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Journal articles on the topic 'Peritumoral area'

Author: Grafiati

Published: 6 July 2024

Last updated: 31 July 2025

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1

Tabacaru, Gigi, Simona Moldovanu, and Marian Barbu. "Algorithm for Analyzing the Microenvironment Surrounding Melanoma." SYSTEM THEORY, CONTROL AND COMPUTING JOURNAL 3, no. 2 (2023): 15–19. http://dx.doi.org/10.52846/stccj.2023.3.2.52.

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Peritumoral areas or microenvironments surrounding melanoma are unexplored and partially understood, so that, in the following paper, an algorithm that predicts the trend of the melanoma progression is proposed. Additionally, in case of melanoma the peritumoral area is significantly correlated with the texture that belongs inside the skin lesion. The proposed algorithm analyses the region of interest (ROI) with Normalized 2-D cross-correlation (NCC) method and predicts the pattern in the peritumoral area which is most similar with the texture of the melanoma. An important step is the detection

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Ly, Ina, Barbara Wichtmann, Susie Yi Huang, et al. "Characterizing glioma microenvironment with ultra-high gradient diffusion MRI." Journal of Clinical Oncology 35, no. 15_suppl (2017): 2050. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.2050.

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2050 Background: The infiltrating nature of gliomas, particularly into the peritumoral area, is a major barrier to improving clinical outcome as microscopic disease remains even after apparent gross total resection. Conventional T1 post-contrast and T2/FLAIR MRI do not capture full tumor extent. A better imaging biomarker is needed to improve differentiation between tumor, peritumoral area and normal brain. Methods: 4 pre-surgical patients with non-enhancing, FLAIR-hyperintense lesions suspicious for glioma underwent ultra-high gradient diffusion MRI on the Connectome MRI scanner, a unique sca

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Tatagiba, Marcos, Shahram Mirzai, and Madjid Samii. "Peritumoral Blood Flow in Intracranial Meningiomas." Neurosurgery 28, no. 3 (1991): 400–404. http://dx.doi.org/10.1227/00006123-199103000-00010.

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Abstract Blood flow was measured in intratumoral tissue, the cerebral hemispheres and particularly in the peritumoral area of 12 patients with intracranial meningiomas using the stable xenon-enhanced computed tomographic scan. Tumor blood flow frequently showed a heterogeneous pattern of enhancement with high flow at the tumor periphery and a central area of hypoperfusion. Blood flow values were on average 28% lower in the peritumoral area than in the ipsilateral cerebral hemisphere. In individual cases, blood flow values in the peritumoral edematous area were very low. These findings suggest

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Kumala Wardani, Bestia, Yuyun Yueniwati, and Agus Naba. "The Application of Image Segmentation to Determine the Ratio of Peritumoral Edema Area to Tumor Area on Primary Malignant Brain Tumor and Metastases through Conventional Magnetic Resonance Imaging." Open Access Macedonian Journal of Medical Sciences 10, B (2022): 26–30. http://dx.doi.org/10.3889/oamjms.2022.7777.

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 BACKGROUND: Primary malignant brain tumor and metastases on the brain have a similar pattern in conventional Magnetic Resonance Imaging (MRI), even though both require entirely different treatment and management. The pathophysiological difference of peritumoral edema can help to distinguish the case of primary malignant brain tumor and brain metastases.    AIM: This study aimed to analyze the ratio of the area of peritumoral edema to the tumor using Otsu’s method of image segmentation technique with a user-friendly Graphical User Interface (GUI).    M

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Gao, Xiang, Haiyan Wang, Shanbao Cai, et al. "Phosphorylation of NMDA 2B at S1303 in human glioma peritumoral tissue: implications for glioma epileptogenesis." Neurosurgical Focus 37, no. 6 (2014): E17. http://dx.doi.org/10.3171/2014.9.focus14485.

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Object Peritumoral seizures are an early symptom of a glioma. To gain a better understanding of the molecular mechanism underlying tumor-induced epileptogenesis, the authors studied modulation of the N-methyl-d-aspartate (NMDA) receptor in peritumoral tissue. Methods To study the possible etiology of peritumoral seizures, NMDA receptor expression, posttranslational modification, and function were analyzed in an orthotopic mouse model of human gliomas and primary patient glioma tissue in which the peritumoral border (tumor-brain interface) was preserved in a tissue block during surgery. Results

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Carpenco, Ecaterina. "Tumor associated macrophages in breast cancer." Moldovan Medical Journal 62 (1) (March 15, 2019): 24–27. https://doi.org/10.5281/zenodo.2590003.

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<strong>Background: </strong>Cancer research was focused on the studying of proper tumor cells for a long time. Despite the huge progress, there are still a lot of questions, that’s why new molecular markers must be identified. These could reveal new information about tumorigenesis. <strong>Material and methods: </strong>15 cases of ductal invasive breast carcinomas have been analyzed and researched on tumor associated macrophages via immunohistochemistry. CD68 was used as a macrophage marker and CD68<sup>+</sup> cells were evaluated in tumor nest and peritumoral area, as well as hormone

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Samani, Zahra Riahi, Drew Parker, Jacob Antony Alappatt, Steven Brem, and Ragini Verma. "NIMG-21. DIFFERENTIATING TUMOR TYPES BASED ON THE PERITUMORAL MICROENVIRONMENT USING CONVOLUTIONAL NEURAL NETWORKS." Neuro-Oncology 22, Supplement_2 (2020): ii151. http://dx.doi.org/10.1093/neuonc/noaa215.634.

