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1
Hyun, Jung O., Om P. Rajora, and Louis Zsuffa. "Inheritance and linkage of isozymes in Populus tremuloides (Michx.)." Genome 29, no. 2 (April 1, 1987): 384–88. http://dx.doi.org/10.1139/g87-066.
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Progenies of four controlled crosses were assayed electrophoretically to determine the inheritance of isozymes of 10 loci coding for six enzymes, aconitase (ACO), glutamate oxaloacetate transaminase (GOT), isocitrate dehydrogenase (IDH), phosphoglucomutase (PGM), 6-phosphogluconate dehydrogenase (6-PGD), and phosphoglucose isomerase (PGI), in roots of Populus tremuloides. Chi-square goodness of fit tests verified a single-gene Mendelian control of the segregating allozyme variants at each of five loci: Aco-1, Got, Pgm-2, 6-Pgd-2, and Pgi-2. Evidence was also obtained for a single-gene control of each of the remaining five loci (Aco-2, Idh, Pgm-1, 6-Pgd-1, and Pgi-1). ACO and PGM showed monomeric, while GOT, IDH, 6-PGD, and PGI had dimeric, banding patterns. The results of joint two-locus segregation tests indicated no linkage between 6-Pgd-2 and Pgi-2. Key words: Populus species, electrophoresis, allozymes, inheritance, linkage.
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Zhao, Qi, Ting-Yu Zhang, Yu-Jing Cheng, Yue Ma, Ying-Kai Xu, Jia-Qi Yang, and Yu-Jie Zhou. "Prognostic Significance of Relative Hyperglycemia after Percutaneous Coronary Intervention in Patients with and without Recognized Diabetes." Current Vascular Pharmacology 19, no. 1 (December 4, 2020): 91–101. http://dx.doi.org/10.2174/1570161118666200317145540.
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Background: The research on the association between the relative glycemic level postpercutaneous coronary intervention (PCI) and adverse prognosis in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients is relatively inadequate. Objective: The study aimed to identify whether the glycemic level post-PCI predicts adverse prognosis in NSTE-ACS patients. Methods: Patients (n=2465) admitted with NSTE-ACS who underwent PCI were enrolled. The relative glycemic level post-procedure was calculated as blood glucose level post-PCI divided by HbA1c level, which was named post-procedural glycemic index (PGI). The primary observational outcome of this study was major adverse cardiovascular events (MACE) [defined as a composite of all-cause death, non-fatal myocardial infarction (MI) and any revascularization]. Results: The association between PGI and MACE rate is presented as a U-shape curve. Higher PGIs [hazard ratio (HR): 1.669 (95% confidence interval (CI): 1.244-2.238) for the third quartile (Q3) and 2.076 (1.566-2.753) for the fourth quartile (Q4), p<0.001], adjusted for confounding factors, were considered to be one of the independent predictors of MACE. The association between the PGI and the risk of MACE was more prominent in the non-diabetic population [HR (95%CI) of 2.356 (1.456-3.812) for Q3 and 3.628 (2.265-5.812) for Q4, p<0.001]. There were no significant differences in MACE risk between PGI groups in the diabetic population. Conclusion: Higher PGI was a significant and independent predictor of MACE in NSTE-ACS patients treated with PCI. The prognostic effect of the PGI is more remarkable in subsets without pre-existing diabetes than in the overall population. The predictive value of PGI was not identified in the subgroup with diabetes.
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Vorsa, Nicholi, Paul S. Manos, and Maria I. van Heemstra. "Isozyme variation and inheritance in blueberry." Genome 30, no. 5 (October 1, 1988): 776–81. http://dx.doi.org/10.1139/g88-125.
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Leaf tissue extracts from diploid, tetraploid, and hexaploid species of blueberry, Vaccinium section Cyanococcus, were electrophoretically analyzed for isozyme polymorphism in 12 enzyme systems. Aldolase, shikimate dehydrogenase, triose phosphate isomerase, glucose-6-phosphate dehydrogenase, phosphoglucomutase, aconitase, alcohol dehydrogenase, and aspartate aminotransferase showed activity, but banding was not clear. Four enzymes, malate dehydrogenase (MDH), phosphoglucose isomerase (PGI), 6-phosphogluconate dehydrogenase (6-PGD), and isocitrate dehydrogenase (IDH), exhibited interpretable banding patterns. Two loci were apparent for MDH, PGI, and 6-PGD and one for IDH. Polymorphism was detected at Mdh-2, Pgi-2, 6-Pgd-2, and Idh. Three allozymes were found at Mdh-2 and Idh and at least four at Pgi-2 and 6-Pgd-2. Allozyme segregation ratios observed in progeny of controlled diploid crosses supported single-gene Mendelian inheritance. Banding patterns of all allozymes indicated a dimeric structure for these four enzymes. It appears that all alleles at multiallelic loci are expressed in polyploids. Preliminary data suggest that allozyme analyses may be useful in taxonomic studies in blueberry.Key words: Vaccinium, allozymes, inheritance, electrophoresis.
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Hulgan, Todd, M. Sean Boger, Diana H. Liao, Grace A. McComsey, Christine A. Wanke, Alexandra Mangili, Sharon L. Walmsley, et al. "Urinary Eicosanoid Metabolites in HIV-Infected Women with Central Obesity Switching to Raltegravir: An Analysis from the Women, Integrase, and Fat Accumulation Trial." Mediators of Inflammation 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/803095.
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Chronic inflammation is a hallmark of HIV infection. Eicosanoids reflect inflammation, oxidant stress, and vascular health and vary by sex and metabolic parameters. Raltegravir (RAL) is an HIV-1 integrase inhibitor that may have limited metabolic effects. We assessed urinary F2-isoprostanes (F2-IsoPs), prostaglandin E2(PGE-M), prostacyclin (PGI-M), and thromboxane B2(TxB2) in HIV-infected women switching to RAL-containing antiretroviral therapy (ART). Thirty-seven women (RAL = 17; PI/NNRTI = 20) with a median age of 43 years and BMI 32 kg/m2completed week 24. TxB2increased in the RAL versus PI/NNRTI arm (+0.09 versus −0.02;P=0.06). Baseline PGI-M was lower in the RAL arm (P=0.005); no other between-arm cross-sectional differences were observed. In the PI/NNRTI arm, 24-week visceral adipose tissue change correlated with PGI-M (rho=0.45;P=0.04) and TxB2(rho=0.44;P=0.005) changes, with a trend seen for PGE-M (rho=0.41;P=0.07). In an adjusted model, age ≥ 50 years (N=8) was associated with increased PGE-M(P=0.04). In this randomized trial, a switch to RAL did not significantly affect urinary eicosanoids over 24 weeks. In women continuing PI/NNRTI, increased visceral adipose tissue correlated with increased PGI-M and PGE-M. Older age (≥50) was associated with increased PGE-M. Relationships between aging, adiposity, ART, and eicosanoids during HIV-infection require further study.
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van Heemstra, M. I., L. P. Bruederle, and N. Vorsa. "Inheritance and Linkage of Thirteen Polymorphic Isozyme Loci in Diploid Blueberry." Journal of the American Society for Horticultural Science 116, no. 1 (January 1991): 89–94. http://dx.doi.org/10.21273/jashs.116.1.89.
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Diploid populations and progenies of controlled crosses of blueberry, Vaccinium section Cyanococcus, were analyzed by starch gel electrophoresis for nine enzyme systems, aconitase (ACO), aldolase (ALD), alcohol dehydrogenase (ADH), glyceraldehyde-3 -phosphate dehydrogenase (G-3-PDH), isocitrate dehydrogenase (IDH), leucine aminopeptidase (LAP), malate dehydrogenase (MDH), 6-phosphogluconate dehydrogenase (6-PGD), and phosphoglucose isomerase (PGI). Allozyme variants indicated the existence of three alleles at Ace-1, Ald, G-3-pdh-2, and Mdh-2; four alleles at Mdh-3 and 6-Pgd-2; five alleles at Aco-2, Idh, Lap-1, and 6-Pgd-1; six alleles at Adh-2 and Pgm-2; and nine alleles at Pgi-2. In addition, a null allele was found at Lap-1. In the majority of progenies, the inheritance patterns for each of these loci were consistent with mendelian laws for single gene control. Forty-seven pairs of loci were tested for independent assortment revealing two linked pairs, Pgi-2/Lap-1 and Pgm-2/6-Pgd-2, which appeared to represent two independent linkage groups.
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van Niekerk, B. D., Z. A. Pretorius, and W. H. P. Boshoff. "Pathogenic Variability of Puccinia coronata f. sp. avenae and P. graminis f. sp. avenae on Oat in South Africa." Plant Disease 85, no. 10 (October 2001): 1085–90. http://dx.doi.org/10.1094/pdis.2001.85.10.1085.
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Although crown rust (caused by Puccinia coronata f. sp. avenae) and stem rust (caused by Puccinia graminis f. sp. avenae) are generally considered to be the most widespread and damaging diseases of oat (Avena spp.) in South Africa, pathogenic variability has never been studied. During 1997 and 1998, one dominant crown rust pathotype (SBLL) was identified with virulence to resistance genes Pc40, Pc45, Pc46, Pc51, and Pc54. Four other pathotypes (SGLL, PBBB+Pc35, SDQL, and JBBM+Pc35), occurring at low frequencies and further rendering resistance genes Pc35, Pc39, Pc48, Pc50, Pc52, and Pc64 ineffective, were also detected. Resistance gene Pc40 was postulated in Wisconsin X1588-2; Pc51 in Euro, Maluti, Overberg, OX88I 075-106, Perdeberg, and Swartberg; and Pc39 was confirmed in the cultivar Fidler. During the same period, four stem rust pathotypes were identified with virulence to resistance genes Pg1, Pg2, Pg4, Pg8, Pg9, Pg12,Pg15, and Pga. Resistance gene Pga was postulated in Alpha, OX87 080-1, OX88I 075-106, Sederberg, and W94/4; Pg2 and/or Pg4 in Euro, Perdeberg, Potberg, and Swartberg; and Pg9 in Pallinup and Victorian. Collections of wild oat species Avena fatua, A. byzantina, A. sterilis, and A. barbata were susceptible to all crown rust patho-types, while the four stem rust pathotypes were virulent on all species except A. barbata.
