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Fiorucci, Flavia. "Neither warriors, nor prophets : Peronist and Anti-Peronist intellectuals, 1945-1956." Thesis, University of London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397166.
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Lambkin, Gareth Robert. "The peroxin Pex19p of Yarrowia lipolytica." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ60450.pdf.
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Alvarado, Camilo. "Justicialist Party : Peronism and Institutionalization in Argentina." Thesis, Stockholms universitet, Romanska och klassiska institutionen, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-114455.
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This study aims at examining the level of institutionalization of the argentine party system as well as the Justicialist party. The paper presents two parallel analyses on the argentine party system and the Justicialist Party using two different perspectives on the concept of institutionalization. The first is a qualitative analysis using Mainwaring and Scully’s (1995) theory and operationalization of institutionalizations of party systems. This part analyses presidential and parliamentary electoral results in the period between 1995 and 2013. The second part of the study is a qualitative analysis of the Justicialist Party within the theoretical framework proposed by Randall and Svåsand (2002). This section analyses the origins of the party and its history throughout the 1900’s focusing on the character of the party, the relationship between the party as a whole and its leader(s) as well as the relationship between the party as a whole and its different factions.
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Lacey, Joanne. "Characterisation of a novel peroxin in Drosophila melanogaster." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/10694/.
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The peroxisome is an organelle conserved throughout eukaryotes, ranging from single-celled yeast to multi-cellular organisms including flies and humans. Peroxisome biogenesis involves formation of the peroxisomal membrane followed by import of luminal matrix proteins. Peroxisomes can be generated de novo from the endoplasmic reticulum (ER) or by fission of pre-existing peroxisomes. Proteins controlling peroxisome formation are collectively termed peroxins, and over 30 peroxins have now been identified. Peroxisomes depend on a diverse group of mechanisms to ensure the correct targeting of matrix and membrane proteins. However, the membrane biogenesis pathway is poorly characterised and currently limited to only three factors: Pex3, Pex16 and Pex19. Peroxisomal membrane proteins (PMPs) are targeted to peroxisomes by two distinct pathways; directly to peroxisomes or indirectly via the ER. Mutant peroxins are the cause of peroxisome biogenesis disorders in humans so it is essential to characterise their individual molecular mechanisms. Limited peroxisome research has been conducted using Drosophila melanogaster as a model system, but current studies indicate peroxins and cellular pathways are evolutionary conserved. Previously, our lab performed a genome-wide screen in Drosophila S2R+ cells to identify candidate peroxins. No mitochondrial derivative (NMD) was the top hit based on its knockdown phenotype of an import defect of PTS1 proteins. The AAA+ ATPase NMD is a conserved integral membrane protein that dually localises to peroxisomes and mitochondria. Loss of NMD, via RNAi or CRISPR, led to a lack of PMP import and mislocalisation of Pex3. NMD contains multiple sorting signals, displaying distribution between ER, peroxisomes and mitochondria. NMD was shown to interact directly with Pex16, a well-known peroxisomal membrane biogenesis factor, and that interaction is dependent on ATP binding. Further coimmunoprecipitation studies identified that NMD interacts with multiple peroxins as well as the ER translocon Sec61a. Overexpression of a dominant negative mutant of NMD defective in ATP hydrolysis, led to the mislocalisation of Pex3 and an import defect of PTS1 proteins, demonstrating ATPase activity is essential for function. Homologues of NMD exist in humans (ATAD1) and yeast (Msp1); but function in membrane assembly is not conserved. Analysis of the function of Msp1 revealed a genetic interaction with the yeast peroxin Pex25 in controlling peroxisome numbers. Collectively, the results suggest NMD is a novel component of the PMP import machinery in Drosophila, but that its role is not conserved in other model organisms.
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Oliver, Scott. "Capturing the imagination: Peronism and the micropolitics of desire." Thesis, University of Nottingham, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606266.
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This dissertation comprises an approach to an Argentine political movement - Peronism - whose principal intellectual attraction is in the wide array of evaluations it has produced, from both historians and adherents alike, an instability ultimately leading to the extraordinary massacre at Ezeiza in 1973 (and perhaps even the 'Dirty War' that engulfed Argentina upon Peran's death). Using the full repertoire of conceptual tools provided by Gilles Deleuze and Felix Guattari - the way in which power acts at the most intimate, micro-level; the way desire fuels the most murderous of social machines, above and below "Reason" - I will aim to chart the vicissitudes of the movement (and regime) as it emerged from the military junta that came to power in 1943. First, I will plot in Peran's military formation and its incipient connection to the authoritarian tendencies that characterized the regime, to which end we will call principally upon Tomas Eloy Martfnez's La novela de Peron. Thereafter, we will account for the complex causality behind the emergence of the movement, its means of holding together (explicitly rejecting ideological accounts), and its eventual coming-undone (removal from power in 1955). We shall not seek inherent properties, either in Peran the individual or the phenomena that bore his name. Both shall be considered as a "becoming" of always provisional, contingent entities (the greater or lesser effectuation, under concrete conditions, of certain abstract machines; in particular, the virtual absolute State: the Urstaat) produced by desire. Finally, in the light of the ' schizoanalytic' framework elaborated by Deleuze and Guattari, we will examine the hypothesis that Peronism's restoration in the 1970s constituted its fascist moment: not at all inevitable, or essential, but produced by a complex causal interaction of desire and power whose contours I hope to explain.
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Goebel, Thomas Michael. "Argentina's partisan past : nationalism, Peronism and historiography, 1955-76." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445121/.
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This PhD thesis is an inquiry into history as politics in Argentina from the overthrow of Peron to the military coup of 1976. Its main aim is to explain why and how a particular strand of nationalist historical writing (historical revisionism) conquered the public sphere in this period, so that by the 1970s its principal tenets had become almost common sense in the Argentines' understanding of their national past. For this purpose, the thesis contextualises the revisionist discourse in relation to, firstly, the intellectual field and, secondly, political developments, arguing that only a combination of cultural and political history allows us to account for the success of revisionism in influencing the collective historical consciousness. The principal primary sources on which the thesis relies are the publications of revisionists (both books and periodicals), militant periodicals, daily newspapers and institutional sources, in particular related to public education. Special emphasis is given to the conditions that underpinned the production and the public success of revisionist symbolic goods. In six chapters the thesis analyses the historical development of the relationship between the liberal and the nationalist view of history (1) the connection between contemporary debates about Peronism and the revisionist version of the past (2) the influence of Marxism (3) the cultural and political networks of revisionism (4) the Peronist appropriation of revisionist imagery (5) and the relationship between nationalist intellectuals and the state (6). From these points, the thesis derives broader conclusions about the relationship between politics, national identity and historical narratives by singling out the factors that contributed to such a strong politicisation of historiography under nationalist signs. Particularly stressed is the mutually reinforcing interplay between a profound crisis of political legitimacy, a fragile intellectual field and an uneven institutionalisation of historiography.
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Broussard, James Allen. "A champion for the disaffected: Ross Perot's 1992 presidential crusade." Diss., The University of Arizona, 1995. http://hdl.handle.net/10150/187056.
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In 1992, Ross Perot, billionaire entrepreneur from Texas, headed the most powerful independent presidential candidacy of the twentieth century, garnering nearly 19 percent of the popular vote. Perot's rhetoric demanded fundamental reform through a seemingly contradictory message calling for both individual responsibility and collective patriotism and sacrifice: corporate populism, a traditional, albeit profoundly paradoxical ideological appeal. Perot spoke of rekindling the "American Dream" for the next generation, whose prospects appeared bleak because of a post-Cold War credit crisis and withering of the United States' industrial base. He saw linkages between this crisis and a host of social problems, and advocated controversial solutions that made coalition-building difficult. Perot looked to his followers to develop consensuses on many issues of the day. Heading a "grassroots" movement organized from the top down, with disciples from all points on the ideological compass, however, Perot found consensus a rare commodity. As a result, his campaign lacked cohesion. Perot's methods, personality, and wealth raised disturbing questions about the future of representative democracy, but his unfolding campaign also highlighted shortcomings in American electoral institutions and processes. Perot's treatment by the press, for example, provides a case study of the mass-production of political portraits and the impact of those images. That so many citizens voted for a man often portrayed as a suspicious, morally rigid, unscrupulous, vengeful demagogue indicates how widely disaffection with American political institutions had spread. Tapping this discontent, Perot created the potential for a new kind of politics in the United States. He catalyzed discourse on policy issues like foreign trade, welfare reform, military policy, and Executive branch responsibility. He focused attention on chronic problems like the national debt, the annual budget deficit, and the insolvency of "entitlement" programs like Social Security and Medicare. His presence seems to have provoked an unusually high turnout on election day. He helped pioneer a new era of direct dialog between candidates and citizens through the use of interactive and electronic media. Finally, Perot's candidacy symbolizes the emergence of a new centrist political movement--a force which in 1994 began to dramatically reshape the American political landscape.
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Cyr, Normand. "Role of «Leishmania donovani» peroxin 14 in glycosomal import machinery." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114123.