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Abstract PURPOSE The differential diagnosis of glioblastoma (GBM) versus single brain metastasis (Met) is clinically important, and is undertaken with a clinical reading of MR images and/or tumor biopsy. We investigate whether Mets and GBMs can be differentiated based on the microstructure of the FLAIR-hyperintense peritumoral region measured by diffusion tensor imaging (DTI). We hypothesize that the peritumoral microstructure differs in extracellular water content, based on whether it is vasogenic edema or infiltrative. We use deep learning trained on DTI-based free-water volume fraction maps

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Danilova, N. V., V. M. Kkomyakov, A. V. Chayka, I. A. Mikhailov, N. A. Oleynikova, and P. G. Malkov. "CHARACTERISTICS OF THE IMMUNE MICROENVIRONMENT OF THE NORMAL MUCOUS MEMBRANE OF THE PERITUMORAL AREA IS AN ADDITIONAL INDEPENDENT PROGNOSTIC FACTOR IN GASTRIC CANCER." Siberian journal of oncology 20, no. 1 (2021): 74–86. http://dx.doi.org/10.21294/1814-4861-2021-20-1-74-86.

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The aim of the study was to study and evaluate the predictive value of the immune microenvironment of gastric cancer and morphologically normal mucous membrane of the peritumoral area using an automatic morphometric analysis system on the example of CD 8+ cells.Material and Methods. Surgical samples from 130 patients with a verified diagnosis of gastric cancer were used. After immunohistochemical staining with antibodies to CD 8, a morphological assessment was performed according to the original method. We assessed the average area of CD 8+ cells in three fields of view (lens magn. ×20) using

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Samani, Zahra Riahi, Drew Parker, Jacob Antony Alappatt, Steven Brem, and Ragini Verma. "NIMG-45. DEEP LEARNING-BASED PERITUMORAL MICROSTRUCTURE MAPPING IN GLIOBLASTOMAS USING FREE WATER VOLUME FRACTION." Neuro-Oncology 22, Supplement_2 (2020): ii157—ii158. http://dx.doi.org/10.1093/neuonc/noaa215.658.

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Abstract PURPOSE Characterization of the peritumoral microenvironment is a widely researched, but as yet unsolved problem. Determining the tissue microstructure differences between tumor types, arising from differences in infiltration, edema, and disease driven changes in cellularity is important to be able to guide treatment options. Diffusion tensor imaging with characterization of extracellular free water provides unique information of the tissue microstructure. The goal of this work is to leverage this information by applying deep learning on free water maps and create a microstructure map

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Monika Mehjabin, Abdus Sabur Talukder, Sabera sultana, Nure Jannat Ferdousi, Umme Kulsum Munmun, and Mohammed Kamal. "Prognostic Significance of Angiogenesis in invasive ductal carcinoma." Journal of Shaheed Suhrawardy Medical College 15, no. 1 (2024): 59–65. http://dx.doi.org/10.3329/jssmc.v15i1.76921.

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Background: Angiogenesis is essential for tumor growth and metastasis. Axillary lymphnode status has been the most important prognostic factor in operable breast carcinoma, but it does not fully account for the varied disease outcome. More accurate prognostic indicators would help in selection of patients at high risk for disease recurrence and death who are candidates for systemic adjuvant therapy. Microvessel density in invasive ductal carcinoma (measures of tumor angiogenesis) is associated with metastasis and thus may be a prognostic indicator. Objective: To correlate intratumoral and peri

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Yan, Jiun-Lin, Chao Li, Natalie R. Boonzaier, et al. "Multimodal MRI characteristics of the glioblastoma infiltration beyond contrast enhancement." Therapeutic Advances in Neurological Disorders 12 (January 2019): 175628641984466. http://dx.doi.org/10.1177/1756286419844664.

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Our inability to identify the invasive margin of glioblastomas hampers attempts to achieve local control. Diffusion tensor imaging (DTI) has been implemented clinically to delineate the margin of the tumor infiltration, its derived anisotropic (q) values can extend beyond the contrast-enhanced area and correlates closely with the tumor. However, its correlation with tumor infiltration shown on multivoxel proton magnetic resonance spectroscopy1 (MRS) and perfusion magnetic resonance imaging (MRI) should be investigated. In this study, we aimed to show tissue characteristics of the q-defined per

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Zhao, Xinyao, Qingqing Wen, Junying Wang, Weiqiang Dou, Guowei Zhang, and Hao Shi. "Is intravoxel incoherent motion magnetic resonance imaging useful for predicting hepatocellular cancer recurrence and invasion of the peritumoral zone after transarterial chemoembolization?" Journal of Cancer Research and Therapeutics 20, no. 2 (2024): 584–91. http://dx.doi.org/10.4103/jcrt.jcrt_1582_23.

