Academic literature on the topic 'Peroxisome proliferator-activated receptor gamma coactivator 1-alpha'

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Journal articles on the topic "Peroxisome proliferator-activated receptor gamma coactivator 1-alpha"

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Reyes-Gordillo, Karina, Ruchi Shah, Ravi Varatharajalu, Mamatha Garige, Leslie C. Leckey та M. Raj Lakshman. "Low-ω3 Fatty Acid and Soy Protein Attenuate Alcohol-Induced Fatty Liver and Injury by Regulating the Opposing Lipid Oxidation and Lipogenic Signaling Pathways". Oxidative Medicine and Cellular Longevity 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/1840513.

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Chronic ethanol-induced downregulation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) and upregulation of peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC1β) affect hepatic lipid oxidation and lipogenesis, respectively, leading to fatty liver injury. Low-ω3 fatty acid (Low-ω3FA) that primarily regulates PGC1αand soy protein (SP) that seems to have its major regulatory effect on PGC1βwere evaluated for their protective effects against ethanol-induced hepatosteatosis in rats fed with Lieber-deCarli control or ethanol liquid diets with high
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Park, Seon-Joo, Miey Park, Anshul Sharma, Kihyun Kim, and Hae-Jeung Lee. "Black Ginseng and Ginsenoside Rb1 Promote Browning by Inducing UCP1 Expression in 3T3-L1 and Primary White Adipocytes." Nutrients 11, no. 11 (2019): 2747. http://dx.doi.org/10.3390/nu11112747.

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In this study, we investigated the effects of black ginseng (BG) and ginsenoside Rb1, which induced browning effects in 3T3-L1 and primary white adipocytes (PWATs) isolated from C57BL/6 mice. BG and Rb1 suppressed the expressions of CCAAT/enhancer-binding protein alpha (C/EBPα) and sterol regulatory element-binding transcription factor-1c (SREBP-1c), whereas the expression level of peroxisome proliferator-activated receptor gamma (PPARγ) was increased. Furthermore, BG and Rb1 enhanced the protein expressions of the brown-adipocyte-specific markers PR domain containing 16 (PRDM16), peroxisome p
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Donate-Correa, Javier, Beatriz Martín-Carro, Jorge B. Cannata-Andía, Carmen Mora-Fernández, and Juan F. Navarro-González. "Klotho, Oxidative Stress, and Mitochondrial Damage in Kidney Disease." Antioxidants 12, no. 2 (2023): 239. http://dx.doi.org/10.3390/antiox12020239.

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Reducing oxidative stress stands at the center of a prevention and control strategy for mitigating cellular senescence and aging. Kidney disease is characterized by a premature aging syndrome, and to find a modulator targeting against oxidative stress, mitochondrial dysfunction, and cellular senescence in kidney cells could be of great significance to prevent and control the progression of this disease. This review focuses on the pathogenic mechanisms related to the appearance of oxidative stress damage and mitochondrial dysfunction in kidney disease. In this scenario, the anti-aging Klotho pr
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Wu, Haijiang, Xinna Deng, Yonghong Shi, Ye Su, Jinying Wei та Huijun Duan. "PGC-1α, glucose metabolism and type 2 diabetes mellitus". Journal of Endocrinology 229, № 3 (2016): R99—R115. http://dx.doi.org/10.1530/joe-16-0021.

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Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by glucose metabolic disturbance. A number of transcription factors and coactivators are involved in this process. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) is an important transcription coactivator regulating cellular energy metabolism. Accumulating evidence has indicated that PGC-1α is involved in the regulation of T2DM. Therefore, a better understanding of the roles of PGC-1α may shed light on more efficient therapeutic strategies. Here, we review the most recent progress on PGC-1α and dis
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Lee, Yong-Jik, Yoo-Na Jang, Yoon-Mi Han, Hyun-Min Kim, Jong-Min Jeong та Hong Seog Seo. "Fimasartan Ameliorates Nonalcoholic Fatty Liver Disease through PPARδ Regulation in Hyperlipidemic and Hypertensive Conditions". PPAR Research 2017 (2017): 1–14. http://dx.doi.org/10.1155/2017/8048720.

