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Journal articles on the topic 'Periprosthetic joint infections'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Lima, Ana Lucia L., Priscila R. Oliveira, Vladimir C. Carvalho, Eduardo S. Saconi, Henrique B. Cabrita, and Marcelo B. Rodrigues. "Periprosthetic Joint Infections." Interdisciplinary Perspectives on Infectious Diseases 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/542796.

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Implantation of joint prostheses is becoming increasingly common, especially for the hip and knee. Infection is considered to be the most devastating of prosthesis-related complications, leading to prolonged hospitalization, repeated surgical intervention, and even definitive loss of the implant. The main risk factors to periprosthetic joint infections (PJIs) are advanced age, malnutrition, obesity, diabetes mellitus, HIV infection at an advanced stage, presence of distant infectious foci, and antecedents of arthroscopy or infection in previous arthroplasty. Joint prostheses can become infecte

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Sigmund, Irene K., Markus Luger, Reinhard Windhager, and Martin A. McNally. "Diagnosing periprosthetic joint infections." Bone & Joint Research 11, no. 9 (2022): 608–18. http://dx.doi.org/10.1302/2046-3758.119.bjr-2022-0078.r1.

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Aims This study evaluated the definitions developed by the European Bone and Joint Infection Society (EBJIS) 2021, the International Consensus Meeting (ICM) 2018, and the Infectious Diseases Society of America (IDSA) 2013, for the diagnosis of periprosthetic joint infection (PJI). Methods In this single-centre, retrospective analysis of prospectively collected data, patients with an indicated revision surgery after a total hip or knee arthroplasty were included between 2015 and 2020. A standardized diagnostic workup was performed, identifying the components of the EBJIS, ICM, and IDSA criteria

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Saccente, Michael. "Periprosthetic Joint Infections." Infectious Diseases in Clinical Practice 7, no. 9 (1998): 431–41. http://dx.doi.org/10.1097/00019048-199812000-00003.

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Fedorov, E. A., S. O. Kretien, A. G. Samokhin, N. V. Tikunova, A. A. Korytkin, and V. V. Pavlov. "Short-term results of treatment of staphylococcal periprosthetic hip joint infection with combined antibiotics and bacteriophages treatment." Acta Biomedica Scientifica 6, no. 4 (2021): 50–63. http://dx.doi.org/10.29413/abs.2021-6.4.5.

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Infectious complications after primary implantation of the hip joint are 0.5–3 %, and in the case of re-endoprosthetics, the risk of periprosthetic infection can reach 30 %. Also, we should not forget about the high percentage (16–20 %) of recurrence of periprosthetic infection of the hip joint, which leads to an unsatisfactory result of treatment up to amputation of a limb or even death of the patient. The reasons for the recurrence of the infectious process can be antibiotic resistance and antibiotic tolerance of microorganisms, as well as the ability of microorganisms to form biofilms on im

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Bozhkova, Svetlana A., Rashid M. Tikhilov, and Vasily A. Artyukh. "Periprosthetic Joint Infection as a Socio-Economic Problem of Modern Orthopedics." Annals of the Russian academy of medical sciences 78, no. 6 (2024): 601–8. http://dx.doi.org/10.15690/vramn8370.

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Periprosthetic joint infection is the main social and economic problem of modern orthopedics with a recurrence rate of chronic forms of up to 23.2–31.5%. The aim of this review is to inform various specialties doctors about the features of pathogenesis, etiology and treatment of periprosthetic joint infection, which significantly differ it from of other surgical site infections. The severity of infectious complications is due to the suppression of the patient’s immune system and microbial biofilms. Surgical treatment of periprosthetic joint infection involves debridement with preservation or r

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Tan, Timothy L., Michael M. Kheir, Dean D. Tan, and Javad Parvizi. "Polymicrobial Periprosthetic Joint Infections." Journal of Bone and Joint Surgery 98, no. 24 (2016): 2082–88. http://dx.doi.org/10.2106/jbjs.15.01450.

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Thiesen, Darius M., Seval Mumin-Gündüz, Thorsten Gehrke, et al. "Synchronous Periprosthetic Joint Infections." Journal of Bone and Joint Surgery 102, no. 4 (2020): 283–91. http://dx.doi.org/10.2106/jbjs.19.00835.