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ABSTRACT Purpose: We evaluated the potential role of intravoxel incoherent motion (IVIM) in predicting the therapeutic response and peritumoral invasion in patients with hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE). Materials and Methods: We enrolled 47 patients previously treated with TACE between January 2018 and December 2021. We evaluated the IVIM-derived metrics [apparent diffusion coefficient (ADC), D, D*, f] in the TACE-treated, peritumoral, and parenchymal areas of the liver. Results: The ADCtace and Dtace values (1.13 ± 0.22 × 10−3 m2/s vs 0.95 ±

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Boia, Eugen Radu, Simina Boia, Raluca Amalia Ceausu, et al. "The Follicular Dendritic Cells and HPV 18 Interrelation in Head and Neck Squamous Cell Carcinomas of the Larynx." Medicina 59, no. 6 (2023): 1072. http://dx.doi.org/10.3390/medicina59061072.

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Background and Objectives: Even if they are cells of controversial origin (mesenchymal, perivascular, or fibroblastic), follicular dendritic cells (FDC) are present in all organs. The aim of this study was to establish the FDC expression pattern and its interrelation with HPV 18 expression in laryngeal squamous cell carcinoma (LSCC). Materials and Methods: Fifty-six cases of LSCC were evaluated by simple and double immunostaining. The following score was used: 0 (negative or few positive cells), 1 (10–30% of positive cells), 2 (30–50% of cells), and 3 (over 50% of cells). Results: The expressi

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Korbecki, Jan, Klaudyna Kojder, Dariusz Jeżewski, et al. "Expression of SCD and FADS2 Is Lower in the Necrotic Core and Growing Tumor Area than in the Peritumoral Area of Glioblastoma Multiforme." Biomolecules 10, no. 5 (2020): 727. http://dx.doi.org/10.3390/biom10050727.

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The expression of desaturases is higher in many types of cancer, and despite their recognized role in oncogenesis, there has been no research on the expression of desaturases in glioblastoma multiforme (GBM). Tumor tissue samples were collected during surgery from 28 patients (16 men and 12 women) diagnosed with GBM. The effect of necrotic conditions and nutritional deficiency (mimicking conditions in the studied tumor zones) was studied in an in vitro culture of human brain (glioblastoma astrocytoma) U-87 MG cells. Analysis of desaturase expression was made by qRT-PCR and the immunohistochemi

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Manish, Kumar Jha, Imteyaz Alam Md., Bharti Madhu, and Kumari Poonam. "A Hospital Based Observational Assessment of the Histopathology of Benign Proliferative Breast Lesions in Peritumoral Area of Carcinoma Breast." International Journal of Current Pharmaceutical Review and Research 15, no. 08 (2023): 144–48. https://doi.org/10.5281/zenodo.12543741.

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AbstractAim: The aim of the study was to determine histopathological features of different subtypes of carcinoma breastand correlate with the presence of proliferative lesions of breast in peritumoral area.Methods: This Observational study was conducted for a period of 1 year at department of Pathology,Darbhanga Medical College and Hospital, Darbhanga, Bihar, India and A total of 100 cases that satisfied theinclusion criteria were included in this study. Specimens were received in 10% Formalin. Clinical details, grossfindings including tumor size were noted.Results: Age group of patients inclu

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Zimmermann, Mona, Lucas Breedt, Eduarda Centeno, et al. "CNSC-10. THE COMPLEX RELATIONSHIP BETWEEN NEURONAL ACTIVITY AND FUNCTIONAL NETWORK PROPERTIES IN GLIOMA PATIENTS." Neuro-Oncology 24, Supplement_7 (2022): vii23—vii24. http://dx.doi.org/10.1093/neuonc/noac209.091.

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Abstract BACKGROUND Glioma is associated with pathologically high peritumoral neuronal activity, which associates with faster tumor progression. Concurrently, glioma patients have local and widespread disturbances of the functional brain network as measured with magnetoencephalography (MEG), such as higher network clustering (the extent to which regions connected to a particular area are also connected to each other) and locally altered integrative connectivity (for instance assessed with a centrality measure). How local neuronal activity and nodal network properties relate to each other has y

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Deeg, Johannes, Michael Swoboda, Daniel Egle, et al. "Shear-Wave Elastography Gradient Analysis of Newly Diagnosed Breast Tumours: A Critical Analysis." Diagnostics 14, no. 15 (2024): 1657. http://dx.doi.org/10.3390/diagnostics14151657.

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Background: A better understanding of the peritumoral stroma changes due to tumour invasion using non-invasive diagnostic methods may improve the differentiation between benign and malignant breast lesions. This study aimed to assess the correlation between breast lesion differentiation and intra- and peritumoral shear-wave elastography (SWE) gradients. Methods: A total of 135 patients with newly diagnosed breast lesions were included. Intratumoral, subsurface, and three consecutive peritumoral SWE value measurements (with three repetitions) were performed. Intratumoral, interface, and peritum

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Zhang, L., T. Yoshimura, and D. T. Graves. "Antibody to Mac-1 or monocyte chemoattractant protein-1 inhibits monocyte recruitment and promotes tumor growth." Journal of Immunology 158, no. 10 (1997): 4855–61. http://dx.doi.org/10.4049/jimmunol.158.10.4855.

