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Journal articles on the topic 'Peste des petits ruminants virus (PPRV)'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Schulz, Claudia, Christine Fast, Ulrich Wernery, et al. "Camelids and Cattle Are Dead-End Hosts for Peste-des-Petits-Ruminants Virus." Viruses 11, no. 12 (2019): 1133. http://dx.doi.org/10.3390/v11121133.

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Peste-des-petits-ruminants virus (PPRV) causes a severe respiratory disease in small ruminants. The possible impact of different atypical host species in the spread and planed worldwide eradication of PPRV remains to be clarified. Recent transmission trials with the virulent PPRV lineage IV (LIV)-strain Kurdistan/2011 revealed that pigs and wild boar are possible sources of PPRV-infection. We therefore investigated the role of cattle, llamas, alpacas, and dromedary camels in transmission trials using the Kurdistan/2011 strain for intranasal infection and integrated a literature review for a pr

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Mdetele, Daniel Pius, Erick Komba, Misago Dimson Seth, Gerald Misinzo, Richard Kock, and Bryony Anne Jones. "Review of Peste des Petits Ruminants Occurrence and Spread in Tanzania." Animals 11, no. 6 (2021): 1698. http://dx.doi.org/10.3390/ani11061698.

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Peste des petits ruminants (PPR) is an important transboundary animal disease of domestic small ruminants, camels, and wild artiodactyls. The disease has significant socio-economic impact on communities that depend on livestock for their livelihood and is a threat to endangered susceptible wild species. The aim of this review was to describe the introduction of PPR to Tanzania and its subsequent spread to different parts of the country. On-line databases were searched for peer-reviewed and grey literature, formal and informal reports were obtained from Tanzanian Zonal Veterinary Investigation

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Akanbi, Olatunde Babatunde, Kati Franzke, Adeyinka Jeremy Adedeji, Reiner Ulrich, and Jens Peter Teifke. "Peste Des Petits Ruminants Virus and Goatpox Virus Co-Infection in Goats." Veterinary Pathology 57, no. 4 (2020): 550–53. http://dx.doi.org/10.1177/0300985820926954.

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Infection of small ruminants with peste des petits ruminants virus (PPRV) and goatpox virus (GTPV) are endemic and can have devastating economic consequences in Asia and Africa. Co-infection with these viruses have recently been reported in goats and sheep in Nigeria. In this study, we evaluated samples from the lips of a red Sokoto goat, and describe co-infection of keratinocytes with PPRV and GTPV using histopathology and transmission electron microscopy. Eosinophilic cytoplasmic inclusion bodies were identified histologically, and ultrastructural analysis revealed numerous large cytoplasmic

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4

Berhe, G., C. Minet, C. Le Goff, et al. "Development of a Dual Recombinant Vaccine To Protect Small Ruminants against Peste-des-Petits-Ruminants Virus and Capripoxvirus Infections." Journal of Virology 77, no. 2 (2003): 1571–77. http://dx.doi.org/10.1128/jvi.77.2.1571-1577.2003.

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ABSTRACT A recombinant capripoxvirus vaccine containing a cDNA of the peste-des-petits-ruminants virus (PPRV) fusion protein gene was constructed. A quick and efficient method was used to select a highly purified recombinant virus clone. A trial showed that a dose of this recombinant as low as 0.1 PFU protected goats against challenge with a virulent PPRV strain.

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Ahmed, Sahar, Wafaa Abd El Wahab Hosny, Mervat Mahmoud, and Mohammed Abd El-Fatah Mahmoud. "Isolation and identification of peste des petits ruminants virus from goats in Egyptian governorates." Veterinary World 14, no. 4 (2021): 926–32. http://dx.doi.org/10.14202/vetworld.2021.926-932.

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Background and Aim: The peste des petits ruminants (PPR) is a highly contagious disease of small ruminants which negatively affects animal production and the socioeconomic status of farmers. Peste des petits ruminants virus (PPRV) encodes eight proteins, with the viral fusion protein (F) playing a role in virus virulence and stimulating an effective protective immune response. This study aimed to isolate and complete the identification of PPRV circulating in goats in different Egyptian governorates and perform molecular characterization of the PPRV F gene. Materials and Methods: Samples were c

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Murr, Magdalena, Bernd Hoffmann, Christian Grund, Angela Römer-Oberdörfer, and Thomas C. Mettenleiter. "A Novel Recombinant Newcastle Disease Virus Vectored DIVA Vaccine against Peste des Petits Ruminants in Goats." Vaccines 8, no. 2 (2020): 205. http://dx.doi.org/10.3390/vaccines8020205.

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Peste des petits ruminants virus (PPRV, species: small ruminant morbillivirus) is the causative agent of the eponymous notifiable disease, the peste des petits ruminants (PPR) in wild and domestic sheep and goats. Mortality rates vary between 50% and 100%, causing significant losses of estimated 1.5 to 2 billion US Dollars per year. Live-attenuated PPRV vaccine strains are used in the field for disease prevention, but the application of a more thermostable vaccine enabling differentiation between infected and vaccinated animals (DIVA) would be highly desirable to achieve the goal of global dis

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7

Zhu, Zixiang, Xiaocui Zhang, Gulizhati Adili, et al. "Genetic Characterization of a Novel Mutant of Peste Des Petits Ruminants Virus Isolated fromCapra ibexin China during 2015." BioMed Research International 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/7632769.