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To investigate the effects of fimasartan on nonalcoholic fatty liver disease in hyperlipidemic and hypertensive conditions, the levels of biomarkers related to fatty acid metabolism were determined in HepG2 and differentiated 3T3-L1 cells treated by high fatty acid and liver and visceral fat tissue samples of spontaneously hypertensive rats (SHRs) given high-fat diet. In HepG2 cells and liver tissues, fimasartan was shown to increase the protein levels of peroxisome proliferator-activated receptor delta (PPARδ), phosphorylated 5′ adenosine monophosphate-activated protein kinase (p-AMPK), phosp
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Walsh, Jeremy J., Brittany A. Edgett, Michael E. Tschakovsky, and Brendon J. Gurd. "Fasting and exercise differentially regulate BDNF mRNA expression in human skeletal muscle." Applied Physiology, Nutrition, and Metabolism 40, no. 1 (2015): 96–98. http://dx.doi.org/10.1139/apnm-2014-0290.

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Brain-derived neurotrophic factor (BDNF) gene expression was measured in human skeletal muscle following 3 intensities of exercise and a 48-h fast. No change in BDNF mRNA was observed following exercise, while fasting upregulated BDNF by ∼3.5-fold. These changes were dissociated from changes in peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) following exercise (+2- to 15-fold) and fasting (∼–25%). These results challenge our understanding of the response of BDNF to energetic stress and highlight the importance of future work in this area.
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Sudeep, Heggar Venkataramana, Illuri Ramanaiah, Raj Amritha, Puttaswamy Naveen, Kuluvar Gouthamchandra, and Kodimule Shyamprasad. "A Standardized Aframomum melegueta Seed Extract Regulates Browning of White Adipose Tissue in High-Fat Diet Model Mice." Natural Product Communications 16, no. 9 (2021): 1934578X2110337. http://dx.doi.org/10.1177/1934578x211033744.

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Thermogenesis-mediated energy expenditure is a promising strategy to combat obesity. Aframomum melegueta commonly known as grains of paradise (GP) is a popular spice with medicinal attributes in promoting health. We have demonstrated the thermogenic effects of a standardized A melegueta seed extract (AMSE) containing not <10% 6-paradol in high fat diet-fed (HFD) mice. The 6-week oral ingestion of 20 and 40 mg/kg AMSE significantly limited the weight gain, improved the brown adipose tissue (BAT) activity in HFD mice. Interestingly, AMSE markedly induced the beige adipocytes in epididymal whi
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Eddy, Sean F., та Kenneth B. Storey. "Differential expression of Akt, PPARγ, and PGC-1 during hibernation in bats". Biochemistry and Cell Biology 81, № 4 (2003): 269–74. http://dx.doi.org/10.1139/o03-056.

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The effects of hibernation on the expression of Akt (protein kinase B), the peroxisome proliferator-activated receptor gamma isoform (PPARγ), and the PPARγ coactivator PGC-1 were assessed in seven tissues of the little brown bat, Myotis lucifugus. Western blotting revealed that the levels of active phosphorylated Akt were strongly reduced in brain, kidney, liver, and white adipose during torpor as compared with aroused animals and that total Akt protein was also reduced in white adipose during torpor. By contrast, both total and phospho-Akt were elevated in brown adipose tissue, the thermogeni
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Kakuma, Tetsuya, Zhuo-Wei Wang, Wentong Pan, Roger H. Unger, and Yan-Ting Zhou. "Role of Leptin in Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Expression1." Endocrinology 141, no. 12 (2000): 4576–82. http://dx.doi.org/10.1210/endo.141.12.7804.

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Yu, Jin, Hong Zhu, Saeid Taheri, Stephen Perry, and Mark Kindy. "The Effect of Diet on Improved Endurance in Male C57BL/6 Mice." Nutrients 10, no. 8 (2018): 1101. http://dx.doi.org/10.3390/nu10081101.

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The consumption of fruits and vegetables appears to help with maintaining an adequate level of exercise and improves endurance. However, the mechanisms that are involved in this process are not well understood. In the current study, the impact of diets enriched in fruits and vegetables (GrandFusion®) on exercise endurance was examined in a mouse model. GrandFusion (GF) diets increased mitochondrial DNA and enzyme activity, while they also stimulated mitochondrial mRNA synthesis in vivo. GF diets increased both the mRNA expression of factors involved in mitochondrial biogenesis, peroxisome prol
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Dissertations / Theses on the topic "Peroxisome proliferator-activated receptor gamma coactivator 1-alpha"

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Attia, Ramy Naguib. "Regulation of pyruvate dehydrogenase kinase 4 by thyroid hormone role of peroxisome proliferator activated receptor gamma coactivator-1 Alpha and CCAAT enhancer binding protein /." View the abstract Download the full-text PDF version, 2009. http://etd.utmem.edu/ABSTRACTS/2009-007-Attia-index.htm.

