Relevant bibliographies by topics / Personalized gene therapy

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Personalized gene therapy'

Author: Grafiati
Published: 14 March 2023
Last updated: 31 July 2025

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Journal articles on the topic "Personalized gene therapy"

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Grinstein, Jonathan D. "Personalized Gene Therapy for All." Inside Precision Medicine 12, no. 2 (2025): 18–20. https://doi.org/10.1089/ipm.12.02.06.

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Schaly, Sabrina, Merry Ghebretatios, and Satya Prakash. "Baculoviruses in Gene Therapy and Personalized Medicine." Biologics: Targets and Therapy Volume 15 (April 2021): 115–32. http://dx.doi.org/10.2147/btt.s292692.

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Vemula, Greeshma¹ Dr. C. Bhuvaneswar Rao² Dr. Venu Gopal³. "The Impact of Artificial Intelligence in Gene Therapy." International Journal of Scientific Research and Technology 1, no. 11 (2024): 185–201. https://doi.org/10.5281/zenodo.14233536.

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Artificial intelligence (AI) is revolutionizing the field of gene therapy by enabling more precise, efficient, and personalized treatments. AI tools, particularly machine learning (ML) and deep learning (DL) algorithms, are being leveraged to analyze large genomic datasets, identify potential gene targets, and predict the outcomes of genetic modifications. These AI-driven approaches can optimize gene editing techniques like CRISPR-Cas9 by predicting off-target effects and improving editing accuracy. Moreover, AI enhances the design of gene delivery systems, aiding in the development of safer a
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Harris, Tim. "Gene and drug matrix for personalized cancer therapy." Nature Reviews Drug Discovery 9, no. 8 (2010): 660. http://dx.doi.org/10.1038/nrd3181-c1.

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Kohno, Takashi, Koji Tsuta, Katsuya Tsuchihara, Takashi Nakaoku, Kiyotaka Yoh, and Koichi Goto. "RETfusion gene: Translation to personalized lung cancer therapy." Cancer Science 104, no. 11 (2013): 1396–400. http://dx.doi.org/10.1111/cas.12275.

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Karra, Geetha, Abhiram Ch, Hanisha Tungala, Anusha Suddala, Manoj Reddy Ch, and Rama Rao Tadikonda. "Artificial Intelligence-Driven Advances in Haemophilia Gene Therapy." International Journal of Current Science Research and Review 08, no. 02 (2025): 680–87. https://doi.org/10.5281/zenodo.14824075.

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Abstract : Hemophilia is the most frequent severe genetic haemorrhagic condition. Hemophilia A and B are caused by a lack or dysfunction of the factor VIII and factor IX proteins, respectively, and are distinguished by prolonged and heavy bleeding after minor trauma or even spontaneously. Treatments for hemophilia have been extremely expensive and required the infusion of plasma clotting factors throughout one’s life. The last few years have brought major breakthroughs in gene therapy that now hold real promise for possible curative options. Artificial intelligence has the potential to t
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Kamsochukwu Ego, Obi, Ojong Naomi Agbor, and Ola-Oluwa Samuel Ayomide. "Assessing the Actuarial Implications of Gene Therapy and Personalized Medicine in Nigeria: A Case Study of Cancer Treatment." International Journal of Research and Scientific Innovation XI, no. XV (2024): 139–46. http://dx.doi.org/10.51244/ijrsi.2024.11150010p.

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This study investigates the actuarial implications of gene therapy and personalized medicine in cancer treatment in Anambra State, Nigeria. The research design was a descriptive survey, with 60 patients diagnosed with cancer from 20 general hospitals in Anambra State selected using purposive sampling. The questionnaire, titled “Questionnaire on Actuarial Implications of Gene Therapy and Personalized Medicine for Cancer Treatment” (QAIGPMCT), was structured and validated. The Cronbach Alpha Method was used to determine internal consistency and descriptive statistics of mean were used to answer
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Iacobas, Sanda, and Dumitru Andrei Iacobas. "Personalized 3-Gene Panel for Prostate Cancer Target Therapy." Current Issues in Molecular Biology 44, no. 1 (2022): 360–82. http://dx.doi.org/10.3390/cimb44010027.