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Peroxisomes are organelles found in eukaryotic cells where several oxidative processes take place. Enzymes destined for the peroxisome generally contain either a C-terminal or a N-terminal peroxisomal targeting signal, named PTS1 and PTS2 respectively. These signals are cytosolically recognized by their correspondent receptors PEX5 and PEX7 prior to being recruited at the surface of the peroxisomal membrane where the complex docks onto PEX14. Then, enzymes are transported in a natively folded fashion inside the organelle where they are released. In trypanosomatids, other metabolic pathways, including glycolysis, are also segregated in the organelle, which has been renamed the glycosome to better reflect its purpose. To gain a better understanding about this transport and translocation machinery that exist in Leishmania donovani, we have first looked at the quaternary structure of the docking protein LdPEX14, and the implication of several domains on the protein using various biochemical and biophysical techniques. Using gel permeation chromatography, analytical ultracentrifugation and chemical cross-linking, we observed that LdPEX14 was forming large oligomeric structures of varying sized both in solution and within the parasite. By domain mapping studies, we identified three domains on LdPEX14, the LdPEX5 binding site, an hydrophobic region and a predicted leucine zipper, to all being implicated in the formation of such oligomer. Moreover, we investigated the structural changes that take place on LdPEX14 upon binding LdPEX5. Both isothermal titration calorimetry and fluorescence spectroscopy revealed that the hydrophobic region of LdPEX14 became more exposed to the solvent upon attachment to LdPEX5. Likewise, circular dichroism studies demonstrated that a portion of LdPEX14 was losing some secondary structure upon binding to LdPEX5, which was also linked to the formation of a more compact complex based on analytical ultracentrifugation experiments. We hypothesized that these structural features and conformational changes could be link to the formation of pore that will facilitate the translocation of proteins targeted to the glycosome. Such oligmeric structure was also confirmed by immunoelectron microscopy using parasite sections. LdPEX14 clusters adopted round, rosette-like shapes of about 30-40 nm in diameter and were found mainly at the surface of the glycosomal membrane. A lipidomic investigation of the glycosomal membrane from Leishmania donovani revealed the presence of very long chain polyunsaturated fatty acids, and of a relatively high proportion of the negatively charged phospholipids phosphatidyl glycerol and phosphatidyl inositol. These phospholipids appeared to be essential for a proper membrane attachment of LdPEX14. Domain mapping showed that the hydrophobic region of LdPEX14, comprised between the amino acids 149 and 179, was essential for proper binding to liposomes mimicking the glycosomal membrane phospholipid composition. Bioinformatics analysis revealed that this region also contains a important cluster of basic residues which we hypothesize could be involved in the initial membrane attachment. A further investigation using fluorescence spectroscopy showed that this region was sufficient for binding to liposomes mimicking the glycosomal and was penetrating the lipid bilayer. By performing a dye leakage assay from the liposomes, we observed that ldpex14 (120-200), a peptide comprising the hydrophobic region of LdPEX14, was capable of perforating the liposomes and cause a leakage of the encapsulated dye. Finally, using density flotation assays with liposomes, we demonstrated that not only LdPEX14 was recruting LdPEX5 at the surface of the bilayer, but that LdPEX5, upon attachment, was adopting a conformation similar to integral membrane proteins. This observation tends to suggest that LdPEX5 could also be implicated in the pore formation for the translocation of glycosomal enzymes.Le peroxysome est un organite où plusieurs procédés oxydatifs prennent place. Les enzymes destinés au peroxysome contiennent un signal peptidique soit à leur terminal C ou N, nommés PTS1 ou PTS2 respectivement. Ce signal est reconnu dans le cytoplasme par son récepteur correspondant (PEX5-PTS1, PEX7-PTS2) où le complexe PTS1-PEX5/PEX7-PTS2 s'arrime à PEX14. Ensuite, les enzymes sont transportés sous leur forme native à l'intérieur de l'organite où ils sont relâchés de leur récepteur. Chez les trypanosomatides, plusieurs voies métaboliques, incluant la glycolyse, sont ségrégées dans l'organite (renommé le glycosome pour refléter la présence d'enzymes glycolytiques). Afin d'obtenir une meilleure compréhension à propos du transport et de la machinerie de translocation existant chez Leishmania donovani, nous avons d'abord déterminé la structure quaternaire, en utilisant diverses techniques biochimiques et biophysiques. En faisant usage de la chromatographie d'exclusion stérique, de l'ultracentrifugation analytique et de la réticulation chimique, nous avons observé que LdPEX14 forme de larges structures oligomériques de taille variable en solution et dans le parasite. En excluant différents domaines sur LdPEX14, nous avons identifiés trois domaines impliqués dans la formation de ces oligomères: (i) le site d'attachement à LdPEX5, (ii) une région hydrophobe et (iii) une glissière à leucine. De plus, nous avons recherché quels étaient les changements structuraux prenant place sur LdPEX14 lors de l'attachement à LdPEX5. En utilisant la calorimétrie isotherme à titration et la spectroscopie de fluorescence, nous avons découvert que la région hydrophobe de LdPEX14 devenait exposée au solvant lorsque LdPEX5 s'y attachait. De plus, des études de dichroïsme circulaire ont démontré qu'une portion de LdPEX14 perdait une partie de sa structure secondaire lors de l'attachement à LdPEX5, ce qui fut aussi relié à la formation d'un complexe LdPEX14-LdPEX5 plus compact, tel qu'illustré par ultracentrifugation analytique. Nous avons donc supposé que ces propriétés structurelles et ces changements de conformation seraient liés à la formation d'un pore qui faciliterait la translocation des protéines dirigées vers le glycosome. La structure oligomérique de LdPEX14 fut aussi confirmée par microscopie immuno-électronique en utilisant des sections de parasite. La protéine LdPEX14 s'assemblait en grappes formant des rosettes d'environ 30 nm de diamètre, principalement à la surface extérieure de la membrane du glycosome. Une étude lipidomique de la membrane du glycosome a révélé une proportion importante de phosphatidyl glycérol et de phosphatidyl inositol, phospholipides chargés négativement. Ces derniers sembleraient essentiels pour l'attachement de LdPEX14 à la membrane du glycosome. Nous avons ensuite démontré que la région hydrophobe de LdPEX14, comprise entre les acides aminés 149 et 179, était essentielle pour l'attachement à des liposomes imitant la membrane du glycosome. Une investigation plus poussée, utilisant la spectroscopie de fluorescence, a montré que cette région était suffisante pour l'attachement à des liposomes imitant la membrane du glycosome, et était de plus capable de pénétrer cette membrane. En effectuant un test d'écoulement de colorant fluorescent encapsulé dans les liposomes, nous avons observé que ldpex14(120-200), un peptide comprenant la région hydrophobe de LdPEX14, était capable de perforer les liposomes et causer un écoulement du colorant fluorescent. Finalement, en utilisant des tests de flottaison par densité différentielle avec des liposomes, nous avons démontré que non seulement LdPEX14 est capable de recruter LdPEX5 à la surface des liposomes, mais que LdPEX5 finissaient par adopter une conformation semblable à une protéine membranaire intégrale. Cette observation tend à suggérer que LdPEX5 pour elle aussi être impliquée dans la formation d'un pore pour la translocation d'enzymes destinés pour le glycosome.
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Guder, Philipp [Verfasser]. "Strukturelle und funktionelle Charakterisierung des humanen Peroxins PEX26 / Philipp Guder." Hamburg : Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky, 2020. http://d-nb.info/1234400456/34.
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Groppo, Alejandro J. "The two princes : a comparative study of the emergence of Peron in Argentina and Vargas in Brazil." Thesis, University of Essex, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268738.
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Davidsen, Amanda. "Biophysical investigations of structural features and interactions of «Leishmania donovani» Peroxin 5." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=123260.
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Parasites of the genus Leishmania cause a broad array of diseases, collectively termed leishmaniasis. These diseases range in morbidity; the cutaneous form is typically self healing, while the mucocutaneous and visceral manifestations require chemotherapeutic intervention to avoid lethality. At present there is no vaccine, and current methods of chemotherapeutic intervention have severe drawbacks, together creating a dire need for new options to combat these destructive diseases. An organelle within the parasite, the glycosome, has been identified as an attractive drug target. The glycosome compartmentalizes several enzymes from important biosynthetic and metabolic pathways, which has been shown to be necessary for the viability of the parasite. Although the organelle is structurally and evolutionarily related to peroxisomes of higher eukaryotes, the import machinery of the organelles differs significantly. The majority of proteins entering the glycosome contain a C-terminal PTS1 tri-peptide sequence, which is readily recognized and bound by the soluble cytosolic receptor LPEX5. The receptor binds PTS1 cargo in the cytosol, shuttling it to the glycosomal membrane where the protein interacts with LPEX14, a peripherally membrane bound protein. The interaction with LPEX14 at the glycosomal membrane, facilitated by several other biogenesis proteins, initiates the formation of a transient import pore. In this thesis research project the role of Leishmania donovani PEX5 (LdPEX5) in formation of this crucial import pore was analyzed. Using biophysical techniques, it was found that interaction of the receptor with a PTS1 did not cause major changes in secondary structure, although did provoke a conformational change in the protein, preceding and possibly facilitating its interactions with LdPEX14 at a glycosomal membrane. Using large unilamellar vesicles mimicking the glycosomal lipid composition, the domain of LdPEX5 necessary to interact with LdPEX14 was then narrowed to 268-302. Furthermore, using serial carbonate-urea extractions, the domain identified to be necessary for interaction with LdPEX14 at a glycosomal mimetic was also found to insert into the liposomal membrane, implying that the insertion of LdPEX14 into the glycosomal membrane could be drawing LdPEX5 into the membrane as part of pore formation. In conclusion, this study has implicated LdPEX5 in having a central role in formation of the transient glycosomal import pore.Les parasites du genre Leishmania provoquent un large éventail de maladies, appelées collectivement leishmanioses. Ces maladies varient en termes de morbidité ; la forme cutanée se conclut généralement par une auto-guérison, alors que les manifestations cutanéo-muqueuses et viscérales nécessitent une intervention chimiothérapeutique pour éviter le décès. À l'heure actuelle, il n'existe aucun vaccin, et les méthodes actuelles d'intervention chimiothérapeutique présentent de graves conséquences. Il existe aujourd'hui un besoin urgent de trouver de nouvelles options pour lutter contre ces maladies destructrices. Un organite dans le parasite, le glycosome, a été identifié comme une cible thérapeutique intéressante. Le glycosome compartimente plusieurs enzymes de biosynthèses et voies métaboliques importantes; il a été prouvé que cet organite est nécessaire pour assurer la viabilité du parasite. Bien que l'organite soit structurellement et évolutivement lié aux peroxysomes des eucaryotes supérieurs, le mécanisme d'importation des organites diffère sensiblement. La majorité des protéines entrant dans le glycosome contient une séquence tri-peptide PTS1 C-terminal, qui est facilement reconnue et liée par le récepteur cytosolique soluble LPEX5. Le récepteur se lie au cargo PTS1 dans le cytosol, le conduisant vers la membrane glycosomale où la protéine interagit avec LPEX14, une protéine liée à la membrane périphérique. L'interaction avec LPEX14 au niveau de la membrane glycosomale, facilitée par plusieurs autres protéines de biogenèse, initie la formation d'un pore d'importation transitoire. Dans ce projet de thèse, le rôle de PEX5 dans la formation de ce pore d'importations essentiel a été analysé chez Leishmania donovani. En utilisant des techniques biophysiques, il a été constaté que l'interaction du récepteur avec un PTS1 n'a pas causé de changements majeurs dans la structure secondaire, bien qu'elle ait provoqué un changement de conformation de la protéine, précédant et éventuellement facilitant ses interactions avec LdPEX14 à une membrane glycosomale. Grâce à l'utilisation de grandes vésicules unilamellaires mimant la composition lipidique glycosomale, le domaine de LdPEX5 nécessaire pour interagir avec LdPEX14 fut ramené à 268-302. En outre, en utilisant des extractions carbonate-urée en série, il a été prouvé que le domaine identifié comme étant nécessaire pour l'interaction avec LdPEX14 au mimétique glycosomal, s'insère dans la membrane liposomale. De ce fait, l'insertion de LdPEX14 dans la membrane glycosomale pourrait tirer LdPEX5 dans la membrane dans le contexte de la formation de pores. En conclusion, cette étude a démontré que LdPEX5 possède un rôle central dans la formation du pore d'importation glycosomale transitoire.
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Schäuble, Chloe Sarah. "Geographic variation in the widespread Australian frogs Limnodynastes tasmaniensis and L. peronii /." [St. Lucia, Qld.], 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16936.pdf.
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Bell, Lawrence D. "The Jews and Peron : communal politics and national identity in Peronist Argentina, 1946-1955 /." Columbus, OH : Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1039034580.
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Thesis (Ph. D.)--Ohio State University, 2002.Title from first page of PDF file. Document formatted into pages; contains ix, 332 p. Includes abstract and vita. Advisor: Kenneth J. Andrien, Dept. of History. Includes bibliographical references (p. 310-332).
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Nyisztor, Michael. "The Leishmania donovani peroxin 14 N-terminal region is important for glycosomal localization." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100200.
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Glycosomes are subcellular organelles that are evolutionarily related to the peroxisomes of higher eukaryotes. The Leishmania glycosome performs various metabolic processes that are essential for the survival of these parasites, such as the glycolytic process. Proteins that are destined for import into the glycosome interact selectively with specific cytosolic receptors peroxin 5(PEX5) or PEX7. The PEX5-protein complex migrates toward the glycosomal membrane where it interacts with PEX14, a vital step for protein important into the glycosome.This project investigated the interaction mechanism of Leishmania donovani PEX14 with the glycosomal membrane. The regions responsible for PEX14 interaction with the glycosomal membrane are established in higher eukaryotes. LdPEX14 is poorly conserved with respect to the other PEX14 homologues. In Leishmania the interaction of LdPEX14 with the glycsomal membrane has been shown to be unique in terms of its lack of insertion in the glycosomal membrane. Using LdPEX14 mutants it was determined that the first 63 amino acids are important for the interaction of LdPEX14 with the glycosomal membrane. Results further suggest that LdPEX14 is a homopolymer forming a complex of 20S in size which is vital for the proper functioning of the glycosome.