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Howes, N. K., J. Chong, and P. D. Brown. "Oat endosperm proteins associated with resistance to stem rust of oats." Genome 35, no. 1 (February 1, 1992): 120–25. http://dx.doi.org/10.1139/g92-020.
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The presence of oat (Avena sativa L.) endosperm proteins, extracted with dimethylformamide mercaptoethanol – sodium dodecylsulfate and separated by dodecylsulfate polyacrylamide gel electrophoresis, was compared among cv. Rodney (carrying Pg4) and Rodney 0 derived backcross lines carrying single known genes Pg1, Pg2, Pg3, Pg8, Pg9, Pg13, Pg15, and Pg16, for stem rust resistance, and among other lines or cultivars with or without these genes. Most single-gene lines had polypeptide patterns similar to that of Rodney 0, a near-isogenic line with no known stem rust resistance. However, lines Rodney Pg3 and Rodney Pg9 were missing a 25.3-kDa avenin present in Rodney 0 and present in lines or cultivars that did not carry Pg9. The Rodney Pg13 line and several lines or cultivars that carried Pg13 were missing a 56.6-kDa polypeptide present in Rodney 0 and in several lines and cultivars that did not carry this gene. These results suggest that the Pg3/Pg9 and Pg13 loci were associated with the loci controlling the synthesis of the 25.3- and 56.6-kDa polypeptides, respectively. Results from genetic studies showed that gene Pg13 was linked in repulsion (linkage value 4.2 ± 1.9 cM) to the 56.6-kDa polypeptide locus.Key words: electrophoresis, oats, proteins, rust resistance.
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Beaver, J. A., and A. F. Iezzoni. "Allozyme Inheritance in Tetraploid Sour Cherry (Prunus cerasus L.)." Journal of the American Society for Horticultural Science 118, no. 6 (November 1993): 873–77. http://dx.doi.org/10.21273/jashs.118.6.873.
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Inheritance for seven enzyme loci was determined in seeds produced from crosses and self-pollinations involving four sour cherry parents and one open-pollinated ground cherry (P. fruticosa Pall.) parent. Segregation data were used to identify allozymes and determine whether sour cherry is a naturally occurring allo- or autotetraploid. Three allozymes were identified at the 6-Pgd-1 locus, and two were identified at each of the following loci: Pgi-2, Lap-1, Adh-1, Idh-2, Pgm-2, and 6-Pgd-2. Segregating allozyme patterns for the diagnostic loci Idh-2, Pgm-2, 6-Pgd-1, and 6-Pgd-2 tit disomic inheritance models and thus confirmed the allotetraploid hypothesis for sour cherry. Chi-square tests of independence between loci indicated that Pgi-2, Adh-1, Idh-2, 6-Pgd-1, and 6-Pgd-2 were not linked.
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Luo, J., X. Y. Cheng, X. Yan, W. Q. Tao, J. D. Holland, and R. M. Xu. "Characterization and polymorphism analysis of phosphoglucose isomerase gene in the fall webworm (Hyphantria cunea)." Bulletin of Entomological Research 102, no. 4 (February 7, 2012): 477–88. http://dx.doi.org/10.1017/s000748531100085x.
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AbstractPhosphoglucose isomerase (PGI) plays an important role in energy metabolism, and it is documented that PGI exhibits an extensive polymorphism which can affect insects' fitness and adaptation. In this paper, we studied the structural characteristics and polymorphism of pgi gene in the fall webworm (Hyphantria cunea), an important invasive pest in some European and Asian countries. A 2110-bp pgi full-length cDNA encoding a polypeptide of 556 amino acids was obtained from H. cunea. The pgi full-length in the H. cunea genomic DNA was 14,332 bp with 12 exons and 11 introns, similar to the structures of pgi in other Lepidoptera species. We compared the structures of pgi in different insect species. Moreover, thirteen pgi genotypes comprised of five alleles were identified in the Chinese population. Genotypes pgi-cd, pgi-cc and pgi-ce were the most prevalent with over 70% of individuals allocated to them. Four out of five alleles were sequenced the cDNA full-length. Thirty stably variable sites were found among them with five non-synonymous mutation sites. The frequencies of alleles and genotypes were variable in different Chinese geographic subpopulations. Moreover, comparison of pgi mRNA expression levels in each stage of the moth's lifecycle showed that a high expression level was in the 6th instar larval stage, followed by that in the egg and adult stages. The results will provide a basis for further study of the role of different alleles and genotypes of PGI on fitness and adaptation of the moth H. cunea.
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Kemp, G., L. Stanton, C. W. Bergmann, R. P. Clay, P. Albersheim, and A. Darvill. "Polygalacturonase-Inhibiting Proteins Can Function as Activators of Polygalacturonase." Molecular Plant-Microbe Interactions® 17, no. 8 (August 2004): 888–94. http://dx.doi.org/10.1094/mpmi.2004.17.8.888.
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The interaction between fungal endopolygalacturonases (EPGs) and polygalacturonase-inhibiting proteins (PGIPs) found in plant cell walls has been well established. The typical EPG/PGIP interaction is characterized by high affinity, reversibility, and a 1:1 stoichiometry that results in lowering the catalytic rate of a particular endopolygalacturonase by up to 99.7%. Various EPG and PGIP isoforms and glycoforms have been isolated and characterized, and combinations of EPGs and PGIPs demonstrate a range of enzyme inhibition. EPG/PGIP interactions have prompted many researchers to suspect the involvement of these proteins in the production of specific signals (oligosaccharins) during plant pathogenesis. We have recently reported on initial studies in our laboratory indicating that, for certain EPG/PGIP combinations, the specific activity of EPG is increased beyond that characteristic of the enzyme alone. In this paper, we rpesent a detailed analysis of the product of the interaction of native Phaseolus vulgaris PGIP-2 with five EPGs from Aspergillus niger, namely PGI, PGII, PGA, PGB, and PGC in the presence of homogalacturonan. We demonstrate that for PGA and PGC, the interaction with PGIP-2 may result in either inhibition or activation in a manner that is pH dependent. This data suggests the need for a reevaluation of the conventional description applied to PGIPs; suggestions include polygalacturonase-binding protein and polygalacturonase-modulating protein.
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Katz, Laura A., and Richard G. Harrison. "Balancing Selection on Electrophoretic Variation of Phosphoglucose Isomerase in Two Species of Field Cricket: Gryllus veletis and G. pennsylvanicus." Genetics 147, no. 2 (October 1, 1997): 609–21. http://dx.doi.org/10.1093/genetics/147.2.609.
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Two species of crickets, Gryllus veletis and G. pennsylvanicus, share six electrophoretic mobility classes for the enzyme phosphoglucose isomerase (PGI), despite evidence from other genetic markers that the two species are not closely related within eastern North American field crickets. Moreover, the frequencies of the two most common PGI electrophoretic classes (PGI-100 and PGI-65) covary in sympatric populations of these species in the eastern United States, suggesting that PGI may be subject to trans-specific balancing selection. To determine the molecular basis of the electrophoretic variation, we characterized the DNA sequence of the Pgi gene from 29 crickets (15 G. veletis and 14 G. pennsylvanicus). Amino acid substitutions that distinguish the electrophoretic classes are not the same in the two species, and there is no evidence that specific replacement substitutions represent trans-specific polymorphism. In particular, the amino acids that diagnose the PGI-65 allele relative to the PGI-100 allele differ both between G. veletis and G. pennsylvanicus and within G. pennsylvanicus. The heterogeneity among electrophoretic classes that covary in sympatric populations coupled with analysis of patterns of nucleotide variation suggest that Pgi is not evolving neutrally. Instead, the data are consistent with balancing selection operating on an emergent property of the PGI protein.
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Girelli, Chiara Roberta, Laura Del Coco, Samanta Zelasco, Amelia Salimonti, Francesca Luisa Conforti, Andrea Biagianti, Daniele Barbini, and Francesco Paolo Fanizzi. "Traceability of “Tuscan PGI” Extra Virgin Olive Oils by 1H NMR Metabolic Profiles Collection and Analysis." Metabolites 8, no. 4 (September 30, 2018): 60. http://dx.doi.org/10.3390/metabo8040060.
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According to Coldiretti, Italy still continues to hold the European Quality record in extra virgin olive oils with origin designation and protected geographical indication (PDO and PGI). To date, 46 Italian brands are recognized by the European Union: 42 PDO and 4 PGI (Tuscan PGI, Calabria PGI; Tuscia PGI and PGI Sicily). Specific regulations, introduced for these quality marks, include the designation of both the geographical areas and the plant varieties contributing to the composition of the olive oil. However, the PDO and PGI assessment procedures are currently based essentially on farmer declarations. Tuscan PGI extra virgin olive oil is one of the best known Italian trademarks around the world. Tuscan PGI varietal platform is rather wide including 31 specific olive cultivars which should account for at least 95% of the product. On the other hand, while the characteristics of other popular Italian extra virgin olive oils (EVOOs) cultivars from specific geographical areas have been extensively studied (such as those of Coratina based blends from Apulia), little is still known about Tuscan PGI EVOO constituents. In this work, we performed, for the first time, a large-scale analysis of Tuscan PGI monocultivar olive oils by 1H NMR spectroscopy and multivariate statistical analyses (MVA). After genetic characterization of 217 leaf samples from 24 selected geographical areas, distributed all over the Tuscany, a number of 202 micro-milled oil samples including 10 PGI cultivars, was studied. The results of the present work confirmed the need of monocultivar genetically certified EVOO samples for the construction of 1H-NMR-metabolic profiles databases suitable for cultivar and/or geographical origin assessment. Such specific PGI EVOOs databases could be profitably used to justify the high added value of the product and the sustainability of the related supply chain.
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Yin, Bingqing (Miranda), Yexin Jessica Li, and Surendra Singh. "Coins Are Cold and Cards Are Caring: The Effect of Pregiving Incentives on Charity Perceptions, Relationship Norms, and Donation Behavior." Journal of Marketing 84, no. 6 (June 25, 2020): 57–73. http://dx.doi.org/10.1177/0022242920931451.
