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Journal articles on the topic 'PFAS'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Park, Sunhwa, Deok-Hyun Kim, Jong-Hyun Yoon, et al. "Study on Pollution Characteristics of Perfluoroalkyl Substances (PFASs) in Shallow Groundwater." Water 15, no. 8 (2023): 1480. http://dx.doi.org/10.3390/w15081480.

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Perfluoroalkyl substances (PFASs) in shallow groundwater are increasingly being studied due to the global occurrence, environment persistence, bioaccumulation, and potential human health risk. In this research, 16 PFAS (11 perfluorinated carboxylic acids and 5 perfluorinated sulfonic acids) concentrations in groundwater were quantified to obtain information on geographical distribution and PFAS detection pattern for 4 years in South Korea. In the results, groundwater PFAS concentration ranged from non-detectable to average 45.2 ng/L (sum of PFASs). The major PFAS compounds were perfluorooctano

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Xiao, Christina, Philippe Grandjean, Damaskini Valvi, et al. "Associations of Exposure to Perfluoroalkyl Substances With Thyroid Hormone Concentrations and Birth Size." Journal of Clinical Endocrinology & Metabolism 105, no. 3 (2019): 735–45. http://dx.doi.org/10.1210/clinem/dgz147.

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Abstract Background Adequate thyroid function during pregnancy is essential for optimal fetal growth. Gestational exposure to perfluoroalkyl substances (PFAS) can negatively affect birth size and disrupt maternal and neonatal thyroid function, although the interrelationship is unclear. Objective We aimed to quantify the associations between maternal serum–PFAS concentrations and birth weight, birth length, and cranial circumference. We also aimed to estimate associations between PFAS and thyroid hormone (TH) concentrations, thereby elucidating whether THs potentially mediate the associations b

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Son, Heejong, Taehoon Kim, Hoon-Sik Yoom, Dongye Zhao, and Byungryul An. "The Adsorption Selectivity of Short and Long Per- and Polyfluoroalkyl Substances (PFASs) from Surface Water Using Powder-Activated Carbon." Water 12, no. 11 (2020): 3287. http://dx.doi.org/10.3390/w12113287.

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Nine per- and polyfluoroalkyl substances (PFASs), including six perfluoroalkyl carboxylic acids (PFCAs) and three perfluoroalkyl sulfonic acids (PFSAs), were tested to find their adsorption selectivity from surface water and the feasibility of the powder activated carbon (PAC) process between the perchlorination and coagulation processes by operating parameters such as mixing intensity, dosage, contact time, initial pH, and concentration of perchlorination. The removal efficiency of four types of PAC revealed that the coal-based activated carbon was clearly advanced for all of the PFASs, and t

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Junttila, Vähä, Perkola, et al. "PFASs in Finnish Rivers and Fish and the Loading of PFASs to the Baltic Sea." Water 11, no. 4 (2019): 870. http://dx.doi.org/10.3390/w11040870.

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The concentrations of per- and polyfluoroalkyl substances (PFASs) in the Finnish aquatic environment were measured in riverine waters and in inland, coastal and open sea fish. In addition, the PFAS load to the Baltic Sea from 11 rivers was calculated. Measurements show that PFASs, including restricted perfluorooctane sulfonic acid (PFOS), are widely present in the Finnish aquatic environment. At three out of 45 sampling sites, the concentration of PFOS in fish exceeded the environmental quality standard (EQS) of the Water Framework Directive (WFD). The annual average (AA) ∑23PFAS concentration

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Parashar, Neha, Byomkesh Mahanty, and Subrata Hait. "Microplastics as carriers of per- and polyfluoroalkyl substances (PFAS) in aquatic environment: interactions and ecotoxicological effects." Water Emerging Contaminants & Nanoplastics 3, no. 3 (2023): 15. http://dx.doi.org/10.20517/wecn.2023.25.

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MPs act as carriers of organic pollutants, including per- and polyfluoroalkyl substances (PFASs) in aquatic environments and exhibit harmful effects on organisms. Although there has been extensive research on the abundance and distribution MPs and PFASs individually, their co-occurrence and combined ecotoxicological effects have been poorly understood. In this context, the present review aims to present an up-to-date understanding of PFAS sorption onto MPs and their bioaccumulation in different organisms. The combined sources and prevalence of MPs and PFASs are summarized, with some daily-use

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Tamanna, Tasnuva, Peter J. Mahon, Rosalie K. Hockings, et al. "Ion Exchange MIEX® GOLD Resin as a Promising Sorbent for the Removal of PFAS Compounds." Applied Sciences 13, no. 10 (2023): 6263. http://dx.doi.org/10.3390/app13106263.

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Per- and polyfluoroalkyl substances (PFASs) are synthetic compounds, which have been widely produced, used, and recently identified as extremely toxic chemicals, and are responsible for serious environmental and human health risks. In this study, the removal efficiency of MIEX® GOLD resin was tested against six PFAS compounds including perfluorobutanoic acid (PFBA), perfluorobutanesulfonic acid (PFBS), perfluorohexanoic acid (PFHxA), perfluorohexanesulfonic acid (PFHxS), perfluorooctanoic acid (PFOA), and perfluorooctanesulfonic acid (PFOS). The removal of PFASs and the regeneration of resin (

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Abunada, Ziyad, Motasem Y. D. Alazaiza, and Mohammed J. K. Bashir. "An Overview of Per- and Polyfluoroalkyl Substances (PFAS) in the Environment: Source, Fate, Risk and Regulations." Water 12, no. 12 (2020): 3590. http://dx.doi.org/10.3390/w12123590.