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Sillner, Sarah [Verfasser]. "Synthesewege zu neuen Malariatherapeutika: Peroxid-Dyaden aus Artemisininderivaten und Terpen-Endoperoxiden / Sarah Sillner." München : Verlag Dr. Hut, 2014. http://d-nb.info/1064559972/34.
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Castagnola, G. H. "Body of evidence : Juan Domingo Peron's discourse during his political exile (1955-1972)." Thesis, University of Essex, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369357.
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Drake, Peter. "The first genome-wide screen for animal peroxins using RNAi in Drosophila melanogaster." Thesis, University of Sheffield, 2013. http://etheses.whiterose.ac.uk/3777/.
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Peroxisomes are spherical, membrane-bound organelles found ubiquitously in Eukaryotes. They have very important metabolic functions, the loss of which has severely morbid consequences for human patients. Genes involved in peroxisome biosynthesis are evolutionarily conserved. There are now more than thirty known proteins (peroxins) involved in peroxisome biosynthesis (including peroxisomal matrix protein import, peroxisome multiplication and inheritance). Higher organisms are expected to have many more peroxins than yeasts and plants that have well established peroxisome families. Yet fewer peroxins are known of and consequently their interactions are poorly understood. Recent technological advances in RNA interference (RNAi) and high-throughput screening have meant entire organisms can now be screened in negative gene function assays. The inauguration in 2010 of the Sheffield RNAi Screening Facility (SRSF) has meant that an on-site facility at Sheffield University can facilitate genome-wide screening of Drosophila melanogaster, an organism for which technologies into genetic manipulation are well established. The use of cell-culture and high-content, automated epifluorescence microscopy means that D. melanogaster cells can be screened for peroxins using well-established fluorescence assays. Two genome-wide screens were performed on S2R+ cells in an attempt to uncover novel peroxins in fruitflies which may elucidate further peroxisomes in mammals. Both screens used fluorescent peroxisomal matrix markers. The first was transfected transiently and the second stably, improving the expression profile in the cellular population. A small number of aberrant phenotypes were quickly identified and many knockdown phenotypes had a milder presentation. The most statistically significant aberrant candidates were chosen to be compiled into a custom designed microtitre plate. We made many copies of this and we repeated the assay in triplicate. We were able to identify 3 newly aberrant phenotypes of knockdown of which 2 appear to effect peroxisomes directly. One of these appears to behave in a PEX16 like manner and we decided to investigate this further.
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Peroni, Leonardo. "Resíduos renováveis na produção de mudas de Eucalyptus grandis / Leonardo Peroni." Universidade Federal do Espírito Santo, 2012. http://repositorio.ufes.br/handle/10/5823.
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Leonardo Peroni.pdf: 823023 bytes, checksum: 025aac3b955d96c5a6c8ecbe8978f8ae (MD5)
Previous issue date: 2012-02-29This study aimed to test the use of sewage sludge and renewable organic waste in the composition of substrates for the production of Eucalyptus grandis W. Hill ex Maiden seedlings. The seedlings were grown in the Forest Nursery of the of Forest and Wood Department of the Agricultural Sciences Center from the Federal University of Espírito Santo, in the municipality of Alegre, in tubes with a capacity of 280 cm3, containing different combinations of substrates. After 90 days, the morphological and nutritional characteristics were evaluated. The used substrates were made from different combinations of sewage sludge with renewable vegetable waste such as coconut fiber, fresh coffee straw, organic compost (manure + fresh coffee straw) and fresh rice husk, in proportions of 100:0, 80:20, 60:40, 40:60 and 20:80 (sewage sludge : crop residues), and a control, consisting of a commercial substrate, totaling 18 treatments with six replicates of four plants each. Physical analysis of all the formulated substrates demonstrated that they showed low density, with a tendency to increase according to the rise of sewage sludge proportions in their composition. It was observed in the treatments containing higher proportions of sludge an increased porosity. There was a reduction of macroporosity values in treatments containing over 60% of coconut fiber and over 40% of fresh rice husk in the substrates composition. Most treatments showed appropriate microporosity, and in general, the microporosity corresponded to a higher percentage of porosity distribution in all treatments. The treatments composed of waste such as fresh coffee straw and fresh rice husks allowed a greater drain to the substrate, which provided more room for airing and a lower amount of water easily available. Chemical analysis of substrates revealed a low pH, between 4.0 and 5.7, for all treatments and adequate CTC for most of them. The use of increasing proportions of coconut fiber, fresh rice husk and fresh coffee straw promoted additions of K to the substrate and reduction of the Ca available. The use of growing proportions of sewage sludge promoted an increase of the total content of soluble salts of the substrate. The treatments containing organic compound in the composition provided the best developments of the seedlings morphological characteristics. Most treatments had proper foliar levels of N, Ca, S, Mn and B, high levels of P and Cu and low concentrations of K, Mg, Fe and Zn. The combination of renewable vegetable organic waste and sewage sludge provided significant differences in terms of seedling growth, compared to the commercial substrate commonly used, demonstrating the importance of evaluating the potential of each residue as a component of the substrate before employing it commercially, since some materials may provide a less impressive seedling development
Este estudo teve como objetivo testar a utilização de lodo de esgoto e resíduos orgânicos renováveis na composição de substratos para a produção de mudas de Eucalyptus grandis W. Hill ex Maiden. As mudas foram produzidas no Viveiro Florestal do Departamento de Ciências Florestais e da Madeira do Centro de Ciências Agrárias da UFES, no município de Alegre, em tubetes de 280 cm3 de capacidade, contendo diferentes combinações de substratos. Após 90 dias foram avaliadas as características morfológicas e nutricionais. Os substratos utilizados foram formulados a partir de diferentes combinações de lodo de esgoto com resíduos renováveis de origem vegetal, tais como: fibra de coco, palha de café in natura, composto orgânico (esterco bovino + palha de café in natura) e casca de arroz in natura, nas proporções de 100:0, 80:20, 60:40, 40:60 e 20:80 (lodo de esgoto:resíduo vegetal), e uma testemunha, constituída por substrato comercial, totalizando 18 tratamentos, com seis repetições de quatro plantas cada. A análise física de todos os substratos formulados demonstrou que os mesmos apresentaram baixa densidade, com tendência de aumento conforme o aumento das proporções de lodo de esgoto na sua composição. Observou-se nos tratamentos com maiores proporções de lodo de esgoto um aumento da porosidade total. Houve redução da macroporosidade em tratamentos que continham valores acima de 60% de fibra de coco e casca de arroz in natura acima de 40% na composição de substratos. A maioria dos tratamentos apresentaram microporosidade adequada, e de forma geral, a microporosidade correspondeu a uma maior proporção da distribuição da porosidade em todos os tratamentos. Os tratamentos compostos por resíduos como a palha de café in natura e a casca de arroz in natura possibilitaram uma maior drenagem ao substrato, o que proporcionou maior espaço de aeração e menor quantidade de água facilmente disponível. A análise química dos substratos revelou um pH baixo, entre 4,0 e 5,7, para todos os tratamentos e CTC adequada para a maioria deles. A utilização de proporções crescentes de fibra de coco, casca de arroz in natura e palha de café in natura promoveu acréscimos de K ao substrato e redução nos teores de Ca disponível. A utilização de proporções crescentes de lodo de esgoto promoveu aumento do teor total de sais solúveis do substrato. Os tratamentos que continham composto orgânico em sua composição proporcionaram os melhores desenvolvimentos das características morfológicas da mudas. A maioria dos tratamentos apresentou adequados teores foliares de N, Ca, S, Mn e B, altos teores de P e Cu e baixos teores de K, Mg, Fe e Zn. A combinação de resíduos orgânicos renováveis de origem vegetal e lodo de esgoto proporcionaram diferenças importantes em termos de crescimento das mudas, em relação ao substrato comercial comumente utilizado, demonstrando a importância de se avaliar o potencial de cada resíduo como componente de substrato antes de empregá-lo comercialmente, visto que alguns materiais podem proporcionar um desenvolvimento de mudas aquém do desejado
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Borges, Juliana Perosso [UNESP]. "Alteração da expressão de sFAS e sFASL na leishmaniose voisceral canina: Juliana Perosso Borges. -." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/124435.
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000836107.pdf: 635760 bytes, checksum: ec2d485fda10942342f695f3a95c00d4 (MD5)A leishmaniose visceral (LV) é causada por parasitas intracelulares do gênero Leishmania que afeta humanos e várias espécies de animais. Os cães são um dos principais reservatórios urbanos da Leishmania Infantum e desempenham um papel central no ciclo de transmissão para os seres humanos utilizando flebotomíneos. A apoptose de linfócitos está envolvida na regulação da resposta imune da LV, podendo contribuir para uma resposta imune ineficaz porque o mecanismo efetor não reduz a multiplicação do patógeno. Um importante regulador da apoptose é a proteína FAS (Cluster de diferenciação 95 CD95) e proteína ligante FAS-FASL (Cluster de diferenciação 178-CD178), sistema envolvido na baixa regulação de reações imunes mediadas por células T citotóxicas. A proteína FAS é um membro de receptor da superfamília fator de necrose tumoral (TNF) que pode ser expresso na forma transmembrana ou solúvel. Os níveis das proteínas solúvel FAS (sFAS), solúvel FASL (sFASL), e caspase 3 ativa, essa última relacionada a cascata apoptótica, foram determinados por ensaio de ELISA de captura nos extratos do baço de 19 cães sintomáticos apresentando LV moderada e em 6 cães saudáveis. A carga parasitária esplênica foi determinada por PCR em tempo real com amplificação do segmento intergênico espaçador transcrito interno 1 (ITS1) do gene de rRNA do parasita. Foi realizada a correlação entre os níveis de sFAS e sFAS-L com a carga parasitária explênica. Os cães com leishmaniose apresentaram menores níveis de sFAS (p<0,05) e elevados níveis de sFASL e caspase 3 ativa (p<0,05) no baço que os cães saudáveis. Além disso, foi observada correlação negativa entre a carga parasitária e os níveis de sFASL nos cães infectados. Conclui-se que o aumento do sFASL pode estar relacionado com o mecanismo envolvido na eliminação do parasita
Visceral Leishmaniosis (VL) is caused by intracellular parasites of the genus Leishmania that affect humans and several animal species. Dogs are one of the main urban reservoirs of Leishmania infantum and play a central role in the transmission cycle to humans via sandflies. CD3+ cells apoptosis is involved in the immune response in VL. Dysregulation of apoptosis has been implicated in various disease states. An important regulator of apoptosis is the FAS-FAS-associated death domain protein (cluster of differentiation 95-CD95) and FASL-FAS ligand protein (cluster of differentiation 178-CD178) system involved in the down-regulation of immune reactions and in T cell-mediated cytotoxicity. FAS is a member of the tumor necrosis factor (TNF) receptor super family, which can be expressed in transmembrane or soluble forms. The soluble levels of FAS (sFAS), FASL (sFASL) and active Caspase-3, this last related to apoptotic cascade, were investigated in the spleen of 19 symptomatic dogs presenting moderate VL and 6 healthy dogs, determined by ELISA assay. The splenic parasite load was determined by real-time PCR monitoring of amplification of the intergenicinternal transcribed spacer (ITS1) gene of parasite rRNA. sFAS levels were lower (p <0.05) sFASL and active Caspase-3 levels were higher (p<0.05) in dogs with VL compared with controls. Negative correlation was observed between parasite burden and sFASL levels. The increase in sFASL could be related to the mechanism involved in the elimination of the parasite.
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Borges, Juliana Perosso. "Alteração da expressão de sFAS e sFASL na leishmaniose voisceral canina / Juliana Perosso Borges. -." Araçatuba, 2014. http://hdl.handle.net/11449/124435.