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Charities often include low-value monetary (e.g., coins) and nonmonetary (e.g., greeting cards) pregiving incentives (PGIs) in their donation request letters. Yet little is known about how donors respond to this marketing strategy. In seven studies, including two large-scale field experiments, the authors demonstrate that the effectiveness of PGIs depends on the organization’s goals. People are more likely to open and read a letter containing a monetary PGI (vs. a nonmonetary PGI or no PGI). In addition, monetary PGIs increase response rates in donor acquisition campaigns. However, the return on investment for direct mail campaigns drops significantly when PGIs are included. Furthermore, average donations for appeals with a nonmonetary PGI or no PGI are similar, while those with a monetary PGI are actually lower than when a nonmonetary PGI or no PGI is included. This is because monetary PGIs increase exchange norms while decreasing communal norms. This effect remains significant when accounting for alternative explanations such as manipulative intent and the anchoring and adjustment heuristic.
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Liu, Huixing, Chunrong Fei, and Jun Zhang. "Associations of Serum Pepsinogens and Helicobacter Pylori Infection with High-Sensitivity C-Reactive Protein in Medical Examination Population." Laboratory Medicine 52, no. 1 (July 23, 2020): 57–63. http://dx.doi.org/10.1093/labmed/lmaa042.
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Abstract Objective This study aimed to clarify the distribution characteristics of serum pepsinogen (PG) and Helicobacter pylori in the medical examination population and to explore the relationships of PG level and H. pylori infection status with the high-sensitivity C-reactive protein (hsCRP) level and their significance in health examination. Methods We detected H. pylori infection by C13 urea breath test, the serum pepsinogen I (PGI) and pepsinogen II (PGII) contents were measured by chemiluminescence microparticle immunoassay, and the PGI/PGII ratio was calculated. In addition, the serum hsCRP level was determined by the Abbott C16000 automatic biochemical analyzer. Results The PGI and hsCRP levels were significantly higher in men than in women, and the PGII level was slightly higher in men than in women (both P <.05). The PGI, PGII, and hsCRP levels were positively correlated with age (r = 0.210, 0.287, and 0.133, respectively; P <.05), whereas the PGI/PGII ratio was negatively correlated with age (r = –0.190; P <.05). The positive H. pylori infection rate was 30.2% among the patients in this study; H. pylori infection was not related to sex (P >.05), and the difference in age stratification was not statistically significant (P >.05). The abnormal PGI/PGII ratio in the medical examination population was not correlated with sex (P >.05). In the H. pylori positive infection group, the proportion of PGI/PGII ratio <3, the PGI and PGII levels were significantly higher than those in the H. pylori negative infection group, and the PGI/PGII ratio was significantly lower than that in the negative group (both P <.05). The hsCRP level was not associated with H. pylori infection (P >.05), and it was significantly higher in the PGI/PGII ratio <3 group than in the PGI/PGII ratio ≥3 group (P <.05). Conclusion The PGI and PGII levels and the PGI/PGII ratio are correlated with H. pylori infection. The abnormal PGI/PGII ratio is closely related to H. pylori infection and hsCRP level. Therefore, H. pylori infection status and hsCRP level should be considered when determining atrophic gastritis by the PGI/PGII ratio.
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Potiazhenko, М. М., О. P. Mintser, and G. V. Nevoit. "Instrumental Impedance Measurement as a Component of an Objective Structured Clinical Examination to Determine Body Composition in Patients with Non-Communicable Diseases." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 6, no. 5 (October 27, 2021): 226–32. http://dx.doi.org/10.26693/jmbs06.05.226.
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The purpose of the study is to assess the clinical feasibility and indicators of instrumental impedance measurement in patients who are at various stages of the cardiovascular continuum, in order to increase the effectiveness of measures for the prevention and treatment of non-communicable diseases in Ukraine by improving the diagnosis and prevention of non-communicable diseases through the introduction of modern science-intensive technologies into medical practice. Materials and methods. An open, non-randomized controlled study was performed with the assessment of examination on a BF 500 body composition monitor (model HBF-500-E, Omron Healthcare, Japan) in 186 functionally healthy individuals (control; in 75 respondents of professional athletes (group K1), in 111 respondents – intern doctors (group K2)) and in 253 patients with non-communicable diseases (main group). The patients were divided into four subgroups (Pg1, Pg2, Pg3, Pg4) depending on the stage of the cardiovascular continuum. Results and discussion. Non-compliance with the norm of body composition was found in 83% of respondents in group K2 and in 100% of patients. 83% of people were deficient in muscle, 23% had preobesity, 6% were obese, and 5% had visceral obesity. Overweight by body mass index was in 30% of Pg1 patients, in 31% of Pg2 patients, in 30% of Pg3 patients, in 37% of Pg4 patients and obesity was in 32% of Pg1 patients, in 31% of Pg2 patients, in 25% of Pg3 patients, in 35% of Pg4 patients. Overweight in the percentage of fat was diagnosed in 17% of Pg1 patients, in 31% of Pg2 patients, in 21% of Pg3 patients, in 37% of Pg4 patients; obesity was in 37% of Pg1 patients, in 48% of Pg2 patients, in 56% of Pg3 patients, in 51% of Pg4 patients. Visceral obesity was diagnosed in 35% of Pg1 patients, in 56% of Pg2 patients, in 60% of Pg3 patients, in 77% of Pg4 patients. Deficiency of muscle percentage was found in 85% of Pg1 patients, in 91% of Pg2 patients, in 89% of Pg3 patients, and in 88% of Pg4 patients. Conclusion. Instrumental impedance measurement shows clinical significance and should become a mandatory method of Objective Structured Clinical Examination. The body composition of patients with non-communicable diseases is characterized by an increase in energy expenditure of the main metabolism, general and visceral obesity, muscle deficiency. The degree and number of cases of violation of body composition increases with the progression of the cardiovascular continuum
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Matsuoka, Toshiyuki, and Shuh Narumiya. "Prostaglandin Receptor Signaling in Disease." Scientific World JOURNAL 7 (2007): 1329–47. http://dx.doi.org/10.1100/tsw.2007.182.
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Prostanoids, consisting of the prostaglandins (PGs) and the thromboxanes (TXs), are a group of lipid mediators formed in response to various stimuli. They include PGD2, PGE2, PGF2α, PGI2, and TXA2. They are released outside of the cells immediately after synthesis, and exert their actions by binding to a G-protein coupled rhodopsin-type receptor on the surface of target cells. There are eight types of the prostanoid receptors conserved in mammals from mouse to human. They are the PGD receptor (DP), four subtypes of the PGE receptor (EP1, EP2, EP3, and EP4), the PGF receptor (FP), PGI receptor (IP), and TXA receptor (TP). Recently, mice deficient in each of these prostanoid receptors were generated and subjected to various experimental models of disease. These studies have revealed the roles of PG receptor signaling in various pathological conditions, and suggest that selective manipulation of the prostanoid receptors may be beneficial in treatment of the pathological conditions. Here we review these recent findings of roles of prostanoid receptor signaling and their therapeutic implications.
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Wennmalm, Å., G. Benthin, E. F. Granström, L. Persson, and S. Winell. "2,3-Dinor metabolites of thromboxane A2 and prostacyclin in urine from healthy human subjects: diurnal variation and relation to 24 h excretion." Clinical Science 83, no. 4 (October 1, 1992): 461–65. http://dx.doi.org/10.1042/cs0830461.
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1. Urinary levels of the 2,3-dinor metabolites of thromboxane A2 (2,3-dinor-thromboxane A2, Tx-M) and prostacyclin (2,3-dinor-6-keto-prostaglandin F1α, PGI-M) are frequently analysed as indices of platelet and endothelial activity and interaction in vivo. Despite this, little is known about the possible diurnal variations in urinary Tx-M and PGI-M in healthy human subjects, and how the urinary levels of Tx-M and PGI-M in single samples reflect their respective 24 h excretion rates. We addressed this by determining Tx-M, PGI-M and creatinine in consecutive portions of urine collected during 24 h in 15 healthy non-smoking subjects. 2. The total 24 h excretion of Tx-M and PGI-M did not differ between men (223 ± 31 and 132 ± 27 ng, respectively) and women (215 ± 44 and 127 ± 29 ng, respectively). Neither the excretion of Tx-M nor that of PGI-M displayed any significant diurnal variation. 3. The excretion of Tx-M during a 3 h period and the Tx-M/creatinine ratio in a urine sample accurately reflected the 24 h excretion of Tx-M (correlation coefficient ranges 0.74–0.94 and 0.74–0.86, respectively). The excretion of PGI-M during a 3 h period and the PGI-M/creatinine ratio in a urinary sample were accurate measures of 24 h excretion of PGI-M (correlation coefficient ranges 0.76–0.94 and 0.72–0.83, respectively). Urinary Tx-M and PGI-M expressed as simple concentrations were poor indices of their respective 24 h excretion. 4. We conclude that time-related excretions of Tx-M and PGI-M may be the best indices ex vivo of the cardiovascular formation of thromboxane A2 and prostacyclin, but that urinary creatinine-related concentrations of Tx-M and PGI-M in a urine sample are accurate measures as well.
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Hashemi, A., A. Estilai, and B. Ehdaie. "Inheritance of Aconitase, Shikimate Dehydrogenase, and Phosphoglucose Isomerase in Guayule." Journal of the American Society for Horticultural Science 116, no. 4 (July 1991): 737–39. http://dx.doi.org/10.21273/jashs.116.4.737.
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Starch gel electrophoresis was carried out to investigate inheritance of aconitase (ACO), shikimate dehydrogenase (SKDH), and phosphoglucose isomerase (PGI) in guayule (Parthenium argentatum Gray). Self-incompatibility of diploid guayule (2n = 36), prevented production of F2 generations. A series of crosses was made for segregation analysis. The enzyme ACO showed two zones of activity—one monomorphic and the other polymorphic, representing one locus with two alleles. SKDH was found to be coded by two loci with three alleles at each locus. Four zones of activity were found for PGI. PGI-1, the fastest zone, was poorly resolved and appeared variable. Segregation data indicated that PGI-2 is monogenic and controlled by five codominant alleles. Poor resolution of PGI-4 made it impossible to determine whether PGI-3 was the product of a separate locus or resulted from intergenic cross dimerization between PGI-2 and PGI-4. The dimeric characteristic of PGI-2 and the monomeric structure of SKDH and ACO-1 in guayule agreed with the protein structures previously reported for these enzymes in other plant species. The isozyme variation of this investigation maybe used in a breeding program to identify sexual and maternal type progenies of facultative apomictic guayule plants at the early seedling stage.