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Many years and billions spent for research did not yet produce an effective answer to prostate cancer (PCa). Not only each human, but even each cancer nodule in the same tumor, has unique transcriptome topology. The differences go beyond the expression level to the expression control and networking of individual genes. The unrepeatable heterogeneous transcriptomic organization among men makes the quest for universal biomarkers and “fit-for-all” treatments unrealistic. We present a bioinformatics procedure to identify each patient’s unique triplet of PCa Gene Master Regulators (GMRs) and predic
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Barthélémy, Florian, and Nicolas Wein. "Personalized gene and cell therapy for Duchenne Muscular Dystrophy." Neuromuscular Disorders 28, no. 10 (2018): 803–24. http://dx.doi.org/10.1016/j.nmd.2018.06.009.

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Sneha, Kumari* Dr. Rakhi Kapadiya Dr. Jitendra Banweer. "Biopharmaceuticals And Gene Therapy." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2289–98. https://doi.org/10.5281/zenodo.15409831.

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Biopharmaceuticals and gene therapy are new and powerful tools in today’s medicine. They offer precise and innovative ways to treat complex diseases. Biopharmaceuticals are made with biotechnology and include proteins for therapy, antibodies that target specific cells, and vaccines. These treatments work well with fewer side effects. Gene therapy changes or replaces faulty genes to help fight or stop diseases like cancer, genetic illnesses, and viral infections. Recent progress in methods to deliver genes, such as using viruses or other carriers, has made these treatments safer and more
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Dissertations / Theses on the topic "Personalized gene therapy"

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Patsali, Petros. "Advanced personalized gene therapy of B-thalassaemia." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/advanced-personalized-gene-therapy-of-bthalassaemia(4e7d967d-eec8-4663-ae40-bd36b1793a71).html.

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Thalassaemias are amongst the commonest single‐gene disorders worldwide, but offer only limited curative treatment choices. Autologous transplantation of gene‐therapy‐corrected cells is therefore investigated by numerous groups and is already under clinical trials for β‐thalassaemia, based on gene addition by lentiviral vectors (LVs). The main aim of this project was the development of personalised gene therapy (GT) for β‐thalassaemia caused by the common and severe HBBIVSI‐110 mutation, which results in missplicing of intron 1. The resulting aberrant mRNA interferes with protein expression fr
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KATIA, CAPITANI. "Genome editing for clinically relevant mutations in genetic diseases and cancer." Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1211914.

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The present thesis concerns of two sections. The first one focuses on the application of Cluster Regularly Interspaced Short Palindromic Repeats (CRISPR) system as a tool for precise genome targeting and genome editing; the association between specific endonuclease and RNA guides complementary to the DNA target allows its targeting with single-nucleotide precision. CRISPR/Cas is able to perform Double-Strand Breaks (DSBs) at a target site which are soon repaired by cellular repairing mechanism, non-homologous end joining (NHEJ) or homology-directed repair (HDR). The first part of my project a
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Förster, Susann [Verfasser], Hanspeter [Akademischer Betreuer] Herzel, Wolfgang [Akademischer Betreuer] Kemmner, and Reinhold [Akademischer Betreuer] Schäfer. "Gene expression profiling of human lymph node-positive gastric adenocarcinomas : towards personalized prognosis and therapy / Susann Förster. Gutachter: Hanspeter Herzel ; Wolfgang Kemmner ; Reinhold Schäfer." Berlin : Humboldt Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://d-nb.info/101497531X/34.

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Valls, Margarit Jordi. "Comprehensive identification and characterisation of germline structural variation within the Iberian population." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/673719.