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Abstract Human tumors are frequently infiltrated by numerous monocytes/macrophages, which can be found within the tumor mass (intratumoral) or surrounding the tumor (peritumoral). The functional role that these monocytes/macrophages play in tumor growth is controversial. To address this issue we inhibited intratumoral monocyte/macrophage recruitment with mAbs that either blocked integrin function or neutralized a tumor-produced chemotactic protein. Both treatments significantly increased tumor formation and accelerated tumor growth. Surprisingly, the same results were obtained when recruitment

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Cherdantseva, T. M., I. P. Bobrov, I. V. Klimachev, and V. N. Baranov. "Proliferative and apoptotic processes in peritumoral area of kidney cancer." Russian Journal of Oncology 20, no. 4 (2015): 50–51. http://dx.doi.org/10.17816/onco40270.

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Angelucci, Cristiana, Alessio D’Alessio, Silvia Sorrentino, et al. "Immunohistochemical Analysis of DNA Repair- and Drug-Efflux-Associated Molecules in Tumor and Peritumor Areas of Glioblastoma." International Journal of Molecular Sciences 22, no. 4 (2021): 1620. http://dx.doi.org/10.3390/ijms22041620.

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Glioblastoma (GBM), the most commonly occurring primary tumor arising within the central nervous system, is characterized by high invasiveness and poor prognosis. In spite of the improvement in surgical techniques, along with the administration of chemo- and radiation therapy and the incessant investigation in search of prospective therapeutic targets, the local recurrence that frequently occurs within the peritumoral brain tissue makes GBM the most malignant and terminal type of astrocytoma. In the current study, we investigated both GBM and peritumoral tissues obtained from 55 hospitalized p

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Fuster-Garcia, Elies, Ivar Thokle Hovden, Siri Fløgstad Svensson, et al. "Quantification of Tissue Compression Identifies High-Grade Glioma Patients with Reduced Survival." Cancers 14, no. 7 (2022): 1725. http://dx.doi.org/10.3390/cancers14071725.

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The compression of peritumoral healthy tissue in brain tumor patients is considered a major cause of the life-threatening neurologic symptoms. Although significant deformations caused by the tumor growth can be observed radiologically, the quantification of minor tissue deformations have not been widely investigated. In this study, we propose a method to quantify subtle peritumoral deformations. A total of 127 MRI longitudinal studies from 23 patients with high-grade glioma were included. We estimate longitudinal displacement fields based on a symmetric normalization algorithm and we propose f

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Schmitz, Fabian, Hendrik Voigtländer, Hyungseok Jang, Heinz-Peter Schlemmer, Hans-Ulrich Kauczor, and Sam Sedaghat. "Predicting the Malignancy Grade of Soft Tissue Sarcomas on MRI Using Conventional Image Reading and Radiomics." Diagnostics 14, no. 19 (2024): 2220. http://dx.doi.org/10.3390/diagnostics14192220.

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Objectives: This study aims to investigate MRI features predicting the grade of STS malignancy using conventional image reading and radiomics. Methods: Pretherapeutic imaging data regarding size, tissue heterogeneity, peritumoral changes, necrosis, hemorrhage, and cystic degeneration were evaluated in conventional image reading. Furthermore, the tumors’ apparent diffusion coefficient (ADC) values and radiomics features were extracted and analyzed. A random forest machine learning algorithm was trained and evaluated based on the extracted features. Results: A total of 139 STS cases were include

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López, Carlos, Ramón Bosch-Príncep, Guifré Orero, et al. "Peritumoral immune infiltrates in primary tumours are not associated with the presence of axillary lymph node metastasis in breast cancer: a retrospective cohort study." PeerJ 8 (September 2, 2020): e9779. http://dx.doi.org/10.7717/peerj.9779.

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Background The axillary lymph nodes (ALNs) in breast cancer patients are the body regions to where tumoral cells most often first disseminate. The tumour immune response is important for breast cancer patient outcome, and some studies have evaluated its involvement in ALN metastasis development. Most studies have focused on the intratumoral immune response, but very few have evaluated the peritumoral immune response. The aim of the present article is to evaluate the immune infiltrates of the peritumoral area and their association with the presence of ALN metastases. Methods The concentration o

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Greco, Federico, Luigi Giuseppe Quarta, Rosario Francesco Grasso, Bruno Beomonte Zobel, and Carlo Augusto Mallio. "Increased visceral adipose tissue in clear cell renal cell carcinoma with and without peritumoral collateral vessels." British Journal of Radiology 93, no. 1112 (2020): 20200334. http://dx.doi.org/10.1259/bjr.20200334.

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Objective: The excessive amount of adipose tissue, mainly visceral, determines adiposopathy. With respect to oncogenesis, visceral adipose tissue (VAT) releases secretes adipokines, proinflammatory citokines and growth factors, considered mediating molecules in the development of obesity-related tumors. In this study, we quantify VAT in male patients with clear cell renal cell carcinoma (ccRCC) subgrouped according to the presence or absence of peritumoral collateral vessels. Methods: in this retrospective study, we enrolled 141 male caucasian patients divided into 2 groups: the ccRCC group (n

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Chiu, Fang-Ying, Nguyen Quoc Khanh Le, and Cheng-Yu Chen. "A Multiparametric MRI-Based Radiomics Analysis to Efficiently Classify Tumor Subregions of Glioblastoma: A Pilot Study in Machine Learning." Journal of Clinical Medicine 10, no. 9 (2021): 2030. http://dx.doi.org/10.3390/jcm10092030.