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Terauchi, Ryohei, Tom Terachi, and Naohiko T. Miyashita. "DNA Polymorphism at the Pgi Locus of a Wild Yam, Dioscorea tokoro." Genetics 147, no. 4 (December 1, 1997): 1899–914. http://dx.doi.org/10.1093/genetics/147.4.1899.
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Abstract To study the origin and maintenance mechanisms of the PGI allozyme polymorphism of a wild plant, Dioscorea tokoro, DNA sequences of the entire coding region (1701 bp) and two intronic regions (total 2049 bp) of the Pgi gene as well as a part of the Adh gene (590 bp) were analyzed. Two replacement substitutions were revealed to be responsible for the differentiation of three allozymes alleles (Pgi-a, Pgi-b and Pgi-c) that occur in natural population in intermediate frequencies. Interspecific comparison of DNA sequences identified Pgi-6 as the oldest allele, from which two other alleles were derived probably within the last 150,000 years. The level of DNA polymorphism at D. tokoro Pgi locus was low. No elevated level of DNA polymorphism was detected in the close vicinity of the two replacement sites differentiating the three allozymes. Departures from the neutral mutation hypothesis were detected by Fu and Li's and MK tests. The observed patterns of DNA polymorphism are explainable by both (1) the neutral mutation hypothesis with an assumption of small effective size of D. tokoro population, and (2) the positive selection hypothesis that the allele frequencies of Pgi-a and Pgi-c have increased in a short time by their selective advantages.
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Degani, Chemda, Menashe Cohen, Ruth El-Batsri, and Shmuel Gazit. "PGI Isozyme Diversity and Its Genetic Control in Mango." HortScience 27, no. 3 (March 1992): 252–54. http://dx.doi.org/10.21273/hortsci.27.3.252.
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Leaf phosphoglucose isomerase (PGI) isozymes from 139 cultivars and seedlings of mango (Mangifera indica L.) were analyzed by starch gel electrophoresis. Six distinct banding patterns of PGI-2 consisting of single- and triple-banded phenotypes were detected. The genetic control of PGI-2 isozymes were inferred from segregating progenies of self-pollinated parent cultivars having triple-banded phenotypes. Comparison of the banding patterns of PGI-2 isozymes extracted from the pollen and the leaf of the same heterozygous cultivar demonstrates the allelism of the Pgi-2 locus.
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Jones, T. W. A., E. Pichersky, and L. D. Gottlieb. "ENZYME ACTIVITY IN EMS-INDUCED NULL MUTATIONS OF DUPLICATED GENES ENCODING PHOSPHOGLUCOSE ISOMERASES IN CLARKIA." Genetics 113, no. 1 (May 1, 1986): 101–14. http://dx.doi.org/10.1093/genetics/113.1.101.
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ABSTRACT The duplication of the nuclear gene encoding the cytosolic isozyme of phosphoglucose isomerase (PGI; EC 5.3.1.9) originated within Clarkia, a genus of annual plants native to California. Previous immunological studies showed that species with and without the duplication have the same levels of cytosolic PGI activity (relative to that of the plastid PGI isozyme), as well as similar levels of cytosolic PGI protein. In the present study, we characterized seven EMS-induced null activity mutations in both duplicate PGI genes. The mutations reduced PGI activity levels in direct proportion to the normal contribution of each gene. Homozygous mutants at Pgi-3 had 64% of wild-type activity, whereas those at Pgi-2 had only 36%. The effects of the mutations at the two loci were additive, as shown by further reductions in activity in certain progeny classes in F2 progenies between them. The homozygous double null mutant class was not recovered and is presumably lethal. All of the mutants appear to be CRM+. The results account for the previously observed differences in in vivo accumulation of the duplicate isozymes in numerous Clarkia species. The results further show that PGI activity is not directly regulated by metabolic factors and suggest that the reduced PGI levels in Clarkias with the duplication probably evolved by regulatory changes in transcription or translation. The study also demonstrates a novel method to evaluate whether a particular enzyme activity is essential.
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Di Cerbo, Alessandro, Dino Miraglia, Leonardo Marino, Roberta Stocchi, Anna Rita Loschi, Stefano Fisichella, Natalina Cammertoni, et al. "“Burrata di Andria” PGI Cheese: Physicochemical and Microbiological Features." Foods 9, no. 11 (November 19, 2020): 1694. http://dx.doi.org/10.3390/foods9111694.
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In the last century, the exponential increase of industrial food production led to the disappearance of “Italian traditional niche products”. However, national regulations allowed the preservation of several of these products, including the burrata cheese. Twenty-one samples from three different batches of “Burrata di Andria” Protected Geographical Indication (PGI) were purchased from dairy factories of the PGI consortium. Moisture value of PGI Burrata cheese was significantly higher than that before the PGI release. Moreover, a significantly lower NaCl value was detected in PGI raw milk Burrata cheeses with respect to non-PGI ones, while an opposite situation was detected in pasteurized milk Burrata cheeses. As for pH, in all PGI products lower values were observed with respect to non-PGI products, which resulted significant only in pasteurized ones. No Salmonella spp., Listeria monocytogenes, and Bacillus cereus were detected, while nine samples were positive for a nonpathogenic strain of Yersinia enterocolitica. Total viable count (TVC) and Escherichia coli resulted significantly lower in pasteurized than in raw milk PGI Burrata cheese samples. Although samples analyzed can be considered microbiologically safe, these were borderline and/or unsatisfactory for E. Coli and coagulase-positive staphylococci (CPS) according to process hygiene criteria established by European regulation. Therefore, different strategies should be adopted to improve products hygiene in the considered dairy factories.
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Parker, Jackie, and Greg Simpson. "Visitor Satisfaction with a Public Green Infrastructure and Urban Nature Space in Perth, Western Australia." Land 7, no. 4 (December 17, 2018): 159. http://dx.doi.org/10.3390/land7040159.
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The widely applied Importance-Performance Analysis (IPA) provides relatively simple and straightforward techniques to assess how well the attributes of a good or service perform in meeting the expectations of consumers, clients, users, and visitors. Surprisingly, IPA has rarely been applied to inform the management of urban public green infrastructure (PGI) or urban nature (UN) spaces. This case study explores the visitor satisfaction levels of people using a PGI space that incorporates UN, close to the central business district of Perth, Western Australia. With diminishing opportunities to acquire new PGI spaces within ever more densely populated urban centers, understanding, efficiently managing, and continuously improving existing spaces is crucial to accessing the benefits and services that PGI and UN provide for humankind. An intercept survey conducted within the Lake Claremont PGI space utilized a self-report questionnaire to gather qualitative and quantitative data (n = 393). This case study demonstrates how the IPA tool can assist urban planners and land managers to collect information about the attributes of quality PGI and UN spaces to monitor levels of service, to increase overall efficiency of site management, to inform future management decisions, and to optimize the allocation of scarce resources. The satisfaction of PGI users was analyzed using the IPA tool to determine where performance and/or resourcing of PGI attributes were not congruent with the expectations of PGI users (generally in the form of over-servicing or under-servicing). The IPA demonstrated that a majority of PGI users perceived the study site to be high performing and were satisfied with many of the assessed attributes. The survey identified the potential for some improvement of the amenity and/or infrastructure installations at the site, as well as directing attention towards a more effective utilization of scarce resources. Optimizing the management of PGI spaces will enhance opportunities for individuals to obtain the physiological, psychological, and emotional benefits that arise from experiencing quality urban PGI spaces. This case study promotes the important contribution that high-quality PGI spaces, which include remnant and restored UN spaces, make to the development of resilient and sustainable urban centers.
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Hutabarat, Binsar Antoni. "EVALUASI TERHADAP RUMUSAN PERNYATAAN PASTORAL PGI TENTANG LGBT." Societas Dei: Jurnal Agama dan Masyarakat 6, no. 2 (December 6, 2019): 135. http://dx.doi.org/10.33550/sd.v6i2.124.
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“Evaluasi terhadap Rumusan Pernyataan Pastoral Majelis Pekerja Harian PGI (Persekutuan Gereja-gereja di Indonesia)” 28 Mei 2016 tentang LGBT (lesbian, gay, biseksual, transgender) fokus pada evaluasi terhadap rumusan Pernyataan Pastoral MPH PGI yang berisi himbauan terhadap gereja-gereja anggota PGI, masyarakat dan negara. Evaluasi ini didasarkan pada konteks gereja-gereja anggota PGI yang terbagi dua, yakni gereja-gereja yang menolak orientasi seksual LGBT, dan sebagian lagi yang menerima orientasi seksual LGBT. Metode penelitian yang digunakan adalah metode evaluasi rumusan kebijakan, secara khusus tentang bagaimana proses perumusan kebijakan itu dihasilkan, dan isi dari rumusan kebijakan tersebut. Temuan tulisan ini adalah Pernyataan Pastoral MPH-PGI tentang LGBT merupakan rumusan kebijakan elite MPH-PGI yang lebih berpihak kepada kelompok-kelompok yang menerima orientasi seksual LGBT, dan kurang memerhatikan pandangan mereka yang menolak orientasi seksual LGBT.
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Bowler, Shaun, Timothy Kaufman-Osborn, Valerie Martinez-Ebers, Kenneth J. Meier, and Ronald Schmidt. "How PGI came about …" Politics, Groups and Identities 1, no. 1 (March 2013): 1–3. http://dx.doi.org/10.1080/21565503.2012.758591.
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Ahrendsen, Bruce L., and Edward Majewski. "Protected geographical indication recognition and willingness to pay: A case of grojec apple." Applied Studies in Agribusiness and Commerce 11, no. 3-4 (December 31, 2017): 73–80. http://dx.doi.org/10.19041/apstract/2017/3-4/11.