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One of the central aims of biology and biomedicine has been the characterisation and understanding of genetic variation across humans, to answer important evolutionary questions and to explain phenotypic variability concerning the diseases. Understanding genetic variability, is key to study this relationship (through imputation and GWASs) and to translate the results into improved clinical protocols. Different initiatives have emerged around the world to systematically characterise the genetic variability of specific human populations from whole-genome sequences, usually by selecting geographi
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Vahedi, Golnaz. "An Engineering Approach Towards Personalized Cancer Therapy." 2009. http://hdl.handle.net/1969.1/ETD-TAMU-2009-08-2941.

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Cells behave as complex systems with regulatory processes that make use of many elements such as switches based on thresholds, memory, feedback, error-checking, and other components commonly encountered in electrical engineering. It is therefore not surprising that these complex systems are amenable to study by engineering methods. A great deal of effort has been spent on observing how cells store, modify, and use information. Still, an understanding of how one uses this knowledge to exert control over cells within a living organism is unavailable. Our prime objective is "Personalized Cancer T
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Books on the topic "Personalized gene therapy"

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Olga, Golubnitschaja, ed. Predictive diagnostics and personalized treatment: Dream or reality. Nova Science Publishers, 2009.

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Smalley, Keiran. Current Challenges in Personalized Cancer Medicine. Elsevier Science & Technology Books, 2012.

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Smalley, Keiran. Current Challenges in Personalized Cancer Medicine. Elsevier Science & Technology Books, 2012.

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Bakhtiar, Syeda Marriam, and Erum Dilshad, eds. Omics Technologies for Clinical Diagnosis and Gene Therapy: Medical Applications in Human Genetics. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/97898150795171220101.

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Genetic disorders have been the focus of scientists for a long time. The emergence of next-generation sequencing techniques has ushered a new era in genetics and several developments have occurred in human genetics. The scientific perspective has also been widened with omics technologies that allow researchers to analyze genetic sequences and their expression products. An integrated approach is being used not only for diagnosis but also for disease management and therapeutic purposes. This book highlights emerging areas of omics technology and its application in the diagnosis and management of
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Barker, Richard. The supply of new medicine—unlimited? Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199600663.003.0002.

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Chapter 1 describes the supply of new medical technology which exploits the huge advances we are making in bioscience, the build-up a profound understanding of how the beautiful molecular machines of the living cell actually work, and how they link together in the almost unimaginably complex system that is our body, and asks what fresh pharmaceutical innovations are on the horizon? Will gene and cell therapy reach the diseases that drugs cannot reach? Is ‘Personalized medicine’ practical? What will converging technologies—therapeutics, diagnostics, informatics, nanotechnology—bring us?
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Viles, Jill Dopf. Manufacturing My Miracle. Bloomsbury Academic, 2025. https://doi.org/10.5040/9798881846145.

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Who lives? Who dies? Who decides? One woman's quest to save her family from a rare hereditary disorder and what it means for our collective genetic future Jill Dopf Viles's genetic detective story takes readers on an extraordinary journey of scientific discovery, personal determination, and bioethical debate. From childhood, Jill knew her body was different - her muscles were weak, her tendons tight, and her body fat nearly absent. When doctors failed to diagnose her condition, she became her own researcher, diving deep into genetics in her search for answers. Nearly thirty years ago, Jill Vil
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Fehse, Boris, Ferdinand Hucho, Sina Bartfeld, et al., eds. Fünfter Gentechnologiebericht. Nomos Verlagsgesellschaft mbH & Co. KG, 2021. http://dx.doi.org/10.5771/9783748927242.

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In the ‘Fifth Gene Technology Report’, renowned experts provide an overview of current developments and their applications in the dynamically evolving research field of gene and biotechnologies. They examine, among other topics, genetic diagnostics, somatic gene therapy, the development of vaccines, stem cell and organoid research, green gene technology, synthetic biology, gene drives, genome editing, epigenetics and single cell analysis. In addition to reporting on the current state of affairs in this field, the authors also discuss society’s perception of gene technologies and ethical and le
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Genes, chromosomes, and disease: From simple traits, to complex traits, to personalized medicine. FT Press Science, 2011.

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Canli, Turhan. Neurogenethics. Edited by Turhan Canli. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199753888.013.27.