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The current article reviews the state of art of the perfluoroalkyl and polyfluoroalkyl substances (PFASs) compounds and provides an overview of PFASs occurrence in the environment, wildlife, and humans. This study reviews the issues concerning PFASs exposure and potential risks generated with a focus on PFAS occurrence and transformation in various media, discusses their physicochemical characterization and treatment technologies, before discussing the potential human exposure routes. The various toxicological impacts to human health are also discussed. The article pays particular attention to

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Ali, Aasim M., Christopher P. Higgins, Walied M. Alarif, Sultan S. Al-Lihaibi, Mohammed Ghandourah, and Roland Kallenborn. "Per- and polyfluoroalkyl substances (PFASs) in contaminated coastal marine waters of the Saudi Arabian Red Sea: a baseline study." Environmental Science and Pollution Research 28, no. 3 (2020): 2791–803. http://dx.doi.org/10.1007/s11356-020-09897-5.

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AbstractPer- and polyfluoroalkyl substances (PFASs) are today considered important constituents of the continuously growing substance group of persistent contaminants of emerging environmental concern (PCEC). Here, we report for the first time the concentrations of 12 relevant PFASs in 28 marine water samples from the Saudi Arabian coastal waters of the Red Sea. The sum levels of 12 PFASs (Σ12 PFAS) in surface seawater ranged from <LOQ to 956 ngL−1. For the reference background site of this study, Σ12 PFAS levels ranged from <LOQ to 10.9 ng/L. The highest PFAS levels have been found in A

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Lee, Jocelyn C., Slim Smaoui, John Duffill, Ben Marandi, and Theodoros Varzakas. "Research Progress in Current and Emerging Issues of PFASs’ Global Impact: Long-Term Health Effects and Governance of Food Systems." Foods 14, no. 6 (2025): 958. https://doi.org/10.3390/foods14060958.

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Per- and polyfluoroalkyl substances (PFASs) are found everywhere, including food, cosmetics, and pharmaceuticals. This review introduces PFASs comprehensively, discussing their nature and identifying their interconnection with microplastics and their impacts on public health and the environment. The human cost of decades of delay, cover-ups, and mismanagement of PFASs and plastic waste is outlined and briefly explained. Following that, PFASs and long-term health effects are critically assessed. Risk assessment is then critically reviewed, mentioning different tools and models. Scientific resea

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Groffen, Thimo, Niels Kuijper, Sevgi Oden, Tim Willems, Lieven Bervoets, and Els Prinsen. "Growth Hormones in Broad Bean (Vicia faba L.) and Radish (Raphanus raphanistrum subsp. sativus L.) Are Associated with Accumulated Concentrations of Perfluoroalkyl Substances." Toxics 11, no. 11 (2023): 922. http://dx.doi.org/10.3390/toxics11110922.

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In this study, we grew radish (Raphanus raphanistrum subsp. sativus L.) and broad beans (Vicia faba L.) in a greenhouse on soils spiked with a mixture of 15 per- and polyfluoroalkyl substances (PFASs) and investigated the association between accumulated ∑PFAS concentrations, growth, and hormone levels. Short-chained PFASs dominated aboveground tissues, whereas long-chained PFASs were most abundant in the plant roots. Our results showed that the presence or absence of exodermal Casparian strips, as well as the hydrophobicity and anion exchange capacities of PFASs, could explain the translocatio

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Dartey, Emmanuel, Dag G. Ellingsen, Balazs Berlinger, et al. "Per- and Polyfluoroalkyl Substances in Human Serum Samples of Selected Populations from Ghana." International Journal of Environmental Research and Public Health 18, no. 4 (2021): 1581. http://dx.doi.org/10.3390/ijerph18041581.

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The aims of this study were to assess serum concentrations of per- and polyfluoroalkyl substances (PFASs) in selected populations from Ghana, including workers engaged in the repair of electronic equipment (ERWs), and to elucidate PFAS concentrations in relation to blood mercury concentrations (B-Hg) as a biomarker of seafood consumption. In all, 219 participants were recruited into the study, of which 26 were women and 64 were ERWs. Overall, the PFAS concentrations were low. The most abundant components were perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonic acid (PFHxS). Women had

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Draghi, Susanna, Giulio Curone, Radmila Pavlovic, et al. "Influence of Area, Age and Sex on Per- and Polyfluorinated Alkyl Substances Detected in Roe Deer Muscle and Liver from Selected Areas of Northern Italy." Animals 14, no. 4 (2024): 529. http://dx.doi.org/10.3390/ani14040529.

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Due to their physicochemical properties, per- and polyfluorinated alkyl substances (PFASs) persist and bioaccumulate in living organisms, causing adverse health effects. Since exposure to xenobiotics is influenced by factors related to both the living organism and the considered compounds, biomonitoring PFASs’ presence in the environment is of crucial importance. This study aimed to detect and quantify 15 PFASs in the muscle and liver of 40 roe deer from a specific area in Northern Italy by UPLC-HRMS. In the roe deer, liver PFAS concentrations were higher than those seen in muscle (p < 0.05

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Rodriguez, Kelsey L., Jae-Hoon Hwang, Amirsalar R. Esfahani, A. H. M. Anwar Sadmani, and Woo Hyoung Lee. "Recent Developments of PFAS-Detecting Sensors and Future Direction: A Review." Micromachines 11, no. 7 (2020): 667. http://dx.doi.org/10.3390/mi11070667.