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Orientador: Valéria Marçal Félix de LimaBanca:Gisele Fabrino Machado
Banca: Hélio José Montassier
Resumo: A leishmaniose visceral (LV) é causada por parasitas intracelulares do gênero Leishmania que afeta humanos e várias espécies de animais. Os cães são um dos principais reservatórios urbanos da Leishmania Infantum e desempenham um papel central no ciclo de transmissão para os seres humanos utilizando flebotomíneos. A apoptose de linfócitos está envolvida na regulação da resposta imune da LV, podendo contribuir para uma resposta imune ineficaz porque o mecanismo efetor não reduz a multiplicação do patógeno. Um importante regulador da apoptose é a proteína FAS (Cluster de diferenciação 95 CD95) e proteína ligante FAS-FASL (Cluster de diferenciação 178-CD178), sistema envolvido na baixa regulação de reações imunes mediadas por células T citotóxicas. A proteína FAS é um membro de receptor da superfamília fator de necrose tumoral (TNF) que pode ser expresso na forma transmembrana ou solúvel. Os níveis das proteínas solúvel FAS (sFAS), solúvel FASL (sFASL), e caspase 3 ativa, essa última relacionada a cascata apoptótica, foram determinados por ensaio de ELISA de captura nos extratos do baço de 19 cães sintomáticos apresentando LV moderada e em 6 cães saudáveis. A carga parasitária esplênica foi determinada por PCR em tempo real com amplificação do segmento intergênico espaçador transcrito interno 1 (ITS1) do gene de rRNA do parasita. Foi realizada a correlação entre os níveis de sFAS e sFAS-L com a carga parasitária explênica. Os cães com leishmaniose apresentaram menores níveis de sFAS (p<0,05) e elevados níveis de sFASL e caspase 3 ativa (p<0,05) no baço que os cães saudáveis. Além disso, foi observada correlação negativa entre a carga parasitária e os níveis de sFASL nos cães infectados. Conclui-se que o aumento do sFASL pode estar relacionado com o mecanismo envolvido na eliminação do parasita
Abstract: Visceral Leishmaniosis (VL) is caused by intracellular parasites of the genus Leishmania that affect humans and several animal species. Dogs are one of the main urban reservoirs of Leishmania infantum and play a central role in the transmission cycle to humans via sandflies. CD3+ cells apoptosis is involved in the immune response in VL. Dysregulation of apoptosis has been implicated in various disease states. An important regulator of apoptosis is the FAS-FAS-associated death domain protein (cluster of differentiation 95-CD95) and FASL-FAS ligand protein (cluster of differentiation 178-CD178) system involved in the down-regulation of immune reactions and in T cell-mediated cytotoxicity. FAS is a member of the tumor necrosis factor (TNF) receptor super family, which can be expressed in transmembrane or soluble forms. The soluble levels of FAS (sFAS), FASL (sFASL) and active Caspase-3, this last related to apoptotic cascade, were investigated in the spleen of 19 symptomatic dogs presenting moderate VL and 6 healthy dogs, determined by ELISA assay. The splenic parasite load was determined by real-time PCR monitoring of amplification of the intergenicinternal transcribed spacer (ITS1) gene of parasite rRNA. sFAS levels were lower (p <0.05) sFASL and active Caspase-3 levels were higher (p<0.05) in dogs with VL compared with controls. Negative correlation was observed between parasite burden and sFASL levels. The increase in sFASL could be related to the mechanism involved in the elimination of the parasite.
Mestre
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Pilar, Ana Victoria. "Biochemical and molecular characterization of the glycosomal PTS2 import receptor peroxin 7 in «Leishmania donovani»." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32255.
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The Leishmania peroxin 7 (LmPEX7 or LdPEX7) is the receptor that translocates PTS2 signal-containing proteins into the glycosome. This microbody is unique to and crucial for the survival of trypanosomatids which include Leishmania and Trypanosoma, the causative agents of leishmaniasis and African sleeping sickness, respectively. Proteins are imported into the glycosome via two pathways, PTS1 and PTS2, which involves the formation of a PTS-receptor complex in the cytosol, docking of the complex on a translocation apparatus on the glycosomal membrane, and subsequent release of the cargo protein into the lumen. However, the precise steps in glycosome protein trafficking are not well-defined and to understand the function of these organelles and prove their potential as chemotherapeutic targets, the mechanism of glycosome biogenesis needs to be fully elucidated. Not much is known about the mechanism of PTS2 import pathway in glycosomes as studies on PEX7 have been hampered by the difficulty in expressing a soluble recombinant form of this receptor. To dissect the PTS2 import pathway and to determine the role of PEX7 in Leishmania, this protein was cloned and characterized. LmPEX7 is a ~41 kDa protein containing six conserved WD40 motifs that displays limited sequence similarity to PEX7 homologues involved in the biogenesis of evolutionarily-related peroxisomes found in other eukaryotes. LmPEX7 interacts with PTS2 proteins, the PTS1 receptor LdPEX5, and the membrane-associated docking protein LdPEX14. These interactions, characterized through various biochemical techniques, were mediated by specific binding domains, formation of stable protein-protein complexes, and conformLa péroxine Leishmania 7 (LmPEX7 ou LdPEX7) est un récepteur qui transloque les protéines qui contiennent le signal PTS2 dans le glycosome. Ce glycosome est unique et critique aux trypanosomes, tels que Leishmania et Trypanosoma, les agents causant la leishmaniose et la maladie Africaine du sommeil. Les protéines sont importées vers le glycosome par deux voies, PTS1 et PTS2, qui nécessitent la formation d'un complexe PTS dans le cytosol, l'amarrage du complexe sur un appareil de translocation sur la membrane du glycosome, et permet la liberation de la charge protéique dans le lumen. Par contre, les étapes précises dans l'acheminement de protéines glycosomales ne sont pas bien définies et pour comprendre les fonctions de ces organelles et prouver qu'elles être des cibles chimiothérapiques, les mécanismes impliqués dans la biogenèse doivent être très bien élucidés. Pour disséquer le mécanisme d'importation et pour déterminer le rôle de PEX7 chez Leishmania, cette protéine a été clonée à partir de l'ADN génomique de L. major et a été caractérisée. LmPEX7 est une protéine d'environ 41 kDa qui démontre une homologie limitée aux PEX7 impliqués dans la biogenèse des peroxysomes chez autres eucaryotes. LmPEX7 interagit avec les protéines PTS2, le récepteur PTS1 LdPEX5, ainsi que la protéine LdPEX14 qui est associée à la membrane du glycosome. Ces intéractions, décrites en utilisant des techniques biochimiques variées, sont arbitrés par des domaines d'interactions situés sur LdPEX5 et LdPEX14, la formation de complexes protéiques stables, et associée à divers changements conformationnels. Des études de localisation subcellula
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Scherlis, Gerardo. "Presidents and parties in Latin America: the exceptionality of peronism in the Latin American context." Politai, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/91944.
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Political parties have ceased fulfilling substantial representative functions. Their legitimacy lies now on their role as governmental agencies. This led to an increasing interpenetration between parties and the states, and to the empowerment of those leaders that occupy executive offices. In the Latin American context these features are particularly intense in the case of ruling parties in countries where traditional parties collapsed or suffered significant brand dilution. In these cases the president controls the ruling party, while the «really existent» party organization is built up on the basis of networks recruited by the elected leader to run the government. The central argument of this article is that Peronism is the sole political force which has managed to adapt successfully to the conditions of electoral competition in contemporary Argentina. The president´s autonomy in terms of public policies´ in relation to a political machine sustained on the basis of the control of sub-national states makes it possible to disentangle the legitimacy of the party from that of its current national leadership. This scheme provides Peronism with a successful self-preservation mechanism, which is exceptional in the Latin American context.Los partidos políticos han dejado de cumplir funciones representativas significativas para legitimarse a partir de su rol como agencias de gobierno. Esto ha implicado la creciente inter- penetración entre partidos y estados, así como la concentración de recursos en los líderes que ocupan cargos ejecutivos. En el contexto latinoamericano, estas características alcanzan mayor intensidad en los partidos de gobierno de países en los que se ha producido el colapso o la dilu- ción del valor de la etiqueta de los partidos tradicionales. En estos casos, el presidente controla al partido de gobierno, mientras la estructura partidaria realmente existente se constituye sobre la base de las redes reclutadas por el líder electo para el ejercicio del gobierno.El argumento central del artículo consiste en que el peronismo es la única fuerza política que ha logrado adaptarse exitosamente a las condiciones de la competencia electoral en la Argentina contemporánea. La autonomía del presidente en términos de orientación de políticas públicas frente a una máquina partidaria sostenida sobre la base del control de los estados subnacionales hace posible escindir la legitimidad del partido respecto a la de su coyuntural liderazgo. Esto provee al peronismo de un exitoso mecanismo de preservación, excepcional en el contexto latinoamericano.
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Sato, Yasuhiko. "Characterization of the interaction between peroxin Pex3p and Pex19p involved in peroxisomal membrane protein translocation." 京都大学 (Kyoto University), 2008. http://hdl.handle.net/2433/137150.
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Perrault, Anne-Julie. "The Peronist labor movement and the Alfonsin government : an uneasy relationship for Argentina's democracy (1983-1989)." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56937.
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The aim of the thesis is to analyze the Peronist labor movement's role in the Argentine democratic consolidation process. Some scholars, as Valenzuela, have underlined the important role of labor movements in the consolidation of the new democratic regimes emerging from the end of authoritarian rule. This role consists in the moderation of labor's mobilizational activities and militant demands. However, these scholars have not sufficiently emphasized the weakness and the reduced weight of some labor movements after military repression and economic structural transformations. The thesis examines the Argentine case and demonstrates how the several general strikes organized by the CGT during Alfonsin's government did not hinder Argentine democratic consolidation in the short term. The thesis underlines the weakening of the Peronist labor movement and explains its minor role in the consolidation process.
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McLean, James. "Purification and characterization of the Leishmania PTS2 receptor, Peroxin 7, an essential receptor for glycosme biogenesis." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110401.
