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Dissertations / Theses on the topic 'PET quantification'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Chonde, Daniel B. "Improved PET Data Quantification in Simultaneous PET/MR Neuroimaging." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467219.

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Recently, systems that integrate positron emission tomography and magnetic resonance imaging (PET/MR) have become available for clinical use. This new technology, which combines the high spatial resolution and superior soft-tissue contrast of MR with the picomolar sensitivity, quantitative capabilities, and wide array of tracers of PET, has the potential to benefit patients and provide insights that were previously unattainable in standalone systems. Simultaneous measurement of PET and MR parameters provides complementary information, allowing for a more complete assessment of disease, as wel

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2

Evans, Eleanor. "Improved quantification in small animal PET/MR." Thesis, University of Cambridge, 2015. https://www.repository.cam.ac.uk/handle/1810/252640.

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In translational medicine, complementary functional and morphological imaging techniques are used extensively to observe physiological processes in vivo and to assess structural changes as a result of disease progression. The combination of magnetic resonance imaging (MRI) and positron emission tomography (PET) provides excellent soft tissue contrast from MRI with exceptional sensitivity and specificity from PET. This thesis explores the use of sequentially acquired PET and MR images to improve the quantification of small animal PET data. The primary focus was to improve image-based estimates

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Herrick, Peter David Edmund. "Quantification challenges in simultaneous PET and MR." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608274.

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4

Lundquist, Pinelopi. "Imaging and Quantification of Brain Serotonergic Activity using PET." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6830.

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5

Thomas, B. A. "Improved brain PET quantification using partial volume correction techniques." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1352729/.

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Positron emission tomography (PET) suffers from a degradation in quantitative accuracy due to a phenomenon known as the partial volume effect (PVE). The effects are due to the limited spatial resolution of the scanner. Methods that correct for PVEs are known as partial volume correction (PVC) techniques and are either data-driven or make use of anatomical information from other modalities such as magnetic resonance (MR) imaging. This thesis reports investigations into PVC techniques for improving the quantification of brain amyloid PET tracers. These tracers image amyloid plaque aggregation in

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6

RAPISARDA, EUGENIO. "Improvements in quality and quantification of 3D PET images." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2012. http://hdl.handle.net/10281/28157.

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The spatial resolution of Positron Emission Tomography is conditioned by several physical factors, which can be taken into account by using a global Point Spread Function (PSF). In this thesis a spatially variant (radially asymmetric) PSF implementation in the image space of a 3D Ordered Subsets Expectation Maximization (OSEM) algorithm is proposed. Two different scanners were considered, without and with Time Of Flight (TOF) capability. The PSF was derived by fitting some experimentally acquired images of a Na22 cylindrical source reconstructed with an OSEM algorithm. The fitting function

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7

Kotze, C. W. "In vivo quantification of metabolic activity in aortic aneurysms using PET." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1463147/.

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Objective: To investigate the role of hybrid 18F-FDG PET/CT as a potential risk-stratification tool of aneurysm expansion by measuring metabolic activity on PET and textural analysis on CT in abdominal aortic aneurysm (AAA). Histological markers of AAA wall inflammatory cell infiltrate and enzymatic degradation have been associated with increased 18F-Fluorodeoxyglucose (18F-FDG)-Positron Emission Tomography /Computed Tomography (PET/CT) uptake. Methods: Fifty patients with asymptomatic infrarenal AAA enrolled under surveillance at one of our institutions underwent 18F-FDG-PET/CT. Seventeen sub

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Lilja, Johan. "[18F]Flutemetamol PET image processing, visualization and quantification targeting clinical routine." Doctoral thesis, Uppsala universitet, Radiologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-317688.