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Ethical inquiry has followed advances in biology for decades, and different fields within biology have given rise to overlapping yet distinct areas of ethical inquiry. Genethics focuses on the ethics of genetics. Neuroethics focuses on the ethics of neuroscience. The author suggests that developments in molecular psychology, in which the tools of molecular biology are applied to study behavior, bring a new confluence of factors to generate a set of new questions, unique to the combination of neuroscience and genetics: neurogenethics—the ethics of neurogenetics. The questions are unique and nov
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Book chapters on the topic "Personalized gene therapy"

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Baum, Bruce J. "Gene Therapy for Xerostomia." In Genomics, Personalized Medicine and Oral Disease. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-17942-1_15.

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Greenberger, Joel S., Michael W. Epperly, Peter Wipf, Song Li, Valerian Kagan, and Xiang Gao. "Gene Therapy for Mucositis." In Genomics, Personalized Medicine and Oral Disease. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-17942-1_16.

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YüCel, Ilyas, and Mahir Binici. "Gene Therapy in Hereditary Diseases." In Gene Therapy. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053358824.9.

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Inherited diseases are caused by mutations or genetic changes in an individual’s DNA, leading to familial inheritance patterns. These diseases can be categorized into monogenic, multifactorial, and chromosomal diseases. Understanding the genetic basis of these diseases is crucial for identifying their causes and developing genetic counseling services. Common hereditary diseases, such as cystic fibrosis and Huntington’s disease, result from specific genetic disorders and exhibit various symptoms, which can guide early diagnosis and treatment. Knowledge of genetic risk factors and inheritance mo
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Vorhies, John S., Donald D. Rao, Neil Senzer, and John Nemunaitis. "siRNA Versus shRNA for Personalized Cancer Therapy: Mechanisms and Applications." In Gene-Based Therapies for Cancer. Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-6102-0_4.

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Bhalla, Parinishtha, Anukriti Verma, Bhawna Rathi, Shivani Sharda, and Pallavi Somvanshi. "Exploring Molecular Signatures in Spondyloarthritis: A Step Towards Early Diagnosis." In Proceedings of the Conference BioSangam 2022: Emerging Trends in Biotechnology (BIOSANGAM 2022). Atlantis Press International BV, 2022. http://dx.doi.org/10.2991/978-94-6463-020-6_15.

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AbstractSpondyloarthritis is an acute inflammatory disorder of the musculoskeletal system often accompanied by pain, stiffness, bone and tissue damage. It majorly consists of ankylosing spondylitis, psoriatic arthritis and reactive arthritis. It follows a differential diagnosis pattern for demarcation between the spondyloarthritis subtypes and other arthritic subtypes such as rheumatoid arthritis, juvenile arthritis and osteoarthritis due to the heterogeneity causing gradual chronicity and complications. Presence of definite molecular markers can not only improve diagnosis efficiency but also
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Li, Yao, Lawrence Chan, Huy V. Nguyen, and Stephen H. Tsang. "Personalized Medicine: Cell and Gene Therapy Based on Patient-Specific iPSC-Derived Retinal Pigment Epithelium Cells." In Retinal Degenerative Diseases. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-17121-0_73.

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Paro, Renato, Ueli Grossniklaus, Raffaella Santoro, and Anton Wutz. "Epigenetics and Cancer." In Introduction to Epigenetics. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-68670-3_8.

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AbstractAlterations in chromatin function and epigenetic mechanisms are a hallmark of cancer. The disruption of epigenetic processes has been linked to altered gene expression and to cancer initiation and progression. Recent cancer genome sequencing projects revealed that numerous epigenetic regulators are frequently mutated in various cancers. This information has not only started to be utilized as prognostic and predictive markers to guide treatment decisions but also provided important information for the understanding of the molecular mechanisms of epigenetic regulation in both physiologic
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Grosios, Konstantina, Harald Petry, and Jacek Lubelski. "Adeno-Associated Virus Gene Therapy and Its Application to the Prevention and Personalised Treatment of Rare Diseases." In Rare Diseases. Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-9214-1_9.