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The trypanosomatid parasite Leishmania infects 12 million people in tropical countries. This neglected tropical disease causes debilitating and often fatal consequences in the absence of chemotherapeutic intervention. Consequently, there is a need to identify new drug targets to combat the increasing incidence of resistance to current treatments. An attractive drug target in these parasites is the glycosome, a unique microbody organelle that compartmentalizes several essential enzymatic pathways behind an impermeable membrane. The Leishmania major Peroxin 7 (LPEX7) is a receptor protein that recognizes glycosomal matrix proteins containing an N-terminal peroxisomal targeting signal 2 (PTS2) and facilitates the trafficking of these proteins across the glycosomal membrane. Genetic studies in the related trypanosomatid parasite, Trypanosoma brucei, have demonstrated that PEX7 is essential for parasite viability. LPEX7 is predicted to have a hydrophobic outer surface which has made production of this recombinant protein in the E. coli heterologous system challenging. LPEX7 was successfully purified in the presence of non-ionic detergents, however, this limited the usefulness of this protein in regards to downstream in vitro studies with glycosomal membranes. To investigate the biophysical role of LPEX7 in the trafficking and import of proteins into the glycosome, we have developed a strategy to reliably express and purify recombinant Leishmania PEX7 in the absence of detergents. Subsequent biochemical studies confirmed that the recombinant LPEX7 was functionally active and, like the native protein or detergent purified protein, binds LdPEX5 and PTS2 cargo proteins with nanomolar affinities. Initial investigations of the quaternary structure demonstrated that LPEX7 is in equilibrium between a dimer and tetramer in solution. Preliminary protein-protein interaction domain mapping studies have demonstrated that the C-terminal half LPEX7 was sufficient to bind both LdPEX14 and LdPEX5.Le parasite trypanosomatide Leishmania affecte plus de 12 millions d'individus dans les pays tropicaux. Cette maladie tropicale négligée a de graves conséquences, parfois fatales, en absence d'interventions thérapeutiques. Il y a, par conséquent, urgence d'identifier de nouvelles cibles thérapeutiques pour combattre ce fléau et restreindre l'incidence de résistance envers les médicaments présentement employés. Une cible thérapeutique de choix s'est révélée récemment dans cette famille de parasite. Il s'agit du glycosome, un organelle qui compartimente plusieurs voies métaboliques derrière une membrane imperméable. La Péroxine 7 de Leishmania major (LPEX7) est un récepteur cytosolique qui reconnaît certaines protéines destinées pour le glycosome contenant un signal peptidique de type 2 (PTS-2) à leur terminal N et qui facilite le transport vers la membrane du glycosome. Récemment, des études génétiques sur le parasite trypanosomatide Trypanosoma brucei ont démontré que PEX7 est essentiel pour la survie du parasite. Des prédictions bio-informatiques révèlent que LPEX7 contient une surface extérieure hydrophobe, ce qui explique le défi que représente la production de cette protéine de façon recombinante dans le système E. coli. LPEX7 fut purifiée avec succès en présence de détergents ioniques, ce qui a toutefois limité les possibilités d'études d'interactions avec des membranes. Dans le but d'étudier le rôle biophysique de LPEX7 dans le transport et l'importation de protéines vers le glycosome, nous avons développé une stratégie pour exprimer et purifier LPEX7 de façon recombinante en l'absence de détergents. Ensuite, nos études biochimiques ont confirmé que LPEX7 recombinante est active et, tout comme LPEX7 précédemment purifiée avec l'aide de détergents, est capable de lier les protéines contenant un signal PTS-2 et LdPEX5 à des concentrations nano-molaires. Une investigation de la structure quaternaire de LPEX7 a révélé que le récepteur s'assemble en dimères et tétramères en solution. Finalement, des études préliminaires d'interaction protéine-protéine ont illustré que LPEX7 contient un site d'attachement pour LdPEX5 et LdPEX14 sur la demie portion terminale C.
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Mayerhofer, Peter Uli. "Functional characterization of the human peroxins PEX3 and PEX19, proteins essential for early peroxisomal membrane biogenesis." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969361378.
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Gerstle, Kirstin [Verfasser], and Ulrich [Akademischer Betreuer] Hahn. "Charakterisierung der sRNAs RybA und HB_428 unter Peroxid-Stress in Escherichia coli / Kirstin Gerstle. Betreuer: Ulrich Hahn." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2011. http://d-nb.info/1020466294/34.
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Jess, Anne-Cathrin [Verfasser]. "Vergleichende Untersuchung der Peroxid-Clearance von C6-Astrogliomazellen und primär kultivierten Astrozyten der Ratte / Anne-Cathrin Jess." Kiel : Universitätsbibliothek Kiel, 2011. http://d-nb.info/1020245255/34.
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Vránová, Lenka. "Vývoj Argentiny v průběhu perónistických vlád." Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-75613.
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This thesis focuses on political and economic development during the peronist governments. This does not mean just the periods of Perón's rule, but also the governments in the nineties and early in the new millennium. The thesis is divided into three chapters, which are further divided into various subsections. The first part deals with peronist movement and economic and political characteristics of the three J. D. Peron's governments. The second chapter focuses on the Carlos Menem's rule, especially on his neo-liberal reforms. Final section analyzes the causes of economic crisis in Argentina and then describes the course as well. Attention is also paid to postcrises development in both economic and political area.
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Pacifico, Denise. "Sintese de perolas do hidrogel de poli-2-HEMA e estudo de sua utilização em liberação controlada de drogas." [s.n.], 1995. http://repositorio.unicamp.br/jspui/handle/REPOSIP/266411.
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Orientador: Lucia Helena Innocentini MeiDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Quimica
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Resumo: Este trabalho teve como meta principal a síntese de pérolas de tamanho uniforme do hidrogel de poli-2-hidroxietilmetacrilato (poli-2-REMA) e o estudo de sua utilização em sistemas de liberação controlada de drogas. A síntese foi feita utilizando-se alginato de cálcio como molde de polimerização e obteve-se, como resultado final, pérolas uniformes (2-3 mm de diâmetro) do hidrogel poli-2-REMA. As pérolas do hidrogel foram utilizadas em estudos de absorção e liberação de substâncias (ácido fólico e o corante alaranjado de metila), através de um método de otimização estatístico denominado Planejamento Fatorial, onde estudou-se a influência de três importantes variáveis (pH, tempo e Temperatura) e suas interações na resposta, que no caso deste trabalho foi a Absorbância de uma solução. Os melhores resultados foram obtidos com o corante alaranjado de metila cujas equações para os processos de absorção e liberação, são, respectivamente: A = 0.5193 + 0.1050 pH - 0.0343 t e A = 0.0289 - 0.0119 pH + 0.0143 t - 0.0034 pH x t. Em ambos os casos, absorção e liberação, observou-se que baixo pH e longo tempo favoreceram os processos; alto pH degradou o polímero e Temperatura não teve influência significativa na resposta. Através da Microscopia Eletrônica de Varredura obteve-se fotomicrografias que permitiram observar a porosidade das pérolas do hidrogel
Abstract: The aim of this work was the synthesis of poly-2- hydroxyethylmethacrylate(poly-2-HEMA)hydrogel and its utilization as drug delivery system. The synthesis was carried out using calcium alginate as moulder for the polymerization reaction and the result obtained was the hydrogel beads of poly-2-HEMA with uniform size of 2-3mm in diameter. These beads were furthermore utilized to the study of absorption and release of folic acid and methyl orange applying a Statistical Technique following the influence of three important variables as pH, time and temperature as well as their interactions with the data measured, that is, absorbance of the solution. The best results were obtained with the methyl orange whose equations for the absorption and delivery process are respectively: A = 0.5193 + 0.1050 pH - 0.0343 t and A = 0.0289 - 0.0119 pH + 0.0143 t - 0.0034 pH x t. In both cases it was observed that low pH and long time afIect the process; high values of pH degrade the polymer and polymer and temperature did not influence significantelythe results. Through MEV it was obtained the micrography that allowed us to observe the porosity of the hydrogel beads
Mestrado
Ciencia e Tecnologia de Materiais
Mestre em Engenharia Química
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Silva, Paulo Renato da. "Alpagartas si, libros no? : produção cultural e legitimidade politica durante o governo de Peron (1946-1955)." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/280450.
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Orientador: Jose Alves de Freitas NetoTese (doutorado) - Universidade Estadual de Campinas, Instituto de Filosofia e Ciencias Humanas
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Resumo: Esta pesquisa levantou a produção cultural argentina durante o governo de Juan Domingo Perón (1946-1955). O estudo indicou a existência de uma expressiva produção cultural alinhada com o peronismo, resultado de uma política cultural do governo. Entretanto, essa política cultural não prevaleceu na produção cultural do período. ascensão de Perón não impediu o reconhecimento de escritores antiperonistas como Borges, Bioy Casares, Victoria Ocampo e Julio Cortázar, dentre outros, ligados à tradição liberal argentina. Além disso, entre os próprios peronistas, as propostas culturais do governo provocaram divergências quanto à centralidade do nacionalismo, à formação que deveria ser dada aos setores populares e ao legado da tradição liberal.
Abstract: This research investigated Argentina's cultural output during the government of Juan Domingo Perón (1946-1955). The study identified the existence of substantial cultural output aligned with Peronism as a result of the government's cultural policies. However, these policies did not completely direct the country's cultural production during this period. For instance, Perón's rise to power did not prevent recognition of antiperonist writers such as Borges, Bioy Casares, Victoria Ocampo, and Julio Cortázar, among others, who represented Argentina's liberal tradition. In addition, the government's cultural proposals led to meaningful disagreements among the Peronists themselves over the centrality of nationalism, the training proffered to the population at large, and the legacy of the liberal tradition.
Doutorado
Historia Cultural
Doutor em História
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Bückert, Elvira [Verfasser]. "Einfluss der humanen Aldo-Keto-Reduktase AKR1B10 auf die Überlebensfähigkeit Peroxid-behandelter CaCo-2- und V-79-Zellen / Elvira Bückert." Kiel : Universitätsbibliothek Kiel, 2012. http://d-nb.info/1020284358/34.
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Souza, Renata A. Melki de. "A imagem de Eva : o governo peronista." Pontifícia Universidade Católica de São Paulo, 2016. https://tede2.pucsp.br/handle/handle/19229.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Conselho Nacional de Desenvolvimento Científico e Tecnológico
This dissertation intends to analyze the image of Eva Perón, between 1939 and e1955 as sources, I'll use the press, Brazilian newspapers, Argentines and the biography 'the Reason of my life,' published in 1951 in Buenos Aires, the other end of this research is to question what was the role of Eva in the Peronist government, which the focus and the look of the press when it comes to the first lady of Argentina and the directions that lead to have this position In addition to show how Perón Argentina is inserted, as the Colonel came to power and the importance of workers for the regime. The work is relevant, therefore, Avoids was one of the most important women of the 20th century, for his performance and his political charisma with the population, also because of the permanence of his memory and Peronism, the papers and biography will be analyzed fully observing its structure, movement, positioning and relations, not only by the news itself. A support frame is the ample bibliography used, that will help me understand how Peronism was organized politically, the political life and work of Maria Eva Duarte and its importance to the polity, workers, trade unions as the basis for the government, its origin and the relationship built even before Perón to the presidency, especially the devotion of Evita, as social action and Justicialism became his reason for living and her enthusiasm for the cause of the humble
Esta dissertação tem como objetivo a análise da imagem de Eva Perón, entre de 1939 a 1955 e utiliza como fontes de pesquisa a imprensa, brasileira e argentina, e a biografia “A Razão de minha Vida”, publicada em 1951, em Buenos Aires. Outro fim desta pesquisa é questionar qual foi o papel de Eva no regime peronista, qual o foco e o olhar quando se fala da primeira-dama argentina e quais os direcionamentos que levaram a imprensa a ter esta posição, além de mostrar como a Argentina de Perón está inserida no contexto mundial. Como o coronel chegou ao poder e qual a importância dos trabalhadores. O trabalho é relevante, pois Evita foi uma das mulheres mais importantes do século XX, seja por sua atuação política e seu carisma com a população, seja pela permanência de sua memória e do próprio peronismo. Os jornais e a biografia serão analisados inteiramente observando sua estrutura, circulação, relações e posicionamento, não somente pela notícia em si. Um referencial de apoio é a farta bibliografia utilizada, que me forneceu subsídios para compreender como o peronismo se organizou politicamente, a vida e atuação política de Maria Eva Duarte e sua importância para o regime, possibilitou ainda o entendimento do papel dos operários, sindicatos e grêmios como base para o governo, aclarou a origem de Eva e a relação construída com Perón mesmo antes dele chegar à presidência e, principalmente, a devoção de Evita à ajuda social e ao Justicialismo, que se tornaram sua razão de viver e alimentaram seu fervor pela causa dos humildes
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Jirsová, Tereza. "Proměny peronistického populismu v Argentině." Master's thesis, Vysoká škola ekonomická v Praze, 2012. http://www.nusl.cz/ntk/nusl-197271.