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Alzheimer’s disease (AD) is the leading cause of dementia and is alone responsible for 60-70% of all cases of dementia. Though sharing clinical symptoms with other types of dementia, the hallmarks of AD are the abundance of extracellular depositions of β-amyloid (Aβ) plaques, intracellular neurofibrillary tangles of hyper phosphorylated tau proteins and synaptic depletion. The onset of the physiological hallmarks may precede clinical symptoms with a decade or more, and once clinical symptoms occur it may be difficult to separate AD from other types of dementia based on clinical symptoms alone.

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GALLIVANONE, FRANCESCA. "Quantification methods for PET/CT oncological studies and correlation approacches with proteomic and hystological data." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/19696.

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Aim of the PhD work was the development and validation of methods for the extraction of quantitative biomarkers from in vivo molecular imaging (from PET/CT oncological studies) to be correlated with ex vivo molecular imaging indexes (from hystological and proteomic data).

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10

Bhatt, Ruchir N. "Positron Emission Tomography (PET) Tumor Segmentation and Quantification: Development of New Algorithms." FIU Digital Commons, 2012. http://digitalcommons.fiu.edu/etd/798.

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Tumor functional volume (FV) and its mean activity concentration (mAC) are the quantities derived from positron emission tomography (PET). These quantities are used for estimating radiation dose for a therapy, evaluating the progression of a disease and also use it as a prognostic indicator for predicting outcome. PET images have low resolution, high noise and affected by partial volume effect (PVE). Manually segmenting each tumor is very cumbersome and very hard to reproduce. To solve the above problem I developed an algorithm, called iterative deconvolution thresholding segmentation (IDTS) a

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11

Katiyar, Prateek [Verfasser]. "Quantification of tumor heterogeneity using PET/MRI and machine learning / Prateek Katiyar." Tübingen : Universitätsbibliothek Tübingen, 2021. http://d-nb.info/1238594883/34.

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12

CHINCARINI, ANDREA. "From clinics to methods and back: a tale of amyloid-PET quantification." Doctoral thesis, Università degli studi di Genova, 2018. http://hdl.handle.net/11567/929831.

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The in-vivo assessment of cerebral amyloid load is taking a leading role in the early differential diagnosis of neurodegenerative diseases. With the hopefully near introduction of disease-modifying drugs, we expect a paradigm shift in the current diagnostic pathway with an unprecedented surge in the request of exams and detailed analysis.

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13

Parodi, Katia. "On the feasibility of dose quantification with in-beam PET data in radiotherapy with 12C and proton beams." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-28788.

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This thesis has contributed to the achievement of in-beam PET as a promising clinical monitoring technique. In response to a pressing medical demand, this work has provided a tool for quantification of local dose deviations in case of observed discrepancies between the measured and expected PET images. The implemented interactive approach described in chapter 3 is in clinical use since 2001. It provides the radio-oncologist with a valuable feedback which may allow a prompt reaction in the strategy of the therapy prior to the delivery of the successive treatment fraction in case of signi

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Parodi, Katia. "On the feasibility of dose quantification with in-beam PET data in radiotherapy with 12C and proton beams." Rossendorf : Forschungszentrum, 2004. http://www.fz-rossendorf.de/publications/006865/6865.pdf.

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15

Salinas, Cristian Andres. "ROBUST EXPERIMENTAL DESIGN FOR ESTIMATING MYOCARDIAL BETA ADRENERGIC RECEPTOR CONCENTRATION USING POSITRON EMISSION TOMOGRAPHY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=case1144088920.

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Chakraborty, Chandrani. "Quantification of respiratory motion in PET/CT and its significance in radiation therapy." Oklahoma City : [s.n.], 2008.

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17

Chemli, Yanis. "Methods for improved brain PET quantification using super-resolution and non-negative matrix factorization." Electronic Thesis or Diss., Institut polytechnique de Paris, 2023. http://www.theses.fr/2023IPPAT026.