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Cierny,, G., and D. DiPasquale. "Periprosthetic Total Joint Infections." Clinical Orthopaedics and Related Research 403 (October 2002): 23–28. http://dx.doi.org/10.1097/00003086-200210000-00005.

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Podhorecki, Adam, Artur Gądek, and Henryk Liszka. "Prevention of periprosthetic knee joint infections. Experience based on 590 patients treated before and after the introduction of a proprietary protocol." Chirurgia Narządów Ruchu i Ortopedia Polska 89, no. 2 (2024): 58–66. http://dx.doi.org/10.31139/chnriop.2024.89.2.2.

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Introduction. Total knee arthroplasty is a widely performed procedure in orthopedics. One of its complications is periprosthetic joint infection. Efforts should be made to reduce their frequency by implementing appropriate preventive protocols. Objective. To assess the incidence of infectious complications and their association with comorbidities and to retrospectively evaluate the effectiveness of a polymodal protocol for preventing periprosthetic infections implemented in 2015. Further the paper aims to evaluate the spectrum of pathogens responsible for these complications. Materials and met

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Sangaletti, Rudy, Luigi Zanna, Mustafa Akkaya, et al. "Periprosthetic joint infection in patients with multiple arthroplasties." Bone & Joint Journal 105-B, no. 3 (2023): 294–300. http://dx.doi.org/10.1302/0301-620x.105b3.bjj-2022-0800.r1.

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AimsDespite numerous studies focusing on periprosthetic joint infections (PJIs), there are no robust data on the risk factors and timing of metachronous infections. Metachronous PJIs are PJIs that can arise in the same or other artificial joints after a period of time, in patients who have previously had PJI.MethodsBetween January 2010 and December 2018, 661 patients with multiple joint prostheses in situ were treated for PJI at our institution. Of these, 73 patients (11%) developed a metachronous PJI (periprosthetic infection in patients who have previously had PJI in another joint, after a l

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Tsitko, Hanna, Paulina Dudzińska, Małgorzata Milanowska, Aleksandra Grudzińska, and Dominika Jarosz. "The diagnosis of periprosthetic joint infection after the arthroplasty of knee joint." Journal of Education, Health and Sport 13, no. 2 (2022): 131–35. http://dx.doi.org/10.12775/jehs.2023.13.02.018.

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Total knee replacement is one of the most widely performed surgeries. It is stated as the most efficient method of treating end-stage osteoarthritis of the knee joint. Due to the aging of the population and the prevalence of osteoarthritis, the number of arthroplasties is increasing every day. Such extensive surgical procedures are associated with a large number of postoperative complications, one of which is periprosthetic joint infection. The reported prevalence of PJI out to 2 years after knee replacement is 1.55 %. Misconceptions in the management of periprosthetic joint infection (PJI) ca

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Koutserimpas, Christos, Symeon Naoum, Vasileios Giovanoulis, et al. "Fungal Periprosthetic Hip Joint Infections." Diagnostics 12, no. 10 (2022): 2341. http://dx.doi.org/10.3390/diagnostics12102341.

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Introduction: Fungal hip prosthetic joint infections (PJIs) are rare but severe infections. Their incidence has increased in the last decades due to the aging population, as well as due to the increased number of immunosuppressed hosts. The present review of all published fungal PJIs in hip arthroplasties aims to present as much data as possible for both medical and surgical treatment options, so that the best applicable management may be concluded. Methods: A meticulous review of all published fungal hip PJIs was conducted. Information regarding demographics, causative fungus, antifungal trea

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Xu, Zhangyan. "Metal Artifact Reduction MR Imaging After Arthroplasty: Advances and Clinical Applications." Journal of Innovations in Medical Research 4, no. 2 (2025): 77–83. https://doi.org/10.63593/jimr.2788-7022.2025.04.009.

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Total joint arthroplasty was an effective treatment for end-stage joint diseases, with rapid increasement and widely applied in clinical practice. Periprosthetic joint infection remains the most severe periprosthetic complications. MRI is the preferred imaging modality for evaluating musculoskeletal infections. However, conventional MRI in post-joint arthroplasty patients was significantly hindered by severe prothesis-induced artifacts, limiting the assessment of periprosthetic structures. Metal artifact reduction imaging has been developed to mitigate metal artifacts and enhance visualization

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Tsikopoulos, Konstantinos, and Gabriele Meroni. "Periprosthetic Joint Infection Diagnosis: A Narrative Review." Antibiotics 12, no. 10 (2023): 1485. http://dx.doi.org/10.3390/antibiotics12101485.