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Peronism has been one of the most widely used terms in the context of Argentinean politics, history and culture over the last 60 years. In spite of the fact that there is no official definition of the term, many different political strategies in Argentina are referred to as Peronist. Why is it so complicated to define the concept of Peronism? What does it really mean when Argentinean presidents claim to be Peronists? This thesis is based on the hypothesis that Peronism is primarily brand of political populist projects. The first chapter classifies the concept of populism, the second chapter deals with the particular populism in Latin America and the third chapter analyzes the individual mandates of Peronist presidents. The analysis strongly supports the working hypothesis.
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Souza, Camilla Fontes de. "La acción cambiante: da luta armada aos direitos humanos nos cartazes argentinos (1973-1984)." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/8/8138/tde-06012014-122402/.
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Esta pesquisa objetiva analisar as representações dos imaginários políticos argentinos durante os anos de 1973 e 1984, por meio dos cartazes de propaganda produzidos no período. Estes anos selecionam um período conturbado da história argentina, o governo peronista (1973) e o governo militar do Processo de Reorganização Nacional (1976-1983), em que as posições políticas se acirram em nome de projetos para a nação e, após a violenta e sistemática repressão da ditadura provocou mudanças sensíveis na forma de atuação política. A escolha do cartaz como fonte para a análise desta pesquisa histórica de dá por este se configurar como um veículo de difusão e circulação de mensagens de caráter efêmero, mas que possui potencial para atingir um grande número de pessoas. Essa fonte compõe um elemento rico em representações dos imaginários políticos, sobre as visões e concepções de futuro e das críticas e anseios que seus grupos elaboradores desejavam divulgar para um grande público. As fontes visuais possibilitam um sem número de inferências, mobilizam elementos simbólicos, culturais, políticos, históricos, nacionais e universais, sempre partilhando com seu observador as referências representacionais para, enfim, cumprir seu papel de comunicar uma mensagem idealizada por seus realizadores. Nesta pesquisa, a análise dos cartazes procura revisitar um período conturbado da história argentina e, por meios destes, reconstruir parte do imaginário político do período.This research aims to analyze the representations of imaginary Argentine politicians during the years 1973 and 1984, by means of propaganda posters produced in the period. These years select a turbulent period in Argentine history, the Peronist government (1973) and the military government of the National Reorganization Process (1976-1983), in which the political positions is stoked on behalf of projects for the nation and, after violent and systematic repression of the dictatorship generated sensible changes in the form of political action. The choice of the poster as a source for analysis of historical research gives for this is set up as a vehicle for the dissemination and circulation of messages ephemeral, but which has the potential to reach large numbers of people. This source comprises an element rich representations of the political imaginary, the visions and conceptions of the future and criticisms and concerns that their groups drafters wished to disseminate to a wide audience. Visual sources allow any number of inferences, mobilize symbolic elements, cultural, political, historical, national and universal, always sharing with its observer representational references to finally fulfill its role of communicating a message designed by their makers. In this research, the analysis of the posters attempts to revisit a period of Argentine history and troubled by these means, to rebuild part of the political imaginary of the period.
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Carreras, Sandra. "Die Rolle der Opposition im Demokratisierungsprozess Argentiniens : der Peronismus, 1983-1989 /." Frankfurt am Main : Vervuert, 1999. http://www.loc.gov/catdir/toc/fy0608/00347527.html.
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Perovic-Rott, Nevena [Verfasser], Ernst [Akademischer Betreuer] Rank, Ralf-Peter [Gutachter] Mundani, Ernst [Gutachter] Rank, and Miriam [Gutachter] Mehl. "Coupling of Models and Scales in Computational Fluid Dynamics / Nevena Perovic-Rott ; Gutachter: Ralf-Peter Mundani, Ernst Rank, Miriam Mehl ; Betreuer: Ernst Rank." München : Universitätsbibliothek der TU München, 2021. http://d-nb.info/1241246831/34.
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Orloff, Carolina. "Representation of the political in selected writings of Julio Cortázar." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/5530.
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This thesis analyses the evolution of the representation of distinct political elements through Julio Cortázar’s writings, mainly with reference to the novels and the so-called collage books. I also allude to some short stories and refer to many of Cortázar’s nonliterary texts. Through this chosen corpus, I trace a thematic thread showing that politics was present in Cortázar’s fiction from his very first writings, and not – as he himself tended to claim – only following his conversion to socialism after a lifechanging trip to revolutionary Cuba. My analysis aims to show that in opposition to what many critics have argued, this crucial point in his life did not divide the writer into an irreconcilable before and after – the apolitical versus the political –, but rather, it simply shifted the emphasis of the representation of the political, which already existed in Cortázar’s writings. In order to trace this process, I carry out my analysis in chronological order, not of the publication of the works, but of the actual time when they were written. Therefore, in the first chapter, I look at some of the books written between 1948 and 1951, namely, Divertimento (1949), El examen (1950) and Diario de Andrés Fava (1951), focusing mainly on El examen; I then extend the analysis to Los premios (1960), written when Cortázar was already living in Paris. Chapter two focuses on Rayuela (1963) and the action/inaction dilemma as reflected in the novel’s protagonist. The third chapter considers a period of conflict for Cortázar, as he tries to come up with a way in which to write literature for the political revolution of Latin America, without compromising his belief in artistic freedom. To elucidate this phase, I analyse 62/modelo para armar (1968) on the one hand, and the collage books, La vuelta al día en ochenta mundos (1967) and Último Round (1969), on the other. My fourth and final chapter examines Libro de Manuel (1973), Cortázar’s explicit attempt to converge literature, politics and history, and assesses the results of this effort to merge art and politics, allegedly without making aesthetic concessions. Although there have been works analysing the political dimension of specific texts (particularly of his short stories), no study to date has analysed the evolution of the political element throughout Cortázar’s writings, from the first unpublished novels to his later more experimental works. The originality of my thesis lies in the tracing of this progression through an extensive analysis of these works. My examination is also original insofar as it refers to unpublished material – a selection of Cortázar’s manuscripts from Princeton University Library – to the most recent posthumous publications – such as Papeles inesperados (2009) – and to a series of personal interviews with Argentinian writers associated with Cortázar. This research therefore hopes to bring unique insight that will further the overall understanding of this major and influential writer of the twentieth century.
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RENEVIER, BUISINE CATHERINE. "Un cas rare de syndrome sapho (synovite, acne, pustulose palmo-plantaire, hyperostose, osteite) revele par une periostite des perones : a propos d'une observation personnelle." Lyon 1, 1990. http://www.theses.fr/1990LYO1M084.
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Loew, Noya. "Meerrettich Peroxidase : Modifikationen und Anwendungen in Biosensoren." Phd thesis, Universität Potsdam, 2008. http://opus.kobv.de/ubp/volltexte/2008/1843/.
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Biosensoren werden oft für die Messung einzelner Substanzen in komplexen Medien verwendet, wie z.B. bei der Blutzuckerbestimmung. Sie bestehen aus einem physikochemischen Sensor, dem Transduktionselement, und einer darauf immobilisierten biologischen Komponente, dem Erkennungselement. In dieser Arbeit wurde als Transduktionselement eine Elektrode und als Biokomponente das Enzym „Meerrettich Peroxidase“ (engl. horseradish peroxidase, HRP) verwendet. Solche HRP-Elektroden werden für die Messung von Wasserstoffperoxid (H2O2) eingesetzt.
H2O2 wird im Körper von weißen Blutkörperchen produziert, um Bakterien abzutöten, wird teilweise ausgeatmet und kann in kondensierter Atemluft nachgewiesen werden. Da viele weiße Blutkörperchen bei einer Chemotherapie abgetötet und dadurch die Patienten anfälliger für Infektionen werden, muss ihre Anzahl regelmäßig überwacht werden. Dazu wird zurzeit Blut abgenommen. Im ersten Teil dieser Arbeit wurde untersucht, ob eine Überwachung der Anzahl an weißen Blutkörperchen ohne Blutabnahme durch eine H2O2-Messung erfolgen kann. Ein direkter Zusammenhang zwischen der ausgeatmeten H2O2-Menge und der Zahl der weißen Blutkörperchen konnte dabei nicht festgestellt werden.
Für empfindliche H2O2-Messungen mit einer HRP-Elektrode ist ein schneller Austausch von Elektronen zwischen der Elektrode und dem Enzym notwendig. Eine Vorraussetzung dafür ist eine kurze Distanz zwischen dem aktiven Zentrum des Enzyms und der Elektrodenoberfläche. Um einen kurzen Abstand zu erreichen wurden im zweiten Teil dieser Arbeit verschiedene poröse graphitähnliche Materialien aus pyrolysierten Kobalt-Porphyrinen für die Elektrodenherstellung verwendet. Dabei stellte sich heraus, dass eines der untersuchten Materialien, welches Poren von etwa der Größe eines Enzyms hat, Elektronen etwa 200mal schneller mit dem Enzym austauscht als festes Graphit.
Die HRP selbst enthält in seinem aktiven Zentrum ein Eisen-Protoporphyrin, also ein aus vier Ringen bestehendes flaches Molekül mit einem Eisenatom im Zentrum. Reagiert die HRP mit H2O2, so entzieht es dem Peroxid zwei Elektronen. Eines dieser Elektronen wird am Eisen, das andere im Ringsystem zwischengespeichert, bevor sie an ein anderes Molekül oder an die Elektrode weitergegeben werden. Im letzten Teil dieser Arbeit wurde das Eisen durch Osmium ausgetauscht. Das so veränderte Enzym entzieht Peroxiden nur noch ein Elektron. Dadurch reagiert es zwar langsamer mit Wasserstoffperoxid, dafür aber schneller mit tert-Butylhydroperoxid, einem organischen Vertreter der Peroxid-Familie.Biosensors are often used for the measurement of specific substances in complex media, e.g. glucose in blood. They consist of a physicochemical sensor, the transducer, onto which a biological component, the recognition element, is immobilised. In this work, an electrode was used as transducer and the enzyme “horseradish peroxidase” (HRP) as biological component. Such HRP electrodes are used for the measurement of hydrogen peroxide (H2O2). H2O2 is produced in the body by white blood cells to destroy bacteria, is partially exhaled and can be measured in breath condensate. Since a lot of white blood cells are destroyed during chemotherapy and patients get more prone to infections, their amount must be checked regularly. Currently blood samples are taken for this purpose. In the first part of this work it was investigated, if the amount of white blood cells can be checked without taking blood by measuring H2O2. A correlation between the amount of exhaled H2O2 and the number of white blood cells could not be found. For a sensitive H2O2 measurement with an HRP electrode a quick exchange of electrons between electrode and enzyme is needed. One condition for this is a short distance between the active centre of the enzyme and the electrode surface. In order to achieve a short distance, several porous graphite-like materials made of pyrolysed cobalt porphyrins where used in the second part of this work for the electrode production. It turned out that one of the tested materials, which had pores about the same size as the enzyme, did exchange electrons with the enzyme about 200 times faster than solid graphite. HRP itself contains an iron protoporphyrin, i.e. a planar molecule consisting of four rings with an iron atom in the middle, its active centre. When HRP reacts with H2O2, it takes two electrons from the peroxide. One of these electrons is stored at the iron, the other in the ring system, until they are passed on to another molecule or the electrode. In the last part of this work, the iron was exchanged with osmium. The modified enzyme takes only one electron from peroxides. Thus it reacts slower with hydrogen peroxide, but faster with tert-butylhydroperoxide, an organic member of the peroxide family.
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Demarchi, Julio Cesar [UNESP]. "Geotecnologias aplicadas à estimativa de perdas de solo por erosão hídrica na sub-bacia do Ribeirão das Perobas, Município de Santa Cruz do Rio Pardo-SP." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/90559.