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The Grojec region of Poland is an important region for apple production and accounts for 40 percent of domestic apple production. Apple growers from the region made an attempt to strengthen their competitive position through registering their apples as Protected Geographical Indication (PGI) products. The European Commission’s PGI allows food producers to obtain market recognition and a premium price for their products. Although the Grojec Apple received PGI registration in 2011, little has been done to promote apples with the PGI label. Two important research questions are addressed: 1) Does the Polish market recognize Grojec Apple PGI, and 2) Does the market value Grojec Apple PGI? Logit and regression models are estimated using survey data collected during an International MBA in Agribusiness and Commerce study week in Warsaw. Only 22% of consumers recognize Grojec Apple PGI. Yet, 70% of consumers indicate they are willing to pay more for the product and their average willingness to pay (WTP) premium is 32%. Results indicate use of the PGI label may be effective in improving sales and profit margins for Grojec Apple producers and their affiliated cooperatives. Older consumers are more likely to indicate a WTP premium. Males, smaller households, and consumers less sensitive to apple price indicate a higher WTP premium. An advertising campaign promoting Grojec Apple PGI as a better product may be effective at increasing consumer likelihood to pay more and WTP premium. Although “Grojec” is already familiar to most consumers in central Poland as a region for apples, a Grojec Apple with PGI label would assure consumers they are purchasing apples from the Grojec region and the apples are high quality.
JEL Code: D12, Q13, Q18
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Parker, Jackie, and Greg D. Simpson. "Public Green Infrastructure Contributes to City Livability: A Systematic Quantitative Review." Land 7, no. 4 (December 18, 2018): 161. http://dx.doi.org/10.3390/land7040161.
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Consistent with the Land Urbanism and Green Infrastructure theme of this special issue of Land, the primary goal of this review is to provide a plain language overview of recent literature that reports on the psychological, physiological, general well-being, and wider societal benefits that humans receive as a result of experiencing public green infrastructure (PGI) and nature in urbanized landscapes. This enhanced well-being and the wider societal benefits that accrue to urban dwellers as a result of interacting with quality PGI contributes to the concept known as city or urban livability. The quantitative analysis and theoretical synthesis reported in this review can inform decision makers, stakeholders, and other PGI and urban nature (UN) researchers of the benefits that urban populations receive from experiencing quality PGI spaces and UN and the contribution those spaces make to the livability of urban areas. With diminishing opportunities for the acquisition of new public open space to increase PGI and re-establish UN near urban centers, the efficient management and continuous improvement of existing PGI and UN is essential to promote and foster opportunities for human-to-nature contact and the known benefits therein derived. In addition to identifying an increased research interest and publication of articles that report on the contribution of PGI spaces to urban livability over the past decade, the review identifies and reports on the seven focus areas of PGI-livability research and the six attributes of PGI spaces that the current literatures report as contributing to the livability of urbanized landscapes. After providing a quantitative analysis for the reporting of those research areas and PGI attributes and summarizing key findings reported in the literature regarding the contribution that PGI spaces make to urban livability, this review also identifies knowledge gaps in the published literature and puts forward recommendations for further research in this rapidly expanding multidisciplinary field of research and policy development.
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Monfort, Jean-Claude, Anne-Marie Lezy, Annie Papin, and Sophie Tezenas du Montcel. "Psychogeriatric Inventory of Disconcerting Symptoms and Syndromes (PGI-DSS): validity and reliability of a new brief scale compared to the Neuropsychiatric Inventory for Nursing Homes (NPI-NH)." International Psychogeriatrics 32, no. 9 (April 24, 2020): 1085–95. http://dx.doi.org/10.1017/s1041610220000496.
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ABSTRACTObjectives:To validate the Psychogeriatric Inventory of Disconcerting Symptoms and Syndromes (PGI-DSS), a single scale in A4 format comprising four disconcerting syndromes (violence, refusal, words, and acts). The scale enables an immediate conversion of a qualitative assessment to a quantitative assessment. The PGI-DSS was compared with the Neuro Psychiatric Inventory for Nursing Homes (NPI-NH).Design:Cross-sectional descriptive and correlational studies.Setting:Thirty geriatric care units and nursing homes.Participants:Raters interviewed nurses and nursing assistants in charge of older adults hospitalized in geriatric care units or living in nursing homes (N = 226).Measurements:The French version of the PGI-DSS and the French version of the NPI-NH.Results:The correlation coefficient between the PGI-DSS and the NPI-NH was 0.70 (p < 0.0001). The PGI-DSS threshold score corresponding to the NPI threshold score was 17 (specificity: 87%, sensitivity: 63%). Four statistical factors, corresponding to the four clinical syndromes, explained 53.4% of the total variance. The internal consistency of the PGI-DSS (Cronbach’s alpha = 0.695) was higher than that of the NPI-NH (Cronbach’s alpha = 0.474). Test–retest reliability was better for the PGI-DSS than for the NPI-NH. The intraclass correlations were 0.80 [0.73; 0.86] and 0.75 [0.67; 0.83], respectively. Interrater reliability was better for the PGI-DSS than for the NPI-NH. The intraclass correlations were 0.65 [0.55–0.76] and 0.55 [0.43–0.68], respectively.Conclusion:The PGI-DSS was developed to overcome the limitations of the NPI-NH. New, brief, easy to administer in less than 4 minutes, foldable in four parts, pocket-sized, easy-to-read in the palm of the hand, PGI-DSS could have similar or better statistical properties than the NPI-NH. Whereas the 10 domains in the NPI-NH have clinical utility for clinicians, the four easily understandable syndromes in the PGI-DSS can help avoid inappropriate attitudes and can guide psychosocial interventions. It could likewise improve dialogue between caregivers and clinicians.
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Souza, Rogério Fernandes de, and Eucleia Primo Betioli Contel. "Análise da variabilidade de isoenzimas em acessos e cultivares de girassol." Pesquisa Agropecuária Brasileira 36, no. 5 (May 2001): 771–79. http://dx.doi.org/10.1590/s0100-204x2001000500007.
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O número de genótipos de girassol (Helianthus annuus L.) disponíveis aos agricultores é pequeno e pouco se conhece sobre os genótipos provenientes de outros países que possam ser utilizados no melhoramento genético desta cultura. O objetivo deste trabalho foi analisar a variabilidade genética de 31 acessos e de cinco cultivares nos sistemas isoenzimáticos fosfoglicomutase (PGM), 6fosfogliconato desidrogenase (PGD), fosfoglicoisomerase (PGI) e esterase (EST). Utilizou-se a técnica de eletroforese em gel de amido/penetrose para o fracionamento das isoenzimas da PGM, PGI e PGD e focalização isoelétrica para EST. Foram detectados um total de seis locos e 14 alelos para estes quatro sistemas. Observou-se variantes alélicas para os locos Pgi2, Pgm1, Pgd2, cada um com dois alelos, e para Est1, que apresentou seis alelos. Os testes de adequação aos modelos de equilíbrio de Hardy-Weinberg e de Wright evidenciaram que em dez acessos houve um desvio significativo de endocruzamento.
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MATTAR, Rejane, Sergio Barbosa MARQUES, Igor Braga RIBEIRO, Thiago Arantes de Carvalho VISCONTI, Mateus FUNARI, and Eduardo Guimarães Hourneaux DE MOURA. "DIAGNOSTIC ACCURACY OF GASTROPANEL® FOR ATROPHIC GASTRITIS IN BRAZILIAN SUBJECTS AND THE EFFECT OF PROTON PUMP INHIBITORS." Arquivos de Gastroenterologia 57, no. 2 (June 2020): 154–60. http://dx.doi.org/10.1590/s0004-2803.202000000-29.
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ABSTRACT BACKGROUND: It has been proposed that the combination of gastrin-17 (G-17), pepsinogens I and II (PGI and PGII), and anti-Helicobacter pylori (H. pylori) antibodies (GastroPanel®, BIOHIT HealthCare, Helsinki, Finland) could serve as biomarkers of atrophic gastritis. OBJECTIVE: This study aimed to ensure the diagnostic accuracy of GastroPanel® and evaluate the effect of proton pump inhibitors (PPIs) on these biomarkers. METHODS: Dyspeptic patients who underwent gastrointestinal endoscopy were enrolled in the present study. Histological findings, which were the gold standard to stratify groups, were as follows: no atrophy (controls); antrum atrophy; corpus atrophy; multifocal atrophy; and neoplasia. G-17, PGI, PGII, and anti-H. pylori immunoglobulin (Ig)G antibodies were assayed using commercially available kits. The ratio of PGI/PGII was calculated. RESULTS: Among 308 patients, 159 (51.6%) were PPI users. The overall prevalence of atrophy was 43.8% (n=135). Ninety-two (29.9%) patients were H. pylori positive according to anti-H. pylori IgG levels. G-17 levels were not low in those with antrum atrophy but were high in those with corpus and multifocal atrophies. PGI levels were significantly lower in those with corpus and multifocal atrophies. The sensitivity of PGI <30 µg/L to detect corpus atrophy was 50% (95% CI 27.8-72.1%), with a specificity of 93.2% (95% CI 84.3-97.5%), a positive likelihood ratio of 7.4 (95% CI 2.9-19.2), and a negative likelihood ratio of 0.5 (95% CI 0.3-0.8). A small number of subjects (n=6) exhibited moderate to intense atrophy (4%), among whom 66.7% exhibited decreased PGI levels. PPI significantly increased the levels of G-17 and PGI, except in those with corpus and multifocal atrophies, in whom PGI levels were not increased by PPIs. CONCLUSION: GastroPanel® (Gastrin-17, PGI, and PGI/PGII ratio) did not demonstrate high sensitivity for detecting gastric atrophy.
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Al-Ezzy, Ali Ibrahim Ali. "Immunomodulatory Effect of H. Pylori CagA Genotype and Gastric Hormones On Gastric Versus Inflammatory Cells Fas Gene Expression in Iraqi Patients with Gastroduodenal Disorders." Open Access Macedonian Journal of Medical Sciences 4, no. 3 (June 5, 2016): 364–73. http://dx.doi.org/10.3889/oamjms.2016.032.