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Replacement of native joints aims to restore patients’ quality of life by relieving pain and improving joint function. While periprosthetic joint infection (PJI) affects a small percentage of patients, with an estimated incidence of 1–9% following primary total joint replacement, this postoperative complication necessitates a lengthy hospitalisation, extended antibiotic treatment and further surgery. It is highlighted that establishing the correct diagnosis of periprosthetic infections is critical in order for clinicians to avoid unnecessary treatments in patients with aseptic failure. Of note

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Konstantinos, Tsikopoulos, Kaloudis Panagiotis, Tsikopoulos Alexios, and Papaioannidou Paraskevi. "Periprosthetic joint infections in Orthopaedics." Epitheorese Klinikes Farmakologias kai Farmakokinetikes - Greek Edition 41, no. 2 (2023): 115–19. https://doi.org/10.5281/zenodo.8421186.

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<em>Periprosthetic joint infections (PJIs) represent a serious complication following primary arthroplasty, with an incidence varying between 1% and 2%. The reason behind the high morbidity rates is the formation of biofilms on arthroplasty implants that renders antibiotic treatment less effective. With the advent of new diagnostic modalities, such as sonication, and sophisticated diagnostic criteria, sensitivity and specificity for diagnosing this post-operative complication has increased immensely. Treatment of PJIs involves a multi-disciplinary approach, including but not limited to orthopa

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Sivakon, S. V., S. V. Sretensky, N. N. Mitrofanova, V. A. Mishin, and K. Yu Murzaeva. "Main pathogens and the treatment of periprosthetic infection in modern orthopedics." Surgical practice (Russia), no. 2 (July 16, 2024): 55–68. http://dx.doi.org/10.5922/2223-2427-2024-9-2-4.

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Background. Currently, endoprosthetics is the most popular method for treating degenerative diseases and joint injuries, with the number of these operations increasing every year. Naturally, as the number of such surgical interventions rises, the frequency of postoperative complications also increases, with periprosthetic infection being the most common.Aim. To analyze data from scientific literature to determine the prevalence and main causative agents of periprosthetic infection at presentMaterials and methods. Forty-nine sources were analyzed, which were searched in the scientific databases

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Mathur, Abhay, and Antonia F. Chen. "Streptococcus viridans periprosthetic joint infections." Annals of Joint 2 (July 2017): 36. http://dx.doi.org/10.21037/aoj.2017.06.10.

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Borens, Olivier, Stéphane Corvec, and Andrej Trampuz. "Diagnosis of Periprosthetic Joint Infections." HIP International 22, no. 8_suppl (2012): 9–14. http://dx.doi.org/10.5301/hip.2012.9565.

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Palan, Jeya, Ciaran Nolan, Kostas Sarantos, Richard Westerman, Richard King, and Pedro Foguet. "Culture-negative periprosthetic joint infections." EFORT Open Reviews 4, no. 10 (2019): 585–94. http://dx.doi.org/10.1302/2058-5241.4.180067.

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Culture-negative periprosthetic joint infections (CN-PJI) pose a significant challenge in terms of diagnosis and management. The reported incidence of CN-PJI is reported to be between 7% and 15%. Fungi and mycobacterium are thought to be responsible for over 85% of such cases with more fastidious bacteria accounting for the rest. With the advent of polymerase chain reaction, mass spectrometry and next generation sequencing, identifying the causative organism(s) may become easier but such techniques are not readily available and are very costly. There are a number of more straightforward and re

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Lamret, Fabien, Marius Colin, Céline Mongaret, Sophie C. Gangloff, and Fany Reffuveille. "Antibiotic Tolerance of Staphylococcus aureus Biofilm in Periprosthetic Joint Infections and Antibiofilm Strategies." Antibiotics 9, no. 9 (2020): 547. http://dx.doi.org/10.3390/antibiotics9090547.