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Thesis (Ph.D.)--University of Tennessee Health Science Center, 2009.<br>Title from title page screen (viewed on July 22, 2009). Research advisor: Edwards A. Park. Document formatted into pages (xi, 94 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 69-89).
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Abdel, Khalek Waed. "Sirt3, une déacetylase mitochondriale NAD+dépendante, est impliquée dans la regulation de la différenciation des myoblastes." Thesis, Montpellier 2, 2013. http://www.theses.fr/2013MON20022/document.

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Sirt3, une des sept sirtuines chez les mammifères, est une déacétylase mitochondriale NAD+-dépendante qui joue un rôle dans le contrôle des facteurs clés de plusieurs voies métaboliques. Sirt3 déacétyle et active un grand nombre d'enzymes mitochondriales impliquées dans l'activité de la chaîne respiratoire, la production d'ATP, le cycle de Krebs, ainsi que le cycle de l'urée. Parallèlement à son rôle dans le métabolisme énergétique, l'activité mitochondriale intervient également dans l'induction de l'apoptose ainsi que dans la régulation de la prolifération et la différenciation cellulaires. E
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Gonçalves, Natália Gomes. "Síndrome metabólica e declínio cognitivo: papel do exercício físico." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5144/tde-11092018-153547/.

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Evidências disponíveis na literatura sugerem uma conexão entre ingestão de frutose, síndrome metabólica e declínio cognitivo. Na sociedade ocidental, o aumento de casos de síndrome metabólica ocorreu em paralelo ao aumento do consumo de excesso de frutose na dieta. Além disso, animais que consomem excesso de frutose em sua dieta apresentam alterações típicas de resistência à insulina em seus cérebros, além de desenvolverem declínio cognitivo. Sabe-se que exercício físico é capaz de prevenir atrofia do hipocampo e atenuar declínio cognitivo. O objetivo desse estudo foi avaliar se exercício aeró
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Snider, Trevor. "Evaluating the role of peroxisome proliferator-activated receptor gama coactivator-1 alpha in mitochondrial biogenesis in goldfish." Thesis, 2013. http://hdl.handle.net/1974/8254.

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The production of ATP is of the utmost importance to cell survival. To maintain energy homeostasis, cells regulate mitochondrial content through the control of degradative and synthetic processes. Mitochondrial biogenesis is primarily controlled through a small number of transcriptional regulators, primarily nuclear respiratory factor-1 (NRF-1), NRF-2, and peroxisome proliferator-activated receptors (PPARs). DNA-binding proteins regulate genes encoding the machinery of oxidative phosphorylation. In addition to these DNA-binding proteins, the coactivator PPAR gamma coactivator-1 alpha (PGC-1α
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Book chapters on the topic "Peroxisome proliferator-activated receptor gamma coactivator 1-alpha"

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Xie, Xuemei, and Xiaoping Luo. "Peroxisome Proliferator-Activated Receptor-Gamma Coactivator-1Alpha and DNA Methylation as Epigenetic Control." In Handbook of Nutrition, Diet, and Epigenetics. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-31143-2_75-1.

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"Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha." In Encyclopedia of Signaling Molecules. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_102855.

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"Peroxisome Proliferative-Activated Receptor, Gamma, Coactivator 1, Alpha." In Encyclopedia of Signaling Molecules. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_102854.

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Yazawa, Takashi, Akihiro Umezawa, and Kaoru Miyamoto. "Peroxisome Proliferator-Activated Receptor-gamma Coactivator-1 alpha Regulates Progesterone Production in Ovarian Granulosa Cells with Steroidogenic Factor-1 and Liver Receptor Homolog-1." In The Endocrine Society's 92nd Annual Meeting, June 19–22, 2010 - San Diego. Endocrine Society, 2010. http://dx.doi.org/10.1210/endo-meetings.2010.part2.p8.p2-377.

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Conference papers on the topic "Peroxisome proliferator-activated receptor gamma coactivator 1-alpha"

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Jiang, WG, X. Li, and RE Mansel. "P2-05-02: PGC1, Peroxisome Proliferator Activated Receptor-gamma (PPAR-gamma) Coactivator-1, Is Necessary in PPAR-gamma Modulated Angiogenesis." In Abstracts: Thirty-Fourth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 6‐10, 2011; San Antonio, TX. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/0008-5472.sabcs11-p2-05-02.

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