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Per- and poly-fluoroalkyl substances (PFASs) have recently been labeled as toxic constituents that exist in many aqueous environments. However, traditional methods used to determine the level of PFASs are often not appropriate for continuous environmental monitoring and management. Based on the current state of research, PFAS-detecting sensors have surfaced as a promising method of determination. These sensors are an innovative solution with characteristics that allow for in situ, low-cost, and easy-to-use capabilities. This paper presents a comprehensive review of the recent developments in P

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Moretti, Simone, Silvia Castellini, Carolina Barola, et al. "Determination of Perfluorinated and Polyfluorinated Alkyl Substances (PFASs) in PM10 Samples: Analytical Method, Seasonal Trends, and Implications for Urban Air Quality in the City of Terni (Central Italy)." Separations 11, no. 2 (2024): 42. http://dx.doi.org/10.3390/separations11020042.

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A quantitative analytical method for PFAS determination in airborne particulate matter (PM) has been developed using liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS), allowing for the determination of 33 compounds. The procedure was applied to ambient PM10 with limits of quantification for PFAS in the fg m−3 range. PM10 samples collected during a year-long campaign conducted in an urban site in Umbria (Central Italy) have been characterized for their PFAS content. Among the seven detected PFASs, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) we

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Ferrario, Claudia, Cosimo Peruzzi, Alessio Cislaghi, et al. "Assessment of Reed Grasses (Phragmites australis) Performance in PFAS Removal from Water: A Phytoremediation Pilot Plant Study." Water 14, no. 6 (2022): 946. http://dx.doi.org/10.3390/w14060946.

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Per- and polyfluoroalkyl substances (PFASs) have multiple emission sources, from industrial to domestic, and their high persistence and mobility help them to spread in all the networks of watercourses. Diffuse pollution of these compounds can be potentially mitigated by the application of green infrastructures, which are a pillar of the EU Green Deal. In this context, a phytoremediation pilot plant was realised and supplied by a contaminated well-located in Lonigo (Veneto Region, Italy) where surface and groundwaters were significantly impacted by perfluoroalkyl acids (PFAAs) discharges from a

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Meegoda, Jay N., Bruno Bezerra de Souza, Melissa Monteiro Casarini, and Jitendra A. Kewalramani. "A Review of PFAS Destruction Technologies." International Journal of Environmental Research and Public Health 19, no. 24 (2022): 16397. http://dx.doi.org/10.3390/ijerph192416397.

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Per- and polyfluoroalkyl substances (PFASs) are a family of highly toxic emerging contaminants that have caught the attention of both the public and private sectors due to their adverse health impacts on society. The scientific community has been laboriously working on two fronts: (1) adapting already existing and effective technologies in destroying organic contaminants for PFAS remediation and (2) developing new technologies to remediate PFAS. A common characteristic in both areas is the separation/removal of PFASs from other contaminants or media, followed by destruction. The widely adopted

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Seo, Seonyeong, Yoona Park, Seungmin Na, Junghee Lee, Wonseok Lee, and Minhee Kim. "Global Performance, Trends, and Challenges for Assessment and Management of Per- and Polyfluoroalkyl Substances (PFASs): A Critical Review." Journal of Environmental Analysis, Health and Toxicology 27, no. 1 (2024): 1–13. http://dx.doi.org/10.36278/jeaht.27.1.1.

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Per- and polyfluoroalkyl substances (PFASs) are a large and complex group of thousands of synthetic chemicals with different properties such as strong acidity, high surface activity at very low concentrations, high chemical stability, and water and oil repellency. Many PFASs have been used in various industrial and consumer applications based on the desired functionality and production capability, and have consequently emerged as pervasive environmental contaminants of major concern. Recognition that several PFASs are transported globally, bioaccumulate, and exert multiple adverse effects on e

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Hutchinson, Samuel, Tarsha Rieck, and XiangLan Wu. "Advanced PFAS precursor digestion methods for biosolids." Environmental Chemistry 17, no. 8 (2020): 558. http://dx.doi.org/10.1071/en20008.

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Environmental contextThe majority of biosolids produced in Australia from wastewater treatment processes are applied to agricultural land for beneficial use. We have demonstrated, through improvements to the analytical method, that levels of PFAS in biosolids are significantly higher than historically understood. The land application of biosolids could result in sensitive environments being exposed to PFAS at levels higher than previously anticipated. AbstractThe current industry standard for per- and polyfluoroalkyl substances (PFAS) analysis is for the measurement of only 28 PFAS, even thoug

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Shelly, Colleen, Philippe Grandjean, Youssef Oulhote, et al. "Early Life Exposures to Perfluoroalkyl Substances in Relation to Adipokine Hormone Levels at Birth and During Childhood." Journal of Clinical Endocrinology & Metabolism 104, no. 11 (2019): 5338–48. http://dx.doi.org/10.1210/jc.2019-00385.