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Peste des petits ruminants virus (PPRV) is the causative agent of peste des petits ruminants (PPR). The spread of PPR often causes severe economic losses. Therefore, special attention should be paid to the surveillance of PPR emergence, spread, and geographic distribution. Here we describe a novel mutant of PPRV China/XJBZ/2015 that was isolated fromCapra ibexin Xinjiang province in China 2015. The sequence analysis and phylogenetic assessment indicate that China/XJBZ/2015 belongs to lineage IV, being closely related to China/XJYL/2013 strain. Interestingly, the V protein sequence of China/XJB

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8

Yan, Banadyga, Zhao, et al. "Peste des Petits Ruminants Virus-Like Particles Induce a Potent Humoral and Cellular Immune Response in Goats." Viruses 11, no. 10 (2019): 918. http://dx.doi.org/10.3390/v11100918.

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Peste des petits ruminants is a highly contagious acute or subacute disease of small ruminants caused by the peste des petits ruminants virus (PPRV), and it is responsible for significant economic losses in animal husbandry. Vaccination represents the most effective means of controlling this disease, with virus-like particle (VLP) vaccines offering promising vaccine candidates. In this study, a PPRV VLP-based vaccine was developed using a baculovirus expression system, allowing for the simultaneous expression of the PPRV matrix (M), hemagglutinin (H), fusion (F) and nucleocapsid (N) proteins i

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Dhar, Pronab, B. P. Sreenivasa, Thomas Barrett, Mandy Corteyn, R. P. Singh, and S. K. Bandyopadhyay. "Recent epidemiology of peste des petits ruminants virus (PPRV)." Veterinary Microbiology 88, no. 2 (2002): 153–59. http://dx.doi.org/10.1016/s0378-1135(02)00102-5.

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10

Kinimi, Edson, Serge Muyldermans, Cécile Vincke, et al. "Development of Nanobodies Targeting Peste des Petits Ruminants Virus: The Prospect in Disease Diagnosis and Therapy." Animals 11, no. 8 (2021): 2206. http://dx.doi.org/10.3390/ani11082206.

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Peste des petits ruminants virus (PPRV) causes a highly devastating disease, peste des petits ruminants (PPR) of sheep and goats, that threatens food security, small ruminant production, and the conservation of wild small ruminants in many developing countries, especially in Africa. Robust serological and molecular diagnostic tools are available to detect PPRV infection, but they were mainly developed for domestic sheep and goats. The presence of a wide host range for PPRV does present serological diagnostic challenges. New innovative diagnostic tools are needed to detect PPRV in atypical host

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Li, Pengfei, Zixiang Zhu, Xiangle Zhang, et al. "The Nucleoprotein and Phosphoprotein of Peste des Petits Ruminants Virus Inhibit Interferons Signaling by Blocking the JAK-STAT Pathway." Viruses 11, no. 7 (2019): 629. http://dx.doi.org/10.3390/v11070629.

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Peste des petits ruminants virus (PPRV) is associated with global peste des petits ruminants resulting in severe economic loss. Peste des petits ruminants virus dampens host interferon-based signaling pathways through multiple mechanisms. Previous studies deciphered the role of V and C in abrogating IFN-β production. Moreover, V protein directly interacted with signal transducers and activators of transcription 1 (STAT1) and STAT2 resulting in the impairment of host IFN responses. In our present study, PPRV infection inhibited both IFN-β- and IFN-γ-induced activation of IFN-stimulated response

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Choi, Kang-Seuk, Jin-Ju Nah, Young-Joon Ko, Shien-Young Kang, and Nam-In Jo. "Rapid Competitive Enzyme-Linked Immunosorbent Assay for Detection of Antibodies to Peste des Petits Ruminants Virus." Clinical Diagnostic Laboratory Immunology 12, no. 4 (2005): 542–47. http://dx.doi.org/10.1128/cdli.12.4.542-547.2005.

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ABSTRACT Peste des petits ruminants (PPR) is a contagious viral disease of small ruminants that is of economic importance in Africa, the Middle East, and Asia. We developed a rapid competitive enzyme-linked immunosorbent assay (rapid c-ELISA) for the diagnosis and surveillance of PPR. This assay detects PPR virus (PPRV) antibodies in serum samples by quantifying the amount of monoclonal antibody (MAb) P-3H12 after 30 min of incubation of a serum-MAb conjugate mixture on plates coated with a PPRV recombinant nucleocapsid protein (rPPRV-N). We tested 249 PPRV-positive serum samples and 733 PPRV-

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Hemida, Maged Gomaa, and Hussain Mohammed Al-Ghadeer. "Evidence of Peste des petits Ruminants’ Virus in Dromedary Camels in the Kingdom of Saudi Arabia between 2014 and 2016." Veterinary Medicine International 2019 (November 12, 2019): 1–4. http://dx.doi.org/10.1155/2019/4756404.