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The need for bone and joint prostheses is currently growing due to population aging, leading to an increase in prosthetic joint infection cases. Biofilms represent an adaptive and quite common bacterial response to several stress factors which confer an important protection to bacteria. Biofilm formation starts with bacterial adhesion on a surface, such as an orthopedic prosthesis, further reinforced by matrix synthesis. The biofilm formation and structure depend on the immediate environment of the bacteria. In the case of infection, the periprosthetic joint environment represents a particular

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Satalich, James, Julie Reznicek, Alexandra Bryson, Prayag Pershad, Nicholas Hooper, and Jibanananda Satpathy. "Prosthetic Joint Infection due to Histoplasma capsulatum in a Patient from Trinidad: Workup, Pathology, and Treatment." Case Reports in Orthopedics 2022 (August 5, 2022): 1–7. http://dx.doi.org/10.1155/2022/8998996.

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Histoplasma capsulatum is a rarely reported cause of prosthetic joint infections. This current case report is of a patient from Trinidad, with a history of a right total knee replacement (TKR), who underwent a successful two-stage revision due to a Histoplasmosis capsulatum periprosthetic joint infection (PJI). This case report offers a unique treatment plan to successfully treat Histoplasmosis capsulatum periprosthetic joint infections and emphasizes the importance of obtaining an accurate travel history.

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Legout, Laurence, and Eric Senneville. "Periprosthetic Joint Infections: Clinical and Bench Research." Scientific World Journal 2013 (2013): 1–17. http://dx.doi.org/10.1155/2013/549091.

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Prosthetic joint infection is a devastating complication with high morbidity and substantial cost. The incidence is low but probably underestimated. Despite a significant basic and clinical research in this field, many questions concerning the definition of prosthetic infection as well the diagnosis and the management of these infections remained unanswered. We review the current literature about the new diagnostic methods, the management and the prevention of prosthetic joint infections.

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Stavrakis, Alexandra I., Jared A. Niska, Amanda H. Loftin, Fabrizio Billi, and Nicholas M. Bernthal. "Understanding Infection: A Primer on Animal Models of Periprosthetic Joint Infection." Scientific World Journal 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/925906.

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Periprosthetic joint infections are devastating complications for patients and for our health system. With growing demand for arthroplasty, the incidence of these infections is projected to increase exponentially. This paper is a review of existing animal models to study periprosthetic infection aimed at providing scientists with a succinct presentation of strengths and weaknesses of available in vivo systems. These systems represent the tools available to investigate novel antimicrobial therapies and reduce the clinical and economic impact of implant infections.

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Pucar, Dragan, Zoran Jankovic, Zoran Bascarevic, Srdjan Starcevic, Milica Cizmic, and Marija Radulovic. "The role of three-phase 99mTc-MDP bone scintigraphy in the diagnosis of periprosthetic joint infection of the hip and knee." Vojnosanitetski pregled 74, no. 10 (2017): 915–20. http://dx.doi.org/10.2298/vsp160303152p.

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Background/Aim. In the last five decades primary hip and knee arthroplasty is the most common and effective surgical intervention worldwide. Infection, although unfrequented, is the most serious complication. Nuclear medicine imaging, not affected by metallic hardware, is the current imaging modality of choice for the evaluation of suspected joint replacement infection. The aim of this study was to estimate the diagnostic accuracy of three phase 99m technetium methylene diphosphonate (99mTc-MDP) bone scintigraphy in periprosthetic hip and knee joint infection. Methods. Inclusion criteria of pa

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Erem, M., E. Selçuk, M. Ozcan, G. Ozturk, and C. Eryıldız. "Exploring the Role of Sonication Fluid Culture in Periprosthetic Joint Infection: A Comparative Study with Conventional Methods." Nigerian Journal of Clinical Practice 28, no. 4 (2025): 480–86. https://doi.org/10.4103/njcp.njcp_860_23.

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Objective: The aim of this study is to evaluate and compare the diagnostic effectiveness of sonication fluid culture (SFC) compared to conventional methods in identifying the causative microorganisms in periprosthetic joint infections. Methods: In this study, three cultures were evaluated for diagnosing periprosthetic joint infection intraoperative periprosthetic tissue culture, implant culture, and SFC. The sensitivity, specificity, and predictive values were calculated for each method, using the 2018 definition of periprosthetic hip and knee infection and clinical evaluation as references. O

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Yang, Theodore, FNU Shweta, Marcus Greatens, and Jonathan Webb. "Lyme disease periprosthetic joint infection." BMJ Case Reports 18, no. 1 (2025): e261837. https://doi.org/10.1136/bcr-2024-261837.