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Abstract Background Birth cohort studies have linked exposure to perfluoroalkyl substances (PFASs) with child anthropometry. Metabolic hormone dysregulation needs to be considered as a potential adverse outcome pathway. We examined the associations between PFAS exposures and concentrations of adipokine hormones from birth to adolescence. Methods We studied 80 mother-child pairs from a Faroese cohort born in 1997 to 2000. Five PFASs were measured in maternal pregnancy serum and in child serum at ages 5, 7, and 13 years. Leptin, adiponectin, and resistin were analyzed in cord serum and child ser

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Salihović, Samira, Alex M. Dickens, Ida Schoultz, et al. "Simultaneous determination of perfluoroalkyl substances and bile acids in human serum using ultra-high-performance liquid chromatography–tandem mass spectrometry." Analytical and Bioanalytical Chemistry 412, no. 10 (2019): 2251–59. http://dx.doi.org/10.1007/s00216-019-02263-6.

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AbstractThere is evidence of a positive association between per- and polyfluoroalkyl substances (PFASs) and cholesterol levels in human plasma, which may be due to common reabsorption of PFASs and bile acids (BAs) in the gut. Here we report development and validation of a method that allows simultaneous, quantitative determination of PFASs and BAs in plasma, using 150 μL or 20 μL of sample. The method involves protein precipitation using 96-well plates. The instrumental analysis was performed with ultra-performance liquid chromatography–tandem mass spectrometry (UHPLC-MS), using reverse-phase

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Pavlovic, Radmila, Susanna Draghi, Alberto Pellegrini, et al. "High-Resolution Mass Spectrometry Non-Targeted Detection of Per- and Polyfluoroalkyl Substances in Roe Deer (Capreolus capreolus)." Molecules 29, no. 3 (2024): 617. http://dx.doi.org/10.3390/molecules29030617.

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Among wildlife species, roe deer stands out as a valuable indicator of environmental pollution due to its ecological significance and role as a game animal. The assessment of poly- and perfluoro substances (PFASs) bioaccumulation is of the utmost importance, relying on the liver and muscles as the main organs of interest. The study concerned the identification of 60 PFAS through a non-target workflow analysis based on HPLC Q-Exactive Orbitrap High-Resolution Mass Spectrometry in a homogeneous group of 18 female roe deer species. The developed strategy allowed us to individuate the 60 PFAS comp

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Surma, Magdalena, Katarzyna Sznajder-Katarzyńska, Wiesław Wiczkowski, and Henryk Zieliński. "Assessment of Bioactive Surfactant Levels in Selected Cereal Products." Applied Sciences 12, no. 10 (2022): 5242. http://dx.doi.org/10.3390/app12105242.

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Per- and polyfluoroalkyl substances (PFASs) are bioactive surfactants that are widespread in the environment and living organisms. This study presents measurements of PFAS in selected food of plant origin that are part of the healthy eating pyramid, including bread, rolls, flour, bran, buckwheat, millet, rice, and noodles. A simple and reliable analytical method was developed for the simultaneous determination of seven perfluorocarboxylic acids (PFCAs) and three perfluoroalkane sulfonates (PFSAs) in cereal-based products. Out of the 10 PFASs, 5 PFASs were detected at levels above LOQ. The most

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Ma, Tingting, Xia Pan, Tiantian Wang, Xiuhua Li, and Yongming Luo. "Toxicity of Per- and Polyfluoroalkyl Substances to Nematodes." Toxics 11, no. 7 (2023): 593. http://dx.doi.org/10.3390/toxics11070593.

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Per- and polyfluoroalkyl substances (PFASs) are a class of compounds that persist in the environment globally. Besides being transported to the soil and sediments, which act as their sinks, PFASs can be transferred to several species of higher organisms directly or via bacteria, eliciting a wide range of adverse effects. Caenorhabditis elegans has been widely used in toxicological studies and life science research owing to its numerous advantages over traditional vertebrate models; notably, C. elegans has 65% conserved human-disease-associated genes and does not require ethical approvals for e

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Seo, Sung-Hee. "Health risk of Human Exposure to Perfluorinated Compounds (PFASs) in Hyeongsan River, Pohang." Journal of Environmental Analysis, Health and Toxicology 25, no. 3 (2022): 77–84. http://dx.doi.org/10.36278/jeaht.25.3.77.

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The aim of this study was to assess human health risks of exposure to perfluoroalkyl substances (PFASs) by ingestion of water from the Hyeongsan River in Pohang. Ingestion primarily acquired PFBS, PFNA, PFOS, and PFOA, but PFAAs rather than its precursors. Human exposure to PFASs was affected by the physicochemical properties of compounds, the emission sources, and the flow rate. The upstream and midstream waters were influenced by PFCAs due to the domestic sewage, whereas the downstream water contained high levels of PFBS and PFOS due to the presence of an industrial complex. Exposure levels

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Bezerra de Souza, Bruno, Jitendra A. Kewalramani, Richard W. Marsh, and Jay Meegoda. "Molecular Dynamics Simulation of the Impact of Functional Head Groups and Chain Lengths of PFAS Degradation Using Ultrasound Technology." Water 17, no. 7 (2025): 1025. https://doi.org/10.3390/w17071025.