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Brix, Nikko, and Kirsten Lauber. "Immune Checkpoint Inhibition and Radiotherapy in Head and Neck Squamous Cell Carcinoma: Synergisms and Resistance Mechanisms." In Critical Issues in Head and Neck Oncology. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-23175-9_2.

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AbstractImmune checkpoint inhibition has emerged as an integral part of the standard-of-care for head and neck squamous cell carcinoma (HNSCC) in recurrent and/or metastatic stages. Clinical responses are impressive but remain limited to a minority of patients. Primary resistance of never-responders is considered to derive from host- and tumor-specific characteristics, the latter comprising tumor immune checkpoint activity, immune contexture, tumor mutational burden, neo-antigen load, and others. Secondary resistance of initially responding patients in addition, appears to be driven predominan
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Wilson, James M., and Nelson A. Wivel. "Gene Therapy." In Genomic and Personalized Medicine. Elsevier, 2009. http://dx.doi.org/10.1016/b978-0-12-369420-1.00053-6.

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Conference papers on the topic "Personalized gene therapy"

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Critelli, Rosina Maria, Fabiola Milosa, Barbara Lei, et al. "Abstract A07: Gene analysis maps HCC heterogeneity and orientates personalized therapy." In Abstracts: AACR Special Conference on Developmental Biology and Cancer; November 30 - December 3, 2015; Boston, Massachusetts. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1557-3125.devbiolca15-a07.

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Rivera, Grecia C. G., Juan G. Colonna, and Marcelo Ruiz. "Discovery of Conditionally Independent Networks Among Gene Expressions in Breast Cancer Using Fast Step Graph." In Simpósio Brasileiro de Computação Aplicada à Saúde. Sociedade Brasileira de Computação - SBC, 2025. https://doi.org/10.5753/sbcas.2025.7499.

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The heterogeneity of the causes of breast cancer and these complex gene interactions that characterize this neoplasm present significant challenges to understanding and treating the disease. This study is motivated by the need to identify interconnected networks of breast cancer genes, specifically those that represent conditional independence relationships. To construct these networks, we propose the use of the Fast Step Graph algorithm, which belongs to the family of sparse, high-dimensional Gaussian Graphical Models, applied to the PAM50 gene expression dataset. This dataset was stratified
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Suchkov, Sergey. "Personalized Bringing the Promise of Personalized and Precision Medicine (PPM) to Rare and Orphan Disorder Care: The Future of PPM through the View of Biodesign-inspired Hi-Tech Philosophy, Upgraded Mentality and Global Needs of the Consumers." In World Conference on Gynecology, Obstetrics, and Pediatrics. Eurasia Conferences, 2025. https://doi.org/10.62422/978-81-981865-0-8-014.

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A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, personalized and precision medicine (PPM). The concept of PPM is becoming increasingly relevant for cancer treatment, moving from the ‘one-size-fits-all’ standard therapy to a more personalized scheme guided by molecular diagnostics. A comprehensive molecular tumor analysis integrating a combination of NGS methods including whole-exome (WES), whole-genome (WGS) and transcriptome sequencing (RNAseq) offers the best chance for personalizing cancer care, enlarging the scope of therapy
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Inyushkin, A. A., T. S. Isakova, M. N. Inyushkina, P. S. Kudasheva, and A. N. Inyushkin. "Private Law Aspects of Personalized Medicine: Digitalization, Big Data, Artificial Intelligence." In International scientific and practical conference “Smart cities and sustainable development of regions” (SMARTGREENS 2024). Crossref, 2025. https://doi.org/10.63550/iceip.2025.1.1.041.

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This study examines the current state and prospects for improving the regulatory framework in the field of personalized medical care in the context of the development of advanced technologies and the implementation of new methods of providing high-tech specialized medical care. A system for regulating the provision of specialized medical care is being identified and established through the implementation of digital technologies and telemedicine. The study evaluates the optimization of the regulatory framework in the field of gene therapy and trends in the consolidation of legislation in the fi
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Tsydenova, I. A., V. A. Markovich, E. A. Kravtsova, D. S. Dolgasheva, M. M. Tsyganov, and N. V. Litviakov. "COMBINED TREATMENT OF PATIENTS WITH STAGE IV GASTRIC CANCER BASED ON ASSESSMENT OF CHEMOSENSITIVITY AND ABC TRANSPORTER GENE EXPRESSION LEVELS." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-390.