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Periprosthetic joint infection (PJI) is a devastating complication of total joint surgery. Surgical management of PJI has increased surgical risks and is costly to the healthcare system. This case study presents a unique clinical scenario involving a patient who was diagnosed with Lyme PJI at the total knee arthroplasty site after undergoing surgical management. Lyme PJI is a rare condition, and there is limited guidance on the diagnosis and management of this condition. It should be considered in the differential of certain individuals with appropriate epidemiological risk factors. This repor

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Bori, G., M. A. McNally, and N. Athanasou. "Histopathology in Periprosthetic Joint Infection: When Will the Morphomolecular Diagnosis Be a Reality?" BioMed Research International 2018 (2018): 1–10. http://dx.doi.org/10.1155/2018/1412701.

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The presence of a polymorphonuclear neutrophil infiltrate in periprosthetic tissues has been shown to correlate closely with the diagnosis of septic implant failure. The histological criterion considered by the Musculoskeletal Infection Society to be diagnostic of periprosthetic joint infection is “greater than five neutrophils per high-power field in five high-power fields observed from histologic analysis of periprosthetic tissue at ×400 magnification.” Surgeons and pathologists should be aware of the qualifications introduced by different authors during the last years in the histological te

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Küçükdurmaz, Fatih, and Javad Parvizi. "The Prevention of Periprosthetic Joint Infections." Open Orthopaedics Journal 10, no. 1 (2016): 589–99. http://dx.doi.org/10.2174/1874325001610010589.

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Periprosthetic joint infection (PJI) following total joint arthroplasty (TJA) adversely affects patient quality of life and health status, and places a huge financial burden on the health care. The first step in combating this complication is prevention, which may include implementation of strategies during the preoperative, intraoperative, or postoperative period. Optimization of the patient with appreciation of the modifiable and non-modifiable factors is crucial. Preoperative optimization involves medical optimization of patients with comorbidities such as diabetes, anemia, malnutrition and

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Saleh, A., J. George, M. Faour, A. K. Klika, and C. A. Higuera. "Serum biomarkers in periprosthetic joint infections." Bone & Joint Research 7, no. 1 (2018): 85–93. http://dx.doi.org/10.1302/2046-3758.71.bjr-2017-0323.

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ObjectivesThe diagnosis of periprosthetic joint infection (PJI) is difficult and requires a battery of tests and clinical findings. The purpose of this review is to summarize all current evidence for common and new serum biomarkers utilized in the diagnosis of PJI.MethodsWe searched two literature databases, using terms that encompass all hip and knee arthroplasty procedures, as well as PJI and statistical terms reflecting diagnostic parameters. The findings are summarized as a narrative review.ResultsErythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were the two most commonly

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FREEMAN, SARA. "Biologics Don't Up Periprosthetic Joint Infections." Rheumatology News 10, no. 7 (2011): 13. https://doi.org/10.1016/s1541-9800(11)70437-9.

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Galanis, Athanasios, Spyridon Karampitianis, John Vlamis, et al. "Corynebacterium striatum Periprosthetic Hip Joint Infection: An Uncommon Pathogen of Concern?" Healthcare 12, no. 2 (2024): 273. http://dx.doi.org/10.3390/healthcare12020273.

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Background: Total hip arthroplasty is indubitably a dominant elective surgery in orthopaedics, contributing to prodigious improvement in the quality of life of patients with osteoarthritis. One of the most potentially devastating complications of this operation is periprosthetic joint infection. Immunocompromised patients might be afflicted by infrequent low-virulence organisms not typically detected with conventional procedures. Consequently, employing advanced identification methods, such as the circumstantial sonication of orthopaedic implants, could be crucial to managing such cases. Case

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Warne, Christopher N., Sean Ryan, Elizabeth Yu, Douglas R. Osmon, Daniel J. Berry, and Matthew P. Abdel. "Cutibacterium acnes periprosthetic joint infections." Bone & Joint Journal 106-B, no. 12 (2024): 1426–30. https://doi.org/10.1302/0301-620x.106b12.bjj-2024-0437.r1.