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PFASs, or per- and polyfluoroalkyl substances, comprise a diverse group of synthetic chemicals known for their widespread use, persistence, and potential environmental and health risks. The sonolytic treatment of PFASs is one of the technologies with the ability to complete destruction without harmful byproducts. This study aims to provide a theoretical explanation for the sonolytic treatment of PFAS. Combining insights from molecular dynamics simulations with experimental data, the influence of chain length and functional headgroups on the PFAS destruction mechanism was investigated. The find

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Heinle, Brenna C., Tim N. Crawford, Sara J. Paton, and Naila Khalil. "Association of Perfluoroalkyl Substance with Lung Function in the US Population." Ohio Journal of Public Health 2, no. 2 (2019): 30–36. http://dx.doi.org/10.18061/ojph.v2i2.9032.

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Background/Aim: Perfluoroalkyl substances (PFASs) are chemical compounds used in consumer products and are linked with increases in cholesterol, thyroid disease, and pregnancy-induced hypertension. However, their association with lung function is not completely understood.Methods: Cross-sectional 2011-2012 US population data from the National Health and Nutrition Examination Survey (NHANES) were analyzed (n = 1450, aged 12 to 79 years, 50.5% females). Serum concentrations of 4 PFASs, perfluoronon-anoic acid (PFNA), perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perflu

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Gallagher, Andrea, Supratik Kar, and Maria S. Sepúlveda. "Computational Modeling of Human Serum Albumin Binding of Per- and Polyfluoroalkyl Substances Employing QSAR, Read-Across, and Docking." Molecules 28, no. 14 (2023): 5375. http://dx.doi.org/10.3390/molecules28145375.

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Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals in widespread use that have been shown to be toxic to wildlife and humans. Human serum albumin (HSA) is a known transport protein that binds PFAS at various sites, leading to bioaccumulation and long-term toxicity. In silico tools like quantitative structure-activity relationship (QSAR), read-across, and quantitative read-across structure-property relationship (q-RASPR) are proven techniques for modeling chemical toxicity based on experimental data which can be used to predict the toxicity of untested and new chemicals, while a

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Comfort, Steve, Amanda Araújo da Silva, Jessica Powell, Rebecca Cain, Ashleigh McGreer, and Renato F. Dantas. "Remediating Per- and Polyfluoroalkyl Substances (PFAS)-Contaminated Water by Foam Fractionation and Electrochemical Oxidation." Environments 12, no. 6 (2025): 185. https://doi.org/10.3390/environments12060185.

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Per- and polyfluoroalkyl substances (PFASs) are a family of synthetic chemicals that were used to improve the quality of several commercial products by making them resistant to heat, oil, stains, and grease. By containing a fluorinated carbon tail and a hydrophilic head (-COOH, -SO3H), PFASs act as surfactants that are attracted to bubble–water interfaces. Foam fractionation is the process of facilitating PFAS–air bubble interactions for the purpose of removing contaminants from tainted water. In this paper, we report on the use of foam fractionation and electrochemical oxidation (EO) under st

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Beccacece, Livia, Filippo Costa, Jennifer Paola Pascali, and Federico Manuel Giorgi. "Cross-Species Transcriptomics Analysis Highlights Conserved Molecular Responses to Per- and Polyfluoroalkyl Substances." Toxics 11, no. 7 (2023): 567. http://dx.doi.org/10.3390/toxics11070567.

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In recent decades, per- and polyfluoroalkyl substances (PFASs) have garnered widespread public attention due to their persistence in the environment and detrimental effects on the health of living organisms, spurring the generation of several transcriptome-centered investigations to understand the biological basis of their mechanism. In this study, we collected 2144 publicly available samples from seven distinct animal species to examine the molecular responses to PFAS exposure and to determine if there are conserved responses. Our comparative transcriptional analysis revealed that exposure to

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Brase, Richard A., Elizabeth J. Mullin, and David C. Spink. "Legacy and Emerging Per- and Polyfluoroalkyl Substances: Analytical Techniques, Environmental Fate, and Health Effects." International Journal of Molecular Sciences 22, no. 3 (2021): 995. http://dx.doi.org/10.3390/ijms22030995.

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Due to their unique chemical properties, per- and polyfluoroalkyl substances (PFAS) have been used extensively as industrial surfactants and processing aids. While several types of PFAS have been voluntarily phased out by their manufacturers, these chemicals continue to be of ecological and public health concern due to their persistence in the environment and their presence in living organisms. Moreover, while the compounds referred to as “legacy” PFAS remain in the environment, alternative compounds have emerged as replacements for their legacy predecessors and are now detected in numerous ma

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Abaie, Elham, Manish Kumar, Naveen Kumar та ін. "Application of β-Cyclodextrin Adsorbents in the Removal of Mixed Per- and PolyFluoroalkyl Substances". Toxics 12, № 4 (2024): 264. http://dx.doi.org/10.3390/toxics12040264.

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The extensive use of per- and polyfluoroalkyl substances (PFASs) in industrial consumer products has led to groundwater contamination, raising concerns for human health and the environment. These persistent chemicals exist in different forms with varying properties, which makes their removal challenging. In this study, we assessed the effectiveness of three different β-cyclodextrin (β-CD) adsorbents at removing a mixture of PFASs, including anionic, neutral, and zwitterionic compounds, at neutral pH. We calculated linear partition coefficient (Kd) values to quantify the adsorption affinity of

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Stanifer, John W., Heather M. Stapleton, Tomokazu Souma, Ashley Wittmer, Xinlu Zhao, and L. Ebony Boulware. "Perfluorinated Chemicals as Emerging Environmental Threats to Kidney Health." Clinical Journal of the American Society of Nephrology 13, no. 10 (2018): 1479–92. http://dx.doi.org/10.2215/cjn.04670418.