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Infection with the Peste des petits ruminants virus (PPRV) is a highly devastating viral infection of small ruminants. Dromedary camels live in close proximity of small ruminants in Arabian Peninsula (AP) and many other regions in the world. Little is known about the reasons behind continuous PPRV emergence in Saudi Arabia (KSA). Our objective was to test some dromedary camel population across the kingdom for the presence of specific PPRV antibodies. Our results show detection of specific PPRV antibodies (2.92%) in sera of tested dromedary camels from the eastern and south regions of the KSA.

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Fournié, Guillaume, Agnès Waret-Szkuta, Anton Camacho, Laike M. Yigezu, Dirk U. Pfeiffer, and François Roger. "A dynamic model of transmission and elimination of peste des petits ruminants in Ethiopia." Proceedings of the National Academy of Sciences 115, no. 33 (2018): 8454–59. http://dx.doi.org/10.1073/pnas.1711646115.

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Peste des petits ruminants (PPR), a devastating viral disease of sheep and goats, has been targeted by the global community for eradication within the next 15 years. Although an efficacious attenuated live vaccine is available, the lack of knowledge about the transmission potential of PPR virus (PPRV) may compromise eradication efforts. By fitting a metapopulation model simulating PPRV spread to the results of a nationwide serological survey in Ethiopia, we estimated the level of viral transmission in an endemic setting and the vaccination coverage required for elimination. Results suggest tha

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15

Dundon, William G., Adama Diallo, and Giovanni Cattoli. "Peste des petits ruminants in Africa: a review of currently available molecular epidemiological data, 2020." Archives of Virology 165, no. 10 (2020): 2147–63. http://dx.doi.org/10.1007/s00705-020-04732-1.

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Abstract Small ruminants (e.g., sheep and goats) contribute considerably to the cash income and nutrition of small farmers in most countries in Africa and Asia. Their husbandry is threatened by the highly infectious transboundary viral disease peste des petits ruminants (PPR) caused by peste-des-petits-ruminants virus (PPRV). Given its social and economic impact, PPR is presently being targeted by international organizations for global eradication by 2030. Since its first description in Côte d’Ivoire in 1942, and particularly over the last 10 years, a large amount of molecular epidemiological

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Mahapatra, M., S. Parida, M. D. Baron, and T. Barrett. "Matrix protein and glycoproteins F and H of Peste-des-petits-ruminants virus function better as a homologous complex." Journal of General Virology 87, no. 7 (2006): 2021–29. http://dx.doi.org/10.1099/vir.0.81721-0.

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The matrix (M) protein of paramyxoviruses forms an inner coat to the viral envelope and serves as a bridge between the surface glycoproteins (F and H) and the ribonucleoprotein core. Previously, a marker vaccine (RPV-PPRFH) was produced for the control of peste des petits ruminants (PPR) disease, where the F and H genes of Rinderpest virus (RPV) were replaced with the equivalent genes from Peste-des-petits-ruminants virus (PPRV); however, this virus grew poorly in tissue culture. The poor growth of the RPV-PPRFH chimeric virus was thought to be due to non-homologous interaction of the surface

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Aziz-ul-Rahman, Muhammad Abubakar, Muhammad Hidayat Rasool, et al. "Evaluation of Risk Factors for Peste des Petits Ruminants Virus in Sheep and Goats at the Wildlife-Livestock Interface in Punjab Province, Pakistan." BioMed Research International 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/7826245.

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Peste des petits ruminants virus (PPRV) is causing infectious disease with high morbidity and mortality rate in domestic and wild small ruminants of Pakistan with valuable economical losses. The present study was carried out to investigate risk factors of PPRV in domestic small ruminants which were present in the vicinity of wildlife parks. A total of 265 sera samples (27 wild ruminants and 238 domesticated small ruminants) from apparently healthy animals from two different wildlife parks were collected and analysed for PPRV antibodies. Also, 20 nasal swabs from domestic small ruminants showin

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Hemida, Maged Gomaa, Hussain Mohammed Alghadeer, Mohammed Alhammadi, and Sayed Ali. "Prevalence and molecular characterization of some circulating strains of the peste-des-petits-ruminants virus in Saudi Arabia between 2014–2016." PeerJ 8 (May 27, 2020): e9035. http://dx.doi.org/10.7717/peerj.9035.

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Background The peste-des-petits-ruminants virus (PPRV) is a highly devastating virus of small ruminants in many parts of the world, including the Kingdome of Saudi Arabia. Therefore, our objectives were (1) to conduct a molecular prevalence study of PPRV in sheep and goat across the KSA and (2) to isolate and identify currently circulating PPRV lineages. Swabs and tissue specimens were collected from 97 herds suspected to be infected with PPRV across the Kingdome of Saudi Arabia (KSA). Testing for the presence of the virus was done by the real-time PCR. Confirmation of the identity of the reac

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Jones, Bryony A., Mana Mahapatra, Daniel Mdetele, et al. "Peste des Petits Ruminants Virus Infection at the Wildlife–Livestock Interface in the Greater Serengeti Ecosystem, 2015–2019." Viruses 13, no. 5 (2021): 838. http://dx.doi.org/10.3390/v13050838.