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L'avènement de radiotraceurs se liant aux repliements de protéines telles que l'amyloïde et les enchevêtrements neurofibrillaires (tau) a inauguré une nouvelle ère d'imagerie en tomographie par émission de positrons (TEP) pour les maladies neurodégénératives, apportant de nouvelles exigences pour la quantification et le traitement des images. En particulier, l'imagerie de la pathologie tau, surtout dans les premiers stades de la maladie, alimente un besoin d'amélioration de la quantification TEP pour permettre une imagerie précise de la distribution des traceurs plus focalisés et des petites s

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Fang, Yu-Hua. "Quantification of Pharmacokinetics in Small Animals with Molecular Imaging and Compartment Modeling Analysis." Cleveland, Ohio : Case Western Reserve University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1238635584.

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Thesis (Ph.D.)--Case Western Reserve University, 2009<br>Department of Biomedical Engineering Abstract Title from OhioLINK abstract screen (viewed on 10 April 2009) Available online via the OhioLINK ETD Center

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Vallot, Delphine. "Reconstruction adaptative optimisée pour la quantification en tomographie de positons couplée à un tomodensitomètre." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30188.

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L'étude a été initiée à l'occasion de la disponibilité d'un algorithme itératif de reconstruction en tomographie par émission de positons, qui présente l'avantage d'atteindre la convergence grâce à une méthode de régularisation. Il a donc fallu évaluer ses performances et son éventuel apport en comparaison aux algorithmes de référence, puis étudier l'influence du seul paramètre accessible aux utilisateurs pour une optimisation en clinique. Pour cela, plusieurs tests ont été réalisés, sur fantômes d'abord, puis sur patients car les résultats obtenus n'étaient pas directement transposables en cl

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Orlhac, Fanny. "Au-delà de la mesure de SUV en imagerie TEP : propriétés et potentiel des paramètres de texture pour caractériser les tumeurs." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA112198/document.

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Caractériser précisément l’hétérogénéité tumorale constitue un enjeu majeur en cancérologie. Le calcul de biomarqueurs de cette hétérogénéité directement à partir des données d’imagerie présente de nombreux avantages : il est non-invasif, répétable plusieurs fois au cours du traitement, ne nécessite pas d’examen supplémentaire et permet de caractériser la tumeur toute entière et ses éventuelles métastases. Mon projet de recherche visait à développer et évaluer des méthodes pour une caractérisation plus complète de l’activité métabolique des tumeurs. L’analyse de texture des images TEP nécessit

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Eckardt, Jörg. "Effects of patient motion on absolute quantification of glucose metabolism in cardiac positron emission tomography (PET)." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969106203.

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22

Kesner, Adam Leon. "Improving quantification and detection in PET imaging methods for image generation, analysis, and consequential clinical considerations /." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1680033171&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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23

Constable, Christopher. "Investigation of the Effects of Image Signal-to-Noise Ratio on TSPO PET Quantification of Neuroinflammation." Thesis, The University of Sydney, 2013. http://hdl.handle.net/2123/9341.

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Neuroinflammation may be imaged using positron emission tomography (PET) and the tracer [11C]-PK11195. Accurate and precise quantification of 18 kilodalton Translocator Protein (TSPO) binding parameters in the brain has proven difficult with this tracer, due to an unfavourable combination of low target concentration in tissue, low brain uptake of the tracer and relatively high non-specific binding, all of which leads to higher levels of relative image noise. To address these limitations, research into new radioligands for the TSPO, with higher brain uptake and lower non-specific binding relati

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Holman, B. "Improving quantification of PET/CT biomarkers for evaluation of disease progression and treatment effectiveness in pulmonary fibrosis." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1517678/.

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Idiopathic pulmonary fibrosis (IPF) is a progressive disease of unknown aetiology and with a high mortality rate. Treatment options are currently limited and the mean survival following diagnosis is 3 yrs. Recently, dynamic and static PET/CT has been used to image the IPF lung with the aim of improving the understanding of the disease mechanisms, monitoring disease progression and evaluating treatment effectiveness. Quantitative imaging of PET tracer uptake in the lung tissue of patients with any diffuse pulmonary disease is highly challenging due to the effects of breathing and the large pulm

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Boughdad, Sarah. "Contributions of radiomics in ¹⁸F-FDG PET/CT and in MRI in breast cancer." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS500.