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Background and objectivesPer- and polyfluoroalkyl substances (PFASs) are a large group of manufactured nonbiodegradable compounds. Despite increasing awareness as global pollutants, the impact of PFAS exposure on human health is not well understood, and there are growing concerns for adverse effects on kidney function. Therefore, we conducted a scoping review to summarize and identify gaps in the understanding between PFAS exposure and kidney health.Design, setting, participants, & measurementsWe systematically searched PubMed, EMBASE, EBSCO Global Health, World Health Organization Global

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Voros, Charalampos, Diamantis Athanasiou, Ioannis Papapanagiotou, et al. "Molecular Shadows of Per- and Polyfluoroalkyl Substances (PFASs): Unveiling the Impact of Perfluoroalkyl Substances on Ovarian Function, Polycystic Ovarian Syndrome (PCOS), and In Vitro Fertilization (IVF) Outcomes." International Journal of Molecular Sciences 26, no. 14 (2025): 6604. https://doi.org/10.3390/ijms26146604.

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Per- and polyfluoroalkyl substances (PFASs) comprise a diverse array of synthetic chemicals that resist environmental degradation. They are increasingly recognised as endocrine-disrupting compounds (EDCs). These chemicals, found in non-stick cookware, food packaging, and industrial waste, accumulate in human tissues and fluids, raising substantial concerns regarding their impact on female reproductive health. Epidemiological studies have demonstrated associations between PFAS exposure and reduced fertility; nevertheless, the underlying molecular pathways remain inadequately understood. This na

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Seo, Seonyeong, and Minhee Kim. "Kinetics and Thermodynamics of Per - and Polyfluoroalkyl Substances (PFASs) Adsorption by Activated Carbon in Aqueous Systems." Journal of Environmental Analysis, Health and Toxicology 28, no. 1 (2025): 1–10. https://doi.org/10.36278/jeaht.28.1.1.

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Per- and polyfluoroalkyl substances (PFASs) are persistent environmental contaminants posing significant challenges in water treatment due to their stability and resistance to conventional removal methods. To enhance removal efficiency in treatment facilities, this study investigates the adsorption mechanisms of PFAS on activated carbon, focusing on the influence of the C-F chain length and functional groups through kinetic and thermodynamic analyses. The adsorption kinetics followed a pseudo-second order model, with adsorption rates increasing with longer C-F chains. This trend is likely driv

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Schlezinger, Jennifer J., and Noyan Gokce. "Perfluoroalkyl/Polyfluoroalkyl Substances: Links to Cardiovascular Disease Risk." Circulation Research 134, no. 9 (2024): 1136–59. http://dx.doi.org/10.1161/circresaha.124.323697.

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Conservative estimates by the World Health Organization suggest that at least a quarter of global cardiovascular diseases are attributable to environmental exposures. Associations between air pollution and cardiovascular risk have garnered the most headlines and are strong, but less attention has been paid to other omnipresent toxicants in our ecosystem. Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are man-made chemicals that are extensively used in industrial and consumer products worldwide and in aqueous film-forming foam utilized in firefighting. As such, our exposure to PFAS is es

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Hsu, Jen-Yi, Huei-Jie Jiang, Chih-Wei Chang, Yuan-Chih Chen, and Pao-Chi Liao. "High-Resolution Mass Spectrometry for Identification, Quantification, and Risk Assessment of 40 PFAS Migrating from Microwave Popcorn Bags." Molecules 30, no. 9 (2025): 1989. https://doi.org/10.3390/molecules30091989.

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Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are widely utilized in food contact materials (FCMs) due to their water- and oil-repellent properties, yet their potential migration into food raises significant health concerns. This study employs high-resolution mass spectrometry (HRMS) to quantify the migration of 40 PFAS from microwave popcorn bags and assess the associated health risks. HRMS offers high mass accuracy and resolution, enabling precise detection of a broad spectrum of PFASs, including those with low migration levels. Migration experiments were conducted using 10% ethanol

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Caban-Martinez, Alberto J., Paola Louzado Feliciano, Simi Oduwole, et al. "Abstract 25: Per- and polyfluoroalkyl substances and obesity in Florida firefighters." Cancer Research 82, no. 12_Supplement (2022): 25. http://dx.doi.org/10.1158/1538-7445.am2022-25.

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Abstract Background/Objective: Per- and polyfluoroalkyl substances (PFASs) are hazardous synthetic chemicals that have been linked to adverse human health effects such as cancer and endocrine disruption. Firefighters have been shown to be occupationally exposed to PFAS through aqueous film-forming foam (AFFF) used during difficult-to-suppress fires, and in the textile liners of their safety turnout gear. PFASs have both hydrophobic and hydrophilic chemical structures, giving them strong thermal stability and making them resistant to environmental and physiological degradation. Studies of human

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Yu, Ren-Shou, Hui-Ching Yu, Ying-Fei Yang, and Sher Singh. "A Global Overview of Per- and Polyfluoroalkyl Substance Regulatory Strategies and Their Environmental Impact." Toxics 13, no. 4 (2025): 251. https://doi.org/10.3390/toxics13040251.