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Peste des petits ruminants (PPR) is a viral disease of goats and sheep that occurs in Africa, the Middle East and Asia with a severe impact on livelihoods and livestock trade. Many wild artiodactyls are susceptible to PPR virus (PPRV) infection, and some outbreaks have threatened endangered wild populations. The role of wild species in PPRV epidemiology is unclear, which is a knowledge gap for the Global Strategy for the Control and Eradication of PPR. These studies aimed to investigate PPRV infection in wild artiodactyls in the Greater Serengeti and Amboseli ecosystems of Kenya and Tanzania.

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Fernandez Aguilar, Xavier, Mana Mahapatra, Mattia Begovoeva, et al. "Peste des Petits Ruminants at the Wildlife–Livestock Interface in the Northern Albertine Rift and Nile Basin, East Africa." Viruses 12, no. 3 (2020): 293. http://dx.doi.org/10.3390/v12030293.

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In the recent past, peste des petits ruminants (PPR) emerged in East Africa causing outbreaks in small livestock across different countries, with evidences of spillover to wildlife. In order to understand better PPR at the wildlife–livestock interface, we investigated patterns of peste des petits ruminants virus (PPRV) exposure, disease outbreaks, and viral sequences in the northern Albertine Rift. PPRV antibodies indicated a widespread exposure in apparently healthy wildlife from South Sudan (2013) and Uganda (2015, 2017). African buffaloes and Uganda kobs <1-year-old from Queen Elizabeth

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Prajapati, Meera, Niyokwishimira Alfred, Yongxi Dou, et al. "Host Cellular Receptors for the Peste des Petits Ruminant Virus." Viruses 11, no. 8 (2019): 729. http://dx.doi.org/10.3390/v11080729.

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Peste des Petits Ruminant (PPR) is an important transboundary, OIE-listed contagious viral disease of primarily sheep and goats caused by the PPR virus (PPRV), which belongs to the genus Morbillivirus of the family Paramyxoviridae. The mortality rate is 90–100%, and the morbidity rate may reach up to 100%. PPR is considered economically important as it decreases the production and productivity of livestock. In many endemic poor countries, it has remained an obstacle to the development of sustainable agriculture. Hence, proper control measures have become a necessity to prevent its rapid spread

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NIEDBALSKI, WIESŁAW, ANDRZEJ FITZNER, KRZYSZTOF BULENGER, and ANDRZEJ KĘSY. "Recent advances in the laboratory diagnosis of peste des petits ruminants." Medycyna Weterynaryjna 77, no. 05 (2021): 226–31. http://dx.doi.org/10.21521/mw.6536.

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Peste des petits ruminants (PPR) is a highly contagious and economically important, viral disease of small ruminants caused by the peste des petits ruminants virus (PPRV), which belongs to the genus Morbilivirus in the family Paramyxoviridae. PPR control is achieved mostly through vaccination and/or slaughter of susceptible animals coupled with clinical or laboratory-based diagnosis. Since clinical signs of PPR are not disease-specific and clinical diagnostics is not reliable, it should be confirmed by laboratory testing. Laboratory confirmation of clinical suspicions is made by detection of P

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Conteh, AM, NM Kallon, DH Jojo, Sesay AR., and Bundu WT. "SURVEY ON SMALL RUMINANT PRODUCTION AGAINST PESTE DES PETITS RUMINANT IN MOYAMBA AND KAILAHUN DISTRICTS, SIERRA LEONE." International Journal of Research -GRANTHAALAYAH 8, no. 2 (2020): 243–53. http://dx.doi.org/10.29121/granthaalayah.v8.i2.2020.215.

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Goats and sheep production which significantly contributes to improving nutritional status, economic growth and socio-cultural practices in the rural settings of Sierra Leone are faced with several challenges. The survey on Peste des Petits Ruminants Virus (PPRV) was carried out to investigate the: current status of small ruminant production, and the presence of antibodies against PPRV. Information was obtained through Focus Group Discussion in the respondents’ local dialects from 150 participants. From the results obtained, 58.7% and 41.7% of the respondents were male and female while 77.3% a

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Rume, Veronica Nwankpa, William G. Dundon, Gurja Belay, et al. "Molecular epidemiological update of Peste des Petits Ruminants virus (PPRV) in Ethiopia." Veterinary Microbiology 235 (August 2019): 229–33. http://dx.doi.org/10.1016/j.vetmic.2019.07.006.

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Baron, Michael D., Bouna Diop, Felix Njeumi, Brian J. Willett, and Dalan Bailey. "Future research to underpin successful peste des petits ruminants virus (PPRV) eradication." Journal of General Virology 98, no. 11 (2017): 2635–44. http://dx.doi.org/10.1099/jgv.0.000944.