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AimsCutibacterium acnes (C. acnes; previously known as Propionibacterium acnes or P. acnes) periprosthetic hip and knee infections are under-reported. While culture contamination with C. acnes occurs, true infections are important to recognize and treat. We sought to describe the demographics and treatment outcomes of patients with C. acnes periprosthetic joint infections (PJIs) of the hip and knee.MethodsPatients with C. acnes PJI between January 2005 and December 2018 were retrospectively reviewed utilizing the institutional total joint registry. Patients with monomicrobial PJI and two or mo

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Roschke, E., T. Kluge, F. Stallkamp, et al. "Use of PET-CT in diagnostic workup of periprosthetic infection of hip and knee joints: significance in detecting additional infectious focus." International Orthopaedics 46, no. 3 (2021): 523–29. http://dx.doi.org/10.1007/s00264-021-05218-8.

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Abstract Introduction The diagnosis and management of periprosthetic knee and hip infections as well as the identification and management of possible additional infectious foci is of great importance for successful therapy. This study analyses the importance of 18F deoxyglucose PET-CT (PET-CT) in the identification of additional infectious focus and subsequent impact on management of periprosthetic infection (PPI). Material and methods A retrospective analysis of the clinical data and findings in the period from January 2008 to December 2018 was carried out. One hundred and four patients with

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Masters, Thao, Aditya Bhagwate, Mrunal Dehankar, et al. "1193. Human Transcriptomic Analysis of Periprosthetic Joint Infection." Open Forum Infectious Diseases 7, Supplement_1 (2020): S619. http://dx.doi.org/10.1093/ofid/ofaa439.1378.

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Abstract Background Periprosthetic joint infection (PJI), a devastating complication of total joint replacement, is of incompletely understood pathogenesis and may sometimes be challenging to clinically distinguish from other causes of arthroplasty failure. Methods We characterized human gene expression in 93 specimens derived from surfaces of resected arthroplasties, comparing transcriptomes of subjects with infection- versus non-infection-associated arthroplasty failure. Results Differential gene expression analysis confirmed the association of 28 previously investigated biomarkers with PJI-

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McNally, Martin, Ricardo Sousa, Marjan Wouthuyzen-Bakker, et al. "The EBJIS definition of periprosthetic joint infection." Bone & Joint Journal 103-B, no. 1 (2021): 18–25. http://dx.doi.org/10.1302/0301-620x.103b1.bjj-2020-1381.r1.

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Aims The diagnosis of periprosthetic joint infection (PJI) can be difficult. All current diagnostic tests have problems with accuracy and interpretation of results. Many new tests have been proposed, but there is no consensus on the place of many of these in the diagnostic pathway. Previous attempts to develop a definition of PJI have not been universally accepted and there remains no reference standard definition. Methods This paper reports the outcome of a project developed by the European Bone and Joint Infection Society (EBJIS), and supported by the Musculoskeletal Infection Society (MSIS)

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Schindler, Melanie, Nike Walter, Irene Katharina Sigmund, Günther Maderbacher, Volker Alt, and Markus Rupp. "NOVEL DIAGNOSIS MARKER OF PERIPROSTHETIC JOINT INFECTION: A SYSTEMATIC REVIEW." Orthopaedic Proceedings 105-B, SUPP_17 (2023): 65. http://dx.doi.org/10.1302/1358-992x.2023.17.065.

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BackgroundThe identification of novel biomarker which is highly specific and sensitive for periprosthetic joint (PJI) have the potential to improve diagnostic accuracy and ultimately improve patient outcomes. Thus, the aim of this systemic review is to identify and evaluate novel biomarkers for the preoperative diagnostics of PJI.MethodsMEDLINE, EMBASE, PubMed and Cochrane Library databases identified from 1st of January 2018 to 30th of September. 2022. We used “periprosthetic joint infection” OR “prosthetic joint infection” OR “periprosthetic infection” as the diagnosis of interest and the ta

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Vrancianu, Corneliu Ovidiu, Bogdan Serban, Irina Gheorghe-Barbu, et al. "The Challenge of Periprosthetic Joint Infection Diagnosis: From Current Methods to Emerging Biomarkers." International Journal of Molecular Sciences 24, no. 5 (2023): 4320. http://dx.doi.org/10.3390/ijms24054320.