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AIM: To evaluate the Immunomodulatory effects of CagA expression; pepsinogen I, II & gastrin-17 on PMNs and lymphocytes Fas expression in inflammatory and gastric cells; demographic distribution of Fas molecule in gastric tissue and inflammatory cells.METHODS: Gastroduodenal biopsies were taken from 80 patients for histopathology and H. pylori diagnosis. Serum samples were used for evaluation of pepsinogen I (PGI); (PGII); gastrin-17 (G-17).RESULTS: Significant difference (p < 0.001) in lymphocytes & PMNs Fas expression; epithelial & lamina propria Fas localization among H. pylori associated gastric disorders. No correlation between grade of lymphocytes & PMNs Fas expression in gastric epithelia; lamina propria and types of gastric disorder. Significant difference (p < 0.001) in total gastric Fas expression, epithelial Fas; lamina propria and gastric gland Fas expression according to CagA, PGI; PGII; PGI/PGII; Gastrin-17. Total gastric Fas expression has significant correlation with CagA, PGII levels. Gastric epithelial and gastric lamina propria Fas expression have significant correlation with CagA, PGI; PGII levels. Significant difference (p < 0.001) was found in lymphocytes & PMNs Fas expression; epithelial & lamina propria localization of lymphocytes & PMNs Fas expression according to CagA, PGI; PGII; PGI/PGII; Gastrin-17. Lymphocytes Fas expression have correlation with PGI, PGII, PGI/PGII. PMNs Fas expression have correlation with PGI, PGII.CONCLUSION: Fas gene expression and localization on gastric and inflammatory cells affected directly by H. pylori CagA and indirectly by gastric hormones. This contributes to progression of various gastric disorders according to severity of CagA induced gastric pathology and gastric hormones disturbance throughout the course of infection and disease.
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Harder, Donald E. "Usefulness of Gene Pg10 as a Source of Stem Rust Resistance in Oat Breeding." Phytopathology® 89, no. 12 (December 1999): 1214–17. http://dx.doi.org/10.1094/phyto.1999.89.12.1214.
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Infection types produced by Puccinia graminis f. sp. avenae on plants of Avena sativa with the stem rust resistance gene Pg10 are characterized by moderate-sized uredinia surrounded by an area of chlorosis and a larger variable zone of dark brown necrosis. This study was undertaken to assess the effectiveness of gene Pg10 as a source of resistance to stem rust and to determine the interactions of this gene with other common Pg genes. A derived Pg10 line was tested with 58 distinct pathotypes of P. graminis f. sp. avenae and was crossed to substituted single-gene lines carrying the resistance gene Pg1, Pg2, Pg3, Pg4, Pg8, Pg9, Pg13, Pg15, Pg16, or Pga. The Pg10 line showed moderate resistance to all 58 patho-types, and there was no indication of specificity in virulence by any isolate. Gene Pg10 was inherited independently of the other Pg genes and had a complementary effect on the expression of resistance by these genes. An effective level of resistance conferred by Pg10 was demonstrated in a field nursery artificially inoculated with P. graminis f. sp. avenae. It was concluded that Pg10 is a potentially useful source of stem rust resistance in oat breeding, with its main attributes being an apparent broad base of resistance, ease of combining with other Pg genes, and complementary effects on the expression of other Pg genes
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Fetch, T. G., and Y. Jin. "Letter Code System of Nomenclature for Puccinia graminis f. sp. avenae." Plant Disease 91, no. 6 (June 2007): 763–66. http://dx.doi.org/10.1094/pdis-91-6-0763.
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Current systems that describe the virulence phenotype in Puccinia graminis f. sp. avenae lack a systematic approach for the naming of races or to provide easily made comparisons of virulence among races. A new nomenclature system that simply and systematically characterizes virulence in P. graminis f. sp. avenae is described. The new system has the distinct advantage of providing easily seen relationships among races in contrast to previous nomenclature systems. This allows for easier interpretation of virulence relationships in the oat stem rust population and provides a large amount of virulence information with a minimum of written characters. This system uses single-gene differential lines with the resistance genes Pg1, Pg2, Pg3, Pg4, Pg6, Pg8, Pg9, Pg10, Pg12, Pg13, Pg15, and Pg16, grouped into three subsets of four lines in sequential Pg gene order. By grouping in sequential gene number order, the relationship of the new system to the “standard” system is easily seen. Each race is designated by a three-letter code, based on the seedling reaction (low or high) on 12 differential lines. The letter code nomenclature system is open ended and can be updated easily as new differential genes are identified. This system simply and precisely describes the virulence phenotypes of isolates of P. graminis f. sp. avenae, and allows for easily made comparisons of virulence of isolates collected over time and across geographical locations worldwide.
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Weigold, Ingrid K., Rebecca A. Boyle, Arne Weigold, Stephen Z. Antonucci, Heike B. Mitchell, and Caitlin A. Martin-Wagar. "Personal Growth Initiative in the Therapeutic Process: An Exploratory Study." Counseling Psychologist 46, no. 4 (May 2018): 481–504. http://dx.doi.org/10.1177/0011000018774541.
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Personal growth initiative (PGI), an individual’s active and intentional engagement in the growth process, was originally developed as a potentially useful construct in therapy. Although it has repeatedly been related to psychological well-being and distress, few studies have examined PGI in clinical samples. The current study investigated the role of PGI in a sample of 295 clients at a community-serving training clinic. Data were collected at two time points. Confirmatory factor analyses supported a second-order model with four first-order PGI factors: Readiness for Change, Planfulness, Using Resources, and Intentional Behavior. Using cross-lagged panel analysis, PGI at Time 1 was found to predict psychological distress endorsed at Time 2 after accounting for distress at Time 1.
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Hansen, Thomas, Margitta Oehlmann, and Peter Schönheit. "Novel Type of Glucose-6-Phosphate Isomerase in the Hyperthermophilic Archaeon Pyrococcus furiosus." Journal of Bacteriology 183, no. 11 (June 1, 2001): 3428–35. http://dx.doi.org/10.1128/jb.183.11.3428-3435.2001.
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ABSTRACT Glucose-6-phosphate isomerase (phosphoglucose isomerase [PGI]) (EC 5.3.1.9 ) from the hyperthermophilic archaeon Pyrococcus furiosus was purified 500-fold to homogeneity. The enzyme had an apparent molecular mass of 43 kDa and was composed of a single type of subunit of 23 kDa indicating a homodimeric (α2) structure. Kinetic constants of the enzyme were determined at the optimal pH 7 and at 80°C. Rate dependence on both substrates followed Michaelis-Menten kinetics. The apparent Km values for glucose-6-phosphate and fructose-6-phosphate were 8.7 and 1.0 mM, respectively, and the corresponding apparentV max values were 800 and 130 U/mg. The enzyme had a temperature optimum of 96°C and showed a significant thermostability up to 100°C, which is in accordance with its physiological function under hyperthermophilic conditions. Based on the N-terminal amino acid sequence of the subunit, a single open reading frame (ORF; Pf_209264) was identified in the genome of P. furiosus. The ORF was characterized by functional overexpression in Escherichia coli as a gene, pgi, encoding glucose-6-phosphate isomerase. The recombinant PGI was purified and showed molecular and kinetic properties almost identical to those of the native PGI purified from P. furiosus. The deduced amino acid sequence of P. furiosus PGI did not reveal significant similarity to the conserved PGI superfamily of eubacteria and eucarya. This is the first description of an archaeal PGI, which represents a novel type of PGI.
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Long, Christopher M., Colleen A. Mulinix, and Amy F. Iezzoni. "Production of a Microspore-derived Callus Population from Sweet Cherry." HortScience 29, no. 11 (November 1994): 1346–48. http://dx.doi.org/10.21273/hortsci.29.11.1346.
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Microspore-derived callus cultures were obtained by anther culture of `Emperor Francis' sweet cherry (Prunus avium L.). Branches were removed from the field in January and March and forced in the laboratory. When the microspores reached the uninucleate stage, anthers were placed on modified Quoirin and Lepoivre liquid culture medium containing 4.4 μm BA and 4.5 μm 2,4-D. After ≈60 days, callus that emerged from the anthers was placed on woody plant medium supplemented with 1 μm 2,4-D and 3 μm 2iP and routinely transferred. The resulting 270 callus cultures were screened for two allozymes heterozygous in `Emperor Francis', Pgi-2 and 6-Pgd-1. Of the 270 callus cultures, 154 expressed only one allele each for Pgi-2 and 6-Pgd-1; thus, they were considered microspore-derived. The microspore-derived callus cultures can be used as a linkage mapping population. Chemical names used: 6-benzyladenine (BA); 2,4-dichlorophenoxyacetic acid (2,4-D); N6-(2-isopentenyl)-adenine (2iP).
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Nehra, N. S., K. K. Kartha, and C. Stushnoff. "Isozymes as markers for identification of tissue culture and greenhouse-grown strawberry cultivars." Canadian Journal of Plant Science 71, no. 4 (October 1, 1991): 1195–201. http://dx.doi.org/10.4141/cjps91-167.
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Polyacrylamide gel electrophoresis (PAGE) was used for analysis of isozyme banding patterns of leucine aminopeptidase (LAP), phosphoglucomutase (PGM), phosphoglucoisomerase (PGI), esterase (EST) and 6-phosphogluconate dehydrogenase (6-PGD) in strawberry leaves. The extracts prepared from young leaf tissues using polytron homogenization and an extraction buffer containing 15 mg ml−1 dithiothreitol (DTT) and 10% insoluble polyvinylpyrrolidone (PVP-6755) gave best resolution for these enzymes. The influence of plant age and various growing environments on the stability of isozyme phenotypes was examined. The isozyme banding patterns of 6-PGD were found to vary with the change in growing environment as well as age of the plants. EST produced different banding patterns in greenhouse and tissue culture leaves. However, the isozyme phenotypes of LAP, PGM and PGI remained stable under all the conditions tested. Using a combination of these three stable enzymes, it was possible to distinguish eight strawberry cultivars under both tissue culture and greenhouse conditions. Key words: Fragaria × ananassa Duch., meristem culture, polyacrylamide gel electrophoresis
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Pakzad-Shahabi, Lillie, James Tallant, Mary Wells, and Matthew Williams. "CaPaBLE: Comparing the Patient Generated Index to standard quality of life measures in patients and caregivers affected by high-grade brain tumours - Preliminary analysis." Neuro-Oncology 23, Supplement_4 (October 1, 2021): iv2. http://dx.doi.org/10.1093/neuonc/noab195.003.