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Chazya, R., J. B. Muma, K. K. Mwacalimba, E. Karimuribo, E. Mkandawire, and M. Simuunza. "A Qualitative Assessment of the Risk of Introducing Peste des Petits Ruminants into Northern Zambia from Tanzania." Veterinary Medicine International 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/202618.

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A qualitative risk assessment was performed to evaluate the risk of introducing Peste des petits ruminants virus into northern Zambia from Tanzania via live goat trade. Data was collected during a mission to Tanzania and northern Zambia and also from literature and interviews with experts. The risk of PPRV introduction was evaluated as a function of the probability of hazard (PPRV) release, exposure of susceptible hosts, and the consequences of spread using the following parameters: prevalence of infection, volume of trade, C-ELISA and quarantine screening missing an infected animal, PPRV viab

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Holzer, Barbara, Sophia Hodgson, Nicola Logan, Brian Willett, and Michael D. Baron. "Protection of Cattle against Rinderpest by Vaccination with Wild-Type but Not Attenuated Strains of Peste des Petits Ruminants Virus." Journal of Virology 90, no. 10 (2016): 5152–62. http://dx.doi.org/10.1128/jvi.00040-16.

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ABSTRACTAlthough rinderpest virus (RPV) has been eradicated in the wild, efforts are still continuing to restrict the extent to which live virus is distributed in facilities around the world and to prepare for any reappearance of the disease, whether through deliberate or accidental release. In an effort to find an alternative vaccine which could be used in place of the traditional live attenuated RPV strains, we have determined whether cattle can be protected from rinderpest by inoculation with vaccine strains of the related morbillivirus, peste des petits ruminants virus (PPRV). Cattle were

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Jarikre, Theophilus Aghogho, Jeremiah Olalekan Taiwo, Benjamin Obukowho Emikpe, and Stephen Owarioro Akpavie. "Protective effect of intranasal peste des petits ruminants virus and bacterin vaccinations: Clinical, hematological, serological, and serum oxidative stress changes in challenged goats." July-2019 12, no. 7 (2019): 945–50. http://dx.doi.org/10.14202/vetworld.2019.945-950.

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Background and Aim: The current vaccination for peste des petits ruminants virus (PPRV) is stalled by myriad challenges and continuous endemicity of pneumonia due to fulminant bacterial complication in goats. The present study evaluated the protective effect of intranasal PPRV linage 1 and bacterine vaccinations. Materials and Methods: Twelve West African Dwarf (WAD) goats aged 6 months were randomly grouped and vaccinated within 2 weeks using a combination of PPRV lineage 1 vaccine (Nig/75), and bacterin from Mannheimia haemolytica (Mh) or Pasteurella multocida intranasally. The goats were ob

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Servan de Almeida, Renata, Djénéba Keita, Geneviève Libeau, and Emmanuel Albina. "Control of ruminant morbillivirus replication by small interfering RNA." Journal of General Virology 88, no. 8 (2007): 2307–11. http://dx.doi.org/10.1099/vir.0.82981-0.

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Peste-des-petits-ruminants virus (PPRV) and rinderpest virus (RPV) are two morbilliviruses of economic relevance in African and Asian countries. Although efficient vaccines are available for both diseases, they cannot protect the animals before 14 days post-vaccination. In emergencies, it would be desirable to have efficient therapeutics for virus control. Here, two regions are described in the nucleocapsid genes of PPRV and RPV that can be targeted efficiently by synthetic short interfering RNAs (siRNAs), resulting in a >80 % reduction in virus replication. The effects of siRNAs on the pro

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Mahapatra, Howson, Fowler, et al. "Rapid Detection of Peste des Petits Ruminants Virus (PPRV) Nucleic Acid Using a Novel Low-Cost Reverse Transcription Loop-Mediated Isothermal Amplification (RT-LAMP) Assay for Future Use in Nascent PPR Eradication Programme." Viruses 11, no. 8 (2019): 699. http://dx.doi.org/10.3390/v11080699.

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Peste des petits ruminants (PPR) is a disease of small ruminants caused by peste des petits ruminants virus (PPRV), and is endemic in Asia, the Middle East and Africa. Effective control combines the application of early warning systems, accurate laboratory diagnosis and reporting, animal movement restrictions, suitable vaccination and surveillance programs, and the coordination of all these measures by efficient veterinary services. Molecular assays, including conventional reverse transcription-polymerase chain reaction (RT-PCR) and real-time RT-PCR (RT-qPCR) have improved the sensitivity and

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Parida, Satya, Madhuchhanda Mahapatra, Sai Kumar, et al. "Rescue of a chimeric rinderpest virus with the nucleocapsid protein derived from peste-des-petits-ruminants virus: use as a marker vaccine." Journal of General Virology 88, no. 7 (2007): 2019–27. http://dx.doi.org/10.1099/vir.0.82913-0.