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Per- and polyfluoroalkyl substances (PFASs), while possessing desirable properties for human society, have increasingly raised concerns due to their environmental persistence, bioaccumulation, and ecotoxicity. One of the major challenges with PFASs is the inconsistent adoption of regulatory strategies by authorities across different countries and regions, making it difficult to address the issue on a global scale. To obtain a global overview of PFAS regulatory patterns, this study utilized the most recent PFAS regulatory databases across different jurisdictions, both local and global. Among al

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Xu, Kairan, Jian Huang, Yufeng Zhang, et al. "Crop Contamination and Human Exposure to Per- and Polyfluoroalkyl Substances around a Fluorochemical Industrial Park in China." Toxics 12, no. 4 (2024): 269. http://dx.doi.org/10.3390/toxics12040269.

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Due to their significant environmental impact, there has been a gradual restriction of the production and utilization of legacy per- and polyfluoroalkyl substances (PFAS), leading to continuous development and adoption of novel alternatives. To effectively identify the potential environmental risks from crop consumption, the levels of 25 PFAS, including fourteen perfluoroalkyl acids (PFAAs), two precursor substances and nine novel alternatives, in agricultural soils and edible parts of various crops around a fluoride industrial park (FIP) in Changshu city, China, were measured. The concentrati

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Mottaleb, M. Abdul, Michael C. Petriello, and Andrew J. Morris. "High-Throughput UHPLC-MS/MS Measurement of Per- and Poly-Fluorinated Alkyl Substances in Human Serum." Journal of Analytical Toxicology 44, no. 4 (2020): 339–47. http://dx.doi.org/10.1093/jat/bkz097.

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Abstract Per- and poly-fluorinated alkyl substances (PFASs) are a large group of synthetic surfactant chemicals with widespread uses in food packaging and textile manufacturing and as the main constituent of aqueous film-forming firefighting foams. PFASs are highly persistent in the environment, and human exposures are extensive with these chemicals detectable in the blood of almost all adult Americans. PFASs exhibit a range of toxic effects in preclinical models. In humans, PFAS exposure has been associated with lower birth weights, decreased immune responses, cancer and impaired fertility an

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Draghi, Susanna, Radmila Pavlovic, Alberto Pellegrini, et al. "First Investigation of the Physiological Distribution of Legacy and Emerging Perfluoroalkyl Substances in Raw Bovine Milk According to the Component Fraction." Foods 12, no. 13 (2023): 2449. http://dx.doi.org/10.3390/foods12132449.

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Bovine milk is a pillar of the human diet and plays a key role in the nutrition of infants. Perfluoroalkyl substances (PFASs) are well-recognized highly stable organic compounds that are able to pollute ecosystems persistently and threaten both human and animal health. The study aimed to analyze the distribution of 14 PFASs within the milk matrix by comparing their content in whole milk, and its skimmed and creamed fractions. Raw milk samples were individually collected from 23 healthy cows (10 primiparous and 13 multiparous) reared on a farm in Northern Italy not surrounded by known point sou

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Sun, Miaomiao, and Yuqian Li. "Anthropogenic Release of Per- and Polyfluoroalkyl Substances into Surface Water Systems: Distribution Characteristics and Environmental Persistence Analysis." Water 17, no. 11 (2025): 1589. https://doi.org/10.3390/w17111589.

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In view of the issues including the incomplete identification of alternatives and difficulty in tracing pollution sources in PFAS pollution monitoring in surface water, this study took typical surface waters with intensive human activities as the object to perform PFAS screening. A nontarget analysis based on high-resolution mass spectrometry was developed, coupled with a modified solid phase extraction pretreatment method, to achieve the comprehensive screening of 12 legacy carboxylic acids and sulfonic acids, as well as 2 novel alternatives in water. Surface water samples were collected from

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Iannone, Alessia, Fabiana Carriera, Cristina Di Fiore, and Pasquale Avino. "Poly- and Perfluoroalkyl Substance (PFAS) Analysis in Environmental Matrices: An Overview of the Extraction and Chromatographic Detection Methods." Analytica 5, no. 2 (2024): 187–202. http://dx.doi.org/10.3390/analytica5020012.

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Per- and polyfluoroalkyl substances (PFASs) are carbon–fluorine compounds with widespread industrial and domestic use, posing potential toxicological risks to humans and ecosystems. Several analytical methods have been developed to assess the occurrence of PFASs in the environment, but a standardized method, applicable to all matrices, is still lacking. This paper reviews the extraction and chromatographic detection methods for PFAS assessment in environmental samples, considering parameters such as the LOD, LOQ, and recoveries. Solid phase extraction (SPE) is commonly used, showing high recov

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Sukhram, Shiryn D., Ji Kim, Sabrina Musovic, et al. "PFAS Exposure, Mental Health, and Environmental Justice in the United States: Impacts on Marginalized Communities." International Journal of Environmental Research and Public Health 22, no. 7 (2025): 1116. https://doi.org/10.3390/ijerph22071116.