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Abstract Aims High grade gliomas are rare but have the highest number of cancer deaths in the under-40s. Treatment options are limited, resulting in a clinical focus on maintaining quality of life (QoL). However standard QoL assessment tools are time consuming, may not reflect an individual’s priorities, and are rarely used in clinical practice. Moreover, the impact of caring for someone with a high grade glioma is seldom assessed. An alternative approach to assessing quality of life is to use a patient - or carer-generated index (PGI/CaGI), which asks patients & carers to raise, rank and number their concerns. This may offer a route to individualised QoL assessments within clinical and research settings. The CaPaBLE study tests the feasibility and acceptability of the PGI and CaGI methodology in patients with high-grade glioma and their caregivers. This paper highlights key similarities and differences of the PGI/CaGI to standard QoL questionnaires. Method CaPABLE is an observational phase 2 non-randomised study following patients and their caregivers over 6 months starting at either first diagnosis or recurrence (https://www.isrctn.com/ISRCTN45555598). Patients and caregivers complete both standard questionnaires (EORTC QLQ C30 & BN20 and CargoQOL) and PGI/CAGI at 5 timepoints over the 6 month period. Each time the patients/caregivers complete the PGI/CAGI they are asked to identify up to 5 main topics of concern for their QoL, to score these, and rank their importance. For this analysis, we grouped topics into themes, compared the stability of themes over time and to EORTC domains. Analyses of EORTC measures are conducted using standard scoring approaches. Here we present an initial analysis of occurrence of PGI/CaGI themes compared to EORTC domains, but do not consider scores or ranking. Results 6 patients (4 male) and 5 caregivers (3 female; 4 paired with patients; one unpaired) have completed both standard questionnaire and PGI/CaGI at three or more time points, with a total of 19 (patient) and 18 (caregiver) assessments. On average people reported 3 topics at each assessment. The PGI generated 59 topics (32 themes); the CaGI, 50 topics (23 themes) and themes were consistent over time. The most common domain raised by patients was “social life” (13). Caregivers raised “personal life and family” (12 and “planning ahead” (7) more commonly. Of the 32 PGI themes, 23 align with EORTC domains. 9 PGI themes were not represented in the EORTC questionnaires, and 14 EORTC domains did not appear in the PGI. Of the 23 CaGI themes, 17 align with 7 CarGOQOL domains. 6 CaGI themes were not represented in the CarGOQOL and 3 CarGOQOL domains did not appear in the CaGI. Conclusion PGI and CaGI themes coincide with the main domains of EORTC (i.e., cognitive, social, role, physical, emotional functioning, future uncertainty). However, there were significant discrepancies: PGI (e.g., intimacy, ability to drive, and COVID related restrictions) and CaGI (e.g. personal life & family) highlighted themes that are not in the standard questionnaires. Both PGI/CaGI and standard questionnaires agree that symptom-related issues such as pain and seizures are not the main priority when it comes to QoL. In addition, CarGOQOL reports positive aspects of care, whereas CaGI only raised negative areas. This study is the first to show the feasibility of PGI/CaGI in a brain tumour patient & caregiver population. PGI/CaGI are notably quicker to complete and provide insights not captured by standard questionnaires. We are continuing to recruit patients and caregivers, and have submitted a protocol amendment to carry out qualitative interviews with patients and caregivers, to explore their views further.
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Humphreys, M. W., and S. J. Dalton. "Stability at the phosphoglucoisomerase (PGI/2) locus in Festuca arundinacea plants regenerated from cell suspension and protoplast culture." Genome 34, no. 1 (February 1, 1991): 59–65. http://dx.doi.org/10.1139/g91-010.
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A study was made of the phosphoglucoisomerase (PGI/2) phenotype of plants regenerated from suspension and protoplast culture originating from a Festuca arundinacea (2n = 6x = 42) plant with distinct PGI/2 phenotype. Of the regenerated plants from suspension culture, 20 were abnormal in that they deviated from the PGI/2 phenotype of the donor plant. Among the abnormal plants two distinct isozyme variants absent in the original donor, which were probably the result of point mutations, were recorded. There was evidence of deletions of specific PGI/2 alleles. This was confirmed cytologically by the reduced chromosome number found in the relevant cell suspension derived plants. There was also evidence that an active allele had been transformed into a null allele. All the plants regenerated from protoplast culture had the same PGI/2 phenotype as the donor plant but were hyperpolyploid. The loss of activity of individual PGI/2 alleles in plants derived from protoplasts was masked by gene duplication because of their hyperpolyploid nature. A high degree of instability was identified in nonregenerating calli. It was thought that abnormalities in the nonregenerating calli were affecting their potential to regenerate plants.Key words: Festuca arundinacea, somaclonal variation, phosphoglucoisomerase (PGI/2), chromosome instability, point mutations.
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Kuspinar, Ayse, Kedar K. V. Mate, Anne-Louise Lafontaine, and Nancy Mayo. "Validation of an Individualized Measure of Quality of Life, Patient Generated Index, for Use with People with Parkinson’s Disease." Neurology Research International 2020 (March 30, 2020): 1–8. http://dx.doi.org/10.1155/2020/6916135.
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Introduction. Parkinson’s disease (PD) affects all aspects of an individual’s life and is heterogeneous across people and time. The Patient Generated Index (PGI) is an individualized measure of quality of life (QOL) that allows patients to identify the areas of life that are important to them. Although the PGI has immense potential for use in clinical and research settings, its validity has not been assessed in PD. The purpose of this study is to estimate how well areas of QOL that patients with PD nominate on the PGI agree with ratings obtained from standard outcome measures. Methods. Patients with PD completed the PGI and various standard patient-reported outcome (PRO) measures. The PGI and standard PRO measures were compared at the total score, domain, and item levels. Pearson’s correlations and independent t-tests were used, as well as positive and negative predictive values. Results. The sample (n = 76) had a mean age of 69 (standard deviation 9) and were predominantly men (59%). The PGI was moderately correlated (r = −0.35) with the standardized disease-specific QOL measure Parkinson’s Disease Questionnaire (PDQ-8). Within one severity rating, agreement between the PGI and different standard outcome measures ranged from 85 to 100% for walking, 69 to 100% for fatigue, 38 to 75% for depression, and 20 to 80% for memory/concentration. Conclusion. This study demonstrates that nominated areas of QOL on the PGI provide comparable results to standard PRO measures, and provides evidence in support of the validity of this individualized measure in PD.
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Huang, Jaou-Chen, Farinaz Arbab, Katherine J. Tumbusch, Jennifer S. Goldsby, Nena Matijevic-Aleksic, and Kenneth K. Wu. "Human Fallopian Tubes Express Prostacyclin (PGI) Synthase and Cyclooxygenases and Synthesize Abundant PGI." Journal of Clinical Endocrinology & Metabolism 87, no. 9 (September 2002): 4361–68. http://dx.doi.org/10.1210/jc.2002-020199.
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Simpson, Greg, and Jackie Parker. "Data for an Importance-Performance Analysis (IPA) of a Public Green Infrastructure and Urban Nature Space in Perth, Western Australia." Data 3, no. 4 (December 17, 2018): 69. http://dx.doi.org/10.3390/data3040069.
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This Data Descriptor shares the dataset generated by a visitor satisfaction survey of users of a mixed-use public green infrastructure (PGI) space in Perth, Western Australia, that incorporates remnant and reintroduced urban nature (UN). Conducted in the Austral summer of 2016–2017, the survey (n = 393) utilized the technique of Importance-Performance Analysis (IPA) to elucidate perceptions of PGI users regarding performance of the amenity and facilities at the study site. There is a growing body of research that reports the innate, inbuilt affinity of humans to natural systems and living things. As humankind has grown exponentially over the past 50 years, humanity, as a species, is living an increasingly urbanized lifestyle, resulting in spreading urban footprints and increased population densities that are causing humans to become increasingly disconnected from nature. These conflicting phenomena are driving research to understand the contribution that PGI and UN can make to enhancing the quality of life of urban residents. With diminishing opportunities to acquire or create new PGI spaces within ever-more-densely populated urban centers, understanding, efficiently managing, and continuously improving existing PGI spaces is crucial to access the benefits and services that PGI and UN provide. The IPA technique can provide the data necessary to inform an evidenced-based approach to managing and resourcing PGI and UN spaces.
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Bartáková, Vendula, Beáta Barátová, Lukáš Pácal, Veronika Ťápalová, Silvie Šebestová, Petr Janků, and Kateřina Kaňková. "Development of a New Risk Score for Stratification of Women with Gestational Diabetes Mellitus at High Risk of Persisting Postpartum Glucose Intolerance Using Routinely Assessed Parameters." Life 11, no. 6 (May 23, 2021): 464. http://dx.doi.org/10.3390/life11060464.
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The aims of the study were (i) to find predictive factors for early postpartum conversion of gestational diabetes mellitus (GDM) into persisting glucose intolerance (PGI), (ii) to evaluate potential differences in adverse perinatal outcomes in GDM women with and without early postpartum PGI and, finally, (iii) to establish a risk score to predict postpartum PGI. A cross-sectional study comprised 244 GDM patients with known age, parity, positive family history of diabetes, pre-gestational BMI, comorbidities, smoking history, results of mid-trimester oral glucose tolerance test, HbA1c, obstetric complications, neonatal outcomes and mode of delivery. A risk score was calculated using parameters with highest odds ratios in a statistic scoring model. Significant differences between women with and without PGI postpartum were ascertained for mid-trimester fasting plasma glucose (p < 0.001), HbA1c above 42 mmol/mol (p = 0.035), prevalence of obesity (p = 0.007), hypothyroidism, family history of diabetes and smoking. We also observed higher incidence of prolonged and complicated delivery in PGI group (p = 0.04 and 0.007, respectively). In conclusion, this study identified several parameters with predictive potential for early PGI and also adverse peripartal outcomes. We established a simple risk-stratification score for PGI prediction applicable for GDM affected women prior their leaving maternity ward. Yet, given a relatively small sample size as a main limitation of this study, the proposed score should be validated in the larger cohort.
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Cronenwett, Jack L. "The use of prostaglandins PGE and PGI in peripheral arterial ischemia." Journal of Vascular Surgery 3, no. 2 (February 1986): 370–74. http://dx.doi.org/10.1067/mva.1986.avs0030370.
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Wegrowski, J., M. Moczar, and L. Robert. "Proteoglycans from pig aorta. Comparative study of their interactions with lipoproteins." Biochemical Journal 235, no. 3 (May 1, 1986): 823–31. http://dx.doi.org/10.1042/bj2350823.