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The nucleocapsid (N) protein of all morbilliviruses has a highly conserved central region that is thought to interact with and encapsidate the viral RNA. The C-terminal third of the N protein is highly variable among morbilliviruses and is thought to be located on the outer surface and to be available to interact with other viral proteins such as the phosphoprotein, the polymerase protein and the matrix protein. Using reverse genetics, a chimeric rinderpest virus (RPV)/peste-des-petits-ruminants virus (PPRV) was rescued in which the RPV N gene open reading frame had been replaced with that of

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Altaf, Imran, Faryal Ashraf, Muhammad Ashraf, et al. "Evaluation of the cytotoxic and antiviral effects of ethanol extract of three Opuntia species of Peste des Petits ruminant virus." Tropical Journal of Pharmaceutical Research 19, no. 10 (2020): 2123–28. http://dx.doi.org/10.4314/tjpr.v19i10.16.

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Purpose: To assess in vitro the virocidal effects of different species of cactus plant on the lethal action of Peste des petits virus (PPRV).Method: Ethanol extracts of different cactus plants were obtained. A serial twofold dilution of the extracts was prepared. Cytotoxic and antiviral activities were examined through MTT assay at various concentrations. Vero cell lines were grown in 96 well plates up to an 80 % confluent monolayer. The plates were divided into two groups, one for antiviral and the other for cytotoxicity activity. The cells were exposed to various concentrations of the ethano

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Li, Lingxia, Jinyan Wu, Dan Liu, et al. "Transcriptional Profiles of Murine Bone Marrow-Derived Dendritic Cells in Response to Peste des Petits Ruminants Virus." Veterinary Sciences 6, no. 4 (2019): 95. http://dx.doi.org/10.3390/vetsci6040095.

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Background: Peste des petits ruminants virus (PPRV) is the causative agent of PPR, which can cause an acute, highly contagious and fatal disease of sheep and goats, resulting in significant economic losses for commercial animal husbandry due to its high mortality and morbidity. As professional antigen-presenting cells, dendritic cells (DCs) play a unique role in innate immunity. This study aimed to gain a deeper understanding of the transcriptional response of bone marrow-derived dendritic cells (BMDCs) stimulated with PPRV. Results: Transcriptional profiling was performed using RNA sequencing

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Bailey, Dalan, Louisa S. Chard, Pradyot Dash, Tom Barrett, and Ashley C. Banyard. "Reverse genetics for peste-des-petits-ruminants virus (PPRV): Promoter and protein specificities." Virus Research 126, no. 1-2 (2007): 250–55. http://dx.doi.org/10.1016/j.virusres.2007.01.015.

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Dundon, W. G., C. Adombi, A. Waqas, et al. "Full genome sequence of a peste des petits ruminants virus (PPRV) from Ghana." Virus Genes 49, no. 3 (2014): 497–501. http://dx.doi.org/10.1007/s11262-014-1109-1.

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NIEDBALSKI, WIESŁAW. "Occurrence of peste des petits ruminants and its increasing threat to Europe." Medycyna Weterynaryjna 75, no. 02 (2019): 6209–2019. http://dx.doi.org/10.21521/mw.6209.

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Peste des petits ruminants (PPR) is a highly contagious disease of small ruminants that leads to high morbidity and mortality, and thereby results in devastating economic consequences to the livestock industry. It is caused by the PPR virus (PPRV), which belongs to the genus Morbilivirus in the family Paramyxoviridae. PPR was first recorded in early 1942 in Ivory Coast, West Africa. In the following years, the disease extended its distribution to other parts of the world and now circulates throughout Northern, Eastern and West Africa, as well as Asia – in particular, China, Central Asia, Euras

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Choi, Kang-Seuk, Jin-Ju Nah, Young-Joon Ko, Shien-Young Kang, Kyoung-Jin Yoon, and Nam-In Jo. "Antigenic and Immunogenic Investigation of B-Cell Epitopes in the Nucleocapsid Protein of Peste des Petits Ruminants Virus." Clinical Diagnostic Laboratory Immunology 12, no. 1 (2005): 114–21. http://dx.doi.org/10.1128/cdli.12.1.114-121.2005.

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ABSTRACT Attempts were made to identify and map epitopes on the nucleocapsid (N) protein of peste des petits ruminants virus (PPRV) (Nigeria75/1 strain) using seven monoclonal antibodies (MAbs) and deletion mutants. At least four antigenic domains (A-I, A-II, C-I, and C-II) were identified using the MAbs. Domains A-I (MAb 33-4) and A-II (MAbs 38-4, P-3H12, and P-13A9) were determined to be located on the amino-terminal half (amino acids [aa] 1 to 262), and domains C-I (P-14C6) and C-II (P-9H10 and P-11A6) were within the carboxy-terminal region (aa 448 to 521). Nonreciprocal competition betwee

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SAIT, A., and S. B. DAGALP. "Molecular analysis of Peste des Petits Ruminants Virus from outbreak in Turkey during 2010-2012." Journal of the Hellenic Veterinary Medical Society 70, no. 3 (2019): 1617. http://dx.doi.org/10.12681/jhvms.21784.