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demarchi_jc_me_botfca.pdf: 1445779 bytes, checksum: 2bbfc0965a5bf3563befc20f86bd5d66 (MD5)Universidade Estadual Paulista (UNESP)
A erosão do solo constitui o principal fator de degradação das terras agrícolas. Ela é influenciada por fatores climáticos, pela suscetibilidade natural dos solos, características do relevo e intervenção antrópica através do uso, manejo do solo e das práticas conservacionistas, que podem acelerá-la ou reduzi-la. O objetivo deste trabalho é realizar uma estimativa de perda de solo por erosão hídrica na Sub-Bacia do Ribeirão das Perobas, localizada no município de Santa Cruz do Rio Pardo – SP, através da Equação Universal de Perda de Solo Revisada (RUSLE), utilizando ferramentas de Geoprocessamento e Sensoriamento Remoto. Foi elaborado o mapa detalhado de solos da sub-bacia, a partir do qual se determinou a erodibilidade, a tolerância de perda de solo e se efetuou a classificação das terras no sistema de capacidade de uso. Os mapas de erosividade da chuva, fator topográfico, uso e manejo do solo e práticas conservacionistas foram elaborados em ambiente de Sistema de Informação Geográfica (SIG) a partir de dados do programa netErosividade SP, do modelo digital de elevação do terreno e de imagens de satélite, respectivamente. Foram determinados o Potencial Natural de Erosão, a perda de solo (cenário atual), a Capacidade de uso-manejo permissível, o Risco de Erosão Simulado e a Expectativa de Erosão da sub-bacia.Dois cenários de perda de solos foram simulados: 1) adequação do uso, manejo e práticas conservacionistas à capacidade de uso, e 2) áreas agricultáveis ocupadas por cana-de-açúcar sem manejo e plantio em nível. A estimativa de perda de solo através da RUSLE evidenciou que a erosão resulta da interação de fatores dos meios físico e antrópico, mas sofreu maior influência do fator C (uso e manejo do solo). O mapa de capacidade de uso-manejo permissível, associado à capacidade de uso da terra...
Soil erosion is the main factor of agricultural land degradation. It is influenced by climatic factors, natural susceptibility of soils, topography characteristics and by human intervention, through land cover, management and support practices, which can increase it or reduce it. This work aims to perform an estimation of soil loss by water erosion in Ribeirão das Perobas Sub-basin, located in Santa Cruz do Rio Pardo, São Paulo state, through Revised Universal Soil Loss Equation (RUSLE), using GIS and Remote Sensing tools. It was elaborated the detailed soil map of the sub-basin, from which were determined the erodibility, soil loss tolerance and it was performed the land classification into the land use capacity system. Rainfall erosivity, topographic factor, cover-management and support practices maps were elaborated in GIS (Geographical Information System), using the netErosividade SP program, the digital elevation model and the satellite images, respectively. The Natural Potential of Erosion, the soil loss (current scenario), the Permissible Land Cover-Management Capacity, the Simulated Erosion Risk and the Sub-basin Erosion Expectation were determined. Two soil loss scenarios were simulated: 1) adequacy of the cover-management and the support practices to the land use capacity, and 2) farming areas occupied by sugarcane crops without management and contour tillage. The soil loss estimation through RUSLE showed that erosion results from the interaction of natural and anthropogenic factors, but it suffered more influence of the C factor (soil cover and management). The Permissible Land Cover-Management map, associated with... (Complete abstract click electronic access below)
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Demarchi, Julio Cesar 1986. "Geotecnologias aplicadas à estimativa de perdas de solo por erosão hídrica na sub-bacia do Ribeirão das Perobas, Município de Santa Cruz do Rio Pardo-SP /." Botucatu :, 2012. http://hdl.handle.net/11449/90559.
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Orientador: Célia Regina Lopes ZimbackBanca: Maria Cristina Perusi
Banca: Sergio Lazaro de Lima
Resumo: A erosão do solo constitui o principal fator de degradação das terras agrícolas. Ela é influenciada por fatores climáticos, pela suscetibilidade natural dos solos, características do relevo e intervenção antrópica através do uso, manejo do solo e das práticas conservacionistas, que podem acelerá-la ou reduzi-la. O objetivo deste trabalho é realizar uma estimativa de perda de solo por erosão hídrica na Sub-Bacia do Ribeirão das Perobas, localizada no município de Santa Cruz do Rio Pardo - SP, através da Equação Universal de Perda de Solo Revisada (RUSLE), utilizando ferramentas de Geoprocessamento e Sensoriamento Remoto. Foi elaborado o mapa detalhado de solos da sub-bacia, a partir do qual se determinou a erodibilidade, a tolerância de perda de solo e se efetuou a classificação das terras no sistema de capacidade de uso. Os mapas de erosividade da chuva, fator topográfico, uso e manejo do solo e práticas conservacionistas foram elaborados em ambiente de Sistema de Informação Geográfica (SIG) a partir de dados do programa netErosividade SP, do modelo digital de elevação do terreno e de imagens de satélite, respectivamente. Foram determinados o Potencial Natural de Erosão, a perda de solo (cenário atual), a Capacidade de uso-manejo permissível, o Risco de Erosão Simulado e a Expectativa de Erosão da sub-bacia.Dois cenários de perda de solos foram simulados: 1) adequação do uso, manejo e práticas conservacionistas à capacidade de uso, e 2) áreas agricultáveis ocupadas por cana-de-açúcar sem manejo e plantio em nível. A estimativa de perda de solo através da RUSLE evidenciou que a erosão resulta da interação de fatores dos meios físico e antrópico, mas sofreu maior influência do fator C (uso e manejo do solo). O mapa de capacidade de uso-manejo permissível, associado à capacidade de uso da terra... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Soil erosion is the main factor of agricultural land degradation. It is influenced by climatic factors, natural susceptibility of soils, topography characteristics and by human intervention, through land cover, management and support practices, which can increase it or reduce it. This work aims to perform an estimation of soil loss by water erosion in Ribeirão das Perobas Sub-basin, located in Santa Cruz do Rio Pardo, São Paulo state, through Revised Universal Soil Loss Equation (RUSLE), using GIS and Remote Sensing tools. It was elaborated the detailed soil map of the sub-basin, from which were determined the erodibility, soil loss tolerance and it was performed the land classification into the land use capacity system. Rainfall erosivity, topographic factor, cover-management and support practices maps were elaborated in GIS (Geographical Information System), using the netErosividade SP program, the digital elevation model and the satellite images, respectively. The Natural Potential of Erosion, the soil loss (current scenario), the Permissible Land Cover-Management Capacity, the Simulated Erosion Risk and the Sub-basin Erosion Expectation were determined. Two soil loss scenarios were simulated: 1) adequacy of the cover-management and the support practices to the land use capacity, and 2) farming areas occupied by sugarcane crops without management and contour tillage. The soil loss estimation through RUSLE showed that erosion results from the interaction of natural and anthropogenic factors, but it suffered more influence of the C factor (soil cover and management). The Permissible Land Cover-Management map, associated with... (Complete abstract click electronic access below)
Mestre
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Němcová, Lucie. "Studium vlivu elektrolytů na stabilitu a efektivitu diafragmového výboje." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2008. http://www.nusl.cz/ntk/nusl-216391.
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This thesis is focused on so-called diaphragm discharge, which is one kind of electric discharges in liquid, which belongs among so-called AOP´s techniques, still more used for water cleaning in the present. One of effectiveness and stability indicators of diaphragm discharge is generation of hydrogen peroxide. In theoretical part, detail principle description of electric discharge in liquid is situated. Further, properties of electrolyte are introduced and general spectrophotometric method of obtained sample determination is described. In experimental part, a full procedure of experiment is introduced. Next part containing results and discussions introduces particular results of individual measurements and their reasons. Final chapter is the end, which forms total summary and evaluation of all results. By the application of all chosen electrolytes in solution at diaphragm discharge formation of hydrogen peroxide has appeared. Inorganic and organic electrolytes were used. As inorganic electrolytes following salts were selected – solutions of halogenides, next sodium nitrate as a representative of nitrates, potassium dihydrogenphosphate as a representative of phosphates, etc. Representative of organic electrolytes was citric acid. The value of initial conductivity of electrolytes had the main influence on hydrogen peroxide formation. Electrolytes potassium dihydrogenphosphate and sodium sulphate the great influence on effectiveness and stability of the diaphragm discharge. Their rate constants reached maximum value by the application of solution with initial conductivity of approximately 400 mikrosiemens, particularly 0.0492 mmol/l.min and 0.048 mmol/l.min. On the contrary, low values of rate constant were achieved in electrolyte ammonium chloride at around the same initial conductivity – 0.0269 mmol/l.min. During experiments stainless steel and platinum electrodes were used. It was found that kind of electrode material hadn’t influence on generation of hydrogen peroxide. Hydrogen peroxide was formed only in the cathode space.
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Hudec, Tomáš. "Hospodářský a socio-politický vývoj Argentiny po roce 1976 a perspektivy budoucího vývoje." Master's thesis, Vysoká škola ekonomická v Praze, 2013. http://www.nusl.cz/ntk/nusl-192564.
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This master's thesis describes economic and socio-political development of Argentina from 1976 up until the current situation. The last chapter introduces the perspectives of the future development as well. During this period, Argentina experienced a lot of changes when the country switched from policy of ISI to neoliberalism which was the main policy of Argentina from 1976 until the default in 2001, with the exception of Alfonsín's presidency. The thesis deals with the main causes of this default. The next part of the work examines what led the country to the economic recovery after 2002 and explains the changes that have occured during the period of Kirchnerism.
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Perovic, Milena [Verfasser], Markus [Akademischer Betreuer] Antonietti, Yan [Akademischer Betreuer] Lu, Martin [Akademischer Betreuer] Oschatz, Markus [Gutachter] Antonietti, Martin [Gutachter] Oschatz, and Joanna [Gutachter] Gościańska. "Functionalization of nanoporous carbon materials for chiral separation and heterogeneous oxidation catalysis / Milena Perovic ; Gutachter: Markus Antonietti, Martin Oschatz, Joanna Gościańska ; Markus Antonietti, Yan Lu, Martin Oschatz." Potsdam : Universität Potsdam, 2020. http://d-nb.info/1223981134/34.
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Lago, Mayra Coan. "Trabalhadores do Brasil, Mis Queridos Descamisados: a (re) invenção dos trabalhadores no varguismo e no peronismo." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/84/84131/tde-22062015-120752/.
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Este trabalho tem como objetivo estudar os imaginários sociais sobre os trabalhadores no varguismo e no peronismo. Posteriormente, pretendemos comparar os imaginários sociais sobre os trabalhadores no Estado Novo (1937-1945) com os do Primeiro Peronismo (1946- 1955), visando estabelecer aproximações e distanciamentos entre os mesmos. Para lograr o objetivo, analisaremos os discursos políticos de Getúlio Vargas e Juan Domingo Perón em duas festas cívicas específicas de seus países, isto é: 10 de novembro e o Primeiro de Maio, entre os anos 1937-1945, no Brasil; e o 17 de outubro e o Primeiro de Maio, entre os anos 1946-1955. A partir da análise dos discursos políticos, sobretudo relacionados aos imaginários sociais sobre os trabalhadores, propomos a ideia de uma (re) invenção dos trabalhadores, composta pela combinação de aspectos imateriais ou simbólicos com os aspectos materiais.This work aims to study the social imaginary on workers in Varguism and Peronism. Subsequently, we intend to compare the social imaginary of workers in the Estado Novo (1937-1945) with the Primeiro Peronismo (1946-1955), to establish similarities and differences between them. To achieve the goal, we will analyze the political speeches of Getúlio Vargas and Juan Domingo Perón in two specific civic events in their countries: 10 of November and the first of May, between the years 1937-1945, in Brazil; and the 17 of October and the first of May, between the years 1946-1955. From the analysis of the political discourse, particularly in relation to social imaginary about the workers, we propose the idea of a reinvention of workers, composed by the combination of immaterial or symbolic aspects with the material aspects.