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Glioblastoma multiforme (GBM) carries a poor prognosis and usually presents with heterogenous regions of a necrotic core, solid part, peritumoral tissue, and peritumoral edema. Accurate demarcation on magnetic resonance imaging (MRI) between the active tumor region and perifocal edematous extension is essential for planning stereotactic biopsy, GBM resection, and radiotherapy. We established a set of radiomics features to efficiently classify patients with GBM and retrieved cerebral multiparametric MRI, including contrast-enhanced T1-weighted (T1-CE), T2-weighted, T2-weighted fluid-attenuated

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Lee, Hongseok, Kyungdoc Kim, Guhyun Kang, Kyu-Hwan Jung, and Sunyoung S. Lee. "Abstract 1721: Spatial distribution of immune cells as quantitative prognosis indicator in hepatocellular carcinoma." Cancer Research 82, no. 12_Supplement (2022): 1721. http://dx.doi.org/10.1158/1538-7445.am2022-1721.

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Abstract Background: We previously demonstrated that the analysis of the tumor microenvironment (TME) in histopathology images via tissue segmentation [1] and cell density in lymphocyte-rich area [2] impacts prognosis and treatment in hepatocellular carcinoma (HCC). Few biomarker models exist to prognosticate patients with HCC via the automated analysis of TME at the cellular level. Methods: Clinical outcomes data and histopathology images of 351 patients with HCC were obtained from TCGA. We advanced a deep learning-based algorithm to analyze the tumor volume and spatial distribution of nuclei

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Samani, Zahra Riahi, Drew Parker, Ronald Wolf, Steven Brem, and Ragini Verma. "BRMP-04. AI-based biomarker of the peritumoral region using tissue microstructure." Neuro-Oncology 23, Supplement_6 (2021): vi223—vi224. http://dx.doi.org/10.1093/neuonc/noab196.897.

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Abstract PURPOSE Glioblastomas, the most common malignant brain tumor [BS1], infiltrate into peritumoral brain structures, making clinical management challenging. An unmet need is to develop a biomarker that reliably characterize infiltration in the peritumoral region, where surgical biopsy or resection may be hazardous. Diffusion tensor imaging (DTI) with multicompartment modeling can characterize extracellular free water, providing unique information of the tissue microstructure that is able to capture this heterogeneity. We propose a novel biomarker based on peritumoral tissue microstructur

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Lee, Jeong Won, Sung Yong Kim, Sun Wook Han, et al. "Clinical Significance of Peritumoral Adipose Tissue PET/CT Imaging Features for Predicting Axillary Lymph Node Metastasis in Patients with Breast Cancer." Journal of Personalized Medicine 11, no. 10 (2021): 1029. http://dx.doi.org/10.3390/jpm11101029.

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We investigated whether textural parameters of peritumoral breast adipose tissue (AT) based on F-18 fluorodeoxyglucose (FDG) PET/CT could predict axillary lymph node metastasis in patients with breast cancer. A total of 326 breast cancer patients with preoperative FDG PET/CT were retrospectively enrolled. PET/CT images were visually assessed and the maximum FDG uptake of axillary lymph nodes (LN SUVmax) was measured. From peritumoral breast AT, 38 textural features of PET imaging were extracted. The diagnostic ability of PET based on visual analysis, LN SUVmax, and textural features of peritum

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Simińska, Donata, Klaudyna Kojder, Dariusz Jeżewski та ін. "Estrogen α and β Receptor Expression in the Various Regions of Resected Glioblastoma Multiforme Tumors and in an In Vitro Model". International Journal of Molecular Sciences 25, № 7 (2024): 4130. http://dx.doi.org/10.3390/ijms25074130.

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Glioblastoma multiforme (GBM) is a malignant tumor with a higher prevalence in men and a higher survival rate in transmenopausal women. It exhibits distinct areas influenced by changing environmental conditions. This study examines how these areas differ in the levels of estrogen receptors (ERs) which play an important role in the development and progression of many cancers, and whose expression levels are often correlated with patient survival. This study utilized two research models: an in vitro model employing the U87 cell line and a second model involving tumors resected from patients (inc

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Chen, Ran-Chou, Chao-Shiang Li, Jiunn-Ming Lii, Wei-Tsung Chen, and Hsing-Yang Tu. "Peritumoral fat-spared area is well correlated with the presence of temporal peritumoral enhancement in hepatic hemangioma in fatty liver." Journal of Magnetic Resonance Imaging 22, no. 1 (2005): 86–91. http://dx.doi.org/10.1002/jmri.20343.

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Dzhenkova, E. A., E. A. Mirzoyan, A. B. Sagakyants, et al. "Evaluation of Toll-like receptors expression in terms of colon cancer." Research and Practical Medicine Journal 9, no. 4 (2022): 63–71. http://dx.doi.org/10.17709/2410-1893-2022-9-4-6.