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The aim of the study is to determine the epizootiology of Peste des petits ruminants (PPR) in Turkey during 2010-2012, using molecular genotyping. Samples of blood (n=193), swab (n=7) and tissue (n=374) were collected from sheep (n=473) and goats (n=101) suspected of having PPRV infection from an outbreak in 50 provinces of Turkey during 2010–2012. These samples (n=574) were tested using reverse transcription polymerase chain reaction (RT-PCR) and real-time reverse transcriptionpolymerase chain reaction (RT-qPCR) targeting selected parts of the fusion (F) and the nucleocapsid (N) genes. Positi

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Baydar, Ersoy, Abdurrauf Yuce, Metin Gurcay, and Omer Kizil. "The Antioxidant Status and Biochemical Parameters in Kid Goats Naturally Infected with Peste Des Petits Ruminants Virus." Acta Scientiae Veterinariae 46, no. 1 (2018): 8. http://dx.doi.org/10.22456/1679-9216.81812.

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Background: Peste des petits ruminants (PPR) is an acute and highly contagious viral disease of small ruminants. The disease is high economical importance because of the high mortality rate. Oxidative stress is an active field of research in small ruminant medicine and has been implicated in numerous disease processes including sepsis, mastitis, acidosis, enteritis, pneumonia, respiratory, and joint diseases. Compared to human medicine, only a limited number of conditions have been investigated in regard to the effects of oxidative stress in small ruminants. The aim of this study was to determ

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Eloiflin, Roger-junior, Marie Boyer, Olivier Kwiatek, et al. "Evolution of Attenuation and Risk of Reversal in Peste des Petits Ruminants Vaccine Strain Nigeria 75/1." Viruses 11, no. 8 (2019): 724. http://dx.doi.org/10.3390/v11080724.

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Peste des Petits Ruminants (PPR) is a highly infectious disease caused by a virus of the Morbillivirus genus. The current PPR eradication effort relies mainly on the implementation of massive vaccination campaigns. One of the most widely used PPR vaccines is the Nigeria 75/1 strain obtained after attenuation by 75 serial passages of the wild type isolate in cell cultures. Here we use high throughput deep sequencing of the historical passages that led to the Nigeria 75/1 attenuated strain to understand the evolution of PPRV attenuation and to assess the risk of reversal in different cell types.

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Libeau, Geneviève, J. T. Saliki, and Adama Diallo. "Caractérisation d'anticorps monoclonaux dirigés contre les virus de la peste bovine et de la peste des petits ruminants : identification d'épitopes conservés ou de spécificité stricte sur la nucléoprotéine." Revue d’élevage et de médecine vétérinaire des pays tropicaux 50, no. 3 (1997): 181–90. http://dx.doi.org/10.19182/remvt.9567.

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Vingt-neuf anticorps monoclonaux (ACM) dirigés contre les souches virales vaccinales RPV-RBOK et RPVL de peste bovine (RPV) et la souche PPRV NIG 75/3 de la peste des petits ruminants (PPRV) ont été caractérisés par radioimmunoprécipitation (RIPA), immunofluorescence ((FI) et immunoenzymologie (ELISA). Vingt-sept d'entre eux étaient dirigés contre la nucléoprotéine (N); deux ACM étaient spécifiques de la protéine de fusion (F) et de la protéine de matrice (M) du virus homologue. Pour ceux qui n'étaient pas précipitants, la réactivité au regard de la protéine de structure était confirmée par (F

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Omani, R. N., G. C. Gitao, J. Gachohi, et al. "Peste Des Petits Ruminants (PPR) in Dromedary Camels and Small Ruminants in Mandera and Wajir Counties of Kenya." Advances in Virology 2019 (March 4, 2019): 1–6. http://dx.doi.org/10.1155/2019/4028720.

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A study was conducted to determine the presence of Peste des petits ruminants (PPR) in camel population kept together with small ruminants in Isiolo, Mandera, Marsabit, and Wajir counties of Kenya. This was done in the wake of a disease with unknown etiology “Camel Sudden Death Syndrome” camels in the horn of Africa. Thirty-eight (38) samples, 12, 8, 15, and 3 samples, were collected from Mandera, Wajir, Isiolo, and Marsabit, respectively, from 25 camels, 7 goats, and 4 sheep. One camel in Mandera and one goat in Wajir were confirmed positive for PPR virus (PPRV) through reverse Polymerase Cha

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Balamurugan, Vinayagamurthy, Bibitha Varghese, Kirubakaran Vinod Kumar, et al. "Seroprevalence study of peste des petits ruminants in sheep and goats in the northern region of India." August-2020 13, no. 8 (2020): 1573–80. http://dx.doi.org/10.14202/vetworld.2020.1573-1580.

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Background and Aim: Peste des petits ruminants (PPR) is a contagious, World Organization for Animal Health notifiable, economically important, transboundary morbilliviral disease of sheep and goats. Studying seroprevalence of PPR from different geographical areas under varying agro-climatic conditions may help in formulating effective and appropriate disease control strategies under the ongoing national PPR control program. The present cross-sectional study describes the prevalence of PPR virus antibodies in sheep and goats in the various epidemiological units in different states (Haryana, Him

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NIEDBALSKI, WIESŁAW. "Eradication of peste des petits ruminants: Application of new research to guide and facilitate the global elimination of the disease." Medycyna Weterynaryjna 76, no. 03 (2020): 6380–2020. http://dx.doi.org/10.21521/mw.6380.