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Francatto, Patrícia. "Reatividade das nanopartículas de dióxido de titânio com a superfície modificada por grupos peróxo." Universidade Federal de São Carlos, 2016. https://repositorio.ufscar.br/handle/ufscar/7720.
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
The welfare of the human population depends of the technological and scientific development. However, this model of economic growth has generated a huge ecological impact. For this reason, it is necessary new and more efficient processes and methods of synthesis to sage energy. This study employed a new approach of the "The Oxidant PeroxoMethod" (OPM) to obtain highly reactive nanoparticles of titanium dioxide (TiO2) with the surface modified with peroxide groups (TiO2 -OPM). We synthesized these TiO2-OPM using titanium metal and titanium isopropoxide as titanium source and to evaluate the reactivity of these precursors, two different composition of bismuth titanates (the selenita Bi12TiO20 and the perovskite Bi4Ti3O12 phases) were synthesized by means of the conventional solid-state reaction. These materials were characterized using differential scanning calorimetry (DSC), thermogravimetric analysis (TG), X-ray diffraction (XRD), Raman spectroscopy and scanning eléctron (SEM) and transmission eléctron (TEM) microscopies. We observed that both TiO2-OPM precursors are identical reagarding their reactivity and structure, with the advantage that the material synthesized from the alcooxide is easier, cheaper and faster that the material obtained from titanium metal. Moreover, we could observe that the peroxide groups on the surface of the nanoparticles were resposable by the reactivity of these nanoparticles, as observed by the lower temperatures used to obtain single phase bismuth titanates with different composition.
Cada vez mais o desenvolvimento industrial e tecnológico estão atrelados ao bem estar da população, na maioria das vezes este intenso progresso na industria e na tecnologia gera um elevado volume de resíduos e um alto consumo de energia. Em razão disso, há uma necessidade de novas rotas de síntese que sejam eficientes produtivamente para a obtenção de novos materiais mas que ao mesmo tempo sejam mais econômicas e ambientalmente sustentáveis. Desta maneira, o presente estudo visou compreender e aumentar a utilização de uma nova rota de síntese,o método dos complexos oxidantes de peróxido (a rota OPM). Esta rota por via úmida, também conhecida como "The Oxidant Peroxo Method" (OPM), permite a síntese de nanopartículas de dióxido de titânio (TiO2) com a superfície modificada com o grupo peróxo (TiO2-OPM), aumentando a reatividade das nanopartículas. Esta rota foi utilizada com o objetivo de estudar a reatividade dessas nanopartículas modificadas. Foram realizadas sínteses de TiO2 -OPM a partir de titânio metálico (met-TiO2-OPM) e de isopropóxido de titânio (iso- TiO2-OPM). A síntese a partir do isopropóxido se mostrou mais rápida e um pouco mais eficiente do que a do titânio metálico. Para comprovar essa alta reatividade foram sintetizados titanatos de bismuto em diferentes fases, a selenita (Bi12TiO20) e a perovskita (Bi4Ti3 O12) a partir do TiO 2-OPM por reação no estado sólido. Os materiais obtidos foram caracterizados por técnicas análises térmicas como calorimetria diferencial de varredura (DSC) e a análise térmica (TG) e estruturalmente por difratometria de Raios X (DRX) e espectroscopia de espalhamento Raman. A microscopia eletrônica de varredura (MEV) e microscopia eletrônica de transmissão (TEM) também foram utilizadas para verificar as morfologias destes materiais. Com a obtenção dos pós precursores pela rota OPM foi possível observar que os grupos peroxos formados na superfície do TiO2 foram responsáveis pela elevada reatividade observada, isto foi comprovado através da obtenção das diferentes fases do titanato de bismuto utilizando uma simples reação no estado sólido. O material precursor, TiO2- OPM, não apresentou uma morfologia definida, porém apresentou uma pequena cristalização devido aos picos largos apresentados no DRX, e também foi possível observar uma mistura de fases. Os titanatos de bismuto apresentaram as fases correspondentes, as partículas dos titanatos obtidos com o precursor iso - TiO2-OPM se apresentaram menores do que as do precursor met - TiO2-OPM.
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Mhamdi, Amna. "Cytosolic enzymes involverd in NADP+ and glutathione reduction : roles in H2 O2 metabolism and signaling in arabidopsis." Paris 11, 2010. http://www.theses.fr/2010PA112167.
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L’augmentation de la disponibilité des espèces actives de l’oxygène, comme le H2 O2 est une caractéristique commune aux réponses aux stress biotiques et abiotiques. L’accumulation du H2 O2 est contrôlée par les catalases ou par les peroxydases. Ces derniers systèmes dépendent des réducteurs cellulaires comme l’ascorbate et le glutathion, dont les teneurs sont soutenues par le NADPH. Le flux augmenté via ces voies peut provoquer des perturbations (comme celles qui peuvent affecter le statut thiol-disulfure) qui prennent le relais pour la transduction des signaux oxydatifs. Bien que plusieurs enzymes puissent réguler le système NADPH-glutathion dans le cytosol, l’importance physiologique de chacune de ses enzymes reste à élucider. Cette étude est basée sur la combinaison d’approches génétiques, biochimiques, transcriptomiques et métaboliques dans le but d’analyser les rôles de la glutathion réductase cytosolique (GRI) et des déshydrogénases NADP-dépendantes dans le métabolisme, les réponses induites par le H2 O2 et la résistance aux pathogènes. L’analyse comparative des mutants T-ADN des trois catalases d'Arabidopsis a révélé que seulement cat2 montre des perturbations redox et un stress oxydatif conditionnel au niveau foliaire. Cette lignée a été donc utilisée comme un fond génétique pour examiner l'importance du système NADPH-glutathion cytosoliquedans la réponse au H₂ O₂ produit au niveau intracellulaire par une voie physiologiquement pertinente (la photorespiration). L'analyse comparative des mutants gr1, cat2 e(t cat2 gr1 a révélée que GR1 joue un rôle déterminant dans les réponses des feilles au H₂ O₂intracellulaire et qu'elle asure une expression génique appropriée via les voies de signalisation par l'acide salicylique (AS) et par l'acide jasmonique. Une strtégie similaire a été utilisée pour explorer les fonctions de l'isocitrate déshydrogène cytosolique à NADP (ICDH) et des deux glucose-6-phosphate déshydrogénases cytosoliques (G6PPD5 et G6PD6). Cette analyse a montré que ces trois enzymes contribuent au maintient du statut glutathion dans le fond cat2. L'étude a aussi révélée que la mutation icdh et les mutations g6pd produisent des effets distincts où antagonistes par rapport à la mort cellulaire déclenchée par H2 O2 aux réponses aux pathogènes SA dépendantes et à la résistance aux bactéries. Ainsi, l'étude montre que la GR ne peut être remplacée par la deuxième GR ou par le système thiorédoxine dans les conditions de sur-disponibilité de H2 O2 et met en évidence les fonctions spécifiques des systèmes cytosoliques producteurs de NADPH dans la détermination des résultantes du stress oxdatifIncreased availability of ractive oxygen species asuch as H2 O2 is a feature of biotic and abiotic stresses. H2 O2 accumulation is controlld either by catalases or by peroxidases. The second depend on cellular reductants such as ascorbate and glutathione, both of which are supported by NADPH pools. Increased flux through these pools may cause perturbations (eg. In thiol-disulfide statud) that act in the relay of H2 O2-dependent redox signals. Although several enzyme systems are known that could regulate the NADPH-glutathione system in the cytosoln the significance of each remians largely unknown. This study look a combined genetic, biochemicaln and transcript and metablotie profiling approach to analyzing the roles of cytosolic glutathione reductase (GR) and NADP-dependent dehydrogenases in metabolism, H2 O2-triggered responses, and biotic stress. Comparative analysis of T-DNA mutants for the three Arabidopsis catalases revealed that only cat2 showed conditional redox pertubation and stress in rosettes. This line was therefore used as a gnentic background to investigate the importance of the cytosolic NADPH-glutathione system in response to H₂ O₂ produced intracellularly through a physiologically relevant pathway (photorespiration). Comparative analysis of gr1, cat2 and cat2 gr1 mutant lines revealed that GR1 plays a crucial role in leaf reponses to intracellular H2 O2 and is required to ensure appropriate gene expression throug both salicylic acid (SA) and jasmonic acid signaling pathways. Using a similar strategy, the functions of cytosolic NADP-isocitrate dehydrogenase (ICDH) an the two cytosolic glucose-6-phosphate dehydrogenases (G6PD5 and G6PD6) were explored. This analysis provided evidence that all three dehydrogenases contribuate to maintaining glutathione status under conditions of increased H₂ O₂ availability but revealed that the icdh and g6pd mutations produce distinct or opposing effects on H2 O2-triggered cell death, SA-dependent pathogenesis reponses and bacterial resistance. Thus, the study shows that GRI cannot be replaced by the second GR or by the thioredoxin system under conditions of increased H2 O2 and provides evidence for the specificity of cytosolic NADPH-producing systems in determining the outcome of oxidative stress
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Peroni, Marco [Verfasser], Johannes A. [Akademischer Betreuer] [Gutachter] Lercher, and Dirk [Gutachter] Weuster-Botz. "Transition Metal Phosphides Catalysts for the Hydroprocessing of Triglycerides to Green Fuel. / Marco Peroni ; Gutachter: Johannes A. Lercher, Dirk Weuster-Botz ; Betreuer: Johannes A. Lercher." München : Universitätsbibliothek der TU München, 2017. http://d-nb.info/1132248728/34.
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Haines, Andrés Ernesto Ferrari. "O peronismo : um fenômeno argentino, uma interpretação da política econômica argentina : 1946-1955." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/12588.
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É comum conceber o peronismo como a experiência argentina de um fenômeno amplo de processos de industrialização, em geral em países com economias baseadas no setor primário, habitualmente denominado populismo. Sem entrar diretamente nesses debates, afirma-se neste trabalho que para compreender o peronismo é necessário explicitar questões muito concretas que compõem a história argentina, que podem ou não se repetir em outras sociedades. Especificamente, se afirma que não é possível entender o peronismo a partir de um impulso industrializador – sem por isto negar-lhe aspectos nesse sentido – dado que este processo já estava em curso, e devido ao fato de não se observar que esse setor tenha experimentado um desenvolvimento fora da tendência longo prazo da manufatura. Em contrapartida, o peronismo apresenta outras características peculiares da sociedade argentina, como o conflito que já tinha surgido em pleno auge do modelo agroexportador pela disputa social de participação política e por cargos dirigentes contra a elite tradicional. Na realidade, as variantes possiveis da Pampa Úmida na história é o eixo central que viabiliza deduzir as chaves da Argentina, inclusive do peronismo.Peronism is usually conceived as the argentine experience of a much wider phenomenon of events linked to the industrialization of countries with economies based on the primary sector, usually termed populism. Without directly getting into those debates, this work states that in order to understand peronism, specification of some very concrete issues is required - which are entrenched into argentine history that might not apply to other cases. In particular, it sustains that peronism cannot be understood merely from a drive for industrialization – without eliminating needs in that direction – as it was already in course and due to the fact that manufacture did not experience any development out of its long term tendency. On the other hand, peronism brought forth other issues which had already presented themselves in argentine society, even though it might have exteriorized them in a much higher intensity, such as social conflict caused by the dispute for participation in political and social management against the traditional elite that had already emerged during the peak of the primary-export model. In fact, the changing possibilities of the Pampas over the years are the main axis that enables the understanding of Argentina’s main characteristics, including peronism.