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Due to the increase in the life span and mobility at older ages, the number of implanted prosthetic joints is constantly increasing. However, the number of periprosthetic joint infections (PJIs), one of the most severe complications after total joint arthroplasty, also shows an increasing trend. PJI has an incidence of 1–2% in the case of primary arthroplasties and up to 4% in the case of revision operations. The development of efficient protocols for managing periprosthetic infections can lead to the establishment of preventive measures and effective diagnostic methods based on the results ob

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VANDENBERK, L., G. F. VLES, I. DERDELINCKX, et al. "Brucella melitensis periprosthetic joint infection:." Acta Orthopaedica Belgica 90, no. 4 (2024): 759–67. https://doi.org/10.52628/90.4.13281.

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Brucellosis, caused by a facultative intracellular gram-negative coccobacillus, is one of the most common zoonotic infections worldwide. Very rarely, brucellosis can cause periprosthetic joint infections (PJI). In this case-based literature review, we summarize the current medical literature regarding Brucella PJI, with the aim to raise awareness among clinicians, particularly in non-endemic areas. We report a case of a woman with a 3 weeks history of increasing hip pain, who was eventually diagnosed with Brucella PJI. We searched multiple databases to identify all case reports on Brucella PJI

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Bulycheva, Irina A., Ksenija A. Kondratieva, Gulnara R. Yakupova, Alla I. Lokotkova, Eldar Kh Mamkeev, and Marat R. Mazitov. "Epidemiological surveillance of surgical site infections in large joint replacement." Kazan medical journal 103, no. 2 (2022): 221–29. http://dx.doi.org/10.17816/kmj2022-221.

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Joint replacement is a reliable and effective surgery that allows profound pain relief and restores joint function in patients. Despite the progress made and the experience gained in joint replacement, surgical site infection is one of the leading postoperative complications. It can proceed as a periprosthetic joint infection, osteomyelitis, sepsis and lead to disabled or dead outcomes. Systematization of risk factors for infectious complications plays an important role as an element of epidemiological surveillance system optimization. Age, the presence of concomitant diseases (for example, di

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Marongiu, Giuseppe, Marco Conte, Vincenzo Verderosa, et al. "Late onset periprosthetic joint infection of the knee caused by Streptococcus anginosus. Case presentation and literature review." Journal of Infection in Developing Countries 15, no. 03 (2021): 436–41. http://dx.doi.org/10.3855/jidc.12326.

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Periprosthetic joint infection (PJI) is one of the most dramatic complications of joint arthroplasty. Although streptococcal bone and joint infections are less common than staphylococcal cases, their role as causative agents of bone and joint remains significant accounting for at least 10% of PJIs. Streptococcus anginosus group (SAG) bacteria are usually found in the normal flora of the urogenital tract, intestinal tract and oropharynx and could cause pyogenic infections to affect brain, lungs and liver. SAG bacteria are uncommonly reported as a cause of osteomyelitis and the involvement of a

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Johns, Brenton P., David C. Dewar, Mark R. Loewenthal, et al. "A desirability of outcome ranking (DOOR) for periprosthetic joint infection – a Delphi analysis." Journal of Bone and Joint Infection 7, no. 6 (2022): 221–29. http://dx.doi.org/10.5194/jbji-7-221-2022.

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Abstract. Background: Treatment outcomes in studies on prosthetic joint infection are generally assessed using a dichotomous outcome relating to treatment success or failure. These outcome measures neither include patient-centred outcome measures including joint function and quality of life, nor do they account for adverse effects of treatment. A desirability of outcome ranking (DOOR) measure can include these factors and has previously been proposed and validated for other serious infections. We aimed to develop a novel DOOR for prosthetic joint infections (PJIs). Methods: The Delphi method w

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Tiwari, Vivek, Pooja Shendre, Soumyabrata Nag, Meena Mishra, Mainak Roy, and Samir Dwidmuthe. "Peri-prosthetic Joint Infection due to Candida albicans in a Young Immunocompetent Patient – A Rare Case Report." Journal of Orthopaedic Case Reports 14, no. 2 (2024): 160–64. http://dx.doi.org/10.13107/jocr.2024.v14.i02.4256.