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Le cancer du sein est une pathologie fréquente pour lequel les examens TEP/TDM au ¹⁸F-FDG et IRM mammaire sont fréquemment réalisés en routine. Il existe cependant une sous-utilisation des informations apportées par chacune de ces techniques d'imagerie. En pratique, l’interprétation de ces examens est principalement basée sur l’analyse visuelle et l'analyse « quantitative » se résume généralement au SUVmax seul en TEP/TDM et à l’étude du rehaussement du signal après injection de produit de contraste en IRM mammaire (DCE-MRI). L’arrivée de nouvelles machines hybrides TEP/ IRM, nous a amené à év

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Florea, Ioana. "Pet parametric imaging of acetylcholine esterase activity without arterial blood sampling in normal subjects and patients with neurovegetative disease." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425120.

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The development of a method for a reliable quantification of 11C-MP4A PET images without arterial input function at pixel level in order to study acetylcholine esterase activity (AChE) is of clinical interest for the diagnosis of dementia and memory disorders. Two groups of subjects, normal control group (4 subjects - NC group) and Alzheimer disease group (7 subjects - AD group) participated for the study. AChE activity can be quantify by using a reference input function derived from region having a very high metabolism by AChE and a three-rate constant compartmental model. In order to obtai

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Millardet, Maël. "Amélioration de la quantification des images TEP à l'yttrium 90." Thesis, Ecole centrale de Nantes, 2022. https://tel.archives-ouvertes.fr/tel-03871632.

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La popularité de l'imagerie TEP à l'yttrium 90 va grandissante. Cependant, la probabilité qu'une désintégration d'un noyau d'yttrium 90 mène à l'émission d'un positon n'est que de 3,2 × 10-5, et les images reconstruites sont par conséquent caractérisées par un niveau de bruit élevé, ainsi que par un biais positif dans les régions de faible activité. Pour corriger ces problèmes, les méthodes classiques consistent à utiliser des algorithmes pénalisés, ou autorisant des valeurs négatives dans l'image. Cependant, une étude comparant et combinant ces différentes méthodes dans le contexte spécifique

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Person, Christophe. "Quantification des anomalies neurologiques métaboliques et imagerie de sources électriques." Phd thesis, Université de Lorraine, 2012. http://tel.archives-ouvertes.fr/tel-00738247.

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Un traitement possible de l'épilepsie partielle pharmaco-résistante consiste en l'exérèse de la région cérébrale responsable des crises. La difficulté est de localiser cette zone et d'en définir l'étendue. L'objectif de cette thèse est d'apporter des données permettant de préciser la localisation et le volume des régions pathologiques, en exploitant deux modalités : l'imagerie TEP (Tomographie par Emission de Positons) et l'EEGHR (EEG Haute Résolution : signaux cérébraux recueillis sur le scalp avec un nombre important d'électrodes et une fréquence d'échantillonnage élevée). En imagerie TEP, i

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Sanchez, Crespo Alejandro. "Novel computational methods for image analysis and quantification using position sensitive radiation detectors." Doctoral thesis, Stockholm University, Medical Radiation Physics (together with KI), 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-754.

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<p>The major advantage of position sensitive radiation detector systems lies in their ability to non invasively map the regional distribution of the emitted radiation in real-time. Three of such detector systems were studied in this thesis, gamma-cameras, positron cameras and CMOS image sensors. A number of physical factors associated to these detectors degrade the qualitative and quantitative properties of the obtained images. These blurring factors could be divided into two groups. The first group consists of the general degrading factors inherent to the physical interaction processes of rad

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Geworski, Lilli. "Voraussetzungen für die Quantifizierung in der Emissions-Tomographie." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2004. http://dx.doi.org/10.18452/13918.

