of men are obese. Obesity is associated with an increased risk of cardiovascular disease, type 2 diabetes and cancer, with 30 to 40% of the latter possibly preventable by maintaining a healthy weight (The International Association for the Study of Obesity). Prostate cancer is the most commonly diagnosed cancer in men and there is increasing evidence that obesity increases the risk of prostate cancer mortality. High birth weight, an indication of excess nutrition during foetal devel

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Cindil, Emetullah, Yusuf Oner, Halit Nahit Sendur, et al. "The Utility of Diffusion-Weighted Imaging and Perfusion Magnetic Resonance Imaging Parameters for Detecting Clinically Significant Prostate Cancer." Canadian Association of Radiologists Journal 70, no. 4 (2019): 441–51. http://dx.doi.org/10.1016/j.carj.2019.07.005.

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Introduction To establish the diagnostic performance of the parameters obtained from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging at 3T in discriminating between non-clinically significant prostate cancers (ncsPCa, Gleason score [GS] < 7) and clinically significant prostate cancers (csPCa, GS ≥ 7) in the peripheral zone. Materials and Methods Twenty-six male patients with peripheral zone prostate cancer (PCa) who had undergone 3T multiparametric magnetic resonance imaging (MRI) scan prior to biopsy were included in the study and evaluated ret

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Szollosi, Attila, Orsolya Martha, Lorand Denes, Arpad Oliver Vida, Adrian Maier, and Zoltan Pavai. "Role of transurethral resection of the prostate in the management of prostate cancer." Acta Medica Marisiensis 62, no. 2 (2016): 205–8. http://dx.doi.org/10.1515/amma-2016-0008.

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AbstractIntroduction: Prostate cancer is the second most diagnosed cancer in men, after lung cancer. The gold standard procedure in prostate cancer (PCa) diagnosis is the ultrasound guided prostate biopsy. Transurethral resection of the prostate (TURP) used in solving the bladder outlet obstruction, can have a role in detection of PCa. The aim of this retrospective study is to examine the role of transurethral resection of the prostate in the diagnosis and therapy of prostate cancer.Materials and methods: At the Urology Clinic of Targu Mures we performed a total of 474 TURP over a two year per

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Raphael, John E., and Onyeanunam N. Ekeke. "T1a/T1b transitional zone prostate cancer detection rates in patients who had TURP for clinically diagnosed benign prostatic enlargement in Southern Nigeria." European Journal of Health Sciences 7, no. 2 (2022): 1–7. http://dx.doi.org/10.47672/ejhs.995.

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Background: Transurethral resection of the prostate (TURP) removes the obstructing adenoma that grows from the transitional zone of the prostate. Resected chips are routinely sent for histologic examination. Incidental findings of prostate cancer in the TURP specimen for the clinically diagnosed benign disease may occur. The American Joint Committee on Cancer (AJCC) TNM staging of prostate cancer allocates T1a if <5% of the resected chips are malignant and T1b if >5% are malignant. Aim: To determine the frequency of incidental prostate cancer rate in TURP specimens of patients who

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Xu, Wenjuan, HaiYan Cao, Fang Du, Ling He, FangLian Jiang, and ChunHong Hu. "Magnetic Resonance Image Compilation Was Used in Conjunction with Prostate PI-RADS v2.1 Score Has Diagnostic Relevance for Benign and Malignant Prostate Lesions." Computational and Mathematical Methods in Medicine 2022 (August 29, 2022): 1–10. http://dx.doi.org/10.1155/2022/3613540.

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Objective. To assess the diagnostic usefulness of magic in conjunction with PI-RADS v2.1 for prostate cancer malignant foci. Methods. A total of 202 lesions (97 transitional zone lesions and 105 peripheral zone lesions) from 198 people were investigated retrospectively using traditional MRI and magic images. Each lesion has a unique pathological consequence. Lesions T1, T2, and PD values were employed as magic observation markers. The locations of the lesions were aggregated, and the paired t -test and receiver operating characteristic curve (ROC) were employed to find the indices with statist

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Manenti, Guglielmo, Marco Nezzo, Fabrizio Chegai, Erald Vasili, Elena Bonanno, and Giovanni Simonetti. "DWI of Prostate Cancer: Optimalb-Value in Clinical Practice." Prostate Cancer 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/868269.