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Per- and polyfluoroalkyl substances (PFASs), commonly known as “forever chemicals”, are synthetic compounds with highly stable carbon–fluorine bonds, making them resistant to environmental degradation. These chemicals accumulate in ecosystems and water supplies, posing significant risks to human health, including cancer, immune system dysfunction, and neurological disorders. However, the mental health impacts of PFAS exposure remain underexplored, particularly in marginalized communities. This review examines the emerging evidence linking PFAS exposure to mental health issues such as anxiety,

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Jaus, Alexandra, Peter Rhyn, and Judit Valentini. "Trace Level Analysis of Per- and Polyfluorinated Substances in Fish from Various Regions in Switzerland." Toxics 11, no. 11 (2023): 909. http://dx.doi.org/10.3390/toxics11110909.

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Per- and polyfluorinated substances (PFASs) are persistent man-made chemicals which can end up in the food chain. In this study, the concentrations of 15 PFASs in various wild fish species from different regions in Switzerland were determined excluding hot spots of contamination. After clean-up with SPE, the samples were analyzed by HPLC-MS/MS. PFASs were detected in all but 1 of the 83 fish samples (0.07 to 40.7 µg/kg fish muscle meat). The most abundant compound in fish from subalpine lakes was perfluorooctane sulfonic acid (PFOS), comprising more than 80% of the total contamination while pe

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Seo, Seonyeong, Junho Han, Seungmin Na, Junghee Lee, and Minhee Kim. "Influence of Molecular Structure on the Adsorption of Per - and Polyfluoroalkyl Substances (PFASs) to Activated Carbon in the Aqueous Phase." Journal of Environmental Analysis, Health and Toxicology 27, no. 4 (2024): 206–16. https://doi.org/10.36278/jeaht.27.4.206.

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Per- and polyfluoroalkyl substances (PFASs) exhibit extreme biological, chemical, and physical stability due to the strong carbon–fluorine bond. Because of their unique chemical and physical properties, PFASs are not efficiently removed in wastewater treatment plants, leading these facilities to serve as point sources for PFASs entering the environment. However, the mechanisms of PFAS removal in treatment systems remain poorly understood, largely due to their unique chemical characteristics and the diverse structures of compounds with varying chain lengths and functional groups. This study exa

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Olarewaju, Elizabeth, and Emmanuel Obeng-Gyasi. "Association of Per- and Polyfluoroalkyl Substances with Pan-Cancers Associated with Sex Hormones." Toxics 13, no. 6 (2025): 501. https://doi.org/10.3390/toxics13060501.

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Per- and polyfluoroalkyl substances (PFASs) are ubiquitous environmental contaminants with potential endocrine-disrupting properties. This study examines the association between exposure to multiple PFASs and pan-cancers associated with sex hormones (PCSH) while accounting for potential non-linear relationships and interactions. We analyzed data from the National Health and Nutrition Examination Survey (NHANES), spanning two-year cycles from 1999 to 2012 and including 14,373 participants. Serum concentrations of six PFAS—perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfl

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Trypidaki, Eirini, Silje Marie Bøe Gudmundsen, Georgios Karris, et al. "Occurrence of Novel and Legacy Per/Polyfluoroalkyl Substances (PFASs) in Scopoli’s Shearwater (Calonectris diomedea) Feathers." Diversity 16, no. 9 (2024): 541. http://dx.doi.org/10.3390/d16090541.

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Per- and polyfluoroalkyl substances (PFASs) are contaminants of great concern due to their ubiquitous environmental occurrence in the environment and their potential adverse effects on organisms. There is currently limited information regarding the occurrence of PFASs in Scopoli’s Shearwater (Calonectris diomedea). In this study, two feather samples per bird were obtained from 26 adults on Strofades colony (Ionian Sea/Greece) during the early phase of the chick-rearing period (late July 2019). The samples consisted of barbs and barbules of the primary feathers, P1 and P10, reflecting pollution

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Chen, Boting. "PFAS Characteristics and Treatment for Landfill Leachate." Highlights in Science, Engineering and Technology 33 (February 21, 2023): 24–28. http://dx.doi.org/10.54097/hset.v33i.5242.

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Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are manmade chemicals which has been extensively used, resulting in great potential for human and environmental accumulation due to high persistence. PFASs can be divided to two parts, terminal and precursor compounds, based on how many fluorine atoms link to the carbon bonds. Many studies have examined the removal ability of method including activated carbon (AC), Foam fractionation (FF), chemical oxidation and boron-doped diamond anodes (BBD). This paper focus on introducing advanced remedial technology for PFAS treatment from landfill le

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Navarro, Irene, la Torre Adrián De, Paloma Sanz, Javier Pro, Gregoria Carbonell, and María Ángeles Martínez. "Bioaccumulation of emerging organic compounds (perfluoroalkyl substances and halogenated flame retardants) by earthworm in biosolid amended soils." Environmental Research 149 (May 2, 2016): 32–39. https://doi.org/10.1016/j.envres.2016.05.004.

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In the present work, the bioaccumulation behavior of 49 target emerging organic compounds (20 perfluoroalkyl substances, PFASs, and 29 halogenated flame retardants, HFRs) was studied in soil invertebrates (Eisenia andrei). Multi species soil systems (MS 3) were used to assess the fate and the effects associated with the application of four biosolids in agricultural soil on terrestrial soil organisms. Biosolid amendment increased concentrations 1.5–14-fold for PFASs, 1.1–2.4-fold for polybrominated diphenyl ethers, PBDEs, and 1.1–3.6-fold for chlorinated flame retardants,

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