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Introduction: The recent surge in joint replacement surgeries in India, particularly total knee and hip replacements, is notable. The majority of patients undergoing these procedures suffered from knee osteoarthritis or femoral head avascular necrosis. However, this increase in joint replacements has also led to a rise in periprosthetic joint infections (PJI), a severe and costly complication. PJI is responsible for 25% of total knee arthroplasty failures and 15% of total hip arthroplasty failures. Various risk factors, such as diabetes, fractures, and arthritis, are associated with PJI develo

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Ozdemir, Guzelali, Niyazi Yasar, Alper Deveci, Olgun Bingol, Erman Ceyhan, and Sualp Turan. "Periprosthetic joint infections are different from osteosynthesis-associated infections." Annals of Medical Research 28, no. 6 (2021): 1099. http://dx.doi.org/10.5455/annalsmedres.2020.04.345.

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De Mauro, Domenico, Cesare Meschini, Giovanni Balato, et al. "Sex-related differences in periprosthetic joint infection research." Journal of Bone and Joint Infection 9, no. 2 (2024): 137–42. http://dx.doi.org/10.5194/jbji-9-137-2024.

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Abstract. Introduction: Periprosthetic joint infections (PJIs) have emerged as a focal point in the realm of orthopedics, garnering widespread attention owing to the escalating incidence rates and the profound impact they impose on patients undergoing total joint arthroplasties (TJAs). Year after year, there has been a growing trend in the analysis of multiple risk factors, complication rates, and surgical treatments in the field. This study aims to illuminate the status of the sex-related differences in periprosthetic joint infections and advance research in this field. Methods: A systematic

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Tubb, Creighton C., Gregory G. Polkowksi, and Barbara Krause. "Diagnosis and Prevention of Periprosthetic Joint Infections." Journal of the American Academy of Orthopaedic Surgeons 28, no. 8 (2020): e340-e348. http://dx.doi.org/10.5435/jaaos-d-19-00405.

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Anagnostakos, Konstantinos, Jens Kelm, Eduard Schmitt, and Jochen Jung. "Fungal Periprosthetic Hip and Knee Joint Infections." Journal of Arthroplasty 27, no. 2 (2012): 293–98. http://dx.doi.org/10.1016/j.arth.2011.04.044.

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&NA;. "AAOS Issues Guideline for Periprosthetic Joint Infections." Lippincott's Bone and Joint Newsletter 17, no. 1 (2011): 6–7. http://dx.doi.org/10.1097/01.bonej.0000392942.59843.5e.

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Higuera-Rueda, Carlos A. "Periprosthetic Joint Infections in Total Knee Arthroplasty." Journal of Knee Surgery 33, no. 02 (2020): 099. http://dx.doi.org/10.1055/s-0040-1701248.

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Akcaalan, Serhat, Halil Ibrahim Ozaslan, Ceyhun Caglar, Mehmet Emin Şimşek, Mustafa Citak, and Mustafa Akkaya. "Role of Biomarkers in Periprosthetic Joint Infections." Diagnostics 12, no. 12 (2022): 2958. http://dx.doi.org/10.3390/diagnostics12122958.

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Periprosthetic joint infection (PJI) is one of the most serious complications after joint arthroplasty. The incidence rate of PJI after total joint replacement is 1–3%. Although there are different guidelines and diagnostic criteria used to diagnose PJI, diagnosing PJI is a highly difficult process for orthopedists. The current Musculoskeletal Infection Society (MSIS) criteria are widely used for the diagnosis of PJI. These criteria include results from blood/synovial fluid tests, physical examination, and histological and microbiological analyses of intra-operative samples. However, there is

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Ekici, Mehmet, Muhammed Ali Demir, and Sait Dalyan. "The role of C-reactive protein to procalcitonin ratio in detecting early periprosthetic joint infections after total joint arthroplasty." Journal of Multidisciplinary Orthopaedic Surgery 1, no. 1 (2025): 1–5. https://doi.org/10.5281/zenodo.15108554.

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Abstract <strong>Background: </strong>Periprosthetic joint infection (PJI) is a severe complication following total joint arthroplasty (TJA), leading to significant morbidity and mortality. Early diagnosis is crucial for effective treatment. The C-reactive protein / procalcitonin (CRP / PCT) ratio has emerged as a potential biomarker for the early detection of PJIs. This study aims to evaluate the utility of the CRP / PCT ratio in diagnosing early-stage PJIs following total knee arthroplasty (TKA). <strong>Methods:</strong><strong> </strong>A prospective cross-sectional study was con

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