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Aim. To compare the diagnostic performance of diffusion weighted imaging (DWI) usingb-values of 1000 s/mm2and 2000 s/mm2at 3 Tesla (T) for the evaluation of clinically significant prostate cancer.Matherials and Methods. Seventy-eight prostate cancer patients underwent a 3T MRI scan followed by radical prostatectomy. DWI was performed usingb-values of 0, 1000, and 2000 s/mm2and qualitatively analysed by two radiologists. ADC maps were obtained atb-values of 1000 and 2000 s/mm2and quantitatively analyzed in consensus.Results. For diagnosis of 78 prostate cancers the accuracy of DWI for the young

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Fascelli, Michele, Thomas P. Frye, Arvin Koruthu George, et al. "MRI/US fusion-guided biopsy to detect clinically significant prostate cancer in the central gland correlating with index lesion." Journal of Clinical Oncology 33, no. 7_suppl (2015): 44. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.44.

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44 Background: Central gland (CG) prostate cancers (CaP) are reported with lesser incidence and smaller tumor volume compared to the peripheral zone (PZ). Index tumor lesions defined by highest grade may be missed when in the CG. MRI/US fusion-guided biopsy allows targeting of lesions, potentially identifying cancer outside the traditional TRUS biopsy template. Methods: Retrospective review of 1,003 patients who underwent multiparametric MRI (mpMRI) found 2,119 suspicious lesions. Targets were biopsied and stratified by zonal distribution, CG or PZ. Cancer detection rates (CDR) were tabulated

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Zattoni, F. "Benign Prostatic Hypertrophy, Prostatic Cancer and Preneoplastic Lesions." Urologia Journal 59, no. 1 (1992): 58–60. http://dx.doi.org/10.1177/039156039205900113.

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Quite recently two dysplastic lesions have been found in prostatic tissue: atypical hyperplasia (AH), found in the periurethral zone, and prostatic intraepithelial neoplasia (PIN), present in the peripheral zone of the prostate. These lesions are likely to be considered as preneoplastic lesions. Theoretically they could be interpreted as the link between normal prostatic tissue and the cancer. It has also been suggested that BPH possibly contributes to the carcinogenetic process due to the demonstrated modifications occuring in the hyperplastic gland.

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Sun, Haoran, Lixia Wang, Timothy Daskivich, et al. "Retrospectively Quantified T2 Improves Detection of Clinically Significant Peripheral Zone Prostate Cancer." Cancers 17, no. 3 (2025): 381. https://doi.org/10.3390/cancers17030381.

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Background: Multiparametric MRI (mpMRI) as a non-invasive imaging tool is important in prostate cancer (PCa) detection and localization. Combined with radiomics analysis, features extracted from mpMRI have been utilized to predict PCa aggressiveness. T2 mapping provides quantitative information in PCa diagnoses but is not routinely available in clinical practice. Previous work from our group developed a deep learning-based method to estimate T2 maps from clinically acquired T1- and T2-weighted images. This study aims to evaluate the added value of the estimated T2 map by combining it with conv

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Di Silverio, F., G. D'Eramo, A. Sciarra, et al. "Growth factors in benign prostatic hyperplasia (BPH) and prostate carcinoma." Urologia Journal 62, no. 4 (1995): 509–17. http://dx.doi.org/10.1177/039156039506200401.

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It has been stated that, although steroid hormones are a necessary prerequisiste for prostate cell proliferation, cell division is not an inevitable consequence of the presence of hormones. The possibility that diffusible trophic factors play an important role in the normal and pathologic regulatory process within the prostate, offers a new and exciting research initiative. In order to better clarify the relationships between Epidermal growth factor (EGF), its receptor (EGFr) and steroid receptors at target tissue levels, we have demonstrated a statistically significant linear correlation betw

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Anwar, Shayan Sirat Maheen, Zahid Anwar Khan, Rana Shoaib Hamid, et al. "Assessment of Apparent Diffusion Coefficient Values as Predictor of Aggressiveness in Peripheral Zone Prostate Cancer: Comparison with Gleason Score." ISRN Radiology 2014 (February 9, 2014): 1–7. http://dx.doi.org/10.1155/2014/263417.

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Purpose. To determine association between apparent diffusion coefficient value on diffusion-weighted imaging and Gleason score in patients with prostate cancer. Methods. This retrospective case series was conducted at Radiology Department of Aga Khan University between June 2009 and June 2011. 28 patients with biopsy-proven prostate cancer were included who underwent ultrasound guided sextant prostate biopsy and MRI. MRI images were analyzed on diagnostic console and regions of interest were drawn. Data were entered and analyzed on SPSS 20.0. ADC values were compared with Gleason score using o

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Selnæs, Kirsten M., Arend Heerschap, Line R. Jensen, et al. "Peripheral Zone Prostate Cancer Localization by Multiparametric Magnetic Resonance at 3 T." Investigative Radiology 47, no. 11 (2012): 624–33. http://dx.doi.org/10.1097/rli.0b013e318263f0fd.