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Die Quantifizierung bei nuklearmedizinischen Untersuchungen bedeutet die Ermittlung der Aktivitätskonzentration im Gewebe und gegebenenfalls in einem weiteren Schritt die Bestimmung parametrischer Größen zur physiologischen Quantifizierung. Unter der Voraussetzung der korrekten Funktion des Gerätes (Qualitätskontrolle, Normalisierung, Kalibrierung) ist für die Quantifizierung die Anwendung folgender Korrekturen notwendig: Totzeit-, Absorptions-, Streustrahlungs- und ggf. Recovery-Korrektur wie auch Korrektur von zufälligen Koinzidenzen. Aus messtechnischer Sicht basiert die Überlegenheit der

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Zbib, Hiba. "Segmentation d'images TEP dynamiques par classification spectrale automatique et déterministe." Thesis, Tours, 2013. http://www.theses.fr/2013TOUR3317/document.

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La quantification d’images TEP dynamiques est un outil performant pour l’étude in vivo de la fonctionnalité des tissus. Cependant, cette quantification nécessite une définition des régions d’intérêts pour l’extraction des courbes temps-activité. Ces régions sont généralement identifiées manuellement par un opérateur expert, ce qui renforce leur subjectivité. En conséquent, un intérêt croissant a été porté sur le développement de méthodes de classification. Ces méthodes visent à séparer l’image TEP en des régions fonctionnelles en se basant sur les profils temporels des voxels. Dans cette thèse

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Palard, Xavier. "Quantification multiparamétrique par TEP à la 18F-Choline et IRM dans le cancer de la prostate." Thesis, Rennes 1, 2018. http://www.theses.fr/2018REN1B058.

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Problématique : Les paramètres fonctionnels extraits en Tomographie par Émission de Positons (TEP) à la 18F-Choline (FCH) et en Imagerie par Résonance Magnétique (IRM) apportent-ils une information supplémentaire par rapports aux informations déjà connues pour caractériser l’agressivité du tissu tumoral ? Objectifs : Notre travail avait pour objectifs tout d’abord (i) de mettre en évidence un éventuel lien entre les paramètres quantitatifs extraits par TEP à la FCH et et les paramètres clinicopathologiques dans le cancer de la prostate. Après cette étude préliminaire, pour quantifier au mieux

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Tomasi, Giampaolo. "Bayesian and population approaches for pixel-wise quantification of positron emission Tomography images: ridge regression and Global-Two-Stage." Doctoral thesis, Università degli studi di Padova, 2007. http://hdl.handle.net/11577/3425164.

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PET (Positron Emission Tomography) is a technique in which a radioactive tracer which decays by positron emission is injected into the subject's body. Through a complex instrumentation and sophisticated reconstruction algorithms, it is then possible to compute the distribution of the tracer over time in the area of interest, which is the desired outcome of the measurement. After reconstruction the image is ready for quantitative analysis, necessary to derive the so-called kinetic parameters, which are relevant in that they have a physiological meaning. This analysis may be performed either at

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Ziajahromi, Shima. "Identification and quantification of microplastics in wastewater treatment plant effluent: Investigation of the fate and biological effects." Thesis, Griffith University, 2018. http://hdl.handle.net/10072/378550.

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Microplastics (i.e., plastics particles < 5mm) are widespread emerging contaminants that have been detected in various aquatic environments worldwide including freshwater and marine ecosystems. Contamination of the environment with microplastics has become an environmental issue due to the potential of plastics to remain for thousands of years and to accumulate in the aquatic environment. The abundance of microplastics in the aquatic environment is assumed to increase due to continuous fragmentation of macro and microplastic debris, which can lead to a decrease in the average size ranges of mi

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Person, Christophe. "Quantification des anomalies neurologiques métaboliques et imagerie de sources électriques." Electronic Thesis or Diss., Université de Lorraine, 2012. http://www.theses.fr/2012LORR0214.