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Different proteoglycans (PGs) were isolated from pig aorta for aggregation studies with hyaluronic acid and human low-density lipoproteins (LDL). Extraction of the intima-media with 4M-guanidinium chloride and digestion of the residue with collagenase solubilized 91% of aortic hexuronic acid content. From the guanidinium chloride extract two PGs were isolated by ion-exchange and gel-permeation chromatography: proteochondroitin sulphate (PGI) with a protein-core apparent Mr of 250 000 and proteodermatan-chondroitin sulphate (PGII) with a protein-core apparent Mr of 55 000. Only PGI forms high-Mr aggregates with hyaluronic acid. From the collagenase digest two other PGs were isolated: proteoheparan sulphate and proteochondroitin sulphate (PGIII and PGIV respectively). PGIV had a smaller hydrodynamic size than PGI. PGI and PGII formed insoluble complexes with human LDL in the presence of Ca2+. PGIII or PGIV did not form precipitates with the LDL. PGI and PGII, but neither PGIII nor PGIV, were bound to LDL-Sepharose. The main peaks of PGI and PGII were eluted from LDL-Sepharose with 60 mM- and 90 mM-NaCl respectively. The results indicate that aortic PGs have different interacting potentials with lipoproteins, depending on their Mr and their glycosaminoglycan composition.
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Carter, P. A., and W. B. Watt. "Adaptation at specific loci. V. Metabolically adjacent enzyme loci may have very distinct experiences of selective pressures." Genetics 119, no. 4 (August 1, 1988): 913–24. http://dx.doi.org/10.1093/genetics/119.4.913.
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Abstract The polymorphic phosphoglucomutase (PGM) and glucose-6-phosphate dehydrogenase (G6PD) loci have been studied in parallel to experimental work on the phosphoglucose isomerase (PGI) polymorphism in Colias butterflies. PGI, PGM and G6PD are also autosomal in Colias. PGM and G6PD are loosely linked (and represent the first identified autosomal linkage group in Colias); they assort independently from PGI. Recombination occurs in both sexes. Neither PGM nor G6PD shows large, consistent differences in flight capacity through the day among its genotypes, as PGI does. PGM shows some change of allele frequencies, and match to Hardy-Weinberg expectation, with air temperature in middle and latter parts of the season, but not early in the season. G6PD may show some heterozygote excess over Hardy-Weinberg expectation early in the day, but more testing is needed. No evidence for differential survivorship was seen at PGM or G6PD, in contrast to PGI. At the PGM and G6PD loci, male heterozygotes are advantaged in mating with females, but without the evidence of female choice which occurs for PGI. These effects are not correlated among the three loci. There is no assortative mating at G6PD (nor at PGI). There is minor positive assortative mating of PGM heterozygotes, but it is too weak to account for the PGM-genotype-specific male mating advantage. No trends of multilocus genotype frequencies involving PGI are seen. Certain PGM-G6PD two-locus genotypes are over-represented, and others under-represented, in wild adult samples, particularly among males and uniformly among successfully mating males. Our results emphasize that enzyme loci sharing a substrate need not have common experience of the existence or strength of natural selection, and suggest initial food-resource processing and allocation as a possible context for fitness-related effects of the PGM and G6PD polymorphisms.
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Haldipur, Ashrita C., and N. Srividya. "In Vitro Glycemic Response of Indigenous Pigmented Rice Cultivars from South India and Influence of Different Carbohydrate Components." Current Research in Nutrition and Food Science Journal 8, no. 3 (December 28, 2020): 815–28. http://dx.doi.org/10.12944/crnfsj.8.3.13.
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Staple diet patterns such as white rice consumption play an important part in the occurrence of chronic lifestyle-related disease like diabetes. This study intended to identify pigmented rice cultivars from India as an alternative to white rice. Nine carbohydrate components were quantified in six red and two black pigmented rice varieties. In vitro starch digestibility was also analyzed and the predicted glycemic index (pGI) was estimated. The relationship between the carbohydrate components and the pGI of the rice varieties was analyzed. The rice varieties, Kattuyanam and Chennangi exhibited high levels of insoluble dietary fibre, total dietary fibre and amylose. High soluble dietary fibre contents were observed in Poonghar and Aruvadam kuruvai. The levels of resistant starch and slowly digestible starch were found to be the highest in Karupakavuni. The results indicated Kattuyanam, Chennangi, Karungkuruvai, and Poonghar to be low pGI rice varieties (< 55). The three varieties, Kesari, Karupakavuni, and Aruvadam kuruvai were categorized under the medium pGI category (56-69). Mapillai samba had a high pGI of 70 which could be due to processing (partially milled and parboiled), but had significantly lower pGI than the white rice, Sona masuri (GI – 76). The dietary fibre components, resistant starch, slowly digestible starch, and the amylose content were negatively correlated with the pGI. Among these components, the insoluble dietary fibre, total dietary fibre, and resistant starch with significantly high (p ≤0.01) correlation were found to be the major determining factors of pGI in the studied pigmented rice cultivars. The inclusion of the identified pigmented rice varieties with low to medium glycemic response in the diet could become a key role in the dietary management of diabetes, especially among the rice-eating population.
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Ginting, Karolin, Adrienne Stolfi, Jordan Wright, and Abiodun Omoloja. "Patient Portal, Patient-Generated Images, and Medical Decision-Making in a Pediatric Ambulatory Setting." Applied Clinical Informatics 11, no. 05 (October 2020): 764–68. http://dx.doi.org/10.1055/s-0040-1718754.
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Abstract Background Electronic health record (EHR) patient portals are a secure electronic method of communicating with health care providers. In addition to sending secure messages, images, and videos generated by families can be sent to providers securely. With the widespread use of smart phones, there has been an increase in patient-generated images (PGI) sent to providers via patient portals. There are few studies that have evaluated the role of PGI in medical decision-making. Objectives The study aimed to characterize PGI sent to providers via a patient portal, determine how often PGI-affected medical decision-making, and determine the rate of social PGI sent via patient portal. Methods A retrospective chart review of PGI uploaded to a children's hospital's ambulatory patient portal from January 2011 to December 2017 was conducted. Data collected included patient demographics, number and type of images sent, person sending images (patient or parent/guardian), and whether an image-affected medical decision-making. Images were classified as medical related (e.g., blood glucose readings and skin rashes), nonmedical or administrative related (e.g., medical clearance or insurance forms), and social (e.g., self-portraits and camp pictures). Results One hundred forty-three individuals used the portal a total of 358 times, sending 507 images over the study period. Mean (standard deviation) patient age was 9.5 (5.9) years, 50% were females, 89% were White, and 64% had private insurance. About 9% of images were sent directly by patients and the rest by parents/guardians. A total of 387 (76%) images were sent for medical related reasons, 20% for nonmedical, and 4% were deemed social images. Of the 387 medical related images, 314 (81%) affected medical decision-making. Conclusion PGI-affected medical decision-making in most cases. Additional studies are needed to characterize use of PGI in the pediatric population.
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Mohebbi, M., S. Dodd, O. M. Dean, and M. Berk. "Patient centric measures for a patient centric era: Agreement and convergent between ratings on The Patient Global Impression of Improvement (PGI-I) scale and the Clinical Global Impressions – Improvement (CGI-S) scale in bipolar and major depressive disorder." European Psychiatry 53 (May 30, 2018): 17–22. http://dx.doi.org/10.1016/j.eurpsy.2018.05.006.
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AbstractBackground:Concordant with an increased emphasis on consumer engagement, the Patient Global Impression Scale of Improvement (PGI-I) is commonly used as an outcome measure in studies evaluating the efficacy of treatments in medical and psychiatric conditions with subjective symptom domains. The current study evaluated the agreement between PGI-I and Clinician Global Impression Scale of Improvement (CGI-I) ratings and convergent validity of PGI-I among individuals with bipolar or major depressive disorders.Method:Data were derived from three double-blind, placebo-controlled, multicentre studies conducted from 2007 to 2015 among adult individuals (N = 472). Clinicians were asked to rate participants symptoms using the CGI-I as well as severity of depression by the Montgomery-Åsberg Depression (MADRS), quality of life (Q-LES-Q), social and occupational functioning (SOFAS), and functional impairment (LIFE–RIFT). Participants were asked to assess their symptom improvement with the PGI-I. Bland-Altman agreement plots and Intra-class correlations were used to evaluate agreement, and Spearman correlation coefficients were implemented to examine convergent validity. Sub-group analyses for disorder type (bipolar and major depression) were performed.Results:There was high agreement between the PGI-I and CGI-I ratings across follow-up time points (weeks 2, 4, 6, 8, 12, 16, 20, 24, and 28). Similar results were observed in male only and female only data and after adjustment for age and gender. Both PGI-I and CGI-I ratings were robustly positively correlated with MADRS, and LIFE-RIFT and negatively correlated with SOFAS and Q-LES-Q, supporting the convergent validity of the PGI-I. Sub-group analyses for bipolar and major depressive disorder showed similar findings.Conclusion:Our findings support the utility of the PGI-I as a participant rated measure of global improvement among individuals with bipolar or major depressive disorders.
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Tsuge, Seiji, Hirokazu Ochiai, Yasuhiro Inoue, Takashi Oku, Kazunori Tsuno, Hisatoshi Kaku, and Yasuyuki Kubo. "Involvement of Phosphoglucose Isomerase in Pathogenicity of Xanthomonas oryzae pv. oryzae." Phytopathology® 94, no. 5 (May 2004): 478–83. http://dx.doi.org/10.1094/phyto.2004.94.5.478.
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Xanthomonas oryzae pv. oryzae, the causal agent of bacterial leaf blight of rice, was subjected to transposon mutagenesis to generate mutants defective in pathogenicity. A novel mutant 74M913 was attenuated in virulence but retained its ability to cause the hypersensitive response in leaf blight-resistant rice and tomato. Cloning and sequence analysis revealed that the transposon in 74M913 was inserted in a gene homologous to the phosphoglucose isomerase (pgi) gene of X. axonopodis pv. citri. Growth of the mutant in a synthetic medium containing fructose or xylose as a sole carbohydrate source was much reduced, indicating the transposon disrupted pgi function. The interaction between expression of pgi and hypersensitive response and pathogenicity (hrp) genes was investigated because we had demonstrated previously that expression of hrp genes of X. oryzae pv. oryzae is induced in a synthetic medium containing xylose. However, pgi and the hrp gene (hrcU) were expressed independently. This study suggests that PGI is involved in pathogenicity of X. oryzae pv. oryzae.