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Metastatic tumours are known to have heterogeneity between primary and metastatic sites. This type of heterogeneity is the cause of low efficacy of therapy. In this regard, comparative analysis of ABC-transporter gene expression and chemosensitivity genes will make it possible to determine the resistance and sensitivity of tumours to therapy and provide a basis for a personalised treatment approach.
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Foy, Susan, Kyle Jacoby, Daniela Bota, et al. "1478 A phase I study of personalized adoptive TCR T cell therapy in patients with solid tumors: safety, efficacy, and T cell trafficking to tumors of non-virally gene edited T cells." In SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.1478.

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Jurišić, Vladimir. "POSSIBILITIES OF CYTOKINE DETERMINATION AND THEIR ANALYSIS IN VARIOUS TISSUES." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac,, 2021. http://dx.doi.org/10.46793/iccbi21.089j.

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Cytokines are small proteins that participate in many interactions between cells of the immune system as well as between many tissue cells including tumors. Currently, there is no universal classification of cytokines and they can be analyzed based on the cells that produce them or based on the type of activity. Cytokines have been studied for many years in medicine firstly in cancer patients in serum, but also in many other diseases including inflammation or other autoimmune diseases or other pathological conditions. Cytokines are still being discovered, and for many of them the structure, bi
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Radović, Milan. "Current and future prospects in treatment of pulmonary hypertension." In 7 th International Congress of Cardionephrology - KARNEF 2025. Punta Niš, 2025. https://doi.org/10.46793/karnef25.127r.

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In recent years, great progress has been made in understanding the cellular and molecular mechanisms driving pulmonary vascular remodeling in various forms of pulmonary hypertension (PH), including pulmonary arterial hypertension (PAH), pulmonary hypertension associated with left heart disease, pulmonary hypertension associated with chronic disease lungs and hypoxemia, and chronic thromboembolic pulmonary hypertension. Nevertheless, survival rates for all these forms of PH remain unsatisfactory, highlighting the crucial need to implement innovative scientific knowledge more effectively into ex
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Suchkov, Sergey. "Strategies for integrating Personalized and Precision Medicine (PPM) into Reproductive Healthcare Practice to Secure the Human Healthcare, Wellness and Biosafety: Forging the Grand Consensus." In World Conference on Gynecology, Obstetrics, and Pediatrics. Eurasia Conferences, 2025. https://doi.org/10.62422/978-81-981865-0-8-002.

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A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, personalized and precision medicine (PPM). Meanwhile, the era of genomics-based medicine and thus genomics biomarkers promises to provide molecular tests that will permit PPM as applicable to personalized and precision oncology (PPO). Using the PCL-5 questionnaire and according to the DSM-5 criteria for PTSD, 20% were To achieve the implementation of PPM-guided oncology concept, it is necessary to create a funda-mentally new strategy based upon the subclinical recognition of biopre
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Nascimento, Renan Gomes do. "AN IN SÍLICO ANALYSIS DETECTED MEMBERS OF THE PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY B AS POTENTIAL PROGNOSTIC BIOMARKERS IN PATIENTS WITH BREAST CANCER." In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2034.

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Objectives: Despite advances in the molecular classification of breast cancer, our understanding of the pathophysiology of the disease is still limited mainly due to the considerable intratumoral heterogeneity. Thus, hundreds of other candidates for biomarkers are being investigated and studied for possible implications for diagnosis, prognosis, and personalized therapy. In this context, members of the Pleckstrin homology-like domain family B (PHLDB), which is composed of three genes located on different chromosomes: PHLDB1 (11q23.3), PHLDB2 (3q13.2), and PHLDB3 (19q13.3), are under investigat
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