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Purpose of the study. To evaluate the number of cells with the CD45+/- phenotype expressing Toll-like receptors (TLRs) in tissues of the tumor, peritumoral area and resection line tissues in colon cancer (CC) with various tumor locations.Materials and methods. The study included 50 patients with CC. All patients underwent surgery as the primary treatment, and tissue material was collected from the patients. Expression of TLRs (2, 3, 4, 8, 9) on CD45+, CD45- cell populations was determined by flow cytometry in cell suspensions obtained from tissues of the tumor, peritumoral area (1–3 cm from th

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Cepeda, Santiago, Luigi Luppino, Marek Wodsinski, et al. "NIMG-45. EXTERNAL EVALUATION OF A MACHINE LEARNING MODEL EMPLOYING RADIOMICS TO IDENTIFY REGIONS OF LOCAL RECURRENCE IN GLIOBLASTOMA FROM POSTOPERATIVE MRI." Neuro-Oncology 25, Supplement_5 (2023): v195—v196. http://dx.doi.org/10.1093/neuonc/noad179.0741.

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Abstract The standard surgical goal for operable glioblastomas worldwide is the complete excision of the enhancing tumor. Nevertheless, the peritumoral region harbors infiltrating cells leading to recurrence. Our study aims to evaluate a predictive model designed to predict potential regions of recurrence using voxel-based radiomics analysis on postoperative magnetic resonance imaging (MRI). This retrospective, multi-institutional study involved glioblastoma patients who had undergone complete resection. The training cohort comprised 49 patients from two Spanish institutions, with model evalua

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Simińska, Donata, Jan Korbecki, Klaudyna Kojder, et al. "Androgen Receptor Expression in the Various Regions of Resected Glioblastoma Multiforme Tumors and in an In Vitro Model." International Journal of Molecular Sciences 23, no. 21 (2022): 13004. http://dx.doi.org/10.3390/ijms232113004.

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Glioblastoma multiforme (GBM) is a malignant glioma, difficult to detect and with the lowest survival rates among gliomas. Its greater incidence among men and its higher survival rate among premenopausal women suggest that it may be associated with the levels of androgens. As androgens stimulate the androgen receptor (AR), which acts as a transcription factor, the aim of this study was the investigate the role of AR in the progression of GBM. The study was conducted on tissues collected from three regions of GBM tumors (tumor core, enhancing tumor region, and peritumoral area). In addition, an

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Granata, Vincenza, Roberta Fusco, Mario Sansone, et al. "Magnetic resonance imaging in the assessment of pancreatic cancer with quantitative parameter extraction by means of dynamic contrast-enhanced magnetic resonance imaging, diffusion kurtosis imaging and intravoxel incoherent motion diffusion-weighted imaging." Therapeutic Advances in Gastroenterology 13 (January 2020): 175628481988505. http://dx.doi.org/10.1177/1756284819885052.

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Background: Despite great technical advances in imaging, such as multidetector computed tomography and magnetic resonance imaging (MRI), diagnosing pancreatic solid lesions correctly remains challenging, due to overlapping imaging features with benign lesions. We wanted to evaluate functional MRI to differentiate pancreatic tumors, peritumoral inflammatory tissue, and normal pancreatic parenchyma by means of dynamic contrast-enhanced MRI (DCE-MRI)-, diffusion kurtosis imaging (DKI)-, and intravoxel incoherent motion model (IVIM) diffusion-weighted imaging (DWI)-derived parameters. Methods: We

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Zhong, Shiling, Fan Wang, Zhiying Wang, Minghui Zhou, Chunli Li, and Jiandong Yin. "Multiregional Radiomic Signatures Based on Functional Parametric Maps from DCE-MRI for Preoperative Identification of Estrogen Receptor and Progesterone Receptor Status in Breast Cancer." Diagnostics 12, no. 10 (2022): 2558. http://dx.doi.org/10.3390/diagnostics12102558.

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Radiomics based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has been used for breast estrogen receptor (ER) and progesterone receptor (PR) status evaluation. However, the radiomic features of peritumoral regions were not thoroughly analyzed. This study aimed to establish and validate the multiregional radiomic signatures (RSs) for the preoperative identification of the ER and PR status in breast cancer. A total of 443 patients with breast cancer were divided into training (n = 356) and validation (n = 87) sets. Radiomic features were extracted from intra- and peritumoral

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Yang, Wenbin, Sen Jiang, Jianbang Lin, and Yangkang Li. "CT findings predict survival of patients with peripheral T cell lymphoma: a preliminary study." Radiology and Oncology 53, no. 1 (2019): 31–38. http://dx.doi.org/10.2478/raon-2019-0005.

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Abstract Background Peripheral T-cell lymphoma (PTCL) is an uncommon disease with poor clinical outcomes. Radiological reports on the survival of patients with PTCL are scarce. The purpose of this study is to investigate the prognostic value of CT findings to predict clinical outcomes in fifty-one patients with histologically proven PTCL. Patients and methods The clinical data and CT images of all patients were retrospectively reviewed. CT features including number of involvement sites, lesion size, shape, margin, density, peritumoral invasion, intratumoral necrosis, lymph node involvement, an

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Bova, F. S., O. I. Kit, A. Yu Maksimov, and N. S. Karnaukhov. "Modification of biochemical recurrence risk in patients with localized prostate cancer after radical prostatectomy with combined histomorphological changes in the peritumoral zone." Kazan medical journal 99, no. 3 (2018): 408–15. http://dx.doi.org/10.17816/kmj2018-408.