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Un traitement possible de l'épilepsie partielle pharmaco-résistante consiste en l'exérèse de la région cérébrale responsable des crises. La difficulté est de localiser cette zone et d'en définir l'étendue. L'objectif de cette thèse est d'apporter des données permettant de préciser la localisation et le volume des régions pathologiques, en exploitant deux modalités : l'imagerie TEP (Tomographie par Emission de Positons) et l'EEGHR (EEG Haute Résolution : signaux cérébraux recueillis sur le scalp avec un nombre important d'électrodes et une fréquence d'échantillonnage élevée). En imagerie TEP, i

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Verger, Antoine. "Quantification du métabolisme glycolytique cérébral en imagerie TEP au 18F-FDG : caractérisation de l’impact du vieillissement et de sa composante accélérée d’origine vasculaire." Thesis, Université de Lorraine, 2015. http://www.theses.fr/2015LORR0274/document.

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La tomographie par émission de positons au 18F-Fluorodésoxyglucose (TEP au 18F-FDG) est une technique d’imagerie permettant de quantifier le métabolisme glycolytique cérébral. L’objectif de nos travaux de thèse était d’essayer de caractériser au mieux les modifications cérébrales liées au vieillissement, y compris la partie possiblement liée à des dysfonctions vasculaires, grâce à une analyse quantitative tridimensionnelle voxel-à-voxel des images de TEP au 18F-FDG. Nos travaux montrent, tout d’abord, qu’il existe un intérêt pratique à utiliser un logiciel de normalisation spatial particulier

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Thuillier, Philippe. "Optimisation des paramètres de quantification en imagerie TEP pour le diagnostic, l'évaluation thérapeuthique et le pronostic des cancers endocriniens Malignancy rate of focal thyroid incidentaloma detected by FDG PET–CT: results of a prospective cohort study, in Endocrine Connections 6(6), 2017 Diagnostic Value of FDG PET-CT Quantitative Parameters and Deauville-Like 5 Point-Scale in Predicting Malignancy of Focal Thyroid Incidentaloma, in Frontiers in Medicine 6(24), February 2019." Thesis, Brest, 2019. http://www.theses.fr/2019BRES0088.

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L’objectif de ce travail de thèse était de proposer une approche systématique et raisonnée des outils de quantification disponibles en routine clinique et du domaine de la recherche dans la prise en charge des patients atteints d’une tumeur endocrine. Nos résultats font état des limites des paramètres semi-quantitatifs pour faire le diagnostic de malignité d’un ITf fixant au 18FDG-TEP/TDM. Nos données sur l’intérêt des paramètres de textures dans le diagnostic de malignité des tumeurs surrénaliennes nous montrent des performances excellentes de ces indices mais qui n’apparaissent cependant pas

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Soussan, Michaël. "Developpement et applications cliniques de methodes de quantification en TEP pour le pronostic et le suivi therapeutique des cancers." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA112135.

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A l’ère de la médecine personnalisée, de la génomique et des thérapies ciblées, les outils quantitatifs en imagerie médicale, et en particulier en imagerie fonctionnelle par Tomographie par Emission de Positons (TEP), apparaissent incontournables. Au-delà de la mesure de l’intensité de la fixation, il est possible de disposer d’index quantitatifs caractérisant l’ensemble du volume tumoral métabolique et d’en évaluer l’hétérogénéité. L’objectif de ce travail a été d’étudier la valeur de nouveaux indices quantitatifs en imagerie TEP, permettant une analyse plus globale de la tumeur. Une première

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Roman, Jimenez Geoffrey. "Analyse des images de tomographie par émission de positons pour la prédiction de récidive du cancer du col de l'utérus." Thesis, Rennes 1, 2016. http://www.theses.fr/2016REN1S037/document.