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Peste des petits ruminants (PPR) is a highly contagious viral disease of domestic and wild small ruminants caused by the peste des petits ruminants virus (PPRV), which belongs to the genus Morbilivirus in the family Paramyxoviridae. The PPRV causes disease in goats and sheep, as well as in wild ruminants, such as gazelle, deer, antelope, Nubian ibex, gemsbok and others. PPR was first recorded in early 1942 in Ivory Coast, West Africa, and spread to around 70 countries in Africa, the Middle East and Asia – regions that are home to over 80% of the world’s sheep and goats. Until 2018, PPR had nev

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Woma, Timothy Yusufu, Demo Joab Usman Kalla, Pius Stephen Ekong, et al. "Serological evidence of camel exposure to peste des petits ruminants virus (PPRV) in Nigeria." Tropical Animal Health and Production 47, no. 3 (2014): 603–6. http://dx.doi.org/10.1007/s11250-014-0747-6.

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Ratta, Barkha, Mayank Pokhriyal, Shanker K. Singh, Ajay Kumar, Meeta Saxena, and Bhaskar Sharma. "Detection of Peste Des Petits Ruminants Virus (PPRV) Genome from Nasal Swabs of Dogs." Current Microbiology 73, no. 1 (2016): 99–103. http://dx.doi.org/10.1007/s00284-016-1030-z.

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Chaman, Sadia, Farrakh Zia Khan, Rabia Khokhar, et al. "Cytotoxic and antiviral potentials of Euphorbia milii var. splendens leaf against Peste des petits ruminant virus." Tropical Journal of Pharmaceutical Research 18, no. 7 (2021): 1507–11. http://dx.doi.org/10.4314/tjpr.v18i7.21.

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Purpose: To determine the cytotoxic and antiviral potentials of Euphorbia milii var. splendens leaf against Peste des petits ruminants virus (PPRV). Methods: The methanol extract, as well as n- hexane, chloroform, ethyl acetate, and n- butanol fractions of E. milii leaves were screened for cytotoxic and antiviral activities against PPRV using Vero cell line and 3-(4,5-dimethylthiazol-2-yl)-2,diphenyltetrazolium bromide (MTT) assay. Results: Non-cytotoxic concentrations with cell survival rate (CSP) greater than 50 % were considered virucidal. Methanol extract and fractions produced

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Yousuf, Md Abu, Md Mostafizur Rahman, Md Alauddin, et al. "Sero-surveillance of peste des petits ruminant viral antibody in goats at different areas of Bangladesh." Asian Journal of Medical and Biological Research 3, no. 3 (2017): 347–51. http://dx.doi.org/10.3329/ajmbr.v3i3.34524.

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Peste des petits ruminants (PPR) is a devastating and killer disease of domesticated small ruminants particularly goats. The present study was conducted on the serosurveillance of PPR in goats in different areas of Bangladesh. Blood samples were collected apparently from different years of age of goats in different areas of Bangladesh. All sera were subjected to serological test by competitive ELISA. For sero-surveillance of PPR virus total 200 serum samples were collected at different areas of Bangladesh such as Bogra18/60 (30%), Sirajganj 26/30 (86.67%), Mymensingh 5/50 (10%) and Rangpur 7/6

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Jones, Bryony Anne, Mana Mahapatra, Chobi Chubwa, et al. "Characterisation of Peste Des Petits Ruminants Disease in Pastoralist Flocks in Ngorongoro District of Northern Tanzania and Bluetongue Virus Co-Infection." Viruses 12, no. 4 (2020): 389. http://dx.doi.org/10.3390/v12040389.

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Peste des petits ruminants (PPR) disease was first confirmed in Tanzania in 2008 in sheep and goats in Ngorongoro District, northern Tanzania, and is now endemic in this area. This study aimed to characterise PPR disease in pastoralist small ruminant flocks in Ngorongoro District. During June 2015, 33 PPR-like disease reports were investigated in different parts of the district, using semi-structured interviews, clinical examinations, PPR virus rapid detection test (PPRV-RDT), and laboratory analysis. Ten flocks were confirmed as PPRV infected by PPRV-RDT and/or real-time reverse transcription

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Bataille, Arnaud, Habib Salami, Ismaila Seck, et al. "Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa." PLOS Pathogens 17, no. 3 (2021): e1009397. http://dx.doi.org/10.1371/journal.ppat.1009397.

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Peste des petits ruminants (PPR) is a deadly viral disease that mainly affects small domestic ruminants. This disease threaten global food security and rural economy but its control is complicated notably because of extensive, poorly monitored animal movements in infected regions. Here we combined the largest PPR virus genetic and animal mobility network data ever collected in a single region to improve our understanding of PPR endemic transmission dynamics in West African countries. Phylogenetic analyses identified the presence of multiple PPRV genetic clades that may be considered as part of

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