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Aim. To assess the prognostic significance of histopathological processes in the peritumoral zone with respect to the risk of biochemical recurrence in patients with localized prostate cancer after radical prostatectomy. Methods. Histomorphological studies were conducted in the perifocal area of surgical tissue samples from 309 patients with localized prostate cancer (T1c-2cN0M0) after a radical surgery using light microscopy. Four groups of patients were identified depending on the risk of recurrence. Enzyme immunoassay was used to determine the concentration of prostate-specific antigen in t

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Sun, Xiaojun, Peipei Pang, Lin Lou, Qi Feng, Zhongxiang Ding, and Jian Zhou. "Radiomic prediction models for the level of Ki-67 and p53 in glioma." Journal of International Medical Research 48, no. 5 (2020): 030006052091446. http://dx.doi.org/10.1177/0300060520914466.

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Objective To identify glioma radiomic features associated with proliferation-related Ki-67 antigen and cellular tumour antigen p53 levels, common immunohistochemical markers for differentiating benign from malignant tumours, and to generate radiomic prediction models. Methods Patients with glioma, who were scanned before therapy using standard brain magnetic resonance imaging (MRI) protocols on T1 and T2 weighted imaging, were included. For each patient, regions-of-interest (ROI) were drawn based on tumour and peritumoral areas (5/10/15/20 mm), and features were identified using feature calcul

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Zhao, Jian-Lan, Bo Tan, Gong Chen, et al. "Hypoxia-Induced Glioma-Derived Exosomal miRNA-199a-3p Promotes Ischemic Injury of Peritumoral Neurons by Inhibiting the mTOR Pathway." Oxidative Medicine and Cellular Longevity 2020 (October 13, 2020): 1–12. http://dx.doi.org/10.1155/2020/5609637.

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The underlying molecular mechanisms that the hypoxic microenvironment could aggravate neuronal injury are still not clear. In this study, we hypothesized that the exosomes, exosomal miRNAs, and the mTOR signaling pathway might be involved in hypoxic peritumoral neuronal injury in glioma. Multimodal radiological images, HE, and HIF-1α staining of high-grade glioma (HGG) samples revealed that the peritumoral hypoxic area overlapped with the cytotoxic edema region and directly contacted with normal neurons. In either direct or indirect coculture system, hypoxia could promote normal mouse hippocam

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Parlak, Ayşe Eda, and Burak Yangoz. "The Significance of Relative Cerebral Blood Volume Index in Discriminating Glial Tumors from Brain Metastasis Using Perfusion Magnetic Resonance Imaging." Diagnostics 15, no. 11 (2025): 1324. https://doi.org/10.3390/diagnostics15111324.

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Background/Objectives: The accurate diagnosis and classification of brain tumors are critical for appropriate treatment planning and patient management. We evaluated the effectiveness of perfusion in differentiating glial tumors from metastases using dynamic susceptibility-weighted contrast enhanced perfusion MRI (DSC-MRI) Methods: A total of 95 consecutive patients with pathological diagnoses of brain tumors who underwent perfusion MRI between July 2021 and March 2023 were retrospectively recruited. Conventional and perfusion MRI were evaluated, and tumoral and peritumoral relative cerebral b

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Surhonne, Sharmila P., Sahithi Tadi, Shushan S. Jayker, and Jyothi R. Kaluva. "Spectrum of Lesions in Peritumoral Area in Association with Carcinoma of Breast." Journal of Medical Sciences 5, no. 3 (2019): 63–66. http://dx.doi.org/10.5005/jp-journals-10045-00130.

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Tamura, Ryota, Kentaro Ohara, Hikaru Sasaki, et al. "Difference in Immunosuppressive Cells Between Peritumoral Area and Tumor Core in Glioblastoma." World Neurosurgery 120 (December 2018): e601-e610. http://dx.doi.org/10.1016/j.wneu.2018.08.133.

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Kousi, E., I. Tsougos, E. Tsolaki, et al. "Spectroscopic Evaluation of Glioma Grading at 3T: The Combined Role of Short and Long TE." Scientific World Journal 2012 (2012): 1–11. http://dx.doi.org/10.1100/2012/546171.

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Purpose. To evaluate the diagnostic value of 3T1H-MRS in grading cerebral gliomas using short and long echo times.Methods. 1H-MRS was performed on 71 patients with untreated cerebral gliomas. Metabolite ratios of NAA/Cr, Cho/Cr, Cho/NAA, and mI/Cr were calculated for short and long TE and compared between low and high grade gliomas. Lipids were qualitatively evaluated. ROC analysis was performed to obtain the cut-off values for the metabolic ratios presenting statistical difference between the two glioma grades.Results. Intratumoral Cho/Cr at both TEs and long TE Cho/NAA were significantly dif

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Greco, Federico, Luigi Giuseppe Quarta, Aldo Carnevale, et al. "Subcutaneous Adipose Tissue Reduction in Patients with Clear Cell Renal Cell Carcinoma and Peritumoral Collateral Vessels: A Retrospective Observational Study." Applied Sciences 11, no. 13 (2021): 6076. http://dx.doi.org/10.3390/app11136076.