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Ces travaux de thèse s'inscrivent dans le contexte de la prédiction de la récidive en radiothérapie du cancer de l'utérus. L'objectif était d'analyser les images de tomographie par émission de positons (TEP) au 18F-fluorodésoxyglucose (18F-FDG) en vue d'en extraire des paramètres quantitatifs statistiquement corrélés aux événements de récidive. Six études ont été réalisées afin de répondre aux différentes problématiques soulevées par l'analyse des images 18F-FDG TEP telles que la présence d'artefact, l'isolation du métabolisme tumoral ou l'évaluation du signal en cours de traitement. Les étude

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Pacheco, Edward Flórez. "Quantificação da dinâmica de estruturas em imagens de medicina nuclear na modalidade PET." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/3/3142/tde-08052012-114807/.

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A presença que tem hoje a Medicina Nuclear como modalidade de obtenção de imagens médicas é muito importante e um dos principais procedimentos utilizados hoje nos centros de saúde, tendo como grande vantagem a capacidade de conseguir analisar o comportamento metabólico do paciente, fazendo possíveis diagnósticos precoces. Este projeto está baseado em imagens médicas obtidas através da modalidade PET (Positron Emission Tomography) a qual está tendo uma crescente difusão e aceitação. Para isso, temos desenvolvido uma estrutura integral de processamento de imagens tridimensionais PET, a qual está

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Kaiser, Lena [Verfasser], and Guido [Akademischer Betreuer] Böning. "Non-invasive quantification of CNS pathology with dynamic PET information: Investigation of advanced methods for the characterisation of multiple sclerosis and glioma lesions / Lena Kaiser ; Betreuer: Guido Böning." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1191691705/34.

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Kaltenbach, Tanja Eva-Maria [Verfasser]. "Vergleich von Kontrastmittelsonographie (SonoVue) und weiteren Ultraschallmodalitäten (B-Bild, Dopplersonografie, Acoustic Structure Quantification) mit F-18-FDG-PET-CT bei Patienten mit alveolärer Echinokokkose. / Tanja Eva-Maria Kaltenbach." Ulm : Universität Ulm. Medizinische Fakultät, 2015. http://d-nb.info/1066736340/34.

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Jaouen, Vincent. "Traitement des images multicomposantes par EDP : application à l'imagerie TEP dynamique." Thesis, Tours, 2016. http://www.theses.fr/2016TOUR3303/document.

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Cette thèse présente plusieurs contributions méthodologiques au traitement des images multicomposantes. Nous présentons notre travail dans le contexte applicatif difficile de l’imagerie de tomographie d’émission de positons dynamique (TEPd), une modalité d’imagerie fonctionnelle produisant des images multicomposantes fortement dégradées. Le caractère vectoriel du signal offre des propriétés de redondance et de complémentarité de l’information le long des différentes composantes permettant d’en améliorer le traitement. Notre première contribution exploite cet avantage pour la segmentation robus

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Rizzo, Gaia. "Development of novel computational algorithms for quantitative voxel-wise functional brain imaging with positron emission tomography." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422179.

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Positron Emission Tomography (PET) allows to study, in vivo, important biological processes in both animals and humans. In particular, it is widely used for receptor studies, where it allows quantitative functional imaging of physiological parameters in terms of receptor binding, volume of distribution, and/or receptor occupancy. In this thesis an overview on kinetic modeling in PET is presented, as well as some novel methodologies for voxel wise quantification of PET data, applied on various datasets. The proposed methods are a good alternative for the generation of reliable parametric maps

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Pacheco, Edward Florez. "Análise da dinâmica e quantificação metabólica de imagens de medicina nuclear na modalidade PET/CT." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/3/3142/tde-24062016-141858/.

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A presença da Medicina Nuclear como modalidade de obtenção de imagens médicas é um dos principais procedimentos utilizados hoje nos centros de saúde, tendo como grande vantagem a capacidade de analisar o comportamento metabólico do paciente, traduzindo-se em diagnósticos precoces. Entretanto, sabe-se que a quantificação em Medicina Nuclear é dificultada por diversos fatores, entre os quais estão a correção de atenuação, espalhamento, algoritmos de reconstrução e modelos assumidos. Neste contexto, o principal objetivo deste projeto foi melhorar a acurácia e a precisão na análise de imagens de P

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Veronese, Mattia. "A non compartmental method for functional quantitative imaging with Positron Emission Tomography and irreversible tracers." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3422660.