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Bansal, Aruna, Darrell K. Murray, James T. Wu, Robert A. Stephenson, Richard G. Middleton, and A. Wayne Meikle. "Heritability of Prostate-Specific Antigen and Relationship with Zonal Prostate Volumes in Aging Twins*." Journal of Clinical Endocrinology & Metabolism 85, no. 3 (2000): 1272–76. http://dx.doi.org/10.1210/jcem.85.3.6399.

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Abstract Both benign prostatic hyperplasia and prostate-specific antigen (PSA) have been shown to increase with age and with prostate volume in men, but the influence of heredity on these relationships is not completely understood. This study has two aims: 1) to investigate the inter-relationships of age, PSA, and various zonal measurements in the prostate; and 2) to assess the impact of heritable influences on total PSA. Eighty-four monozygotic twin pairs and 83 dizygotic twin pairs were studied, and serum total PSA, free PSA, and PSA-∝1-antichymotrypsin were measured. Their prostate volumes

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Couture, Anne, Mounsif Azizi, Daniel Taussky, and Michael McCormack. "Case: Incidental 18F-fluorodeoxyglucose-positron emission tomography/computed tomography prostate uptake: How should these patients be managed?" Canadian Urological Association Journal 11, no. 7 (2017): E318–20. http://dx.doi.org/10.5489/cuaj.4426.

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18F-fluorodeoxyglucose-positron emission tomography/ computed tomography (18F-FDG PET/CT) is a widely used diagnostic tool for whole-body imaging, and incidental prostatic uptake occurs in approximately 1% of patients undergoing the exam. Is 18F-FDG PET/CT a reliable screening tool for prostate cancer? Should these patients undergo transrectal ultrasound (TRUS)-guided prostate biopsies? Studies have indicated that 18F-FDG PET/CT has a low positive predictive value for prostate cancer and is not recommended for screening;1 however, other studies suggest that when a discrete focal 18F-FDG uptake

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Nahar, Bruno, Nachiketh Soodana-Prakash, Nicola Pavan, et al. "Cancer detection between peripheral zone and transitional zone targeted biopsies: Preliminary results from a prospective cohort of men undergoing MRI-US fusion biopsy." Journal of Clinical Oncology 34, no. 2_suppl (2016): 56. http://dx.doi.org/10.1200/jco.2016.34.2_suppl.56.

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56 Background: Multiparametric MRI has emerged as a popular imaging modality to localize prostate cancer. Nevertheless, interpretation of MRI is subjective, with concerns for false positives, particularly in the transitional zone (TZ), where hyperplastic changes may be confused for suspicion of cancer. We analyzed a prospective cohort of men undergoing MRI-US fusion biopsy and compared cancer detection rate between lesions seen in the peripheral zone (PZ) and the TZ. Methods: 133 men with elevated PSA or positive DRE underwent MRI-US fusion biopsy with average of 2 cores taken per target for t

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Nagarajan, Rajakumar, Daniel JA Margolis, Steven S. Raman, et al. "Mr Spectroscopic Imaging of Peripheral Zone in Prostate Cancer Using a 3t Mri Scanner: Endorectal versus External Phased Array Coils." Magnetic Resonance Insights 6 (January 2013): MRI.S10861. http://dx.doi.org/10.4137/mri.s10861.

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Magnetic resonance spectroscopic imaging (MRSI) detects alterations in major prostate metabolites, such as citrate (Cit), creatine (Cr), and choline (Ch). We evaluated the sensitivity and accuracy of three-dimensional MRSI of prostate using an endorectal compared to an external phased array “receive” coil on a 3T MRI scanner. Eighteen patients with prostate cancer (PCa) who underwent endorectal MR imaging and proton (1H) MRSI were included in this study. Immediately after the endorectal MRSI scan, the PCa patients were scanned with the external phased array coil. The endorectal coil-detected m

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Mian, Badar M. "Prostate Biopsy Strategies: Current State of the Art." Journal of the National Comprehensive Cancer Network 2, no. 3 (2004): 213–22. http://dx.doi.org/10.6004/jnccn.2004.0020.

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Prostate-specific antigen testing and prostate biopsy have revolutionized our ability to detect prostate cancer at an early stage. The transrectal ultrasound-guided biopsy procedure has undergone a number of modifications over the past 10 years to meet our goal of early detection of cancer at a curable stage. Biopsy schemes have evolved from lesion-directed biopsies to systematic mapping of the peripheral zone of the prostate, which harbors almost all of the significant tumor foci. An increase in the number of biopsy cores from 6 to 10 (or 12) has resulted in a significant improvement in the d

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