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Background: peritumoral collateral vessels adjacent to renal cell carcinoma (RCC) can be encountered in clinical practice. Cancer cachexia is defined as a decrease of adipose and skeletal muscle tissues. In this study we evaluated, using a quantitative CT imaging-based approach, the distribution of abdominal adipose tissue in clear cell RCC (ccRCC) male patients with and without collateral vessels. Methods: between November 2019 and February 2020, in this retrospective study we enrolled 106 ccRCC male Caucasian patients divided into two groups: a ccRCCa group without collateral vessels (n = 48

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Ghinda, Diana C., Yufei Yang, Shuai Wu, et al. "Personalized Multimodal Demarcation of Peritumoral Tissue in Glioma." JCO Precision Oncology, no. 4 (September 2020): 1128–40. http://dx.doi.org/10.1200/po.20.00115.

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PURPOSE Gliomas are life-threatening brain tumors, and the extent of surgical resection is one of the strongest influences on survival rate. However, the proper distinction of infiltrated tissue remains elusive. The aim of this study was to use multimodal analyses to demarcate peritumoral tissue (PT) from tumoral (TT) and healthy tissue (HT). METHODS A total of 40 patients with histologically confirmed glioma were recruited. We analyzed resting-state functional magnetic resonance imaging (rs-fMRI) using the voxel-based mean blood-oxygen-level-dependent (BOLD) signal and the corresponding struc

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Shiinoki, Takehiro, Koya Fujimoto, Yusuke Kawazoe, et al. "Predicting programmed death-ligand 1 expression level in non-small cell lung cancer using a combination of peritumoral and intratumoral radiomic features on computed tomography." Biomedical Physics & Engineering Express 8, no. 2 (2022): 025008. http://dx.doi.org/10.1088/2057-1976/ac4d43.

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Abstract In this study, we investigated the possibility of predicting expression levels of programmed death-ligand 1 (PD-L1) using radiomic features of intratumoral and peritumoral tumors on computed tomography (CT) images. We retrospectively analyzed 161 patients with non-small cell lung cancer. We extracted radiomic features for intratumoral and peritumoral regions on CT images. The null importance, least absolute shrinkage, and selection operator model were used to select the optimized feature subset to build the prediction models for the PD-L1 expression level. LightGBM with five-fold cros

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Dilek, Okan, Emin Demırel, Zeynel Abidin Tas, and Emre Bılgın. "Exploring the Role of Peritumoral Edema in Predicting Lung Cancer Subtypes Through T2-FLAIR Digital Subtraction Imaging of Metastatic Brain Tumors." Diagnostics 15, no. 10 (2025): 1283. https://doi.org/10.3390/diagnostics15101283.

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Background/Objectives: This study aimed to investigate whether small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC) can be distinguished based on radiomics data derived from T2-FLAIR digital subtraction images of the peritumoral edema region in patients with brain metastases. Methods: A total of 136 patients who underwent surgery for brain tumors, including 100 patients in the Pretreat-Metstobrain-MASKS dataset and 36 patients from our institution, were included in our study. Radiomic features were extracted from digitally subtracted T2-FLAIR images in the peritumoral edema are

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Komiyama, Kazuki, Keiya Iijima, Reika Kawabata-Iwakawa, et al. "Glioma facilitates the epileptic and tumor-suppressive gene expressions in the surrounding region." Scientific Reports 12, no. 1 (2022). http://dx.doi.org/10.1038/s41598-022-10753-4.

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AbstractPatients with glioma often demonstrate epilepsy. We previously found burst discharges in the peritumoral area in patients with malignant brain tumors during biopsy. Therefore, we hypothesized that the peritumoral area may possess an epileptic focus and that biological alterations in the peritumoral area may cause epileptic symptoms in patients with glioma. To test our hypothesis, we developed a rat model of glioma and characterized it at the cellular and molecular levels. We first labeled rat C6 glioma cells with tdTomato, a red fluorescent protein (C6-tdTomato), and implanted them int

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Komiyama, Kazuki, Keiya Iijima, Reika Kawabata-Iwakawa, et al. "Glioma facilitates the epileptic and tumor-suppressive gene expressions in the surrounding region." Scientific Reports 12, no. 1 (2022). http://dx.doi.org/10.1038/s41598-022-10753-4.

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AbstractPatients with glioma often demonstrate epilepsy. We previously found burst discharges in the peritumoral area in patients with malignant brain tumors during biopsy. Therefore, we hypothesized that the peritumoral area may possess an epileptic focus and that biological alterations in the peritumoral area may cause epileptic symptoms in patients with glioma. To test our hypothesis, we developed a rat model of glioma and characterized it at the cellular and molecular levels. We first labeled rat C6 glioma cells with tdTomato, a red fluorescent protein (C6-tdTomato), and implanted them int

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Wang, Fang, Ming Cheng, Binbin Du, et al. "Predicting microvascular invasion in small (≤ 5 cm) hepatocellular carcinomas using radiomics-based peritumoral analysis." Insights into Imaging 15, no. 1 (2024). http://dx.doi.org/10.1186/s13244-024-01649-0.

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Abstract Objective We assessed the predictive capacity of computed tomography (CT)-enhanced radiomics models in determining microvascular invasion (MVI) for isolated hepatocellular carcinoma (HCC) ≤ 5 cm within peritumoral margins of 5 and 10 mm. Methods Radiomics software was used for feature extraction. We used the least absolute shrinkage and selection operator (LASSO) algorithm to establish an effective model to predict patients’ preoperative MVI status. Results The area under the curve (AUC) values in the validation sets for the 5- and 10-mm radiomics models concerning arterial tumors wer

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