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In dynamic Positron Emission Tomography (PET) studies the term "Spectral Analysis" indicates a time-invariant single input/single output model, used for the data quantification [Cunningham and Jones, 1993]. Despite the name and its common use in the engineering field, SA does not indicate an analysis in the frequency domain but, instead, it represents a method from which the radioactivity concentration measured with PET can be related to the underlying physiological processes of the investigated system. SA is so-called, because it provides a “spectrum” of the kinetic components from which it i

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Maisonobe, Jacques-Antoine. "Caractérisation des tumeurs et de leur évolution en TEP/TDM au ¹⁸F-FDG pour le suivi thérapeutique." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00844243.

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La Tomographie par Emission de Positons (TEP) au Fluoro-déoxyglucose marqué au Fluor 18 (¹⁸F-FDG), analogue du glucose, permet d'obtenir une image de la consommation de glucose dans l'organisme. La plupart des foyers tumoraux présentant une consommation excessive de glucose, son utilisation en oncologie permet d'améliorer la prise en charge des patients en diminuant le temps nécessaire pour évaluer l'efficacité des traitements tels que la chimiothérapie et la radiothérapie. Mon projet de recherche visait à proposer et améliorer des méthodes de quantification en TEP au ¹⁸F-FDG afin de caractéri

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CAPRA, DAVIDE. "DETECTION AND QUANTIFICATION OF BREAST ARTERIAL CALCIFICATION AS A BIOMARKER OF CARDIOVASCULAR RISK IN WOMEN." Doctoral thesis, Università degli Studi di Milano, 2023. https://hdl.handle.net/2434/951303.

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Cardiovascular risk is underestimated in women: traditional risk scores do not consider sex-specific risk factors. As a matter of fact, cardiovascular disease (CVD) is the leading cause of mortality in the female population, and women are often undertreated and present worse cardiovascular outcomes than men. In a recently published call to action, the American Heart Association urges a cross-disciplinary approach to reduce the gender gap in cardiovascular health. In this context, breast arterial calcifications (BAC), an expression of Monckeberg’s sclerosis involving the tunica media of medium-

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Bernal, Moyano Jose. "Deep learning for atrophy quantification in brain magnetic resonance imaging." Doctoral thesis, Universitat de Girona, 2020. http://hdl.handle.net/10803/671699.

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The quantification of cerebral atrophy is fundamental in neuroinformatics since it permits diagnosing brain diseases, assessing their progression, and determining the effectiveness of novel treatments to counteract them. However, this is still an open and challenging problem since the performance 2/2 of traditional methods depends on imaging protocols and quality, data harmonisation errors, and brain abnormalities. In this doctoral thesis, we question whether deep learning methods can be used for better estimating cerebral atrophy from magnetic resonance images. Our work shows that deep lear

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Villbrand, Wilma. "Quantification of target per- and polyfluoroalkyl substances (PFASs) and extractable organic fluorine (EOF) in crayfish from Lake Vättern, Sweden." Thesis, Örebro universitet, Institutionen för naturvetenskap och teknik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-84879.

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Per- and polyfluorinated substances (PFASs) are a family of persistent organic pollutants in which the aliphatic carbon chains have been fluorinated, either completely or partially. One subclass of PFASs are perfluoroalkyl acids (PFAAs), in which perfluoroalkyl carboxylic acids (PFCAs) and perfluoroalkyl sulfonic acids (PFSAs) are two prominent groups. PFASs are toxic to the environment, as well as humans, and are found to have a developmental, neurological and immunological toxicity. They are also found to be possibly carcinogenic. In this study, the quantity of target PFASs was determined in

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